miRTarBase - #MIRT529764


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pre-miRNA Information
pre-miRNA hsa-mir-4639   
Genomic Coordinates chr6: 16141556 - 16141624
Description Homo sapiens miR-4639 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4639-5p
Sequence 1| UUGCUAAGUAGGCUGAGAUUGA |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs754752699 4 dbSNP
rs765082627 5 dbSNP
rs931710265 19 dbSNP
rs1487272042 21 dbSNP
Putative Targets

Gene Information
Gene Symbol SF3B1   
Synonyms Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155
Description splicing factor 3b subunit 1
Transcript NM_012433   
Other Transcripts NM_001005526   
Expression
Putative miRNA Targets on SF3B1
3'UTR of SF3B1
(miRNA target sites are highlighted)		 
>SF3B1|NM_012433|3'UTR
   1 TTTTATTGTTTATTTTGTGTTTAATGCACAGCTACTTCACACCTTAAACTTGCTTTGATTTGGTGATGTAAACTTTTAAA
  81 CATTGCAGATCAGTGTAGAACTGGTCATAGAGGAAGAGCTAGAAATCCAGTAGCATGATTTTTAAATAACCTGTCTTTGT
 161 TTTTGATGTTAAACAGTAAATGCCAGTAGTGACCAAGAACACAGTGATTATATACACTATACTGGAGGGATTTCATTTTT
 241 AATTCATCTTTATGAAGATTTAGAACTCATTCCTTGTGTTTAAAGGGAATGTTTAATTGAGAAATAAACATTTGTGTACA
 321 AAATGCTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUUA-GAGUCGGAUGAAUCGUu 5'
            ||| | ||| ||||||  || 
Target 5' ttAATGCACAG-CTACTTCACAc 3'
 21 - 42 107.00 -7.80
2 
miRNA  3' agUUAGAGUCGGA-------UGAAUCGUu 5'
            ||| ||| |:|       |:|||| | 
Target 5' ttAAT-TCATCTTTATGAAGATTTAGAAc 3'
 239 - 266 107.00 -6.22
3 
miRNA  3' aguuagagucggaugaAUCGUu 5'
                          ||||| 
Target 5' agagctagaaatccagTAGCAt 3'
 115 - 136 100.00 -6.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26994435 30 COSMIC
COSN31604678 137 COSMIC
COSN31602406 197 COSMIC
COSN7156284 450 COSMIC
COSN8276916 878 COSMIC
COSN17416279 1293 COSMIC
COSN15050164 2116 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs753700189 6 dbSNP
rs768418002 12 dbSNP
rs1411463365 16 dbSNP
rs779526970 17 dbSNP
rs72912888 19 dbSNP
rs749888349 24 dbSNP
rs534224854 27 dbSNP
rs763541081 32 dbSNP
rs920822590 33 dbSNP
rs753184314 34 dbSNP
rs1382960920 35 dbSNP
rs765805351 38 dbSNP
rs759769456 40 dbSNP
rs930707656 42 dbSNP
rs1226254836 46 dbSNP
rs920614552 49 dbSNP
rs1257834631 53 dbSNP
rs1036336820 76 dbSNP
rs552439698 81 dbSNP
rs528008202 82 dbSNP
rs1062887 87 dbSNP
rs538479854 93 dbSNP
rs932149799 95 dbSNP
rs1164429015 96 dbSNP
rs1468160614 97 dbSNP
rs922083653 98 dbSNP
rs1044885 100 dbSNP
rs190624281 108 dbSNP
rs1178885935 110 dbSNP
rs1044886 111 dbSNP
rs1044887 115 dbSNP
rs1458849479 116 dbSNP
rs1044888 119 dbSNP
rs1358419729 123 dbSNP
rs549938968 129 dbSNP
rs1464350046 141 dbSNP
rs957753485 150 dbSNP
rs1062888 151 dbSNP
rs1250871129 154 dbSNP
rs1453496299 155 dbSNP
rs781726029 159 dbSNP
rs1296920994 162 dbSNP
rs1802306 173 dbSNP
rs1216779505 180 dbSNP
rs1296907290 182 dbSNP
rs1044889 183 dbSNP
rs112135933 196 dbSNP
rs977748547 201 dbSNP
rs1291946748 202 dbSNP
rs1461451598 206 dbSNP
rs1207560975 210 dbSNP
rs1222109367 212 dbSNP
rs1044893 213 dbSNP
rs1245603031 216 dbSNP
rs1350074474 225 dbSNP
rs970362358 228 dbSNP
rs1044894 232 dbSNP
rs1450777547 234 dbSNP
rs1187103071 235 dbSNP
rs1025347894 239 dbSNP
rs1044895 241 dbSNP
rs1431274651 243 dbSNP
rs977421974 245 dbSNP
rs1408608297 256 dbSNP
rs1179580362 258 dbSNP
rs1044896 266 dbSNP
rs1470389638 272 dbSNP
rs1319990703 273 dbSNP
rs746248674 277 dbSNP
rs762105440 279 dbSNP
rs966618404 296 dbSNP
rs113364529 297 dbSNP
rs1367491193 299 dbSNP
rs1012133734 314 dbSNP
rs1217855986 325 dbSNP
rs547748315 340 dbSNP
rs1323825565 341 dbSNP
rs1227463118 346 dbSNP
rs1044899 349 dbSNP
rs1010705134 352 dbSNP
rs527579689 353 dbSNP
rs1026798473 355 dbSNP
rs73988457 365 dbSNP
rs141294079 366 dbSNP
rs1036430021 377 dbSNP
rs1192713921 382 dbSNP
rs1429665284 384 dbSNP
rs940712540 387 dbSNP
rs560454652 412 dbSNP
rs1472136303 415 dbSNP
rs751641996 429 dbSNP
rs906251902 434 dbSNP
rs1398399031 437 dbSNP
rs1409993338 441 dbSNP
rs1402574769 448 dbSNP
rs763673183 461 dbSNP
rs932228732 465 dbSNP
rs1349841860 466 dbSNP
rs1434864439 473 dbSNP
rs1305475918 482 dbSNP
rs1379125075 482 dbSNP
rs531567494 491 dbSNP
rs922106764 496 dbSNP
rs1286120158 510 dbSNP
rs1352327965 510 dbSNP
rs1441150519 511 dbSNP
rs989691705 517 dbSNP
rs764221186 522 dbSNP
rs1319872094 528 dbSNP
rs943599422 533 dbSNP
rs562802110 535 dbSNP
rs761668296 536 dbSNP
rs182727498 541 dbSNP
rs1249917544 544 dbSNP
rs1471258546 547 dbSNP
rs1413238112 548 dbSNP
rs1487946935 552 dbSNP
rs977800929 554 dbSNP
rs1403671360 555 dbSNP
rs190933450 558 dbSNP
rs1286823877 559 dbSNP
rs1366707061 563 dbSNP
rs752284909 571 dbSNP
rs924696858 572 dbSNP
rs977829140 580 dbSNP
rs970377167 584 dbSNP
rs1247498730 589 dbSNP
rs529664707 599 dbSNP
rs1220134281 608 dbSNP
rs1024607198 613 dbSNP
rs767201068 614 dbSNP
rs1341313178 615 dbSNP
rs759191238 616 dbSNP
rs1202800222 618 dbSNP
rs991164818 619 dbSNP
rs553765489 621 dbSNP
rs959292301 622 dbSNP
rs1027304966 624 dbSNP
rs774215531 625 dbSNP
rs1287537422 626 dbSNP
rs1442907737 628 dbSNP
rs995362671 629 dbSNP
rs1386442374 633 dbSNP
rs146620696 638 dbSNP
rs1167110173 640 dbSNP
rs1399160335 642 dbSNP
rs562553927 651 dbSNP
rs1033941197 663 dbSNP
rs1357053951 679 dbSNP
rs1004930757 684 dbSNP
rs578171057 688 dbSNP
rs762850507 691 dbSNP
rs1373200379 692 dbSNP
rs970884783 693 dbSNP
rs371496838 695 dbSNP
rs1339876751 701 dbSNP
rs1199641767 714 dbSNP
rs1278210537 723 dbSNP
rs931960551 734 dbSNP
rs1205647113 738 dbSNP
rs1243760307 741 dbSNP
rs900774886 746 dbSNP
rs1053960568 748 dbSNP
rs936874129 762 dbSNP
rs538044652 764 dbSNP
rs1475975681 772 dbSNP
rs569441195 778 dbSNP
rs1422661758 783 dbSNP
rs773184686 788 dbSNP
rs768711871 794 dbSNP
rs1387358398 800 dbSNP
rs75706115 803 dbSNP
rs544019396 805 dbSNP
rs1320263658 807 dbSNP
rs1326901075 807 dbSNP
rs760877794 810 dbSNP
rs1255573605 812 dbSNP
rs1321682155 813 dbSNP
rs1225640670 815 dbSNP
rs1211059066 816 dbSNP
rs1263988797 820 dbSNP
rs1314205068 828 dbSNP
rs1203447766 829 dbSNP
rs919894950 830 dbSNP
rs1214406683 833 dbSNP
rs775511293 848 dbSNP
rs933466150 850 dbSNP
rs1481620278 853 dbSNP
rs1176760207 862 dbSNP
rs1401248781 865 dbSNP
rs961200940 878 dbSNP
rs1451022526 882 dbSNP
rs536372526 884 dbSNP
rs1041841410 892 dbSNP
rs1385581341 893 dbSNP
rs1386086968 897 dbSNP
rs1301799542 909 dbSNP
rs186228625 915 dbSNP
rs991418798 916 dbSNP
rs1004983164 925 dbSNP
rs1262500451 926 dbSNP
rs1360599036 929 dbSNP
rs181087734 931 dbSNP
rs1209829714 933 dbSNP
rs1267341578 934 dbSNP
rs1464909194 935 dbSNP
rs1424197390 943 dbSNP
rs1195778974 949 dbSNP
rs527330280 952 dbSNP
rs1200535242 955 dbSNP
rs926520035 958 dbSNP
rs533603993 959 dbSNP
rs1183366317 961 dbSNP
rs1030811059 972 dbSNP
rs1363931997 980 dbSNP
rs1456962078 988 dbSNP
rs746170570 989 dbSNP
rs779304680 990 dbSNP
rs1161641965 991 dbSNP
rs571443974 995 dbSNP
rs190695974 996 dbSNP
rs145799297 997 dbSNP
rs1182588064 1004 dbSNP
rs1389832944 1008 dbSNP
rs1309406887 1022 dbSNP
rs971831299 1026 dbSNP
rs1249842566 1027 dbSNP
rs963110528 1033 dbSNP
rs771471142 1034 dbSNP
rs749798467 1043 dbSNP
rs868474361 1053 dbSNP
rs900492481 1057 dbSNP
rs1223689841 1059 dbSNP
rs562365519 1061 dbSNP
rs768602710 1064 dbSNP
rs186708349 1070 dbSNP
rs1001034640 1080 dbSNP
rs1422782600 1083 dbSNP
rs787974 1087 dbSNP
rs1387049501 1091 dbSNP
rs1445097125 1092 dbSNP
rs1340474060 1097 dbSNP
rs998170648 1100 dbSNP
rs752261041 1120 dbSNP
rs1042507974 1129 dbSNP
rs1352606835 1130 dbSNP
rs949572503 1138 dbSNP
rs754154595 1141 dbSNP
rs780655903 1141 dbSNP
rs1452045570 1142 dbSNP
rs903393099 1146 dbSNP
rs1380801354 1151 dbSNP
rs779898212 1167 dbSNP
rs1247416999 1169 dbSNP
rs1297500839 1171 dbSNP
rs1055280682 1176 dbSNP
rs1306162371 1186 dbSNP
rs1296121429 1191 dbSNP
rs1207042950 1194 dbSNP
rs1251555970 1195 dbSNP
rs1041863685 1202 dbSNP
rs564966359 1203 dbSNP
rs540511115 1220 dbSNP
rs974003300 1221 dbSNP
rs961254865 1227 dbSNP
rs908446524 1230 dbSNP
rs1187925160 1232 dbSNP
rs1417262805 1233 dbSNP
rs937315497 1234 dbSNP
rs986653351 1235 dbSNP
rs955378440 1236 dbSNP
rs928614499 1244 dbSNP
rs1373861706 1253 dbSNP
rs1030448277 1258 dbSNP
rs982075338 1264 dbSNP
rs1334950020 1269 dbSNP
rs1408470860 1274 dbSNP
rs1453428268 1276 dbSNP
rs1288849653 1277 dbSNP
rs996629438 1281 dbSNP
rs1216725457 1285 dbSNP
rs1296658332 1287 dbSNP
rs1287521300 1291 dbSNP
rs540263544 1291 dbSNP
rs1032281851 1294 dbSNP
rs963125248 1298 dbSNP
rs1165498671 1302 dbSNP
rs1425670250 1305 dbSNP
rs1248630782 1311 dbSNP
rs1001088451 1312 dbSNP
rs1486768399 1314 dbSNP
rs902804835 1321 dbSNP
rs1266478107 1324 dbSNP
rs1178234155 1330 dbSNP
rs1458417771 1331 dbSNP
rs1174593994 1333 dbSNP
rs1431685032 1336 dbSNP
rs1470358850 1344 dbSNP
rs1158429912 1349 dbSNP
rs1240412142 1351 dbSNP
rs1433436650 1359 dbSNP
rs1015997320 1361 dbSNP
rs1212275658 1364 dbSNP
rs1403460954 1368 dbSNP
rs1042601905 1369 dbSNP
rs181334326 1370 dbSNP
rs1244828008 1371 dbSNP
rs1318180552 1377 dbSNP
rs1030390463 1406 dbSNP
rs997814985 1409 dbSNP
rs1489812007 1412 dbSNP
rs564581927 1413 dbSNP
rs1271365668 1418 dbSNP
rs1054890044 1422 dbSNP
rs937733852 1426 dbSNP
rs1176708128 1427 dbSNP
rs1011678494 1429 dbSNP
rs898175761 1432 dbSNP
rs867046794 1442 dbSNP
rs1365486297 1448 dbSNP
rs1055836149 1450 dbSNP
rs200973577 1455 dbSNP
rs1038070784 1456 dbSNP
rs1384872286 1458 dbSNP
rs1277400600 1459 dbSNP
rs1374929395 1460 dbSNP
rs1002007894 1461 dbSNP
rs544890791 1465 dbSNP
rs908495957 1467 dbSNP
rs987112495 1474 dbSNP
rs1389879450 1480 dbSNP
rs1294068413 1481 dbSNP
rs933847067 1484 dbSNP
rs1046137649 1496 dbSNP
rs1459424727 1498 dbSNP
rs1362104370 1500 dbSNP
rs1385162515 1501 dbSNP
rs1443259354 1502 dbSNP
rs1166004636 1511 dbSNP
rs921056454 1512 dbSNP
rs1409715719 1517 dbSNP
rs1326498343 1519 dbSNP
rs575718965 1526 dbSNP
rs1440541772 1527 dbSNP
rs964738535 1530 dbSNP
rs11373485 1532 dbSNP
rs397974536 1532 dbSNP
rs1451423102 1541 dbSNP
rs556008490 1542 dbSNP
rs979427538 1545 dbSNP
rs1338552004 1549 dbSNP
rs966680006 1549 dbSNP
rs1271176952 1552 dbSNP
rs536086616 1553 dbSNP
rs1021196333 1554 dbSNP
rs1036214588 1558 dbSNP
rs1014221197 1562 dbSNP
rs112320402 1571 dbSNP
rs1353900294 1574 dbSNP
rs1186005325 1575 dbSNP
rs1311003332 1578 dbSNP
rs1230730813 1584 dbSNP
rs1330278889 1592 dbSNP
rs573779759 1593 dbSNP
rs1301768034 1598 dbSNP
rs896670204 1600 dbSNP
rs1421216397 1601 dbSNP
rs1388443077 1602 dbSNP
rs554914202 1605 dbSNP
rs1002363577 1606 dbSNP
rs1403354314 1613 dbSNP
rs985899211 1615 dbSNP
rs1337367256 1616 dbSNP
rs1325736481 1617 dbSNP
rs898270995 1618 dbSNP
rs1038120978 1620 dbSNP
rs939699937 1621 dbSNP
rs1339813946 1622 dbSNP
rs1219548068 1624 dbSNP
rs922994334 1628 dbSNP
rs1321562272 1629 dbSNP
rs886738980 1630 dbSNP
rs1051022426 1634 dbSNP
rs1172030197 1635 dbSNP
rs1257520114 1636 dbSNP
rs533515240 1637 dbSNP
rs1378540400 1638 dbSNP
rs933879257 1640 dbSNP
rs1175315956 1642 dbSNP
rs1426745263 1644 dbSNP
rs571226026 1652 dbSNP
rs975683452 1656 dbSNP
rs368341219 1659 dbSNP
rs1326847649 1660 dbSNP
rs1404081302 1664 dbSNP
rs1263118066 1666 dbSNP
rs1215178001 1668 dbSNP
rs1282904887 1668 dbSNP
rs925411197 1671 dbSNP
rs1225431175 1672 dbSNP
rs1256606814 1672 dbSNP
rs1287604745 1675 dbSNP
rs200006146 1675 dbSNP
rs77550250 1676 dbSNP
rs76780166 1677 dbSNP
rs1343939554 1691 dbSNP
rs11422264 1693 dbSNP
rs1199089855 1693 dbSNP
rs1203965299 1693 dbSNP
rs1266371594 1693 dbSNP
rs1286924767 1693 dbSNP
rs1491082778 1693 dbSNP
rs570182075 1693 dbSNP
rs67299874 1693 dbSNP
rs1256359029 1694 dbSNP
rs1020466485 1696 dbSNP
rs1361034658 1697 dbSNP
rs188572734 1709 dbSNP
rs1011771707 1711 dbSNP
rs1407058339 1714 dbSNP
rs957559358 1714 dbSNP
rs1302241475 1715 dbSNP
rs1335289749 1718 dbSNP
rs1034478150 1719 dbSNP
rs766142469 1720 dbSNP
rs1355004773 1721 dbSNP
rs966691428 1726 dbSNP
rs1290111507 1727 dbSNP
rs1490940882 1735 dbSNP
rs907247478 1739 dbSNP
rs1249349858 1743 dbSNP
rs1183297797 1750 dbSNP
rs1332314125 1751 dbSNP
rs1414113835 1754 dbSNP
rs535802845 1754 dbSNP
rs992435661 1756 dbSNP
rs961275736 1758 dbSNP
rs35824333 1762 dbSNP
rs994550750 1765 dbSNP
rs897757585 1768 dbSNP
rs1294391514 1772 dbSNP
rs1033917631 1775 dbSNP
rs762797345 1780 dbSNP
rs898654852 1783 dbSNP
rs1378312756 1787 dbSNP
rs1245972362 1795 dbSNP
rs1016699404 1804 dbSNP
rs1003923462 1811 dbSNP
rs1423484392 1818 dbSNP
rs1250443938 1819 dbSNP
rs1479414927 1826 dbSNP
rs574787565 1827 dbSNP
rs1197048688 1829 dbSNP
rs886791203 1830 dbSNP
rs1050675327 1831 dbSNP
rs756736339 1835 dbSNP
rs1386990940 1840 dbSNP
rs1051174635 1842 dbSNP
rs568846379 1847 dbSNP
rs922993076 1848 dbSNP
rs548744654 1852 dbSNP
rs1039624681 1854 dbSNP
rs935872068 1868 dbSNP
rs912881995 1873 dbSNP
rs1381921772 1878 dbSNP
rs1295230177 1880 dbSNP
rs1306111746 1882 dbSNP
rs140642823 1883 dbSNP
rs957610353 1884 dbSNP
rs560203009 1885 dbSNP
rs1322279685 1892 dbSNP
rs1034487976 1897 dbSNP
rs1244933127 1901 dbSNP
rs1257239515 1904 dbSNP
rs1185731307 1910 dbSNP
rs1259472716 1913 dbSNP
rs1219127865 1915 dbSNP
rs1173152132 1923 dbSNP
rs1002070095 1930 dbSNP
rs184540860 1932 dbSNP
rs1024782115 1938 dbSNP
rs550753550 1938 dbSNP
rs1447408916 1949 dbSNP
rs530575972 1951 dbSNP
rs181464121 1965 dbSNP
rs765166177 1966 dbSNP
rs189618657 1970 dbSNP
rs563169055 1974 dbSNP
rs1016940665 1977 dbSNP
rs1006175036 1981 dbSNP
rs771761155 1983 dbSNP
rs926900271 1985 dbSNP
rs564524278 1992 dbSNP
rs775662294 1997 dbSNP
rs1258867138 2000 dbSNP
rs1050294356 2004 dbSNP
rs151330816 2006 dbSNP
rs931780745 2007 dbSNP
rs1412285036 2009 dbSNP
rs901665878 2012 dbSNP
rs142444251 2013 dbSNP
rs1160885536 2014 dbSNP
rs772083303 2017 dbSNP
rs1472197963 2019 dbSNP
rs1237648785 2021 dbSNP
rs1189161391 2036 dbSNP
rs1159081969 2044 dbSNP
rs1017089018 2049 dbSNP
rs1421937629 2065 dbSNP
rs1003980332 2069 dbSNP
rs912934282 2070 dbSNP
rs1402782920 2072 dbSNP
rs1237332134 2075 dbSNP
rs951236944 2077 dbSNP
rs562417018 2084 dbSNP
rs936259221 2085 dbSNP
rs542434371 2086 dbSNP
rs1355677767 2090 dbSNP
rs899490383 2091 dbSNP
rs1290835859 2096 dbSNP
rs1227769780 2097 dbSNP
rs573488438 2098 dbSNP
rs759781453 2100 dbSNP
rs774769687 2101 dbSNP
rs1000031555 2102 dbSNP
rs971999772 2105 dbSNP
rs1176653076 2108 dbSNP
rs553858323 2109 dbSNP
rs1376515197 2110 dbSNP
rs1442031056 2115 dbSNP
rs1159770946 2125 dbSNP
rs533911036 2129 dbSNP
rs1423104662 2131 dbSNP
rs1024456806 2134 dbSNP
rs1449477416 2134 dbSNP
rs1440839477 2139 dbSNP
rs973265571 2142 dbSNP
rs1378456178 2146 dbSNP
rs771416041 2151 dbSNP
rs1240866807 2153 dbSNP
rs945863828 2156 dbSNP
rs961443456 2166 dbSNP
rs1229771827 2176 dbSNP
rs1292329790 2181 dbSNP
rs1452335834 2182 dbSNP
rs1203935085 2193 dbSNP
rs1406506490 2193 dbSNP
rs879088283 2197 dbSNP
rs1016951336 2210 dbSNP
rs1005534091 2215 dbSNP
rs887708912 2217 dbSNP
rs1443198214 2220 dbSNP
rs1408754553 2221 dbSNP
rs1056544756 2231 dbSNP
rs1409068369 2236 dbSNP
rs1167873550 2251 dbSNP
rs373103995 2253 dbSNP
rs761513455 2254 dbSNP
rs571006187 2255 dbSNP
rs996091251 2256 dbSNP
rs926603729 2271 dbSNP
rs981036877 2273 dbSNP
rs1284516634 2278 dbSNP
rs1338495946 2287 dbSNP
rs1214276390 2292 dbSNP
rs1256366335 2295 dbSNP
rs1481509818 2297 dbSNP
rs945808437 2299 dbSNP
rs962924840 2307 dbSNP
rs185542194 2310 dbSNP
rs1441128894 2311 dbSNP
rs1190204919 2314 dbSNP
rs4850792 2322 dbSNP
rs1168908946 2332 dbSNP
rs1452176047 2334 dbSNP
rs1054067615 2336 dbSNP
rs935639624 2341 dbSNP
rs982973932 2342 dbSNP
rs926965368 2343 dbSNP
rs1353177554 2359 dbSNP
rs148619553 2360 dbSNP
rs1416165179 2370 dbSNP
rs951578224 2375 dbSNP
rs1325683535 2378 dbSNP
rs770442848 2380 dbSNP
rs1428362725 2388 dbSNP
rs747567935 2392 dbSNP
rs766629832 2395 dbSNP
rs950325945 2397 dbSNP
rs144885741 2398 dbSNP
rs1342956638 2402 dbSNP
rs917437845 2407 dbSNP
rs997911404 2408 dbSNP
rs145172474 2417 dbSNP
rs1017872369 2425 dbSNP
rs1017003899 2431 dbSNP
rs754499792 2439 dbSNP
rs1000083472 2442 dbSNP
rs1198226273 2447 dbSNP
rs1375497447 2451 dbSNP
rs12995665 2460 dbSNP
rs1478708454 2470 dbSNP
rs1173142628 2472 dbSNP
rs1417324237 2474 dbSNP
rs1359454812 2478 dbSNP
rs984194613 2482 dbSNP
rs904471327 2485 dbSNP
rs1360909063 2486 dbSNP
rs1020155575 2505 dbSNP
rs954210955 2506 dbSNP
rs1329466915 2508 dbSNP
rs1028323783 2511 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 23451.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000335508.6 | 3UTR | UAGCAAAUACUUAAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-4639-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT063335 ETNK1 ethanolamine kinase 1 2 2
MIRT077667 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT080431 NARS asparaginyl-tRNA synthetase 2 2
MIRT130192 TXNIP thioredoxin interacting protein 2 2
MIRT132966 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT138729 MPP5 membrane palmitoylated protein 5 2 2
MIRT152230 ZNF460 zinc finger protein 460 2 2
MIRT197361 ZNF652 zinc finger protein 652 2 2
MIRT282675 SYNM synemin 2 2
MIRT292617 CEBPG CCAAT/enhancer binding protein gamma 2 6
MIRT314026 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 2
MIRT325195 PSAT1 phosphoserine aminotransferase 1 2 2
MIRT329855 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT336755 ZNF678 zinc finger protein 678 2 2
MIRT445350 ARSK arylsulfatase family member K 2 2
MIRT456953 EDARADD EDAR associated death domain 2 6
MIRT467718 SLC38A1 solute carrier family 38 member 1 2 2
MIRT468229 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT474606 KLF3 Kruppel like factor 3 2 2
MIRT476880 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT494065 DUSP2 dual specificity phosphatase 2 2 4
MIRT496020 ZBED3 zinc finger BED-type containing 3 2 2
MIRT496201 EFCAB1 EF-hand calcium binding domain 1 2 2
MIRT499084 ZDHHC21 zinc finger DHHC-type containing 21 2 4
MIRT507188 FZD9 frizzled class receptor 9 2 6
MIRT513283 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT526260 CCDC169 coiled-coil domain containing 169 2 2
MIRT527080 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT528231 SPIN4 spindlin family member 4 2 2
MIRT529764 SF3B1 splicing factor 3b subunit 1 2 2
MIRT530881 SLC18A2 solute carrier family 18 member A2 2 2
MIRT531217 IFNGR2 interferon gamma receptor 2 2 2
MIRT532602 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT533026 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT536151 MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 2 2
MIRT536895 HEPHL1 hephaestin like 1 2 2
MIRT537051 GPR180 G protein-coupled receptor 180 2 2
MIRT537756 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538736 CALM1 calmodulin 1 2 2
MIRT544276 SEC63 SEC63 homolog, protein translocation regulator 2 2
MIRT546468 SLC1A5 solute carrier family 1 member 5 2 2
MIRT548128 GAS1 growth arrest specific 1 2 2
MIRT548406 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT556717 KLHL21 kelch like family member 21 2 4
MIRT559767 ABHD13 abhydrolase domain containing 13 2 2
MIRT566192 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT566665 NACC2 NACC family member 2 2 2
MIRT573194 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT628350 CCDC117 coiled-coil domain containing 117 2 2
MIRT630464 FOXP1 forkhead box P1 2 2
MIRT645825 INADL PATJ, crumbs cell polarity complex component 2 2
MIRT646288 GPX6 glutathione peroxidase 6 2 2
MIRT646332 ZNF37A zinc finger protein 37A 2 2
MIRT653169 SPPL3 signal peptide peptidase like 3 2 2
MIRT653302 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT654443 RASAL2 RAS protein activator like 2 2 2
MIRT697598 YAP1 Yes associated protein 1 2 2
MIRT699238 SLC6A8 solute carrier family 6 member 8 2 2
MIRT699887 RUNX1 runt related transcription factor 1 2 2
MIRT707267 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT708240 ZNF160 zinc finger protein 160 2 2
MIRT723227 FAM91A1 family with sequence similarity 91 member A1 2 2
MIRT725078 VCPIP1 valosin containing protein interacting protein 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4639-5p Cisplatin approved 84093 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4639 Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4639-5p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-4639-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4639-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)

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