miRTarBase - #MIRT529787


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pre-miRNA Information
pre-miRNA hsa-mir-4703   
Genomic Coordinates chr13: 51552589 - 51552667
Description Homo sapiens miR-4703 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4703-3p
Sequence 49| UGUAGUUGUAUUGUAUUGCCAC |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1460841833 5 dbSNP
rs775733304 5 dbSNP
rs756076492 10 dbSNP
rs1378936855 11 dbSNP
rs1049480258 12 dbSNP
rs555347919 13 dbSNP
rs1343138432 18 dbSNP
rs1011011214 19 dbSNP
rs1008216326 21 dbSNP
rs1238676458 22 dbSNP
Putative Targets

Gene Information
Gene Symbol AP4S1   
Synonyms AP47B, CLA20, CLAPS4, CPSQ6, SPG52
Description adaptor related protein complex 4 sigma 1 subunit
Transcript NM_001128126   
Other Transcripts NM_007077   
Expression
Putative miRNA Targets on AP4S1
3'UTR of AP4S1
(miRNA target sites are highlighted)		 
>AP4S1|NM_001128126|3'UTR
   1 AAGGAAGTCTCTTCGAGACAATATGGATTTATCAGAAATGCGAGTACCGTGGAATACATCTCAACATGTTAACCCAGAAG
  81 AATCTGGAAGACCACAATTACAAAATGGGGTATCCTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAAAAAG
 161 AAAACACAACTGTACTTTAAAATATGTACAAAGAAAAAAATTTCTTTAAACTGAGAGAGAAGTTTTATTTTCTAATTGTA
 241 AACATATCTGTCGCACTTTAAATTCTGTTGAGCACCTAAGGAACCCTTCTTGGTCTATGCTTCTTTTGCAAATTGAATTC
 321 AGGAATAGCAGGATGGTAGTGGGAAGAAAGTATGGCAGTTTTCCGTCAGCCAATAAAGTTTTAAAATTTAAACACAAGGC
 401 ATTTTGAGTAACGCTGTTTTCTGAAAGCTATTTTTTTTTTTTTGAGACGGAGTCTAGTCTAGCTGTGTCACCTGGCACAT
 481 TCTCGGCTCACTGCAACCTCCACTTCCGGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGAGCTGGGACTACAGGCATGC
 561 ACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGTCTCAAACTCCTGA
 641 CCTCAGGTGATCTGCCTGCCTCAGCCTCCCAGAACGCTGGGATTACAGATGAGCCACAGTGCCTGACTTCTGAAGGCTGT
 721 CTTATTCCTTTAAAAGGCTTAGTAAAATTAACTTTTTAAGAGGTGTTTTTTTGTTTGTTTTTTTGTTTTGTTTTTTAAGA
 801 CGGAGTCTTGCTCTGTCACCCAAGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCCACCTCTGGGTTTAAGC
 881 AATTCTCCTGCCTCAGCCTCCTGAGTAGCTGCGACTACAGGCATGTAGTCCCCAGGAGACTGAGCTGTGATTACAGATGT
 961 GAGCCACCATGCCCTGCCCGGTTTTATGTAAAGCCCAGCTAATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTT
1041 GGCCAGGCTGTTCTTGAACTCCTGACCTCAAGTGATCCACCTGCTTCAGCCTCCCAAAGTGCTGGGATTACAAGCATGAG
1121 CCACCATGCCCAGCCAAGAGGTGTTTTTTGTTTGTTTGTTTTTAAGAGAAGCAGGTCTTGCTGTGTTGTCCAGGCTGGAC
1201 TGCAGTGGCTTTTCACAAGCATGATCATGTTGTACTACAACCTTGAACCTTCCTGGCCTGGCTCTAAAAGCTTTGTAATG
1281 TGGGGCTGGTGCAGTGCCTCACACCTGTAACCCCTGCACTTTGGGAGGCTGAGGAAGGAGGATCGCTTGAGGCCAGAAAT
1361 TCAAGACCAGCCTGGGCAACATAGACCTCATCTCTACAAAAAATGCAAAAATCAGCCGGGTGTGGTGGCACATACCTGTA
1441 GTCTCAACTACTCGGGAGTCTGAGGCAGAAGATTTCTTGAGCCCAGGAGTTCGAGTCTGCAGTGAGCTATGATCGTGTCA
1521 CTGCACTCCAGCCTGGGTGACAGAGTGAAACCCTGTCTCAAAAATAAAAAAGTCCGAGTGCGGTGGCTCAGGCCTGTAAT
1601 CCCAACATTTTGGGGGGCCAAGCCAGGAGGATTGGTTGAGCCCATTAGTTCAAGACCAGCCTGGGCAACACAGCAAGACC
1681 ATATCTCTACAAAAAATAAATAGGTGTGATGGCTCATGCCTGTAATCCTAGTACTTTGGGAGGCCGAGGCAGGCAGATCA
1761 CTTGAGGTCAGGAGTTTGAAACCAGCCTGGCCAACATGGCAAAACCTTGTCTCTACTAAAAATACAAAAAGTTAGCCAGG
1841 CATGGTGGCAAGCACCTCTAATCTCAGCTACTCAGGAGGCTGAGGCAGTAGAATTGCTTGAACCCGGGAGGCAGAGGTTG
1921 CAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACCCTGTCTCTAAAAATAAGTAAATAACTA
2001 ATTAAAAAGTTAGCCAGCTGTGGTGGTGAGCACCTGTACTCCTAACTACTCAAGAGGCTGAGATGGGAGAATTGATCAAG
2081 CCTAGGAGTTTGAGGCTGCAGTGAACTATGATCACAACACTGTACTCCAACCTGGGTAATGGAGTGAGGCCCTGCCTCAA
2161 AAACACAAAAACAAAACAAAAAAACTTTTATAACATGTACCTAACAAAGATGCAGAGTTAAATTTTATTTGCCAGTTTGT
2241 AAAAGCCTTTGATACTCATTTTAAGGGCACTTAGTAATTACAATGCCATTATGTAATTAACTCTATAGAGAACATTACTT
2321 TCAAATAATGGATGGTCAGACATTAAGACAGCCCCAGAGAGCCCCTACAGCTATCCTTTATCCCGTTTTTTGTTTGTTTT
2401 TTGGAGACAGCATCTCCGTCTCCTAGGCTGGAGTGCAGTGGTGTGATCATGCCTCACTACAGCCTGTACCTCCTGGGCTC
2481 AGGTGCTCCTCCCACCTCAGCCTCCTGAGTAACTGGGACCACAGGTGCGCACCCCCTCCACCCAGCTAATTTTTGTATTT
2561 TGTTGTAGAGATAGGGTTTCACTATGTTGCCCAGACTGGTCTCGAATTCCTGCAGTCACATGATCCATCTGCCTTCGCCT
2641 TCCAAAGTGTTGGGATTACAGGCCTGAGCCACTGTGCCCAGTCTTTTTATGCCACATTTTAAAAGGTTTGCTTATTAATA
2721 AGCTTACTGTTAATGAAATTTAGTTCAAAGTTTAAAAGTAGAATGCAGCCAGGCATGGTGGCTTACGCCTATAATCCCAG
2801 CACTTTGGGACGCCAAGGTGGGTAGATCATTTGAGGTCAGGAGTTCAAGACCAGCTTGGCCAACATGGTGAGACCCTGTC
2881 TCTACTAAAACTACGAAAAATTAGCCGGGCATGGTGGCACGCGCCTATAATCCCAACTACTTGGGAGGCTGTGGTAGGAG
2961 GATCACTTGAACCCAGGAGACAGAGGTTGCAGTGAGTTGAGATCGAGATTGTGCCACTGCACTCCAGCCTGGGCACAGAG
3041 TGAGATTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAGTAGAAAGCAAGAAAGTGTCTCTGTACAGGTAGGCATGAAATGA
3121 ATCCTTCTCTTCCTCCCCTTTACTCCTTTAACCCCTTCTCCTGCAATGTCTTGAAGTAAATTACTGTCATTACAGAAGAG
3201 CAATGCACTGCATCCCCCCAAAACCTTTCTATATGCTTTTGCTACCCCGTTAACAGAAGAATATACAGAACTGTCTTAGG
3281 CGAAAGTATGTACAGTAGTCCCTCTCTTATCCACTGTTTCGCATTCTGTGGTTTGTGTTACTCATGGTCAACTGAGGTCC
3361 CAAAATATTAAACAGAAAATTCCAGAAATAAACAATGTATAAGTTTTAAACTGCAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caCCGU-UAUG----UUA-UGUUGAUGu 5'
            |||| ||||    |:|  ||||||| 
Target 5' gtGGCACATACCTGTAGTCTCAACTACt 3'
 1425 - 1452 158.00 -15.40
2 
miRNA  3' caCCGU-----UAUGUUA-UGUUGAUGu 5'
            ||||      ||:|||  ||||||| 
Target 5' gtGGCACGCGCCTATAATCCCAACTACt 3'
 2914 - 2941 156.00 -14.70
3 
miRNA  3' caCCGUU-----AUGUUA-UGUUGAUGu 5'
            |||||     | :|||  ||:|||| 
Target 5' gtGGCAAGCACCTCTAATCTCAGCTACt 3'
 1845 - 1872 140.00 -14.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31562563 42 COSMIC
COSN25481963 415 COSMIC
COSN24476207 445 COSMIC
COSN27035554 450 COSMIC
COSN1644613 461 COSMIC
COSN1166782 1298 COSMIC
COSN30424901 1539 COSMIC
COSN28519520 1550 COSMIC
COSN9612288 1719 COSMIC
COSN15794977 1732 COSMIC
COSN1644614 2052 COSMIC
COSN5171088 2387 COSMIC
COSN8827789 2735 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1167407572 3 dbSNP
rs1003668011 4 dbSNP
rs780204446 15 dbSNP
rs747159143 16 dbSNP
rs1282722602 18 dbSNP
rs1308203758 25 dbSNP
rs1206827310 26 dbSNP
rs1249864254 28 dbSNP
rs1480472299 37 dbSNP
rs1223701032 40 dbSNP
rs562107578 42 dbSNP
rs994034106 43 dbSNP
rs1177725519 44 dbSNP
rs768889951 45 dbSNP
rs1456301596 47 dbSNP
rs762381475 47 dbSNP
rs781612065 49 dbSNP
rs1167835052 50 dbSNP
rs1287126946 67 dbSNP
rs952668391 68 dbSNP
rs1353393537 69 dbSNP
rs1310654272 87 dbSNP
rs1359302019 106 dbSNP
rs1449567834 110 dbSNP
rs1310483098 117 dbSNP
rs1375123067 127 dbSNP
rs1006960587 135 dbSNP
rs1441916529 138 dbSNP
rs1355391226 140 dbSNP
rs574069118 142 dbSNP
rs965081893 145 dbSNP
rs1280518877 149 dbSNP
rs1338878714 161 dbSNP
rs1385532440 170 dbSNP
rs1214243379 171 dbSNP
rs1157945524 175 dbSNP
rs9181 184 dbSNP
rs1396644860 185 dbSNP
rs1194100829 186 dbSNP
rs923707686 187 dbSNP
rs1244631769 191 dbSNP
rs957066409 200 dbSNP
rs1284733826 203 dbSNP
rs1208124840 207 dbSNP
rs989663983 209 dbSNP
rs747225011 213 dbSNP
rs1220193536 218 dbSNP
rs1485321504 218 dbSNP
rs1367113626 220 dbSNP
rs948362195 235 dbSNP
rs1433206866 241 dbSNP
rs538908686 244 dbSNP
rs1474301574 245 dbSNP
rs533194453 247 dbSNP
rs1425450065 248 dbSNP
rs533578688 251 dbSNP
rs1377200752 253 dbSNP
rs939403564 254 dbSNP
rs1171238056 262 dbSNP
rs1234206517 273 dbSNP
rs1187870195 279 dbSNP
rs1036418711 282 dbSNP
rs1374275135 285 dbSNP
rs1190889725 286 dbSNP
rs1487563119 289 dbSNP
rs897913222 298 dbSNP
rs1211213357 300 dbSNP
rs551633561 303 dbSNP
rs1300557025 311 dbSNP
rs138436477 318 dbSNP
rs888359191 321 dbSNP
rs1006834113 336 dbSNP
rs1398244435 341 dbSNP
rs1357231464 345 dbSNP
rs1303386191 354 dbSNP
rs1447247328 363 dbSNP
rs1017883750 364 dbSNP
rs1275748721 365 dbSNP
rs528015875 366 dbSNP
rs1232313688 374 dbSNP
rs1302794247 389 dbSNP
rs549248882 395 dbSNP
rs964988861 413 dbSNP
rs1167861509 414 dbSNP
rs748698695 414 dbSNP
rs1217298009 421 dbSNP
rs1288060006 427 dbSNP
rs1207068035 431 dbSNP
rs1257686414 431 dbSNP
rs34042875 431 dbSNP
rs397853202 431 dbSNP
rs71430917 431 dbSNP
rs1216828819 437 dbSNP
rs1445153538 444 dbSNP
rs1390630462 445 dbSNP
rs1247029508 448 dbSNP
rs1478820598 449 dbSNP
rs867969357 450 dbSNP
rs1030667613 458 dbSNP
rs1447281824 459 dbSNP
rs1394001044 479 dbSNP
rs1439763322 482 dbSNP
rs1161031436 483 dbSNP
rs1368529659 485 dbSNP
rs1383449518 486 dbSNP
rs1400565794 508 dbSNP
rs1324651693 509 dbSNP
rs547778750 519 dbSNP
rs1351932070 520 dbSNP
rs1439043228 534 dbSNP
rs1196956524 535 dbSNP
rs1325437253 536 dbSNP
rs1266042969 540 dbSNP
rs956488571 541 dbSNP
rs372917352 544 dbSNP
rs1309104420 548 dbSNP
rs1375850346 550 dbSNP
rs1306882460 557 dbSNP
rs990046270 561 dbSNP
rs1391006822 572 dbSNP
rs915449989 575 dbSNP
rs1377816274 582 dbSNP
rs1348606879 591 dbSNP
rs375961736 597 dbSNP
rs781711129 601 dbSNP
rs9944147 601 dbSNP
rs545222550 603 dbSNP
rs1435072190 622 dbSNP
rs1209279249 623 dbSNP
rs1487529109 624 dbSNP
rs1262618642 627 dbSNP
rs1217233212 631 dbSNP
rs1352986177 632 dbSNP
rs1277784299 651 dbSNP
rs1236236033 657 dbSNP
rs1331276794 666 dbSNP
rs1300203357 673 dbSNP
rs549863056 677 dbSNP
rs1384753189 692 dbSNP
rs928214876 704 dbSNP
rs1348495503 712 dbSNP
rs1223097361 717 dbSNP
rs1360469090 725 dbSNP
rs1290393799 732 dbSNP
rs1453087689 737 dbSNP
rs369281244 753 dbSNP
rs939295352 753 dbSNP
rs1198398510 754 dbSNP
rs1265424085 764 dbSNP
rs1431719974 764 dbSNP
rs372479769 764 dbSNP
rs760807779 766 dbSNP
rs972067173 766 dbSNP
rs1283825836 770 dbSNP
rs373498601 770 dbSNP
rs572123734 770 dbSNP
rs930784612 776 dbSNP
rs1255239818 777 dbSNP
rs1048687796 778 dbSNP
rs1308957429 778 dbSNP
rs1179973541 780 dbSNP
rs1278215418 786 dbSNP
rs1398876204 799 dbSNP
rs772601151 802 dbSNP
rs183110847 803 dbSNP
rs1398355279 807 dbSNP
rs1039574343 811 dbSNP
rs1172427935 824 dbSNP
rs901097472 832 dbSNP
rs377502364 837 dbSNP
rs997771125 839 dbSNP
rs560246813 840 dbSNP
rs536438717 860 dbSNP
rs1477553970 862 dbSNP
rs1261176183 863 dbSNP
rs1189501026 873 dbSNP
rs1325582014 882 dbSNP
rs1255208282 885 dbSNP
rs1401310076 895 dbSNP
rs1198517108 896 dbSNP
rs565872617 897 dbSNP
rs1458782966 905 dbSNP
rs1449228043 912 dbSNP
rs1217686569 914 dbSNP
rs1315512004 919 dbSNP
rs1489527015 927 dbSNP
rs1294657552 929 dbSNP
rs144547531 931 dbSNP
rs1326956483 936 dbSNP
rs1341599831 957 dbSNP
rs1335221460 962 dbSNP
rs1394673722 963 dbSNP
rs1402674161 970 dbSNP
rs1332257064 974 dbSNP
rs1441436117 978 dbSNP
rs1421557175 980 dbSNP
rs188578257 981 dbSNP
rs1473046358 987 dbSNP
rs1367844296 1000 dbSNP
rs574107874 1008 dbSNP
rs1185094510 1009 dbSNP
rs1284701191 1023 dbSNP
rs1238614450 1024 dbSNP
rs1197614512 1025 dbSNP
rs892205851 1028 dbSNP
rs1209930553 1035 dbSNP
rs1357608942 1043 dbSNP
rs1284154019 1047 dbSNP
rs1243299643 1050 dbSNP
rs1010678340 1051 dbSNP
rs1310524401 1060 dbSNP
rs1446318841 1061 dbSNP
rs1231246548 1062 dbSNP
rs1325539601 1066 dbSNP
rs1272243825 1076 dbSNP
rs770226582 1088 dbSNP
rs780111846 1090 dbSNP
rs1441532600 1097 dbSNP
rs1380683469 1100 dbSNP
rs1177781828 1102 dbSNP
rs765793677 1108 dbSNP
rs879766221 1110 dbSNP
rs1198900781 1127 dbSNP
rs774101161 1131 dbSNP
rs1287185904 1135 dbSNP
rs544236137 1142 dbSNP
rs1197132668 1144 dbSNP
rs1247867223 1147 dbSNP
rs1356550430 1147 dbSNP
rs969554498 1156 dbSNP
rs1436692697 1157 dbSNP
rs1371409020 1174 dbSNP
rs980954865 1182 dbSNP
rs1239737018 1186 dbSNP
rs1035237389 1190 dbSNP
rs960982104 1193 dbSNP
rs1474474419 1197 dbSNP
rs1421373458 1201 dbSNP
rs1164696111 1205 dbSNP
rs527600463 1217 dbSNP
rs1157779443 1221 dbSNP
rs972057313 1228 dbSNP
rs1427051735 1234 dbSNP
rs1424724004 1235 dbSNP
rs919289016 1240 dbSNP
rs1477523130 1249 dbSNP
rs1166335513 1257 dbSNP
rs1395941494 1258 dbSNP
rs1415092902 1271 dbSNP
rs1336189528 1272 dbSNP
rs116165906 1274 dbSNP
rs1412819965 1276 dbSNP
rs984865607 1278 dbSNP
rs1315484068 1283 dbSNP
rs910648623 1286 dbSNP
rs1281240988 1289 dbSNP
rs578070007 1293 dbSNP
rs193137329 1295 dbSNP
rs1229206213 1319 dbSNP
rs1249257285 1321 dbSNP
rs1039517972 1345 dbSNP
rs114616794 1346 dbSNP
rs1297468773 1352 dbSNP
rs185657107 1353 dbSNP
rs1281792553 1382 dbSNP
rs187784292 1383 dbSNP
rs1187830835 1388 dbSNP
rs1264394085 1389 dbSNP
rs1430655239 1390 dbSNP
rs1176602636 1392 dbSNP
rs1191369893 1398 dbSNP
rs1422637882 1398 dbSNP
rs531500672 1419 dbSNP
rs1477879004 1421 dbSNP
rs1422356523 1423 dbSNP
rs1193559356 1429 dbSNP
rs1485216855 1432 dbSNP
rs148022542 1433 dbSNP
rs1174423585 1434 dbSNP
rs1442011909 1446 dbSNP
rs143642538 1449 dbSNP
rs1432842443 1454 dbSNP
rs1277707035 1455 dbSNP
rs764028668 1463 dbSNP
rs1361005242 1465 dbSNP
rs754385701 1467 dbSNP
rs1303153428 1474 dbSNP
rs904945019 1482 dbSNP
rs1293091790 1493 dbSNP
rs1002366418 1494 dbSNP
rs1035227588 1496 dbSNP
rs960931113 1502 dbSNP
rs1167922477 1512 dbSNP
rs972373771 1515 dbSNP
rs1305052051 1516 dbSNP
rs1182767271 1522 dbSNP
rs1472657866 1534 dbSNP
rs1345077245 1539 dbSNP
rs571219943 1544 dbSNP
rs1210875515 1550 dbSNP
rs1200742621 1560 dbSNP
rs1458432339 1560 dbSNP
rs1287348685 1561 dbSNP
rs1257424585 1566 dbSNP
rs1487101052 1569 dbSNP
rs1203763451 1570 dbSNP
rs1026997531 1576 dbSNP
rs532149736 1577 dbSNP
rs879146158 1578 dbSNP
rs985201385 1582 dbSNP
rs1380292595 1583 dbSNP
rs1393392958 1588 dbSNP
rs115020623 1593 dbSNP
rs779979366 1599 dbSNP
rs1399115364 1600 dbSNP
rs1172998576 1602 dbSNP
rs1350006419 1603 dbSNP
rs8004286 1607 dbSNP
rs1383765176 1611 dbSNP
rs975212661 1612 dbSNP
rs1440489612 1618 dbSNP
rs922461519 1631 dbSNP
rs1175513755 1633 dbSNP
rs1359204454 1638 dbSNP
rs1489487300 1641 dbSNP
rs1286922199 1642 dbSNP
rs1383940408 1645 dbSNP
rs1220738971 1651 dbSNP
rs1357198399 1654 dbSNP
rs1287822678 1664 dbSNP
rs1240632240 1679 dbSNP
rs1375650121 1682 dbSNP
rs1388204722 1684 dbSNP
rs1387032483 1688 dbSNP
rs933895867 1689 dbSNP
rs536426809 1697 dbSNP
rs1424507001 1704 dbSNP
rs8005747 1708 dbSNP
rs913826566 1710 dbSNP
rs1345897828 1716 dbSNP
rs1363625803 1719 dbSNP
rs1157164612 1729 dbSNP
rs781708317 1732 dbSNP
rs946364191 1743 dbSNP
rs1435200478 1745 dbSNP
rs748467829 1746 dbSNP
rs1232942168 1747 dbSNP
rs1489826464 1768 dbSNP
rs191301910 1771 dbSNP
rs1217302095 1772 dbSNP
rs1319288770 1776 dbSNP
rs1234952031 1796 dbSNP
rs1237458443 1797 dbSNP
rs537345297 1801 dbSNP
rs556321587 1802 dbSNP
rs577952581 1808 dbSNP
rs1299916925 1810 dbSNP
rs1260558452 1816 dbSNP
rs1344129115 1818 dbSNP
rs1300549881 1820 dbSNP
rs1488994778 1823 dbSNP
rs1384695974 1824 dbSNP
rs1287492611 1826 dbSNP
rs1215863938 1830 dbSNP
rs1251361344 1847 dbSNP
rs904941493 1851 dbSNP
rs1378450664 1853 dbSNP
rs1001978791 1857 dbSNP
rs545198645 1861 dbSNP
rs1056634041 1866 dbSNP
rs1194286373 1875 dbSNP
rs1446423988 1876 dbSNP
rs553820536 1885 dbSNP
rs770047896 1888 dbSNP
rs1201972369 1890 dbSNP
rs1483342818 1896 dbSNP
rs1252698123 1897 dbSNP
rs1221348096 1898 dbSNP
rs994091854 1905 dbSNP
rs1278340841 1906 dbSNP
rs371080479 1907 dbSNP
rs1420855947 1908 dbSNP
rs1326375659 1917 dbSNP
rs372406922 1923 dbSNP
rs1156799388 1930 dbSNP
rs1398192810 1931 dbSNP
rs1403411225 1940 dbSNP
rs376515661 1943 dbSNP
rs572321379 1948 dbSNP
rs1468490583 1960 dbSNP
rs183476460 1961 dbSNP
rs199545043 1965 dbSNP
rs952408223 1988 dbSNP
rs1475007358 1992 dbSNP
rs1371285357 1993 dbSNP
rs1189311599 2011 dbSNP
rs111287623 2027 dbSNP
rs1017597221 2037 dbSNP
rs1201368593 2039 dbSNP
rs1458818439 2042 dbSNP
rs114438582 2047 dbSNP
rs976164926 2050 dbSNP
rs188595451 2052 dbSNP
rs955184055 2054 dbSNP
rs1374853213 2066 dbSNP
rs1247692521 2073 dbSNP
rs1341437091 2078 dbSNP
rs1303683343 2079 dbSNP
rs1450632886 2081 dbSNP
rs1379406704 2083 dbSNP
rs147209299 2085 dbSNP
rs1306913882 2092 dbSNP
rs1322761097 2103 dbSNP
rs1409482583 2109 dbSNP
rs1394468768 2116 dbSNP
rs532113966 2120 dbSNP
rs1235546466 2123 dbSNP
rs1384372903 2131 dbSNP
rs1181539111 2140 dbSNP
rs1271588915 2142 dbSNP
rs1441105298 2145 dbSNP
rs1334468080 2151 dbSNP
rs765476704 2151 dbSNP
rs547539005 2153 dbSNP
rs1234712369 2158 dbSNP
rs1479695336 2163 dbSNP
rs1291480527 2168 dbSNP
rs1212153076 2169 dbSNP
rs1175465842 2173 dbSNP
rs1360795881 2174 dbSNP
rs1043381135 2178 dbSNP
rs1244262086 2178 dbSNP
rs1356070495 2186 dbSNP
rs1310221103 2199 dbSNP
rs1441814520 2200 dbSNP
rs1249746920 2212 dbSNP
rs1334043329 2218 dbSNP
rs926306901 2221 dbSNP
rs1325689008 2236 dbSNP
rs56205472 2237 dbSNP
rs937675727 2241 dbSNP
rs1364910137 2242 dbSNP
rs1161400354 2247 dbSNP
rs1380738589 2249 dbSNP
rs559458806 2250 dbSNP
rs1468344381 2258 dbSNP
rs558069257 2266 dbSNP
rs1198964821 2271 dbSNP
rs1490641063 2276 dbSNP
rs1415335113 2282 dbSNP
rs759204661 2286 dbSNP
rs1285462387 2293 dbSNP
rs1223427082 2301 dbSNP
rs1048393414 2304 dbSNP
rs888031015 2305 dbSNP
rs1224237363 2310 dbSNP
rs1006906542 2311 dbSNP
rs1301194645 2314 dbSNP
rs1401834514 2329 dbSNP
rs1170674488 2330 dbSNP
rs181089601 2335 dbSNP
rs1460015750 2336 dbSNP
rs1297052519 2343 dbSNP
rs1380537593 2352 dbSNP
rs1417109648 2353 dbSNP
rs1238444921 2355 dbSNP
rs1291876277 2356 dbSNP
rs964652651 2362 dbSNP
rs541066047 2364 dbSNP
rs140629816 2376 dbSNP
rs1219547882 2379 dbSNP
rs1030332593 2382 dbSNP
rs956326802 2383 dbSNP
rs1215550340 2385 dbSNP
rs1280962234 2386 dbSNP
rs1445455076 2386 dbSNP
rs1305922067 2389 dbSNP
rs1322904332 2391 dbSNP
rs987989490 2397 dbSNP
rs1220322063 2398 dbSNP
rs1362593935 2409 dbSNP
rs1269324068 2411 dbSNP
rs1021231257 2412 dbSNP
rs370912105 2418 dbSNP
rs536977806 2419 dbSNP
rs979316481 2427 dbSNP
rs185271539 2428 dbSNP
rs775271309 2442 dbSNP
rs1479055456 2448 dbSNP
rs1420889452 2454 dbSNP
rs571573136 2456 dbSNP
rs1485973478 2457 dbSNP
rs1474619814 2464 dbSNP
rs1212914208 2471 dbSNP
rs937623472 2474 dbSNP
rs991834150 2477 dbSNP
rs1461043502 2481 dbSNP
rs190174676 2497 dbSNP
rs1356513498 2506 dbSNP
rs929085108 2507 dbSNP
rs1186803939 2508 dbSNP
rs765202684 2514 dbSNP
rs1426297567 2526 dbSNP
rs1291597947 2529 dbSNP
rs553857552 2530 dbSNP
rs1380139863 2534 dbSNP
rs1169173761 2535 dbSNP
rs1332746627 2536 dbSNP
rs1375496839 2540 dbSNP
rs1047870385 2556 dbSNP
rs887970774 2560 dbSNP
rs1408786778 2566 dbSNP
rs1416327581 2570 dbSNP
rs1311585644 2571 dbSNP
rs796733391 2572 dbSNP
rs1039236074 2573 dbSNP
rs1180785835 2574 dbSNP
rs1375283664 2585 dbSNP
rs572161144 2586 dbSNP
rs1480985949 2591 dbSNP
rs900765546 2602 dbSNP
rs116479078 2604 dbSNP
rs1272221919 2605 dbSNP
rs1292157912 2608 dbSNP
rs112103141 2611 dbSNP
rs1010766283 2621 dbSNP
rs576564772 2623 dbSNP
rs1310972465 2626 dbSNP
rs150833264 2634 dbSNP
rs182291841 2637 dbSNP
rs866381096 2638 dbSNP
rs1213023265 2639 dbSNP
rs979264192 2647 dbSNP
rs1440576840 2648 dbSNP
rs1368030618 2650 dbSNP
rs576782004 2654 dbSNP
rs540989874 2667 dbSNP
rs959307598 2671 dbSNP
rs559385105 2678 dbSNP
rs991824207 2682 dbSNP
rs1485272431 2684 dbSNP
rs1383827673 2697 dbSNP
rs529853231 2697 dbSNP
rs917600093 2698 dbSNP
rs929059845 2701 dbSNP
rs983579218 2705 dbSNP
rs548289593 2708 dbSNP
rs1249820970 2711 dbSNP
rs139300982 2719 dbSNP
rs908981677 2724 dbSNP
rs1243594193 2729 dbSNP
rs1269475476 2731 dbSNP
rs150021659 2734 dbSNP
rs766512327 2740 dbSNP
rs1395228517 2741 dbSNP
rs529269503 2742 dbSNP
rs1315985945 2745 dbSNP
rs1220487545 2751 dbSNP
rs1304177126 2751 dbSNP
rs1345635970 2758 dbSNP
rs1304254473 2760 dbSNP
rs1404938447 2769 dbSNP
rs1171133158 2771 dbSNP
rs1395010716 2774 dbSNP
rs145249041 2783 dbSNP
rs141328354 2787 dbSNP
rs1156962346 2788 dbSNP
rs143821144 2788 dbSNP
rs1481447047 2789 dbSNP
rs1430145895 2794 dbSNP
rs187374941 2799 dbSNP
rs1022087723 2809 dbSNP
rs565727613 2810 dbSNP
rs191796764 2812 dbSNP
rs1232201496 2813 dbSNP
rs555027005 2814 dbSNP
rs1302680724 2815 dbSNP
rs1264992075 2817 dbSNP
rs1205528225 2818 dbSNP
rs752953002 2822 dbSNP
rs1258555383 2828 dbSNP
rs1211857735 2837 dbSNP
rs1224224447 2847 dbSNP
rs1286133943 2858 dbSNP
rs1314905496 2860 dbSNP
rs1214703585 2862 dbSNP
rs1253253320 2864 dbSNP
rs1000690921 2870 dbSNP
rs1223358099 2876 dbSNP
rs1344186663 2877 dbSNP
rs1298119250 2878 dbSNP
rs1033549289 2886 dbSNP
rs576584966 2888 dbSNP
rs1471117584 2889 dbSNP
rs537620264 2895 dbSNP
rs1251775644 2902 dbSNP
rs959260116 2907 dbSNP
rs1374758343 2908 dbSNP
rs1193866145 2909 dbSNP
rs1013539460 2912 dbSNP
rs36119846 2912 dbSNP
rs1259465292 2916 dbSNP
rs1024906380 2921 dbSNP
rs1400480570 2922 dbSNP
rs1261902734 2923 dbSNP
rs558999654 2924 dbSNP
rs1321982431 2936 dbSNP
rs1396969458 2937 dbSNP
rs983141294 2945 dbSNP
rs1438930897 2948 dbSNP
rs577569383 2952 dbSNP
rs908922340 2955 dbSNP
rs756549541 2958 dbSNP
rs1336392874 2962 dbSNP
rs963132192 2967 dbSNP
rs974879750 2976 dbSNP
rs1281196757 2986 dbSNP
rs1468273345 2999 dbSNP
rs1398795364 3000 dbSNP
rs1168408647 3002 dbSNP
rs1348380480 3008 dbSNP
rs922132642 3010 dbSNP
rs777968132 3018 dbSNP
rs933503946 3020 dbSNP
rs1165251963 3023 dbSNP
rs1418110134 3025 dbSNP
rs1242179003 3031 dbSNP
rs541733534 3047 dbSNP
rs180930883 3050 dbSNP
rs1052422247 3051 dbSNP
rs1196820607 3054 dbSNP
rs1250699838 3054 dbSNP
rs1261646037 3054 dbSNP
rs1161276615 3055 dbSNP
rs1178761010 3055 dbSNP
rs1329631583 3055 dbSNP
rs1331678518 3055 dbSNP
rs1337612519 3055 dbSNP
rs1390694593 3055 dbSNP
rs1394280492 3055 dbSNP
rs1425028862 3055 dbSNP
rs1450807396 3055 dbSNP
rs1470960573 3055 dbSNP
rs768539772 3055 dbSNP
rs796720649 3055 dbSNP
rs913485373 3055 dbSNP
rs1211409073 3056 dbSNP
rs1272038176 3058 dbSNP
rs1437904166 3059 dbSNP
rs1184677926 3060 dbSNP
rs1180495262 3074 dbSNP
rs946002693 3074 dbSNP
rs1043094790 3075 dbSNP
rs1490610570 3077 dbSNP
rs71430918 3077 dbSNP
rs904601256 3078 dbSNP
rs1353129987 3079 dbSNP
rs61976857 3079 dbSNP
rs1189136895 3081 dbSNP
rs1420413069 3082 dbSNP
rs1460117921 3083 dbSNP
rs185203729 3091 dbSNP
rs1164470913 3094 dbSNP
rs541581208 3104 dbSNP
rs563359779 3105 dbSNP
rs1364655873 3120 dbSNP
rs1397372996 3123 dbSNP
rs1402032444 3130 dbSNP
rs1001645249 3134 dbSNP
rs112716421 3139 dbSNP
rs1326858144 3144 dbSNP
rs1333936884 3147 dbSNP
rs1468134138 3152 dbSNP
rs190361073 3158 dbSNP
rs1409081726 3167 dbSNP
rs1293729209 3169 dbSNP
rs1430859975 3176 dbSNP
rs1202227226 3178 dbSNP
rs201473308 3181 dbSNP
rs894954181 3205 dbSNP
rs750718606 3207 dbSNP
rs1285180229 3214 dbSNP
rs1448918942 3214 dbSNP
rs1204825713 3216 dbSNP
rs527849090 3220 dbSNP
rs1285276800 3227 dbSNP
rs541639126 3229 dbSNP
rs1223980716 3230 dbSNP
rs1197043999 3232 dbSNP
rs1344827124 3238 dbSNP
rs1272814605 3239 dbSNP
rs756644366 3240 dbSNP
rs1025274503 3244 dbSNP
rs1326854346 3246 dbSNP
rs1317174340 3247 dbSNP
rs534239880 3249 dbSNP
rs528410445 3250 dbSNP
rs1176543419 3255 dbSNP
rs1470563060 3256 dbSNP
rs930732086 3256 dbSNP
rs1190023075 3265 dbSNP
rs1476581784 3273 dbSNP
rs1015970484 3282 dbSNP
rs544740770 3283 dbSNP
rs1463723853 3290 dbSNP
rs1204419747 3294 dbSNP
rs963084703 3301 dbSNP
rs555997108 3304 dbSNP
rs565766357 3309 dbSNP
rs182621438 3311 dbSNP
rs1373862204 3312 dbSNP
rs1384576935 3314 dbSNP
rs954836560 3314 dbSNP
rs987663487 3315 dbSNP
rs1451242723 3321 dbSNP
rs73253817 3322 dbSNP
rs946356234 3336 dbSNP
rs1412194759 3343 dbSNP
rs570096918 3352 dbSNP
rs1167719404 3353 dbSNP
rs1245163008 3374 dbSNP
rs73253818 3374 dbSNP
rs1184489002 3376 dbSNP
rs1460916098 3384 dbSNP
rs1313407376 3385 dbSNP
rs1206450979 3386 dbSNP
rs1308023395 3400 dbSNP
rs1377110060 3400 dbSNP
rs1271967459 3411 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 11154.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' caccGUUAUG--UUAUGU-UGaugu 5'
              ||:||:  :| ||| ||    
Target 5' --caCAGUAUGGGAGACACACc--- 3'
 		1 - 20
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000334725.4 | 3UTR | CACAGUAUGGGAGACACACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
42 hsa-miR-4703-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT072026 SCP2 sterol carrier protein 2 2 2
MIRT079071 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT106648 PLEKHF2 pleckstrin homology and FYVE domain containing 2 2 4
MIRT178174 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT190328 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT230081 SH3BGRL SH3 domain binding glutamate rich protein like 2 2
MIRT238900 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT473705 MAPK1 mitogen-activated protein kinase 1 2 6
MIRT481891 ANKRD46 ankyrin repeat domain 46 2 4
MIRT483743 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT488823 MRRF mitochondrial ribosome recycling factor 2 2
MIRT488990 SLC28A1 solute carrier family 28 member 1 2 2
MIRT504173 FAM127B retrotransposon Gag like 8A 2 2
MIRT524461 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT529787 AP4S1 adaptor related protein complex 4 sigma 1 subunit 2 2
MIRT546449 SLC9A7 solute carrier family 9 member A7 2 2
MIRT547827 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT561462 TCERG1 transcription elongation regulator 1 2 2
MIRT562315 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT563644 ZNF675 zinc finger protein 675 2 2
MIRT563741 ZNF107 zinc finger protein 107 2 4
MIRT568318 BACH1 BTB domain and CNC homolog 1 2 2
MIRT571528 ZNF367 zinc finger protein 367 2 2
MIRT574840 CADM1 cell adhesion molecule 1 2 2
MIRT612262 MNT MAX network transcriptional repressor 2 4
MIRT622234 SLC25A45 solute carrier family 25 member 45 2 2
MIRT625372 IRGQ immunity related GTPase Q 2 2
MIRT628260 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT631738 NKX2-1 NK2 homeobox 1 2 2
MIRT646103 GORAB golgin, RAB6 interacting 2 2
MIRT647768 AMOTL1 angiomotin like 1 2 2
MIRT654309 RBMS3 RNA binding motif single stranded interacting protein 3 2 2
MIRT654988 PLCG2 phospholipase C gamma 2 2 2
MIRT659715 CCDC93 coiled-coil domain containing 93 2 2
MIRT666976 PHAX phosphorylated adaptor for RNA export 2 2
MIRT683247 WFDC6 WAP four-disulfide core domain 6 2 2
MIRT688424 DNAL1 dynein axonemal light chain 1 2 2
MIRT691896 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT701616 MYO1B myosin IB 2 2
MIRT702141 MAP3K1 mitogen-activated protein kinase kinase kinase 1 2 2
MIRT704403 CTPS1 CTP synthase 1 2 2
MIRT719515 RAB10 RAB10, member RAS oncogene family 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4703 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4703-3p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4703-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4703-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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