miRTarBase - #MIRT530096


—
pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol PSAPL1   
Synonyms -
Description prosaposin like 1 (gene/pseudogene)
Transcript NM_001085382   
Expression
Putative miRNA Targets on PSAPL1
3'UTR of PSAPL1
(miRNA target sites are highlighted)		 
>PSAPL1|NM_001085382|3'UTR
   1 CCGTGGCTGCCAGAGACCCAGAGCCTGCTAGCGAGGCCCATGAGGTGGGTGCTTTCCCCATCCCCATTTCACAAATGAAA
  81 AACTGAAGCTCTGAGGAGGGAGGCTGGGAAGGAGCAGAGCTGAAGTTCAAAACCAAGTATTCCTGATCCCGAAAGCCTCT
 161 CTCTTAACAACGGTGCCGCACAGCTTTGCCCTTGAAAGCATCTCTACTGGACCGGAACACACTCATGTGCCCCGCTCCCT
 241 GACCCAGCCAAGGCTGCCCTCTCATCTCCAAGGCTGAGATGTTGCCGGTGGTCCCATGAGAGCCTGCCCATGGGCTCAGG
 321 TGCCCCTTTACCTTCTGCTGGATGGACATCTGGCTGTGAGCCAGGCTGGGGTCATGGCCGGGGTGAGCGGAGGCAGGGGT
 401 GGACGGAGGCTTCGAGGGCCCATCACTAGTAGGGTCATTACCTCTTGCCAACAGCCGGGGGTGGGAGTCTGGGTCTCGCT
 481 CAGGCCAGAGCTTCTCAACCTGGAGTCCCTGGGGGTGGCTGCCAAAGGTGTGTATGACAAGCACGTATCCCTGGACATTT
 561 CCGGGGAGAGGTCTGGGGCTTTGGTCACATTCTCCAAGGGCTGCTGGGCTTCGGAGCAGTCCCCCCCCATGTCTCAGCCA
 641 CTACAGGGTCCCTCTCTCTCCTTGCACCCCAGACCCTCCGCTGCCCTGGTAATGAGCAGAAGGAAAGTCTTGGGGTGTGC
 721 TCAAAGTCAGGAGAGCAAAATATGCCAGGCAAAAGCTCCCGGGAAAAGCCGGAGGAGTCTGGGGTGGCCACCGGGATGTG
 801 GAGCAGCGAGGGCAAAGACGGTGAACACAGCCCTCCAGCTGTCTGAGCCTCAGTTTTCTAATCTGTAGAATGGGGATGAT
 881 CATACCTGCCTCACAAGAATGTTGAGACAATTCACAGAGACGTTCTGGAGCCCCTTTCCCCCGAGACCGGCATTCATGAG
 961 TCTGCTGGGACCAGAAAACCCATCTCAGGGGCCCAGCGGGGCACCCAGGAGAGTCTGGCGGTGCAAGCGCTGTATAAACC
1041 ACAAGCGTTCTCCAAATGCCGTGTGCCGTGTTTTTATTCTCAGGGAAGGCGCAGATCCCAGAGCTGCTACAACAGCCTCC
1121 ACCTTACCCTGGTGCCTCCACCTCGCCCCGGTGCCCCCTCTGGCAGAAAGCCTCCGGGGGGGGTTTCCATCTGGGTTCAA
1201 GTGCTCCTGTGGTTTCTGCTCCTGCTGTTTGGCCCCCCTAAGACACTGTGCCCCCTCCAGGAGAGCCCCTGGGCATGACC
1281 CTGCAGTGTCCTTGCAGCTGGCCCAGCATCTGCACGCAGCAGGTGCTCACACATCTGGGAGCCGCACACATGAGTCCCGG
1361 GGGTGGAAGCTGGTATTTCACCTGAGGCCCATGGATTAATTCTCCTCTTGAGTAAGAGGTGCGCCAGGCCTGGATGGACG
1441 GGATGTGAGCGGGTGCTGTTTTCCAAGAGGCCACACCCGAGCTCTTAAGTAAACGTCGCAGACCTGGGCCACCGCCCCAG
1521 GAACACAGGCACACTGGGCCTGAGATTCTGGATGCCTCAGAAGTGGCCCCTATTGGCTGGGCAGGCCTGGGCCCGCTGGG
1601 CAGTCCCACAAAAGATAAGGCCAGCAAGGGGTGGTGGTCGTGCCTGGCCACCGGATGGGCCATGGGAAGGCAGCTCTGCA
1681 CCAGACTCCAAAACACAGGGGCCCGAAGTTGTTGGCCTCAGTATCTGCCTCTTCCCCTGAGACCACCCACCCTCTCCAGG
1761 AGCAGCCCCAGAGGCTCTCTGTCTGCCTGCCGGTAGGTGTTCCCACCTGACACACTCTCTGGGACAGGATGGAGCCATAG
1841 GCCCTCCTCTGGCTTGGCTGTGAGTCGGGAGGATGCCTACCGGGAAGTATGTGTGACATGACCTGAAATCCCCCGACAGG
1921 TCACCTGGGAGAGGCCGGGAGAGGGCAAGCGCCACACCTGCCAGGTGGCCCAGCTCAGCCCACCTGCCCCCACCCCAGAG
2001 CTACCTGCAGTGGGTGGTCAGGGTGGGGTGTCCCCACACCCTCTTCCCTACCCACCCCTTGGGCCTGGGTACCAGCTGCT
2081 CCCACAGACCCACTGAGCACATGCGTCTCCACTAGATGGTTGCCCGTGATGAACGGAGCTCACTGGCCATGACCCCACAG
2161 GCCCAGCTGCACACCCAGGTCATGAGCACGGCCCTGCCCCACCCCCATAGGGGCCCTCTGACCCCTCCACTCACTCATCC
2241 GCCACCAAAGCTGTGGAGGCCTGTGGCAGGGTCTCAGTCACCTCCATCCCCTGTGCCCGGAACCAAGCCCGGAACACAGG
2321 AGGTGCTCTGCAAGTGCTCGTGGGGAGTGGCTGCCTTGGGGTCTAAAGGCAGAGAGGCAGGAGGAGCAAGGGACGGGCCC
2401 ACTGGTGCTGACGGCAGCACCACCATTCAGCACTGAGACTGAGGCTTAAGGAGTCCATCCAAATGACTCCATAGCCGCCG
2481 CGTTCAGGCTGGAAAAGGCTTTTCAGCGGAGGGTGCTGTAACTGTCCAGCTGTGGGAGAGGAGATACCAGCCCAGGAGAA
2561 GAGCAGCTGGCCCTACTGGGCCTAGAAGTTTGGGAGACCCATCCCAGCAAGGATGGGAAATCAAGACAGATGTTGAGCAT
2641 GGATTTCCCAGAGGTGGTGACTGCGCCGCACAGAGGAGCATCTCTGCCTGGGAGGAGGGAGAGGGCTCCCGCCGGGCTGC
2721 CAGAGCCGAGCAAGTACCTGCACCTTCAGCCAGACACATGCTGGGCATTCTTCAGATGCCATCGTAAGGCGGAGGCCTGG
2801 GACGTCCCAGAACACCTATGGATGCTGCCCCTCGGGCTTTCTCGGCCACACCAGATGCAGAGGGGCTGTGGGAGCCTGGA
2881 AAAGGGCTTGGTGGTCCAGCTGCTTTGTTGTTGTTGTTTTTGTTTTGTTTGTTTGTTTGTTTGTTTGTTTTGGCTTGGGG
2961 CTTTTCTTAGAAGTGATGTGTTGTTAGAAACTTCAAACCAGATACAAATATACCCAACGAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaGUUCCAG--GC-GACACUUGUGc 5'
            |:||| |   | | |||||||| 
Target 5' agCGAGGGCAAAGACGGTGAACACa 3'
 805 - 829 154.00 -18.10
2 
miRNA  3' uaGUUCCAGGCGACACUUGUGc 5'
            | |||||     |||:||| 
Target 5' acCCAGGTC----ATGAGCACg 3'
 2173 - 2190 134.00 -16.90
3 
miRNA  3' uaGU-UCCAGGCGACACUUGUGc 5'
            || ||  || |  |||:||| 
Target 5' ccCACAGACCCAC--TGAGCACa 3'
 2081 - 2101 132.00 -9.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30130458 21 COSMIC
COSN30111913 23 COSMIC
COSN28800981 32 COSMIC
COSN26731037 53 COSMIC
COSN18718363 58 COSMIC
COSN1300906 199 COSMIC
COSN5156296 332 COSMIC
COSN1300904 361 COSMIC
COSN15381900 414 COSMIC
COSN20099799 456 COSMIC
COSN7504770 473 COSMIC
COSN23213727 620 COSMIC
COSN5865310 964 COSMIC
COSN15668333 1376 COSMIC
COSN15120507 1497 COSMIC
COSN17450332 1513 COSMIC
COSN25491942 1652 COSMIC
COSN24294889 1735 COSMIC
COSN25645178 1792 COSMIC
COSN15662937 1922 COSMIC
COSN32105066 1922 COSMIC
COSN18797251 1991 COSMIC
COSN9240855 2075 COSMIC
COSN14893249 2167 COSMIC
COSN5063706 2199 COSMIC
COSN29617414 2220 COSMIC
COSN20660302 2543 COSMIC
COSN21088013 2625 COSMIC
COSN22012296 2720 COSMIC
COSN20099795 2924 COSMIC
rs10023470 585 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs893474870 1 dbSNP
rs1325985585 2 dbSNP
rs545052742 3 dbSNP
rs1380689274 9 dbSNP
rs760649460 15 dbSNP
rs931101091 19 dbSNP
rs1384011789 21 dbSNP
rs377581924 24 dbSNP
rs866509461 25 dbSNP
rs921090710 27 dbSNP
rs11721763 28 dbSNP
rs78599329 31 dbSNP
rs59409649 32 dbSNP
rs1175710070 33 dbSNP
rs775671977 34 dbSNP
rs1469755990 44 dbSNP
rs987463080 45 dbSNP
rs78445843 48 dbSNP
rs183139546 50 dbSNP
rs4318651 53 dbSNP
rs35116829 60 dbSNP
rs952653133 62 dbSNP
rs1415294315 64 dbSNP
rs566624975 68 dbSNP
rs968894660 71 dbSNP
rs1460577303 74 dbSNP
rs915897871 80 dbSNP
rs1023067931 85 dbSNP
rs147175966 88 dbSNP
rs991422283 89 dbSNP
rs1317490423 90 dbSNP
rs1013614219 99 dbSNP
rs1206435213 103 dbSNP
rs539506664 112 dbSNP
rs1432554651 114 dbSNP
rs190241190 115 dbSNP
rs1282208505 117 dbSNP
rs561774379 119 dbSNP
rs540184948 120 dbSNP
rs1278905489 122 dbSNP
rs1057219140 133 dbSNP
rs1003843317 135 dbSNP
rs1300048451 141 dbSNP
rs1231529367 142 dbSNP
rs186517170 145 dbSNP
rs866397682 148 dbSNP
rs1332443185 149 dbSNP
rs886867254 150 dbSNP
rs528093153 151 dbSNP
rs1375208440 159 dbSNP
rs1447946599 161 dbSNP
rs1195848700 169 dbSNP
rs931048792 171 dbSNP
rs921123057 172 dbSNP
rs1188171154 174 dbSNP
rs1039547209 177 dbSNP
rs1428930590 178 dbSNP
rs1157933797 181 dbSNP
rs568088203 190 dbSNP
rs1430258971 193 dbSNP
rs1374850054 194 dbSNP
rs114025050 205 dbSNP
rs1011814478 206 dbSNP
rs889342285 208 dbSNP
rs1414431388 210 dbSNP
rs1294083601 212 dbSNP
rs527980462 213 dbSNP
rs987881110 214 dbSNP
rs560283433 218 dbSNP
rs1181305415 224 dbSNP
rs1207376007 225 dbSNP
rs551571989 230 dbSNP
rs1485520609 231 dbSNP
rs376324046 233 dbSNP
rs978837221 234 dbSNP
rs1040789254 235 dbSNP
rs1363851352 237 dbSNP
rs968760350 244 dbSNP
rs756647155 248 dbSNP
rs1171639407 249 dbSNP
rs1208059155 250 dbSNP
rs533605750 254 dbSNP
rs562816477 256 dbSNP
rs1389863462 257 dbSNP
rs7439798 261 dbSNP
rs878972328 268 dbSNP
rs781353813 270 dbSNP
rs573914149 276 dbSNP
rs562069194 278 dbSNP
rs755376561 281 dbSNP
rs1314771877 286 dbSNP
rs540507153 287 dbSNP
rs1004864823 288 dbSNP
rs931162614 293 dbSNP
rs1194846355 295 dbSNP
rs573191781 297 dbSNP
rs1438997035 303 dbSNP
rs1191685870 307 dbSNP
rs143502297 314 dbSNP
rs539235359 315 dbSNP
rs1394337222 320 dbSNP
rs1454655795 322 dbSNP
rs915807753 323 dbSNP
rs1371095180 325 dbSNP
rs180721983 335 dbSNP
rs1297771921 347 dbSNP
rs1397317756 351 dbSNP
rs995287174 352 dbSNP
rs556771523 353 dbSNP
rs899557327 356 dbSNP
rs1039963167 361 dbSNP
rs928661781 368 dbSNP
rs1306138262 370 dbSNP
rs115136197 372 dbSNP
rs890945125 379 dbSNP
rs148422088 380 dbSNP
rs1340870612 381 dbSNP
rs935225385 382 dbSNP
rs967891816 383 dbSNP
rs553453784 384 dbSNP
rs990292562 386 dbSNP
rs189186171 388 dbSNP
rs534186864 389 dbSNP
rs997801381 393 dbSNP
rs1170010784 396 dbSNP
rs1160349660 397 dbSNP
rs1475108843 399 dbSNP
rs900833354 402 dbSNP
rs947492956 404 dbSNP
rs1416186921 405 dbSNP
rs1462458393 407 dbSNP
rs1190637916 409 dbSNP
rs915956586 414 dbSNP
rs992073800 415 dbSNP
rs1003951412 417 dbSNP
rs1296740220 426 dbSNP
rs1342055674 430 dbSNP
rs10014338 434 dbSNP
rs1272019768 441 dbSNP
rs187263618 447 dbSNP
rs1215499489 451 dbSNP
rs983078882 454 dbSNP
rs951596948 456 dbSNP
rs386399177 457 dbSNP
rs575921833 457 dbSNP
rs1228741787 458 dbSNP
rs1333826542 459 dbSNP
rs1055632395 461 dbSNP
rs1461980218 462 dbSNP
rs386399176 462 dbSNP
rs77691359 462 dbSNP
rs995149529 467 dbSNP
rs899588478 477 dbSNP
rs563108370 478 dbSNP
rs762721840 481 dbSNP
rs1340997852 483 dbSNP
rs550752770 487 dbSNP
rs1008388088 488 dbSNP
rs1317718961 507 dbSNP
rs1292225680 509 dbSNP
rs1355544059 511 dbSNP
rs890983022 512 dbSNP
rs1052683254 514 dbSNP
rs977855129 515 dbSNP
rs1216371510 516 dbSNP
rs1287936846 522 dbSNP
rs935261404 524 dbSNP
rs1209016728 525 dbSNP
rs1321419494 527 dbSNP
rs914601217 528 dbSNP
rs903756685 541 dbSNP
rs1405862127 544 dbSNP
rs953518157 545 dbSNP
rs1043039807 548 dbSNP
rs1382566099 559 dbSNP
rs1392666280 560 dbSNP
rs529413727 562 dbSNP
rs947355553 563 dbSNP
rs966721620 564 dbSNP
rs1295986062 566 dbSNP
rs1373072017 568 dbSNP
rs1371934324 571 dbSNP
rs1224294904 573 dbSNP
rs10023470 585 dbSNP
rs1426264860 586 dbSNP
rs1280770097 588 dbSNP
rs1004264355 589 dbSNP
rs886782657 594 dbSNP
rs540617146 595 dbSNP
rs1026660230 601 dbSNP
rs1208908105 604 dbSNP
rs775500606 613 dbSNP
rs995253562 618 dbSNP
rs1270964753 620 dbSNP
rs1173458447 621 dbSNP
rs1453101965 621 dbSNP
rs369263860 625 dbSNP
rs114620595 626 dbSNP
rs371579178 626 dbSNP
rs144794720 627 dbSNP
rs201230051 627 dbSNP
rs557121211 628 dbSNP
rs914612435 628 dbSNP
rs72355702 629 dbSNP
rs990230491 629 dbSNP
rs535173166 631 dbSNP
rs1356946282 638 dbSNP
rs1479171751 640 dbSNP
rs1027202651 644 dbSNP
rs1269575376 646 dbSNP
rs1184418841 648 dbSNP
rs973743353 651 dbSNP
rs1410175898 654 dbSNP
rs963744392 656 dbSNP
rs1391618763 661 dbSNP
rs1460874150 663 dbSNP
rs1326423072 665 dbSNP
rs1332626400 667 dbSNP
rs531101006 674 dbSNP
rs1269375338 676 dbSNP
rs553074099 679 dbSNP
rs966253965 680 dbSNP
rs749552204 686 dbSNP
rs1213620725 688 dbSNP
rs908082287 693 dbSNP
rs1291145344 694 dbSNP
rs1453818648 695 dbSNP
rs1191567020 696 dbSNP
rs1241857746 710 dbSNP
rs890838622 713 dbSNP
rs114948233 717 dbSNP
rs1415032476 721 dbSNP
rs879919695 722 dbSNP
rs999276031 724 dbSNP
rs554159392 726 dbSNP
rs1474563782 733 dbSNP
rs1164996492 735 dbSNP
rs149393116 736 dbSNP
rs1043658289 748 dbSNP
rs1317439492 755 dbSNP
rs1345516918 760 dbSNP
rs534294548 761 dbSNP
rs865809573 768 dbSNP
rs367631628 770 dbSNP
rs558939582 771 dbSNP
rs1359124266 776 dbSNP
rs1396371870 777 dbSNP
rs928689723 783 dbSNP
rs60545072 784 dbSNP
rs1485139823 786 dbSNP
rs1463995661 792 dbSNP
rs1042018139 793 dbSNP
rs1157888797 798 dbSNP
rs930096342 803 dbSNP
rs781720843 807 dbSNP
rs974344222 808 dbSNP
rs1334984614 812 dbSNP
rs1342288983 815 dbSNP
rs893105959 818 dbSNP
rs569326387 819 dbSNP
rs551171931 820 dbSNP
rs921986219 821 dbSNP
rs1200705910 823 dbSNP
rs1278595791 825 dbSNP
rs910899873 827 dbSNP
rs529498604 830 dbSNP
rs1200630205 835 dbSNP
rs1257697898 836 dbSNP
rs1435500605 837 dbSNP
rs57186692 839 dbSNP
rs547162839 847 dbSNP
rs955152642 848 dbSNP
rs1272052078 853 dbSNP
rs1031132546 859 dbSNP
rs1238775981 864 dbSNP
rs999222305 871 dbSNP
rs967894540 874 dbSNP
rs1394225683 880 dbSNP
rs1022067350 881 dbSNP
rs1465748118 885 dbSNP
rs1173332498 886 dbSNP
rs1012147831 888 dbSNP
rs895026809 896 dbSNP
rs1389810996 897 dbSNP
rs944838296 908 dbSNP
rs747379587 915 dbSNP
rs1449628672 916 dbSNP
rs138981228 919 dbSNP
rs1347563629 921 dbSNP
rs984108948 922 dbSNP
rs907293945 930 dbSNP
rs1257336159 932 dbSNP
rs1047213945 934 dbSNP
rs930024362 935 dbSNP
rs1233740101 938 dbSNP
rs1369026981 939 dbSNP
rs920118755 942 dbSNP
rs181923378 943 dbSNP
rs756866720 947 dbSNP
rs919580522 948 dbSNP
rs1327280296 949 dbSNP
rs1412151669 958 dbSNP
rs1371790808 964 dbSNP
rs1379661409 967 dbSNP
rs1460632125 971 dbSNP
rs1170127656 973 dbSNP
rs73796584 978 dbSNP
rs986490874 983 dbSNP
rs569176151 990 dbSNP
rs1422582392 992 dbSNP
rs1173919808 997 dbSNP
rs1478159024 998 dbSNP
rs1387765585 1005 dbSNP
rs923627890 1011 dbSNP
rs1324361159 1013 dbSNP
rs775951241 1014 dbSNP
rs1232027125 1015 dbSNP
rs1278299881 1019 dbSNP
rs530853986 1020 dbSNP
rs1211741786 1021 dbSNP
rs971634762 1023 dbSNP
rs10033032 1024 dbSNP
rs1252508763 1028 dbSNP
rs1022098259 1029 dbSNP
rs1259374829 1030 dbSNP
rs1012011997 1031 dbSNP
rs1426987985 1033 dbSNP
rs1193168261 1035 dbSNP
rs752203403 1039 dbSNP
rs1345759777 1042 dbSNP
rs1424436802 1044 dbSNP
rs1280858697 1046 dbSNP
rs1219980461 1047 dbSNP
rs1010553709 1050 dbSNP
rs1458838225 1055 dbSNP
rs541990448 1060 dbSNP
rs74685582 1061 dbSNP
rs1399044353 1067 dbSNP
rs373497840 1067 dbSNP
rs77810263 1068 dbSNP
rs773855696 1070 dbSNP
rs1025636462 1075 dbSNP
rs762039794 1079 dbSNP
rs1311353359 1080 dbSNP
rs1322311025 1086 dbSNP
rs1356875881 1088 dbSNP
rs546731998 1090 dbSNP
rs576384934 1091 dbSNP
rs944848626 1094 dbSNP
rs898555598 1099 dbSNP
rs908017994 1100 dbSNP
rs1414675898 1110 dbSNP
rs566916334 1113 dbSNP
rs942828817 1117 dbSNP
rs189463650 1128 dbSNP
rs1473471965 1134 dbSNP
rs1051820974 1135 dbSNP
rs934243142 1143 dbSNP
rs1424923260 1144 dbSNP
rs1167475815 1145 dbSNP
rs1362425293 1146 dbSNP
rs1412473697 1149 dbSNP
rs539712941 1150 dbSNP
rs1187071311 1151 dbSNP
rs1362114471 1154 dbSNP
rs923639042 1155 dbSNP
rs1482245722 1159 dbSNP
rs1412520861 1161 dbSNP
rs1301781386 1172 dbSNP
rs114499525 1175 dbSNP
rs946488122 1176 dbSNP
rs1352882784 1178 dbSNP
rs61318481 1178 dbSNP
rs536053578 1179 dbSNP
rs990678316 1181 dbSNP
rs1483579088 1182 dbSNP
rs1184121112 1183 dbSNP
rs11463561 1184 dbSNP
rs376327175 1184 dbSNP
rs545348382 1184 dbSNP
rs59286727 1184 dbSNP
rs746881491 1184 dbSNP
rs1491238477 1185 dbSNP
rs201534485 1187 dbSNP
rs75278193 1190 dbSNP
rs528599044 1194 dbSNP
rs1449659386 1195 dbSNP
rs1295942825 1199 dbSNP
rs570829093 1200 dbSNP
rs982464976 1204 dbSNP
rs1032896114 1206 dbSNP
rs996129865 1207 dbSNP
rs552555635 1212 dbSNP
rs950633304 1217 dbSNP
rs530842131 1219 dbSNP
rs900501226 1221 dbSNP
rs1278106989 1229 dbSNP
rs1018971031 1230 dbSNP
rs1231925494 1231 dbSNP
rs1025666226 1232 dbSNP
rs1382047668 1233 dbSNP
rs563575576 1235 dbSNP
rs1009386057 1237 dbSNP
rs1240421043 1239 dbSNP
rs769672469 1239 dbSNP
rs1452901918 1240 dbSNP
rs1190967413 1241 dbSNP
rs886499639 1246 dbSNP
rs1415791711 1251 dbSNP
rs994127386 1253 dbSNP
rs35810548 1256 dbSNP
rs1466105892 1257 dbSNP
rs930775510 1260 dbSNP
rs898589621 1261 dbSNP
rs1318071135 1262 dbSNP
rs1392030629 1263 dbSNP
rs899373323 1266 dbSNP
rs1055299452 1268 dbSNP
rs184315883 1274 dbSNP
rs529826882 1285 dbSNP
rs889974968 1289 dbSNP
rs563450839 1304 dbSNP
rs181666583 1315 dbSNP
rs6836478 1316 dbSNP
rs1221348686 1317 dbSNP
rs1475150295 1322 dbSNP
rs1384270413 1326 dbSNP
rs1422294773 1327 dbSNP
rs184781789 1333 dbSNP
rs774821580 1335 dbSNP
rs1323995242 1339 dbSNP
rs192605214 1346 dbSNP
rs946352563 1347 dbSNP
rs974640363 1350 dbSNP
rs1438888567 1352 dbSNP
rs56879054 1352 dbSNP
rs1340107359 1354 dbSNP
rs557623802 1359 dbSNP
rs1272940725 1362 dbSNP
rs1280140213 1363 dbSNP
rs1354925479 1370 dbSNP
rs1212272006 1374 dbSNP
rs747506477 1376 dbSNP
rs1314112323 1378 dbSNP
rs1214529239 1382 dbSNP
rs1262088469 1384 dbSNP
rs1488408376 1387 dbSNP
rs1019295166 1392 dbSNP
rs1008878259 1394 dbSNP
rs1163707753 1398 dbSNP
rs563903674 1400 dbSNP
rs1415714958 1403 dbSNP
rs1398796156 1407 dbSNP
rs536166205 1410 dbSNP
rs981941129 1412 dbSNP
rs1360178852 1413 dbSNP
rs1400814433 1414 dbSNP
rs780352023 1422 dbSNP
rs545830559 1423 dbSNP
rs1260863508 1429 dbSNP
rs568622444 1433 dbSNP
rs1486835979 1439 dbSNP
rs138193008 1440 dbSNP
rs1253472471 1445 dbSNP
rs1441281936 1446 dbSNP
rs1351517508 1449 dbSNP
rs962742020 1450 dbSNP
rs570907613 1451 dbSNP
rs1007415323 1453 dbSNP
rs1047087282 1459 dbSNP
rs949711480 1469 dbSNP
rs1160444291 1478 dbSNP
rs1190674451 1479 dbSNP
rs10011121 1481 dbSNP
rs1334293196 1484 dbSNP
rs1342820224 1494 dbSNP
rs781252754 1494 dbSNP
rs935759905 1495 dbSNP
rs1030262967 1497 dbSNP
rs974547320 1507 dbSNP
rs998326762 1509 dbSNP
rs777388713 1513 dbSNP
rs1253941900 1514 dbSNP
rs964560627 1514 dbSNP
rs1042654382 1520 dbSNP
rs80040143 1521 dbSNP
rs893498363 1523 dbSNP
rs752218259 1524 dbSNP
rs987802975 1528 dbSNP
rs1054767406 1531 dbSNP
rs1294073504 1546 dbSNP
rs569989256 1549 dbSNP
rs927694679 1550 dbSNP
rs1271859304 1551 dbSNP
rs541992217 1552 dbSNP
rs1441255307 1553 dbSNP
rs1196463183 1555 dbSNP
rs1376201219 1562 dbSNP
rs529962182 1565 dbSNP
rs1477802394 1567 dbSNP
rs1173281367 1573 dbSNP
rs1342409084 1581 dbSNP
rs1034853769 1582 dbSNP
rs1408325422 1585 dbSNP
rs1464526202 1591 dbSNP
rs994867028 1592 dbSNP
rs559090679 1594 dbSNP
rs111611382 1598 dbSNP
rs1033743460 1599 dbSNP
rs973341154 1603 dbSNP
rs963277610 1605 dbSNP
rs1293910517 1607 dbSNP
rs1315448778 1608 dbSNP
rs532203596 1614 dbSNP
rs1046634339 1615 dbSNP
rs116656999 1616 dbSNP
rs954273690 1619 dbSNP
rs543194313 1620 dbSNP
rs1170539732 1636 dbSNP
rs1207878802 1638 dbSNP
rs1451272245 1639 dbSNP
rs754895101 1640 dbSNP
rs998218545 1642 dbSNP
rs553186741 1652 dbSNP
rs140505294 1653 dbSNP
rs1435138110 1654 dbSNP
rs1011143864 1655 dbSNP
rs560723911 1657 dbSNP
rs1463960764 1669 dbSNP
rs1292170804 1675 dbSNP
rs1268408487 1696 dbSNP
rs894035688 1697 dbSNP
rs1386994973 1700 dbSNP
rs1055199862 1701 dbSNP
rs1001841890 1704 dbSNP
rs1304517821 1705 dbSNP
rs35318877 1705 dbSNP
rs1278239643 1708 dbSNP
rs906182305 1711 dbSNP
rs551413835 1720 dbSNP
rs1482355406 1729 dbSNP
rs1046184802 1732 dbSNP
rs929020890 1734 dbSNP
rs1206644779 1736 dbSNP
rs1211402390 1737 dbSNP
rs1342203881 1738 dbSNP
rs780051186 1744 dbSNP
rs919121453 1746 dbSNP
rs1038806666 1751 dbSNP
rs1230543081 1752 dbSNP
rs1263935971 1754 dbSNP
rs943184803 1756 dbSNP
rs1163212113 1758 dbSNP
rs541146358 1760 dbSNP
rs1301704826 1762 dbSNP
rs1037510654 1767 dbSNP
rs911749478 1769 dbSNP
rs1165856447 1781 dbSNP
rs1358276785 1781 dbSNP
rs73796583 1782 dbSNP
rs1298296106 1784 dbSNP
rs1348520475 1786 dbSNP
rs910432313 1786 dbSNP
rs985873691 1788 dbSNP
rs954107724 1791 dbSNP
rs1247956771 1792 dbSNP
rs922593839 1796 dbSNP
rs1286835303 1799 dbSNP
rs976830843 1806 dbSNP
rs1486855319 1810 dbSNP
rs1410378818 1813 dbSNP
rs919186749 1815 dbSNP
rs1424874405 1816 dbSNP
rs1374861547 1819 dbSNP
rs966754335 1828 dbSNP
rs533201183 1832 dbSNP
rs1158801756 1840 dbSNP
rs1467774601 1847 dbSNP
rs1346585704 1850 dbSNP
rs989566488 1852 dbSNP
rs1464166801 1856 dbSNP
rs10030127 1858 dbSNP
rs1158811456 1860 dbSNP
rs1033968270 1861 dbSNP
rs1306848486 1862 dbSNP
rs1375790424 1863 dbSNP
rs765536489 1866 dbSNP
rs1002277369 1873 dbSNP
rs73796582 1874 dbSNP
rs34241247 1881 dbSNP
rs558997160 1882 dbSNP
rs537155988 1883 dbSNP
rs368705001 1891 dbSNP
rs1236732437 1895 dbSNP
rs1256266298 1910 dbSNP
rs1032616147 1911 dbSNP
rs897554798 1912 dbSNP
rs148313774 1915 dbSNP
rs904198618 1919 dbSNP
rs548196545 1921 dbSNP
rs941810794 1931 dbSNP
rs888940633 1936 dbSNP
rs1050406925 1937 dbSNP
rs1339869047 1941 dbSNP
rs933216906 1944 dbSNP
rs74563302 1950 dbSNP
rs929171207 1951 dbSNP
rs1300712235 1953 dbSNP
rs976694842 1957 dbSNP
rs1403146416 1958 dbSNP
rs1225897824 1960 dbSNP
rs1256788734 1965 dbSNP
rs1457689171 1973 dbSNP
rs1288473748 1980 dbSNP
rs1205728013 1987 dbSNP
rs945464442 1989 dbSNP
rs761173405 1990 dbSNP
rs1391219478 1993 dbSNP
rs989514498 1995 dbSNP
rs958268644 2000 dbSNP
rs1160374328 2001 dbSNP
rs1475158938 2002 dbSNP
rs1190207381 2004 dbSNP
rs1425280696 2013 dbSNP
rs1034243829 2015 dbSNP
rs973301750 2016 dbSNP
rs1367285292 2018 dbSNP
rs1422875776 2023 dbSNP
rs775968172 2025 dbSNP
rs1330658752 2026 dbSNP
rs942027657 2027 dbSNP
rs1434584929 2029 dbSNP
rs1293100387 2030 dbSNP
rs971358418 2037 dbSNP
rs1024664152 2042 dbSNP
rs926663763 2054 dbSNP
rs1424999568 2055 dbSNP
rs1215631473 2061 dbSNP
rs993125205 2063 dbSNP
rs114751442 2064 dbSNP
rs971250135 2065 dbSNP
rs1463269227 2067 dbSNP
rs547335960 2077 dbSNP
rs1016055887 2090 dbSNP
rs956898987 2093 dbSNP
rs1169508446 2095 dbSNP
rs1263655930 2098 dbSNP
rs1006382287 2104 dbSNP
rs1032563859 2105 dbSNP
rs746206317 2111 dbSNP
rs373296520 2115 dbSNP
rs1433085322 2117 dbSNP
rs1050675241 2123 dbSNP
rs1339854630 2124 dbSNP
rs112777354 2125 dbSNP
rs1405182673 2126 dbSNP
rs559312054 2126 dbSNP
rs1017308216 2132 dbSNP
rs1389062036 2134 dbSNP
rs779288867 2135 dbSNP
rs1458875454 2136 dbSNP
rs564943121 2137 dbSNP
rs549801851 2139 dbSNP
rs1447266366 2149 dbSNP
rs1194678125 2156 dbSNP
rs890175889 2161 dbSNP
rs1051522438 2166 dbSNP
rs76781555 2167 dbSNP
rs897696490 2170 dbSNP
rs945412035 2174 dbSNP
rs1360121533 2176 dbSNP
rs560904488 2178 dbSNP
rs568245166 2181 dbSNP
rs989546862 2184 dbSNP
rs936737944 2189 dbSNP
rs747778076 2190 dbSNP
rs780695031 2196 dbSNP
rs981151773 2202 dbSNP
rs546843912 2204 dbSNP
rs1356972263 2207 dbSNP
rs1274008849 2208 dbSNP
rs1237525090 2211 dbSNP
rs949432286 2218 dbSNP
rs981324733 2224 dbSNP
rs542628896 2240 dbSNP
rs572098688 2241 dbSNP
rs1298554553 2250 dbSNP
rs528170117 2251 dbSNP
rs187639281 2255 dbSNP
rs1329652237 2256 dbSNP
rs988254025 2264 dbSNP
rs1437659481 2273 dbSNP
rs972302314 2287 dbSNP
rs961747543 2289 dbSNP
rs956852522 2294 dbSNP
rs1015920236 2295 dbSNP
rs143551232 2296 dbSNP
rs575319026 2297 dbSNP
rs979666506 2298 dbSNP
rs751182697 2299 dbSNP
rs1408923286 2304 dbSNP
rs1445114929 2305 dbSNP
rs1331058632 2306 dbSNP
rs577325686 2310 dbSNP
rs918657699 2316 dbSNP
rs1168790388 2317 dbSNP
rs1343599190 2326 dbSNP
rs1028847205 2336 dbSNP
rs1265006302 2337 dbSNP
rs954409823 2339 dbSNP
rs1030486902 2340 dbSNP
rs997722325 2343 dbSNP
rs1375657433 2345 dbSNP
rs1438635008 2347 dbSNP
rs1184162986 2350 dbSNP
rs901674844 2353 dbSNP
rs558886566 2354 dbSNP
rs375086275 2357 dbSNP
rs752391523 2358 dbSNP
rs897644154 2359 dbSNP
rs537520700 2360 dbSNP
rs1010088222 2361 dbSNP
rs1464478602 2371 dbSNP
rs576445738 2372 dbSNP
rs905095008 2373 dbSNP
rs1397576781 2376 dbSNP
rs1392787849 2384 dbSNP
rs1484048135 2394 dbSNP
rs758460110 2395 dbSNP
rs554674514 2398 dbSNP
rs1405074478 2401 dbSNP
rs148876606 2404 dbSNP
rs765099851 2408 dbSNP
rs1276957028 2412 dbSNP
rs750215418 2413 dbSNP
rs1251672935 2423 dbSNP
rs1341136901 2424 dbSNP
rs926660075 2426 dbSNP
rs754526123 2430 dbSNP
rs917961018 2431 dbSNP
rs58274198 2441 dbSNP
rs1200289935 2452 dbSNP
rs1271093999 2453 dbSNP
rs6849590 2464 dbSNP
rs1170291793 2465 dbSNP
rs1328953769 2467 dbSNP
rs918088230 2470 dbSNP
rs1413550639 2472 dbSNP
rs145670181 2476 dbSNP
rs979571677 2477 dbSNP
rs1337675941 2479 dbSNP
rs12644312 2480 dbSNP
rs1296281671 2481 dbSNP
rs144502367 2482 dbSNP
rs1242390141 2488 dbSNP
rs987104704 2499 dbSNP
rs984842300 2505 dbSNP
rs6822927 2507 dbSNP
rs1029191399 2508 dbSNP
rs201833356 2514 dbSNP
rs1263099618 2531 dbSNP
rs1209577513 2535 dbSNP
rs997270972 2536 dbSNP
rs567346994 2538 dbSNP
rs993195660 2539 dbSNP
rs961741922 2540 dbSNP
rs58448418 2546 dbSNP
rs760064993 2547 dbSNP
rs1358214282 2553 dbSNP
rs1328858492 2555 dbSNP
rs905035592 2556 dbSNP
rs184610936 2561 dbSNP
rs1394165576 2562 dbSNP
rs1314114970 2563 dbSNP
rs560197725 2564 dbSNP
rs1230705202 2572 dbSNP
rs1013544586 2575 dbSNP
rs1279621860 2576 dbSNP
rs1215222290 2578 dbSNP
rs202098694 2581 dbSNP
rs1053793948 2585 dbSNP
rs1242930451 2587 dbSNP
rs1445675225 2588 dbSNP
rs1001240274 2592 dbSNP
rs1335725473 2608 dbSNP
rs1159223357 2617 dbSNP
rs1470006677 2623 dbSNP
rs1387549262 2627 dbSNP
rs1464496907 2632 dbSNP
rs905185987 2633 dbSNP
rs192444462 2634 dbSNP
rs1329024323 2635 dbSNP
rs949431369 2637 dbSNP
rs6854437 2639 dbSNP
rs1043839517 2640 dbSNP
rs1408687886 2645 dbSNP
rs62277598 2656 dbSNP
rs1221745309 2659 dbSNP
rs188084890 2664 dbSNP
rs909417709 2665 dbSNP
rs1236677696 2667 dbSNP
rs987439800 2668 dbSNP
rs1252217420 2675 dbSNP
rs1431018645 2676 dbSNP
rs1175048386 2678 dbSNP
rs1429969444 2679 dbSNP
rs985050003 2680 dbSNP
rs1168315207 2682 dbSNP
rs1353640715 2683 dbSNP
rs1441764775 2687 dbSNP
rs554635588 2692 dbSNP
rs1403224404 2694 dbSNP
rs542721538 2695 dbSNP
rs921594771 2696 dbSNP
rs1324906765 2698 dbSNP
rs976263912 2700 dbSNP
rs1271343057 2701 dbSNP
rs965737583 2703 dbSNP
rs1020092293 2705 dbSNP
rs961691488 2710 dbSNP
rs1211034704 2711 dbSNP
rs1330404296 2713 dbSNP
rs572063757 2714 dbSNP
rs957292344 2716 dbSNP
rs35845946 2725 dbSNP
rs1001457003 2727 dbSNP
rs200565117 2728 dbSNP
rs905216469 2728 dbSNP
rs1356544140 2732 dbSNP
rs1422919582 2732 dbSNP
rs1285453018 2733 dbSNP
rs1302665068 2734 dbSNP
rs1452905493 2735 dbSNP
rs749682359 2737 dbSNP
rs1030924547 2745 dbSNP
rs374219079 2751 dbSNP
rs1013691436 2757 dbSNP
rs896550631 2763 dbSNP
rs1361834435 2765 dbSNP
rs1318267117 2776 dbSNP
rs1275498484 2777 dbSNP
rs1458652046 2782 dbSNP
rs141989889 2783 dbSNP
rs183016446 2784 dbSNP
rs1403552525 2789 dbSNP
rs889937497 2790 dbSNP
rs887947523 2791 dbSNP
rs1188068888 2801 dbSNP
rs537640456 2803 dbSNP
rs567506419 2804 dbSNP
rs116057399 2805 dbSNP
rs1366423621 2816 dbSNP
rs4302467 2819 dbSNP
rs975696750 2820 dbSNP
rs770049016 2821 dbSNP
rs972967690 2823 dbSNP
rs944461395 2825 dbSNP
rs1272298316 2828 dbSNP
rs745914583 2833 dbSNP
rs1244330576 2834 dbSNP
rs912949125 2841 dbSNP
rs940355993 2843 dbSNP
rs116219527 2844 dbSNP
rs957240992 2845 dbSNP
rs1393045439 2851 dbSNP
rs6822277 2852 dbSNP
rs6854053 2853 dbSNP
rs386671219 2854 dbSNP
rs71645800 2854 dbSNP
rs879769745 2854 dbSNP
rs991965399 2854 dbSNP
rs1291382085 2865 dbSNP
rs1460758741 2874 dbSNP
rs1183937999 2880 dbSNP
rs1386151041 2880 dbSNP
rs1473871247 2884 dbSNP
rs1156933348 2890 dbSNP
rs1246133976 2891 dbSNP
rs1340980668 2892 dbSNP
rs370221864 2899 dbSNP
rs375639354 2901 dbSNP
rs34264596 2903 dbSNP
rs1013555683 2917 dbSNP
rs531751147 2918 dbSNP
rs111836142 2919 dbSNP
rs542684679 2923 dbSNP
rs143897039 2926 dbSNP
rs144002554 2927 dbSNP
rs1201141531 2930 dbSNP
rs1434211226 2930 dbSNP
rs1351605442 2931 dbSNP
rs199590413 2931 dbSNP
rs779276786 2931 dbSNP
rs1278449904 2932 dbSNP
rs1303814941 2932 dbSNP
rs1004950385 2935 dbSNP
rs1022333632 2943 dbSNP
rs1224962253 2944 dbSNP
rs1261224307 2945 dbSNP
rs1322705515 2949 dbSNP
rs1179854832 2951 dbSNP
rs142492697 2951 dbSNP
rs143322575 2951 dbSNP
rs1436182710 2951 dbSNP
rs754404769 2951 dbSNP
rs776292506 2951 dbSNP
rs1429237017 2952 dbSNP
rs887970750 2956 dbSNP
rs188088637 2964 dbSNP
rs1170654297 2967 dbSNP
rs183095824 2970 dbSNP
rs76001139 2971 dbSNP
rs778501749 2977 dbSNP
rs934141895 2983 dbSNP
rs578006113 2987 dbSNP
rs1404713363 3003 dbSNP
rs754801390 3004 dbSNP
rs1389334476 3008 dbSNP
rs944410369 3010 dbSNP
rs1327837094 3011 dbSNP
rs116402477 3018 dbSNP
rs1335950657 3018 dbSNP
rs1052825468 3019 dbSNP
rs935752733 3024 dbSNP
rs147568453 3029 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 768239.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000319098.4 | 3UTR | AGGCACACUGGGCCUGAGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.669 6.2e-3 -0.489 4.5e-2 13 Click to see details
GSE32688 Pancreatic cancer -0.209 1.3e-1 0.006 4.9e-1 32 Click to see details
GSE42095 Differentiated embryonic stem cells -0.127 2.8e-1 -0.220 1.6e-1 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.112 3.0e-1 -0.095 3.3e-1 25 Click to see details
GSE19350 CNS germ cell tumors 0.158 3.1e-1 0.133 3.4e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.042 4.3e-1 0.189 2.1e-1 20 Click to see details
GSE21687 Ependynoma primary tumors -0.011 4.7e-1 -0.255 2.1e-2 64 Click to see details
GSE28544 Breast cancer 0.016 4.7e-1 0.188 1.9e-1 24 Click to see details
GSE28544 Breast cancer 0.016 4.7e-1 0.188 1.9e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
0.016 4.7e-1 0.188 1.9e-1 24 Click to see details
0.016 4.7e-1 0.188 1.9e-1 24 Click to see details
0.016 4.7e-1 0.188 1.9e-1 24 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission