miRTarBase - #MIRT530649


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pre-miRNA Information
pre-miRNA hsa-mir-1539   
Genomic Coordinates chr18: 49487373 - 49487422
Synonyms MIRN1539, hsa-mir-1539, MIR1539
Description Homo sapiens miR-1539 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1539
Sequence 30| UCCUGCGCGUCCCAGAUGCCC |50
Evidence Experimental
Experiments ChIP-seq
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN191880 21 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1202005680 4 dbSNP
rs574136841 6 dbSNP
rs368524614 14 dbSNP
rs1477787264 15 dbSNP
rs1364420621 16 dbSNP
rs933051089 17 dbSNP
rs111715115 19 dbSNP
rs888755072 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ETV5   
Synonyms ERM
Description ETS variant 5
Transcript NM_004454   
Expression
Putative miRNA Targets on ETV5
3'UTR of ETV5
(miRNA target sites are highlighted)		 
>ETV5|NM_004454|3'UTR
   1 GTTTCTGAGTGGCGGAGTGGCCAAACCCTAGAGCTAGCAGTTCCCATTCAGGCAAACAAGGGCAGTGGTTTTGTTTGTGT
  81 TTTTGGTTGTTCCTAAAGCTTGCCCTTTGAGTATTATCTGGAGAACCCAAGCTGTCTCTGGATTGGCACCCTTAAAGACA
 161 GATACATTGGCTGGGGAGTGGGAACAGGGAGGGGCAGAAAACCACCAAAAGGCCAGTGCCTCAACTCTTGATTCTGATGA
 241 GGTTTCTGGGAAGAGATCAAAATGGAGTCTCCTTACCATGGACAATACATGCAAAGCAATATCTTGTTCAGGTTAGTACC
 321 CGCAAAACGGGACATAGTATGTGACAATCTGCATCGATCATGGACTACTAAATGCCTTTACATAGAAGGGCTCTGATTTG
 401 CACAATTTGTTGAAAAATCACAAACCCATAGAAAAGTAAGTAGGCTAAGTTGGGGAGGCTCAAACCATTAAGGGTTAAAA
 481 ATACATCTTAAACATTGGAAAGCTCTTCTAGCTGAATCTGAAATATTACCCCTTGTCTAGAAAAAGGGGGGCAGTCAGAA
 561 CAGCTGTTCCCCACTCCGTGGTTCTCAAAATCATAAACCATGGCTACTCTTGGGAACCACCCGGCCATGTGGTCGCCAAG
 641 TAGAGCAAGCCCCCTTTCTCTTCCCAATCACGTGGCTGAGTGTGGATGACTTTTATTTTAGGAGAAGGGCGATTAACACT
 721 TTTGACAGTATTTTGTTTTGCCCTGATTTGGGGGATTGTTTTGTTTTGGTGGTTGTTTTGGAAAAACAGTTTATAAACTG
 801 ATTTTTGTAGTTTTGGTATTTAAAGCAAAAAAACGAAAAACAAAAAACAAAAACAAACCTTTTGGTAACTGTGCACTGTG
 881 TCCTTTAGCCAGGGCCGTGCCAACTTATGAAGACACTGCAGCTTGAGAGGGGCTTTGCTGAGGCTTCCCCTTGGCCATGT
 961 GAAAGCCCGCCTTGTTGCCTGCTTTGTGCTTTCTGCACCAGACAACCTGATGGAACATTTGCACCTGAGTTGTACATTTT
1041 TGAAGTGTGCAGGGCAGCCTGGACACAAGCTTAGATTCTCTATGTATAGTTCCCCGTGTTCACTAACATGCCCTCTCTGG
1121 AAAGCATATGTATATAACATGTGTCATGTCCTTTGGAAACCTGGTCACCTGGTGAAAACCCTTGGGATTCTTCCCTGGGC
1201 ATGACTGATGACAATTTCCATTTCATCAGTTTGTTTTGTTTTCCTTTTTCTTTAAATCTTGGACTTTAAACCCTACCTGT
1281 GTGATTCAGTAGGGTTTGAGACTTACGTGTGATACTGACAGGTAAGCAACAGTGCTAGCATTCTAGATTCCTGCCTTTTT
1361 TTAAAAAGAAATTATTCTCATTGCTGTATTATATTGGAAAAGTTTTAAACAACCAAGCTAAAGCTATGTGAAAGTTGAGC
1441 TCAAAGTAGAGGAAAAGTTACTGGTGGTACCTTGCTGCCTGCTCTGCTGGTAGAATTCTGTGCTCCCCGTGACACTTAGT
1521 ACATTAAGAATGACTACACTGTTCCTCGTATGTGAAGGAGGCAGTGCTGACTCCGTGAGTGTGAGACACGTGCTTTGAAC
1601 TGCTTTTCTATTCATGGAGCACTCCATAGTCTCAAACTGTCCCCCTTATGACCAACAGCACATTTGTGAAGAGGTTCGCA
1681 GGGATAAGGGGTGCACTTTATAGCTATGGAAACATGAGATTCTCCTCTATTGGAAGCTAATTAGCCCACAAAGGTGGTAA
1761 ACCTGTAGATTGGGCCTTAATTAGCATTGTACTCTAATCAAAGGACTCTTTCTAAACCATATTTATAGCTTTCTTAACCT
1841 ACACATAGTCTATACATAGATGCATATTTTACCCCCAGCTGGCTAGAGATTTATTTGTTGTAAATGCTGTATAGATTTGG
1921 TTTTCCTTTCTTTACTTACCCTGGTTTGGATTTTTTTTTTTTTTCTTTTGAATGGATTTATGCTGTCTTAGCAATATGAC
2001 AATAATCCTCTGTAGCTTGAGCTACCCCTCCCCTGCTGTAACTTACGTGACCTGTGCTGTCACTGGGCATAGGACAGCGG
2081 CATCACGGTTGCATTCCCATTGGACTCATGCACCTCCCGGATGGTTTTTGTTTTTTTCGGGGGTTCTTTGGGGTTTGTTT
2161 GTTTGCTTCTTTTCCAGAGTGTGGAAAGTCTACAGTGCAGAAAGGCTTGAACCTGCCAGCTGATTTGAAATACTTTCCCC
2241 TGCGCAGGGCCGTATGCATCCTGCCAAGCTGCGTTATATTCTGTACTGTGTACAATAAAGAAGTTTGCTTTTCGTTTACC
2321 AA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cccguagacccuGCGCGUCCu 5'
                      :||||||| 
Target 5' aatactttccccTGCGCAGGg 3'
 2229 - 2249 141.00 -14.90
2 
miRNA  3' cccGUAGACCCU--GCGCGUCCu 5'
             |||:|  ||  :|:||||| 
Target 5' gtaCATTTTTGAAGTGTGCAGGg 3'
 1032 - 1054 140.00 -18.30
3 
miRNA  3' cccGUAGACCCU-----GCGCGUCCu 5'
             |||:|| ||     : |||||| 
Target 5' gcaCATTTGTGAAGAGGTTCGCAGGg 3'
 1658 - 1683 126.00 -17.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30190194 12 COSMIC
COSN9539639 149 COSMIC
COSN30106460 213 COSMIC
COSN8488853 351 COSMIC
COSN28201830 493 COSMIC
COSN21564455 708 COSMIC
COSN31532463 720 COSMIC
COSN9002820 763 COSMIC
COSN20090964 774 COSMIC
COSN20099479 841 COSMIC
COSN9539637 896 COSMIC
COSN30165891 925 COSMIC
COSN26569306 929 COSMIC
COSN22884753 969 COSMIC
COSN7628481 1291 COSMIC
COSN31536206 1318 COSMIC
COSN31540632 1332 COSMIC
COSN31518229 1354 COSMIC
COSN26649182 1362 COSMIC
COSN20090963 1363 COSMIC
COSN32056863 1414 COSMIC
COSN26557339 1440 COSMIC
COSN30259867 1561 COSMIC
COSN30174458 1583 COSMIC
COSN31529750 1613 COSMIC
COSN25688404 1624 COSMIC
COSN31548150 1727 COSMIC
COSN29283543 1732 COSMIC
COSN31480355 1768 COSMIC
COSN20090962 1792 COSMIC
COSN30176039 1897 COSMIC
COSN16666415 1900 COSMIC
COSN8488852 1943 COSMIC
COSN27356697 1964 COSMIC
COSN20099476 1965 COSMIC
COSN27555399 1968 COSMIC
COSN26551403 2243 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1433960235 1 dbSNP
rs752572754 2 dbSNP
rs767462370 3 dbSNP
rs1367542224 4 dbSNP
rs1383314311 10 dbSNP
rs150591038 12 dbSNP
rs774113686 13 dbSNP
rs55787444 14 dbSNP
rs770312835 22 dbSNP
rs748691574 26 dbSNP
rs375024691 28 dbSNP
rs1224487731 29 dbSNP
rs769065187 33 dbSNP
rs747190559 39 dbSNP
rs1189439097 40 dbSNP
rs200620112 41 dbSNP
rs372047664 46 dbSNP
rs745982504 47 dbSNP
rs777814923 50 dbSNP
rs1426827282 57 dbSNP
rs141729479 62 dbSNP
rs983140368 63 dbSNP
rs929824410 73 dbSNP
rs1216937187 81 dbSNP
rs927746348 99 dbSNP
rs981948732 99 dbSNP
rs564128315 104 dbSNP
rs1036413190 108 dbSNP
rs1383368782 110 dbSNP
rs567336536 119 dbSNP
rs1023073167 121 dbSNP
rs1296178090 122 dbSNP
rs1383103866 123 dbSNP
rs115484532 134 dbSNP
rs1310098063 136 dbSNP
rs1320953492 148 dbSNP
rs374865157 151 dbSNP
rs1334873058 165 dbSNP
rs113758949 166 dbSNP
rs1380209628 167 dbSNP
rs1208208120 177 dbSNP
rs1360811786 177 dbSNP
rs1289291483 181 dbSNP
rs985880902 187 dbSNP
rs1243873861 189 dbSNP
rs1462683199 191 dbSNP
rs1436924226 194 dbSNP
rs931800955 195 dbSNP
rs560518951 205 dbSNP
rs923134385 215 dbSNP
rs1392217029 220 dbSNP
rs976014150 231 dbSNP
rs1362602618 237 dbSNP
rs1164069744 238 dbSNP
rs1457131889 240 dbSNP
rs956861627 253 dbSNP
rs903445410 257 dbSNP
rs777843855 263 dbSNP
rs979814802 271 dbSNP
rs998329824 283 dbSNP
rs968086042 288 dbSNP
rs899576259 303 dbSNP
rs1166969821 306 dbSNP
rs1308811905 310 dbSNP
rs1326784799 313 dbSNP
rs1427017731 321 dbSNP
rs1419063613 322 dbSNP
rs540733328 323 dbSNP
rs1012318032 324 dbSNP
rs1039458315 328 dbSNP
rs1251711197 329 dbSNP
rs1481061080 339 dbSNP
rs896644494 351 dbSNP
rs1179344720 355 dbSNP
rs941029258 356 dbSNP
rs1035172685 359 dbSNP
rs1213574562 360 dbSNP
rs994363796 368 dbSNP
rs897370905 378 dbSNP
rs888150418 379 dbSNP
rs1038623750 382 dbSNP
rs1469280596 384 dbSNP
rs941652262 387 dbSNP
rs762753585 389 dbSNP
rs752259118 390 dbSNP
rs927879105 403 dbSNP
rs764596642 404 dbSNP
rs1299491861 405 dbSNP
rs1348467184 407 dbSNP
rs1283868612 408 dbSNP
rs1295773120 413 dbSNP
rs1230364773 414 dbSNP
rs1050165252 417 dbSNP
rs1217579341 419 dbSNP
rs931750128 425 dbSNP
rs1308132647 426 dbSNP
rs1324933221 427 dbSNP
rs1206939356 443 dbSNP
rs1272748689 450 dbSNP
rs1441605571 461 dbSNP
rs1482940861 467 dbSNP
rs915982412 469 dbSNP
rs1392772597 473 dbSNP
rs1479714480 477 dbSNP
rs1191097947 495 dbSNP
rs1423901681 502 dbSNP
rs187947560 511 dbSNP
rs1040589550 513 dbSNP
rs6774595 514 dbSNP
rs923822275 519 dbSNP
rs1033394584 521 dbSNP
rs977464448 523 dbSNP
rs979377726 524 dbSNP
rs753398842 526 dbSNP
rs1451757891 529 dbSNP
rs116538580 531 dbSNP
rs375968196 532 dbSNP
rs1434313119 533 dbSNP
rs1362830791 537 dbSNP
rs1216391994 539 dbSNP
rs1270093860 547 dbSNP
rs544162527 547 dbSNP
rs1223714174 550 dbSNP
rs1294463602 552 dbSNP
rs762148290 561 dbSNP
rs1035130666 566 dbSNP
rs1193585277 571 dbSNP
rs900044409 573 dbSNP
rs994704608 577 dbSNP
rs961575808 578 dbSNP
rs1005675462 579 dbSNP
rs370459210 592 dbSNP
rs1163805070 598 dbSNP
rs1367258432 606 dbSNP
rs1403388005 609 dbSNP
rs1322879159 621 dbSNP
rs1017596859 622 dbSNP
rs1345261373 623 dbSNP
rs1318564543 626 dbSNP
rs1302479058 627 dbSNP
rs1047140487 631 dbSNP
rs993867066 634 dbSNP
rs1005840318 635 dbSNP
rs906429940 636 dbSNP
rs1449202119 639 dbSNP
rs573704429 655 dbSNP
rs769770003 657 dbSNP
rs377678958 659 dbSNP
rs1183893969 666 dbSNP
rs764775607 666 dbSNP
rs947858813 667 dbSNP
rs1162391031 671 dbSNP
rs901567517 672 dbSNP
rs1156818677 674 dbSNP
rs1388079817 675 dbSNP
rs1040124144 685 dbSNP
rs935122981 688 dbSNP
rs1338851343 691 dbSNP
rs562266613 692 dbSNP
rs8310 695 dbSNP
rs879890890 695 dbSNP
rs1173479490 701 dbSNP
rs936057164 706 dbSNP
rs1379902771 707 dbSNP
rs926080173 708 dbSNP
rs923839142 710 dbSNP
rs967435341 711 dbSNP
rs774904968 726 dbSNP
rs1257872284 731 dbSNP
rs1251964820 734 dbSNP
rs1440291127 740 dbSNP
rs1044019324 750 dbSNP
rs1183694852 753 dbSNP
rs1186371380 758 dbSNP
rs1484522484 767 dbSNP
rs1473446440 774 dbSNP
rs1179993278 778 dbSNP
rs181092644 780 dbSNP
rs1279079482 787 dbSNP
rs1470345562 789 dbSNP
rs764588794 792 dbSNP
rs1174353447 802 dbSNP
rs1400366788 821 dbSNP
rs540366576 833 dbSNP
rs573326213 834 dbSNP
rs1329758040 835 dbSNP
rs977011851 835 dbSNP
rs1408374271 841 dbSNP
rs964266811 842 dbSNP
rs397688429 843 dbSNP
rs189882545 848 dbSNP
rs397792412 848 dbSNP
rs5855080 848 dbSNP
rs745736257 848 dbSNP
rs750686487 848 dbSNP
rs869190435 848 dbSNP
rs1258928350 849 dbSNP
rs184314868 849 dbSNP
rs1018364007 851 dbSNP
rs1238296633 854 dbSNP
rs1251025872 858 dbSNP
rs146951055 860 dbSNP
rs1289130467 864 dbSNP
rs1411737846 871 dbSNP
rs1477739505 873 dbSNP
rs1168772084 880 dbSNP
rs1353804232 883 dbSNP
rs1428229446 889 dbSNP
rs1307756585 895 dbSNP
rs1366558120 896 dbSNP
rs183515420 897 dbSNP
rs1312447886 904 dbSNP
rs1397006017 909 dbSNP
rs1299814188 911 dbSNP
rs952545813 918 dbSNP
rs1313617891 925 dbSNP
rs1404849622 932 dbSNP
rs375643294 936 dbSNP
rs994223717 937 dbSNP
rs1453741752 943 dbSNP
rs763309014 950 dbSNP
rs1413333457 953 dbSNP
rs1490444797 958 dbSNP
rs1160745519 968 dbSNP
rs1473905056 969 dbSNP
rs575335256 974 dbSNP
rs906229693 976 dbSNP
rs1451123651 978 dbSNP
rs1256398163 992 dbSNP
rs990758104 996 dbSNP
rs11557887 997 dbSNP
rs1392290798 1001 dbSNP
rs775660031 1005 dbSNP
rs1447941036 1009 dbSNP
rs1168162133 1022 dbSNP
rs1386320286 1030 dbSNP
rs80092904 1037 dbSNP
rs1012130470 1043 dbSNP
rs1443761353 1047 dbSNP
rs928004846 1053 dbSNP
rs1385761538 1057 dbSNP
rs1320579761 1065 dbSNP
rs1366717631 1070 dbSNP
rs1259463748 1075 dbSNP
rs1204318905 1076 dbSNP
rs1225779247 1078 dbSNP
rs1296418051 1081 dbSNP
rs1054006478 1082 dbSNP
rs936544828 1082 dbSNP
rs972876726 1095 dbSNP
rs1269871125 1096 dbSNP
rs1205623430 1113 dbSNP
rs1230322910 1125 dbSNP
rs961841587 1126 dbSNP
rs1463597536 1130 dbSNP
rs1017125735 1132 dbSNP
rs1243911679 1134 dbSNP
rs1425924130 1136 dbSNP
rs1163069930 1139 dbSNP
rs1368418491 1140 dbSNP
rs1454810801 1141 dbSNP
rs1041839688 1146 dbSNP
rs1005792546 1147 dbSNP
rs1432251713 1164 dbSNP
rs1319486777 1183 dbSNP
rs946048289 1196 dbSNP
rs922567759 1201 dbSNP
rs13065099 1211 dbSNP
rs1342472629 1214 dbSNP
rs954248404 1219 dbSNP
rs976730730 1220 dbSNP
rs1316763915 1224 dbSNP
rs1320856136 1227 dbSNP
rs1228997985 1233 dbSNP
rs1269929311 1235 dbSNP
rs1327180267 1258 dbSNP
rs964233950 1260 dbSNP
rs1264019661 1261 dbSNP
rs141261071 1273 dbSNP
rs1180309998 1287 dbSNP
rs1390034304 1293 dbSNP
rs984676935 1294 dbSNP
rs952937861 1302 dbSNP
rs1185052535 1305 dbSNP
rs995801975 1306 dbSNP
rs1323084152 1307 dbSNP
rs1359405933 1314 dbSNP
rs1421121071 1324 dbSNP
rs1416579211 1342 dbSNP
rs537801506 1343 dbSNP
rs1410141077 1345 dbSNP
rs1163309365 1348 dbSNP
rs567275710 1362 dbSNP
rs1040516561 1363 dbSNP
rs1279481431 1368 dbSNP
rs999309565 1369 dbSNP
rs549012061 1371 dbSNP
rs1313997222 1373 dbSNP
rs1208368878 1374 dbSNP
rs902333747 1375 dbSNP
rs1481175076 1383 dbSNP
rs761391040 1391 dbSNP
rs1250288473 1392 dbSNP
rs1465137294 1395 dbSNP
rs576721347 1412 dbSNP
rs776343931 1426 dbSNP
rs1211781253 1430 dbSNP
rs1467955878 1433 dbSNP
rs533643040 1435 dbSNP
rs1024611640 1439 dbSNP
rs1228958589 1441 dbSNP
rs1434382079 1442 dbSNP
rs566598671 1442 dbSNP
rs1358147666 1449 dbSNP
rs1054975302 1455 dbSNP
rs1228152216 1460 dbSNP
rs1309565253 1463 dbSNP
rs776696023 1465 dbSNP
rs939348153 1468 dbSNP
rs1032291260 1470 dbSNP
rs1001101333 1474 dbSNP
rs1217492761 1481 dbSNP
rs1300232614 1482 dbSNP
rs1439403162 1486 dbSNP
rs1349796571 1487 dbSNP
rs928026355 1493 dbSNP
rs973209773 1494 dbSNP
rs1482916976 1498 dbSNP
rs192057120 1509 dbSNP
rs1248903219 1516 dbSNP
rs946102079 1519 dbSNP
rs1166910877 1523 dbSNP
rs1424052372 1536 dbSNP
rs1449662828 1537 dbSNP
rs556850976 1547 dbSNP
rs533361357 1548 dbSNP
rs1453792136 1573 dbSNP
rs909969294 1574 dbSNP
rs1040999397 1575 dbSNP
rs1222417540 1576 dbSNP
rs9831679 1581 dbSNP
rs911450201 1583 dbSNP
rs1292966383 1586 dbSNP
rs1365995904 1589 dbSNP
rs138737120 1590 dbSNP
rs1204755754 1592 dbSNP
rs1229179102 1598 dbSNP
rs918722397 1621 dbSNP
rs1320387811 1624 dbSNP
rs1028543768 1645 dbSNP
rs1343113216 1648 dbSNP
rs1251877332 1649 dbSNP
rs1464951587 1652 dbSNP
rs772088300 1653 dbSNP
rs746799982 1662 dbSNP
rs1245761032 1677 dbSNP
rs777647675 1678 dbSNP
rs1018643631 1680 dbSNP
rs1415903425 1694 dbSNP
rs373330948 1694 dbSNP
rs999613500 1695 dbSNP
rs970443407 1702 dbSNP
rs1024755316 1707 dbSNP
rs1437292641 1708 dbSNP
rs1318789981 1718 dbSNP
rs1364679002 1721 dbSNP
rs1449237168 1724 dbSNP
rs1275904440 1729 dbSNP
rs546500009 1743 dbSNP
rs1438018554 1750 dbSNP
rs561934372 1752 dbSNP
rs1228317540 1756 dbSNP
rs902238506 1762 dbSNP
rs1269309983 1765 dbSNP
rs1022003708 1781 dbSNP
rs1209988706 1784 dbSNP
rs959063529 1788 dbSNP
rs1446016946 1790 dbSNP
rs1010661334 1792 dbSNP
rs1471686723 1795 dbSNP
rs1187151234 1797 dbSNP
rs1412533991 1802 dbSNP
rs1032671209 1806 dbSNP
rs1000750775 1808 dbSNP
rs1387964995 1809 dbSNP
rs1415293562 1810 dbSNP
rs895017313 1816 dbSNP
rs902437013 1819 dbSNP
rs540652113 1825 dbSNP
rs573241800 1830 dbSNP
rs1447689976 1833 dbSNP
rs1289532661 1838 dbSNP
rs1372013209 1838 dbSNP
rs1229726068 1843 dbSNP
rs772151795 1844 dbSNP
rs1349295789 1849 dbSNP
rs564619897 1856 dbSNP
rs1037005631 1858 dbSNP
rs111652985 1859 dbSNP
rs1192808083 1872 dbSNP
rs1209839281 1884 dbSNP
rs1252477760 1887 dbSNP
rs1473560140 1890 dbSNP
rs909928054 1898 dbSNP
rs746724616 1900 dbSNP
rs942695572 1901 dbSNP
rs1231303202 1930 dbSNP
rs984211107 1931 dbSNP
rs932795868 1935 dbSNP
rs897669502 1938 dbSNP
rs1308964014 1941 dbSNP
rs1483543400 1948 dbSNP
rs1276959321 1949 dbSNP
rs1209198246 1950 dbSNP
rs1311929335 1957 dbSNP
rs1048876696 1961 dbSNP
rs1233252299 1965 dbSNP
rs4686724 1965 dbSNP
rs931545966 1965 dbSNP
rs200001879 1966 dbSNP
rs372945070 1967 dbSNP
rs1483910686 1968 dbSNP
rs369930193 1968 dbSNP
rs1203005302 1969 dbSNP
rs151192919 1970 dbSNP
rs6768355 1970 dbSNP
rs1167860783 1971 dbSNP
rs1169437921 1971 dbSNP
rs1234441758 1971 dbSNP
rs1428209239 1971 dbSNP
rs1491499564 1971 dbSNP
rs376722374 1971 dbSNP
rs547971733 1971 dbSNP
rs1349141887 1972 dbSNP
rs1439793424 1973 dbSNP
rs1297859232 1976 dbSNP
rs888554845 1980 dbSNP
rs921469596 1987 dbSNP
rs1356904792 1990 dbSNP
rs1287234192 1992 dbSNP
rs1265413556 1993 dbSNP
rs1468090641 2002 dbSNP
rs1189521990 2009 dbSNP
rs976992465 2011 dbSNP
rs1170126253 2023 dbSNP
rs1409831212 2023 dbSNP
rs1351962682 2024 dbSNP
rs965631346 2025 dbSNP
rs1459930390 2027 dbSNP
rs868782688 2028 dbSNP
rs1032360075 2033 dbSNP
rs1460413941 2037 dbSNP
rs1310644327 2042 dbSNP
rs188833358 2046 dbSNP
rs966787916 2047 dbSNP
rs972879081 2051 dbSNP
rs753580535 2054 dbSNP
rs1263600937 2057 dbSNP
rs1334280098 2061 dbSNP
rs1209368157 2063 dbSNP
rs1270273937 2064 dbSNP
rs1463749123 2078 dbSNP
rs1177942434 2079 dbSNP
rs917666895 2080 dbSNP
rs182954679 2085 dbSNP
rs959386799 2086 dbSNP
rs1010651164 2087 dbSNP
rs1474613632 2088 dbSNP
rs1472928044 2096 dbSNP
rs894963403 2098 dbSNP
rs555039083 2099 dbSNP
rs76905089 2100 dbSNP
rs534014769 2108 dbSNP
rs566407362 2109 dbSNP
rs1483034350 2116 dbSNP
rs1020850831 2118 dbSNP
rs906425770 2119 dbSNP
rs866170476 2121 dbSNP
rs965884885 2129 dbSNP
rs1228904888 2130 dbSNP
rs1315658758 2131 dbSNP
rs1267990674 2138 dbSNP
rs1315192153 2138 dbSNP
rs1019652138 2139 dbSNP
rs1004180554 2140 dbSNP
rs888480632 2141 dbSNP
rs1199051509 2142 dbSNP
rs191454967 2151 dbSNP
rs932754635 2152 dbSNP
rs921365255 2156 dbSNP
rs539607042 2157 dbSNP
rs569102015 2162 dbSNP
rs755202046 2166 dbSNP
rs1428302795 2168 dbSNP
rs1416782278 2172 dbSNP
rs1157936707 2173 dbSNP
rs568261982 2174 dbSNP
rs1377779258 2176 dbSNP
rs1467421800 2179 dbSNP
rs1387840975 2181 dbSNP
rs1310895016 2185 dbSNP
rs755695637 2193 dbSNP
rs1374591108 2204 dbSNP
rs187437742 2205 dbSNP
rs995937648 2215 dbSNP
rs369220565 2219 dbSNP
rs924855345 2221 dbSNP
rs978111805 2224 dbSNP
rs772516588 2225 dbSNP
rs1037323325 2229 dbSNP
rs751933827 2229 dbSNP
rs1423524211 2234 dbSNP
rs1414714142 2240 dbSNP
rs949531850 2242 dbSNP
rs376109002 2243 dbSNP
rs914932652 2244 dbSNP
rs989176808 2251 dbSNP
rs959086466 2252 dbSNP
rs1033406636 2254 dbSNP
rs1176087496 2255 dbSNP
rs1247984323 2258 dbSNP
rs1434582706 2262 dbSNP
rs1209945725 2268 dbSNP
rs1003338244 2269 dbSNP
rs1270790345 2272 dbSNP
rs764390861 2273 dbSNP
rs1170418139 2275 dbSNP
rs1352650298 2276 dbSNP
rs1441591999 2278 dbSNP
rs754642902 2279 dbSNP
rs1015501896 2282 dbSNP
rs1369782938 2286 dbSNP
rs1439067549 2292 dbSNP
rs1004574826 2313 dbSNP
rs1343339208 2314 dbSNP
rs979101328 2320 dbSNP
rs529522735 2323 dbSNP
rs1307380498 2325 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 2119.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cccguagacccugcGCGUCCu 5'
                        ||:| | 
Target 5' ---------agggcCGUAUGc 3'
 		1 - 12
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000306376.5 | 3UTR | AGGGCCGUAUGCAUCCUGCCAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.698 7.5e-5 0.624 5.6e-4 24 Click to see details
GSE28260 Renal cortex and medulla -0.388 9.5e-2 -0.247 2.1e-1 13 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
13 hsa-miR-1539 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT447455 IFNK interferon kappa 2 2
MIRT467605 SLC7A5 solute carrier family 7 member 5 2 2
MIRT492748 PER1 period circadian clock 1 2 10
MIRT502664 CTC1 CST telomere replication complex component 1 2 12
MIRT526463 OSBPL5 oxysterol binding protein like 5 2 2
MIRT530649 ETV5 ETS variant 5 2 2
MIRT564511 DUSP3 dual specificity phosphatase 3 2 2
MIRT633714 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT637371 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT678462 GLYAT glycine-N-acyltransferase 2 2
MIRT689346 ZNF83 zinc finger protein 83 2 2
MIRT712905 TGFA transforming growth factor alpha 2 2
MIRT717041 KRTAP4-9 keratin associated protein 4-9 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miR-1539 Atorvastatin approved 60823 Microarray PC3 prostate cancer cells 23936432 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1539 Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-1539 Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-1539 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-1539 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-1539 Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-1539 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-1539 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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