pre-miRNA Information
pre-miRNA hsa-mir-6501   
Genomic Coordinates chr21: 33550662 - 33550728
Description Homo sapiens miR-6501 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6501-5p
Sequence 3| AGUUGCCAGGGCUGCCUUUGGU |24
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
1055619 20 ClinVar
COSM5974214 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs756127353 5 dbSNP
rs764400023 6 dbSNP
rs753967693 8 dbSNP
rs1283296362 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CHRNB1   
Synonyms ACHRB, CHRNB, CMS1D, CMS2A, CMS2C, SCCMS
Description cholinergic receptor nicotinic beta 1 subunit
Transcript NM_000747   
Expression
Putative miRNA Targets on CHRNB1
3'UTR of CHRNB1
(miRNA target sites are highlighted)
>CHRNB1|NM_000747|3'UTR
   1 AGACTGGAGGGTTGAGACCCAGGCCCCCTGCCAGTTGAAGTGAGAGTTTGGTGATACTGTCAAGCCCTATCCTTCTCTGC
  81 CTCTTAACTCCTTCACGAGGAATCTGGGCCTCTTATTTCGTTTCTGGGGACTGCATTGGACTGAGGGCTGGGTAGGCAGG
 161 TGTCTTGGACCCACCTGAAATGCAGTATCATCTGATTTACTCTTTGGGATCTTGAAGAAGCTCTTTTGGGTATCAACACC
 241 TAGGTCGCCAGTGAAATAGAACACAGAACAGGAACTAGATTATAAGCCTTATGAGGTCAAGAAATGTGACTTGGCCGGGC
 321 GCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATCACCTGAGGTCGGGAGTTTGAGACCAG
 401 CCCGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCCAGGTGTGGTGGTACATGCCTGTAATCCCAG
 481 CTACTAGGGAGGCTGAGGCAGGAGAATCACTCGAACCCGGGAGGCAGAGGTTGCAGTGAGTCAAGATCACGCCATTGCAC
 561 TCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAGTGTCTTGTTCACTGCAGCATGCCCAGTGCCACG
 641 CACAGGTGCTGACCTATAGTAAGTGCTTAACATTTGTTGAATAGGGGAAAGAAATTTCCGGAAGTAAATACAGCAATTAA
 721 TAATGTTTATAAGCTGGGCATGGTCGCTCAGGCCAGTAATCCCAGTGACTTAGGAGGCTGAGGTGGGAGGATTACTTGAA
 801 ACCCACAGTTTGAGACCAGCCTGGGCAACATAGTGAGACCCTGTCTCTAAAAAAATAAAAATAGAAATAAAGTAGTGCTT
 881 ATTGTTTGCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugGUUUCCGUCGGGACCGUUGa 5'
            ::|:  |||||: |||||| 
Target 5' ttTGAGACCAGCCTGGGCAACa 3'
809 - 830 136.00 -18.50
2
miRNA  3' ugguuuccGUCGGGACCGUUGa 5'
                  |||||: |||||| 
Target 5' ttgcactcCAGCCTGGGCAACa 3'
555 - 576 134.00 -18.50
3
miRNA  3' ugGUUUCCGUC-GGGACCGUUGa 5'
            ::|||  ||  ::|||::|: 
Target 5' gtTGAAGTGAGAGTTTGGTGATa 3'
34 - 56 104.00 -6.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
256770 19 ClinVar
325108 32 ClinVar
325109 69 ClinVar
325110 72 ClinVar
890333 80 ClinVar
890334 121 ClinVar
325111 137 ClinVar
325112 282 ClinVar
890896 288 ClinVar
890897 344 ClinVar
890898 370 ClinVar
890899 404 ClinVar
325113 434 ClinVar
890900 513 ClinVar
892131 702 ClinVar
325114 750 ClinVar
325115 756 ClinVar
892132 766 ClinVar
892133 776 ClinVar
325116 779 ClinVar
325117 844 ClinVar
COSN30175275 14 COSMIC
COSN30144397 29 COSMIC
COSN30108183 35 COSMIC
COSN9322795 36 COSMIC
COSN31485133 54 COSMIC
COSN31516667 55 COSMIC
COSN31613808 67 COSMIC
COSN18013617 69 COSMIC
COSN1201293 77 COSMIC
COSN30193038 78 COSMIC
COSN26970725 83 COSMIC
COSN1201295 90 COSMIC
COSN32069287 184 COSMIC
COSN9322796 224 COSMIC
COSN31522339 242 COSMIC
COSN16379520 292 COSMIC
COSN30237008 373 COSMIC
COSN9322797 398 COSMIC
COSN22899029 704 COSMIC
COSN22629758 886 COSMIC
rs2302764 69 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs768877353 3 dbSNP
rs1287617998 6 dbSNP
rs748542529 8 dbSNP
rs1199526444 10 dbSNP
rs1480977718 10 dbSNP
rs1253591150 13 dbSNP
rs770263810 15 dbSNP
rs1190105255 18 dbSNP
rs79747991 19 dbSNP
rs1004764077 21 dbSNP
rs762522013 24 dbSNP
rs1157368856 25 dbSNP
rs1021566770 27 dbSNP
rs1471606445 28 dbSNP
rs770407171 29 dbSNP
rs75282248 32 dbSNP
rs759202748 34 dbSNP
rs370459317 35 dbSNP
rs752487148 36 dbSNP
rs963258690 39 dbSNP
rs1224712642 40 dbSNP
rs1452095511 42 dbSNP
rs760591391 43 dbSNP
rs764059344 44 dbSNP
rs1311290164 51 dbSNP
rs1377028214 52 dbSNP
rs1333395117 61 dbSNP
rs760190833 66 dbSNP
rs2302764 69 dbSNP
rs886053405 72 dbSNP
rs1227981864 73 dbSNP
rs1031593513 75 dbSNP
rs1349068545 84 dbSNP
rs1305322173 98 dbSNP
rs1449942133 101 dbSNP
rs1349755546 111 dbSNP
rs73233980 117 dbSNP
rs1340226289 121 dbSNP
rs189934411 122 dbSNP
rs1159510117 125 dbSNP
rs987550443 127 dbSNP
rs182995220 137 dbSNP
rs964929592 143 dbSNP
rs1201231089 146 dbSNP
rs1246005002 148 dbSNP
rs547533724 159 dbSNP
rs1219503836 160 dbSNP
rs973954683 167 dbSNP
rs1268826249 170 dbSNP
rs912740834 183 dbSNP
rs1344376387 197 dbSNP
rs1199280272 200 dbSNP
rs1327330420 215 dbSNP
rs1285584219 217 dbSNP
rs749808517 219 dbSNP
rs1220133192 228 dbSNP
rs1256062314 231 dbSNP
rs1273626380 235 dbSNP
rs1433478713 235 dbSNP
rs565720830 240 dbSNP
rs945499476 242 dbSNP
rs929507535 248 dbSNP
rs1385914900 260 dbSNP
rs978254553 270 dbSNP
rs982449266 274 dbSNP
rs1424168392 277 dbSNP
rs3855924 282 dbSNP
rs938321792 283 dbSNP
rs548074838 288 dbSNP
rs894199982 289 dbSNP
rs948600692 290 dbSNP
rs1463734054 294 dbSNP
rs1055150693 295 dbSNP
rs1391525937 305 dbSNP
rs1312031387 313 dbSNP
rs1276932407 317 dbSNP
rs186256847 320 dbSNP
rs1171990426 321 dbSNP
rs1043254156 322 dbSNP
rs904447212 323 dbSNP
rs1415969562 324 dbSNP
rs369029563 333 dbSNP
rs998768072 334 dbSNP
rs537009813 344 dbSNP
rs1358419697 356 dbSNP
rs1363312463 358 dbSNP
rs1173686966 361 dbSNP
rs890485309 366 dbSNP
rs1411592653 367 dbSNP
rs552159525 370 dbSNP
rs201698552 371 dbSNP
rs1245025501 379 dbSNP
rs570897543 382 dbSNP
rs1483046776 383 dbSNP
rs965126692 385 dbSNP
rs1231143483 386 dbSNP
rs1255934538 390 dbSNP
rs973602238 394 dbSNP
rs1028196488 397 dbSNP
rs200092486 398 dbSNP
rs1274500712 404 dbSNP
rs1046884082 411 dbSNP
rs200997311 413 dbSNP
rs1339513589 423 dbSNP
rs1314228832 424 dbSNP
rs150545965 434 dbSNP
rs1377901848 437 dbSNP
rs377347549 450 dbSNP
rs1300875049 451 dbSNP
rs553467940 456 dbSNP
rs928190378 459 dbSNP
rs1307399316 462 dbSNP
rs1427731200 464 dbSNP
rs779312757 465 dbSNP
rs1165490424 466 dbSNP
rs1430969041 468 dbSNP
rs938352868 472 dbSNP
rs1411836012 474 dbSNP
rs574914826 477 dbSNP
rs1470945340 480 dbSNP
rs1179351706 484 dbSNP
rs1197471776 485 dbSNP
rs915677410 496 dbSNP
rs1203705643 497 dbSNP
rs948440482 498 dbSNP
rs1266701016 503 dbSNP
rs1156718063 506 dbSNP
rs1244804394 513 dbSNP
rs1320763067 516 dbSNP
rs190725123 519 dbSNP
rs1229832289 520 dbSNP
rs1307178507 521 dbSNP
rs376989569 530 dbSNP
rs1407928045 537 dbSNP
rs1392723080 547 dbSNP
rs925812172 551 dbSNP
rs1457564358 552 dbSNP
rs1321536547 555 dbSNP
rs996026629 555 dbSNP
rs1348170087 562 dbSNP
rs1028673790 565 dbSNP
rs934481172 571 dbSNP
rs1008652420 572 dbSNP
rs71383492 573 dbSNP
rs1052988302 582 dbSNP
rs890346904 583 dbSNP
rs557679129 587 dbSNP
rs1236122993 589 dbSNP
rs1487903948 593 dbSNP
rs1287507741 595 dbSNP
rs74419302 595 dbSNP
rs879886948 595 dbSNP
rs967109744 595 dbSNP
rs75431011 596 dbSNP
rs1039410445 597 dbSNP
rs900584842 601 dbSNP
rs1301943823 624 dbSNP
rs995371987 632 dbSNP
rs1209692352 640 dbSNP
rs925422068 641 dbSNP
rs1457967396 655 dbSNP
rs576011756 665 dbSNP
rs772514629 669 dbSNP
rs543414258 679 dbSNP
rs1388105013 681 dbSNP
rs1157424600 689 dbSNP
rs1027732568 694 dbSNP
rs775522004 700 dbSNP
rs1005037078 701 dbSNP
rs564887658 702 dbSNP
rs991041666 710 dbSNP
rs1250606114 718 dbSNP
rs1189874423 729 dbSNP
rs138576579 734 dbSNP
rs949372933 742 dbSNP
rs760758832 743 dbSNP
rs1206406121 746 dbSNP
rs540745733 747 dbSNP
rs760896819 750 dbSNP
rs907982001 755 dbSNP
rs80058486 756 dbSNP
rs184167734 758 dbSNP
rs776762809 766 dbSNP
rs1161023525 769 dbSNP
rs969743051 770 dbSNP
rs761728841 776 dbSNP
rs187784840 778 dbSNP
rs556525486 779 dbSNP
rs879131983 783 dbSNP
rs1293130889 811 dbSNP
rs1052853711 812 dbSNP
rs1172294277 819 dbSNP
rs890377476 831 dbSNP
rs530739200 832 dbSNP
rs911815747 835 dbSNP
rs1449586402 836 dbSNP
rs112055321 841 dbSNP
rs1388579773 843 dbSNP
rs886053406 844 dbSNP
rs552120595 845 dbSNP
rs554726863 849 dbSNP
rs967142169 854 dbSNP
rs1350340245 855 dbSNP
rs1256597711 877 dbSNP
rs1199604916 878 dbSNP
rs570743583 879 dbSNP
rs1229433460 888 dbSNP
rs765138462 894 dbSNP
rs1276636184 900 dbSNP
rs544629473 905 dbSNP
rs371036825 908 dbSNP
rs535047964 920 dbSNP
rs1243661646 922 dbSNP
rs1330455436 926 dbSNP
rs1265655496 932 dbSNP
rs1489206812 936 dbSNP
rs1247270172 939 dbSNP
rs1341236874 943 dbSNP
rs192223977 947 dbSNP
rs991089036 948 dbSNP
rs1202334648 957 dbSNP
rs1372766543 959 dbSNP
rs1309223093 964 dbSNP
rs568582265 965 dbSNP
rs1429657957 969 dbSNP
rs1389089276 971 dbSNP
rs1250994214 974 dbSNP
rs1165584364 983 dbSNP
rs1473581837 985 dbSNP
rs773030576 986 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 1140.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uggUUUCCGUC-GGGACCGuuga 5'
             | ||  || ||||| |    
Target 5' ---AUAGUGAGACCCUGUCucua 3'
1 - 20
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 1140.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000306071.2 | 3UTR | CAGCCUGGGCAACAUAGUGAGACCCUGUCUCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000306071.2 | 3UTR | AUAGUGAGACCCUGUCUCUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000306071.2 | 3UTR | CAGCCUGGGCAACAUAGUGAGACCCUGUCUCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
167 hsa-miR-6501-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT156859 FAM126B family with sequence similarity 126 member B 2 2
MIRT173355 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT369102 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT442037 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT442829 AZIN1 antizyme inhibitor 1 2 2
MIRT443729 CCND2 cyclin D2 2 2
MIRT453771 NUCB1 nucleobindin 1 2 10
MIRT453875 IFRD1 interferon related developmental regulator 1 2 12
MIRT454229 OSBPL10 oxysterol binding protein like 10 2 11
MIRT458829 RPUSD2 RNA pseudouridylate synthase domain containing 2 2 2
MIRT459898 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 10
MIRT464162 VMP1 vacuole membrane protein 1 2 15
MIRT495411 SMAD2 SMAD family member 2 2 2
MIRT496906 TRIM56 tripartite motif containing 56 2 2
MIRT498653 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 6
MIRT498706 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT499308 ZNF485 zinc finger protein 485 2 6
MIRT499707 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 10
MIRT499755 CIRH1A UTP4, small subunit processome component 2 6
MIRT499827 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT503691 MAVS mitochondrial antiviral signaling protein 2 2
MIRT512418 LAYN layilin 2 4
MIRT516232 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT522554 MCAM melanoma cell adhesion molecule 2 4
MIRT523760 FBXO27 F-box protein 27 2 4
MIRT525107 PRKD2 protein kinase D2 2 2
MIRT525919 KIAA0391 KIAA0391 2 2
MIRT527246 COMMD6 COMM domain containing 6 2 2
MIRT527564 ADCY7 adenylate cyclase 7 2 2
MIRT528764 CD1D CD1d molecule 2 2
MIRT529362 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT529464 ZNF546 zinc finger protein 546 2 2
MIRT530676 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531635 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT531909 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532172 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534234 SLC25A16 solute carrier family 25 member 16 2 4
MIRT534561 RRAGD Ras related GTP binding D 2 2
MIRT534971 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536738 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT538544 CELF1 CUGBP Elav-like family member 1 2 2
MIRT540462 ZNF71 zinc finger protein 71 2 2
MIRT540554 PPIC peptidylprolyl isomerase C 2 2
MIRT543593 KIAA1549 KIAA1549 2 2
MIRT543963 RNF20 ring finger protein 20 2 2
MIRT544047 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT544670 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT550665 TRAF1 TNF receptor associated factor 1 2 2
MIRT558540 CSNK1G3 casein kinase 1 gamma 3 2 4
MIRT574917 Vmp1 vacuole membrane protein 1 2 9
MIRT575298 Osbpl10 oxysterol binding protein-like 10 2 7
MIRT607960 SNX22 sorting nexin 22 2 2
MIRT610649 TIPRL TOR signaling pathway regulator 2 8
MIRT615899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT617438 CCS copper chaperone for superoxide dismutase 2 2
MIRT617510 C5orf45 MRN complex interacting protein 2 2
MIRT617548 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT620565 WBSCR27 methyltransferase like 27 2 2
MIRT623166 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624161 DGKE diacylglycerol kinase epsilon 2 2
MIRT626090 MKLN1 muskelin 1 2 2
MIRT627010 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627073 SF3A1 splicing factor 3a subunit 1 2 2
MIRT627136 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT627340 TSHZ2 teashirt zinc finger homeobox 2 2 2
MIRT627436 TAS2R5 taste 2 receptor member 5 2 2
MIRT628273 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629091 F2RL1 F2R like trypsin receptor 1 2 4
MIRT629282 UNC13A unc-13 homolog A 2 2
MIRT630122 ARHGEF5 Rho guanine nucleotide exchange factor 5 2 2
MIRT630247 SMTNL2 smoothelin like 2 2 2
MIRT631260 CENPM centromere protein M 2 2
MIRT631336 CD300E CD300e molecule 2 2
MIRT631399 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT632593 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632991 DUSP18 dual specificity phosphatase 18 2 2
MIRT633079 CXorf21 chromosome X open reading frame 21 2 2
MIRT634223 TMEM132B transmembrane protein 132B 2 2
MIRT635046 MYH11 myosin heavy chain 11 2 2
MIRT636444 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636649 CDK4 cyclin dependent kinase 4 2 2
MIRT637129 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT637282 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT637527 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT637783 OLA1 Obg like ATPase 1 2 2
MIRT637920 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT638238 SLC1A5 solute carrier family 1 member 5 2 2
MIRT638444 PLXDC2 plexin domain containing 2 2 2
MIRT639765 GPR45 G protein-coupled receptor 45 2 2
MIRT640437 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT643006 ZNF829 zinc finger protein 829 2 2
MIRT644233 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644661 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644957 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT645086 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645256 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT645861 GBP6 guanylate binding protein family member 6 2 2
MIRT645987 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646502 FAM217B family with sequence similarity 217 member B 2 2
MIRT646811 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT647706 NFX1 nuclear transcription factor, X-box binding 1 2 2
MIRT649657 TEP1 telomerase associated protein 1 2 2
MIRT650550 YIPF4 Yip1 domain family member 4 2 2
MIRT650785 GSR glutathione-disulfide reductase 2 2
MIRT651461 XIAP X-linked inhibitor of apoptosis 2 2
MIRT652098 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT654117 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT658901 DPY19L4 dpy-19 like 4 2 2
MIRT659370 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT662537 MTAP methylthioadenosine phosphorylase 2 2
MIRT662617 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT663491 IYD iodotyrosine deiodinase 2 2
MIRT663899 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT664552 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT664582 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT664953 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT665193 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT665446 WDR17 WD repeat domain 17 2 2
MIRT665894 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT666480 SBNO1 strawberry notch homolog 1 2 2
MIRT666514 RNF170 ring finger protein 170 2 2
MIRT666692 RBM23 RNA binding motif protein 23 2 2
MIRT666791 PSMD1 proteasome 26S subunit, non-ATPase 1 2 2
MIRT667453 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT667553 LRAT lecithin retinol acyltransferase 2 4
MIRT667744 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668080 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT668114 GK5 glycerol kinase 5 (putative) 2 2
MIRT668501 ESYT2 extended synaptotagmin 2 2 2
MIRT668942 CNKSR3 CNKSR family member 3 2 2
MIRT670408 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671134 CD226 CD226 molecule 2 2
MIRT671919 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672287 GP2 glycoprotein 2 2 2
MIRT672427 POLR2D RNA polymerase II subunit D 2 2
MIRT672762 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672923 LRRC2 leucine rich repeat containing 2 2 2
MIRT673150 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673309 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT673560 PLA2G16 phospholipase A2 group XVI 2 2
MIRT673895 DCTN6 dynactin subunit 6 2 2
MIRT674513 PRR23A proline rich 23A 2 2
MIRT674614 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT674747 SLC16A1 solute carrier family 16 member 1 2 2
MIRT675693 PIWIL1 piwi like RNA-mediated gene silencing 1 2 2
MIRT675890 SNAP29 synaptosome associated protein 29 2 2
MIRT685271 KIAA1143 KIAA1143 2 2
MIRT686057 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT693886 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT695594 TMEM199 transmembrane protein 199 2 2
MIRT696592 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT698041 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT699907 RUNDC1 RUN domain containing 1 2 2
MIRT706608 CYB5B cytochrome b5 type B 2 2
MIRT706628 PNPT1 polyribonucleotide nucleotidyltransferase 1 2 2
MIRT706640 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT706676 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT706723 RFK riboflavin kinase 2 2
MIRT706857 MAFF MAF bZIP transcription factor F 2 2
MIRT706891 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT706958 FANCC Fanconi anemia complementation group C 2 2
MIRT706976 XPO5 exportin 5 2 2
MIRT707010 RRP36 ribosomal RNA processing 36 2 2
MIRT707028 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707068 MED29 mediator complex subunit 29 2 2
MIRT713253 ZFP30 ZFP30 zinc finger protein 2 2
MIRT719130 NR2F6 nuclear receptor subfamily 2 group F member 6 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6501 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6501 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6501-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6501-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6501-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6501-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-6501-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6501-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6501-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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