miRTarBase - #MIRT530679


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pre-miRNA Information
pre-miRNA hsa-mir-3663   
Genomic Coordinates chr10: 117167678 - 117167774
Description Homo sapiens miR-3663 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3663-5p
Sequence 21| GCUGGUCUGCGUGGUGCUCGG |41
Evidence Experimental
Experiments Northern
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111525499 10 dbSNP
rs1186183324 11 dbSNP
rs1166397684 12 dbSNP
rs1391472885 17 dbSNP
rs1461514502 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CHRNB1   
Synonyms ACHRB, CHRNB, CMS1D, CMS2A, CMS2C, SCCMS
Description cholinergic receptor nicotinic beta 1 subunit
Transcript NM_000747   
Expression
Putative miRNA Targets on CHRNB1
3'UTR of CHRNB1
(miRNA target sites are highlighted)		 
>CHRNB1|NM_000747|3'UTR
   1 AGACTGGAGGGTTGAGACCCAGGCCCCCTGCCAGTTGAAGTGAGAGTTTGGTGATACTGTCAAGCCCTATCCTTCTCTGC
  81 CTCTTAACTCCTTCACGAGGAATCTGGGCCTCTTATTTCGTTTCTGGGGACTGCATTGGACTGAGGGCTGGGTAGGCAGG
 161 TGTCTTGGACCCACCTGAAATGCAGTATCATCTGATTTACTCTTTGGGATCTTGAAGAAGCTCTTTTGGGTATCAACACC
 241 TAGGTCGCCAGTGAAATAGAACACAGAACAGGAACTAGATTATAAGCCTTATGAGGTCAAGAAATGTGACTTGGCCGGGC
 321 GCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATCACCTGAGGTCGGGAGTTTGAGACCAG
 401 CCCGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCCAGGTGTGGTGGTACATGCCTGTAATCCCAG
 481 CTACTAGGGAGGCTGAGGCAGGAGAATCACTCGAACCCGGGAGGCAGAGGTTGCAGTGAGTCAAGATCACGCCATTGCAC
 561 TCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAGTGTCTTGTTCACTGCAGCATGCCCAGTGCCACG
 641 CACAGGTGCTGACCTATAGTAAGTGCTTAACATTTGTTGAATAGGGGAAAGAAATTTCCGGAAGTAAATACAGCAATTAA
 721 TAATGTTTATAAGCTGGGCATGGTCGCTCAGGCCAGTAATCCCAGTGACTTAGGAGGCTGAGGTGGGAGGATTACTTGAA
 801 ACCCACAGTTTGAGACCAGCCTGGGCAACATAGTGAGACCCTGTCTCTAAAAAAATAAAAATAGAAATAAAGTAGTGCTT
 881 ATTGTTTGCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggCUCGU---GGUGCGUCUGGUCg 5'
            |:|||   :|:| |||:|||| 
Target 5' ctGGGCATGGTCGCTCAGGCCAGt 3'
 734 - 757 147.00 -25.80
2 
miRNA  3' ggCUCGUGGUG-CG---UCUGGUCg 5'
            ||   |||| |:   ||||||| 
Target 5' ttGAAACCCACAGTTTGAGACCAGc 3'
 796 - 820 147.00 -18.70
3 
miRNA  3' ggcUCGUGGUGCGUCUGGUCg 5'
             :| | : :| ||||||| 
Target 5' gtcGGGAGTTTG-AGACCAGc 3'
 382 - 401 141.00 -20.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
256770 19 ClinVar
325108 32 ClinVar
325109 69 ClinVar
325110 72 ClinVar
890333 80 ClinVar
890334 121 ClinVar
325111 137 ClinVar
325112 282 ClinVar
890896 288 ClinVar
890897 344 ClinVar
890898 370 ClinVar
890899 404 ClinVar
325113 434 ClinVar
890900 513 ClinVar
892131 702 ClinVar
325114 750 ClinVar
325115 756 ClinVar
892132 766 ClinVar
892133 776 ClinVar
325116 779 ClinVar
325117 844 ClinVar
COSN30175275 14 COSMIC
COSN30144397 29 COSMIC
COSN30108183 35 COSMIC
COSN9322795 36 COSMIC
COSN31485133 54 COSMIC
COSN31516667 55 COSMIC
COSN31613808 67 COSMIC
COSN18013617 69 COSMIC
COSN1201293 77 COSMIC
COSN30193038 78 COSMIC
COSN26970725 83 COSMIC
COSN1201295 90 COSMIC
COSN32069287 184 COSMIC
COSN9322796 224 COSMIC
COSN31522339 242 COSMIC
COSN16379520 292 COSMIC
COSN30237008 373 COSMIC
COSN9322797 398 COSMIC
COSN22899029 704 COSMIC
COSN22629758 886 COSMIC
rs2302764 69 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs768877353 3 dbSNP
rs1287617998 6 dbSNP
rs748542529 8 dbSNP
rs1199526444 10 dbSNP
rs1480977718 10 dbSNP
rs1253591150 13 dbSNP
rs770263810 15 dbSNP
rs1190105255 18 dbSNP
rs79747991 19 dbSNP
rs1004764077 21 dbSNP
rs762522013 24 dbSNP
rs1157368856 25 dbSNP
rs1021566770 27 dbSNP
rs1471606445 28 dbSNP
rs770407171 29 dbSNP
rs75282248 32 dbSNP
rs759202748 34 dbSNP
rs370459317 35 dbSNP
rs752487148 36 dbSNP
rs963258690 39 dbSNP
rs1224712642 40 dbSNP
rs1452095511 42 dbSNP
rs760591391 43 dbSNP
rs764059344 44 dbSNP
rs1311290164 51 dbSNP
rs1377028214 52 dbSNP
rs1333395117 61 dbSNP
rs760190833 66 dbSNP
rs2302764 69 dbSNP
rs886053405 72 dbSNP
rs1227981864 73 dbSNP
rs1031593513 75 dbSNP
rs1349068545 84 dbSNP
rs1305322173 98 dbSNP
rs1449942133 101 dbSNP
rs1349755546 111 dbSNP
rs73233980 117 dbSNP
rs1340226289 121 dbSNP
rs189934411 122 dbSNP
rs1159510117 125 dbSNP
rs987550443 127 dbSNP
rs182995220 137 dbSNP
rs964929592 143 dbSNP
rs1201231089 146 dbSNP
rs1246005002 148 dbSNP
rs547533724 159 dbSNP
rs1219503836 160 dbSNP
rs973954683 167 dbSNP
rs1268826249 170 dbSNP
rs912740834 183 dbSNP
rs1344376387 197 dbSNP
rs1199280272 200 dbSNP
rs1327330420 215 dbSNP
rs1285584219 217 dbSNP
rs749808517 219 dbSNP
rs1220133192 228 dbSNP
rs1256062314 231 dbSNP
rs1273626380 235 dbSNP
rs1433478713 235 dbSNP
rs565720830 240 dbSNP
rs945499476 242 dbSNP
rs929507535 248 dbSNP
rs1385914900 260 dbSNP
rs978254553 270 dbSNP
rs982449266 274 dbSNP
rs1424168392 277 dbSNP
rs3855924 282 dbSNP
rs938321792 283 dbSNP
rs548074838 288 dbSNP
rs894199982 289 dbSNP
rs948600692 290 dbSNP
rs1463734054 294 dbSNP
rs1055150693 295 dbSNP
rs1391525937 305 dbSNP
rs1312031387 313 dbSNP
rs1276932407 317 dbSNP
rs186256847 320 dbSNP
rs1171990426 321 dbSNP
rs1043254156 322 dbSNP
rs904447212 323 dbSNP
rs1415969562 324 dbSNP
rs369029563 333 dbSNP
rs998768072 334 dbSNP
rs537009813 344 dbSNP
rs1358419697 356 dbSNP
rs1363312463 358 dbSNP
rs1173686966 361 dbSNP
rs890485309 366 dbSNP
rs1411592653 367 dbSNP
rs552159525 370 dbSNP
rs201698552 371 dbSNP
rs1245025501 379 dbSNP
rs570897543 382 dbSNP
rs1483046776 383 dbSNP
rs965126692 385 dbSNP
rs1231143483 386 dbSNP
rs1255934538 390 dbSNP
rs973602238 394 dbSNP
rs1028196488 397 dbSNP
rs200092486 398 dbSNP
rs1274500712 404 dbSNP
rs1046884082 411 dbSNP
rs200997311 413 dbSNP
rs1339513589 423 dbSNP
rs1314228832 424 dbSNP
rs150545965 434 dbSNP
rs1377901848 437 dbSNP
rs377347549 450 dbSNP
rs1300875049 451 dbSNP
rs553467940 456 dbSNP
rs928190378 459 dbSNP
rs1307399316 462 dbSNP
rs1427731200 464 dbSNP
rs779312757 465 dbSNP
rs1165490424 466 dbSNP
rs1430969041 468 dbSNP
rs938352868 472 dbSNP
rs1411836012 474 dbSNP
rs574914826 477 dbSNP
rs1470945340 480 dbSNP
rs1179351706 484 dbSNP
rs1197471776 485 dbSNP
rs915677410 496 dbSNP
rs1203705643 497 dbSNP
rs948440482 498 dbSNP
rs1266701016 503 dbSNP
rs1156718063 506 dbSNP
rs1244804394 513 dbSNP
rs1320763067 516 dbSNP
rs190725123 519 dbSNP
rs1229832289 520 dbSNP
rs1307178507 521 dbSNP
rs376989569 530 dbSNP
rs1407928045 537 dbSNP
rs1392723080 547 dbSNP
rs925812172 551 dbSNP
rs1457564358 552 dbSNP
rs1321536547 555 dbSNP
rs996026629 555 dbSNP
rs1348170087 562 dbSNP
rs1028673790 565 dbSNP
rs934481172 571 dbSNP
rs1008652420 572 dbSNP
rs71383492 573 dbSNP
rs1052988302 582 dbSNP
rs890346904 583 dbSNP
rs557679129 587 dbSNP
rs1236122993 589 dbSNP
rs1487903948 593 dbSNP
rs1287507741 595 dbSNP
rs74419302 595 dbSNP
rs879886948 595 dbSNP
rs967109744 595 dbSNP
rs75431011 596 dbSNP
rs1039410445 597 dbSNP
rs900584842 601 dbSNP
rs1301943823 624 dbSNP
rs995371987 632 dbSNP
rs1209692352 640 dbSNP
rs925422068 641 dbSNP
rs1457967396 655 dbSNP
rs576011756 665 dbSNP
rs772514629 669 dbSNP
rs543414258 679 dbSNP
rs1388105013 681 dbSNP
rs1157424600 689 dbSNP
rs1027732568 694 dbSNP
rs775522004 700 dbSNP
rs1005037078 701 dbSNP
rs564887658 702 dbSNP
rs991041666 710 dbSNP
rs1250606114 718 dbSNP
rs1189874423 729 dbSNP
rs138576579 734 dbSNP
rs949372933 742 dbSNP
rs760758832 743 dbSNP
rs1206406121 746 dbSNP
rs540745733 747 dbSNP
rs760896819 750 dbSNP
rs907982001 755 dbSNP
rs80058486 756 dbSNP
rs184167734 758 dbSNP
rs776762809 766 dbSNP
rs1161023525 769 dbSNP
rs969743051 770 dbSNP
rs761728841 776 dbSNP
rs187784840 778 dbSNP
rs556525486 779 dbSNP
rs879131983 783 dbSNP
rs1293130889 811 dbSNP
rs1052853711 812 dbSNP
rs1172294277 819 dbSNP
rs890377476 831 dbSNP
rs530739200 832 dbSNP
rs911815747 835 dbSNP
rs1449586402 836 dbSNP
rs112055321 841 dbSNP
rs1388579773 843 dbSNP
rs886053406 844 dbSNP
rs552120595 845 dbSNP
rs554726863 849 dbSNP
rs967142169 854 dbSNP
rs1350340245 855 dbSNP
rs1256597711 877 dbSNP
rs1199604916 878 dbSNP
rs570743583 879 dbSNP
rs1229433460 888 dbSNP
rs765138462 894 dbSNP
rs1276636184 900 dbSNP
rs544629473 905 dbSNP
rs371036825 908 dbSNP
rs535047964 920 dbSNP
rs1243661646 922 dbSNP
rs1330455436 926 dbSNP
rs1265655496 932 dbSNP
rs1489206812 936 dbSNP
rs1247270172 939 dbSNP
rs1341236874 943 dbSNP
rs192223977 947 dbSNP
rs991089036 948 dbSNP
rs1202334648 957 dbSNP
rs1372766543 959 dbSNP
rs1309223093 964 dbSNP
rs568582265 965 dbSNP
rs1429657957 969 dbSNP
rs1389089276 971 dbSNP
rs1250994214 974 dbSNP
rs1165584364 983 dbSNP
rs1473581837 985 dbSNP
rs773030576 986 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 1140.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggCUCGUGGUG-CG-UCUGGucg 5'
            |:||| ||: |: |||||   
Target 5' cuGGGCAACAUAGUGAGACCcug 3'
 		5 - 27
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 1140.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggCUCGUGGUG-CG-UCUGGucg 5'
            |:||| ||: |: |||||   
Target 5' cuGGGCAACAUAGUGAGACCcug 3'
 		5 - 27
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000306071.2 | 3UTR | CAGCCUGGGCAACAUAGUGAGACCCUGUCUCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000306071.2 | 3UTR | CAGCCUGGGCAACAUAGUGAGACCCUGUCUCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
203 hsa-miR-3663-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT222528 CRCP CGRP receptor component 2 2
MIRT442432 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 6
MIRT450423 BCL2L14 BCL2 like 14 2 2
MIRT456341 RCSD1 RCSD domain containing 1 2 2
MIRT479763 CCND1 cyclin D1 2 2
MIRT487162 IFRD1 interferon related developmental regulator 1 2 8
MIRT495471 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT497193 DUSP18 dual specificity phosphatase 18 2 2
MIRT499717 PAGR1 PAXIP1 associated glutamate rich protein 1 2 10
MIRT502681 CSNK1G3 casein kinase 1 gamma 3 2 8
MIRT503641 POLR2F RNA polymerase II subunit F 2 4
MIRT510824 SBNO1 strawberry notch homolog 1 2 4
MIRT512347 ZNF665 zinc finger protein 665 2 4
MIRT512528 ATCAY ATCAY, caytaxin 2 4
MIRT513246 FBXO17 F-box protein 17 2 4
MIRT513502 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 6
MIRT516033 PTAFR platelet activating factor receptor 2 2
MIRT517669 TRIM72 tripartite motif containing 72 2 2
MIRT517691 FAM175A abraxas 1, BRCA1 A complex subunit 2 2
MIRT519524 ZNF8 zinc finger protein 8 2 2
MIRT520953 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT522074 ORAI2 ORAI calcium release-activated calcium modulator 2 2 4
MIRT525333 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT526504 POU5F1B POU class 5 homeobox 1B 2 2
MIRT527847 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT529211 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT530071 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT530639 PPIC peptidylprolyl isomerase C 2 4
MIRT530679 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT532177 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT532432 DHX33 DEAH-box helicase 33 2 2
MIRT532832 ZNF704 zinc finger protein 704 2 2
MIRT534236 SLC25A16 solute carrier family 25 member 16 2 4
MIRT535115 PLXNA2 plexin A2 2 2
MIRT535563 OMD osteomodulin 2 2
MIRT536487 KIAA1468 KIAA1468 2 2
MIRT538371 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT539931 NUCB1 nucleobindin 1 2 4
MIRT562305 GINM1 glycoprotein integral membrane 1 2 2
MIRT563280 BBS10 Bardet-Biedl syndrome 10 2 2
MIRT618205 C22orf39 chromosome 22 open reading frame 39 2 2
MIRT620113 HARBI1 harbinger transposase derived 1 2 2
MIRT621189 FAM153B family with sequence similarity 153 member B 2 2
MIRT623755 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT624059 EIF4E eukaryotic translation initiation factor 4E 2 2
MIRT625016 TMIGD2 transmembrane and immunoglobulin domain containing 2 2 2
MIRT626073 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT627875 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT629306 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT630446 IDE insulin degrading enzyme 2 2
MIRT631000 ZNF573 zinc finger protein 573 2 2
MIRT631093 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT631282 SGSM1 small G protein signaling modulator 1 2 2
MIRT631530 MYO6 myosin VI 2 2
MIRT631642 WDR91 WD repeat domain 91 2 4
MIRT631825 TMEM154 transmembrane protein 154 2 2
MIRT632778 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT633278 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT633658 SLC28A1 solute carrier family 28 member 1 2 2
MIRT634071 PLIN3 perilipin 3 2 2
MIRT634159 YME1L1 YME1 like 1 ATPase 2 2
MIRT634227 TMEM132B transmembrane protein 132B 2 2
MIRT636401 MYO5A myosin VA 2 2
MIRT638678 GCLM glutamate-cysteine ligase modifier subunit 2 2
MIRT640231 TOMM40 translocase of outer mitochondrial membrane 40 2 2
MIRT640304 PRR13 proline rich 13 2 2
MIRT641125 NPHP3 nephrocystin 3 2 2
MIRT643422 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT643700 KIAA0586 KIAA0586 2 2
MIRT644314 NFKBID NFKB inhibitor delta 2 2
MIRT644345 MPV17L MPV17 mitochondrial inner membrane protein like 2 2
MIRT645736 POLR3A RNA polymerase III subunit A 2 2
MIRT648058 TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit 2 2
MIRT649462 UBA5 ubiquitin like modifier activating enzyme 5 2 2
MIRT650009 KLB klotho beta 2 2
MIRT650567 YIPF4 Yip1 domain family member 4 2 2
MIRT652639 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT653887 SGK3 serum/glucocorticoid regulated kinase family member 3 2 2
MIRT655369 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT659116 DENND6A DENN domain containing 6A 2 2
MIRT659520 CHST3 carbohydrate sulfotransferase 3 2 2
MIRT659946 C8orf44-SGK3 C8orf44-SGK3 readthrough 2 2
MIRT661384 RHCG Rh family C glycoprotein 2 2
MIRT662910 MED18 mediator complex subunit 18 2 2
MIRT663107 NPR1 natriuretic peptide receptor 1 2 2
MIRT663759 ZNF285 zinc finger protein 285 2 2
MIRT664554 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT664611 LIMD1 LIM domains containing 1 2 2
MIRT666193 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT666794 PSMD1 proteasome 26S subunit, non-ATPase 1 2 2
MIRT668752 DDX19B DEAD-box helicase 19B 2 2
MIRT669601 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669704 AAK1 AP2 associated kinase 1 2 2
MIRT669812 STOML1 stomatin like 1 2 2
MIRT669927 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT669951 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670005 GPR156 G protein-coupled receptor 156 2 4
MIRT670051 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670301 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670390 EMP2 epithelial membrane protein 2 2 2
MIRT670457 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670486 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670568 GLTP glycolipid transfer protein 2 2
MIRT671061 KIF1B kinesin family member 1B 2 2
MIRT671085 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT671306 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT671807 WISP3 WNT1 inducible signaling pathway protein 3 2 2
MIRT671956 SPPL3 signal peptide peptidase like 3 2 2
MIRT671993 OSTF1 osteoclast stimulating factor 1 2 2
MIRT672092 WDR5B WD repeat domain 5B 2 2
MIRT672273 SHE Src homology 2 domain containing E 2 2
MIRT672447 TTPAL alpha tocopherol transfer protein like 2 2
MIRT672451 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT673652 CYCS cytochrome c, somatic 2 2
MIRT674003 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674054 ATXN3 ataxin 3 2 2
MIRT674248 NUP62 nucleoporin 62 2 2
MIRT674437 MIOX myo-inositol oxygenase 2 4
MIRT674476 BCL2L15 BCL2 like 15 2 2
MIRT675472 NUBPL nucleotide binding protein like 2 2
MIRT675667 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT675978 FAM126B family with sequence similarity 126 member B 2 2
MIRT676064 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT676120 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT676241 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT676257 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676388 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676744 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT676880 ENSA endosulfine alpha 2 2
MIRT676905 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT676922 KLHDC8A kelch domain containing 8A 2 2
MIRT676968 RNF19B ring finger protein 19B 2 2
MIRT677048 ZNF34 zinc finger protein 34 2 2
MIRT677114 SS18L1 SS18L1, nBAF chromatin remodeling complex subunit 2 2
MIRT677324 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677466 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677584 TRIM65 tripartite motif containing 65 2 2
MIRT677646 HAUS2 HAUS augmin like complex subunit 2 2 2
MIRT677736 MOB4 MOB family member 4, phocein 2 2
MIRT677813 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677830 TSPYL1 TSPY like 1 2 2
MIRT678083 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678158 ZNF724P zinc finger protein 724 2 2
MIRT678256 FXN frataxin 2 2
MIRT678326 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678419 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678588 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT678598 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT678831 PDE6A phosphodiesterase 6A 2 2
MIRT678945 MYADM myeloid associated differentiation marker 2 2
MIRT679046 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT679201 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT679205 FAM9B family with sequence similarity 9 member B 2 2
MIRT679223 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679270 POLM DNA polymerase mu 2 2
MIRT679288 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT679316 NPHP1 nephrocystin 1 2 2
MIRT679485 CYTIP cytohesin 1 interacting protein 2 2
MIRT679551 LIPG lipase G, endothelial type 2 2
MIRT679625 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT679649 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT679761 TLR6 toll like receptor 6 2 2
MIRT680124 ZNF576 zinc finger protein 576 2 2
MIRT680186 ZNF554 zinc finger protein 554 2 2
MIRT684282 CDK9 cyclin dependent kinase 9 2 2
MIRT689671 RBM23 RNA binding motif protein 23 2 2
MIRT690031 CCDC90B coiled-coil domain containing 90B 2 2
MIRT691447 CXorf36 chromosome X open reading frame 36 2 2
MIRT691547 FLYWCH2 FLYWCH family member 2 2 2
MIRT691726 LARS leucyl-tRNA synthetase 2 2
MIRT692029 ARSK arylsulfatase family member K 2 2
MIRT692635 SUSD1 sushi domain containing 1 2 2
MIRT693823 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT693864 IYD iodotyrosine deiodinase 2 2
MIRT693977 ZNF70 zinc finger protein 70 2 2
MIRT694145 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT695486 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695544 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695599 TMEM199 transmembrane protein 199 2 2
MIRT696003 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT696020 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT696039 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT696310 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT696400 CORO7 coronin 7 2 2
MIRT696595 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT698044 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT698139 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT702561 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT703018 HEATR5A HEAT repeat containing 5A 2 2
MIRT705118 C4orf29 abhydrolase domain containing 18 2 2
MIRT706303 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT706610 CYB5B cytochrome b5 type B 2 2
MIRT706729 RFK riboflavin kinase 2 2
MIRT707321 TMEM184B transmembrane protein 184B 2 2
MIRT708652 LYRM7 LYR motif containing 7 2 2
MIRT710520 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT714283 KIF1C kinesin family member 1C 2 2
MIRT720438 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT720612 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT722756 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723296 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT724380 NEK8 NIMA related kinase 8 2 2
MIRT725105 THRA thyroid hormone receptor, alpha 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3663 Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-mir-3663 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-3663 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-3663 Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-mir-3663 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-3663 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3663-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-3663-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3663-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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