miRTarBase - #MIRT530687


—
pre-miRNA Information
pre-miRNA hsa-mir-4778   
Genomic Coordinates chr2: 66358249 - 66358328
Description Homo sapiens miR-4778 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4778-3p
Sequence 51| UCUUCUUCCUUUGCAGAGUUGA |72
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs936001904 2 dbSNP
rs925922703 3 dbSNP
rs184768286 8 dbSNP
rs1249073833 10 dbSNP
rs977504360 13 dbSNP
rs192300002 18 dbSNP
Putative Targets

Gene Information
Gene Symbol C8orf46   
Synonyms -
Description chromosome 8 open reading frame 46
Transcript NM_152765   
Expression
Putative miRNA Targets on C8orf46
3'UTR of C8orf46
(miRNA target sites are highlighted)		 
>C8orf46|NM_152765|3'UTR
   1 AGGTGACCCTCTTCAAGTGCCCTGTGTTGGCCAAGGTTCCCCGGACAAGAGGAAAAACCTTCAGGATTGAAACTGAGCCA
  81 CACGCACCTCTGCTAGTAGCTGGTCCAAACCCATTATCCTCCCTCACTCATTGATTACCCTGGGATAGGGCACAGGAAAG
 161 AAATGTCCCTCGAAGGCAATATAAAACTGCCCCTTCTTAGAATTGCTAAAGCCATTGGTCTGAAAGTGACTTTGGGAGGT
 241 CATAAAGTTTGTATCTCTATCTTTAAGCAAAAAATTAAACTTTCCCAGCTCATTTTAAAGACCTCCAAGGAAGGAAAAAA
 321 GCAATTCCTCTGTCTTCCTTGTGAGTTGCTCTAAAGTGTGTGATTTTCTAGTGTAAATGGACTTTGAGGCACTTGTAAAC
 401 ACAATGGTTCTTACTGTTTCCATTACTGCATTTACTTCACCTTGACAAGGTACAATTTTCAAGGACAAAGCACTATATAT
 481 AAAGTTAGTAGTTCTAATATCCACTTGAGAGTATACTCAAGATTGATTTTCATGGCCATTTGGCATGATTGCATGAATTC
 561 TCTATTCTTTTATGTGCAGTTTTTCTATAGAAAAACATTAAAAGTTAAATGTTGACTGCTAATGTTTTCTGAAGTGGCAT
 641 AGTCTAGTGGAATCAATAATCCCTTGCTTTGGTATAATAATTTGAACTTTTGAAAGTGCTTTCTCATCCGTTATCTCTTA
 721 TCTTCACAAAACCCCTGTGGAAGAAAGCACAATTATTCCCAATCTGCAGAGGGGGAAATGGAGGCCTTCAGAGATTACAG
 801 GACCAGATACCAGGTAGTGGAACCAGACAGCAGGTCCTTAACTTCTCTCCAGTGGACTCCCTGCTTTGCCTACTCTCTAG
 881 CAACTGACTTGGGGAAGTTTTTAAATGGTGAGAGTGTGTCTCTGGGGGCAACCATTGAAAAGAAGACTCTGATATGTTGG
 961 AACAAGTAAGGGATTTGAATGAAATACACTATTATATCTTATATGTTAGCTTGAACCAGAAAAAGTTGACATTTTTGTAG
1041 GTCAAAAACAATTGAGCATCAATTTCATATGGTTCAACCTCATATATGATACTATGCTTTTCTTCTATCAGTGAAAATGT
1121 CATCATCAATTCCATTGTCAACATTAGTAGCCTTAAAACAATAACATAATAATAATGATGATAATGATACTTATAGCTAT
1201 CATCTATTAAATGCCTATGTTTCAGGCATGATACTAGGCAATTTATATATATCATCCTAATCTTTCTAAAAACTCTATTA
1281 GGTGGCCCTATCCACTTAATAGATGCCAATTCAAAGAGGTTAAATGATTAGACTAAGGCACCTAACTTATGTGAGTGTCA
1361 GGCTTCAATGCCTGTGTTAGAGCTACTCCTTCACACAAAATAGTTCAGAACATAGAGAAGGACCAAGGTTAATAAATGAT
1441 TTTCATCCCAAACACTAAACATGATTGATGGGTAGAGGCTGCCCGAAGTACTGTGTAAAGATGGAATCTGAGATAGAAGA
1521 ATGCTGTGGTCAATTAGTAATTCTTGCCCATGGAGGGATTAGTGACACATGCCTTGTATATTTGTCATCTGTGGCCTAAA
1601 CTCTGCCCCTGAAGGTTTGTTTTCTAATTCAGAGGTTTAAATTAATCTAGCCCACTTAATAAAACCAGAGATCCTATGGG
1681 AAATTTAGCCTAAGACAGTGCTGGAAATTGCCATATGTTGATACAAAGAAGTGTTTGGCCACATTACAGGTCTCAGACTC
1761 AACTGCTATGTGTGACTGCCGCTCTGTGCCTATGTCTTGCTTTTTTGCTGAGTTCCCTATTTCCATATCTCCAGGTGAAT
1841 CCATGAGAAGCGAGAGGGTGGCTGAGAGGCCTGGGCCTCTGGGATTCCACCTTGCTATCTCTGCTCTTCAACCATTGTTT
1921 TAGACTCTGAACACCAGATCCTCATATCTGAAAGTGATTTGGAGACCTGGGCATCAAGTGCTCTTTTAAGAAGGGGCTAT
2001 CCCAGAGGACTGTTCAAAAGTCTCATTCAATAGAGATGTTGGAGTCCAGAACAAAGTTAGGGAGCAAACCAGTAACCTAT
2081 GCTGGTCGTAACAGAGGATCCTACAATTACGTTTGTTTTTAAGACAGGATTTTGCTGTGTTGCCCAGACTGGTCTCAAAC
2161 TCCTGGGTTCAAGAGATCCATCCTCCCACCTCAGTCTCCTGAAAGCTGGGATGACAGGCACATGCCACCACACCTAGCTC
2241 CTTACAACCATTTATTTTAACTTATTTCATTTATAACTGGTATCTTTCATTTGTATGTGGCAGCTAGAGATTTATATAGG
2321 ATGGAAGTAATTTATTTTTAATTTAAATATTTCATGTTGAACTGTTTGCCTTGTATGGAACATTTTACTTGGCCAATTCA
2401 AATAAAAATAAAGTCAGCTTTGTTTGTGACATTCATGCACCACCATAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUUGAGACGUUUCCUUCUUcu 5'
            :| |||| :|  ||||||  
Target 5' tgGAATCTGAGATAGAAGAAtg 3'
 1502 - 1523 140.00 -10.00
2 
miRNA  3' agUUGAGACGUUUCCUUCUUcu 5'
            | | |||:   |||||||  
Target 5' aaACCCCTGT---GGAAGAAag 3'
 729 - 747 133.00 -10.60
3 
miRNA  3' aguUGAGACGUUUCCUUCUUcu 5'
             | ||||||:|||::|||  
Target 5' cccAATCTGCAGAGGGGGAAat 3'
 758 - 779 131.00 -21.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28648153 15 COSMIC
COSN4894173 20 COSMIC
COSN5274340 22 COSMIC
COSN31536270 42 COSMIC
COSN30715301 54 COSMIC
COSN30141229 80 COSMIC
COSN25541268 99 COSMIC
COSN1367254 117 COSMIC
COSN31574362 117 COSMIC
COSN31962973 137 COSMIC
COSN31488678 157 COSMIC
COSN31491144 172 COSMIC
COSN216982 191 COSMIC
COSN6359763 452 COSMIC
COSN24225576 1110 COSMIC
COSN24224795 1267 COSMIC
COSN2285618 1436 COSMIC
COSN8096758 1482 COSMIC
COSN24226366 1648 COSMIC
COSN27553417 1656 COSMIC
COSN8096759 1965 COSMIC
COSN15787648 1987 COSMIC
COSN8096760 2010 COSMIC
COSN23631899 2023 COSMIC
COSN6359764 2113 COSMIC
COSN24222377 2241 COSMIC
COSN24222378 2400 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs544246461 4 dbSNP
rs200736847 6 dbSNP
rs746606235 8 dbSNP
rs74540254 15 dbSNP
rs780707495 21 dbSNP
rs547109778 22 dbSNP
rs747645866 26 dbSNP
rs199568191 27 dbSNP
rs1350072753 28 dbSNP
rs974165916 31 dbSNP
rs1296169146 32 dbSNP
rs773258721 35 dbSNP
rs749292321 39 dbSNP
rs770841536 40 dbSNP
rs774287394 43 dbSNP
rs372087831 44 dbSNP
rs764244776 45 dbSNP
rs776731663 46 dbSNP
rs1202701299 48 dbSNP
rs761766475 50 dbSNP
rs983683600 52 dbSNP
rs17322752 58 dbSNP
rs926480416 60 dbSNP
rs1475898957 66 dbSNP
rs949990958 84 dbSNP
rs1328290545 85 dbSNP
rs980020683 87 dbSNP
rs549681041 89 dbSNP
rs569423682 93 dbSNP
rs1398601517 104 dbSNP
rs1321559339 106 dbSNP
rs1288348321 107 dbSNP
rs1235688486 111 dbSNP
rs1356110647 114 dbSNP
rs935636144 115 dbSNP
rs1390433325 117 dbSNP
rs1329194684 123 dbSNP
rs1299007098 127 dbSNP
rs939258234 134 dbSNP
rs537068155 139 dbSNP
rs891543720 140 dbSNP
rs1462960241 145 dbSNP
rs1417901749 150 dbSNP
rs945037388 159 dbSNP
rs946251023 161 dbSNP
rs1252215895 165 dbSNP
rs1177496391 166 dbSNP
rs1292144890 169 dbSNP
rs903599946 172 dbSNP
rs1051686827 173 dbSNP
rs1216047812 177 dbSNP
rs891399942 181 dbSNP
rs1336145395 191 dbSNP
rs1235091942 192 dbSNP
rs775320901 193 dbSNP
rs1007570652 197 dbSNP
rs550269778 204 dbSNP
rs1318869111 206 dbSNP
rs1307970076 214 dbSNP
rs1480214426 215 dbSNP
rs537521974 217 dbSNP
rs1386427608 218 dbSNP
rs1366571325 219 dbSNP
rs1442884288 220 dbSNP
rs557438697 220 dbSNP
rs1395101279 231 dbSNP
rs898504684 235 dbSNP
rs1009123135 240 dbSNP
rs370804349 240 dbSNP
rs1450992955 269 dbSNP
rs1019633845 270 dbSNP
rs1159311522 275 dbSNP
rs1432262011 279 dbSNP
rs1439781765 284 dbSNP
rs995506507 288 dbSNP
rs972482916 305 dbSNP
rs1247932621 307 dbSNP
rs182252216 312 dbSNP
rs951431581 322 dbSNP
rs1232743660 324 dbSNP
rs1475799990 328 dbSNP
rs187922417 331 dbSNP
rs552642677 334 dbSNP
rs1371544334 335 dbSNP
rs572737763 354 dbSNP
rs753748678 359 dbSNP
rs1386435578 360 dbSNP
rs1288978304 361 dbSNP
rs1461853121 364 dbSNP
rs939204458 387 dbSNP
rs1175185724 396 dbSNP
rs757535780 404 dbSNP
rs980434174 407 dbSNP
rs1398110674 408 dbSNP
rs1191591056 410 dbSNP
rs927175095 414 dbSNP
rs1393946998 417 dbSNP
rs935708073 431 dbSNP
rs989765917 446 dbSNP
rs1484765708 454 dbSNP
rs779216337 461 dbSNP
rs1282736103 467 dbSNP
rs913011182 468 dbSNP
rs1043784710 470 dbSNP
rs535243208 470 dbSNP
rs1225107720 478 dbSNP
rs1328093330 501 dbSNP
rs1050840551 506 dbSNP
rs891299070 508 dbSNP
rs903546173 514 dbSNP
rs1373158883 515 dbSNP
rs1314253583 521 dbSNP
rs555648680 524 dbSNP
rs1370285688 525 dbSNP
rs575407553 534 dbSNP
rs942847523 546 dbSNP
rs1049518735 550 dbSNP
rs1040400898 554 dbSNP
rs889265469 563 dbSNP
rs898743381 564 dbSNP
rs1227808225 565 dbSNP
rs995537606 575 dbSNP
rs1188865330 585 dbSNP
rs1025633537 586 dbSNP
rs1271200991 589 dbSNP
rs1341279590 595 dbSNP
rs1251809166 597 dbSNP
rs1009482564 601 dbSNP
rs544597175 605 dbSNP
rs1341677056 609 dbSNP
rs1352952913 610 dbSNP
rs887084559 611 dbSNP
rs1014101578 612 dbSNP
rs1209039042 623 dbSNP
rs1256863652 624 dbSNP
rs1025025473 625 dbSNP
rs1486069214 641 dbSNP
rs971641177 648 dbSNP
rs750681368 662 dbSNP
rs566546389 664 dbSNP
rs1326511704 669 dbSNP
rs1019160078 670 dbSNP
rs1397663330 672 dbSNP
rs898068431 676 dbSNP
rs1460362315 691 dbSNP
rs993788580 695 dbSNP
rs564368705 696 dbSNP
rs879185389 698 dbSNP
rs578061566 704 dbSNP
rs1027597561 709 dbSNP
rs1001372099 710 dbSNP
rs147832717 711 dbSNP
rs192355552 714 dbSNP
rs1212936350 728 dbSNP
rs1194279334 734 dbSNP
rs183108988 738 dbSNP
rs960534117 753 dbSNP
rs549278084 764 dbSNP
rs373798815 766 dbSNP
rs912916219 768 dbSNP
rs1277342846 770 dbSNP
rs1432443982 772 dbSNP
rs913776533 776 dbSNP
rs1336679215 780 dbSNP
rs967040449 783 dbSNP
rs924914930 786 dbSNP
rs1327226488 787 dbSNP
rs986960877 787 dbSNP
rs1456767982 792 dbSNP
rs932324596 794 dbSNP
rs1049467623 799 dbSNP
rs912323061 801 dbSNP
rs141310027 809 dbSNP
rs780206510 814 dbSNP
rs1039885279 821 dbSNP
rs1467008485 825 dbSNP
rs1361118621 826 dbSNP
rs898022820 829 dbSNP
rs994126094 834 dbSNP
rs920200481 835 dbSNP
rs1350908561 854 dbSNP
rs931573621 860 dbSNP
rs1302304863 862 dbSNP
rs887739307 869 dbSNP
rs531867031 878 dbSNP
rs552048888 887 dbSNP
rs1002166152 890 dbSNP
rs1033673147 895 dbSNP
rs1297408075 898 dbSNP
rs1047317134 909 dbSNP
rs961075511 910 dbSNP
rs570153886 915 dbSNP
rs1013696885 918 dbSNP
rs1013549370 923 dbSNP
rs1348871674 924 dbSNP
rs1172079667 925 dbSNP
rs532752510 927 dbSNP
rs747451548 930 dbSNP
rs905268129 934 dbSNP
rs966585043 939 dbSNP
rs979321320 951 dbSNP
rs1001803327 952 dbSNP
rs1034126359 957 dbSNP
rs1259057642 981 dbSNP
rs1279150976 982 dbSNP
rs1485802296 982 dbSNP
rs957176547 986 dbSNP
rs1264273869 992 dbSNP
rs1304653161 993 dbSNP
rs1214453328 997 dbSNP
rs1360453021 1006 dbSNP
rs1011459028 1011 dbSNP
rs1453025756 1027 dbSNP
rs1020122909 1029 dbSNP
rs967448842 1030 dbSNP
rs1431554758 1032 dbSNP
rs953660303 1043 dbSNP
rs1139805 1044 dbSNP
rs146976471 1047 dbSNP
rs986477733 1052 dbSNP
rs1192611765 1055 dbSNP
rs1395241674 1063 dbSNP
rs769272311 1069 dbSNP
rs963813499 1085 dbSNP
rs975137996 1088 dbSNP
rs1417285792 1091 dbSNP
rs985117703 1092 dbSNP
rs920105528 1104 dbSNP
rs7832611 1112 dbSNP
rs1256207061 1120 dbSNP
rs1047348307 1149 dbSNP
rs1454224259 1162 dbSNP
rs1486464942 1165 dbSNP
rs1036794340 1166 dbSNP
rs535647539 1175 dbSNP
rs919395694 1175 dbSNP
rs1275643754 1177 dbSNP
rs542969126 1180 dbSNP
rs1334188663 1183 dbSNP
rs1291550642 1187 dbSNP
rs949448308 1191 dbSNP
rs559394510 1195 dbSNP
rs1356316504 1196 dbSNP
rs905298410 1200 dbSNP
rs1297875206 1214 dbSNP
rs1441197269 1226 dbSNP
rs1439801110 1227 dbSNP
rs1002262652 1232 dbSNP
rs929491842 1236 dbSNP
rs1053767980 1246 dbSNP
rs1466101043 1256 dbSNP
rs892978282 1257 dbSNP
rs1049267511 1258 dbSNP
rs888019275 1258 dbSNP
rs1002447677 1273 dbSNP
rs1257765999 1283 dbSNP
rs1176333805 1317 dbSNP
rs1479828820 1320 dbSNP
rs1259210164 1336 dbSNP
rs770146972 1341 dbSNP
rs1055033819 1342 dbSNP
rs1304921670 1343 dbSNP
rs1334731143 1352 dbSNP
rs1020196363 1355 dbSNP
rs555223634 1358 dbSNP
rs1008333868 1360 dbSNP
rs1235195357 1368 dbSNP
rs188233430 1369 dbSNP
rs577745245 1381 dbSNP
rs964023552 1386 dbSNP
rs1467532606 1390 dbSNP
rs1213398891 1393 dbSNP
rs1370848913 1394 dbSNP
rs537789494 1397 dbSNP
rs1299700809 1411 dbSNP
rs1447300999 1413 dbSNP
rs751434681 1420 dbSNP
rs1254045287 1424 dbSNP
rs1021058405 1425 dbSNP
rs975169135 1426 dbSNP
rs558014618 1429 dbSNP
rs1026696618 1444 dbSNP
rs193076401 1462 dbSNP
rs966907617 1463 dbSNP
rs1416972036 1465 dbSNP
rs1000709993 1466 dbSNP
rs1468363128 1470 dbSNP
rs1406587101 1471 dbSNP
rs578089530 1482 dbSNP
rs759206423 1485 dbSNP
rs544907223 1486 dbSNP
rs1260245186 1489 dbSNP
rs985403187 1490 dbSNP
rs952897632 1493 dbSNP
rs554325973 1494 dbSNP
rs765737475 1513 dbSNP
rs965091842 1517 dbSNP
rs148012130 1525 dbSNP
rs949642790 1529 dbSNP
rs1326284456 1534 dbSNP
rs564713200 1538 dbSNP
rs796485282 1543 dbSNP
rs1443041421 1558 dbSNP
rs140756002 1560 dbSNP
rs1438847329 1565 dbSNP
rs562987133 1567 dbSNP
rs1296724584 1569 dbSNP
rs926657719 1572 dbSNP
rs372336056 1579 dbSNP
rs931097098 1591 dbSNP
rs771457689 1595 dbSNP
rs909411377 1606 dbSNP
rs1158942666 1609 dbSNP
rs1393676967 1610 dbSNP
rs938253605 1610 dbSNP
rs1309259191 1615 dbSNP
rs1333271046 1618 dbSNP
rs1434286595 1620 dbSNP
rs1055395707 1621 dbSNP
rs1443411216 1632 dbSNP
rs150088736 1633 dbSNP
rs138381785 1634 dbSNP
rs775101720 1642 dbSNP
rs1337472851 1643 dbSNP
rs1201993410 1648 dbSNP
rs1210443569 1651 dbSNP
rs1232021300 1653 dbSNP
rs1277961155 1654 dbSNP
rs565217651 1656 dbSNP
rs532780103 1661 dbSNP
rs1294839126 1667 dbSNP
rs947252739 1672 dbSNP
rs1041535696 1674 dbSNP
rs1363455676 1675 dbSNP
rs1254812369 1682 dbSNP
rs1433742993 1686 dbSNP
rs1373988116 1690 dbSNP
rs1175889015 1694 dbSNP
rs184966284 1699 dbSNP
rs1008161613 1706 dbSNP
rs1419744153 1734 dbSNP
rs1191755463 1739 dbSNP
rs764154423 1743 dbSNP
rs1264014774 1746 dbSNP
rs899500043 1747 dbSNP
rs1187444243 1749 dbSNP
rs1484795448 1765 dbSNP
rs753843176 1766 dbSNP
rs1000991388 1781 dbSNP
rs996512694 1782 dbSNP
rs1354099510 1783 dbSNP
rs1026770493 1796 dbSNP
rs1250622026 1800 dbSNP
rs763609752 1801 dbSNP
rs1308693796 1803 dbSNP
rs1369937638 1818 dbSNP
rs1278315625 1824 dbSNP
rs1413681049 1825 dbSNP
rs1353159442 1826 dbSNP
rs1443234265 1833 dbSNP
rs1032163485 1835 dbSNP
rs1396970682 1837 dbSNP
rs71515023 1848 dbSNP
rs1309889789 1851 dbSNP
rs952426712 1852 dbSNP
rs982972057 1853 dbSNP
rs375673155 1864 dbSNP
rs1425022071 1875 dbSNP
rs1006789035 1876 dbSNP
rs1015781796 1878 dbSNP
rs1019529598 1880 dbSNP
rs1259865638 1890 dbSNP
rs1188509860 1891 dbSNP
rs1414688171 1915 dbSNP
rs1249579103 1926 dbSNP
rs965380174 1928 dbSNP
rs972416020 1930 dbSNP
rs1025769926 1939 dbSNP
rs566232688 1945 dbSNP
rs1213111891 1953 dbSNP
rs1272765905 1958 dbSNP
rs1245085313 1961 dbSNP
rs1335496187 1966 dbSNP
rs982390759 1970 dbSNP
rs1327232556 1973 dbSNP
rs1393549819 1988 dbSNP
rs926826696 1994 dbSNP
rs1206225686 1996 dbSNP
rs938051785 1997 dbSNP
rs1277539666 2000 dbSNP
rs189813747 2001 dbSNP
rs1188564332 2025 dbSNP
rs915351655 2025 dbSNP
rs1259443350 2027 dbSNP
rs1362323432 2033 dbSNP
rs945484033 2039 dbSNP
rs549050847 2040 dbSNP
rs149442590 2052 dbSNP
rs1042839578 2054 dbSNP
rs1466706362 2059 dbSNP
rs903026751 2065 dbSNP
rs543386997 2070 dbSNP
rs943830488 2071 dbSNP
rs1041006684 2079 dbSNP
rs899744032 2088 dbSNP
rs996543840 2089 dbSNP
rs538021479 2095 dbSNP
rs146389699 2097 dbSNP
rs1242760689 2111 dbSNP
rs918183818 2112 dbSNP
rs949702843 2126 dbSNP
rs1439366033 2136 dbSNP
rs550249875 2143 dbSNP
rs556954298 2146 dbSNP
rs888088980 2149 dbSNP
rs1042390152 2151 dbSNP
rs1003979220 2157 dbSNP
rs1170771491 2168 dbSNP
rs1015725035 2170 dbSNP
rs1383059841 2189 dbSNP
rs970921273 2190 dbSNP
rs116593118 2196 dbSNP
rs1380701846 2197 dbSNP
rs1313567880 2198 dbSNP
rs1192876855 2199 dbSNP
rs1342731431 2201 dbSNP
rs1033968293 2214 dbSNP
rs1429275111 2216 dbSNP
rs959599096 2221 dbSNP
rs1363147691 2234 dbSNP
rs534197095 2237 dbSNP
rs989669543 2246 dbSNP
rs554164629 2251 dbSNP
rs966650928 2263 dbSNP
rs574083238 2271 dbSNP
rs978204193 2280 dbSNP
rs542795731 2282 dbSNP
rs750626250 2285 dbSNP
rs911961934 2293 dbSNP
rs1232602758 2300 dbSNP
rs1210903939 2301 dbSNP
rs1276026607 2303 dbSNP
rs879117648 2305 dbSNP
rs1324768892 2308 dbSNP
rs901085087 2315 dbSNP
rs1420563260 2321 dbSNP
rs1360887206 2331 dbSNP
rs1172757572 2344 dbSNP
rs1445172502 2355 dbSNP
rs994513145 2357 dbSNP
rs758696588 2361 dbSNP
rs1474759757 2370 dbSNP
rs1239881241 2371 dbSNP
rs1242466318 2375 dbSNP
rs375724067 2377 dbSNP
rs1190751814 2379 dbSNP
rs1209166542 2393 dbSNP
rs779966925 2411 dbSNP
rs866689717 2412 dbSNP
rs1454008706 2414 dbSNP
rs1005237526 2415 dbSNP
rs921205075 2432 dbSNP
rs1404487843 2437 dbSNP
rs932573178 2441 dbSNP
rs556605332 2446 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 254778.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aguUGAGAC-GUUU--CCUUCUUCu 5'
             |||||| :| :  |||| ||| 
Target 5' ---ACUCUGAUAUGUUGGAACAAGu 3'
 		1 - 22
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000305454.3 | 3UTR | ACUCUGAUAUGUUGGAACAAGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
169 hsa-miR-4778-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT199338 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 4
MIRT203028 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT260646 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT336468 SRP9 signal recognition particle 9 2 2
MIRT389212 SERTAD2 SERTA domain containing 2 2 2
MIRT441814 TENM1 teneurin transmembrane protein 1 2 2
MIRT444029 GREM1 gremlin 1, DAN family BMP antagonist 2 4
MIRT454171 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT469663 RABEPK Rab9 effector protein with kelch motifs 2 2
MIRT495579 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT498340 PRELID2 PRELI domain containing 2 2 2
MIRT498696 LYRM2 LYR motif containing 2 2 6
MIRT504156 OPN5 opsin 5 2 4
MIRT506321 OTUD4 OTU deubiquitinase 4 2 4
MIRT507608 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT525431 PROX2 prospero homeobox 2 2 2
MIRT526973 PAX7 paired box 7 2 2
MIRT527814 TMEM74B transmembrane protein 74B 2 2
MIRT527960 MTAP methylthioadenosine phosphorylase 2 2
MIRT528083 NOL9 nucleolar protein 9 2 2
MIRT528480 STAMBPL1 STAM binding protein like 1 2 2
MIRT528947 PNMA5 paraneoplastic Ma antigen family member 5 2 2
MIRT530687 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT531733 SLC2A9 solute carrier family 2 member 9 2 2
MIRT532445 PLGRKT plasminogen receptor with a C-terminal lysine 2 2
MIRT533331 UNK unkempt family zinc finger 2 2
MIRT534205 SLC38A9 solute carrier family 38 member 9 2 2
MIRT534322 SHISA6 shisa family member 6 2 2
MIRT535197 PLCL1 phospholipase C like 1 (inactive) 2 2
MIRT538076 DIAPH2 diaphanous related formin 2 2 2
MIRT539250 ANKRD50 ankyrin repeat domain 50 2 2
MIRT548733 CREBRF CREB3 regulatory factor 2 2
MIRT556406 LRRC8B leucine rich repeat containing 8 VRAC subunit B 2 2
MIRT559576 AP1AR adaptor related protein complex 1 associated regulatory protein 2 2
MIRT567661 ERGIC2 ERGIC and golgi 2 2 2
MIRT572750 FAM204A family with sequence similarity 204 member A 2 2
MIRT609355 ZNF664 zinc finger protein 664 2 2
MIRT611194 TMEM105 transmembrane protein 105 2 2
MIRT611545 BIRC5 baculoviral IAP repeat containing 5 2 4
MIRT611690 NODAL nodal growth differentiation factor 2 2
MIRT611810 FCRL4 Fc receptor like 4 2 2
MIRT612746 MYOCD myocardin 2 2
MIRT614177 FAM53B family with sequence similarity 53 member B 2 2
MIRT614431 TAZ tafazzin 2 2
MIRT614586 SDC1 syndecan 1 2 2
MIRT615547 TNFSF15 TNF superfamily member 15 2 2
MIRT615872 BRD3 bromodomain containing 3 2 2
MIRT615970 ASCL1 achaete-scute family bHLH transcription factor 1 2 2
MIRT616024 PRRG4 proline rich and Gla domain 4 2 4
MIRT616242 NFIC nuclear factor I C 2 2
MIRT616282 HMGB1 high mobility group box 1 2 2
MIRT616674 PRR15 proline rich 15 2 2
MIRT618302 COL4A4 collagen type IV alpha 4 chain 2 2
MIRT618657 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT618754 SLC38A5 solute carrier family 38 member 5 2 2
MIRT619505 TXLNB taxilin beta 2 2
MIRT619545 GABRG2 gamma-aminobutyric acid type A receptor gamma2 subunit 2 2
MIRT619605 MKKS McKusick-Kaufman syndrome 2 2
MIRT619804 CDC42EP4 CDC42 effector protein 4 2 2
MIRT619923 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT620442 SEMA3E semaphorin 3E 2 4
MIRT620730 CCL16 C-C motif chemokine ligand 16 2 2
MIRT625345 TAPBP TAP binding protein 2 2
MIRT627510 ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2 2
MIRT632584 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT636901 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT637873 UTP6 UTP6, small subunit processome component 2 2
MIRT639011 ABI2 abl interactor 2 2 2
MIRT639054 FPR1 formyl peptide receptor 1 2 2
MIRT639085 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639589 RGS5 regulator of G protein signaling 5 2 2
MIRT639718 NPRL3 NPR3 like, GATOR1 complex subunit 2 2
MIRT639904 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT640392 ZNF785 zinc finger protein 785 2 2
MIRT640786 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT641290 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641442 PELO pelota mRNA surveillance and ribosome rescue factor 2 2
MIRT642426 STAT3 signal transducer and activator of transcription 3 2 2
MIRT642682 KRT74 keratin 74 2 2
MIRT643362 TRIM10 tripartite motif containing 10 2 2
MIRT643982 DUSP28 dual specificity phosphatase 28 2 2
MIRT644466 ZNF747 zinc finger protein 747 2 2
MIRT644561 SPOP speckle type BTB/POZ protein 2 2
MIRT645748 FAM213A family with sequence similarity 213 member A 2 2
MIRT646737 FADS1 fatty acid desaturase 1 2 2
MIRT647446 SIX6 SIX homeobox 6 2 2
MIRT648317 SCNN1G sodium channel epithelial 1 gamma subunit 2 2
MIRT649327 POLG DNA polymerase gamma, catalytic subunit 2 2
MIRT649453 WDR70 WD repeat domain 70 2 2
MIRT650066 CCDC134 coiled-coil domain containing 134 2 2
MIRT650156 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT650317 TMX4 thioredoxin related transmembrane protein 4 2 2
MIRT650429 BBS9 Bardet-Biedl syndrome 9 2 2
MIRT651325 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651843 USP13 ubiquitin specific peptidase 13 2 2
MIRT652532 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT652816 TARDBP TAR DNA binding protein 2 2
MIRT652971 SUN2 Sad1 and UNC84 domain containing 2 2 2
MIRT653466 SLC5A12 solute carrier family 5 member 12 2 4
MIRT653568 SLC35B3 solute carrier family 35 member B3 2 2
MIRT655678 NUMBL NUMB like, endocytic adaptor protein 2 2
MIRT656785 KPNA4 karyopherin subunit alpha 4 2 2
MIRT656798 KNTC1 kinetochore associated 1 2 2
MIRT656988 KDM5A lysine demethylase 5A 2 2
MIRT657292 HOXB5 homeobox B5 2 2
MIRT657497 HBEGF heparin binding EGF like growth factor 2 4
MIRT658012 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT658146 STXBP2 syntaxin binding protein 2 2 2
MIRT658259 FAXC failed axon connections homolog 2 2
MIRT659051 DGKH diacylglycerol kinase eta 2 2
MIRT659171 DCTN3 dynactin subunit 3 2 2
MIRT659936 CACHD1 cache domain containing 1 2 2
MIRT660079 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT660167 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660292 BICC1 BicC family RNA binding protein 1 2 2
MIRT660317 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT660340 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT660447 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 2 2
MIRT661634 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662438 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT664202 TBCA tubulin folding cofactor A 2 2
MIRT666436 SH2B3 SH2B adaptor protein 3 2 2
MIRT666666 RBM47 RNA binding motif protein 47 2 4
MIRT669253 C4orf36 chromosome 4 open reading frame 36 2 2
MIRT669502 ARL3 ADP ribosylation factor like GTPase 3 2 2
MIRT693912 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT700435 PURB purine rich element binding protein B 2 2
MIRT702857 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT708857 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709030 KBTBD13 kelch repeat and BTB domain containing 13 2 2
MIRT709609 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT709810 AR androgen receptor 2 2
MIRT709872 A1CF APOBEC1 complementation factor 2 2
MIRT710208 ENAH ENAH, actin regulator 2 2
MIRT710964 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711173 EMCN endomucin 2 2
MIRT711219 RETSAT retinol saturase 2 2
MIRT711345 FMNL2 formin like 2 2 2
MIRT711441 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT711631 PEBP1 phosphatidylethanolamine binding protein 1 2 2
MIRT711823 MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2 2
MIRT712164 SURF4 surfeit 4 2 2
MIRT712632 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713692 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT714906 CHMP3 charged multivesicular body protein 3 2 2
MIRT715161 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT715430 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT715660 ZBTB25 zinc finger and BTB domain containing 25 2 2
MIRT715968 FADS3 fatty acid desaturase 3 2 2
MIRT716203 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716234 SRSF12 serine and arginine rich splicing factor 12 2 2
MIRT716251 PALM2 paralemmin 2 2 2
MIRT716375 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT716490 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT716744 APOL6 apolipoprotein L6 2 2
MIRT717624 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2 2
MIRT718480 TMEM151A transmembrane protein 151A 2 2
MIRT718805 PRKCB protein kinase C beta 2 2
MIRT719276 SETD7 SET domain containing lysine methyltransferase 7 2 2
MIRT719432 NPTX2 neuronal pentraxin 2 2 2
MIRT721011 ZNF619 zinc finger protein 619 2 2
MIRT721819 HEATR5A HEAT repeat containing 5A 2 2
MIRT721997 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT723143 METTL24 methyltransferase like 24 2 2
MIRT723213 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT723427 MC2R melanocortin 2 receptor 2 2
MIRT723436 ADI1 acireductone dioxygenase 1 2 2
MIRT723542 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT724474 MMD monocyte to macrophage differentiation associated 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4778-3p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-4778-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

Error report submission