pre-miRNA Information
pre-miRNA hsa-mir-3180-1   
Genomic Coordinates chr16: 14911220 - 14911313
Description Homo sapiens miR-3180-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-3180-2   
Genomic Coordinates chr16: 16309879 - 16309966
Description Homo sapiens miR-3180-2 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-3180-3   
Genomic Coordinates chr16: 18402178 - 18402271
Description Homo sapiens miR-3180-3 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3180-3p
Sequence 62| UGGGGCGGAGCUUCCGGAGGCC |83
Evidence Experimental
Experiments Illumina
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SIGLEC12   
Synonyms S2V, SIGLECL1, SLG, Siglec-XII
Description sialic acid binding Ig like lectin 12 (gene/pseudogene)
Transcript NM_033329   
Other Transcripts NM_053003   
Expression
Putative miRNA Targets on SIGLEC12
3'UTR of SIGLEC12
(miRNA target sites are highlighted)
>SIGLEC12|NM_033329|3'UTR
   1 GAAACTGCAGAGACTCAGGCCTGTTTGAGGGCTCACGACCCCTGCAGCAAAGAAGCCCGAGACTGATTCCTTTAGAATTA
  81 ACAGCCCTCCATGCTGTGCAACAGGACATCAGAACTTATTCCTCTTGTCAAACTGAAAATGCGTGCCTGATGACCAAACT
 161 CTCCCTTTCTCCATCCAATCGGTCCACACTCCCCGCCCCCGGCCTCTGGTACCCACCATTCTCTTCTCTACTTCTCTGAG
 241 GTCGACTATTTTAGGTTCCAAATATAGTGAGATCGTAGAGTGTTTGTCTCTCTGTACCTGGCTTATTTCACTCAACATAA
 321 TGTTCTCTAGGTTCATCCGTGTTGTTCCAAATAACAGAATAATGTATTGAATATTTCAAAATGGCTAAAAGAGAGGAGTT
 401 TAAATGTTGTCACC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ccggAGGCCUUCGAGGCGGGGu 5'
              |||  |  | ||||||| 
Target 5' tcggTCCACACTCCCCGCCCCc 3'
179 - 200 150.00 -18.51
2
miRNA  3' ccGGAGGCCUUCGA--GGCGGGGu 5'
            |||:: ||| :|  | ||||: 
Target 5' ttCCTTTAGAA-TTAACAGCCCTc 3'
67 - 89 109.00 -13.20
3
miRNA  3' ccggAGGCCUUCGAG-GCGGGGu 5'
              |::| ::|||| || ||| 
Target 5' cctgTTTGAGGGCTCACGACCCc 3'
20 - 42 102.00 -21.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30171916 22 COSMIC
COSN31503579 27 COSMIC
COSN31485952 32 COSMIC
COSN22056396 37 COSMIC
COSN30165789 43 COSMIC
COSN19748139 44 COSMIC
COSN13824151 58 COSMIC
COSN30146724 58 COSMIC
COSN30108609 59 COSMIC
COSN31505585 61 COSMIC
COSN30115257 81 COSMIC
COSN28818808 82 COSMIC
COSN31492008 83 COSMIC
COSN31611602 146 COSMIC
COSN5761675 152 COSMIC
COSN31525725 161 COSMIC
COSN31599290 222 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1363886312 1 dbSNP
rs751363953 4 dbSNP
rs1383627843 7 dbSNP
rs1336895451 11 dbSNP
rs1196623962 14 dbSNP
rs900841380 14 dbSNP
rs766361523 17 dbSNP
rs762850612 19 dbSNP
rs773317591 23 dbSNP
rs377400151 25 dbSNP
rs1205997416 32 dbSNP
rs761901144 33 dbSNP
rs1448918086 35 dbSNP
rs776724841 36 dbSNP
rs768922483 37 dbSNP
rs747394312 38 dbSNP
rs747411180 39 dbSNP
rs372858213 41 dbSNP
rs16982735 44 dbSNP
rs1169084036 60 dbSNP
rs758126474 65 dbSNP
rs1410663324 66 dbSNP
rs527502414 69 dbSNP
rs926075695 70 dbSNP
rs915323578 73 dbSNP
rs1313283758 74 dbSNP
rs778548115 76 dbSNP
rs16982733 82 dbSNP
rs1277560941 84 dbSNP
rs922858819 87 dbSNP
rs1215861981 89 dbSNP
rs7256838 97 dbSNP
rs1465958815 106 dbSNP
rs917276078 110 dbSNP
rs977007914 112 dbSNP
rs961857830 119 dbSNP
rs1015793276 125 dbSNP
rs1486897585 130 dbSNP
rs1191941171 133 dbSNP
rs984678508 135 dbSNP
rs1476009291 142 dbSNP
rs952535190 142 dbSNP
rs541991188 143 dbSNP
rs28756785 149 dbSNP
rs1174420061 151 dbSNP
rs1377495737 153 dbSNP
rs1397970614 159 dbSNP
rs1012598318 164 dbSNP
rs895446382 165 dbSNP
rs562500065 168 dbSNP
rs1035618069 171 dbSNP
rs998809524 181 dbSNP
rs903078917 189 dbSNP
rs62116166 191 dbSNP
rs1200879950 192 dbSNP
rs1272590143 193 dbSNP
rs570093646 194 dbSNP
rs1261179544 196 dbSNP
rs1282092227 199 dbSNP
rs1351022676 201 dbSNP
rs893900501 204 dbSNP
rs1214960223 211 dbSNP
rs1219887322 214 dbSNP
rs1317976707 216 dbSNP
rs1195881544 220 dbSNP
rs1049760041 223 dbSNP
rs1277066511 229 dbSNP
rs1245057907 232 dbSNP
rs558999579 233 dbSNP
rs1397746774 236 dbSNP
rs965386367 243 dbSNP
rs558458219 244 dbSNP
rs1341956842 247 dbSNP
rs1009878369 249 dbSNP
rs1335208067 250 dbSNP
rs932673414 255 dbSNP
rs540914831 257 dbSNP
rs1395814573 263 dbSNP
rs533853116 264 dbSNP
rs922577113 272 dbSNP
rs1321589842 275 dbSNP
rs1400641620 286 dbSNP
rs977145348 297 dbSNP
rs566404587 301 dbSNP
rs1054022343 305 dbSNP
rs1000622458 307 dbSNP
rs1466648206 321 dbSNP
rs1260517096 322 dbSNP
rs80339130 326 dbSNP
rs1168700638 338 dbSNP
rs766525501 339 dbSNP
rs536383730 343 dbSNP
rs984341545 345 dbSNP
rs569026929 351 dbSNP
rs952825169 353 dbSNP
rs143214995 355 dbSNP
rs538659030 384 dbSNP
rs1471073565 396 dbSNP
rs1238280086 399 dbSNP
rs1161220793 405 dbSNP
rs1389976769 410 dbSNP
rs1461859024 411 dbSNP
rs1187907688 413 dbSNP
rs1221862994 414 dbSNP
rs1397426933 415 dbSNP
rs72258649 415 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 89858.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ccggaggccuucGAGGCGGGGu 5'
                      | ||||||| 
Target 5' ----------cuCCCCGCCCCc 3'
1 - 12
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000291707.3 | 3UTR | CUCCCCGCCCCCGGCCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
66 hsa-miR-3180-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT133792 SKI SKI proto-oncogene 2 2
MIRT146658 MINK1 misshapen like kinase 1 2 4
MIRT441337 C19orf26 CACN beta subunit associated regulatory protein 2 4
MIRT449088 XPO6 exportin 6 2 2
MIRT464967 TULP1 tubby like protein 1 2 6
MIRT471706 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT473252 MIDN midnolin 2 2
MIRT483494 STMN3 stathmin 3 2 4
MIRT483726 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT485684 CCDC64 BICD family like cargo adaptor 1 2 4
MIRT486046 WSCD1 WSC domain containing 1 2 4
MIRT486522 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486779 SESTD1 SEC14 and spectrin domain containing 1 2 4
MIRT486852 DPF1 double PHD fingers 1 2 2
MIRT487035 C10orf55 chromosome 10 open reading frame 55 2 2
MIRT487082 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT487284 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 4
MIRT487992 RXRB retinoid X receptor beta 2 2
MIRT488101 POU3F1 POU class 3 homeobox 1 2 2
MIRT488547 POU3F3 POU class 3 homeobox 3 2 8
MIRT488582 ST7L suppression of tumorigenicity 7 like 2 2
MIRT488757 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489217 ASCL2 achaete-scute family bHLH transcription factor 2 2 4
MIRT489350 SYNGR1 synaptogyrin 1 2 4
MIRT489385 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489459 MSC musculin 2 2
MIRT489469 SLITRK5 SLIT and NTRK like family member 5 2 2
MIRT489749 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490244 MFI2 melanotransferrin 2 2
MIRT490423 VPS51 VPS51, GARP complex subunit 2 4
MIRT490644 FEM1A fem-1 homolog A 2 2
MIRT491977 UNK unkempt family zinc finger 2 2
MIRT492469 RASD1 ras related dexamethasone induced 1 2 4
MIRT492837 NRGN neurogranin 2 2
MIRT492956 NEUROD2 neuronal differentiation 2 2 2
MIRT493002 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT493430 KCNK3 potassium two pore domain channel subfamily K member 3 2 2
MIRT493709 H2AFX H2A histone family member X 2 6
MIRT493886 FAM43A family with sequence similarity 43 member A 2 4
MIRT493955 ENG endoglin 2 2
MIRT500168 MSI1 musashi RNA binding protein 1 2 2
MIRT500196 MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2 4
MIRT500366 ZNF385A zinc finger protein 385A 2 2
MIRT501159 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501698 PCGF3 polycomb group ring finger 3 2 6
MIRT512173 CASP16 caspase 16, pseudogene 2 6
MIRT512237 ATG2A autophagy related 2A 2 6
MIRT512879 PITX3 paired like homeodomain 3 2 2
MIRT531184 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT548362 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT569093 FSCN1 fascin actin-bundling protein 1 2 2
MIRT574133 MARVELD1 MARVEL domain containing 1 2 2
MIRT635542 LEPROTL1 leptin receptor overlapping transcript like 1 2 2
MIRT654098 RSBN1L round spermatid basic protein 1 like 2 2
MIRT664919 BHMT2 betaine--homocysteine S-methyltransferase 2 2 2
MIRT669843 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT670502 LYRM4 LYR motif containing 4 2 2
MIRT670526 SLC9A7 solute carrier family 9 member A7 2 2
MIRT670550 SHISA2 shisa family member 2 2 2
MIRT671031 PCDHB2 protocadherin beta 2 2 2
MIRT695219 SCAMP3 secretory carrier membrane protein 3 2 2
MIRT700129 RNF144B ring finger protein 144B 2 2
MIRT709280 MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT712750 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT720753 FAM193A family with sequence similarity 193 member A 2 2
MIRT724920 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3180 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3180 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3180 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3180 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3180 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3180 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3180 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-3180 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (MGC803)
hsa-miR-3180 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-3180 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-3180 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-3180 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3180 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-3180 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3180-3p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3180-3p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3180-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3180-3p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3180-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3180-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (MGC803)
hsa-miR-3180-3p Cisplatin 5460033 NSC119875 approved resistant Low Gastric Cancer cell line (MGC-803)
hsa-miR-3180-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-3180-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-3180-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3180-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-3180-3p Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-3180-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-3180-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission