pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol SIGLEC12   
Synonyms S2V, SIGLECL1, SLG, Siglec-XII
Description sialic acid binding Ig like lectin 12 (gene/pseudogene)
Transcript NM_033329   
Other Transcripts NM_053003   
Expression
Putative miRNA Targets on SIGLEC12
3'UTR of SIGLEC12
(miRNA target sites are highlighted)
>SIGLEC12|NM_033329|3'UTR
   1 GAAACTGCAGAGACTCAGGCCTGTTTGAGGGCTCACGACCCCTGCAGCAAAGAAGCCCGAGACTGATTCCTTTAGAATTA
  81 ACAGCCCTCCATGCTGTGCAACAGGACATCAGAACTTATTCCTCTTGTCAAACTGAAAATGCGTGCCTGATGACCAAACT
 161 CTCCCTTTCTCCATCCAATCGGTCCACACTCCCCGCCCCCGGCCTCTGGTACCCACCATTCTCTTCTCTACTTCTCTGAG
 241 GTCGACTATTTTAGGTTCCAAATATAGTGAGATCGTAGAGTGTTTGTCTCTCTGTACCTGGCTTATTTCACTCAACATAA
 321 TGTTCTCTAGGTTCATCCGTGTTGTTCCAAATAACAGAATAATGTATTGAATATTTCAAAATGGCTAAAAGAGAGGAGTT
 401 TAAATGTTGTCACC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgUCGGU---CGAGAUG---GGGGCGGu 5'
            | |||   | || ||   ||||||| 
Target 5' ccATCCAATCGGTCCACACTCCCCGCCc 3'
171 - 198 152.00 -21.00
2
miRNA  3' cgucggUCGA--GAUGGGGGCGgu 5'
                :|||  | |||||:||  
Target 5' tttgagGGCTCACGACCCCTGCag 3'
24 - 47 122.00 -20.80
3
miRNA  3' cgucgGUCGAGAUGGGGGCGGu 5'
               |||| ||  || :||: 
Target 5' attaaCAGCCCT--CCATGCTg 3'
77 - 96 93.00 -12.71
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30171916 22 COSMIC
COSN31503579 27 COSMIC
COSN31485952 32 COSMIC
COSN22056396 37 COSMIC
COSN30165789 43 COSMIC
COSN19748139 44 COSMIC
COSN13824151 58 COSMIC
COSN30146724 58 COSMIC
COSN30108609 59 COSMIC
COSN31505585 61 COSMIC
COSN30115257 81 COSMIC
COSN28818808 82 COSMIC
COSN31492008 83 COSMIC
COSN31611602 146 COSMIC
COSN5761675 152 COSMIC
COSN31525725 161 COSMIC
COSN31599290 222 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1363886312 1 dbSNP
rs751363953 4 dbSNP
rs1383627843 7 dbSNP
rs1336895451 11 dbSNP
rs1196623962 14 dbSNP
rs900841380 14 dbSNP
rs766361523 17 dbSNP
rs762850612 19 dbSNP
rs773317591 23 dbSNP
rs377400151 25 dbSNP
rs1205997416 32 dbSNP
rs761901144 33 dbSNP
rs1448918086 35 dbSNP
rs776724841 36 dbSNP
rs768922483 37 dbSNP
rs747394312 38 dbSNP
rs747411180 39 dbSNP
rs372858213 41 dbSNP
rs16982735 44 dbSNP
rs1169084036 60 dbSNP
rs758126474 65 dbSNP
rs1410663324 66 dbSNP
rs527502414 69 dbSNP
rs926075695 70 dbSNP
rs915323578 73 dbSNP
rs1313283758 74 dbSNP
rs778548115 76 dbSNP
rs16982733 82 dbSNP
rs1277560941 84 dbSNP
rs922858819 87 dbSNP
rs1215861981 89 dbSNP
rs7256838 97 dbSNP
rs1465958815 106 dbSNP
rs917276078 110 dbSNP
rs977007914 112 dbSNP
rs961857830 119 dbSNP
rs1015793276 125 dbSNP
rs1486897585 130 dbSNP
rs1191941171 133 dbSNP
rs984678508 135 dbSNP
rs1476009291 142 dbSNP
rs952535190 142 dbSNP
rs541991188 143 dbSNP
rs28756785 149 dbSNP
rs1174420061 151 dbSNP
rs1377495737 153 dbSNP
rs1397970614 159 dbSNP
rs1012598318 164 dbSNP
rs895446382 165 dbSNP
rs562500065 168 dbSNP
rs1035618069 171 dbSNP
rs998809524 181 dbSNP
rs903078917 189 dbSNP
rs62116166 191 dbSNP
rs1200879950 192 dbSNP
rs1272590143 193 dbSNP
rs570093646 194 dbSNP
rs1261179544 196 dbSNP
rs1282092227 199 dbSNP
rs1351022676 201 dbSNP
rs893900501 204 dbSNP
rs1214960223 211 dbSNP
rs1219887322 214 dbSNP
rs1317976707 216 dbSNP
rs1195881544 220 dbSNP
rs1049760041 223 dbSNP
rs1277066511 229 dbSNP
rs1245057907 232 dbSNP
rs558999579 233 dbSNP
rs1397746774 236 dbSNP
rs965386367 243 dbSNP
rs558458219 244 dbSNP
rs1341956842 247 dbSNP
rs1009878369 249 dbSNP
rs1335208067 250 dbSNP
rs932673414 255 dbSNP
rs540914831 257 dbSNP
rs1395814573 263 dbSNP
rs533853116 264 dbSNP
rs922577113 272 dbSNP
rs1321589842 275 dbSNP
rs1400641620 286 dbSNP
rs977145348 297 dbSNP
rs566404587 301 dbSNP
rs1054022343 305 dbSNP
rs1000622458 307 dbSNP
rs1466648206 321 dbSNP
rs1260517096 322 dbSNP
rs80339130 326 dbSNP
rs1168700638 338 dbSNP
rs766525501 339 dbSNP
rs536383730 343 dbSNP
rs984341545 345 dbSNP
rs569026929 351 dbSNP
rs952825169 353 dbSNP
rs143214995 355 dbSNP
rs538659030 384 dbSNP
rs1471073565 396 dbSNP
rs1238280086 399 dbSNP
rs1161220793 405 dbSNP
rs1389976769 410 dbSNP
rs1461859024 411 dbSNP
rs1187907688 413 dbSNP
rs1221862994 414 dbSNP
rs1397426933 415 dbSNP
rs72258649 415 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 89858.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgucggucgagauGGGGGCGGu 5'
                       :||||||| 
Target 5' ------------cUCCCCGCCc 3'
1 - 10
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000291707.3 | 3UTR | CUCCCCGCCCCCGGCCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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