pre-miRNA Information
pre-miRNA hsa-mir-4307   
Genomic Coordinates chr14: 26908642 - 26908725
Description Homo sapiens miR-4307 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4307
Sequence 56| AAUGUUUUUUCCUGUUUCC |74
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1056441032 1 dbSNP
rs776987575 3 dbSNP
rs948027524 8 dbSNP
rs930210474 12 dbSNP
rs191460273 13 dbSNP
rs538831777 14 dbSNP
rs1158802910 15 dbSNP
rs1047679599 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ILDR1   
Synonyms DFNB42, ILDR1alpha, ILDR1alpha', ILDR1beta
Description immunoglobulin like domain containing receptor 1
Transcript NM_175924   
Expression
Putative miRNA Targets on ILDR1
3'UTR of ILDR1
(miRNA target sites are highlighted)
>ILDR1|NM_175924|3'UTR
   1 TCACCAAGCACAGCACAACTTCTGTGGCTACTTCTCGGCTCCTGTGTGTCATCAGCATCACCTAGGTTTCCAGCTGACTT
  81 GGGAACTGCAAGTCTGAGTCTAACAGTTTTTGGCTTAGATTCTGAGAATCAAATAGAAGAATTTTAAATACAAGAGTTTG
 161 AGATTGGGTATAGTGGCTCACACCTGTAATCACAGCACTTTGGGAGGCTAAGAATCACTTGAGACTAGGAGTTCAAGATC
 241 AGCCTGGGAAACATAGTGAGACCCCGTCTCTACAAAAAATATAAAAATTAGTTAGGTGTGGTGGCATGCACTTGTAGTCC
 321 CAGCTACTCAAGAGGCTGAGGCAGAAGGATCCCTTGAGCCCAGGAGTGCAAGGCTGCAATGAGCCAGGATCCCATGATCA
 401 CACATCTGTATTCCAGCCTGGGCAATAGAGCAAGTCCCCATTACTAAAAAACCCAAAAGGCCAAAAAACAAAAAAGTTAG
 481 AGTTCGAGGAATTACCAACTGTAGTTTTAGCCTTGGTTCATGCTCTCTTGCATATTTATATAATCTCTGACTTGTAATGG
 561 ACCCTGACTGGAATGTGATCCCTCAGGAACTTAGTAGCCTGAGTCTTTCAGTAGACTACACTGCCCAGAACCCTGGCCAT
 641 TCTCAAAATGAGAACTTGGGAATGTTTAAGAAGAAATCAAACATGTTTCAGGAAAAGGAAATCTATGGAGTATTATAGGG
 721 ACATTCCCATGGGAATGTATCTTCCTCCATGGCATGTCTTGAGGGTCCTTTCTTGTTAGGAGTTTATCCTGCCAGCCCAT
 801 AAATGGACTATTTATTGTAAGTGTAGAAAATCACAGAGAAGCAGTTTTGCACCAGCCTTATTCCTGTGCCTTGTTTTCCT
 881 CTTGCTCTTTTTTTACCTGTATATCTAATTTATATTTTCATATATATTGTGTATTGATTGAAGTCACTTTAAATCCTTCT
 961 TGGGAATGACACAGTATATAAATAAGGAAGAAAGAAAACATGCCAAGCTGAGCATGCTGCTCCAAATAAATATCTGCTTT
1041 CCTAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ccUUUG-UCCUU-----UUUUGUAa 5'
            |||: |||||     ||||||| 
Target 5' atAAATAAGGAAGAAAGAAAACATg 3'
978 - 1002 157.00 -9.50
2
miRNA  3' ccuUUGUCC--UUUUUUGUaa 5'
             || |||  ||||||||  
Target 5' cccAAAAGGCCAAAAAACAaa 3'
452 - 472 142.00 -5.60
3
miRNA  3' ccUUUGUC--CUUUUUUGUAa 5'
            :| |||   :::|||||| 
Target 5' aaGATCAGCCTGGGAAACATa 3'
235 - 255 131.00 -5.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
667248 11 ClinVar
1203287 266 ClinVar
COSN31482179 36 COSMIC
COSN30507104 42 COSMIC
COSN31511695 66 COSMIC
COSN30450884 70 COSMIC
COSN30453107 83 COSMIC
COSN30155597 94 COSMIC
COSN30451144 106 COSMIC
COSN31530545 107 COSMIC
COSN30167858 139 COSMIC
COSN1083322 142 COSMIC
COSN26494605 728 COSMIC
COSN9234277 994 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1191276930 6 dbSNP
rs775202902 11 dbSNP
rs150481354 15 dbSNP
rs1478259133 16 dbSNP
rs1239773407 17 dbSNP
rs372428576 19 dbSNP
rs776792036 20 dbSNP
rs1330769400 24 dbSNP
rs1465610620 25 dbSNP
rs1285978544 26 dbSNP
rs771356103 31 dbSNP
rs747424761 37 dbSNP
rs894413796 41 dbSNP
rs1398494643 52 dbSNP
rs999250175 53 dbSNP
rs202226862 55 dbSNP
rs1341571953 60 dbSNP
rs1218845091 61 dbSNP
rs1183120795 71 dbSNP
rs1442824983 72 dbSNP
rs1324737190 79 dbSNP
rs867664610 83 dbSNP
rs201749129 91 dbSNP
rs778320546 92 dbSNP
rs185522579 94 dbSNP
rs748223411 99 dbSNP
rs755137709 105 dbSNP
rs903932637 106 dbSNP
rs754067165 119 dbSNP
rs767179327 128 dbSNP
rs1378159683 130 dbSNP
rs757100881 131 dbSNP
rs754309930 132 dbSNP
rs141335434 133 dbSNP
rs1196029831 134 dbSNP
rs763038125 136 dbSNP
rs1466013297 138 dbSNP
rs1037619352 148 dbSNP
rs775080019 154 dbSNP
rs1207588772 167 dbSNP
rs759223170 170 dbSNP
rs941380433 173 dbSNP
rs1418383192 181 dbSNP
rs1275973261 187 dbSNP
rs571262745 190 dbSNP
rs1047474505 191 dbSNP
rs1329848609 192 dbSNP
rs930052001 193 dbSNP
rs1290221778 195 dbSNP
rs1365093984 196 dbSNP
rs776379104 197 dbSNP
rs922641725 206 dbSNP
rs976240063 209 dbSNP
rs753549007 212 dbSNP
rs550947393 216 dbSNP
rs1488460646 219 dbSNP
rs1218548577 237 dbSNP
rs910836218 243 dbSNP
rs964199018 244 dbSNP
rs911492468 254 dbSNP
rs1269538361 257 dbSNP
rs1437977474 262 dbSNP
rs1158515519 263 dbSNP
rs1381504068 265 dbSNP
rs181628071 266 dbSNP
rs371813355 266 dbSNP
rs549594681 266 dbSNP
rs565610957 268 dbSNP
rs764562889 278 dbSNP
rs1435294005 280 dbSNP
rs1299736060 291 dbSNP
rs1372459991 292 dbSNP
rs1443952115 296 dbSNP
rs1462286273 307 dbSNP
rs761032107 309 dbSNP
rs1371448050 311 dbSNP
rs1163128819 312 dbSNP
rs1308379564 312 dbSNP
rs1354363256 314 dbSNP
rs951787435 329 dbSNP
rs373788728 333 dbSNP
rs138335629 361 dbSNP
rs189041551 363 dbSNP
rs1419074136 368 dbSNP
rs1248688619 373 dbSNP
rs1249020225 376 dbSNP
rs999114876 377 dbSNP
rs1178141531 383 dbSNP
rs1238911737 384 dbSNP
rs1442069056 386 dbSNP
rs970455560 394 dbSNP
rs1024679873 396 dbSNP
rs1406326983 399 dbSNP
rs563334520 404 dbSNP
rs1164964406 407 dbSNP
rs1396248077 408 dbSNP
rs1012071018 426 dbSNP
rs772444510 445 dbSNP
rs1330049778 452 dbSNP
rs775889751 452 dbSNP
rs768023200 454 dbSNP
rs1444277796 458 dbSNP
rs1403730 460 dbSNP
rs1290615496 461 dbSNP
rs1403729 462 dbSNP
rs574405506 465 dbSNP
rs1219732238 469 dbSNP
rs1037912911 470 dbSNP
rs1006149312 471 dbSNP
rs759586255 475 dbSNP
rs1316262003 479 dbSNP
rs1024124235 485 dbSNP
rs530892554 486 dbSNP
rs1439704350 488 dbSNP
rs1208561864 490 dbSNP
rs958864459 501 dbSNP
rs1034308459 511 dbSNP
rs1237694203 513 dbSNP
rs1315108357 514 dbSNP
rs1000523178 517 dbSNP
rs1476620909 520 dbSNP
rs565305925 521 dbSNP
rs1400384732 524 dbSNP
rs1047095709 530 dbSNP
rs1332058363 531 dbSNP
rs929957411 532 dbSNP
rs1391790004 533 dbSNP
rs1043721475 534 dbSNP
rs746000667 536 dbSNP
rs1009583474 540 dbSNP
rs892575339 545 dbSNP
rs145679236 552 dbSNP
rs1294878015 559 dbSNP
rs1338228093 574 dbSNP
rs1302797123 591 dbSNP
rs1279087545 602 dbSNP
rs774388190 603 dbSNP
rs1217566546 619 dbSNP
rs1278484322 623 dbSNP
rs771213886 625 dbSNP
rs1403268325 627 dbSNP
rs1213697339 634 dbSNP
rs1040509110 639 dbSNP
rs911412928 644 dbSNP
rs1163970934 649 dbSNP
rs990026660 651 dbSNP
rs1453114884 655 dbSNP
rs958322828 658 dbSNP
rs924150893 662 dbSNP
rs1423917477 664 dbSNP
rs1414957949 684 dbSNP
rs1362606812 687 dbSNP
rs1161858710 693 dbSNP
rs1420071144 697 dbSNP
rs749499621 703 dbSNP
rs944929814 706 dbSNP
rs970362185 707 dbSNP
rs1024710777 712 dbSNP
rs910794198 713 dbSNP
rs1050662412 716 dbSNP
rs1231384023 716 dbSNP
rs1345871572 717 dbSNP
rs1237136185 720 dbSNP
rs1490757194 726 dbSNP
rs930901682 727 dbSNP
rs920232907 732 dbSNP
rs1016104679 735 dbSNP
rs1204080120 739 dbSNP
rs547429137 753 dbSNP
rs1448350483 758 dbSNP
rs1262445728 767 dbSNP
rs1245624663 778 dbSNP
rs1454338890 778 dbSNP
rs886396639 782 dbSNP
rs1378433220 786 dbSNP
rs1418819195 795 dbSNP
rs1158989472 803 dbSNP
rs573592263 817 dbSNP
rs773364992 822 dbSNP
rs867131362 832 dbSNP
rs1281223394 835 dbSNP
rs1026226638 836 dbSNP
rs994198774 848 dbSNP
rs1443212877 849 dbSNP
rs185105870 850 dbSNP
rs1376773167 857 dbSNP
rs1241568904 860 dbSNP
rs1347677112 875 dbSNP
rs901155248 888 dbSNP
rs1381750437 895 dbSNP
rs961775437 898 dbSNP
rs1207635211 901 dbSNP
rs542859126 908 dbSNP
rs1041044345 912 dbSNP
rs942813262 913 dbSNP
rs771165221 922 dbSNP
rs1053961726 930 dbSNP
rs936834404 939 dbSNP
rs1456203796 944 dbSNP
rs574224717 949 dbSNP
rs1162830069 954 dbSNP
rs747936869 956 dbSNP
rs958525163 959 dbSNP
rs557265701 968 dbSNP
rs924231632 977 dbSNP
rs1174794046 978 dbSNP
rs1000089468 984 dbSNP
rs142327740 999 dbSNP
rs781039803 1012 dbSNP
rs949081784 1018 dbSNP
rs537185248 1019 dbSNP
rs1377876118 1022 dbSNP
rs1309797176 1024 dbSNP
rs571233269 1036 dbSNP
rs1191965466 1037 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 286676.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ccuuuguccUUUUUUGUAa 5'
                   :::|||||| 
Target 5' -------cuGGGAAACAUa 3'
1 - 12
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000273691.3 | 3UTR | CUGGGAAACAUAGUGAGACCCCGUCUCUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
107 hsa-miR-4307 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT091681 RARB retinoic acid receptor beta 2 6
MIRT097311 AGGF1 angiogenic factor with G-patch and FHA domains 1 2 2
MIRT099878 SOX4 SRY-box 4 2 2
MIRT114514 ARF6 ADP ribosylation factor 6 2 2
MIRT163479 WNT5A Wnt family member 5A 2 2
MIRT186633 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT194921 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT230189 AKAP17A A-kinase anchoring protein 17A 2 2
MIRT281397 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT328018 RLIM ring finger protein, LIM domain interacting 2 2
MIRT354896 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT361422 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT442526 MOB3B MOB kinase activator 3B 2 2
MIRT442629 NUDT12 nudix hydrolase 12 2 2
MIRT442685 SLC39A9 solute carrier family 39 member 9 2 2
MIRT444131 BRCA2 BRCA2, DNA repair associated 2 2
MIRT444174 RBM7 RNA binding motif protein 7 2 2
MIRT446045 TPR translocated promoter region, nuclear basket protein 2 2
MIRT447984 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT460527 S100A11 S100 calcium binding protein A11 2 4
MIRT466861 STX6 syntaxin 6 2 2
MIRT468806 SAP18 Sin3A associated protein 18 2 6
MIRT480269 C8orf4 chromosome 8 open reading frame 4 2 2
MIRT493119 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT499168 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 8
MIRT500507 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT503021 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT505314 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT506123 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 8
MIRT509346 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 4
MIRT509446 POU2F2 POU class 2 homeobox 2 2 6
MIRT509598 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT516008 GPN2 GPN-loop GTPase 2 2 2
MIRT516120 SRPX2 sushi repeat containing protein, X-linked 2 2 4
MIRT522126 NELL2 neural EGFL like 2 2 2
MIRT523018 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 4
MIRT524015 DONSON downstream neighbor of SON 2 2
MIRT526307 JAKMIP2 janus kinase and microtubule interacting protein 2 2 2
MIRT526789 SGCD sarcoglycan delta 2 2
MIRT529141 CLCC1 chloride channel CLIC like 1 2 2
MIRT531336 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT531573 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT531831 MTPAP mitochondrial poly(A) polymerase 2 2
MIRT534994 PRR11 proline rich 11 2 6
MIRT535419 PDZD8 PDZ domain containing 8 2 2
MIRT535534 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT536649 INIP INTS3 and NABP interacting protein 2 2
MIRT543498 MDM2 MDM2 proto-oncogene 2 4
MIRT545392 PM20D2 peptidase M20 domain containing 2 2 2
MIRT545881 ZNF200 zinc finger protein 200 2 4
MIRT547931 HNRNPR heterogeneous nuclear ribonucleoprotein R 2 2
MIRT548109 GDAP2 ganglioside induced differentiation associated protein 2 2 2
MIRT549370 ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2 2
MIRT549934 RPL7L1 ribosomal protein L7 like 1 2 4
MIRT550455 MYADM myeloid associated differentiation marker 2 4
MIRT550640 AR androgen receptor 2 2
MIRT550815 FAM229B family with sequence similarity 229 member B 2 2
MIRT551258 OPCML opioid binding protein/cell adhesion molecule like 2 2
MIRT551768 MED21 mediator complex subunit 21 2 2
MIRT552214 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT555472 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556008 MZT1 mitotic spindle organizing protein 1 2 2
MIRT557878 FEM1B fem-1 homolog B 2 4
MIRT558486 DBN1 drebrin 1 2 2
MIRT560859 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561521 AZF1 azoospermia factor 1 2 2
MIRT562090 KIAA0895 KIAA0895 2 2
MIRT563065 ZNF28 zinc finger protein 28 2 2
MIRT563487 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT564286 CTCF CCCTC-binding factor 2 2
MIRT565627 SLC16A1 solute carrier family 16 member 1 2 2
MIRT566508 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566978 LBR lamin B receptor 2 2
MIRT567180 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568432 GDNF glial cell derived neurotrophic factor 2 2
MIRT570092 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT570565 PABPC1 poly(A) binding protein cytoplasmic 1 2 2
MIRT571385 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572053 GPATCH8 G-patch domain containing 8 2 2
MIRT572333 CACNA1A calcium voltage-gated channel subunit alpha1 A 2 2
MIRT574528 PEG10 paternally expressed 10 2 2
MIRT575818 Igfbp4 insulin-like growth factor binding protein 4 2 2
MIRT608587 PPP2R1B protein phosphatase 2 scaffold subunit Abeta 2 4
MIRT610442 TSPAN15 tetraspanin 15 2 2
MIRT614994 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT615014 ERGIC2 ERGIC and golgi 2 2 2
MIRT615078 CISD3 CDGSH iron sulfur domain 3 2 2
MIRT616180 SYT7 synaptotagmin 7 2 2
MIRT617191 CDH13 cadherin 13 2 2
MIRT617287 GTF2H3 general transcription factor IIH subunit 3 2 2
MIRT618714 ESD esterase D 2 2
MIRT621825 TIMM8B translocase of inner mitochondrial membrane 8 homolog B 2 2
MIRT624139 DLX3 distal-less homeobox 3 2 2
MIRT625991 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT626344 BLOC1S4 biogenesis of lysosomal organelles complex 1 subunit 4 2 2
MIRT634899 ZNF701 zinc finger protein 701 2 2
MIRT637848 SLC2A9 solute carrier family 2 member 9 2 2
MIRT639514 FYB FYN binding protein 1 2 2
MIRT642468 RSL1D1 ribosomal L1 domain containing 1 2 2
MIRT653670 SLC26A7 solute carrier family 26 member 7 2 2
MIRT655192 PHAX phosphorylated adaptor for RNA export 2 2
MIRT657011 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT661008 ABCB11 ATP binding cassette subfamily B member 11 2 2
MIRT665816 TMEM161B transmembrane protein 161B 2 2
MIRT683852 ZNF208 zinc finger protein 208 2 2
MIRT700436 PURB purine rich element binding protein B 2 2
MIRT700517 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4307 Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4307 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4307 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4307 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine sensitive cell line (Bats-72)

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