pre-miRNA Information | |
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pre-miRNA | hsa-mir-6752 |
Genomic Coordinates | chr11: 67490245 - 67490315 |
Description | Homo sapiens miR-6752 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||
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Mature miRNA | hsa-miR-6752-3p | |||||||||||||||
Sequence | 51| UCCCUGCCCCCAUACUCCCAG |71 | |||||||||||||||
Evidence | Experimental | |||||||||||||||
Experiments | Meta-analysis | |||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | SCN1B | ||||||||||||||||||||
Synonyms | ATFB13, BRGDA5, EIEE52, GEFSP1 | ||||||||||||||||||||
Description | sodium voltage-gated channel beta subunit 1 | ||||||||||||||||||||
Transcript | NM_199037 | ||||||||||||||||||||
Other Transcripts | NM_001037 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on SCN1B | |||||||||||||||||||||
3'UTR of SCN1B (miRNA target sites are highlighted) |
>SCN1B|NM_199037|3'UTR 1 GCCATTCTTCCATCATGGGGTTCATGAGGATTGAGCAGCTGCAGGCACACGCCTGGCTTCCAGCAGAGCCTTGCAGGTGG 81 TGGCGAGGGTGGCGGTTCTTACTGTTCGAGTAGCTCAGCCCTGCTGCCCTCTGTGGTGATGAGGCAAGAGAGCGTGCCAC 161 CTAGAGCAGAGTTCCGCACACCCCTCTGCACTCCTGCCCCGGGGGAGCCGCGCTGGCCTGCAGTCTCACTCAACACCTCT 241 GGGGCGGGCCTAGGGGTCCTTTCTAAAGCTCTCAGGTGAGGCAGTGAAGGGCCACAGGTGCGGGGCCCACCCTCTGAGCA 321 GCAAGGGCCTACAGCGCTTTTGAACGTCTCATCATTTTGCCTCAGCCACCCTGGACCCCTTTTCTGAGGGAGGTCCGCCC 401 CTTCTCTGATCCATCTTCTGCTCAGCATCAATTGCAATTGTCCAGCGCCCTGTGGCCACTGGCTTAGAGTTGGGGAAACA 481 GCCCAGGCCTTGAAGCAGCTACAAGCCGTGGCAGAAAGGTCTCTCAGGGCCACGGCACACACATCCTCATGGGCAACACG 561 CACTGCCCATCTTTTCTGTGAGATGGGTGCCGGCCTCAGTGCCTTACACGGAGTCCCTTAGTGAATCCTCTCCCCACCCT 641 CTGGGGTAGGGGCTCTTCCTATCCCCATTTTACGGATGAGAAAACCAAGGCTCAGGGAGGGAAGGTTATGTGGCCAAGGT 721 CATGTGATTGGGAGCTGGACTTGAATCCAGAGGAGCTTGGGTGACTGTGTTTCTGTTCTTGGCATGATTCACTGTACTCT 801 GTGATCAGCCAGAGCCTGTGGGTTTCTTTTTATAATTAGCATTTTTACGTTTATTGTCAAATTGGTGTAGCAGAATGCAA 881 TTCAGCAGGCATGTCTGAGCCACTCTGGTGTTTGTCACGATGCTGGGGGGTGGGGGTCACCCGCAGACATGGATGATGGA 961 GCCCCGCCTGCGGAGTTGCTGTGACAAAGATGCCTGCGGTACTGGGACTTTACAAAACCTGTGTTATTGCTCTTGCAAAT 1041 CTGCAGAGGTGAGATGGGGAGAGGGTGGGAGGCTCCAGGGCACTGTTCAGCCACCCAGGTTCTTTCCATCTTGTTGTTTG 1121 GCAGTTGGCCAGGGTGTTGTGTCCTCTGTACGCCGTGACCCAATAGAGCCTCTTTTTTTTTTTTTTTAAATTTAGATTTT 1201 TATTTTTTGAGACGGAGTTTTGCTATTATTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCCCACTGCAACCTCTGCC 1281 TCCCAGGTTCAAGTGATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGTGCCACCAAGCCCAGCTAATT 1361 TTTGTATTTTTAGTAGATATGGAGTTTCCCCACATTGGCCAGGCTGGTCTCGAACTCCTGACCTTAGGTAATGATCCACC 1441 TGCCTTGGCCTCCCAAGGTGCTGGGATTACAGGTGTGAGCCACTGCGCCTGGCCTGAGCCTCTCTTTTTTAGGATTGCCC 1521 ACTGTATGACACTACATCCCACAGCCTGTGCTATTACCAGCATTTACCATCATATGCAGTTCCTTATGTTGGCCCTGCAG 1601 AGTTTGTGTTTTCTGCACTATCCACCCAGTTCTAGTGTTTTTTACCCACCATATGTAGTATTGCCTTTTAAACATTACCC 1681 ACTATATTATAGTATTTTATATTACCCACTATAGGATATTTTATATTACACAATATATTTTACTATCATAATATTGCCAA 1761 ACACAACAGTTTTTTGTTTTTTGTTAAAGAGACCAAGTCTTGCTCTGTTGCCCAGGCTGGGATACTGTGGCGTGATCATA 1841 GCCCACTGCAGCCTCGAACTCCCGAAATCCAGCGATCCTTCTGCTTGAGCCTCCCACGTAGCTGGGACTACAGGTGTGAG 1921 CCACTACGCCCGGCAATTTTTTTTTTTTTTGTAGAGACTGGATCTTGCTATGTTGCCCAGGATGGTCTTGAACTCCTGGC 2001 CTCAAATAATCTTCCCTCCTTAGCCGCCGTAAGTGCCGAGATTACAGGAGAGAGCCTCCGCGCCTGGCCTACAGTATTTT 2081 TATTATAATCCATCATACTAGCGTATTTTTAACGTTCCCCACCATGGCGGGTATTTTTATTACCCACCATGCTATGCTAT 2161 AGTATTTCAAAAATTAATCCTATTGTAGCATGTAAAAATATTCCATTCTATACCATACTATATTCATCATTACCTCTGAT 2241 ACTACAGTATTTTTAACATGACTCATTGTGCTATTGTATTTTTTCATTACCCACAATACCACAATATTACTGTATTTGTT 2321 AGCACTGCCTGCCATTCCTTATTATTATTATTTTTGCAATGGAGTCTCGCTCTGTCACCCAGGCAGGCTGGAGTGCAGCA 2401 GTACAATGTCGGCTCACTGCACCTCCCGGGCTCAAGCGATTCTTCTGCCTCAGCCTCCCAAGTAGGTGGGATTACAGGTG 2481 CACGCCACCATGCCCAACTAATTTTTGTACTTGTAGTACAGACGGGGTTTTACCATGTTGGCCAGGCTGGTCTCGAACTC 2561 CTGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGTGATTACAGGCGTAAGTTACCATGCCCAGCCTATTAT 2641 TATTATTATTATTATTATTATTATTATTTCAAGTTAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCT 2721 TGGCTCACTGCAGCCTCCATCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGAAGTAGCTGGGATTACAGG 2801 CACGCGCCACCACGCCCGGCTAATTCTTTTGTATTTTTAGTAGAGACAGGGTTTCGCTATGTAGACCAGGCTGGTCTCGC 2881 ACTCCTGGCCTCCAGTGATTCACCCACCTTGGCCTCCCAGAGTGCTGGAATGACACGTATGAGCCACCACACTGACCTTT 2961 TTATTATTTTTATCCACCATCTCGCTGCAATTTCAGTATTGCCCATCGACCTATATTGCCTCCTGGTAATGACCCCTGAG 3041 GAATGAGCCATGCCATTTCCATAGGTGGAGGCGACGGGTCATGGTGGTGAGAACTTCACTGACCTGGAAGAGGTGGAGAA 3121 GATGCTGGGAAGCTGCTGAGGGCTGCCCACCTGTGTTAGGAGAAGGCAGATGGGGACCCATGGGGACAGTAATACTATTT 3201 TGGATCCACACAACGGGAGTGGAAAATGCCTTGAGGCACAGCAGCGTCTGAGGCGGGTGAGAAATCCGGCCTGCAGAGTC 3281 GCGGCTGGCCTTCAGATCTGCGGGCTGCCTGTGAGATGCCGTGTTACCTAAATCCATTTGGGCACTGAGTTCCAGGAGTG 3361 GGGGCAAGAATTCCGATGACGGGGCTTTATCCGGTGCGCATCCAGCTCAGAGTGGTTCCTGAGACCAGCCACCATGGGCA 3441 GCCAGGATGTGCTCATCCTTGAGGCTTTCCGAGGCATCAAGGAGATGGTTGGATAAAGAATTTAGCACAGAGCTTGACTG 3521 ATGGCAGGCGCCCACAACATGAGACACATTAATAATGTGTGTGGAGGCCAGGTGTAGTGGTTCATGCCTGTCACCCCAGC 3601 ACTTTGGGAGGCAGAGGTGGGA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | hESCs (WA-09) | ||||||
Disease | 6324.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine
... - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al. - Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
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CLIP-seq Support 1 for dataset SRR359787 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | hESCs (WA-09) / 4-thiouridine, RNase T1 |
Location of target site | ENST00000262631.5 | 3UTR | CGGCAGGGGUCGCGAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22012620 / SRX103431 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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110 hsa-miR-6752-3p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT152341 | TNFSF9 | TNF superfamily member 9 | 2 | 2 | ||||||||
MIRT273594 | SP1 | Sp1 transcription factor | 2 | 2 | ||||||||
MIRT291927 | TPM4 | tropomyosin 4 | 2 | 4 | ||||||||
MIRT311186 | ANKRD33B | ankyrin repeat domain 33B | 2 | 4 | ||||||||
MIRT378521 | CDKN1A | cyclin dependent kinase inhibitor 1A | 2 | 4 | ||||||||
MIRT452467 | SORCS2 | sortilin related VPS10 domain containing receptor 2 | 2 | 2 | ||||||||
MIRT478636 | CTDNEP1 | CTD nuclear envelope phosphatase 1 | 2 | 2 | ||||||||
MIRT496343 | TMEM81 | transmembrane protein 81 | 2 | 2 | ||||||||
MIRT496646 | MFAP3 | microfibril associated protein 3 | 2 | 2 | ||||||||
MIRT496711 | DNAJC30 | DnaJ heat shock protein family (Hsp40) member C30 | 2 | 2 | ||||||||
MIRT499242 | VAV3 | vav guanine nucleotide exchange factor 3 | 2 | 4 | ||||||||
MIRT519777 | ZNF354B | zinc finger protein 354B | 2 | 6 | ||||||||
MIRT520883 | STX17 | syntaxin 17 | 2 | 2 | ||||||||
MIRT522476 | ZAK | mitogen-activated protein kinase kinase kinase 20 | 2 | 2 | ||||||||
MIRT523587 | G3BP2 | G3BP stress granule assembly factor 2 | 2 | 6 | ||||||||
MIRT525240 | KCNJ12 | potassium voltage-gated channel subfamily J member 12 | 2 | 2 | ||||||||
MIRT527025 | PABPN1L | poly(A) binding protein nuclear 1 like, cytoplasmic | 2 | 2 | ||||||||
MIRT527709 | IL17REL | interleukin 17 receptor E like | 2 | 2 | ||||||||
MIRT530778 | GPD1 | glycerol-3-phosphate dehydrogenase 1 | 2 | 2 | ||||||||
MIRT531883 | SCN1B | sodium voltage-gated channel beta subunit 1 | 2 | 2 | ||||||||
MIRT533043 | ZBTB46 | zinc finger and BTB domain containing 46 | 2 | 2 | ||||||||
MIRT535062 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | 2 | 4 | ||||||||
MIRT536512 | KCTD15 | potassium channel tetramerization domain containing 15 | 2 | 2 | ||||||||
MIRT543793 | RALGAPB | Ral GTPase activating protein non-catalytic beta subunit | 2 | 2 | ||||||||
MIRT563977 | HCFC1 | host cell factor C1 | 2 | 2 | ||||||||
MIRT569472 | MAN2A2 | mannosidase alpha class 2A member 2 | 2 | 2 | ||||||||
MIRT570600 | NFIX | nuclear factor I X | 2 | 2 | ||||||||
MIRT571402 | MED4 | mediator complex subunit 4 | 2 | 2 | ||||||||
MIRT608418 | PPIC | peptidylprolyl isomerase C | 2 | 6 | ||||||||
MIRT608928 | REXO2 | RNA exonuclease 2 | 2 | 4 | ||||||||
MIRT609357 | ZNF664 | zinc finger protein 664 | 2 | 2 | ||||||||
MIRT611189 | WBSCR17 | polypeptide N-acetylgalactosaminyltransferase 17 | 2 | 4 | ||||||||
MIRT615266 | DPF2 | double PHD fingers 2 | 2 | 2 | ||||||||
MIRT615408 | VDAC2 | voltage dependent anion channel 2 | 2 | 2 | ||||||||
MIRT616323 | AGO3 | argonaute 3, RISC catalytic component | 2 | 2 | ||||||||
MIRT616566 | ZNF512B | zinc finger protein 512B | 2 | 2 | ||||||||
MIRT616745 | TAZ | tafazzin | 2 | 2 | ||||||||
MIRT617316 | MBOAT1 | membrane bound O-acyltransferase domain containing 1 | 2 | 2 | ||||||||
MIRT620030 | NFAM1 | NFAT activating protein with ITAM motif 1 | 2 | 2 | ||||||||
MIRT621166 | RTTN | rotatin | 2 | 2 | ||||||||
MIRT623501 | KCNQ3 | potassium voltage-gated channel subfamily Q member 3 | 2 | 2 | ||||||||
MIRT623524 | KCNK10 | potassium two pore domain channel subfamily K member 10 | 2 | 2 | ||||||||
MIRT629683 | TNFAIP8L1 | TNF alpha induced protein 8 like 1 | 2 | 2 | ||||||||
MIRT630795 | TGIF2 | TGFB induced factor homeobox 2 | 2 | 2 | ||||||||
MIRT634638 | HIP1 | huntingtin interacting protein 1 | 2 | 4 | ||||||||
MIRT636788 | RAB40B | RAB40B, member RAS oncogene family | 2 | 2 | ||||||||
MIRT640332 | DAAM2 | dishevelled associated activator of morphogenesis 2 | 2 | 2 | ||||||||
MIRT640557 | SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 | 2 | 2 | ||||||||
MIRT643319 | TMEM151B | transmembrane protein 151B | 2 | 2 | ||||||||
MIRT643991 | DUSP28 | dual specificity phosphatase 28 | 2 | 2 | ||||||||
MIRT644618 | CD300E | CD300e molecule | 2 | 2 | ||||||||
MIRT646445 | XRCC2 | X-ray repair cross complementing 2 | 2 | 2 | ||||||||
MIRT648020 | SLCO4C1 | solute carrier organic anion transporter family member 4C1 | 2 | 2 | ||||||||
MIRT648077 | ZMIZ2 | zinc finger MIZ-type containing 2 | 2 | 2 | ||||||||
MIRT649618 | ITPKC | inositol-trisphosphate 3-kinase C | 2 | 2 | ||||||||
MIRT650414 | ZNF442 | zinc finger protein 442 | 2 | 2 | ||||||||
MIRT650850 | SEMA4G | semaphorin 4G | 2 | 2 | ||||||||
MIRT654694 | PSMB5 | proteasome subunit beta 5 | 2 | 2 | ||||||||
MIRT655512 | PAIP2B | poly(A) binding protein interacting protein 2B | 2 | 2 | ||||||||
MIRT657620 | GRAP2 | GRB2-related adaptor protein 2 | 2 | 2 | ||||||||
MIRT658009 | GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 2 | 2 | ||||||||
MIRT658329 | FAM83F | family with sequence similarity 83 member F | 2 | 2 | ||||||||
MIRT658832 | SRCAP | Snf2 related CREBBP activator protein | 2 | 2 | ||||||||
MIRT658920 | DPY19L4 | dpy-19 like 4 | 2 | 2 | ||||||||
MIRT661058 | RPL18A | ribosomal protein L18a | 2 | 2 | ||||||||
MIRT662342 | MYLK3 | myosin light chain kinase 3 | 2 | 2 | ||||||||
MIRT663451 | FBXO2 | F-box protein 2 | 2 | 2 | ||||||||
MIRT676752 | SGTB | small glutamine rich tetratricopeptide repeat containing beta | 2 | 4 | ||||||||
MIRT684705 | LRRD1 | leucine rich repeats and death domain containing 1 | 2 | 2 | ||||||||
MIRT687247 | PDHB | pyruvate dehydrogenase E1 beta subunit | 2 | 2 | ||||||||
MIRT693881 | NT5C2 | 5'-nucleotidase, cytosolic II | 2 | 2 | ||||||||
MIRT693922 | HNRNPA1L2 | heterogeneous nuclear ribonucleoprotein A1-like 2 | 2 | 2 | ||||||||
MIRT695921 | ZNF174 | zinc finger protein 174 | 2 | 2 | ||||||||
MIRT702867 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 2 | 2 | ||||||||
MIRT708863 | TMSB4X | thymosin beta 4, X-linked | 2 | 2 | ||||||||
MIRT708936 | CRY2 | cryptochrome circadian clock 2 | 2 | 2 | ||||||||
MIRT709476 | FAXC | failed axon connections homolog | 2 | 2 | ||||||||
MIRT709752 | UBD | ubiquitin D | 2 | 2 | ||||||||
MIRT710128 | VANGL2 | VANGL planar cell polarity protein 2 | 2 | 2 | ||||||||
MIRT710274 | FAM107A | family with sequence similarity 107 member A | 2 | 2 | ||||||||
MIRT711146 | TMEM174 | transmembrane protein 174 | 2 | 2 | ||||||||
MIRT712582 | ATP2B4 | ATPase plasma membrane Ca2+ transporting 4 | 2 | 2 | ||||||||
MIRT712648 | TXNL4A | thioredoxin like 4A | 2 | 2 | ||||||||
MIRT713325 | TMEM44 | transmembrane protein 44 | 2 | 2 | ||||||||
MIRT713413 | PEX16 | peroxisomal biogenesis factor 16 | 2 | 2 | ||||||||
MIRT713891 | RNF19B | ring finger protein 19B | 2 | 2 | ||||||||
MIRT714549 | COL14A1 | collagen type XIV alpha 1 chain | 2 | 2 | ||||||||
MIRT714809 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | 2 | 2 | ||||||||
MIRT714840 | SCAMP2 | secretory carrier membrane protein 2 | 2 | 2 | ||||||||
MIRT715779 | DDX42 | DEAD-box helicase 42 | 2 | 2 | ||||||||
MIRT715795 | TBL3 | transducin beta like 3 | 2 | 2 | ||||||||
MIRT716088 | RNF150 | ring finger protein 150 | 2 | 2 | ||||||||
MIRT716712 | IMP4 | IMP4, U3 small nucleolar ribonucleoprotein | 2 | 2 | ||||||||
MIRT716737 | APOL6 | apolipoprotein L6 | 2 | 2 | ||||||||
MIRT717069 | MTMR6 | myotubularin related protein 6 | 2 | 2 | ||||||||
MIRT718185 | HLCS | holocarboxylase synthetase | 2 | 2 | ||||||||
MIRT719386 | SECTM1 | secreted and transmembrane 1 | 2 | 2 | ||||||||
MIRT720679 | SLC39A13 | solute carrier family 39 member 13 | 2 | 2 | ||||||||
MIRT721315 | FAM58A | cyclin Q | 2 | 2 | ||||||||
MIRT721396 | LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | 2 | 2 | ||||||||
MIRT721896 | ITPR2 | inositol 1,4,5-trisphosphate receptor type 2 | 2 | 2 | ||||||||
MIRT722442 | ZBTB7B | zinc finger and BTB domain containing 7B | 2 | 2 | ||||||||
MIRT723009 | FADS1 | fatty acid desaturase 1 | 2 | 2 | ||||||||
MIRT723675 | CTC1 | CST telomere replication complex component 1 | 2 | 2 | ||||||||
MIRT723774 | ROBO4 | roundabout guidance receptor 4 | 2 | 2 | ||||||||
MIRT723814 | OR1L8 | olfactory receptor family 1 subfamily L member 8 | 2 | 2 | ||||||||
MIRT723959 | TMEM184A | transmembrane protein 184A | 2 | 2 | ||||||||
MIRT724449 | OPA3 | OPA3, outer mitochondrial membrane lipid metabolism regulator | 2 | 2 | ||||||||
MIRT724798 | C1D | C1D nuclear receptor corepressor | 2 | 2 | ||||||||
MIRT725626 | CAMKV | CaM kinase like vesicle associated | 2 | 2 |