pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ACTR2   
Synonyms ARP2
Description ARP2 actin related protein 2 homolog
Transcript NM_001005386   
Other Transcripts NM_005722   
Expression
Putative miRNA Targets on ACTR2
3'UTR of ACTR2
(miRNA target sites are highlighted)
>ACTR2|NM_001005386|3'UTR
   1 ACTCCAAAGCTTGTTCCCGTCATACCCGTAATGCTTTCTTTTTTCCTTTATTGCCAATCTTTGAACTCATTCAACTCCAG
  81 GACATGGAAGAGGCCTCTCTCTGCCCTTTGACTGGAAAGGTCAAGTTTTATTCTGGTGTCTTGGGGAAGCTTTGTTAAAT
 161 TTTTGTTAATGTGGGTAAATCTGAGTTTAATTCAACTGCTTCCCTACATAGACTAGAGGGCTAAGGATTCTGTCTGCTGC
 241 TTTGTTTCTTCTAAGTAGGCATTTAGATCATTCCTATAGGCTTCCTATTTTCACTTTACTGCTCTAATGCTGCTAGTCGT
 321 AGTCTTTAGCACACTAGGTGGTATGCCTTTATTAGCATAAAACAAAAAAAACTTTAACAGGAGCTTTTACATATTACTGG
 401 GATGGGGGGTGGTTCGGGATGGGTGGGCAGCTGCTGAACCCTTTAGGGCATTTCCTCTGTAATGTGGCGCTTTCAACTGT
 481 ACTGCTGCAGCTTTAAGTACCTTAAAGCTTCTCCTGTGAACTTCTTAGGGAAATGTTAGGTTCAGAACTAAAGTGTTTTG
 561 GGTGGGTTTTGTTGCGGGGGGGAGGGTAACAATGGGTGGTCTTCTGATTTTTATTTTTGAGGTTTTGTCAACTGGAGTAC
 641 GTAGAGGAACTTTATTTACAGTACTTTGATTTGGCAGGTTTTCTTCTACTTGTGCTCTGCCTGGAGCTGTTTCCATATGA
 721 TATAAAAAGCAAGTGTAGTATTCCATTACTATGTGGCTTAGGGATTTATTTGTTTTTTAAAATCAACCATGTTAGCTGGG
 801 ATTAGACTCCCTACAGTCCTTCAATGGAAAAGTAACATTTAAAAATCCTTTGGGTAATTCGAATTACAGATTTAAAAGAG
 881 CTTAAGATCTGGTGTTTTGTTAATGCTTCTGTTTATTCCAGAAGCATTAAGGTAACCCATTGCCAAGTATCATTCTTGCA
 961 AATTATTCTTTTATATAACTGACCAGTGCTTAATAAAACAAGCAGGTACTTACAAATAATTACTGGCAGTAGGTTATAAT
1041 TGGTGGTTTAAAAATAACATTGGAATACAGGACTTGTTGCCAATTGGGTAATTTTCATTAGTTGTTTTGTTTGTTTTGAT
1121 TTGAAACCTGGAAATACAGTAAAATTTGACTGTTTAAAATGTTGGCCAAAAAAATCAAGATTTAATTTTTTTATTTGTAC
1201 TGAAAAACTAATCATAACTGTTAATTCTCAGCCATCTTTGAAGCTTGAAAGAAGAGTCTTTGGTATTTTGTAAACGTTAG
1281 CAGACTTTCCTGCCAGTGTCAGAAAATCCTATTTATGAATCCTGTCGGTATTCCTTGGTATCTGAAAAAAATACCAAATA
1361 GTACCATACATGAGTTATTTCTAAGTTTGAAAAATAAAAAGAAATTGCATCACACTAATTACAAAATACAAGTTCTGGAA
1441 AAAATATTTTTCTTCATTTTAAAACTTTTTTTTAACTAATAATAGCTTTGAAAGAAGAGGCTTAATTTGGGGGTGGTAAC
1521 TAAAATCAAAAGAAATGATTGACTTGAGGGTCTCTGTTTGGTAAGAATACATCATTAGCTTAAATAAGCAGCAGAAGGTT
1601 AGTTTTAATTATGTAGCTTCTGTTAATATTAAGTGTTTTTTGTCTGTTTTACCTCAATTTGAACAGATAAGTTTGCCTGC
1681 ATGCTGGACATGCCTCAGAACCCTGAATAGCCCGTACTAGATCTTGGGAACATGGATCTTAGAGTCACTTTGGAATAAGT
1761 TCTTATATAAATACCCCCAGCCTTTTGAGAACGGGGCTTGTTAAAGGACGCGTATGTAGGGCCCGTACCTACTGGCAGTT
1841 GGGTTCAGGGAAATGGGATTGACTTGGCCTTCAGGCTCCTTTGGTCATAATTTTAAAATATGGGAGTAGAAAACAACAAA
1921 GAATGGAATGGACTCTTAAAACAATGAAAGAGCATTTATCGTTTGTCCCTTGAATGTAGAATTTGTTTTTGATTTCATAA
2001 TTCTGCTGGTAAATGTGACAGTTAAAATGGTGCATTATGTATATATATTATAATTTAGAAATACCATTTTATAATTTTAC
2081 TATTCCAGGGTGACATAATGCATTTAAATTTGGGATTTGGGTGGAGTATTATGTTTAACTGGAGTTGTCAAGTATGAGTC
2161 CCTCAGGAAAAAAAAAAAATTCTGTTTTAAAAAGCAATCTGATTCTTAGCTCTTGAAACTATTGCTACTTAAATTTCCAA
2241 TAATTAAAAATTTAAAATTTTTAAATTAGAATTGCCAATACTTCTACATTTGAGAAGGGTTTTTTTAGAAATACATTTAG
2321 TAAAGTCCCCAAGACATTAGTCTTACATTTAAACTTTTTTCTTTAAAACATGGTTTTGGTGGTTAACTTTTACACAGTTC
2401 TGAGTACTGTTAATATCTGGAAAGTATCTTGAGATATCAGTGGAAAGCTAAACAGTCTAAATTAACATGAAATACTTCAT
2481 TTTGATTGAGAAAATAAAATCAGATTTTTTCAAAGTCAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cacACGAGAGA--CCAGUUGGUAg 5'
             ||:|:|:|    |||||||| 
Target 5' attTGTTTTTTAAAATCAACCATg 3'
768 - 791 157.00 -12.10
2
miRNA  3' cacACGAGAGACCAGUUGGUAg 5'
             ||:|  :|  |||:|||| 
Target 5' aacTGTTAATT-CTCAGCCATc 3'
1216 - 1236 134.00 -12.80
3
miRNA  3' caCA-CGAGAGACCAGUUGGUAg 5'
            || || ||:   |||||::| 
Target 5' atGTGGCGCTT---TCAACTGTa 3'
462 - 481 121.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30126740 18 COSMIC
COSN30525843 28 COSMIC
COSN9383683 35 COSMIC
COSN30150392 39 COSMIC
COSN30148117 41 COSMIC
COSN31598250 41 COSMIC
COSN6190449 122 COSMIC
COSN31512627 132 COSMIC
COSN30500564 133 COSMIC
COSN31608844 134 COSMIC
COSN18727311 151 COSMIC
COSN16680035 157 COSMIC
COSN31604284 159 COSMIC
COSN31554047 219 COSMIC
COSN28671660 320 COSMIC
COSN31596819 349 COSMIC
COSN7080165 779 COSMIC
COSN9383684 1186 COSMIC
COSN15129132 1187 COSMIC
COSN15129131 1228 COSMIC
COSN27798495 1277 COSMIC
COSN7080166 1344 COSMIC
COSN14453233 1397 COSMIC
COSN21647591 1397 COSMIC
COSN20096781 1473 COSMIC
COSN26888656 1671 COSMIC
COSN15204820 1714 COSMIC
COSN29692920 2307 COSMIC
rs17038564 191 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs770390466 8 dbSNP
rs776047161 11 dbSNP
rs199819019 14 dbSNP
rs268875 20 dbSNP
rs1333763454 22 dbSNP
rs752112550 24 dbSNP
rs1274575076 27 dbSNP
rs1205040048 28 dbSNP
rs775919693 28 dbSNP
rs368001778 29 dbSNP
rs1270374589 32 dbSNP
rs987854705 35 dbSNP
rs188171224 37 dbSNP
rs1481447375 39 dbSNP
rs1291670816 52 dbSNP
rs1235440012 55 dbSNP
rs1341125491 56 dbSNP
rs1295006048 58 dbSNP
rs1380426675 60 dbSNP
rs139637582 70 dbSNP
rs943417335 73 dbSNP
rs562834420 75 dbSNP
rs1213909526 77 dbSNP
rs1460734411 79 dbSNP
rs1392108232 81 dbSNP
rs1270684542 91 dbSNP
rs531370847 95 dbSNP
rs1309012017 96 dbSNP
rs548385656 97 dbSNP
rs113084011 104 dbSNP
rs561798444 107 dbSNP
rs1472952044 112 dbSNP
rs929150431 113 dbSNP
rs527787336 116 dbSNP
rs1427212713 122 dbSNP
rs895709974 125 dbSNP
rs1190231666 141 dbSNP
rs1238110487 144 dbSNP
rs1014183016 149 dbSNP
rs11424 151 dbSNP
rs570506885 157 dbSNP
rs905529829 160 dbSNP
rs1000349797 169 dbSNP
rs1032758839 177 dbSNP
rs17038564 191 dbSNP
rs1009714391 196 dbSNP
rs1021097952 200 dbSNP
rs1440156266 203 dbSNP
rs955102221 204 dbSNP
rs1432477697 207 dbSNP
rs8771 208 dbSNP
rs1395358723 215 dbSNP
rs1165599395 216 dbSNP
rs910506290 222 dbSNP
rs964782156 227 dbSNP
rs1454259373 231 dbSNP
rs1429989157 235 dbSNP
rs1268309180 236 dbSNP
rs1363827084 261 dbSNP
rs1201505234 262 dbSNP
rs1228777830 268 dbSNP
rs1279334583 275 dbSNP
rs190577 277 dbSNP
rs1275503953 285 dbSNP
rs370593620 288 dbSNP
rs920699521 291 dbSNP
rs1276341151 298 dbSNP
rs1436943566 305 dbSNP
rs929392696 307 dbSNP
rs1326444522 308 dbSNP
rs1392833922 314 dbSNP
rs1047564133 319 dbSNP
rs12560 320 dbSNP
rs1446461413 321 dbSNP
rs1191691726 325 dbSNP
rs1452503144 330 dbSNP
rs949968680 333 dbSNP
rs1363641766 364 dbSNP
rs1179893785 367 dbSNP
rs1484181293 378 dbSNP
rs1450485816 381 dbSNP
rs1210279751 383 dbSNP
rs4513276 384 dbSNP
rs1393645702 389 dbSNP
rs866520607 392 dbSNP
rs1349670589 395 dbSNP
rs572719866 402 dbSNP
rs999848289 405 dbSNP
rs1399566837 406 dbSNP
rs891523866 407 dbSNP
rs1360456455 413 dbSNP
rs1336702704 416 dbSNP
rs1415592358 417 dbSNP
rs533871868 420 dbSNP
rs1157221274 426 dbSNP
rs541485422 434 dbSNP
rs1346958087 436 dbSNP
rs1435703690 445 dbSNP
rs1302471277 447 dbSNP
rs561718165 449 dbSNP
rs1021047294 451 dbSNP
rs1239349885 453 dbSNP
rs1275611492 455 dbSNP
rs1446401877 462 dbSNP
rs954906248 469 dbSNP
rs576748675 470 dbSNP
rs1017892199 477 dbSNP
rs777868872 488 dbSNP
rs539690732 492 dbSNP
rs1284319507 497 dbSNP
rs180714852 501 dbSNP
rs1318879808 504 dbSNP
rs950742313 506 dbSNP
rs1389918223 509 dbSNP
rs749401354 511 dbSNP
rs1251570100 518 dbSNP
rs562611387 521 dbSNP
rs917067165 523 dbSNP
rs1200582684 534 dbSNP
rs1416017572 538 dbSNP
rs1182553482 541 dbSNP
rs949947806 543 dbSNP
rs1240297481 549 dbSNP
rs1190194900 551 dbSNP
rs980414308 561 dbSNP
rs576287967 562 dbSNP
rs1272370715 563 dbSNP
rs541582165 576 dbSNP
rs927257754 576 dbSNP
rs935938786 576 dbSNP
rs1054021926 577 dbSNP
rs1469302964 578 dbSNP
rs187273512 579 dbSNP
rs527527173 582 dbSNP
rs139537253 583 dbSNP
rs1050905175 586 dbSNP
rs1388471550 589 dbSNP
rs771091507 593 dbSNP
rs1450049243 596 dbSNP
rs1325092443 597 dbSNP
rs1252103288 600 dbSNP
rs1191537097 607 dbSNP
rs890612819 625 dbSNP
rs1392047519 631 dbSNP
rs1009088956 641 dbSNP
rs1442756338 641 dbSNP
rs564258491 642 dbSNP
rs1335468967 651 dbSNP
rs1305239622 654 dbSNP
rs1276221948 688 dbSNP
rs1237139023 689 dbSNP
rs1343542852 693 dbSNP
rs1303073128 695 dbSNP
rs1281397978 696 dbSNP
rs533148722 703 dbSNP
rs1233249003 704 dbSNP
rs1294337307 719 dbSNP
rs1271773159 723 dbSNP
rs1441815727 734 dbSNP
rs900723738 735 dbSNP
rs1309969134 741 dbSNP
rs769192695 744 dbSNP
rs192176615 746 dbSNP
rs570215938 752 dbSNP
rs983526434 753 dbSNP
rs746715620 754 dbSNP
rs1024420884 768 dbSNP
rs868552664 790 dbSNP
rs1253381618 791 dbSNP
rs1483635624 800 dbSNP
rs1472604913 803 dbSNP
rs1280251231 808 dbSNP
rs927132960 815 dbSNP
rs1164144301 817 dbSNP
rs1302458247 823 dbSNP
rs1415495583 825 dbSNP
rs777074458 826 dbSNP
rs935887068 830 dbSNP
rs35502573 832 dbSNP
rs386646816 845 dbSNP
rs367922721 853 dbSNP
rs536138518 854 dbSNP
rs1467563020 858 dbSNP
rs1395478939 861 dbSNP
rs10116 862 dbSNP
rs1158149680 863 dbSNP
rs1310047655 865 dbSNP
rs771891280 873 dbSNP
rs945751287 873 dbSNP
rs1414189304 875 dbSNP
rs1291502778 880 dbSNP
rs1337653323 886 dbSNP
rs1253537580 890 dbSNP
rs1199213988 892 dbSNP
rs1051276431 895 dbSNP
rs1246133715 896 dbSNP
rs1256904965 914 dbSNP
rs183561748 926 dbSNP
rs942455645 947 dbSNP
rs374689475 952 dbSNP
rs1193737612 957 dbSNP
rs149665205 967 dbSNP
rs34642294 983 dbSNP
rs900672802 985 dbSNP
rs1354874455 986 dbSNP
rs995084130 990 dbSNP
rs1397677780 1000 dbSNP
rs1379838763 1014 dbSNP
rs1288015319 1024 dbSNP
rs773520905 1033 dbSNP
rs535266988 1039 dbSNP
rs1004908433 1042 dbSNP
rs376566788 1044 dbSNP
rs1024746065 1059 dbSNP
rs971478838 1060 dbSNP
rs1257486263 1061 dbSNP
rs1188557033 1067 dbSNP
rs1463812041 1084 dbSNP
rs1372322640 1085 dbSNP
rs10496124 1086 dbSNP
rs1170733839 1088 dbSNP
rs1355953964 1106 dbSNP
rs1034149560 1109 dbSNP
rs1371331894 1111 dbSNP
rs1294767543 1113 dbSNP
rs957242503 1114 dbSNP
rs1367068056 1119 dbSNP
rs990020874 1123 dbSNP
rs1439644272 1124 dbSNP
rs1434322770 1128 dbSNP
rs913182814 1138 dbSNP
rs1164417652 1151 dbSNP
rs1457962574 1155 dbSNP
rs1372054980 1173 dbSNP
rs1168479125 1177 dbSNP
rs1250248845 1178 dbSNP
rs1189641804 1183 dbSNP
rs199877974 1187 dbSNP
rs967283767 1193 dbSNP
rs576892638 1209 dbSNP
rs1211927762 1219 dbSNP
rs1265545573 1219 dbSNP
rs986451644 1221 dbSNP
rs1381384852 1223 dbSNP
rs72822405 1228 dbSNP
rs912221621 1235 dbSNP
rs539016319 1237 dbSNP
rs1297985651 1238 dbSNP
rs1233295743 1240 dbSNP
rs1329199697 1249 dbSNP
rs942424648 1252 dbSNP
rs1039897405 1270 dbSNP
rs922086018 1271 dbSNP
rs1275793381 1276 dbSNP
rs1342507499 1277 dbSNP
rs368325470 1289 dbSNP
rs1169550097 1304 dbSNP
rs11553103 1306 dbSNP
rs146651029 1312 dbSNP
rs190419042 1317 dbSNP
rs1049323557 1320 dbSNP
rs1452450681 1323 dbSNP
rs1251121639 1326 dbSNP
rs182676759 1327 dbSNP
rs1483957033 1328 dbSNP
rs1275258142 1356 dbSNP
rs1426528007 1367 dbSNP
rs1190332909 1368 dbSNP
rs570683990 1371 dbSNP
rs1454027604 1383 dbSNP
rs186983770 1387 dbSNP
rs11698 1395 dbSNP
rs1466557635 1397 dbSNP
rs1288812716 1409 dbSNP
rs1001625968 1415 dbSNP
rs1370712387 1418 dbSNP
rs1158031762 1426 dbSNP
rs1309161084 1432 dbSNP
rs1414449653 1440 dbSNP
rs1400479411 1447 dbSNP
rs1174711501 1451 dbSNP
rs1437895819 1457 dbSNP
rs1478445168 1466 dbSNP
rs3832136 1466 dbSNP
rs869115891 1466 dbSNP
rs957191242 1468 dbSNP
rs1298852051 1469 dbSNP
rs1011390402 1471 dbSNP
rs564381033 1472 dbSNP
rs1020085721 1474 dbSNP
rs967284283 1474 dbSNP
rs1233134837 1479 dbSNP
rs268877 1485 dbSNP
rs1265849594 1501 dbSNP
rs1229915505 1502 dbSNP
rs1350545957 1505 dbSNP
rs912226127 1513 dbSNP
rs1447895905 1514 dbSNP
rs1339250693 1523 dbSNP
rs11553102 1533 dbSNP
rs533057055 1555 dbSNP
rs1470504787 1564 dbSNP
rs12618260 1579 dbSNP
rs1388439199 1591 dbSNP
rs192348496 1596 dbSNP
rs1459054829 1597 dbSNP
rs975176120 1599 dbSNP
rs1162758989 1601 dbSNP
rs1471738411 1625 dbSNP
rs563699656 1630 dbSNP
rs1239141677 1636 dbSNP
rs529300822 1639 dbSNP
rs1484878219 1643 dbSNP
rs140238683 1645 dbSNP
rs1248439273 1647 dbSNP
rs1246017962 1651 dbSNP
rs566393182 1657 dbSNP
rs755913213 1658 dbSNP
rs528669139 1665 dbSNP
rs1427459535 1666 dbSNP
rs552005226 1667 dbSNP
rs570410741 1668 dbSNP
rs535115073 1671 dbSNP
rs777566327 1681 dbSNP
rs1454028103 1686 dbSNP
rs940914467 1689 dbSNP
rs539508101 1691 dbSNP
rs1046444819 1692 dbSNP
rs907195464 1693 dbSNP
rs268878 1704 dbSNP
rs1403675154 1705 dbSNP
rs756917592 1707 dbSNP
rs1291440976 1709 dbSNP
rs1416130043 1712 dbSNP
rs776012588 1714 dbSNP
rs144470997 1715 dbSNP
rs1011622627 1717 dbSNP
rs1190301560 1719 dbSNP
rs1326407366 1724 dbSNP
rs1245764523 1725 dbSNP
rs1020034956 1727 dbSNP
rs1230189520 1732 dbSNP
rs1268614378 1733 dbSNP
rs903052848 1734 dbSNP
rs182663794 1737 dbSNP
rs1342100697 1739 dbSNP
rs1295779550 1741 dbSNP
rs1219179525 1743 dbSNP
rs1231084961 1745 dbSNP
rs7246 1767 dbSNP
rs1293150233 1769 dbSNP
rs1434649675 1772 dbSNP
rs1351659072 1774 dbSNP
rs555216731 1775 dbSNP
rs963729110 1782 dbSNP
rs975051281 1790 dbSNP
rs572014687 1793 dbSNP
rs1428880427 1794 dbSNP
rs1424262564 1801 dbSNP
rs188856002 1810 dbSNP
rs1248535857 1811 dbSNP
rs1473589589 1812 dbSNP
rs982532630 1813 dbSNP
rs13812 1815 dbSNP
rs940891736 1825 dbSNP
rs981705678 1826 dbSNP
rs1301068923 1829 dbSNP
rs1217649138 1830 dbSNP
rs1306647570 1838 dbSNP
rs1283942832 1841 dbSNP
rs193230996 1847 dbSNP
rs1368853931 1848 dbSNP
rs1309749814 1860 dbSNP
rs543877235 1862 dbSNP
rs924908241 1867 dbSNP
rs1350814397 1891 dbSNP
rs937628876 1901 dbSNP
rs563667650 1902 dbSNP
rs1429556922 1907 dbSNP
rs1181098775 1914 dbSNP
rs1055686634 1918 dbSNP
rs893138446 1921 dbSNP
rs947470263 1932 dbSNP
rs1481264405 1941 dbSNP
rs1255722335 1942 dbSNP
rs143363561 1947 dbSNP
rs1314097252 1953 dbSNP
rs543064379 1958 dbSNP
rs115509130 1959 dbSNP
rs1228066006 1962 dbSNP
rs1348674849 1970 dbSNP
rs1290326538 1984 dbSNP
rs767865375 2015 dbSNP
rs1226505688 2033 dbSNP
rs200535471 2034 dbSNP
rs1315728684 2042 dbSNP
rs770158496 2046 dbSNP
rs1406622139 2048 dbSNP
rs1157933181 2053 dbSNP
rs1455356451 2055 dbSNP
rs1413485000 2058 dbSNP
rs10190237 2059 dbSNP
rs1019462308 2066 dbSNP
rs899718211 2067 dbSNP
rs12561 2074 dbSNP
rs1244174407 2083 dbSNP
rs1026611811 2107 dbSNP
rs1327369389 2114 dbSNP
rs1270026758 2116 dbSNP
rs1239863681 2122 dbSNP
rs1988446 2124 dbSNP
rs531036860 2127 dbSNP
rs1310473676 2128 dbSNP
rs1397768643 2133 dbSNP
rs796751763 2141 dbSNP
rs1183054519 2145 dbSNP
rs1383222824 2150 dbSNP
rs1256888047 2157 dbSNP
rs1432379116 2161 dbSNP
rs778274471 2165 dbSNP
rs1236051258 2168 dbSNP
rs1390402357 2168 dbSNP
rs982522732 2168 dbSNP
rs1015790282 2169 dbSNP
rs1472126241 2177 dbSNP
rs962220437 2180 dbSNP
rs928825143 2181 dbSNP
rs981995709 2181 dbSNP
rs1264115309 2184 dbSNP
rs147065324 2190 dbSNP
rs1488187041 2191 dbSNP
rs184453141 2196 dbSNP
rs1347285515 2197 dbSNP
rs1169327238 2198 dbSNP
rs1360106832 2199 dbSNP
rs1208762989 2205 dbSNP
rs1296526037 2217 dbSNP
rs535040303 2219 dbSNP
rs1367181069 2220 dbSNP
rs914564647 2240 dbSNP
rs947418453 2247 dbSNP
rs1041764109 2255 dbSNP
rs903242939 2258 dbSNP
rs1366732002 2259 dbSNP
rs1168583526 2260 dbSNP
rs1448028704 2279 dbSNP
rs1375194464 2282 dbSNP
rs944148739 2287 dbSNP
rs1041243967 2289 dbSNP
rs1368380463 2295 dbSNP
rs899668178 2300 dbSNP
rs774777808 2307 dbSNP
rs138262060 2310 dbSNP
rs11542083 2312 dbSNP
rs1270581065 2315 dbSNP
rs1232014182 2317 dbSNP
rs1329009070 2319 dbSNP
rs1302672412 2321 dbSNP
rs534603143 2322 dbSNP
rs557795479 2323 dbSNP
rs188901015 2331 dbSNP
rs143860273 2332 dbSNP
rs1307932467 2337 dbSNP
rs757334204 2341 dbSNP
rs201798478 2345 dbSNP
rs1399037509 2352 dbSNP
rs1168877751 2356 dbSNP
rs15201 2362 dbSNP
rs1465681381 2371 dbSNP
rs779000672 2375 dbSNP
rs1201953829 2379 dbSNP
rs970856956 2380 dbSNP
rs557399421 2383 dbSNP
rs1251241138 2385 dbSNP
rs574182755 2404 dbSNP
rs1439512043 2406 dbSNP
rs543001021 2407 dbSNP
rs1344661087 2424 dbSNP
rs10717 2428 dbSNP
rs752630774 2441 dbSNP
rs1206094817 2454 dbSNP
rs1342692924 2455 dbSNP
rs1264601661 2457 dbSNP
rs546113624 2459 dbSNP
rs1036263919 2462 dbSNP
rs1279739207 2466 dbSNP
rs569710328 2473 dbSNP
rs7247 2473 dbSNP
rs1440736383 2476 dbSNP
rs1338065297 2483 dbSNP
rs1329890315 2485 dbSNP
rs991687139 2487 dbSNP
rs1395809552 2488 dbSNP
rs914849139 2489 dbSNP
rs968959795 2491 dbSNP
rs1238500577 2502 dbSNP
rs1470442447 2504 dbSNP
rs1475367596 2505 dbSNP
rs977796417 2512 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 10097.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cacacgagagacCAGUUGGUag 5'
                      ||:|:|::  
Target 5' ----------auGUUAGCUGgg 3'
1 - 12
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cacacgagagacCAGUUGGUag 5'
                      ||:|:|::  
Target 5' -----------uGUUAGCUGgg 3'
1 - 11
Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000260641.5 | 3UTR | AUGUUAGCUGGGAUUAGACUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

Error report submission