pre-miRNA Information | |
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pre-miRNA | hsa-mir-758 |
Genomic Coordinates | chr14: 101026020 - 101026107 |
Synonyms | MIRN758, hsa-mir-758, MIR758 |
Description | Homo sapiens miR-758 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-758-5p | |||||||||||||||||||||||||||||||||||||||||||||
Sequence | 15| GAUGGUUGACCAGAGAGCACAC |36 | |||||||||||||||||||||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||||||||||||||||||||
Experiments | SOLiD | |||||||||||||||||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ACTR2 | ||||||||||||||||||||
Synonyms | ARP2 | ||||||||||||||||||||
Description | ARP2 actin related protein 2 homolog | ||||||||||||||||||||
Transcript | NM_001005386 | ||||||||||||||||||||
Other Transcripts | NM_005722 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ACTR2 | |||||||||||||||||||||
3'UTR of ACTR2 (miRNA target sites are highlighted) |
>ACTR2|NM_001005386|3'UTR 1 ACTCCAAAGCTTGTTCCCGTCATACCCGTAATGCTTTCTTTTTTCCTTTATTGCCAATCTTTGAACTCATTCAACTCCAG 81 GACATGGAAGAGGCCTCTCTCTGCCCTTTGACTGGAAAGGTCAAGTTTTATTCTGGTGTCTTGGGGAAGCTTTGTTAAAT 161 TTTTGTTAATGTGGGTAAATCTGAGTTTAATTCAACTGCTTCCCTACATAGACTAGAGGGCTAAGGATTCTGTCTGCTGC 241 TTTGTTTCTTCTAAGTAGGCATTTAGATCATTCCTATAGGCTTCCTATTTTCACTTTACTGCTCTAATGCTGCTAGTCGT 321 AGTCTTTAGCACACTAGGTGGTATGCCTTTATTAGCATAAAACAAAAAAAACTTTAACAGGAGCTTTTACATATTACTGG 401 GATGGGGGGTGGTTCGGGATGGGTGGGCAGCTGCTGAACCCTTTAGGGCATTTCCTCTGTAATGTGGCGCTTTCAACTGT 481 ACTGCTGCAGCTTTAAGTACCTTAAAGCTTCTCCTGTGAACTTCTTAGGGAAATGTTAGGTTCAGAACTAAAGTGTTTTG 561 GGTGGGTTTTGTTGCGGGGGGGAGGGTAACAATGGGTGGTCTTCTGATTTTTATTTTTGAGGTTTTGTCAACTGGAGTAC 641 GTAGAGGAACTTTATTTACAGTACTTTGATTTGGCAGGTTTTCTTCTACTTGTGCTCTGCCTGGAGCTGTTTCCATATGA 721 TATAAAAAGCAAGTGTAGTATTCCATTACTATGTGGCTTAGGGATTTATTTGTTTTTTAAAATCAACCATGTTAGCTGGG 801 ATTAGACTCCCTACAGTCCTTCAATGGAAAAGTAACATTTAAAAATCCTTTGGGTAATTCGAATTACAGATTTAAAAGAG 881 CTTAAGATCTGGTGTTTTGTTAATGCTTCTGTTTATTCCAGAAGCATTAAGGTAACCCATTGCCAAGTATCATTCTTGCA 961 AATTATTCTTTTATATAACTGACCAGTGCTTAATAAAACAAGCAGGTACTTACAAATAATTACTGGCAGTAGGTTATAAT 1041 TGGTGGTTTAAAAATAACATTGGAATACAGGACTTGTTGCCAATTGGGTAATTTTCATTAGTTGTTTTGTTTGTTTTGAT 1121 TTGAAACCTGGAAATACAGTAAAATTTGACTGTTTAAAATGTTGGCCAAAAAAATCAAGATTTAATTTTTTTATTTGTAC 1201 TGAAAAACTAATCATAACTGTTAATTCTCAGCCATCTTTGAAGCTTGAAAGAAGAGTCTTTGGTATTTTGTAAACGTTAG 1281 CAGACTTTCCTGCCAGTGTCAGAAAATCCTATTTATGAATCCTGTCGGTATTCCTTGGTATCTGAAAAAAATACCAAATA 1361 GTACCATACATGAGTTATTTCTAAGTTTGAAAAATAAAAAGAAATTGCATCACACTAATTACAAAATACAAGTTCTGGAA 1441 AAAATATTTTTCTTCATTTTAAAACTTTTTTTTAACTAATAATAGCTTTGAAAGAAGAGGCTTAATTTGGGGGTGGTAAC 1521 TAAAATCAAAAGAAATGATTGACTTGAGGGTCTCTGTTTGGTAAGAATACATCATTAGCTTAAATAAGCAGCAGAAGGTT 1601 AGTTTTAATTATGTAGCTTCTGTTAATATTAAGTGTTTTTTGTCTGTTTTACCTCAATTTGAACAGATAAGTTTGCCTGC 1681 ATGCTGGACATGCCTCAGAACCCTGAATAGCCCGTACTAGATCTTGGGAACATGGATCTTAGAGTCACTTTGGAATAAGT 1761 TCTTATATAAATACCCCCAGCCTTTTGAGAACGGGGCTTGTTAAAGGACGCGTATGTAGGGCCCGTACCTACTGGCAGTT 1841 GGGTTCAGGGAAATGGGATTGACTTGGCCTTCAGGCTCCTTTGGTCATAATTTTAAAATATGGGAGTAGAAAACAACAAA 1921 GAATGGAATGGACTCTTAAAACAATGAAAGAGCATTTATCGTTTGTCCCTTGAATGTAGAATTTGTTTTTGATTTCATAA 2001 TTCTGCTGGTAAATGTGACAGTTAAAATGGTGCATTATGTATATATATTATAATTTAGAAATACCATTTTATAATTTTAC 2081 TATTCCAGGGTGACATAATGCATTTAAATTTGGGATTTGGGTGGAGTATTATGTTTAACTGGAGTTGTCAAGTATGAGTC 2161 CCTCAGGAAAAAAAAAAAATTCTGTTTTAAAAAGCAATCTGATTCTTAGCTCTTGAAACTATTGCTACTTAAATTTCCAA 2241 TAATTAAAAATTTAAAATTTTTAAATTAGAATTGCCAATACTTCTACATTTGAGAAGGGTTTTTTTAGAAATACATTTAG 2321 TAAAGTCCCCAAGACATTAGTCTTACATTTAAACTTTTTTCTTTAAAACATGGTTTTGGTGGTTAACTTTTACACAGTTC 2401 TGAGTACTGTTAATATCTGGAAAGTATCTTGAGATATCAGTGGAAAGCTAAACAGTCTAAATTAACATGAAATACTTCAT 2481 TTTGATTGAGAAAATAAAATCAGATTTTTTCAAAGTCAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | hESCs (WA-09) | ||||||
Disease | 10097.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine
... - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al. - Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
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Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Prostate Tissue | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
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PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A
... - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.). |
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miRNA-target interactions (Provided by authors) |
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Article |
- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al. - Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
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CLIP-seq Support 1 for dataset SRR359787 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | hESCs (WA-09) / 4-thiouridine, RNase T1 |
Location of target site | ENST00000260641.5 | 3UTR | AUGUUAGCUGGGAUUAGACUC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22012620 / SRX103431 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT085323 | MORC3 | MORC family CW-type zinc finger 3 | ![]() |
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2 | 2 | ||||||
MIRT089441 | STAMBP | STAM binding protein | ![]() |
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2 | 2 | ||||||
MIRT089456 | TET3 | tet methylcytosine dioxygenase 3 | ![]() |
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2 | 2 | ||||||
MIRT111856 | CCND1 | cyclin D1 | ![]() |
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2 | 2 | ||||||
MIRT184933 | ZNF268 | zinc finger protein 268 | ![]() |
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2 | 2 | ||||||
MIRT215288 | CREBRF | CREB3 regulatory factor | ![]() |
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2 | 2 | ||||||
MIRT237300 | LPP | LIM domain containing preferred translocation partner in lipoma | ![]() |
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2 | 2 | ||||||
MIRT238446 | MYO10 | myosin X | ![]() |
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2 | 4 | ||||||
MIRT273827 | RPL41 | ribosomal protein L41 | ![]() |
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2 | 2 | ||||||
MIRT282703 | HOOK1 | hook microtubule tethering protein 1 | ![]() |
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2 | 2 | ||||||
MIRT347970 | ZNF850 | zinc finger protein 850 | ![]() |
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2 | 2 | ||||||
MIRT371076 | KLF3 | Kruppel like factor 3 | ![]() |
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2 | 2 | ||||||
MIRT464339 | USP6NL | USP6 N-terminal like | ![]() |
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2 | 2 | ||||||
MIRT470034 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | ![]() |
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2 | 2 | ||||||
MIRT477506 | ELL2 | elongation factor for RNA polymerase II 2 | ![]() |
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2 | 2 | ||||||
MIRT482886 | CACNA2D3 | calcium voltage-gated channel auxiliary subunit alpha2delta 3 | ![]() |
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2 | 2 | ||||||
MIRT492606 | POLR3E | RNA polymerase III subunit E | ![]() |
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2 | 2 | ||||||
MIRT502294 | GNG12 | G protein subunit gamma 12 | ![]() |
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2 | 6 | ||||||
MIRT507600 | DCTN4 | dynactin subunit 4 | ![]() |
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2 | 4 | ||||||
MIRT510728 | SON | SON DNA binding protein | ![]() |
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2 | 6 | ||||||
MIRT514065 | KCNJ6 | potassium voltage-gated channel subfamily J member 6 | ![]() |
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2 | 8 | ||||||
MIRT519718 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 4 | ||||||
MIRT520890 | STRN | striatin | ![]() |
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2 | 2 | ||||||
MIRT521760 | PPIL1 | peptidylprolyl isomerase like 1 | ![]() |
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2 | 6 | ||||||
MIRT526874 | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | ![]() |
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2 | 2 | ||||||
MIRT530232 | WSB2 | WD repeat and SOCS box containing 2 | ![]() |
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2 | 2 | ||||||
MIRT532003 | ACTR2 | ARP2 actin related protein 2 homolog | ![]() |
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2 | 2 | ||||||
MIRT533371 | UBE2D4 | ubiquitin conjugating enzyme E2 D4 (putative) | ![]() |
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2 | 4 | ||||||
MIRT547106 | PIGW | phosphatidylinositol glycan anchor biosynthesis class W | ![]() |
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2 | 2 | ||||||
MIRT548189 | FOXA1 | forkhead box A1 | ![]() |
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2 | 2 | ||||||
MIRT552935 | VKORC1L1 | vitamin K epoxide reductase complex subunit 1 like 1 | ![]() |
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2 | 2 | ||||||
MIRT560085 | ZNF195 | zinc finger protein 195 | ![]() |
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2 | 2 | ||||||
MIRT561726 | PPP2CA | protein phosphatase 2 catalytic subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT562713 | ZNF415 | zinc finger protein 415 | ![]() |
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2 | 2 | ||||||
MIRT562761 | ZNF846 | zinc finger protein 846 | ![]() |
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2 | 2 | ||||||
MIRT564159 | ZNF117 | zinc finger protein 117 | ![]() |
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2 | 2 | ||||||
MIRT565673 | SETD5 | SET domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT565718 | SESN3 | sestrin 3 | ![]() |
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2 | 2 | ||||||
MIRT566026 | RFX1 | regulatory factor X1 | ![]() |
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2 | 2 | ||||||
MIRT569048 | ZNF655 | zinc finger protein 655 | ![]() |
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2 | 2 | ||||||
MIRT570367 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ![]() |
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2 | 2 | ||||||
MIRT570410 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | ![]() |
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2 | 2 | ||||||
MIRT570443 | TMEM189 | transmembrane protein 189 | ![]() |
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2 | 2 | ||||||
MIRT571738 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT575042 | Tpgs2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 4 | ||||||
MIRT614330 | ZDHHC22 | zinc finger DHHC-type containing 22 | ![]() |
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2 | 2 | ||||||
MIRT617629 | RAB3IP | RAB3A interacting protein | ![]() |
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2 | 2 | ||||||
MIRT621667 | UBE4B | ubiquitination factor E4B | ![]() |
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2 | 2 | ||||||
MIRT639906 | SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | ![]() |
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2 | 2 | ||||||
MIRT651436 | XRCC5 | X-ray repair cross complementing 5 | ![]() |
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2 | 2 | ||||||
MIRT683853 | ZNF208 | zinc finger protein 208 | ![]() |
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2 | 2 | ||||||
MIRT684841 | TPGS2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 5 | ||||||
MIRT689347 | ZNF83 | zinc finger protein 83 | ![]() |
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2 | 2 | ||||||
MIRT692492 | SPIN4 | spindlin family member 4 | ![]() |
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2 | 2 | ||||||
MIRT695711 | OLA1 | Obg like ATPase 1 | ![]() |
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2 | 2 | ||||||
MIRT698219 | TMEM248 | transmembrane protein 248 | ![]() |
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2 | 2 | ||||||
MIRT711560 | FAM20B | FAM20B, glycosaminoglycan xylosylkinase | ![]() |
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2 | 2 | ||||||
MIRT712867 | TMEM67 | transmembrane protein 67 | ![]() |
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2 | 2 | ||||||
MIRT722956 | TSPAN1 | tetraspanin 1 | ![]() |
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2 | 2 | ||||||
MIRT723622 | SOBP | sine oculis binding protein homolog | ![]() |
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2 | 2 | ||||||
MIRT724176 | ABCF2 | ATP binding cassette subfamily F member 2 | ![]() |
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2 | 2 | ||||||
MIRT755363 | LMBR1 | limb development membrane protein 1 | 3 | 1 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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