miRTarBase - #MIRT533371


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pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol UBE2D4   
Synonyms HBUCE1
Description ubiquitin conjugating enzyme E2 D4 (putative)
Transcript NM_015983   
Expression
Putative miRNA Targets on UBE2D4
3'UTR of UBE2D4
(miRNA target sites are highlighted)		 
>UBE2D4|NM_015983|3'UTR
   1 GTGCCTTGGAGGTTTTACATGAGACACTGTCCAAGAGAAGCTGGCAGAGAGGTCTTCCCTTAAAACTTTGGGCTGTTGGC
  81 TGAGCCATTCAAAGAGCATCATCTGTTCTTCAAACAAATGTTGGTCACCCACTCTCTCCAGCTGCAGCATGTTGGTGCCA
 161 TTTTCAGCAATTACGGCTTTGACAGTGCCACCTCTTTGATGCCAAATCAGCAACCATTGTTGTTATGATCTGCAGTCTTC
 241 CTGGTGACACTGGAATCTCTCTCTCTGCCGCCTCAGTTTGTCTGCTGGTCTCTTGGGGGGCCAGGCCCTGCACGTCTCTC
 321 CTACCCGGCCTCAAATGGTGCTGCTGCCCATGATGGTACCACACCAGGGCCTCAGCCTGGCCCCTCACCACATACCCTTT
 401 GCCTTTTAGAACTCAGTGCCATCCTGGGTGCCCAGGGCAGAGCAGGCTTTGTTCGCACCTCATCTGCTGCAGAACCACAT
 481 CCTGAGGAGTCTCAGCTTATCCTGGAGGGAATTGGGAACAGTGTCACTGGGAAGTGAAGGCCTAGCCCTGTGGCTTCCAC
 561 CAGTCTCCTCCTGCAGTGCCACGTGGTGGCATTTCTCGCCTCACACCAAGAAGCAGCAAGTGGAAAATTTCAGGATACAA
 641 AGCACATAACACCCCATAAGAGATGATTATGTTTTTAGAAGCAAGAGCAAAATTATGAAACCTCTAGAGATTTGGGTCAT
 721 GTTACTCCATTTGATGAAGATTCTCACTACCGCCCGCTCCTCCCATAGGAGCCTACACTAAGTCCAAGTGTGAGCCATTC
 801 ACAGACTAGAACACAAGGAGGGAGAGAGACTCTTAAACGTAAATAAAAATGCAATTCACTCACAACTCTAAATGATAATT
 881 GACATTTCAGCCTCTTTCTTTTAGGCAAAACAGAAGATACACACTATTAACAGTTATTTGAAGCCTTAAATTACAATAGC
 961 CTGTTAGGTGATCGGCTTTCTGCCTTGGCTTTCTGATGCAGCACATTTTAAGATTTGCCTTTAAAGCTTTGAGCCTTGAG
1041 ATTAGGTTAGTTAGGAAGAGGACAACAAAGGGAAGAGATTATTCTAATAAAACTTCCACAGAGGGAAGAAAATTGAGGAG
1121 CTTCAGATCTCTAAAGCCAAATTCAACCTGATCTTTCTAGGTTGGTTATAAAGCTGGTCCACTTCCAGGAAGTGATGTGT
1201 AGGTGAATAGGAACAAAAGGTGAAGAAGCAGTAAAACTGTGACCAAGTGGCCAGATGGGGCTTTTGCCGGCTGATTGAAA
1281 GGAAGTCTACAGACCTAACATAAGCAGTCAGCCAAAGGTGGCTGTGGGAGGTTGATTTCTTCCAGAAACTTCCAAGTTGT
1361 GGCTACAAATTTATTGCCAGATATTTTCCCACTGAGAATACTGAGGTTATTCACATAATCACTTCCTTAACAAAGGAAGA
1441 AGCACTTTTAACTTGGGCTGCATTCCCTTTGTGAGGGTCCACATTTAGGATCCTCCTGCTACCATAAGGCCCCTTTTGGG
1521 GTTCTTTGGGTGTGGCTGCATCTCACCATGTTGAGGATTGCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTAACACAGAGC
1601 CTTGCTCTGTCTCCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCAATTC
1681 TCCTGCCTCAGCCTCCCAAGTAGCCGGAATTACAGGCATGTGCCACCATGCTGGGCTAATTTTTGTATTTTTAGTGGAGA
1761 CGGTGTTTCACCATGTTGGCCAGGCTGTTCTTGAACTCCTGGCCTCAAGTGACCCGCCCACATTGGCCTCCCAAAGTGCT
1841 GGGATTACAGGCGTGAGCCCCCGTGCCCAGCAAGGATTGCTGTTTTAATTCTTGTATCTTCGTTGCTTCTTTGGTCTTTG
1921 CTTAAACAAAACAATAAAGCTTAATAGTTGGGGAGAATGCTGTTACCAGTGTCCTCTAGGAAGGCTGTTAGCATATGGCT
2001 CTACTGAGCAGCAGTGCCATCTGGTGCCTGAGATCATGTGCTTCAGGCAGTTGTCACACTGCATCTACAGCCAAGCATCA
2081 CAGAAACACTTCACTCATGTGGTCAGGGAAGGTGGGACTGATTCACATGTTAGAGACAGGTCAGATGGGAAAATTAAGGC
2161 CCAACTTGGTGTTGGGGAATAACCATACTCTGGTCTTTCAAGTGTAGTAGCTGATGATTCCCAAGAAACTGATGAATTTT
2241 CTGAGTCCAGACAAAATTTCCCCAAGCCTGCTCTCTCTGTTGGATATACATAATAGAGAAAGTCAAATCAGCCCTTTGGG
2321 GTTTGTGGTAAAAATTCACTCACCCATTGAAGCCTAAGGTGGCTTTGTACCTTCCAGATCTCTCAGCAAATCCCCTGGGC
2401 AGAAATGTCACCTGCTTGCCATGTCTTTGAGGGGTTCAGGTCAGCCTGGAGAACAGGCTCCTTAGGTCAAAAACCTTGTT
2481 TTAAGAGCCACTGTGGTACAGTCAATGTAACCCACTTGTGCAGAAGCCATGCTTCCAAGGAAGGTCTCAGGTTGACAACT
2561 AGACATCAAATCTGAGAAGCCAACTGTGGAGTAATGTGTTTTTTTCTCTGTGGACAAGAGTGATCAGAAAGGTGCTTGAT
2641 CTTGAACAATTGATCCATGATGAAAAAATGACCATTAGCTCTCCCCCAGAAGCGTCTGTGTTTGCTGAATGGAGCTGAGA
2721 TTTTGATCCGCTATCAGACTCCAGAAAGATCCAGGAGTTCCAAGAACATGGCAAAGAGTCAAAATCTTAGGACAAGGAAT
2801 TAAAATGCCAGAATGCAAATGTCCAACAGGCCTGGTAGCTCACAGCTATCAACACCCTAGAATTCCACACTGCCTCACTG
2881 CAGTTGCTCAAGGATGGGTATGTTTCTGTCTCTGAAATTCGGGAAAAAGCCTTAAGTGCCAGAGAAGGTGCTTCCAAGAC
2961 TGTCTGCAGAATTCCTTTCCTAGGGTCTGTCTCTGGTACCCAAAAGGGCAGAGAAGGAACCCTAAGATTAGCATAGAGCC
3041 ACTCATCTCTCCTCCCCTCCCCACCCCTTCTTCCCCTGCTTCCATTCCCCATGGCTCTCTCCTCTGACTGTGAAACACTT
3121 CCTCTCCAGCAGTGTTGGGAAAGTTCTGGACCTCTACTGGATCTAGCCATAAATGGTGGTCTTCAGAAAAATGGAGATTG
3201 TGGCTGCCAGCACCCACAAGACAGCAGCCTCATGCCATGCAGGCAGCAAGCCATCCTGAACAGCGTTCCTCCCAGAGTCT
3281 GTTTCCTCACCTGCTGTTCACTGGTGAGAGGAAAAGGGACTTGTTCTCCCTTGACCAGTTTTCTAGTTTTCCTGTTCCCA
3361 CCCTGGTCTTTGCCTGATGACAGAGAAACTTTCTAAAAAAAAACAAAAACAAAAGCTATAAAAAATCTGCAAAACACCCT
3441 AAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caCAC----GAGAGACCA----------GUUGGUAg 5'
            |||    ||||:|| |          ||||||| 
Target 5' caGTGCCACCTCTTTGATGCCAAATCAGCAACCATt 3'
 183 - 218 148.00 -16.90
2 
miRNA  3' cacACGAGAGACC--AGUUGGUAg 5'
             || | |: ||   :|||||| 
Target 5' actTGGTGTTGGGGAATAACCATa 3'
 2164 - 2187 133.00 -12.80
3 
miRNA  3' cacacGAGA-GACC-A-GUUGGUAg 5'
               |||| |||| | :|:|||| 
Target 5' tggacCTCTACTGGATCTAGCCATa 3'
 3147 - 3171 129.00 -17.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20075955 26 COSMIC
COSN30499841 97 COSMIC
COSN30154533 112 COSMIC
COSN30166828 112 COSMIC
COSN31511887 127 COSMIC
COSN30108135 161 COSMIC
COSN31580411 175 COSMIC
COSN30095183 328 COSMIC
COSN31553740 443 COSMIC
COSN30733162 580 COSMIC
COSN1349789 631 COSMIC
COSN20690003 643 COSMIC
COSN23240993 643 COSMIC
COSN1349790 676 COSMIC
COSN1349791 694 COSMIC
COSN1349792 731 COSMIC
COSN21429996 756 COSMIC
COSN25928949 840 COSMIC
COSN24147652 988 COSMIC
COSN2224125 1011 COSMIC
COSN6882611 1352 COSMIC
COSN28968752 1413 COSMIC
COSN6882612 1854 COSMIC
COSN30023092 1866 COSMIC
COSN8023198 2225 COSMIC
COSN8023199 2237 COSMIC
COSN21809576 2291 COSMIC
COSN8570750 2434 COSMIC
COSN23067785 2506 COSMIC
COSN14450473 2682 COSMIC
COSN22981276 3014 COSMIC
COSN19441322 3153 COSMIC
COSN22109646 3255 COSMIC
COSN8570751 3309 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748496899 2 dbSNP
rs967071730 4 dbSNP
rs772232564 9 dbSNP
rs1304604659 13 dbSNP
rs978303529 15 dbSNP
rs377215582 17 dbSNP
rs1254018014 20 dbSNP
rs547993553 21 dbSNP
rs1288628454 25 dbSNP
rs989669834 28 dbSNP
rs760815205 30 dbSNP
rs766435341 33 dbSNP
rs776638074 36 dbSNP
rs1358847904 38 dbSNP
rs759497023 41 dbSNP
rs1294273085 45 dbSNP
rs562763445 49 dbSNP
rs1339251465 50 dbSNP
rs752479303 53 dbSNP
rs1415936513 54 dbSNP
rs1230007507 76 dbSNP
rs948112779 83 dbSNP
rs1046480573 89 dbSNP
rs974043934 96 dbSNP
rs577766932 109 dbSNP
rs1465799266 114 dbSNP
rs112209777 122 dbSNP
rs1045398 133 dbSNP
rs1044427632 154 dbSNP
rs879230938 158 dbSNP
rs907168172 165 dbSNP
rs888389231 171 dbSNP
rs1255315894 175 dbSNP
rs1429072832 176 dbSNP
rs1005329109 177 dbSNP
rs1039913482 178 dbSNP
rs899681574 185 dbSNP
rs998304733 187 dbSNP
rs560321050 190 dbSNP
rs1029421216 193 dbSNP
rs527357016 200 dbSNP
rs549043981 204 dbSNP
rs967026066 212 dbSNP
rs1031239052 217 dbSNP
rs998559468 217 dbSNP
rs1311152211 218 dbSNP
rs560856634 222 dbSNP
rs1397627307 225 dbSNP
rs938782566 227 dbSNP
rs118167064 229 dbSNP
rs112198998 234 dbSNP
rs1407933776 236 dbSNP
rs1165764749 245 dbSNP
rs1459447324 249 dbSNP
rs1366671213 254 dbSNP
rs533432428 256 dbSNP
rs758123492 258 dbSNP
rs1012141067 264 dbSNP
rs969593826 266 dbSNP
rs1363219769 270 dbSNP
rs1273355317 271 dbSNP
rs1043184040 295 dbSNP
rs1215058664 295 dbSNP
rs1384385407 297 dbSNP
rs1294114075 298 dbSNP
rs1307269113 310 dbSNP
rs982599262 313 dbSNP
rs1224579724 314 dbSNP
rs900776985 315 dbSNP
rs1444952051 319 dbSNP
rs537676784 326 dbSNP
rs193280664 327 dbSNP
rs1027950360 328 dbSNP
rs1388632738 346 dbSNP
rs1162660172 348 dbSNP
rs955214962 349 dbSNP
rs929960920 355 dbSNP
rs1156621360 365 dbSNP
rs1008012837 374 dbSNP
rs1438811503 377 dbSNP
rs1015748046 392 dbSNP
rs1047081462 393 dbSNP
rs538875380 397 dbSNP
rs973919674 401 dbSNP
rs919726939 404 dbSNP
rs1240138384 420 dbSNP
rs1200518254 426 dbSNP
rs1449413861 427 dbSNP
rs549548833 434 dbSNP
rs111498272 441 dbSNP
rs969968864 444 dbSNP
rs1384479459 447 dbSNP
rs1442271183 448 dbSNP
rs547569597 452 dbSNP
rs758178204 455 dbSNP
rs1039626421 457 dbSNP
rs1385526756 459 dbSNP
rs1288693482 462 dbSNP
rs928659393 463 dbSNP
rs1353412631 466 dbSNP
rs1327384724 469 dbSNP
rs1315710706 470 dbSNP
rs1343819302 471 dbSNP
rs1433270145 472 dbSNP
rs1304498440 485 dbSNP
rs1321845203 485 dbSNP
rs1382658126 487 dbSNP
rs1329476209 489 dbSNP
rs565864980 490 dbSNP
rs756839575 494 dbSNP
rs780418483 495 dbSNP
rs536344595 496 dbSNP
rs749438828 497 dbSNP
rs554584885 498 dbSNP
rs576370561 499 dbSNP
rs1362414666 508 dbSNP
rs1053236068 509 dbSNP
rs913327530 510 dbSNP
rs184338139 513 dbSNP
rs556209213 515 dbSNP
rs1459904354 522 dbSNP
rs1184959157 525 dbSNP
rs1174032078 526 dbSNP
rs1386623487 531 dbSNP
rs1243227793 535 dbSNP
rs902956494 543 dbSNP
rs1193280461 544 dbSNP
rs751243911 547 dbSNP
rs150894469 548 dbSNP
rs1266000893 554 dbSNP
rs1215049082 565 dbSNP
rs1488207849 565 dbSNP
rs998507324 566 dbSNP
rs1221238254 568 dbSNP
rs1343147346 569 dbSNP
rs369426930 583 dbSNP
rs754268379 584 dbSNP
rs756656390 587 dbSNP
rs1051960930 590 dbSNP
rs890826743 598 dbSNP
rs1276269667 599 dbSNP
rs1361873490 600 dbSNP
rs1405868629 610 dbSNP
rs1194979137 611 dbSNP
rs1008289182 612 dbSNP
rs1285610606 613 dbSNP
rs35964340 622 dbSNP
rs201003416 623 dbSNP
rs1412476296 647 dbSNP
rs1401090855 654 dbSNP
rs545249289 657 dbSNP
rs1168085224 660 dbSNP
rs1478540436 664 dbSNP
rs1420833225 665 dbSNP
rs780357541 666 dbSNP
rs1045439 677 dbSNP
rs1238493384 685 dbSNP
rs1213821700 705 dbSNP
rs1441003842 706 dbSNP
rs1278250745 707 dbSNP
rs1026822241 708 dbSNP
rs1320174196 712 dbSNP
rs1487931459 716 dbSNP
rs1218025239 720 dbSNP
rs1356015932 721 dbSNP
rs1011543702 751 dbSNP
rs1222897431 752 dbSNP
rs1339628961 753 dbSNP
rs1270736559 756 dbSNP
rs969876803 757 dbSNP
rs980048735 759 dbSNP
rs1479359659 762 dbSNP
rs928529327 763 dbSNP
rs1023926330 766 dbSNP
rs1461474958 770 dbSNP
rs1415188728 771 dbSNP
rs1184090196 779 dbSNP
rs969958287 801 dbSNP
rs1190253783 805 dbSNP
rs765514794 810 dbSNP
rs1179554576 814 dbSNP
rs1459266229 815 dbSNP
rs76982206 816 dbSNP
rs1198124884 819 dbSNP
rs140210321 820 dbSNP
rs1360392682 821 dbSNP
rs1425882475 822 dbSNP
rs982847062 825 dbSNP
rs758475559 827 dbSNP
rs909846712 830 dbSNP
rs947476942 836 dbSNP
rs145336686 839 dbSNP
rs748423069 840 dbSNP
rs975727761 853 dbSNP
rs147662697 855 dbSNP
rs1441072056 864 dbSNP
rs1167604619 873 dbSNP
rs1404079291 874 dbSNP
rs1375810613 879 dbSNP
rs1413627916 880 dbSNP
rs372497157 885 dbSNP
rs1159629935 893 dbSNP
rs932140383 895 dbSNP
rs1441886164 905 dbSNP
rs1051992652 907 dbSNP
rs1178231325 910 dbSNP
rs890719763 912 dbSNP
rs1248516100 917 dbSNP
rs940922571 925 dbSNP
rs1222089529 926 dbSNP
rs1450969726 934 dbSNP
rs1286601242 941 dbSNP
rs1306419810 945 dbSNP
rs921227331 948 dbSNP
rs142369141 958 dbSNP
rs933797917 961 dbSNP
rs115498935 969 dbSNP
rs1369175695 971 dbSNP
rs1001589345 974 dbSNP
rs896776876 974 dbSNP
rs995293957 975 dbSNP
rs1054215478 976 dbSNP
rs1378820186 994 dbSNP
rs1158333011 995 dbSNP
rs1433998893 1009 dbSNP
rs892801173 1014 dbSNP
rs1189576738 1017 dbSNP
rs1012625323 1019 dbSNP
rs1263884184 1046 dbSNP
rs1024288726 1049 dbSNP
rs1026727751 1053 dbSNP
rs905722386 1057 dbSNP
rs375606434 1058 dbSNP
rs1220562497 1080 dbSNP
rs1233037962 1089 dbSNP
rs1001349511 1090 dbSNP
rs772183185 1095 dbSNP
rs960237178 1101 dbSNP
rs1004217277 1105 dbSNP
rs1035128425 1119 dbSNP
rs1279429842 1121 dbSNP
rs1379121599 1132 dbSNP
rs1444767849 1139 dbSNP
rs1166005765 1147 dbSNP
rs1361139825 1149 dbSNP
rs988705759 1156 dbSNP
rs1432720138 1159 dbSNP
rs951550720 1159 dbSNP
rs982794834 1165 dbSNP
rs1017007686 1167 dbSNP
rs1262296089 1168 dbSNP
rs773403118 1174 dbSNP
rs968685181 1185 dbSNP
rs978845578 1187 dbSNP
rs1405072837 1198 dbSNP
rs1329989289 1201 dbSNP
rs1484083409 1207 dbSNP
rs922003221 1215 dbSNP
rs1253928826 1217 dbSNP
rs532645924 1218 dbSNP
rs1318081530 1220 dbSNP
rs1259446070 1227 dbSNP
rs1440248452 1230 dbSNP
rs963031375 1238 dbSNP
rs547633001 1244 dbSNP
rs565927716 1248 dbSNP
rs1383593492 1255 dbSNP
rs932042790 1260 dbSNP
rs988056627 1269 dbSNP
rs975460573 1270 dbSNP
rs1381759363 1273 dbSNP
rs189619891 1276 dbSNP
rs912027579 1278 dbSNP
rs1248343958 1281 dbSNP
rs933893052 1289 dbSNP
rs940940785 1294 dbSNP
rs1422853544 1300 dbSNP
rs1188136410 1303 dbSNP
rs1425375004 1307 dbSNP
rs1253810806 1316 dbSNP
rs1036613004 1317 dbSNP
rs1457938328 1319 dbSNP
rs1316991194 1324 dbSNP
rs765224839 1325 dbSNP
rs181120049 1328 dbSNP
rs930951616 1335 dbSNP
rs1273485119 1339 dbSNP
rs1054205623 1342 dbSNP
rs1311050391 1350 dbSNP
rs149797143 1353 dbSNP
rs905625660 1354 dbSNP
rs1001251426 1358 dbSNP
rs1044038546 1360 dbSNP
rs906882769 1363 dbSNP
rs537068831 1364 dbSNP
rs1035935332 1377 dbSNP
rs1056649246 1382 dbSNP
rs1366578094 1387 dbSNP
rs1162729391 1394 dbSNP
rs1461375470 1396 dbSNP
rs1184911372 1401 dbSNP
rs1381835242 1406 dbSNP
rs895648503 1410 dbSNP
rs1176366181 1416 dbSNP
rs887268050 1422 dbSNP
rs1010605926 1439 dbSNP
rs1020189770 1459 dbSNP
rs1235336868 1461 dbSNP
rs968715957 1468 dbSNP
rs978752201 1477 dbSNP
rs17172258 1503 dbSNP
rs1422065867 1509 dbSNP
rs1264157617 1525 dbSNP
rs553541236 1528 dbSNP
rs953470593 1533 dbSNP
rs145762076 1536 dbSNP
rs912083909 1545 dbSNP
rs1335308586 1550 dbSNP
rs1454594272 1555 dbSNP
rs962228484 1558 dbSNP
rs1388520091 1561 dbSNP
rs1302449032 1562 dbSNP
rs1200407957 1563 dbSNP
rs1214829615 1563 dbSNP
rs1235576146 1563 dbSNP
rs1257782271 1563 dbSNP
rs1265938637 1563 dbSNP
rs1275611604 1563 dbSNP
rs1282642318 1563 dbSNP
rs1288584417 1563 dbSNP
rs1296123332 1563 dbSNP
rs1329387190 1563 dbSNP
rs1350270341 1563 dbSNP
rs1362323681 1563 dbSNP
rs1377779384 1563 dbSNP
rs1400523449 1563 dbSNP
rs1420121962 1563 dbSNP
rs1430900528 1563 dbSNP
rs1488858860 1563 dbSNP
rs774290334 1563 dbSNP
rs1399852782 1564 dbSNP
rs1338585965 1565 dbSNP
rs1402493836 1588 dbSNP
rs1464137420 1591 dbSNP
rs972754698 1591 dbSNP
rs1447159523 1592 dbSNP
rs1270749178 1594 dbSNP
rs920827631 1608 dbSNP
rs1191515577 1609 dbSNP
rs148865575 1622 dbSNP
rs1256958765 1623 dbSNP
rs955566804 1626 dbSNP
rs1262608305 1629 dbSNP
rs1219262046 1630 dbSNP
rs1323831063 1636 dbSNP
rs1048100906 1637 dbSNP
rs1429824598 1640 dbSNP
rs1260745772 1644 dbSNP
rs1335851737 1649 dbSNP
rs1441384425 1658 dbSNP
rs1194498811 1675 dbSNP
rs986710105 1678 dbSNP
rs1474591100 1683 dbSNP
rs926907839 1684 dbSNP
rs1170778305 1685 dbSNP
rs143558666 1687 dbSNP
rs763928167 1697 dbSNP
rs572272253 1700 dbSNP
rs1166634362 1705 dbSNP
rs1056877222 1706 dbSNP
rs184190294 1707 dbSNP
rs1010054256 1717 dbSNP
rs1189985148 1736 dbSNP
rs1460157867 1747 dbSNP
rs1242722171 1757 dbSNP
rs1401420022 1760 dbSNP
rs1199369782 1762 dbSNP
rs1318885105 1763 dbSNP
rs188966804 1766 dbSNP
rs747080630 1774 dbSNP
rs1213913288 1784 dbSNP
rs1041919867 1787 dbSNP
rs1285745099 1797 dbSNP
rs1445454681 1809 dbSNP
rs757270588 1814 dbSNP
rs1397850498 1816 dbSNP
rs138101443 1817 dbSNP
rs1345709117 1822 dbSNP
rs1327504023 1823 dbSNP
rs1000034713 1824 dbSNP
rs111898359 1826 dbSNP
rs1409912965 1828 dbSNP
rs576072169 1833 dbSNP
rs1165398472 1845 dbSNP
rs1443117385 1849 dbSNP
rs751349008 1854 dbSNP
rs1009429990 1857 dbSNP
rs1231234392 1859 dbSNP
rs780964368 1863 dbSNP
rs1452113264 1868 dbSNP
rs1243562305 1881 dbSNP
rs537053775 1881 dbSNP
rs201501401 1885 dbSNP
rs756990066 1890 dbSNP
rs1216291715 1894 dbSNP
rs1241854487 1895 dbSNP
rs962546084 1902 dbSNP
rs1465304267 1903 dbSNP
rs1436528633 1907 dbSNP
rs887383672 1909 dbSNP
rs1351004153 1922 dbSNP
rs1326078557 1929 dbSNP
rs1423170019 1937 dbSNP
rs1004322206 1941 dbSNP
rs1159536781 1947 dbSNP
rs972275810 1947 dbSNP
rs920727444 1954 dbSNP
rs952277474 1963 dbSNP
rs1038470989 1970 dbSNP
rs1197521966 1981 dbSNP
rs981018860 1994 dbSNP
rs543079851 1996 dbSNP
rs564895009 1999 dbSNP
rs1220155132 2002 dbSNP
rs955401103 2013 dbSNP
rs1286493195 2020 dbSNP
rs1008257905 2026 dbSNP
rs1314800968 2041 dbSNP
rs1305795998 2046 dbSNP
rs1219360820 2061 dbSNP
rs1160388314 2065 dbSNP
rs1034522538 2067 dbSNP
rs1403620632 2068 dbSNP
rs1345367050 2079 dbSNP
rs1190196080 2097 dbSNP
rs529248732 2107 dbSNP
rs749952582 2115 dbSNP
rs541337319 2121 dbSNP
rs1417824854 2128 dbSNP
rs1297553115 2132 dbSNP
rs937011029 2144 dbSNP
rs1158618339 2153 dbSNP
rs1415179525 2165 dbSNP
rs1406610924 2170 dbSNP
rs1197294544 2173 dbSNP
rs1427340559 2173 dbSNP
rs1480073370 2174 dbSNP
rs1263765390 2176 dbSNP
rs1298651534 2185 dbSNP
rs1330160278 2196 dbSNP
rs559573979 2200 dbSNP
rs1210378372 2202 dbSNP
rs1313497273 2207 dbSNP
rs181655770 2208 dbSNP
rs78675819 2209 dbSNP
rs1350916637 2213 dbSNP
rs187120915 2214 dbSNP
rs1279334987 2230 dbSNP
rs1384323887 2240 dbSNP
rs531029374 2244 dbSNP
rs1288571707 2270 dbSNP
rs938331871 2278 dbSNP
rs1408489114 2281 dbSNP
rs1047411859 2284 dbSNP
rs76771676 2285 dbSNP
rs1208437210 2291 dbSNP
rs141091571 2297 dbSNP
rs1172698661 2299 dbSNP
rs1426583616 2301 dbSNP
rs534968748 2302 dbSNP
rs889143944 2305 dbSNP
rs1039028818 2307 dbSNP
rs1202510857 2316 dbSNP
rs898657268 2321 dbSNP
rs780724854 2325 dbSNP
rs1439220795 2330 dbSNP
rs749856365 2348 dbSNP
rs1019339387 2353 dbSNP
rs769427945 2354 dbSNP
rs1295310350 2360 dbSNP
rs1229206357 2372 dbSNP
rs891234089 2377 dbSNP
rs1008331552 2379 dbSNP
rs1452051849 2382 dbSNP
rs993950943 2393 dbSNP
rs3812252 2394 dbSNP
rs1299878382 2404 dbSNP
rs1460419733 2410 dbSNP
rs1372368208 2435 dbSNP
rs1165260158 2438 dbSNP
rs952184654 2441 dbSNP
rs1383053819 2447 dbSNP
rs1182564346 2451 dbSNP
rs1457868590 2452 dbSNP
rs981051493 2456 dbSNP
rs1193500682 2465 dbSNP
rs1021993028 2466 dbSNP
rs1251194307 2474 dbSNP
rs1378829563 2476 dbSNP
rs969912793 2476 dbSNP
rs1222830950 2494 dbSNP
rs1389514580 2494 dbSNP
rs1391577901 2496 dbSNP
rs1245506900 2500 dbSNP
rs1330531893 2506 dbSNP
rs1373996732 2508 dbSNP
rs1033914190 2512 dbSNP
rs980363711 2517 dbSNP
rs1395714675 2518 dbSNP
rs1294019312 2519 dbSNP
rs78004914 2540 dbSNP
rs992522252 2541 dbSNP
rs959753644 2544 dbSNP
rs983182715 2549 dbSNP
rs536484585 2555 dbSNP
rs1439923607 2567 dbSNP
rs916865584 2568 dbSNP
rs1365139224 2580 dbSNP
rs945816263 2583 dbSNP
rs1417975443 2587 dbSNP
rs1243010819 2599 dbSNP
rs1210950017 2600 dbSNP
rs144918742 2607 dbSNP
rs1290065015 2617 dbSNP
rs1222130267 2631 dbSNP
rs1354729368 2635 dbSNP
rs925820763 2639 dbSNP
rs117591249 2645 dbSNP
rs543495984 2650 dbSNP
rs191902937 2651 dbSNP
rs891320653 2658 dbSNP
rs1302341763 2663 dbSNP
rs1343491964 2663 dbSNP
rs77756953 2664 dbSNP
rs1386743874 2666 dbSNP
rs1053203913 2675 dbSNP
rs1452506339 2677 dbSNP
rs944591768 2679 dbSNP
rs1200892296 2682 dbSNP
rs1040378714 2684 dbSNP
rs1243624941 2688 dbSNP
rs897818728 2691 dbSNP
rs1425517766 2694 dbSNP
rs747144398 2695 dbSNP
rs1264175426 2699 dbSNP
rs1027728629 2701 dbSNP
rs1203611352 2712 dbSNP
rs1350152730 2712 dbSNP
rs1367652936 2714 dbSNP
rs1462356067 2715 dbSNP
rs1021522821 2717 dbSNP
rs1225384259 2721 dbSNP
rs887971212 2723 dbSNP
rs1002392828 2730 dbSNP
rs1034237112 2731 dbSNP
rs1327972129 2732 dbSNP
rs960998527 2733 dbSNP
rs1315850254 2741 dbSNP
rs1381318705 2748 dbSNP
rs1402394986 2756 dbSNP
rs992778684 2764 dbSNP
rs1336845909 2770 dbSNP
rs550997524 2771 dbSNP
rs967438937 2782 dbSNP
rs1035908975 2786 dbSNP
rs977167829 2791 dbSNP
rs559638425 2792 dbSNP
rs1312701798 2796 dbSNP
rs1243922557 2802 dbSNP
rs1446668883 2802 dbSNP
rs574779060 2803 dbSNP
rs77931399 2812 dbSNP
rs935727909 2827 dbSNP
rs985940611 2835 dbSNP
rs1205703464 2842 dbSNP
rs1327379607 2852 dbSNP
rs1460010808 2862 dbSNP
rs910343130 2879 dbSNP
rs1262503087 2882 dbSNP
rs944679647 2883 dbSNP
rs983128377 2896 dbSNP
rs1341311269 2898 dbSNP
rs1040686947 2903 dbSNP
rs1226374645 2905 dbSNP
rs1256328495 2909 dbSNP
rs897856136 2912 dbSNP
rs776671195 2916 dbSNP
rs929274637 2921 dbSNP
rs1204338338 2922 dbSNP
rs962996883 2923 dbSNP
rs542102004 2924 dbSNP
rs1404720365 2931 dbSNP
rs1265047725 2934 dbSNP
rs1336715557 2941 dbSNP
rs1482344720 2948 dbSNP
rs1180032519 2951 dbSNP
rs1255467110 2952 dbSNP
rs973507536 2957 dbSNP
rs1459285620 2960 dbSNP
rs1049068065 2966 dbSNP
rs1185648310 2979 dbSNP
rs1442914384 2987 dbSNP
rs1242619970 2988 dbSNP
rs1205229680 2990 dbSNP
rs1439528463 2994 dbSNP
rs1270742182 2997 dbSNP
rs1195063446 3001 dbSNP
rs1359849733 3010 dbSNP
rs762920426 3011 dbSNP
rs1243304177 3018 dbSNP
rs1381512435 3033 dbSNP
rs921628104 3042 dbSNP
rs1195594917 3045 dbSNP
rs1420963267 3047 dbSNP
rs1356839477 3051 dbSNP
rs1464809017 3052 dbSNP
rs182601933 3055 dbSNP
rs1360371062 3057 dbSNP
rs185781127 3058 dbSNP
rs552642233 3065 dbSNP
rs1302706299 3066 dbSNP
rs1366566563 3067 dbSNP
rs866387131 3074 dbSNP
rs544066580 3082 dbSNP
rs564543328 3088 dbSNP
rs896641787 3093 dbSNP
rs1013870836 3098 dbSNP
rs1384803663 3104 dbSNP
rs1021610087 3105 dbSNP
rs967039628 3107 dbSNP
rs1471188987 3123 dbSNP
rs1231147907 3125 dbSNP
rs1180997874 3126 dbSNP
rs998494874 3129 dbSNP
rs14176 3153 dbSNP
rs1490469362 3154 dbSNP
rs1032610623 3156 dbSNP
rs944222854 3159 dbSNP
rs1219895471 3160 dbSNP
rs761447726 3161 dbSNP
rs1358312466 3162 dbSNP
rs1276731106 3180 dbSNP
rs985840987 3182 dbSNP
rs528510814 3185 dbSNP
rs947394498 3199 dbSNP
rs966259564 3200 dbSNP
rs1285493887 3229 dbSNP
rs1346619918 3238 dbSNP
rs1310511551 3241 dbSNP
rs976050258 3242 dbSNP
rs547000086 3247 dbSNP
rs919187934 3254 dbSNP
rs929181180 3265 dbSNP
rs1255280941 3266 dbSNP
rs1486167747 3289 dbSNP
rs905882170 3304 dbSNP
rs1049101187 3312 dbSNP
rs1405870995 3319 dbSNP
rs1158008840 3321 dbSNP
rs1480725834 3330 dbSNP
rs1001818190 3333 dbSNP
rs1197072515 3347 dbSNP
rs767229876 3362 dbSNP
rs1242407184 3387 dbSNP
rs1056984038 3395 dbSNP
rs774051779 3395 dbSNP
rs545019580 3396 dbSNP
rs1282941872 3400 dbSNP
rs114998620 3411 dbSNP
rs534447239 3411 dbSNP
rs1181228491 3416 dbSNP
rs1218470545 3418 dbSNP
rs1364946680 3420 dbSNP
rs536544857 3420 dbSNP
rs1367344345 3428 dbSNP
rs1055608887 3436 dbSNP
rs963069867 3439 dbSNP
rs896679994 3440 dbSNP
rs1317761756 3441 dbSNP
rs1470331788 3441 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cacacgagAGACCAGUUGGUAg 5'
                  || |  ||||||| 
Target 5' ------aaUCAG--CAACCAUu 3'
 		1 - 14
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 51619.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cacacgagAGACCAGUUGGUAg 5'
                  || |  ||||||| 
Target 5' -----aaaUCAG--CAACCAUu 3'
 		1 - 15
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000222402.3 | 3UTR | AAUCAGCAACCAUUGUUGUUAUGAUCUGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000222402.3 | 3UTR | AAAUCAGCAACCAUUGUUGUUAUGAUCUGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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