miRTarBase - #MIRT533407


—
pre-miRNA Information
pre-miRNA hsa-mir-6509   
Genomic Coordinates chr7: 135206994 - 135207078
Description Homo sapiens miR-6509 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6509-3p
Sequence 52| UUCCACUGCCACUACCUAAUUU |73
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778601614 1 dbSNP
rs754554776 3 dbSNP
rs767798995 3 dbSNP
rs145322812 4 dbSNP
rs773941257 5 dbSNP
rs768273593 9 dbSNP
rs984565062 12 dbSNP
rs748872915 13 dbSNP
rs774861125 14 dbSNP
rs13241975 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TXLNG   
Synonyms CXorf15, ELRG, FIAT, LSR5, TXLNGX
Description taxilin gamma
Transcript NM_001168683   
Other Transcripts NM_018360   
Expression
Putative miRNA Targets on TXLNG
3'UTR of TXLNG
(miRNA target sites are highlighted)		 
>TXLNG|NM_001168683|3'UTR
   1 GATGAGGTGTGATCACTGTATTGAGAGATATATTTTGTGTATAACTTTCTCTGTTAGTAGTTAACTATTGGTTTTGTGGT
  81 GAAAATTTTCTTACTTTTTCTACCATATCTGTATTTTCTTAGAACTACTGGACTTATGTGGTACAGGAGGCTGCTTAGCA
 161 GTTTTGAATAGTTTAATCTATAAATTTTCCTCAGCTGTGTTGCACATCAGCCTCGTTCTCCCTCCACTGGAATGCATGTG
 241 TTCATTGCCTTGTCCTTTCTCTCCCTGCTCCTTGCACATTATCATCCTAATGAAAATTTCACTGACAGGGCCGACCATTA
 321 CAAGGGAACTTTGTTCTGACGATGGTTCCTTGATGTGAAAACAATATTAATTTAAACGTCTTAGCCCCCCCCCCCATAAT
 401 ATTATTCAGAAAAACAAAATACCAAGGCGATTAGTTTTGTCTAATAACCCATTTAAATGCCAAGTAAAAATAAAACTCCT
 481 AGTGTTGGGTCAGAAGCATATTTGATTGAAATTAGCTTTTTGAAAACATTTATATCTCGGGACAAATTGAGATGGCCACA
 561 TGCCTAGAATCCTAAGTTTCGGCAGAATATGTATATAAAGATGTCACTTGTGGACAAAATAGTACATAGAGGCAAATCAC
 641 TAGACAAATAAGCTTAGTGTTTACGTGACTGAACAGTCATCCTGCTTTGGTTTCAGGTGTGGGATTTGGACCATGAGGGG
 721 CTCCCGTAGAGGATGGCGGTTTGTGTTTGATTCTGATTTGGGATTTCAGTACATATTCTCCACTTCCCATAGAAGGCCAC
 801 TTATTCTTTGAAAACTGGTGTTCATGTTTGCCGTTCAATGAAGTCCCTTGTCAAAGACAAGGACGGTCAATTCACGTGTC
 881 ACTTTCACTAGGCAGAAGTTTCTCCAATACCTTCTGGCTACTTGAAAGTTACTACAAAAATTCCACCAGCAAAGTACTCC
 961 AGGTTTTTCAAAAGGGAATTTTCATTATGGATCAGTACCAACCGAAATTGATTTTCATTTCCAAAACAAACACTGGCACC
1041 AACATTTTTACTTTGGGAAGACTTGGCAGAGTGTTAGTCATGATCTGTTACTTACGTGTTCAGTCTGTTTTCTCACCCCC
1121 TTCTTAGTTACCATCTCTTTTTTAAGAAGAAAAAAGAAAAGCCACAGTATTATCAAGGTCTCTACACTTGGACTGGGGGA
1201 AAATTTGAAATTAAGCACATAACTTTTGAATTAGTTCTTTGTTTCAATGTTGAATGTGGCGCAGTTATGCAGATGATTAA
1281 TCAGGCTGCACTGATGGAAGTTTTGACTTTGTCCCTGGTATAATTTGCATTGAAATGCTTTATGAAATAAAAGGTTCTAC
1361 TAGAACTGATGTTAGCACATTCCACTGAGCAAAACTATCAGACTGACACTTGTTAAATTGCTTACTGGACTGAATAAACT
1441 CTGTTTTGTCCAGTTAAAAGGGTTTTCTCTTTGTTACAAGTGTTATTTGTAAAGTCCTGTCACATTCATGGTCGAAACTG
1521 GGTTGAAAGAATTGAAAATTGTCCAACAGATAGATAGATAGGAAACCGCCTGGAGTGGAGGAGGGTTGTATCTAAGCCTC
1601 CACTATCAGTCATGTTAATTCAAGGGGCCACAGTGGAGGAAAATAAATCCACAAAGTAGATTATCTAATTACCATCAAAA
1681 TGAGTCAGAAGCAAAAAACACCACCCTCCAACAGCCTCTTAGGAGTACACCCTGTTCTGCTACTAAAATACTAGACTCAT
1761 TTCCCTGGTGGTGGGGGGGAATGCAGGTATAGATCAGAAATATAATCCACCTTAAAATTAGTACTAATGATCACATTATT
1841 TCACAAGAACTCTGCTGGATGTACAGCTCTTAACATTTTATTAAGCCATTTGTGTAGCCCACCACGTTTCTTTGTGGTGC
1921 TTGTCCTGTGTGGAAGATTGTAAATCTTGGGCCTGTTGCATACTTCCAAGGGCTTTAAAGCAATGTGATTAACAGTACTT
2001 GGCCTGCTGCTTTTGGCTTACTTTGTATTTTTAGCTAGATGCTATTATAGTGTTGAAAGGATATGGATTCTGTCTGGGAT
2081 GCATTTGTTGTCCTTTCAGAACCCTTCCTCCCATTACCCTGTGAATAAAAACAAATGGGACCCCCTGAGAAGGACATCTT
2161 CCTACAGTGATCACCTCACCAGCCCAGTGTTGTGGCTTTGTAGCGCACCCCGTATCTACCATATTCTAGAACACTGTAAT
2241 GCTACTAGGCTGGCCCAGAAAAGGTTTAAATGTTGAATTCACTTAAATTGCAATTGTTGCACCATCATGGAATCGTGATG
2321 TGTATTATTTATATTGGCGGTGGACTCCAAGGTGTAGAGAAAACTTGGGTCTTGGGTAATATGGACCATTTCATCCTCAG
2401 ACTTGTTAGGAGTACATTTCTTGGTCTTGAGACCAGTATTTTTCAGTTATGTATGCAACTGCCTTTATTACACCTGGTTA
2481 TCACAATTCAATTCTCAGGTGTTGCAGAAAAATCTACCTCTTTCAGACTGTAGATGGAAATAACTGTGAAAAAAATGATG
2561 CAGATATCTTCTAGTTTGTGCTAAACACACTGCTTTATTTTTACAGCCCACGTCTTTCATGAGGATACGAATTGTTAAGA
2641 GGCAGTCTCGTTTTGCTTTTCAAAGACATTTTGTAGAGATTTTTCACTAATGTGAATCTGATTTTATCTACTTGATTCTG
2721 TATAGATTAAGTAAATATGTATGATAAACTTAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuuAAUCCAUCACCGUCACCUu 5'
             |||  || ||||:||||| 
Target 5' tatTTA--TATTGGCGGTGGAc 3'
 2326 - 2345 151.00 -15.20
2 
miRNA  3' uuUAAUCCA--UCACC---GUCACCUu 5'
            :|||  |  || ||   ||||||| 
Target 5' atGTTAATTCAAGGGGCCACAGTGGAg 3'
 1612 - 1638 150.00 -14.30
3 
miRNA  3' uuuaauccaucaccgUCACCUu 5'
                         |||||| 
Target 5' taggaaaccgcctggAGTGGAg 3'
 1559 - 1580 120.00 -13.00
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1332588305 2 dbSNP
rs757812417 4 dbSNP
rs779180594 7 dbSNP
rs73630570 8 dbSNP
rs1408453615 10 dbSNP
rs775119633 12 dbSNP
rs1436943505 14 dbSNP
rs1336628649 16 dbSNP
rs1327336441 18 dbSNP
rs1287858522 19 dbSNP
rs768032246 22 dbSNP
rs375328504 23 dbSNP
rs1278250518 26 dbSNP
rs199561731 30 dbSNP
rs773338588 31 dbSNP
rs762832704 32 dbSNP
rs1452489966 35 dbSNP
rs766313562 42 dbSNP
rs1407192886 43 dbSNP
rs752944618 44 dbSNP
rs1417497338 45 dbSNP
rs760974009 46 dbSNP
rs764038088 47 dbSNP
rs781486720 48 dbSNP
rs180815962 49 dbSNP
rs753955097 51 dbSNP
rs1190346962 55 dbSNP
rs752581571 57 dbSNP
rs1486825974 61 dbSNP
rs1252347823 68 dbSNP
rs1040727032 72 dbSNP
rs1182878216 82 dbSNP
rs918854345 91 dbSNP
rs1322951642 94 dbSNP
rs951609359 106 dbSNP
rs775851864 110 dbSNP
rs992308609 120 dbSNP
rs922302592 126 dbSNP
rs1300254352 132 dbSNP
rs114389393 138 dbSNP
rs948196511 142 dbSNP
rs1439246480 150 dbSNP
rs1169184144 162 dbSNP
rs1169831212 179 dbSNP
rs777837916 181 dbSNP
rs1392319120 195 dbSNP
rs1428725830 197 dbSNP
rs1166262171 210 dbSNP
rs1377049045 213 dbSNP
rs745780642 215 dbSNP
rs925350080 216 dbSNP
rs1055993616 222 dbSNP
rs1203280185 223 dbSNP
rs1415235332 223 dbSNP
rs894554219 235 dbSNP
rs771926097 239 dbSNP
rs1014329913 243 dbSNP
rs3747366 246 dbSNP
rs1304644254 252 dbSNP
rs1024220224 255 dbSNP
rs891742368 260 dbSNP
rs1297663468 269 dbSNP
rs1443081926 274 dbSNP
rs777261601 275 dbSNP
rs1050950864 279 dbSNP
rs1311244208 293 dbSNP
rs1434355896 298 dbSNP
rs185216447 305 dbSNP
rs962025359 309 dbSNP
rs1432776202 313 dbSNP
rs189785932 314 dbSNP
rs1006688398 316 dbSNP
rs1272035357 333 dbSNP
rs1472611409 337 dbSNP
rs1026000594 338 dbSNP
rs751139259 341 dbSNP
rs1227961205 342 dbSNP
rs754710871 348 dbSNP
rs1212749371 349 dbSNP
rs1315628489 359 dbSNP
rs1306960249 360 dbSNP
rs146136623 365 dbSNP
rs1201434870 367 dbSNP
rs1255867961 368 dbSNP
rs752554460 373 dbSNP
rs1025244686 378 dbSNP
rs1303190233 379 dbSNP
rs369163002 385 dbSNP
rs372513526 385 dbSNP
rs3833411 385 dbSNP
rs397896826 385 dbSNP
rs749309105 385 dbSNP
rs756049170 385 dbSNP
rs878939329 385 dbSNP
rs1242202836 387 dbSNP
rs1256476749 388 dbSNP
rs1448279386 390 dbSNP
rs1166164577 391 dbSNP
rs963787231 392 dbSNP
rs1271340717 393 dbSNP
rs757264922 394 dbSNP
rs1359534355 396 dbSNP
rs1380768763 396 dbSNP
rs951658492 396 dbSNP
rs1288076500 397 dbSNP
rs1457699522 398 dbSNP
rs992360702 400 dbSNP
rs1460498961 423 dbSNP
rs1171827835 426 dbSNP
rs1166406809 427 dbSNP
rs1426378205 428 dbSNP
rs1025177530 429 dbSNP
rs1402398089 431 dbSNP
rs922230598 435 dbSNP
rs1251726285 446 dbSNP
rs1213656888 452 dbSNP
rs1357086371 469 dbSNP
rs1318822716 472 dbSNP
rs1225430702 482 dbSNP
rs377748950 483 dbSNP
rs980929196 497 dbSNP
rs977680886 498 dbSNP
rs1435602784 499 dbSNP
rs926182641 517 dbSNP
rs758520323 528 dbSNP
rs1434553191 533 dbSNP
rs779093005 539 dbSNP
rs1295464287 540 dbSNP
rs761562513 548 dbSNP
rs1294847594 555 dbSNP
rs1373516113 558 dbSNP
rs769387511 560 dbSNP
rs1056363687 562 dbSNP
rs925372201 574 dbSNP
rs746038305 577 dbSNP
rs1393683782 581 dbSNP
rs1193498970 586 dbSNP
rs1452695862 588 dbSNP
rs772291406 592 dbSNP
rs772617961 595 dbSNP
rs780325899 608 dbSNP
rs1480417231 609 dbSNP
rs988169909 628 dbSNP
rs1230923827 631 dbSNP
rs1343976004 632 dbSNP
rs1300995868 634 dbSNP
rs913896432 636 dbSNP
rs1232439223 643 dbSNP
rs1255793160 656 dbSNP
rs1331670115 656 dbSNP
rs945987086 656 dbSNP
rs1389223039 659 dbSNP
rs1051455374 665 dbSNP
rs747366442 666 dbSNP
rs891013801 670 dbSNP
rs942542762 671 dbSNP
rs1373954708 672 dbSNP
rs183130493 683 dbSNP
rs1478635557 698 dbSNP
rs898275345 707 dbSNP
rs995202905 723 dbSNP
rs1464829499 725 dbSNP
rs776980736 726 dbSNP
rs1252651934 727 dbSNP
rs187759095 738 dbSNP
rs762421696 739 dbSNP
rs1199715836 741 dbSNP
rs374411559 743 dbSNP
rs1276503116 751 dbSNP
rs888354072 763 dbSNP
rs1454471820 773 dbSNP
rs1236821462 777 dbSNP
rs1005508167 778 dbSNP
rs1025655490 781 dbSNP
rs1288436929 790 dbSNP
rs1411271069 793 dbSNP
rs1353239400 794 dbSNP
rs1333897691 795 dbSNP
rs1018082311 796 dbSNP
rs569636109 818 dbSNP
rs1197667186 825 dbSNP
rs1375734686 827 dbSNP
rs770305051 828 dbSNP
rs774022752 833 dbSNP
rs766833498 834 dbSNP
rs976471420 837 dbSNP
rs140169598 839 dbSNP
rs142284079 842 dbSNP
rs1318654365 846 dbSNP
rs988222114 859 dbSNP
rs752468587 865 dbSNP
rs1280492016 870 dbSNP
rs1203242472 871 dbSNP
rs759954860 876 dbSNP
rs987463230 877 dbSNP
rs1332177185 879 dbSNP
rs1283194289 889 dbSNP
rs925678700 906 dbSNP
rs1387579779 909 dbSNP
rs1342574570 912 dbSNP
rs1316683644 915 dbSNP
rs1434998133 919 dbSNP
rs912490121 923 dbSNP
rs760377350 933 dbSNP
rs1459908324 955 dbSNP
rs942615948 962 dbSNP
rs868775742 978 dbSNP
rs1413194339 979 dbSNP
rs1163993854 983 dbSNP
rs936210324 999 dbSNP
rs150909555 1000 dbSNP
rs752852317 1004 dbSNP
rs1464368117 1022 dbSNP
rs916049914 1024 dbSNP
rs4828534 1025 dbSNP
rs950237241 1028 dbSNP
rs1288539562 1029 dbSNP
rs1228468620 1034 dbSNP
rs1358108054 1035 dbSNP
rs1268768283 1040 dbSNP
rs1045899021 1042 dbSNP
rs931102092 1051 dbSNP
rs1366420466 1052 dbSNP
rs897891731 1055 dbSNP
rs1439359868 1063 dbSNP
rs757237831 1068 dbSNP
rs1046798850 1073 dbSNP
rs1349305707 1084 dbSNP
rs1324361859 1086 dbSNP
rs1329125051 1088 dbSNP
rs778798140 1094 dbSNP
rs1049529616 1096 dbSNP
rs886824962 1097 dbSNP
rs777861726 1099 dbSNP
rs753916196 1100 dbSNP
rs750502698 1101 dbSNP
rs1264911871 1103 dbSNP
rs758535331 1104 dbSNP
rs1046040983 1106 dbSNP
rs1452946690 1106 dbSNP
rs905465099 1113 dbSNP
rs1204036582 1116 dbSNP
rs1002453572 1117 dbSNP
rs1300274704 1119 dbSNP
rs771271455 1120 dbSNP
rs1182680622 1121 dbSNP
rs1005848911 1124 dbSNP
rs1275487812 1128 dbSNP
rs1438749926 1134 dbSNP
rs1352868431 1137 dbSNP
rs1410898449 1138 dbSNP
rs1471580093 1144 dbSNP
rs1018218764 1147 dbSNP
rs899647304 1158 dbSNP
rs1166934476 1164 dbSNP
rs149879923 1167 dbSNP
rs1170326820 1175 dbSNP
rs1458535436 1177 dbSNP
rs1293000707 1188 dbSNP
rs191657536 1196 dbSNP
rs1424426191 1201 dbSNP
rs779923939 1211 dbSNP
rs1478697165 1219 dbSNP
rs1009704843 1220 dbSNP
rs1393332688 1220 dbSNP
rs768870030 1221 dbSNP
rs1309053053 1225 dbSNP
rs781641741 1227 dbSNP
rs1350202559 1231 dbSNP
rs1208528927 1234 dbSNP
rs967527116 1235 dbSNP
rs977199587 1235 dbSNP
rs1221452656 1238 dbSNP
rs1295583638 1261 dbSNP
rs954755963 1262 dbSNP
rs781590257 1265 dbSNP
rs1352621856 1273 dbSNP
rs1309590943 1279 dbSNP
rs770609648 1283 dbSNP
rs746978919 1296 dbSNP
rs1176631061 1297 dbSNP
rs748557096 1301 dbSNP
rs1481427313 1310 dbSNP
rs1180903960 1312 dbSNP
rs1472703075 1323 dbSNP
rs183591654 1326 dbSNP
rs1179784383 1346 dbSNP
rs964338903 1348 dbSNP
rs1483099018 1351 dbSNP
rs975352426 1354 dbSNP
rs957072474 1356 dbSNP
rs991677279 1358 dbSNP
rs1205363057 1367 dbSNP
rs1267569634 1371 dbSNP
rs1229140061 1379 dbSNP
rs773933329 1380 dbSNP
rs916144971 1383 dbSNP
rs759113953 1385 dbSNP
rs1378088209 1391 dbSNP
rs971650127 1397 dbSNP
rs754753565 1398 dbSNP
rs1386426038 1400 dbSNP
rs781162660 1402 dbSNP
rs1256848967 1405 dbSNP
rs555624784 1414 dbSNP
rs1457271355 1418 dbSNP
rs931154217 1419 dbSNP
rs929343818 1421 dbSNP
rs747752103 1424 dbSNP
rs908317137 1436 dbSNP
rs1257295210 1437 dbSNP
rs1184020110 1439 dbSNP
rs949144273 1440 dbSNP
rs1049154389 1442 dbSNP
rs1247907926 1442 dbSNP
rs909178798 1443 dbSNP
rs776530817 1444 dbSNP
rs1244333118 1463 dbSNP
rs771769474 1466 dbSNP
rs1313138212 1468 dbSNP
rs1431887076 1470 dbSNP
rs775263408 1473 dbSNP
rs760417348 1476 dbSNP
rs1169400492 1478 dbSNP
rs1319746401 1497 dbSNP
rs763759599 1500 dbSNP
rs899740585 1502 dbSNP
rs1370346506 1504 dbSNP
rs1291352062 1508 dbSNP
rs930472205 1510 dbSNP
rs1368733379 1511 dbSNP
rs376914729 1514 dbSNP
rs1046521969 1515 dbSNP
rs769616918 1516 dbSNP
rs1447994623 1521 dbSNP
rs1189700467 1526 dbSNP
rs904855665 1526 dbSNP
rs753677493 1533 dbSNP
rs1265347634 1540 dbSNP
rs1209372142 1545 dbSNP
rs1488913816 1548 dbSNP
rs903023222 1548 dbSNP
rs1380594044 1552 dbSNP
rs998980524 1552 dbSNP
rs144926408 1556 dbSNP
rs1296600754 1557 dbSNP
rs765150181 1560 dbSNP
rs1309979421 1561 dbSNP
rs772745378 1567 dbSNP
rs1308685660 1568 dbSNP
rs1298530500 1574 dbSNP
rs1385769777 1577 dbSNP
rs1390856893 1577 dbSNP
rs1228682976 1585 dbSNP
rs41305163 1591 dbSNP
rs771452137 1595 dbSNP
rs1169693340 1603 dbSNP
rs954988636 1603 dbSNP
rs1339618323 1604 dbSNP
rs758449308 1604 dbSNP
rs1198818311 1605 dbSNP
rs5969749 1605 dbSNP
rs760044742 1609 dbSNP
rs964742541 1629 dbSNP
rs1256336847 1640 dbSNP
rs973774740 1658 dbSNP
rs1179998207 1659 dbSNP
rs751738002 1663 dbSNP
rs1022620923 1665 dbSNP
rs1205668183 1666 dbSNP
rs971619311 1673 dbSNP
rs1254129773 1674 dbSNP
rs1451336169 1677 dbSNP
rs1232460884 1693 dbSNP
rs919856881 1699 dbSNP
rs981663666 1699 dbSNP
rs5969750 1702 dbSNP
rs1349551731 1704 dbSNP
rs577990942 1705 dbSNP
rs982602120 1711 dbSNP
rs1428044331 1717 dbSNP
rs950927665 1723 dbSNP
rs1400547505 1725 dbSNP
rs1172443231 1732 dbSNP
rs781355620 1744 dbSNP
rs1379436417 1746 dbSNP
rs1157104229 1748 dbSNP
rs1472374250 1760 dbSNP
rs1184649657 1766 dbSNP
rs1439281874 1767 dbSNP
rs909282707 1773 dbSNP
rs943465200 1773 dbSNP
rs908368793 1774 dbSNP
rs1039048596 1775 dbSNP
rs1327904113 1777 dbSNP
rs1301531800 1779 dbSNP
rs949198714 1780 dbSNP
rs748550336 1782 dbSNP
rs1443937114 1784 dbSNP
rs775858079 1785 dbSNP
rs1339003401 1787 dbSNP
rs933860635 1792 dbSNP
rs937705744 1803 dbSNP
rs760866271 1809 dbSNP
rs756503029 1812 dbSNP
rs894087734 1822 dbSNP
rs1362633647 1824 dbSNP
rs1235987353 1825 dbSNP
rs1412820865 1825 dbSNP
rs1051032086 1826 dbSNP
rs1279096342 1827 dbSNP
rs1471972237 1835 dbSNP
rs1366484549 1841 dbSNP
rs945599496 1850 dbSNP
rs1186639196 1857 dbSNP
rs778415045 1865 dbSNP
rs1244855917 1868 dbSNP
rs1206769851 1870 dbSNP
rs545055619 1876 dbSNP
rs890625334 1883 dbSNP
rs1009439659 1885 dbSNP
rs1225106972 1886 dbSNP
rs1017694371 1893 dbSNP
rs1353887510 1898 dbSNP
rs1283947065 1905 dbSNP
rs1465284055 1906 dbSNP
rs1319070686 1907 dbSNP
rs377105965 1907 dbSNP
rs994816501 1918 dbSNP
rs1435020930 1919 dbSNP
rs1027592669 1920 dbSNP
rs1389465090 1924 dbSNP
rs1320434896 1931 dbSNP
rs1403792660 1935 dbSNP
rs749863932 1936 dbSNP
rs892879695 1939 dbSNP
rs952658044 1940 dbSNP
rs982662461 1941 dbSNP
rs1186519195 1942 dbSNP
rs1193073808 1952 dbSNP
rs1426313261 1961 dbSNP
rs764265436 1967 dbSNP
rs1015426493 1968 dbSNP
rs1012659220 1971 dbSNP
rs188245230 1974 dbSNP
rs1210085202 1986 dbSNP
rs971046187 1986 dbSNP
rs1361965685 2011 dbSNP
rs1003051446 2016 dbSNP
rs1228297545 2017 dbSNP
rs775174386 2018 dbSNP
rs1438189508 2022 dbSNP
rs1271971950 2023 dbSNP
rs1434351984 2024 dbSNP
rs1330625654 2026 dbSNP
rs1324384506 2027 dbSNP
rs1026587464 2029 dbSNP
rs1275008661 2038 dbSNP
rs370208276 2038 dbSNP
rs1166542512 2040 dbSNP
rs774571874 2043 dbSNP
rs1420184617 2044 dbSNP
rs1366464563 2047 dbSNP
rs951060322 2055 dbSNP
rs192758640 2056 dbSNP
rs1016881162 2061 dbSNP
rs1490755626 2062 dbSNP
rs964748853 2066 dbSNP
rs1204945439 2068 dbSNP
rs923237311 2069 dbSNP
rs974830197 2069 dbSNP
rs753948802 2079 dbSNP
rs937742215 2080 dbSNP
rs1366920661 2084 dbSNP
rs1275580843 2086 dbSNP
rs1406977106 2088 dbSNP
rs989175994 2089 dbSNP
rs768356708 2093 dbSNP
rs184404547 2094 dbSNP
rs1305916387 2103 dbSNP
rs867813986 2104 dbSNP
rs761651823 2112 dbSNP
rs186658379 2115 dbSNP
rs1227671871 2120 dbSNP
rs924538005 2124 dbSNP
rs773102655 2141 dbSNP
rs934606905 2141 dbSNP
rs1176586566 2145 dbSNP
rs945648524 2146 dbSNP
rs1481196839 2149 dbSNP
rs41309665 2151 dbSNP
rs191443310 2158 dbSNP
rs751674949 2162 dbSNP
rs1039588068 2166 dbSNP
rs1208638342 2170 dbSNP
rs1312176566 2180 dbSNP
rs765363398 2198 dbSNP
rs755091343 2205 dbSNP
rs751501829 2206 dbSNP
rs1287908739 2211 dbSNP
rs5969751 2213 dbSNP
rs368680174 2222 dbSNP
rs1414594914 2225 dbSNP
rs1358548919 2227 dbSNP
rs1337347669 2228 dbSNP
rs752920788 2230 dbSNP
rs184759991 2233 dbSNP
rs1409150494 2235 dbSNP
rs1473216853 2235 dbSNP
rs1004806796 2236 dbSNP
rs781111018 2239 dbSNP
rs1026430938 2243 dbSNP
rs1406667401 2248 dbSNP
rs1323635047 2251 dbSNP
rs971028476 2255 dbSNP
rs778326944 2266 dbSNP
rs1244245956 2269 dbSNP
rs747993677 2270 dbSNP
rs1463553263 2278 dbSNP
rs749775814 2279 dbSNP
rs1240021531 2281 dbSNP
rs1319005805 2282 dbSNP
rs1006885139 2289 dbSNP
rs1226362106 2294 dbSNP
rs757864603 2295 dbSNP
rs779636320 2298 dbSNP
rs1350818720 2301 dbSNP
rs1454518911 2304 dbSNP
rs1385805370 2312 dbSNP
rs1319374628 2313 dbSNP
rs1227713138 2314 dbSNP
rs1346636012 2316 dbSNP
rs1016405211 2320 dbSNP
rs746522327 2323 dbSNP
rs376991464 2330 dbSNP
rs964886185 2334 dbSNP
rs768105422 2336 dbSNP
rs189623324 2339 dbSNP
rs372136098 2340 dbSNP
rs1448274082 2342 dbSNP
rs1030401444 2352 dbSNP
rs1321380726 2354 dbSNP
rs1486909269 2360 dbSNP
rs1263855308 2366 dbSNP
rs1221131964 2368 dbSNP
rs914953426 2369 dbSNP
rs1254434973 2371 dbSNP
rs954803708 2372 dbSNP
rs747794516 2377 dbSNP
rs1292317630 2380 dbSNP
rs1181905427 2384 dbSNP
rs945030294 2387 dbSNP
rs977721602 2393 dbSNP
rs912163007 2402 dbSNP
rs944934499 2411 dbSNP
rs1474048938 2420 dbSNP
rs777344549 2427 dbSNP
rs1294189772 2430 dbSNP
rs1382255568 2446 dbSNP
rs748979551 2446 dbSNP
rs770284482 2447 dbSNP
rs1363477678 2450 dbSNP
rs1163380261 2469 dbSNP
rs1457097746 2471 dbSNP
rs923977475 2492 dbSNP
rs1039232014 2494 dbSNP
rs1428349567 2508 dbSNP
rs922085618 2513 dbSNP
rs930774115 2527 dbSNP
rs1194550071 2531 dbSNP
rs1430324055 2532 dbSNP
rs1265369450 2533 dbSNP
rs1190827440 2534 dbSNP
rs1490592683 2540 dbSNP
rs1403271108 2545 dbSNP
rs1224494199 2549 dbSNP
rs1339837399 2549 dbSNP
rs1250641198 2557 dbSNP
rs1228078549 2560 dbSNP
rs773945019 2565 dbSNP
rs769537534 2567 dbSNP
rs1403937089 2569 dbSNP
rs1345806202 2592 dbSNP
rs1370779392 2597 dbSNP
rs1304616366 2608 dbSNP
rs1408337579 2611 dbSNP
rs1409044001 2613 dbSNP
rs914378593 2616 dbSNP
rs886497566 2625 dbSNP
rs57547802 2627 dbSNP
rs1342235042 2628 dbSNP
rs948575368 2630 dbSNP
rs1044234338 2631 dbSNP
rs1180316252 2632 dbSNP
rs1480866165 2632 dbSNP
rs762817842 2632 dbSNP
rs181875876 2633 dbSNP
rs1378451384 2634 dbSNP
rs1249561065 2637 dbSNP
rs774223217 2640 dbSNP
rs1481609196 2643 dbSNP
rs1244063104 2648 dbSNP
rs1046129445 2650 dbSNP
rs1323653316 2651 dbSNP
rs938466527 2662 dbSNP
rs1226196355 2670 dbSNP
rs1335545889 2671 dbSNP
rs759649052 2674 dbSNP
rs1277123217 2688 dbSNP
rs1047391676 2700 dbSNP
rs1393627977 2712 dbSNP
rs1003864005 2715 dbSNP
rs886109673 2724 dbSNP
rs1336681336 2725 dbSNP
rs1470314634 2725 dbSNP
rs1343123302 2728 dbSNP
rs1204956551 2729 dbSNP
rs1157127691 2736 dbSNP
rs1472424182 2739 dbSNP
rs1033559386 2743 dbSNP
rs1362994840 2748 dbSNP
rs1182317473 2752 dbSNP
rs1439458613 2753 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 55787.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuuaauccaucaccGUCACCUu 5'
                        ||||||| 
Target 5' --------------CAGUGGAg 3'
 		1 - 8
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000380122.5 | 3UTR | CAGUGGAGGAAAAUAAAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6509-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055374 PDCD4 programmed cell death 4 2 4
MIRT378341 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT444668 CDKL2 cyclin dependent kinase like 2 2 2
MIRT446953 CD248 CD248 molecule 2 2
MIRT460332 CAMK4 calcium/calmodulin dependent protein kinase IV 2 6
MIRT464078 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464586 UBN2 ubinuclein 2 2 2
MIRT468482 SESN3 sestrin 3 2 2
MIRT468962 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT475455 HSPA8 heat shock protein family A (Hsp70) member 8 2 2
MIRT482403 ADRB1 adrenoceptor beta 1 2 10
MIRT486992 ZFAND2B zinc finger AN1-type containing 2B 2 2
MIRT489397 TUBB2A tubulin beta 2A class IIa 2 2
MIRT526319 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526560 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526732 ZNF138 zinc finger protein 138 2 8
MIRT531581 STXBP5L syntaxin binding protein 5 like 2 2
MIRT532011 NOX5 NADPH oxidase 5 2 2
MIRT533407 TXLNG taxilin gamma 2 2
MIRT533436 TRPC5 transient receptor potential cation channel subfamily C member 5 2 2
MIRT533866 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT539254 ANKRD50 ankyrin repeat domain 50 2 2
MIRT541451 C15orf48 chromosome 15 open reading frame 48 2 2
MIRT566794 MIER3 MIER family member 3 2 2
MIRT569294 SURF6 surfeit 6 2 2
MIRT571336 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT572802 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT572813 MYO1C myosin IC 2 2
MIRT574219 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT607259 GRAMD1B GRAM domain containing 1B 2 4
MIRT609307 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT615459 REPS1 RALBP1 associated Eps domain containing 1 2 2
MIRT616861 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT619415 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT619652 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT625325 TNFRSF13B TNF receptor superfamily member 13B 2 2
MIRT638980 ARFIP2 ADP ribosylation factor interacting protein 2 2 2
MIRT639458 ZNF429 zinc finger protein 429 2 2
MIRT640550 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT641473 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT642720 ATXN3 ataxin 3 2 2
MIRT643048 SMN1 survival of motor neuron 1, telomeric 2 2
MIRT644921 SMN2 survival of motor neuron 2, centromeric 2 2
MIRT645875 ZNF275 zinc finger protein 275 2 2
MIRT649824 LIPG lipase G, endothelial type 2 2
MIRT649851 GYS2 glycogen synthase 2 2 2
MIRT649972 TRAFD1 TRAF-type zinc finger domain containing 1 2 2
MIRT650675 ZNF259 ZPR1 zinc finger 1 1
MIRT651319 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT652876 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT652881 SYVN1 synoviolin 1 2 2
MIRT654144 RPAP2 RNA polymerase II associated protein 2 2 2
MIRT657080 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657181 INO80C INO80 complex subunit C 2 2
MIRT657830 GJD3 gap junction protein delta 3 2 2
MIRT657897 GDF7 growth differentiation factor 7 2 2
MIRT659631 CDKN2AIP CDKN2A interacting protein 2 2
MIRT663115 SPTA1 spectrin alpha, erythrocytic 1 2 2
MIRT664739 METTL16 methyltransferase like 16 2 2
MIRT667551 LRAT lecithin retinol acyltransferase 2 2
MIRT668552 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT682893 XIAP X-linked inhibitor of apoptosis 2 2
MIRT683092 PRRG4 proline rich and Gla domain 4 2 2
MIRT683102 TIMM10B translocase of inner mitochondrial membrane 10B 2 2
MIRT697648 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT709158 ZNF419 zinc finger protein 419 2 2
MIRT713220 RCAN2 regulator of calcineurin 2 2 2
MIRT713277 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT715008 CYP1B1 cytochrome P450 family 1 subfamily B member 1 2 2
MIRT715051 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT715696 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT717250 TMEM246 transmembrane protein 246 2 2
MIRT717322 PGK1 phosphoglycerate kinase 1 2 2
MIRT717587 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT718122 CHST4 carbohydrate sulfotransferase 4 2 2
MIRT718418 CALN1 calneuron 1 2 2
MIRT718750 ZNF490 zinc finger protein 490 2 2
MIRT720048 PPP1R3F protein phosphatase 1 regulatory subunit 3F 2 2
MIRT721497 THRB thyroid hormone receptor beta 2 2
MIRT722531 EPRS glutamyl-prolyl-tRNA synthetase 2 2
MIRT723279 KRTAP21-2 keratin associated protein 21-2 2 2
MIRT724813 MSX2 msh homeobox 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6509-3p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6509-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6509-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6509-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6509-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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