miRTarBase - #MIRT533419


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pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TWF1   
Synonyms A6, PTK9
Description twinfilin actin binding protein 1
Transcript NM_002822   
Expression
Putative miRNA Targets on TWF1
3'UTR of TWF1
(miRNA target sites are highlighted)		 
>TWF1|NM_002822|3'UTR
   1 AGTCATCACATTAAACATTGTAATACTAGTTTTTTAAAAGTCCAGCTTTTAGTACAGGAGAACTGAAATCATTCCATGTT
  81 GATATAAAGTAGGGAAAAAAATTGTACTTTTTGGAAAATAGCACTTTTCACTTCTGTGTGTTTTTAAAATTAATGTTATA
 161 GAAGACTCATGATTTCTATTTTTGAGTTAAAGCTAGAAAAGGGTTCAACATAATGTTTAATTTTGTCACACTGTTTTCAT
 241 AGCGTTGATTCCACACTTCAAATACTTCTTAAAATTTTATACAGTTGGGCCAGTTCTAGAAAGTCTGATGTCTCAAAGGG
 321 TAAACTTACTACTTTCTTGTGGGACAGAAAGACCTTAAAATATTCATATTACTTAATGAATATGTTAAGGACCAGGCTAG
 401 AGTATTTTCTAAGCTGGAAACTTAGTGTGCCTTGGAAAAGGCCGCAAGTTGCTTACTCCGAGTAGCTGTGCTAGCTCTGT
 481 CAGACTGTAGGATCATGTCTGCAACTTTTAGAAATAGTGCTTTATATTGCAGCAGTCTTTTATATTTGACTTTTTTTTAA
 561 TAGCATTAAAATTGCAGATCAGCTCACTCTGAAACTTTAAGGGTACCAGATATTTTCTATACTGCAGGATTTCTGATGAC
 641 ATTGAAAGACTTTAAACAGCCTTAGTAAATTATCTTTCTAATGCTCTGTGAGGCCAAACATTTATGTTCAGATTGAAATT
 721 TAAATTAATATCATTCAAAAGGAAACAAAAAATGTTGAGTTTTAAAAATCAGGATTGACTTTTTTCTCCAAAACCATACA
 801 TTTATGGGCAAATTGTGTTCTTTATCACTTCCGAGCAAATACTCAGATTTAAAATTACTTTAAAGTCCTGGTACTTAACA
 881 GGCTAACGTAGATAAACACCTTAATAATCTCAGTTAATACTGTATTTCAAAACACATTTAACTGTTTTCTAATGCTTTGC
 961 ATTATCAGTTACAACCTAGAGAGATTTTGAGCCTCATATTTCTTTGATACTTGAAATAGAGGGAGCTAGAACACTTAATG
1041 TTTAATCTGTTAAACCTGCTGCAAGAGCCATAACTTTGAGGCATTTTCTAAATGAACTGTGGGGATCCAGGATTTGTAAT
1121 TTCTTGATCTAAACTTTATGCTGCATAAATCACTTATCGGAAATGCACATTTCATAGTGTGAAGCACTCATTTCTAAACC
1201 TTATTATCTAAGGTAATATATGCACCTTTCAGAAATTTGTGTTCGAGTAAGTAAAGCATATTAGAATAATTGTGGGTTGA
1281 CAGATTTTTAAAATAGAATTTAGAGTATTTGGGGTTTTGTTTGTTTACAAATAATCAGACTATAATATTTAAACATGCAA
1361 AATAACTGACAATAATGTTGCACTTGTTTACTAAAGATATAAGTTGTTCCATGGGTGTACACGTAGACAGACACACATAC
1441 ACCCAAATTATTGCATTAAGAATCCTGGAGCAGACCATAGCTGAAGCTGTTATTTTCAGTCAGGAAGACTACCTGTCATG
1521 AAGGTATAAAATAATTTAGAAGTGAATGTTTTTCTGTACCATCTATGTGCAATTATACTCTAAATTCCACTACACTACAT
1601 TAAAGTAAATGGACATTCCAGAATATAGATGTGATTATAGTCTTAAACTAATTATTATTAAACCAATGATTGCTGAAAAT
1681 CAGTGATGCATTTGTTATAGAGTATAACTCATCGTTTACAGTATGTTTTAGTTGGCAGTATCATACCTAGATGGTGAATA
1761 ACATATTCCCAGTAAATTTATATAGCAGTGAAGAATTACATGCCTTCTGGTGGACATTTTATAAGTGCATTTTATATCAC
1841 AATAAAAATTTTTTCTCTTTAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgguucccuuacCGUCCCUUUa 5'
                      |:||||||| 
Target 5' tgttgatataaaGTAGGGAAAa 3'
 77 - 98 146.00 -11.20
2 
miRNA  3' cgguucCCUUACCGUCCCUUua 5'
                | ||| | |||||:  
Target 5' atacttGAAATAG-AGGGAGct 3'
 1007 - 1027 115.00 -9.50
3 
miRNA  3' cggUUC-CCUUACCG----UCCCUUUa 5'
             |||   :||| |    |||| || 
Target 5' agaAAGTCTGATGTCTCAAAGGGTAAa 3'
 298 - 324 113.00 -7.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30190011 4 COSMIC
COSN30106752 7 COSMIC
COSN30458841 9 COSMIC
COSN31519715 29 COSMIC
COSN13395521 60 COSMIC
COSN30157197 74 COSMIC
COSN30138502 91 COSMIC
COSN31649450 114 COSMIC
COSN30102996 125 COSMIC
COSN31539475 274 COSMIC
COSN17075960 364 COSMIC
COSN16908104 397 COSMIC
COSN21733823 709 COSMIC
COSN21176674 764 COSMIC
COSN31533958 984 COSMIC
COSN31531525 1184 COSMIC
COSN24304391 1278 COSMIC
COSN20626814 1323 COSMIC
COSN29338484 1331 COSMIC
COSN24853546 1423 COSMIC
COSN31527660 1530 COSMIC
COSN30174441 1700 COSMIC
COSN31486368 1713 COSMIC
COSN31513624 1729 COSMIC
COSN22460466 1785 COSMIC
COSN24304390 1796 COSMIC
COSN1573890 1836 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773643762 4 dbSNP
rs921443984 7 dbSNP
rs768039861 9 dbSNP
rs761332163 16 dbSNP
rs373297018 17 dbSNP
rs768298154 18 dbSNP
rs1392156692 19 dbSNP
rs749004245 21 dbSNP
rs1453747641 25 dbSNP
rs1253486655 28 dbSNP
rs1194963696 29 dbSNP
rs1463214370 40 dbSNP
rs1266925514 42 dbSNP
rs369394985 45 dbSNP
rs1352360642 50 dbSNP
rs1306807968 76 dbSNP
rs1334345879 77 dbSNP
rs765571809 78 dbSNP
rs1225672480 79 dbSNP
rs1264331454 84 dbSNP
rs1284254541 89 dbSNP
rs569070697 95 dbSNP
rs745965976 99 dbSNP
rs944295063 102 dbSNP
rs1252535789 105 dbSNP
rs912850201 106 dbSNP
rs1176266124 111 dbSNP
rs988206856 112 dbSNP
rs1339186222 118 dbSNP
rs1434697951 127 dbSNP
rs1199813886 151 dbSNP
rs1309793072 159 dbSNP
rs1428549139 161 dbSNP
rs1468134917 168 dbSNP
rs935042095 172 dbSNP
rs192639904 178 dbSNP
rs979197043 184 dbSNP
rs1297835891 186 dbSNP
rs1023481675 196 dbSNP
rs992038931 201 dbSNP
rs111381081 202 dbSNP
rs184208840 210 dbSNP
rs1426756638 227 dbSNP
rs1391783164 239 dbSNP
rs535312216 243 dbSNP
rs1026998124 244 dbSNP
rs574183025 252 dbSNP
rs546580839 254 dbSNP
rs1802561 259 dbSNP
rs1420057414 261 dbSNP
rs866306708 261 dbSNP
rs1250792861 262 dbSNP
rs1169780653 281 dbSNP
rs1371595472 290 dbSNP
rs115917962 299 dbSNP
rs1304195895 302 dbSNP
rs944243097 306 dbSNP
rs891361041 307 dbSNP
rs1291161190 314 dbSNP
rs1490724788 318 dbSNP
rs1363206056 321 dbSNP
rs567330513 329 dbSNP
rs1292776265 336 dbSNP
rs1361211191 340 dbSNP
rs1246240780 341 dbSNP
rs1290846184 345 dbSNP
rs1489799449 351 dbSNP
rs934970361 371 dbSNP
rs191959992 372 dbSNP
rs1353665246 375 dbSNP
rs1186055053 383 dbSNP
rs531002149 389 dbSNP
rs924986156 400 dbSNP
rs749390153 412 dbSNP
rs1384785024 415 dbSNP
rs1403973485 416 dbSNP
rs866833538 419 dbSNP
rs61933173 420 dbSNP
rs1161680766 421 dbSNP
rs1346343264 425 dbSNP
rs1430612273 428 dbSNP
rs1237153154 429 dbSNP
rs866490724 433 dbSNP
rs563952739 443 dbSNP
rs545274303 444 dbSNP
rs1313940148 455 dbSNP
rs1331855444 459 dbSNP
rs916373710 460 dbSNP
rs1284667354 461 dbSNP
rs1316327870 462 dbSNP
rs1213557328 464 dbSNP
rs1244829588 484 dbSNP
rs991979455 486 dbSNP
rs187670930 495 dbSNP
rs1242794440 499 dbSNP
rs1471914081 505 dbSNP
rs1179365582 506 dbSNP
rs1400705760 508 dbSNP
rs1157595352 509 dbSNP
rs1408864793 510 dbSNP
rs11834357 511 dbSNP
rs1469898329 514 dbSNP
rs1335457295 523 dbSNP
rs1160081732 525 dbSNP
rs1380187355 531 dbSNP
rs1443908093 535 dbSNP
rs1015232341 537 dbSNP
rs1372357267 538 dbSNP
rs777830001 540 dbSNP
rs754917999 542 dbSNP
rs1264954668 545 dbSNP
rs150162165 555 dbSNP
rs1204426948 559 dbSNP
rs951422472 561 dbSNP
rs540995868 562 dbSNP
rs1440962838 564 dbSNP
rs995505054 565 dbSNP
rs1233599264 572 dbSNP
rs1478889403 585 dbSNP
rs1246870827 591 dbSNP
rs746894867 596 dbSNP
rs899918180 598 dbSNP
rs1432135577 604 dbSNP
rs1018344342 607 dbSNP
rs1175161903 610 dbSNP
rs1399429319 626 dbSNP
rs140904391 630 dbSNP
rs183330154 635 dbSNP
rs1329149229 642 dbSNP
rs1353514277 647 dbSNP
rs1208865333 648 dbSNP
rs1329018704 651 dbSNP
rs1407802019 652 dbSNP
rs1284924314 659 dbSNP
rs1346124804 664 dbSNP
rs555427981 672 dbSNP
rs1282798268 684 dbSNP
rs1342966935 699 dbSNP
rs1197571793 701 dbSNP
rs1274000165 703 dbSNP
rs1437432474 713 dbSNP
rs1203514930 714 dbSNP
rs1266812352 731 dbSNP
rs891315001 736 dbSNP
rs1053088506 738 dbSNP
rs1490675840 744 dbSNP
rs1479822888 755 dbSNP
rs1376375158 757 dbSNP
rs1225658288 772 dbSNP
rs999789978 774 dbSNP
rs867587318 779 dbSNP
rs1167953251 796 dbSNP
rs761630803 797 dbSNP
rs1274690590 804 dbSNP
rs3990369 806 dbSNP
rs116442992 810 dbSNP
rs1304788982 816 dbSNP
rs1365955856 819 dbSNP
rs758165588 827 dbSNP
rs866944834 832 dbSNP
rs1328078613 833 dbSNP
rs1321273905 837 dbSNP
rs1270824167 842 dbSNP
rs1339046795 845 dbSNP
rs1226457962 846 dbSNP
rs1294140852 851 dbSNP
rs947736210 863 dbSNP
rs916314561 870 dbSNP
rs1056242962 879 dbSNP
rs11556066 881 dbSNP
rs907708788 882 dbSNP
rs1447352096 883 dbSNP
rs192434354 887 dbSNP
rs1385408148 888 dbSNP
rs538466561 891 dbSNP
rs1416161998 892 dbSNP
rs1161199929 900 dbSNP
rs1425607126 901 dbSNP
rs1211507017 902 dbSNP
rs1387098184 903 dbSNP
rs1382698718 918 dbSNP
rs571532912 919 dbSNP
rs1364555489 921 dbSNP
rs920544153 922 dbSNP
rs1432920013 931 dbSNP
rs546938203 934 dbSNP
rs1360394820 937 dbSNP
rs1391652970 939 dbSNP
rs1244571765 945 dbSNP
rs1264021370 954 dbSNP
rs867247117 955 dbSNP
rs1353540600 960 dbSNP
rs1206232666 967 dbSNP
rs1284098466 974 dbSNP
rs534584912 978 dbSNP
rs567310677 985 dbSNP
rs1243409853 996 dbSNP
rs1018291976 998 dbSNP
rs1246663044 1000 dbSNP
rs1008326981 1006 dbSNP
rs1365320714 1011 dbSNP
rs1454062818 1022 dbSNP
rs1157943546 1025 dbSNP
rs1386305950 1033 dbSNP
rs549095021 1035 dbSNP
rs1443563743 1039 dbSNP
rs1338751358 1062 dbSNP
rs1278322703 1067 dbSNP
rs1199146645 1070 dbSNP
rs1395653564 1072 dbSNP
rs1311106696 1073 dbSNP
rs1341688736 1074 dbSNP
rs1337903831 1077 dbSNP
rs1298615024 1081 dbSNP
rs1240131377 1083 dbSNP
rs1288293584 1095 dbSNP
rs530579560 1101 dbSNP
rs1227688611 1110 dbSNP
rs1263193961 1111 dbSNP
rs1031172728 1112 dbSNP
rs1363102976 1113 dbSNP
rs563244850 1125 dbSNP
rs1450092703 1138 dbSNP
rs551916006 1153 dbSNP
rs1000142159 1154 dbSNP
rs1333209082 1156 dbSNP
rs1412573370 1158 dbSNP
rs904098587 1159 dbSNP
rs1178743725 1169 dbSNP
rs1406911927 1179 dbSNP
rs1044024200 1196 dbSNP
rs1168848834 1201 dbSNP
rs1448558359 1207 dbSNP
rs533380255 1212 dbSNP
rs1392364590 1213 dbSNP
rs1288080596 1219 dbSNP
rs1349234343 1223 dbSNP
rs1225883415 1225 dbSNP
rs559593970 1244 dbSNP
rs1011895475 1250 dbSNP
rs894826448 1253 dbSNP
rs1311119735 1259 dbSNP
rs1387777408 1264 dbSNP
rs552168065 1268 dbSNP
rs939115244 1286 dbSNP
rs1204245051 1293 dbSNP
rs907653835 1317 dbSNP
rs1490838242 1319 dbSNP
rs1200062335 1324 dbSNP
rs764238770 1327 dbSNP
rs1432693011 1329 dbSNP
rs1173991706 1343 dbSNP
rs1375040770 1346 dbSNP
rs1462667663 1351 dbSNP
rs1047547515 1356 dbSNP
rs930499777 1358 dbSNP
rs1208377250 1370 dbSNP
rs920495188 1373 dbSNP
rs1275872311 1383 dbSNP
rs1384613793 1387 dbSNP
rs1297075339 1392 dbSNP
rs1204701009 1394 dbSNP
rs1307776751 1397 dbSNP
rs1227199952 1399 dbSNP
rs573691871 1403 dbSNP
rs974651256 1406 dbSNP
rs561794574 1409 dbSNP
rs963986902 1411 dbSNP
rs543458117 1412 dbSNP
rs911232431 1415 dbSNP
rs1228989541 1422 dbSNP
rs576442302 1423 dbSNP
rs1426984838 1425 dbSNP
rs1164575620 1428 dbSNP
rs1031539579 1433 dbSNP
rs1434931538 1436 dbSNP
rs1445463676 1437 dbSNP
rs1433631654 1440 dbSNP
rs999687583 1443 dbSNP
rs557988233 1447 dbSNP
rs1022524279 1452 dbSNP
rs1246490410 1472 dbSNP
rs538798597 1477 dbSNP
rs1012510665 1479 dbSNP
rs894774125 1481 dbSNP
rs1217858651 1501 dbSNP
rs1261179276 1506 dbSNP
rs1465418736 1523 dbSNP
rs1187960948 1529 dbSNP
rs1308478462 1530 dbSNP
rs1428669199 1531 dbSNP
rs577941422 1536 dbSNP
rs1368369117 1538 dbSNP
rs775501218 1539 dbSNP
rs1166225532 1556 dbSNP
rs1446648627 1560 dbSNP
rs1034685988 1564 dbSNP
rs1003652744 1566 dbSNP
rs1405450239 1567 dbSNP
rs1413633743 1570 dbSNP
rs375367040 1590 dbSNP
rs1161927817 1593 dbSNP
rs1473896991 1600 dbSNP
rs1456276216 1603 dbSNP
rs1252956179 1605 dbSNP
rs1181972855 1634 dbSNP
rs1452897185 1637 dbSNP
rs1047957156 1649 dbSNP
rs1376718989 1651 dbSNP
rs1225211340 1655 dbSNP
rs1307658324 1661 dbSNP
rs534962974 1663 dbSNP
rs1328352275 1666 dbSNP
rs1208243726 1667 dbSNP
rs1248709566 1675 dbSNP
rs1222307849 1686 dbSNP
rs1321206924 1687 dbSNP
rs930456585 1690 dbSNP
rs1237058664 1694 dbSNP
rs1300510957 1698 dbSNP
rs1179275267 1700 dbSNP
rs1389466909 1700 dbSNP
rs1413393176 1701 dbSNP
rs1331190286 1710 dbSNP
rs899018176 1713 dbSNP
rs1409011612 1714 dbSNP
rs1430780075 1715 dbSNP
rs1414476146 1716 dbSNP
rs567569462 1720 dbSNP
rs943295401 1721 dbSNP
rs1298516199 1725 dbSNP
rs1436827932 1733 dbSNP
rs1226496666 1749 dbSNP
rs1285047182 1765 dbSNP
rs1219832748 1766 dbSNP
rs911837637 1784 dbSNP
rs986812199 1794 dbSNP
rs1440876091 1814 dbSNP
rs934015032 1817 dbSNP
rs1252971818 1821 dbSNP
rs781171026 1823 dbSNP
rs1483053596 1830 dbSNP
rs372167070 1834 dbSNP
rs978593968 1836 dbSNP
rs968174484 1842 dbSNP
rs1022473925 1844 dbSNP
rs1422684972 1847 dbSNP
rs1348792136 1848 dbSNP
rs1169060431 1850 dbSNP
rs1369728452 1860 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 5756.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgguucccuuacCGUCCCUUUa 5'
                      |:||||||| 
Target 5' -----auauaaaGUAGGGAAAa 3'
 		1 - 17
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000552521.1 | 3UTR | AUAUAAAGUAGGGAAAAAAAUUGUACUUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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