miRTarBase - #MIRT533681


—
pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TMEM86A   
Synonyms -
Description transmembrane protein 86A
Transcript NM_153347   
Expression
Putative miRNA Targets on TMEM86A
3'UTR of TMEM86A
(miRNA target sites are highlighted)		 
>TMEM86A|NM_153347|3'UTR
   1 GGTGCCAGGGTCTGGTCACCCCTCTCTCCTCCTGGGGCTGGGGCCCAGATCCTGGGGACCTGCAGGAGCTGGATCAGGAT
  81 GGCTGCAGTGCCAGCCTGGGGCAGCAGGTACTGCCTGAGGAATTTGCAAGTTCGTGTGGGGAGGCTGGAAAAGGATCTCC
 161 CTAGCAGAACTCGTGGTTCAGGACAATGCTGAGAGCTAAAAGAGCCAGCCTAATATCAGACTGGAGCCAGAAGTAGACAT
 241 CTCCCCACCTCTACCCTATCAGGACTTTCAAAACCCCCCTGGAAGGTGATGGTGCTCAGCTTCTTGACACCCCCCCACCC
 321 ACTTCCCCTACCAGGTGGAAGAGTCTGACTCCATGTGTTATGCCTAGGACCAATGGCAGTGCTGGGTTCACCCACTCCTC
 401 CCCTTTTTCATCTGCACAAAGTTGAGGGAAACGGGAGAATCTGTGCTGAGAAGACTCAGACCCAGGAGCCCCTTTCACAG
 481 GCCCCTAGTTGGGAAGACTGGATGAGAGTGGAGCCTCCGTTTCTTTTCCCTCTTCTATCCTTGTTACTTGAACAATCTCA
 561 GTCTCTAAGTGGTGGGTGGGGACATGAAGAGGTGTGGGTCCAGGTTAGGCAGGAGAGAGAACTTCTTTGGTCTCGGAGTT
 641 TGGGGTCTCAAGAATTCAAGTAGCCCCATCTCTCTCTCGGGCAAGCCCAAAGCTCAGGTCCCATACGCTACCCTTAGATC
 721 CTATCCCCAGGGCTAGGGTGAACCATGCCAAAGGAAGGGGCCAGCTTCTCTGTGTGTGTGTGTAGCCTGTCTCCTAGTCT
 801 GCCTATGTCTTTCTCTGCTATATGTTTCTGTCCTGCTGTCTGTCAAAAGTCTCACAGAGAGAGGGCCTCAGGGAGCTGCT
 881 GAGGGGTGCTGAGCCTGGCTCAGGGAGCTGGGACCCCTCCCCTCCAACACACATACTCACAGTGCTTTCCTCCTTGTCCC
 961 TCCTACACTAGGAGCAAGAGGAGGGGGCTCCAATGACACTCCGGGGTTTTAAGACCCAAGGCACATTCAATGCAAGGGGA
1041 GCAAGGATGGGACAACTCCATCTTCTGCTGCCCATGTGAAAAATAATAAAAATCAAGAGCCATTGGCTGCCCTGCTTGTG
1121 GGCCTGTGTGGCACATGCCTATCTTGGAGAGGGCATGGGGGCATGGTGCCAGAGGCTCTGGCTGTCCTCACAGCCTAGTC
1201 ACAGTCCTGGGCAGTGCATCTTGGTGCCAGGCTGGCTACCTGGCTCTGGTGACACTGTGCCGGTTGGAGTGTGTCTCACT
1281 TCCCTGGTGTGGGTGAGGATGTGGTTTAGGAGGATGGGGGATGAGTGGTATTTGCCACTGTCCAAATTTGTCCTTGATGT
1361 ACTCCCCTGTGCACAGGTGCCCAGCACCCTTGGTGACCTTTAGTTACCCAGTGTCATCTATTGCTGCCCACCTCCTCCCC
1441 TCCCCACTTGAGACCTGCTGCTTCCTTCAAAATGATCCAGATTCCCTTCAAGCATCTCCCTCATCCTGGACTCTGGGCTT
1521 AGTTGAACAGCTGGGAGCAATGGGATTAGATTGGCTGATTCATTCATTAGTTGTAAAGCCCTGGCAGAATAATACATCAC
1601 TCTGCTCCAGGAGCATTTGTAACTTAACAGACAATGCCCTAACCCAGAAGTAGAAAGGGAAGCCTTGGGTGGTGGTGGAT
1681 ATGCCATCAGTAGAGGTGTTGCTCATTTGTGGGGATGTGATTTAGGAGACTCAAGTCTCAGGGGTGGTTGGATGAGTCAG
1761 TGATTTCCAAATTAGTTTTTACAGAGATTCCTGGTAAGGGGGTAGTGAAGGAATAATGAGAGAAGGCAGGCTCAAAGACC
1841 TCCTATCCTTATTTCAAGTCCAGTAGCTTCTTAGGTTGTGTTTTTTTTTGTTTTGTTTTGTTTTGGAAGGATTCCACTGA
1921 AAAACGTAAGTTTGAAACTTAGTGAGCTGGATGATCAATCCCTTCTAGCTCTGAACCCTGGACACTAAAGAGGGAAGATC
2001 TTGATCCTTTCAAACTTCAGAACTCTGAACACAGACCTACCTAGTGTGAAGAAATGGGAGGGAGCAGGATGGAGAGCAGG
2081 ATGAAGTCAGCAGGACTTGCCCCCAAGCTCTGAGGGGAGGGGGAAAGTGCCATGTAGATGTGGAGGAGGGGAAGGGAAGA
2161 CCAGGCCCAGTCACAAGAAGGCTGGTCACTGCCTTGTGGGTGGGTTTGGACTAGGCTTTCAGGGGTCCAGGTCTGGGATT
2241 CCCTATCATGCAATCACATCCATCCCCTTGGTCCCTGCTGTATATCACCCTCAGGAACGGGAAAGGATGAGTTACGTTTA
2321 TTGCCCCATCCCTTCACTGAATGTTTACATTAACAAACACCAGAGAGCAAACTGGGCTTCCTACACTGGGCCATGCAGAG
2401 GACAGGCCAAGAAACTCCACATCATAACAGCCTCCTGATGCCTGGGCTTGGCTGGAGCTCACATGAGGTGCTTTGATTTC
2481 TTCTGCAGACTCTCGGTGATGGATGCTACAACTGACTTATCATCTTTGTCTGAAAGAGCAAAGGAAGTATTCGTTATATT
2561 AATGATGCTGGCGACCAGGGAAATTCCAAACTGCTGGACTTCCTATGCAGGAAACCAGGAGCTGGACCCTGGGACCCTTA
2641 ATCTTGGGTTGGCAGAGTGTGAAGGGGCAAGAGCTGCCATTTATCTAGCACTTAATATTTGCCAGACATTGTGCCAGGCA
2721 GTTGTGTACTGTCTCATTTAAGCCTCATAGTCCTATAAAGAAGATGAGAAAACAGGAAAAAAAAAAAAAAAAAAAAAAAA
2801 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acgGUCGGAGCGGGUCg 5'
             |||   :|||||| 
Target 5' gcaCAG--GTGCCCAGc 3'
 1371 - 1385 126.00 -18.70
2 
miRNA  3' acggucggagCGGGUCg 5'
                    |||||| 
Target 5' tggggctgggGCCCAGa 3'
 33 - 49 120.00 -14.40
3 
miRNA  3' acggucggagCGGGUCg 5'
                    |||||| 
Target 5' ggaagaccagGCCCAGt 3'
 2155 - 2171 120.00 -15.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30486379 14 COSMIC
COSN30453258 21 COSMIC
COSN30527321 26 COSMIC
COSN30532268 34 COSMIC
COSN30465515 37 COSMIC
COSN30469856 53 COSMIC
COSN31559528 64 COSMIC
COSN30493339 68 COSMIC
COSN18735846 128 COSMIC
COSN28645080 134 COSMIC
COSN30176360 193 COSMIC
COSN24995330 226 COSMIC
COSN31486755 270 COSMIC
COSN31590577 377 COSMIC
COSN30539753 402 COSMIC
COSN30539817 404 COSMIC
COSN5902595 722 COSMIC
COSN31562844 784 COSMIC
COSN31547239 981 COSMIC
COSN28681783 1003 COSMIC
COSN30541846 1152 COSMIC
COSN31778844 1153 COSMIC
COSN1522942 2285 COSMIC
COSN31580686 2299 COSMIC
COSN30138242 2300 COSMIC
COSN17078609 2317 COSMIC
COSN21353539 2340 COSMIC
COSN30177774 2353 COSMIC
COSN30137771 2357 COSMIC
COSN31557737 2364 COSMIC
COSN30119790 2373 COSMIC
COSN30134586 2412 COSMIC
COSN30135613 2439 COSMIC
COSN26563421 2452 COSMIC
COSM1210409 2481 COSMIC
COSM1188190 2495 COSMIC
COSM5144295 2515 COSMIC
COSM5991094 2516 COSMIC
COSM8822855 2523 COSMIC
COSN31520246 2582 COSMIC
COSN31491703 2635 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1461362555 6 dbSNP
rs1298693085 9 dbSNP
rs760734971 11 dbSNP
rs1394035986 14 dbSNP
rs763866696 18 dbSNP
rs553695738 23 dbSNP
rs746562942 23 dbSNP
rs1355680390 24 dbSNP
rs1234818775 28 dbSNP
rs753684002 30 dbSNP
rs1306423550 37 dbSNP
rs756874657 38 dbSNP
rs1254647191 43 dbSNP
rs1252441063 49 dbSNP
rs1206545296 52 dbSNP
rs546634501 64 dbSNP
rs966172686 69 dbSNP
rs997287818 73 dbSNP
rs923481626 79 dbSNP
rs1284261878 90 dbSNP
rs572062362 92 dbSNP
rs1348520289 93 dbSNP
rs1309728471 95 dbSNP
rs1410378637 96 dbSNP
rs1349027744 99 dbSNP
rs933485890 100 dbSNP
rs1407285886 109 dbSNP
rs1414864445 112 dbSNP
rs545580021 117 dbSNP
rs955890563 119 dbSNP
rs986983563 126 dbSNP
rs79772016 134 dbSNP
rs1414311853 135 dbSNP
rs760371773 144 dbSNP
rs576093069 147 dbSNP
rs1183463137 150 dbSNP
rs1378642983 160 dbSNP
rs1240513633 161 dbSNP
rs942419659 164 dbSNP
rs1345143639 166 dbSNP
rs1038044118 173 dbSNP
rs970060008 174 dbSNP
rs144959681 177 dbSNP
rs1326398368 181 dbSNP
rs929909762 194 dbSNP
rs1268980610 197 dbSNP
rs1047010125 217 dbSNP
rs896342577 221 dbSNP
rs938763659 225 dbSNP
rs1013434952 227 dbSNP
rs1023868565 238 dbSNP
rs905281100 240 dbSNP
rs370927356 241 dbSNP
rs767861689 246 dbSNP
rs563148693 249 dbSNP
rs755048413 264 dbSNP
rs1320085557 267 dbSNP
rs1032339251 270 dbSNP
rs755563455 270 dbSNP
rs931486548 274 dbSNP
rs564064665 275 dbSNP
rs1394506005 276 dbSNP
rs988376825 277 dbSNP
rs1174760843 278 dbSNP
rs1030525635 290 dbSNP
rs75027358 291 dbSNP
rs772552715 302 dbSNP
rs1463269288 308 dbSNP
rs986333917 309 dbSNP
rs1215952605 310 dbSNP
rs942996479 310 dbSNP
rs1311507271 311 dbSNP
rs1327267647 312 dbSNP
rs756925015 313 dbSNP
rs1402964284 314 dbSNP
rs1220898089 315 dbSNP
rs910671718 316 dbSNP
rs901546587 317 dbSNP
rs1321275428 318 dbSNP
rs1465642170 325 dbSNP
rs1357530940 332 dbSNP
rs1178806007 333 dbSNP
rs1368060381 336 dbSNP
rs1415557783 344 dbSNP
rs149050596 346 dbSNP
rs1187135893 351 dbSNP
rs997256994 355 dbSNP
rs1249555917 356 dbSNP
rs942470622 365 dbSNP
rs73426481 366 dbSNP
rs1482618275 374 dbSNP
rs1253756976 386 dbSNP
rs1212069818 393 dbSNP
rs891595524 394 dbSNP
rs1273634527 411 dbSNP
rs1011433149 419 dbSNP
rs1338662610 423 dbSNP
rs1296512458 424 dbSNP
rs367554239 427 dbSNP
rs1376989352 428 dbSNP
rs1304662425 429 dbSNP
rs1021513011 433 dbSNP
rs929608659 434 dbSNP
rs1370540300 436 dbSNP
rs1046737136 440 dbSNP
rs1431976324 446 dbSNP
rs1391195944 463 dbSNP
rs1170641231 472 dbSNP
rs527932564 488 dbSNP
rs980082794 490 dbSNP
rs1036093113 504 dbSNP
rs949290703 512 dbSNP
rs1251041631 518 dbSNP
rs1044914982 519 dbSNP
rs115577474 520 dbSNP
rs918692106 526 dbSNP
rs570643442 539 dbSNP
rs867919449 541 dbSNP
rs984242554 554 dbSNP
rs143028005 558 dbSNP
rs549784135 567 dbSNP
rs1415524102 570 dbSNP
rs942941870 572 dbSNP
rs182030848 580 dbSNP
rs1030265169 587 dbSNP
rs954986594 596 dbSNP
rs1412240661 599 dbSNP
rs1008191435 601 dbSNP
rs535390521 604 dbSNP
rs1293379749 605 dbSNP
rs1457084917 609 dbSNP
rs932975913 613 dbSNP
rs1052831791 620 dbSNP
rs776559781 624 dbSNP
rs1475226345 628 dbSNP
rs1410611485 630 dbSNP
rs554084330 636 dbSNP
rs1163686586 639 dbSNP
rs761129390 642 dbSNP
rs1483996319 646 dbSNP
rs867801945 651 dbSNP
rs919660735 654 dbSNP
rs1250962918 662 dbSNP
rs1011359542 668 dbSNP
rs1021875641 669 dbSNP
rs905731005 671 dbSNP
rs572140295 673 dbSNP
rs1234160298 674 dbSNP
rs779842504 679 dbSNP
rs982449048 680 dbSNP
rs1035615356 685 dbSNP
rs1325397355 687 dbSNP
rs1336933655 688 dbSNP
rs1300992501 695 dbSNP
rs539656287 699 dbSNP
rs1393367099 703 dbSNP
rs557865245 707 dbSNP
rs1318251535 708 dbSNP
rs751457627 721 dbSNP
rs576226992 723 dbSNP
rs34256107 725 dbSNP
rs1045385104 726 dbSNP
rs984259790 728 dbSNP
rs1271103648 734 dbSNP
rs1354506098 744 dbSNP
rs138693015 753 dbSNP
rs1431187353 758 dbSNP
rs1269222823 760 dbSNP
rs1211903336 771 dbSNP
rs911369939 771 dbSNP
rs555193436 773 dbSNP
rs1266303855 775 dbSNP
rs561677010 777 dbSNP
rs1351990505 779 dbSNP
rs1274736103 787 dbSNP
rs1231735257 789 dbSNP
rs1333129633 796 dbSNP
rs761774722 810 dbSNP
rs575029218 817 dbSNP
rs892567365 820 dbSNP
rs922867917 821 dbSNP
rs932943097 827 dbSNP
rs1187136577 847 dbSNP
rs1385084059 853 dbSNP
rs1401975848 853 dbSNP
rs1052757253 856 dbSNP
rs1464489195 858 dbSNP
rs542153796 864 dbSNP
rs560881591 873 dbSNP
rs1164653601 882 dbSNP
rs56244714 890 dbSNP
rs1367127394 892 dbSNP
rs890442433 896 dbSNP
rs1278021248 902 dbSNP
rs537483837 921 dbSNP
rs1199174850 925 dbSNP
rs1347828489 931 dbSNP
rs1281474340 934 dbSNP
rs1228190012 935 dbSNP
rs1340978064 935 dbSNP
rs34608947 937 dbSNP
rs1294890961 942 dbSNP
rs1432478408 945 dbSNP
rs1326439056 946 dbSNP
rs1333006981 953 dbSNP
rs1007847491 964 dbSNP
rs527865526 969 dbSNP
rs1163505367 982 dbSNP
rs1383568268 988 dbSNP
rs1377254711 989 dbSNP
rs1042820162 991 dbSNP
rs1428822930 993 dbSNP
rs1388113429 1001 dbSNP
rs14792 1003 dbSNP
rs1475865963 1006 dbSNP
rs1001396426 1012 dbSNP
rs963607572 1013 dbSNP
rs752214008 1021 dbSNP
rs1414167730 1025 dbSNP
rs995023586 1031 dbSNP
rs895725936 1032 dbSNP
rs1026447965 1038 dbSNP
rs1025595510 1040 dbSNP
rs1339732973 1055 dbSNP
rs1283066096 1057 dbSNP
rs1242034962 1062 dbSNP
rs1356849065 1069 dbSNP
rs184233599 1070 dbSNP
rs573834717 1073 dbSNP
rs531706496 1079 dbSNP
rs541120567 1082 dbSNP
rs1410732236 1097 dbSNP
rs917630465 1112 dbSNP
rs1161499982 1122 dbSNP
rs970781747 1123 dbSNP
rs964535457 1126 dbSNP
rs1482400456 1129 dbSNP
rs980742842 1138 dbSNP
rs559372195 1143 dbSNP
rs769980818 1146 dbSNP
rs751048074 1151 dbSNP
rs1288332220 1153 dbSNP
rs1207725827 1156 dbSNP
rs1288652157 1156 dbSNP
rs777868591 1157 dbSNP
rs1053552213 1159 dbSNP
rs1187945147 1162 dbSNP
rs1348619815 1163 dbSNP
rs1281046477 1169 dbSNP
rs189549592 1173 dbSNP
rs945497361 1179 dbSNP
rs367944606 1181 dbSNP
rs1043175819 1182 dbSNP
rs1321770283 1189 dbSNP
rs1052276203 1194 dbSNP
rs890483062 1197 dbSNP
rs574385041 1200 dbSNP
rs943350233 1200 dbSNP
rs749321761 1207 dbSNP
rs1187763681 1210 dbSNP
rs1039005097 1224 dbSNP
rs771521846 1236 dbSNP
rs899419648 1244 dbSNP
rs937118290 1245 dbSNP
rs1159896768 1256 dbSNP
rs995055997 1258 dbSNP
rs1056949048 1262 dbSNP
rs1026520224 1263 dbSNP
rs1315020391 1267 dbSNP
rs886604803 1275 dbSNP
rs1286206167 1288 dbSNP
rs1224292196 1289 dbSNP
rs1003990581 1292 dbSNP
rs1025132792 1293 dbSNP
rs1434008209 1304 dbSNP
rs774730233 1305 dbSNP
rs970475795 1309 dbSNP
rs1372067865 1321 dbSNP
rs568112518 1326 dbSNP
rs760051419 1332 dbSNP
rs1046972482 1337 dbSNP
rs980862747 1338 dbSNP
rs1033310083 1346 dbSNP
rs1160395968 1351 dbSNP
rs1414406418 1362 dbSNP
rs1423498103 1365 dbSNP
rs772591685 1366 dbSNP
rs1455287658 1373 dbSNP
rs750328766 1382 dbSNP
rs1018744788 1396 dbSNP
rs1187568597 1399 dbSNP
rs899901352 1406 dbSNP
rs989348324 1412 dbSNP
rs1396416168 1415 dbSNP
rs529331258 1418 dbSNP
rs998699090 1421 dbSNP
rs1216406962 1432 dbSNP
rs1311594544 1444 dbSNP
rs1277901543 1449 dbSNP
rs1335368573 1455 dbSNP
rs1348363829 1469 dbSNP
rs945191374 1478 dbSNP
rs775978029 1479 dbSNP
rs1380760507 1480 dbSNP
rs911976241 1500 dbSNP
rs1238334743 1513 dbSNP
rs956867491 1524 dbSNP
rs1447927206 1527 dbSNP
rs943430015 1532 dbSNP
rs1022572886 1533 dbSNP
rs1389967293 1536 dbSNP
rs534516827 1545 dbSNP
rs547361798 1552 dbSNP
rs1426371178 1562 dbSNP
rs181146926 1564 dbSNP
rs899159808 1574 dbSNP
rs930923801 1580 dbSNP
rs577825795 1582 dbSNP
rs1047990202 1587 dbSNP
rs1212964766 1597 dbSNP
rs539229072 1614 dbSNP
rs764977995 1623 dbSNP
rs756861412 1627 dbSNP
rs1273658681 1635 dbSNP
rs1014851159 1650 dbSNP
rs1250303362 1659 dbSNP
rs1225513530 1660 dbSNP
rs1309545481 1663 dbSNP
rs1296360431 1680 dbSNP
rs1024454901 1685 dbSNP
rs1437425147 1688 dbSNP
rs1227852516 1692 dbSNP
rs906275839 1694 dbSNP
rs558000343 1702 dbSNP
rs1315293640 1711 dbSNP
rs531321158 1711 dbSNP
rs552661654 1714 dbSNP
rs1415949554 1715 dbSNP
rs1370266272 1721 dbSNP
rs1306631078 1724 dbSNP
rs1374479210 1727 dbSNP
rs537144966 1727 dbSNP
rs186593348 1730 dbSNP
rs957698245 1731 dbSNP
rs147018355 1733 dbSNP
rs1189899715 1735 dbSNP
rs1379278777 1736 dbSNP
rs1466527176 1737 dbSNP
rs1297391986 1743 dbSNP
rs1046939061 1744 dbSNP
rs1020813215 1749 dbSNP
rs888383246 1757 dbSNP
rs1252068743 1769 dbSNP
rs966569540 1778 dbSNP
rs941303708 1781 dbSNP
rs1397919718 1783 dbSNP
rs987727676 1791 dbSNP
rs1444763015 1795 dbSNP
rs1333622034 1798 dbSNP
rs1039688978 1800 dbSNP
rs911697246 1801 dbSNP
rs1305273384 1802 dbSNP
rs943484609 1803 dbSNP
rs1397689402 1805 dbSNP
rs1298337417 1811 dbSNP
rs1460600387 1828 dbSNP
rs998246944 1829 dbSNP
rs372144593 1840 dbSNP
rs72880716 1844 dbSNP
rs920620920 1846 dbSNP
rs1179614347 1853 dbSNP
rs1299344232 1871 dbSNP
rs1214444395 1881 dbSNP
rs1275104423 1881 dbSNP
rs1467360225 1881 dbSNP
rs200910525 1881 dbSNP
rs930618293 1882 dbSNP
rs892615212 1883 dbSNP
rs1241825441 1884 dbSNP
rs1009752285 1885 dbSNP
rs1368392185 1886 dbSNP
rs1439693774 1886 dbSNP
rs554144953 1886 dbSNP
rs549789519 1888 dbSNP
rs950290198 1891 dbSNP
rs1383646938 1892 dbSNP
rs1156679422 1894 dbSNP
rs1251090525 1896 dbSNP
rs1456724199 1901 dbSNP
rs981470870 1920 dbSNP
rs545951874 1925 dbSNP
rs775284702 1927 dbSNP
rs906023019 1927 dbSNP
rs917012832 1935 dbSNP
rs138184305 1936 dbSNP
rs982566032 1950 dbSNP
rs1054782240 1966 dbSNP
rs1188920144 1967 dbSNP
rs1412100766 1972 dbSNP
rs1232605257 1974 dbSNP
rs1350541632 1982 dbSNP
rs561664816 1985 dbSNP
rs1441191307 1989 dbSNP
rs141746072 1996 dbSNP
rs1169675941 1999 dbSNP
rs1040059723 2006 dbSNP
rs1020551763 2017 dbSNP
rs967038443 2019 dbSNP
rs933997871 2025 dbSNP
rs1312235412 2027 dbSNP
rs1432582909 2031 dbSNP
rs755290065 2041 dbSNP
rs1008809601 2044 dbSNP
rs1019236044 2052 dbSNP
rs1475247921 2057 dbSNP
rs1051153977 2061 dbSNP
rs1195482358 2069 dbSNP
rs964559994 2071 dbSNP
rs543503655 2076 dbSNP
rs1009680853 2083 dbSNP
rs1486825048 2083 dbSNP
rs562246803 2091 dbSNP
rs1281495892 2095 dbSNP
rs1234561913 2103 dbSNP
rs1338408171 2107 dbSNP
rs756391145 2109 dbSNP
rs1228924655 2112 dbSNP
rs1326531430 2113 dbSNP
rs1291850981 2115 dbSNP
rs904055283 2150 dbSNP
rs1387791707 2155 dbSNP
rs1377044143 2177 dbSNP
rs952086965 2182 dbSNP
rs1313321785 2189 dbSNP
rs777955272 2198 dbSNP
rs1316400554 2214 dbSNP
rs1475753564 2222 dbSNP
rs749465263 2225 dbSNP
rs529252915 2226 dbSNP
rs547793261 2239 dbSNP
rs770916244 2242 dbSNP
rs1034348352 2249 dbSNP
rs1204322594 2250 dbSNP
rs1320741897 2254 dbSNP
rs189171261 2258 dbSNP
rs1270390812 2265 dbSNP
rs746415231 2266 dbSNP
rs1339401645 2269 dbSNP
rs772677712 2278 dbSNP
rs190314507 2283 dbSNP
rs776067826 2286 dbSNP
rs1357345192 2289 dbSNP
rs1293650390 2312 dbSNP
rs755905153 2314 dbSNP
rs181548002 2316 dbSNP
rs893573581 2317 dbSNP
rs1393823301 2321 dbSNP
rs1162948510 2327 dbSNP
rs1478789711 2329 dbSNP
rs1194075076 2338 dbSNP
rs1010571227 2339 dbSNP
rs753796957 2344 dbSNP
rs1042073482 2347 dbSNP
rs962865418 2351 dbSNP
rs902176320 2355 dbSNP
rs1009255367 2358 dbSNP
rs150553004 2361 dbSNP
rs1457983708 2363 dbSNP
rs1271967774 2365 dbSNP
rs139784643 2384 dbSNP
rs1336351622 2387 dbSNP
rs1404970028 2388 dbSNP
rs996029549 2394 dbSNP
rs537282553 2404 dbSNP
rs1481932340 2413 dbSNP
rs1418776650 2418 dbSNP
rs1209152945 2419 dbSNP
rs1257332670 2420 dbSNP
rs778568677 2421 dbSNP
rs1190340287 2425 dbSNP
rs1417395642 2429 dbSNP
rs1281133846 2434 dbSNP
rs1370820153 2434 dbSNP
rs1428018520 2436 dbSNP
rs1027450766 2440 dbSNP
rs749901243 2441 dbSNP
rs1374703187 2442 dbSNP
rs1432847518 2448 dbSNP
rs1172776350 2453 dbSNP
rs1375840244 2458 dbSNP
rs1443187802 2458 dbSNP
rs1416177938 2461 dbSNP
rs201097083 2467 dbSNP
rs779680180 2469 dbSNP
rs747457695 2471 dbSNP
rs1297166091 2473 dbSNP
rs1339878985 2474 dbSNP
rs1158933786 2476 dbSNP
rs1245604894 2481 dbSNP
rs1309769779 2486 dbSNP
rs769253950 2491 dbSNP
rs1279978067 2493 dbSNP
rs933925607 2495 dbSNP
rs1323454486 2496 dbSNP
rs1051077937 2501 dbSNP
rs567383064 2509 dbSNP
rs1187168351 2511 dbSNP
rs748549834 2514 dbSNP
rs374537214 2518 dbSNP
rs772744685 2521 dbSNP
rs1395398875 2525 dbSNP
rs1436386833 2548 dbSNP
rs1044208605 2553 dbSNP
rs552946698 2554 dbSNP
rs1454047643 2557 dbSNP
rs1290114688 2560 dbSNP
rs146332021 2564 dbSNP
rs1439273236 2567 dbSNP
rs377545207 2573 dbSNP
rs1189008654 2574 dbSNP
rs1372133014 2575 dbSNP
rs760510327 2576 dbSNP
rs1282667386 2577 dbSNP
rs1347509203 2581 dbSNP
rs1042103094 2584 dbSNP
rs902206190 2597 dbSNP
rs543078198 2599 dbSNP
rs558072843 2602 dbSNP
rs139558433 2605 dbSNP
rs1425237077 2623 dbSNP
rs368378451 2625 dbSNP
rs1158122572 2626 dbSNP
rs1484834834 2632 dbSNP
rs1243735556 2634 dbSNP
rs543639922 2647 dbSNP
rs1485185242 2675 dbSNP
rs751056944 2677 dbSNP
rs1421998540 2681 dbSNP
rs1236754844 2684 dbSNP
rs759508959 2686 dbSNP
rs1294910486 2688 dbSNP
rs1212842544 2693 dbSNP
rs996062233 2696 dbSNP
rs372174668 2702 dbSNP
rs1271224490 2704 dbSNP
rs951084174 2709 dbSNP
rs1374017839 2711 dbSNP
rs1027521081 2716 dbSNP
rs887605692 2717 dbSNP
rs1315250685 2720 dbSNP
rs1358908951 2730 dbSNP
rs547524255 2744 dbSNP
rs1286374462 2747 dbSNP
rs1004992602 2748 dbSNP
rs114137280 2749 dbSNP
rs971858847 2751 dbSNP
rs1421034304 2754 dbSNP
rs975639288 2756 dbSNP
rs1255108554 2767 dbSNP
rs1212809994 2775 dbSNP
rs186013835 2777 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 144110.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acggucGGAGCGGGUCg 5'
                |: | ||::| 
Target 5' ---ucuCUCCUCCUGGg 3'
 		1 - 14
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_153347 | 3UTR | GGCCCAGAUCCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000280734.2 | 3UTR | UCUCUCCUCCUGGGGCUGGGGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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