pre-miRNA Information | |
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pre-miRNA | hsa-mir-605 |
Genomic Coordinates | chr10: 51299573 - 51299655 |
Synonyms | MIRN605, hsa-mir-605, MIR605 |
Description | Homo sapiens miR-605 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-605-3p | ||||||||||||||||||||||||||||
Sequence | 51| AGAAGGCACUAUGAGAUUUAGA |72 | ||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |
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Gene Symbol | TET3 |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | hESCs (WA-09) |
Disease | 200424.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine
... - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development. |
Article |
- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al. - Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
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CLIP-seq Support 1 for dataset SRR359787 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | hESCs (WA-09) / 4-thiouridine, RNase T1 |
Location of target site | ENST00000409262.3 | 3UTR | UCUCACCAAGGUGACGAUGGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22012620 / SRX103431 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT061339 | WEE1 | WEE1 G2 checkpoint kinase | ![]() |
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2 | 4 | ||||||
MIRT061584 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 6 | ||||||
MIRT076140 | WDR81 | WD repeat domain 81 | ![]() |
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2 | 2 | ||||||
MIRT079361 | CCDC137 | coiled-coil domain containing 137 | ![]() |
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2 | 2 | ||||||
MIRT079547 | VAMP3 | vesicle associated membrane protein 3 | ![]() |
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2 | 2 | ||||||
MIRT096242 | CANX | calnexin | ![]() |
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2 | 2 | ||||||
MIRT243877 | G3BP1 | G3BP stress granule assembly factor 1 | ![]() |
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2 | 4 | ||||||
MIRT249186 | AKIRIN1 | akirin 1 | ![]() |
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2 | 8 | ||||||
MIRT273604 | SP1 | Sp1 transcription factor | ![]() |
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2 | 2 | ||||||
MIRT316766 | FOXC1 | forkhead box C1 | ![]() |
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2 | 4 | ||||||
MIRT322410 | PPP2R2A | protein phosphatase 2 regulatory subunit Balpha | ![]() |
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2 | 2 | ||||||
MIRT370117 | TRIB3 | tribbles pseudokinase 3 | ![]() |
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2 | 2 | ||||||
MIRT392725 | UBN2 | ubinuclein 2 | ![]() |
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2 | 2 | ||||||
MIRT406910 | PTBP1 | polypyrimidine tract binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT407440 | CTDSP1 | CTD small phosphatase 1 | ![]() |
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2 | 2 | ||||||
MIRT441887 | RD3 | retinal degeneration 3 | ![]() |
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2 | 4 | ||||||
MIRT444979 | C15orf52 | chromosome 15 open reading frame 52 | ![]() |
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2 | 2 | ||||||
MIRT445241 | FOXD4 | forkhead box D4 | ![]() |
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2 | 2 | ||||||
MIRT445500 | FOXD4L5 | forkhead box D4 like 5 | ![]() |
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2 | 2 | ||||||
MIRT445503 | FOXD4L4 | forkhead box D4 like 4 | ![]() |
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2 | 2 | ||||||
MIRT447025 | FOXD4L1 | forkhead box D4 like 1 | ![]() |
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2 | 2 | ||||||
MIRT447743 | TMCC3 | transmembrane and coiled-coil domain family 3 | ![]() |
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2 | 2 | ||||||
MIRT448761 | HDX | highly divergent homeobox | ![]() |
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2 | 2 | ||||||
MIRT450003 | HAX1 | HCLS1 associated protein X-1 | ![]() |
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2 | 2 | ||||||
MIRT452830 | FAM131B | family with sequence similarity 131 member B | ![]() |
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2 | 2 | ||||||
MIRT452872 | LAX1 | lymphocyte transmembrane adaptor 1 | ![]() |
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2 | 2 | ||||||
MIRT453506 | ARRB1 | arrestin beta 1 | ![]() |
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2 | 2 | ||||||
MIRT454169 | HIST1H2BK | histone cluster 1 H2B family member k | ![]() |
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2 | 2 | ||||||
MIRT458742 | CES2 | carboxylesterase 2 | ![]() |
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2 | 2 | ||||||
MIRT459166 | HSPA6 | heat shock protein family A (Hsp70) member 6 | ![]() |
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2 | 21 | ||||||
MIRT460246 | IL17RB | interleukin 17 receptor B | ![]() |
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2 | 4 | ||||||
MIRT460514 | SDE2 | SDE2 telomere maintenance homolog | ![]() |
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2 | 2 | ||||||
MIRT460698 | RNF157 | ring finger protein 157 | ![]() |
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2 | 2 | ||||||
MIRT461481 | METTL1 | methyltransferase like 1 | ![]() |
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2 | 2 | ||||||
MIRT462617 | C20orf27 | chromosome 20 open reading frame 27 | ![]() |
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2 | 4 | ||||||
MIRT463233 | ZNF131 | zinc finger protein 131 | ![]() |
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2 | 2 | ||||||
MIRT465699 | TNPO2 | transportin 2 | ![]() |
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2 | 8 | ||||||
MIRT466304 | TIMM22 | translocase of inner mitochondrial membrane 22 | ![]() |
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2 | 2 | ||||||
MIRT468957 | RPS14 | ribosomal protein S14 | ![]() |
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2 | 6 | ||||||
MIRT469571 | RARA | retinoic acid receptor alpha | ![]() |
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2 | 2 | ||||||
MIRT469685 | RAB5B | RAB5B, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT470800 | PMP22 | peripheral myelin protein 22 | ![]() |
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2 | 2 | ||||||
MIRT471649 | PANK2 | pantothenate kinase 2 | ![]() |
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2 | 4 | ||||||
MIRT471722 | OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1 | ![]() |
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2 | 2 | ||||||
MIRT472281 | NFIB | nuclear factor I B | ![]() |
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2 | 4 | ||||||
MIRT473680 | MAPKBP1 | mitogen-activated protein kinase binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT475859 | H6PD | hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase | ![]() |
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2 | 2 | ||||||
MIRT477326 | EPHA2 | EPH receptor A2 | ![]() |
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2 | 2 | ||||||
MIRT477831 | DYRK3 | dual specificity tyrosine phosphorylation regulated kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT478572 | CTNND1 | catenin delta 1 | ![]() |
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2 | 4 | ||||||
MIRT479634 | CD81 | CD81 molecule | ![]() |
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2 | 2 | ||||||
MIRT481950 | ANKRD11 | ankyrin repeat domain 11 | ![]() |
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2 | 2 | ||||||
MIRT483696 | ZNF74 | zinc finger protein 74 | ![]() |
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2 | 6 | ||||||
MIRT488798 | MALT1 | MALT1 paracaspase | ![]() |
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2 | 2 | ||||||
MIRT489066 | STARD3 | StAR related lipid transfer domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT492533 | PSMD11 | proteasome 26S subunit, non-ATPase 11 | ![]() |
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2 | 2 | ||||||
MIRT492857 | NRARP | NOTCH regulated ankyrin repeat protein | ![]() |
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2 | 2 | ||||||
MIRT496793 | BTRC | beta-transducin repeat containing E3 ubiquitin protein ligase | ![]() |
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2 | 2 | ||||||
MIRT500122 | ZNF106 | zinc finger protein 106 | ![]() |
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2 | 4 | ||||||
MIRT505359 | TMEM167A | transmembrane protein 167A | ![]() |
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2 | 2 | ||||||
MIRT506786 | KLHL15 | kelch like family member 15 | ![]() |
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2 | 6 | ||||||
MIRT510692 | SRM | spermidine synthase | ![]() |
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2 | 6 | ||||||
MIRT515841 | CEP104 | centrosomal protein 104 | ![]() |
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2 | 4 | ||||||
MIRT516448 | ADAMTS4 | ADAM metallopeptidase with thrombospondin type 1 motif 4 | ![]() |
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2 | 4 | ||||||
MIRT528855 | PKP1 | plakophilin 1 | ![]() |
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2 | 2 | ||||||
MIRT533848 | TET3 | tet methylcytosine dioxygenase 3 | ![]() |
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2 | 2 | ||||||
MIRT539025 | ATXN7L1 | ataxin 7 like 1 | ![]() |
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2 | 4 | ||||||
MIRT542872 | NR6A1 | nuclear receptor subfamily 6 group A member 1 | ![]() |
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2 | 2 | ||||||
MIRT546543 | SATB2 | SATB homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT554114 | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | ![]() |
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2 | 2 | ||||||
MIRT560569 | ZNF460 | zinc finger protein 460 | ![]() |
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2 | 2 | ||||||
MIRT560796 | EPM2AIP1 | EPM2A interacting protein 1 | ![]() |
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2 | 2 | ||||||
MIRT562836 | GCFC2 | GC-rich sequence DNA-binding factor 2 | ![]() |
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2 | 2 | ||||||
MIRT563109 | IFRD2 | interferon related developmental regulator 2 | ![]() |
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2 | 2 | ||||||
MIRT564177 | MRPL49 | mitochondrial ribosomal protein L49 | ![]() |
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2 | 2 | ||||||
MIRT564283 | ASB1 | ankyrin repeat and SOCS box containing 1 | ![]() |
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2 | 2 | ||||||
MIRT564350 | USP22 | ubiquitin specific peptidase 22 | ![]() |
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2 | 2 | ||||||
MIRT565279 | TNFRSF21 | TNF receptor superfamily member 21 | ![]() |
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2 | 2 | ||||||
MIRT565338 | TMEM104 | transmembrane protein 104 | ![]() |
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2 | 2 | ||||||
MIRT565905 | SCAMP2 | secretory carrier membrane protein 2 | ![]() |
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2 | 2 | ||||||
MIRT567108 | ITGB1 | integrin subunit beta 1 | ![]() |
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2 | 2 | ||||||
MIRT567601 | FANCF | Fanconi anemia complementation group F | ![]() |
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2 | 2 | ||||||
MIRT567779 | DGAT2 | diacylglycerol O-acyltransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT568075 | CENPQ | centromere protein Q | ![]() |
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2 | 2 | ||||||
MIRT624304 | COL12A1 | collagen type XII alpha 1 chain | ![]() |
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2 | 2 | ||||||
MIRT644395 | CDKL1 | cyclin dependent kinase like 1 | ![]() |
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2 | 2 | ||||||
MIRT661547 | ZNF674 | zinc finger protein 674 | ![]() |
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2 | 4 | ||||||
MIRT670949 | IRAK3 | interleukin 1 receptor associated kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT672951 | AKAP5 | A-kinase anchoring protein 5 | ![]() |
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2 | 2 | ||||||
MIRT697426 | ZFP36 | ZFP36 ring finger protein | ![]() |
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2 | 2 | ||||||
MIRT700793 | PIAS2 | protein inhibitor of activated STAT 2 | ![]() |
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2 | 2 | ||||||
MIRT702657 | ITGA3 | integrin subunit alpha 3 | ![]() |
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2 | 2 | ||||||
MIRT708945 | FZR1 | fizzy and cell division cycle 20 related 1 | ![]() |
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2 | 2 | ||||||
MIRT713657 | PLCE1 | phospholipase C epsilon 1 | ![]() |
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2 | 2 | ||||||
MIRT719239 | CYSLTR2 | cysteinyl leukotriene receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT719951 | BLOC1S6 | biogenesis of lysosomal organelles complex 1 subunit 6 | ![]() |
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2 | 2 | ||||||
MIRT722048 | HLA-E | major histocompatibility complex, class I, E | ![]() |
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2 | 2 | ||||||
MIRT722201 | URM1 | ubiquitin related modifier 1 | ![]() |
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2 | 2 | ||||||
MIRT724790 | C1D | C1D nuclear receptor corepressor | ![]() |
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2 | 2 | ||||||
MIRT734347 | CYP2B6 | cytochrome P450 family 2 subfamily B member 6 | ![]() |
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3 | 0 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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