pre-miRNA Information
pre-miRNA hsa-mir-4753   
Genomic Coordinates chr1: 235190034 - 235190116
Description Homo sapiens miR-4753 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4753-5p
Sequence 10| CAAGGCCAAAGGAAGAGAACAG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs547986869 3 dbSNP
rs1007787337 7 dbSNP
rs1224263160 12 dbSNP
rs1256249071 13 dbSNP
rs1484015538 14 dbSNP
rs535678819 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TAF1D   
Synonyms JOSD3, RAFI41, TAF(I)41, TAFI41
Description TATA-box binding protein associated factor, RNA polymerase I subunit D
Transcript NM_024116   
Expression
Putative miRNA Targets on TAF1D
3'UTR of TAF1D
(miRNA target sites are highlighted)
>TAF1D|NM_024116|3'UTR
   1 CAGGATCATGAATGTCAAAGGTGAAGCATATAGAAAAAACGACTTCATAGAAATGAATAAAGATAAATGTGGATATATGT
  81 ACCAGTCTGGTGGTGAAGAAATTCTGAAACCCAGAACTTTATAACAAGAAAAAAAATTTTTAACCCTGTGAAGAAGTTTG
 161 TGAAAGAAACTTGTGAAGTAGTAATAATTAGAAAAAAAACCATTAAAACACCAGAGAAAATACATAGAAAAAAAAAAAAA
 241 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacaAGAGAAGG--AAACCGgaac 5'
              | | | ||  | |||:    
Target 5' gataTATGTACCAGTCTGGTggtg 3'
72 - 95 72.00 -5.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30120347 15 COSMIC
COSN28186728 39 COSMIC
COSN31559267 60 COSMIC
COSN30487395 83 COSMIC
COSN26414229 96 COSMIC
COSN26414577 97 COSMIC
COSN30246231 100 COSMIC
COSN30180982 128 COSMIC
COSN8585043 129 COSMIC
COSN31513775 130 COSMIC
COSN31600353 134 COSMIC
COSN31537915 135 COSMIC
COSN13358298 137 COSMIC
COSN30111850 166 COSMIC
COSN30126432 222 COSMIC
COSN32134021 298 COSMIC
COSN5312372 335 COSMIC
COSN32064486 403 COSMIC
COSN29580179 486 COSMIC
COSN8879182 533 COSMIC
COSN10094700 559 COSMIC
COSN20243864 589 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1366631421 1 dbSNP
rs1162784798 9 dbSNP
rs1032849115 10 dbSNP
rs1371535847 12 dbSNP
rs1236038702 14 dbSNP
rs373782857 17 dbSNP
rs1283496648 18 dbSNP
rs777761872 21 dbSNP
rs772106590 22 dbSNP
rs1463692382 26 dbSNP
rs748163425 27 dbSNP
rs779038029 29 dbSNP
rs1470267853 31 dbSNP
rs755030154 32 dbSNP
rs1243442396 33 dbSNP
rs897917918 34 dbSNP
rs550189701 35 dbSNP
rs377763823 40 dbSNP
rs753615994 40 dbSNP
rs150792429 41 dbSNP
rs750751674 46 dbSNP
rs187258869 47 dbSNP
rs767934267 50 dbSNP
rs758421732 63 dbSNP
rs1174732988 68 dbSNP
rs1195712011 68 dbSNP
rs900157968 72 dbSNP
rs1433133503 73 dbSNP
rs1469656484 74 dbSNP
rs1159224185 81 dbSNP
rs909257726 82 dbSNP
rs1265807980 85 dbSNP
rs1179347920 87 dbSNP
rs775209946 96 dbSNP
rs1048293498 99 dbSNP
rs937940457 102 dbSNP
rs926441403 103 dbSNP
rs982365155 105 dbSNP
rs929128272 107 dbSNP
rs138069553 110 dbSNP
rs369538505 110 dbSNP
rs1039233990 112 dbSNP
rs1353727178 114 dbSNP
rs185591721 117 dbSNP
rs1469149150 118 dbSNP
rs890655559 120 dbSNP
rs543075610 121 dbSNP
rs1325919557 126 dbSNP
rs1263893226 127 dbSNP
rs545151141 131 dbSNP
rs779406488 134 dbSNP
rs929420798 135 dbSNP
rs920855309 136 dbSNP
rs1164066252 137 dbSNP
rs1418524378 137 dbSNP
rs1462755294 137 dbSNP
rs1329058738 142 dbSNP
rs193250273 145 dbSNP
rs1391606028 154 dbSNP
rs1330519934 157 dbSNP
rs1375931221 158 dbSNP
rs1232175755 159 dbSNP
rs1293171506 163 dbSNP
rs1037949561 168 dbSNP
rs898018116 170 dbSNP
rs1454303540 179 dbSNP
rs1406283548 180 dbSNP
rs574035419 181 dbSNP
rs560189678 188 dbSNP
rs1339217488 189 dbSNP
rs1196576681 191 dbSNP
rs750517975 192 dbSNP
rs982635289 194 dbSNP
rs970800487 199 dbSNP
rs1006297493 200 dbSNP
rs1440729659 200 dbSNP
rs1464067573 200 dbSNP
rs913963674 211 dbSNP
rs988604765 212 dbSNP
rs1476138634 213 dbSNP
rs955836444 216 dbSNP
rs1032922601 219 dbSNP
rs1380144169 222 dbSNP
rs1177144245 226 dbSNP
rs1462349556 229 dbSNP
rs1169237529 242 dbSNP
rs187738453 251 dbSNP
rs1413560398 257 dbSNP
rs1243905047 260 dbSNP
rs1199965973 267 dbSNP
rs1356883837 270 dbSNP
rs964756044 271 dbSNP
rs1017257106 283 dbSNP
rs529926059 288 dbSNP
rs937909371 290 dbSNP
rs1346007648 300 dbSNP
rs1210505241 303 dbSNP
rs1281122300 311 dbSNP
rs905092631 312 dbSNP
rs949238179 319 dbSNP
rs1352886409 330 dbSNP
rs779062788 332 dbSNP
rs537613424 336 dbSNP
rs1247818156 337 dbSNP
rs1433703245 341 dbSNP
rs1173954425 342 dbSNP
rs1376712800 348 dbSNP
rs1417380717 349 dbSNP
rs890213281 350 dbSNP
rs1047479910 352 dbSNP
rs1383070031 352 dbSNP
rs1369327269 353 dbSNP
rs35590570 358 dbSNP
rs1233799526 360 dbSNP
rs1383117599 369 dbSNP
rs34235357 370 dbSNP
rs1350081016 371 dbSNP
rs987851131 374 dbSNP
rs1486162294 400 dbSNP
rs936413870 406 dbSNP
rs993700807 409 dbSNP
rs1386547019 414 dbSNP
rs1193859499 415 dbSNP
rs899329631 426 dbSNP
rs1396533418 427 dbSNP
rs141888800 428 dbSNP
rs1157745929 432 dbSNP
rs1437202866 432 dbSNP
rs1345327155 433 dbSNP
rs138768639 437 dbSNP
rs938265808 440 dbSNP
rs1392708263 442 dbSNP
rs1440657769 461 dbSNP
rs77042580 476 dbSNP
rs953096173 479 dbSNP
rs182766439 480 dbSNP
rs546091486 482 dbSNP
rs1306370159 483 dbSNP
rs913992945 485 dbSNP
rs1241063892 486 dbSNP
rs1271251968 489 dbSNP
rs1467831873 490 dbSNP
rs572555444 492 dbSNP
rs976394452 494 dbSNP
rs1491028438 499 dbSNP
rs372742675 500 dbSNP
rs1187155267 501 dbSNP
rs536943766 502 dbSNP
rs988175226 502 dbSNP
rs955912049 505 dbSNP
rs925790139 506 dbSNP
rs1161940353 512 dbSNP
rs1416374318 515 dbSNP
rs1461191543 520 dbSNP
rs1327011697 526 dbSNP
rs1487925850 527 dbSNP
rs887873551 531 dbSNP
rs979114310 536 dbSNP
rs964671780 537 dbSNP
rs1001479163 539 dbSNP
rs1393242709 553 dbSNP
rs753738283 557 dbSNP
rs1359944416 562 dbSNP
rs59651246 568 dbSNP
rs1274806579 569 dbSNP
rs954353052 570 dbSNP
rs1203346964 574 dbSNP
rs1026108640 578 dbSNP
rs536195414 579 dbSNP
rs949335550 580 dbSNP
rs1295687711 582 dbSNP
rs892261308 589 dbSNP
rs1340483072 590 dbSNP
rs554270256 595 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 79101.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000448108.2 | 3UTR | AUGUUAUGAUGAUGGGCGAAAUGUUCAACUGCUCUGAAGGGGCUGAAUGAAAAUGGCCUUUCUGAACAUCCAUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4753-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064916 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT161166 SLC25A36 solute carrier family 25 member 36 2 2
MIRT285542 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT308266 LRIG1 leucine rich repeats and immunoglobulin like domains 1 2 2
MIRT311425 LMNB1 lamin B1 2 2
MIRT373989 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT383141 CRY2 cryptochrome circadian clock 2 2 2
MIRT405243 ADIPOR2 adiponectin receptor 2 2 2
MIRT441620 ROCK1 Rho associated coiled-coil containing protein kinase 1 2 6
MIRT441789 SRPK1 SRSF protein kinase 1 2 2
MIRT441804 NOC3L NOC3 like DNA replication regulator 2 2
MIRT441832 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442005 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT442411 LIMD1 LIM domains containing 1 2 2
MIRT442708 UBE4B ubiquitination factor E4B 2 2
MIRT442714 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT442738 SERINC5 serine incorporator 5 2 2
MIRT442793 CEP170 centrosomal protein 170 2 2
MIRT442984 ZNF736 zinc finger protein 736 2 2
MIRT443055 THRB thyroid hormone receptor beta 2 2
MIRT443288 ZC3H12A zinc finger CCCH-type containing 12A 2 2
MIRT443325 SLC35G1 solute carrier family 35 member G1 2 2
MIRT443331 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT443593 ZNF439 zinc finger protein 439 2 4
MIRT443696 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT443748 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT443866 HDLBP high density lipoprotein binding protein 2 2
MIRT461185 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT464074 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT468738 SDC4 syndecan 4 2 2
MIRT470540 COASY Coenzyme A synthase 2 2
MIRT476458 GBA2 glucosylceramidase beta 2 2 2
MIRT479470 CDK6 cyclin dependent kinase 6 2 2
MIRT486351 TACC2 transforming acidic coiled-coil containing protein 2 2 8
MIRT495126 CXorf67 chromosome X open reading frame 67 2 2
MIRT495166 CNGA2 cyclic nucleotide gated channel alpha 2 2 4
MIRT495432 ATG7 autophagy related 7 2 2
MIRT495922 FBXO41 F-box protein 41 2 2
MIRT496572 DGCR6L DiGeorge syndrome critical region gene 6 like 2 2
MIRT498277 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT498431 DDX39A DExD-box helicase 39A 2 2
MIRT530149 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530313 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT530880 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT531177 ZNF626 zinc finger protein 626 2 2
MIRT533395 TYRP1 tyrosinase related protein 1 2 2
MIRT533709 TMEM64 transmembrane protein 64 2 2
MIRT533954 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT535616 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT539472 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT542878 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT559077 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT559465 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT561233 ZNF772 zinc finger protein 772 2 2
MIRT563477 POLE3 DNA polymerase epsilon 3, accessory subunit 2 2
MIRT563995 SLFN11 schlafen family member 11 2 2
MIRT564222 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT566017 RHOA ras homolog family member A 2 2
MIRT566028 RFX1 regulatory factor X1 2 2
MIRT566591 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT567874 CTDSP1 CTD small phosphatase 1 2 2
MIRT568552 AKT2 AKT serine/threonine kinase 2 2 2
MIRT569357 EFHC1 EF-hand domain containing 1 2 2
MIRT569973 DNAAF2 dynein axonemal assembly factor 2 2 2
MIRT614423 ZNF440 zinc finger protein 440 2 2
MIRT628831 SLC25A34 solute carrier family 25 member 34 2 2
MIRT630142 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT634479 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT634498 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT637394 R3HDM2 R3H domain containing 2 2 2
MIRT641840 TCF7L2 transcription factor 7 like 2 2 2
MIRT644397 CDKL1 cyclin dependent kinase like 1 2 2
MIRT644888 C2orf50 chromosome 2 open reading frame 50 2 2
MIRT647124 ZNF446 zinc finger protein 446 2 2
MIRT647420 SSTR3 somatostatin receptor 3 2 2
MIRT650297 PYCARD PYD and CARD domain containing 2 2
MIRT655488 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT658185 FBXO9 F-box protein 9 2 2
MIRT660931 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT665317 ZBTB3 zinc finger and BTB domain containing 3 2 2
MIRT670350 C1orf106 chromosome 1 open reading frame 106 2 4
MIRT670823 NICN1 nicolin 1 2 2
MIRT671825 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT672732 NETO2 neuropilin and tolloid like 2 2 2
MIRT674841 GLRX2 glutaredoxin 2 2 2
MIRT675930 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT686786 AZF1 azoospermia factor 1 2 2
MIRT697723 USP8 ubiquitin specific peptidase 8 2 2
MIRT702357 KLHL26 kelch like family member 26 2 2
MIRT704361 DBR1 debranching RNA lariats 1 2 2
MIRT709242 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT714433 SNED1 sushi, nidogen and EGF like domains 1 2 2
MIRT717000 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT720875 ADCY5 adenylate cyclase 5 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4753 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4753-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4753-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4753-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4753-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4753-5p Platinum 23939 resistant tissue
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission