miRTarBase - #MIRT534288


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pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLAIN2   
Synonyms KIAA1458
Description SLAIN motif family member 2
Transcript NM_020846   
Expression
Putative miRNA Targets on SLAIN2
3'UTR of SLAIN2
(miRNA target sites are highlighted)		 
>SLAIN2|NM_020846|3'UTR
   1 CCAGCAAAGACAAGAATGCAGAAGTCCACGGCTTCATGGATACCCTTCACCAGGCTAAAAAACAACTTTTATATGCAGAC
  81 TGTTCAGATAAGACTCTTGGGATTTATAAAATCCCAGCCCTCTCTGTCTTAATTAGCACAAACCGACAGAGATCATCAAA
 161 CAGCACTTTAATGACATTTAACATCAGATGTGTTTGGTAATCATACAATCACTCTCCATAGAATCACTTTTAGTTTTGTT
 241 TAATAGAAACTAGGTTGATTTTTAAAAAATATTTGACAGAGGCCAATATCTGGGCAAATACCTAATGGATGCCAAAGAGA
 321 AATGCCCATTTGTAAATGAGAAAAATGCCCATTTGTGCACAAGAAAATGGTGAATTCAGGCTATCCAAAACTTCACATTC
 401 AACCTAATTTACTGTATAAATAGTATCAATAAATATTTGTGTTAATGAGAACTAATATTCTGACTAATTATCTAAAGTGT
 481 TTCACTAGTACACCAGGAAACTACAGATTGAGATTAGGGGGTGGGAGGAAAGAAACCTGGGCTAGAGATTAAAACATTCC
 561 TAAATTTAGCAGAATTTCAGAAATGATTTTTGCAGATTCATTAGAAAAGAAAAATTGTCATTTAATCTTAAGTTTTGGAT
 641 GTAGCTCACATGTCACCACCACCAGATAGTGTTACAGCATGTATCCATCATGTTGCATTGACACATCAAACTTGTGTGTG
 721 TTTGTTTTGATTGCCAAAAGGGCTTAATATCAGTTGTACAATCTTTCTGAACTTTATAGTTCCTGGCTCAGGAAAGATGG
 801 CCTTTGCTATTGAAGCCAACTTCTTCACATGCTGTTATCTTTACAGAACTAAGAGATCTTGTTTCTATTAGCAGGTTTTC
 881 ATGATAGGAAAGAACAAGTAGTGTGTGTCTTTATTCTTGATACAACACCACCTCGGTGCTTGCAACCTGGAACAAAACCA
 961 TACCATGAGAGAGAGGGGGAAAAAAATCTATGCACTTAACCTACAAAATCTCTGGTGATGACAGTTGTATTGTTGCTATT
1041 ACATGGCATAACGGTCTATTATGTGGTAGGAAAATATAGCCTGCTAAATCCTACTTAAGTTGATCCACTTTAAACTGAGT
1121 AACTGTATAAAACATCTATTGAAAATTCTTTTCCTTTTGACTTAGATTCTGCCTTACATCAATTTTTGCATTTTTGGTAA
1201 AAAAAAAACCCTACTACGTATGACTCTAACCTGATACTTGCTCTCTAATGGCTCTTAATATATCCTTGAAATCGGCTATT
1281 TCAATTTTATCAGACTTTTACCAGAGTAAAACTTGCTTCTGTAGCAGGCCTCTCATTTTTTATTATGAGGTCTGTTTTTA
1361 AATACTTAATTTGAACAGCTCTAAGATATTGTCACTTAGGTCATCTAAAAGCTTTTAGAGATTTGAACATAAGTTCATTT
1441 CCTGTTAATCAAAGACATTCCGTAAGTTGGCAAAAGAAATTGGGAGAGAGAAATAGAAGGCTTGATATTCTGGACAGCAT
1521 TAAGGTTGATAGGTTGATGATAAAAACTTAAAACCAGGACCTCCATTCTGTCATGACTGACACCATGGTAGTCTGTCAGC
1601 TTGACCAGTGGAGAGTCATTCATTTAGCACAAGCAGCTGGAGATTTAAACTGCCAGTACTATGTATTTGGTGTATAATGC
1681 AAGGAAGAAACTTTATCCTTGAATTTGAGGGTGATGGGGTGGGTCAGGAAAGGATGGCGCCAGAATTCTACATGATAATG
1761 AACTAAAAAATGTTGCTTTTCAGAGGAAGATAAAGCATCTTCTTTTGGGAGGGGGGTATCTCATGTCTAAGTAAGTAAAA
1841 GAAAGAAGTAGCTACTGTCTCTTTTAAAAACCACGTACAAAACAGAACAAGTCTCAGTTTTCAGTGCAACATTTCAAAAA
1921 ATATATATGCTGCAATCTAATAATTAAAAGGAATTTTACCTATTATGAAACATATTACATTTTTTAAGTTAGATAATCAG
2001 TTTCAAAAGGAGTATTCAGGTTATTTAACTTTGTTTTTAAATGGCTGCATCAGAAAAAAATGTCTATTTTTTTTTATTAA
2081 AATATTTCATCACTTGTTAAAACATATTTTTGATCTGAGTTTGGTAAAGTATTATTTTACCTGCTGTTGTACTACCACAG
2161 ACTGTTGACTTTTAGTTTCTTAAAGAGAAAAATTGCCTTTTTACTAGAAAGCCTTTGTATATTGCAATTTTTCTGTTTGG
2241 GAAAATCTAAGGATTTACTGTGGTTAGTCTTACAGAAGAAATGTGGATTTGATAAACTAGTGCCTATGATTTTAACTTAT
2321 GTTTGATATATAGTAGTAAGGGTTTTATGAATGTTGATTATTTTGTGCCAACAGCCCAGAATTGTCACTTATATGTAAGC
2401 AGAAAACAATGAGCTCTGCTTCCAAAGTTATTTAATTTTCTCAGTGTTTGAATGTTATTTTTTGTAAGTGTGTTAATAAA
2481 AGTGTAAAGAATTGGAAAAAATATAAATATTCTTAACTCAAGCATTTGCTGGATCATTTTTCTACAAAACTTGTTTGTAC
2561 AATATAAAACACTCTCTGAAGAGTTGACTTTTTTTCAGTTTCGTATCCTGGAAATCACATTTTGTAAAACTGGGGACCAT
2641 TCATAATTGTCAGATACTTTTTAAAATTATCTCAATACATCACTTTTATAAAAAAAAAAAGTTTTTTTGAAAGAAAATTA
2721 GATACATATGTGGCCCCAGATGTTTGTATAACTCTAGAATGATCTAGACTATGTATGTTTAAATTAACTTTTTATTGAAT
2801 GTACAGGTGTCCATTTTTGACGTTAAGCATGGTCCTTTAAGGTCACATGACGTTTGATTTGCAAACATTTCTATAGCCGA
2881 ACTTGTATATGTGGTTGCCTCCTTAATAAACAGCCTGACCATAATGTTTATTATTAAATTTATATTCTTTAAGTGTTTAA
2961 TTAATCTCTGGATATGGTAAGATTCCTTTTTTCCTCTCAGTTGCCTACACTTGGTTTTAATAAATTACTCAGTTGAGTTT
3041 TTCTTTAACCACAGAAACCCAAATCATATTGCCCTTTCAGATTTAGTCTTCATGGGGTTGGATTATGTCTTATATTTTCT
3121 CTGTCAGAGTTATTTCATATATGGATTTTACTTGAAGGAAATTTACAGTTTACTCTAAATTGATTTGTTCTTGGAACTTT
3201 TTTACCTGCTGTGAATTGATACCTAGTTATAAAAAGCTAGCATTTGCCTAGATCATAACTATGTATGGTATCTAGTTAGA
3281 AAAAAACAAGCAAAAAGCTATTATGAGTTTCCAAGAGGGACAATTAATGCATTTTCATACCAAATGCGAATATTTAGGTG
3361 ATCACGTGCATCTTTTCTTGTATGGATGGAAAAATCAAGAATTGTACACTGTTTAATGAGTTCTCCATATTCCTTTAGGA
3441 GATATTTGCTTTGCAATTACATGTTACAATTAGAATAATTACAATTAAAATAATATTACATGTTACAATTAGATTAATAG
3521 TGATGAGAGGGAAAAAAGACACCCTTCTGTTTTTTTCTCTCAAGCCAGTCTAAAAACTTGAAGAGCCATTTAAAATTAAA
3601 TGTCACTATACTTGTATTATAAATCAATACATAAGTTTAAACCTGTTATATACTCAGTGCAACAGAAAAACCCATATGGA
3681 GGTTCAACCACTGATGTATTTTGAATGATCCTAAATATAAGTCTTGGGTGGCTAAATGGCCCTCTGCTTACCAGTCTGAA
3761 AATGAAACCGATTATACTCATCGGCCTTATTTACTGTAATACAAACTGGTTAAAACTATGTTAACTGAATGCTAGTTTGA
3841 AACAAATTATCTACATTAAGTCATCTTAATGTTTTCTCTTTAAAAGAAATAAAAAAATCTGTTTCTTCTGATTTCGAAAG
3921 TAATAGAAACTCTGCTGTAGAACATAAACTAAAAATATTAAAAAGTATAAAGGTAAAAAATGATAGTTGTCTGCAATCCC
4001 ATAATCCGGAAATATTGAAGTACTGTCCGTAACATGGTTATGACATGTTAAGTGGAAGGGTAGAAGGTCTTTTTTTTTTT
4081 AAGGAGAAAATGTTTCTTTTAAATAAATGTTTCTTATGTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgguUCCCUUACCGUCCCUUUa 5'
              || | |||  ||||||| 
Target 5' taatAGTG-ATGAGAGGGAAAa 3'
 3515 - 3535 153.00 -10.60
2 
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            || | ||: |  :|||||| 
Target 5' acCATGAGAGAGAGGGGGAAAa 3'
 962 - 983 140.00 -13.30
3 
miRNA  3' cgguUCCCUUACCGUCCCUUUa 5'
              ||||::||| ||| ||: 
Target 5' gattAGGGGGTGGGAGGAAAGa 3'
 512 - 533 126.00 -20.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14114451 52 COSMIC
COSN30138934 63 COSMIC
COSN25890023 264 COSMIC
COSN23570451 450 COSMIC
COSN19550425 936 COSMIC
COSN20100038 1209 COSMIC
COSN28202113 1330 COSMIC
COSN25800973 2369 COSMIC
COSN6833941 2393 COSMIC
COSN27195358 2701 COSMIC
COSN26765519 2804 COSMIC
COSN24223799 2853 COSMIC
COSN27568886 3784 COSMIC
COSN25466804 4010 COSMIC
COSN27445531 4081 COSMIC
COSN28985396 4081 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1444434387 15 dbSNP
rs751133012 19 dbSNP
rs147593344 22 dbSNP
rs766915580 23 dbSNP
rs375571223 24 dbSNP
rs756687611 26 dbSNP
rs1419092110 30 dbSNP
rs780767585 31 dbSNP
rs1404099427 37 dbSNP
rs975652143 39 dbSNP
rs921550224 40 dbSNP
rs1295255771 41 dbSNP
rs1340041496 45 dbSNP
rs749829346 51 dbSNP
rs142036147 64 dbSNP
rs1340204568 70 dbSNP
rs185822384 79 dbSNP
rs879045086 80 dbSNP
rs528532972 93 dbSNP
rs1452691425 98 dbSNP
rs761764785 100 dbSNP
rs940126466 116 dbSNP
rs1417919989 121 dbSNP
rs1357177828 132 dbSNP
rs1396281267 143 dbSNP
rs1038293733 145 dbSNP
rs1216199406 146 dbSNP
rs1273637225 147 dbSNP
rs898510760 155 dbSNP
rs372469639 159 dbSNP
rs1306666545 162 dbSNP
rs1055048825 167 dbSNP
rs896418437 177 dbSNP
rs769874345 187 dbSNP
rs1317460956 188 dbSNP
rs1296565226 190 dbSNP
rs1214896540 201 dbSNP
rs546630410 209 dbSNP
rs571424541 213 dbSNP
rs1272906311 226 dbSNP
rs756433215 227 dbSNP
rs34144414 228 dbSNP
rs1184277768 231 dbSNP
rs756877539 235 dbSNP
rs1327265128 244 dbSNP
rs1463614635 253 dbSNP
rs902240055 255 dbSNP
rs1000622291 257 dbSNP
rs1411353872 270 dbSNP
rs1242669572 278 dbSNP
rs1032126273 283 dbSNP
rs1471857574 287 dbSNP
rs964369596 290 dbSNP
rs1255455651 296 dbSNP
rs974427912 302 dbSNP
rs1028559528 312 dbSNP
rs1188733566 313 dbSNP
rs538719194 314 dbSNP
rs955826739 329 dbSNP
rs1333490615 333 dbSNP
rs1310703754 340 dbSNP
rs1276231227 341 dbSNP
rs145773724 342 dbSNP
rs908706482 352 dbSNP
rs940074336 356 dbSNP
rs974120451 362 dbSNP
rs568747410 363 dbSNP
rs780596691 373 dbSNP
rs112566449 374 dbSNP
rs1409700124 380 dbSNP
rs1298294972 381 dbSNP
rs749987309 389 dbSNP
rs937996173 392 dbSNP
rs1055564892 398 dbSNP
rs896376385 403 dbSNP
rs1335689996 414 dbSNP
rs949346885 415 dbSNP
rs1439670776 423 dbSNP
rs1251293432 428 dbSNP
rs1179089620 430 dbSNP
rs1482367612 432 dbSNP
rs1338127980 437 dbSNP
rs1042186222 438 dbSNP
rs866758477 442 dbSNP
rs1432327517 444 dbSNP
rs1270649963 451 dbSNP
rs1361252477 452 dbSNP
rs1282262013 460 dbSNP
rs902357287 465 dbSNP
rs1316337130 467 dbSNP
rs1307071848 468 dbSNP
rs1392637247 471 dbSNP
rs1376434415 475 dbSNP
rs755557756 479 dbSNP
rs1000737913 483 dbSNP
rs1032073923 489 dbSNP
rs773183589 494 dbSNP
rs1296776130 496 dbSNP
rs190501311 511 dbSNP
rs1453664963 512 dbSNP
rs1364895685 519 dbSNP
rs995811999 521 dbSNP
rs1422171123 522 dbSNP
rs1413287384 525 dbSNP
rs759456760 528 dbSNP
rs1486800502 536 dbSNP
rs575392050 540 dbSNP
rs1259352199 541 dbSNP
rs1214255891 542 dbSNP
rs1485469301 548 dbSNP
rs955610204 549 dbSNP
rs1008903693 551 dbSNP
rs532512204 554 dbSNP
rs767447251 557 dbSNP
rs372940342 558 dbSNP
rs1015881817 559 dbSNP
rs573010232 566 dbSNP
rs974237469 570 dbSNP
rs1382016708 587 dbSNP
rs1386266266 610 dbSNP
rs919998295 613 dbSNP
rs1456888057 624 dbSNP
rs959463955 633 dbSNP
rs533794294 639 dbSNP
rs1476303203 642 dbSNP
rs1421779053 644 dbSNP
rs183106892 651 dbSNP
rs1427735758 666 dbSNP
rs949299758 667 dbSNP
rs1042692125 668 dbSNP
rs1480972175 678 dbSNP
rs760520651 681 dbSNP
rs1271981229 684 dbSNP
rs1213832456 697 dbSNP
rs1175218277 705 dbSNP
rs923875416 706 dbSNP
rs1227093051 710 dbSNP
rs763711644 712 dbSNP
rs1399644093 716 dbSNP
rs1385590826 717 dbSNP
rs1370985697 719 dbSNP
rs1401920449 720 dbSNP
rs1463082485 723 dbSNP
rs1318458155 731 dbSNP
rs936475723 738 dbSNP
rs1053629583 739 dbSNP
rs188585257 746 dbSNP
rs1345832298 755 dbSNP
rs1195142200 762 dbSNP
rs1222702239 764 dbSNP
rs753491520 772 dbSNP
rs1193673405 773 dbSNP
rs1469439573 777 dbSNP
rs1051402444 784 dbSNP
rs890110228 790 dbSNP
rs1339739683 798 dbSNP
rs1225536736 808 dbSNP
rs756884313 810 dbSNP
rs1231550889 820 dbSNP
rs1446516568 835 dbSNP
rs1331188529 841 dbSNP
rs1304848910 843 dbSNP
rs1201662167 846 dbSNP
rs778429066 857 dbSNP
rs1015781198 861 dbSNP
rs1392171458 862 dbSNP
rs1398977430 866 dbSNP
rs193261282 868 dbSNP
rs961635975 869 dbSNP
rs562552758 875 dbSNP
rs995604990 883 dbSNP
rs575949140 895 dbSNP
rs1174166425 901 dbSNP
rs1027130601 902 dbSNP
rs959412037 906 dbSNP
rs1230674832 908 dbSNP
rs1199213278 917 dbSNP
rs369136229 923 dbSNP
rs561629352 926 dbSNP
rs1252239773 927 dbSNP
rs749906359 929 dbSNP
rs1347634799 930 dbSNP
rs918044723 932 dbSNP
rs145440448 933 dbSNP
rs1352238178 935 dbSNP
rs1406531161 936 dbSNP
rs978143719 946 dbSNP
rs1417322781 962 dbSNP
rs1239875731 965 dbSNP
rs546995086 966 dbSNP
rs1332468302 967 dbSNP
rs1414447502 970 dbSNP
rs1366135957 975 dbSNP
rs1374594115 975 dbSNP
rs1405725767 980 dbSNP
rs936588532 980 dbSNP
rs1404084627 982 dbSNP
rs1053577886 985 dbSNP
rs921769766 986 dbSNP
rs1051947791 987 dbSNP
rs1258645691 991 dbSNP
rs1213539363 996 dbSNP
rs1445718930 1007 dbSNP
rs890235609 1015 dbSNP
rs1004943054 1036 dbSNP
rs564966700 1037 dbSNP
rs1291559521 1043 dbSNP
rs780767805 1044 dbSNP
rs1036000728 1049 dbSNP
rs148822362 1053 dbSNP
rs1293623481 1054 dbSNP
rs1416398111 1059 dbSNP
rs995719093 1063 dbSNP
rs1238089205 1067 dbSNP
rs1317582074 1068 dbSNP
rs1294564491 1069 dbSNP
rs868517748 1070 dbSNP
rs1027078443 1074 dbSNP
rs1386450792 1077 dbSNP
rs1162248766 1080 dbSNP
rs1360848641 1084 dbSNP
rs879563514 1086 dbSNP
rs78631727 1087 dbSNP
rs1241948859 1091 dbSNP
rs1217093815 1094 dbSNP
rs1313958227 1099 dbSNP
rs569008810 1103 dbSNP
rs184071023 1115 dbSNP
rs1229772850 1124 dbSNP
rs1275320786 1124 dbSNP
rs1359573261 1126 dbSNP
rs1439928724 1129 dbSNP
rs1269416088 1134 dbSNP
rs978473082 1139 dbSNP
rs550040919 1140 dbSNP
rs1231982879 1146 dbSNP
rs747359831 1163 dbSNP
rs769185474 1165 dbSNP
rs1385752671 1178 dbSNP
rs548043039 1181 dbSNP
rs1161405702 1183 dbSNP
rs1166620212 1191 dbSNP
rs1398281635 1198 dbSNP
rs1187529107 1199 dbSNP
rs367790594 1199 dbSNP
rs375547008 1199 dbSNP
rs3838633 1199 dbSNP
rs397993293 1199 dbSNP
rs398083059 1199 dbSNP
rs749737815 1199 dbSNP
rs772495763 1199 dbSNP
rs796449900 1199 dbSNP
rs989388652 1199 dbSNP
rs1275177114 1202 dbSNP
rs1202651832 1204 dbSNP
rs1307197971 1206 dbSNP
rs1272002324 1207 dbSNP
rs1391791308 1209 dbSNP
rs921883303 1210 dbSNP
rs1301196686 1211 dbSNP
rs566778036 1213 dbSNP
rs1371055525 1214 dbSNP
rs533816385 1215 dbSNP
rs931790318 1218 dbSNP
rs1439556211 1219 dbSNP
rs1171488828 1222 dbSNP
rs1444620445 1237 dbSNP
rs1412032431 1249 dbSNP
rs1393759452 1255 dbSNP
rs187857545 1262 dbSNP
rs554261116 1263 dbSNP
rs940470922 1264 dbSNP
rs781711712 1272 dbSNP
rs1341857776 1274 dbSNP
rs898844407 1275 dbSNP
rs1257001803 1283 dbSNP
rs930348598 1285 dbSNP
rs1277981638 1292 dbSNP
rs1233469191 1303 dbSNP
rs1348576108 1309 dbSNP
rs1456199493 1320 dbSNP
rs1302689627 1322 dbSNP
rs1048628007 1326 dbSNP
rs1372112984 1329 dbSNP
rs1298418319 1347 dbSNP
rs1184898300 1353 dbSNP
rs895426275 1355 dbSNP
rs1312721543 1356 dbSNP
rs1435865186 1380 dbSNP
rs570495479 1382 dbSNP
rs1012798779 1395 dbSNP
rs34117256 1410 dbSNP
rs539851177 1416 dbSNP
rs534831411 1426 dbSNP
rs906570255 1433 dbSNP
rs1474388549 1435 dbSNP
rs999617709 1436 dbSNP
rs1209907604 1447 dbSNP
rs769917805 1457 dbSNP
rs1167153147 1462 dbSNP
rs556340765 1463 dbSNP
rs1212980989 1474 dbSNP
rs1315792801 1484 dbSNP
rs192433106 1504 dbSNP
rs958021623 1505 dbSNP
rs1353237817 1506 dbSNP
rs1292997329 1508 dbSNP
rs1415782970 1510 dbSNP
rs1404928836 1513 dbSNP
rs1287652941 1515 dbSNP
rs1453733259 1520 dbSNP
rs1345828830 1530 dbSNP
rs1161537782 1538 dbSNP
rs1338956399 1548 dbSNP
rs183921714 1551 dbSNP
rs1417421814 1557 dbSNP
rs1186912962 1561 dbSNP
rs554837102 1562 dbSNP
rs1383527957 1563 dbSNP
rs1395554271 1566 dbSNP
rs573364709 1571 dbSNP
rs1184679244 1592 dbSNP
rs568247221 1594 dbSNP
rs1260786203 1604 dbSNP
rs1328755720 1607 dbSNP
rs1332123126 1618 dbSNP
rs1272186114 1655 dbSNP
rs953335537 1659 dbSNP
rs1342611340 1660 dbSNP
rs1228572994 1666 dbSNP
rs1293926758 1680 dbSNP
rs1382146147 1692 dbSNP
rs987688437 1701 dbSNP
rs911733518 1702 dbSNP
rs1278039044 1707 dbSNP
rs1459970685 1710 dbSNP
rs1393963199 1711 dbSNP
rs1316462351 1712 dbSNP
rs1205099194 1715 dbSNP
rs1165901577 1719 dbSNP
rs1459680053 1720 dbSNP
rs1369977626 1738 dbSNP
rs1263408927 1739 dbSNP
rs1427787779 1740 dbSNP
rs1482617444 1743 dbSNP
rs868122724 1751 dbSNP
rs1189888806 1754 dbSNP
rs1466767060 1757 dbSNP
rs554426750 1758 dbSNP
rs971782731 1763 dbSNP
rs779188484 1765 dbSNP
rs1227159993 1772 dbSNP
rs532419555 1782 dbSNP
rs143615905 1786 dbSNP
rs1429114543 1790 dbSNP
rs920387299 1796 dbSNP
rs1421139355 1810 dbSNP
rs1439409007 1811 dbSNP
rs930296391 1813 dbSNP
rs1055399130 1814 dbSNP
rs1178806992 1816 dbSNP
rs1407145821 1817 dbSNP
rs562654110 1818 dbSNP
rs1390659468 1819 dbSNP
rs1170390410 1838 dbSNP
rs1452545479 1842 dbSNP
rs895362386 1845 dbSNP
rs948331585 1848 dbSNP
rs748344490 1850 dbSNP
rs1248017621 1853 dbSNP
rs906692698 1854 dbSNP
rs1277268937 1862 dbSNP
rs577136027 1862 dbSNP
rs548383846 1864 dbSNP
rs1347870301 1865 dbSNP
rs1304176325 1867 dbSNP
rs893924298 1874 dbSNP
rs1010883300 1875 dbSNP
rs566575674 1876 dbSNP
rs1029014157 1879 dbSNP
rs1370905717 1889 dbSNP
rs953379219 1912 dbSNP
rs1008824417 1916 dbSNP
rs1432769845 1921 dbSNP
rs1374779673 1925 dbSNP
rs1311289879 1928 dbSNP
rs1230430498 1941 dbSNP
rs760430645 1943 dbSNP
rs1485914249 1952 dbSNP
rs1361615262 1963 dbSNP
rs1215728935 1965 dbSNP
rs201562934 1972 dbSNP
rs7664981 1973 dbSNP
rs1199947371 1975 dbSNP
rs1426099344 1976 dbSNP
rs776305204 1979 dbSNP
rs1432889688 1980 dbSNP
rs971897529 1980 dbSNP
rs1174028075 1987 dbSNP
rs1365551810 1989 dbSNP
rs920313785 1995 dbSNP
rs1348599462 1997 dbSNP
rs1279076955 2000 dbSNP
rs1298071654 2009 dbSNP
rs1240021651 2013 dbSNP
rs1359238440 2021 dbSNP
rs1289912565 2029 dbSNP
rs951814670 2036 dbSNP
rs991521247 2038 dbSNP
rs1334717534 2052 dbSNP
rs778924528 2054 dbSNP
rs1382136144 2061 dbSNP
rs761463559 2061 dbSNP
rs1157549581 2062 dbSNP
rs949787889 2065 dbSNP
rs1046638967 2066 dbSNP
rs1175927522 2067 dbSNP
rs928229176 2067 dbSNP
rs935473343 2067 dbSNP
rs1366448234 2074 dbSNP
rs1384653391 2076 dbSNP
rs1445839526 2079 dbSNP
rs1283632579 2081 dbSNP
rs1052617621 2084 dbSNP
rs1330079110 2090 dbSNP
rs1331439902 2092 dbSNP
rs552544590 2093 dbSNP
rs34966191 2101 dbSNP
rs1232954482 2103 dbSNP
rs1378136026 2105 dbSNP
rs1308707034 2107 dbSNP
rs1284637201 2111 dbSNP
rs1316949057 2116 dbSNP
rs1450117535 2126 dbSNP
rs188617807 2127 dbSNP
rs1238825107 2130 dbSNP
rs1316930946 2132 dbSNP
rs1435221640 2144 dbSNP
rs1390321414 2150 dbSNP
rs1283773710 2156 dbSNP
rs1361557556 2160 dbSNP
rs1460632596 2167 dbSNP
rs1010999291 2186 dbSNP
rs1165421381 2191 dbSNP
rs570755226 2192 dbSNP
rs1242079999 2193 dbSNP
rs1189243747 2195 dbSNP
rs1466292643 2198 dbSNP
rs1050824302 2209 dbSNP
rs112417854 2212 dbSNP
rs561253666 2214 dbSNP
rs764869774 2222 dbSNP
rs1009355084 2228 dbSNP
rs1018847024 2234 dbSNP
rs1337318291 2247 dbSNP
rs1440370711 2252 dbSNP
rs961947075 2259 dbSNP
rs1366699827 2261 dbSNP
rs993265807 2262 dbSNP
rs773279848 2264 dbSNP
rs1350121978 2272 dbSNP
rs556153674 2278 dbSNP
rs568163420 2286 dbSNP
rs1378996516 2290 dbSNP
rs535224677 2293 dbSNP
rs1169750678 2297 dbSNP
rs1451953567 2299 dbSNP
rs1166122359 2307 dbSNP
rs991244427 2321 dbSNP
rs1456745023 2330 dbSNP
rs1299480410 2331 dbSNP
rs1248702161 2333 dbSNP
rs1223428575 2371 dbSNP
rs553815343 2372 dbSNP
rs1273693908 2375 dbSNP
rs1445367231 2382 dbSNP
rs915684315 2393 dbSNP
rs573400011 2394 dbSNP
rs981542894 2395 dbSNP
rs1218133274 2406 dbSNP
rs1276228775 2410 dbSNP
rs1367808946 2410 dbSNP
rs928172529 2411 dbSNP
rs562775507 2426 dbSNP
rs1370335002 2428 dbSNP
rs1384893088 2428 dbSNP
rs1246552785 2436 dbSNP
rs1309084115 2447 dbSNP
rs1374181806 2449 dbSNP
rs935588023 2455 dbSNP
rs1319649826 2456 dbSNP
rs1206422288 2458 dbSNP
rs1052566834 2464 dbSNP
rs537340284 2466 dbSNP
rs540425380 2474 dbSNP
rs558829093 2489 dbSNP
rs946903699 2503 dbSNP
rs1469876444 2505 dbSNP
rs1458434464 2506 dbSNP
rs1178082530 2508 dbSNP
rs62309453 2509 dbSNP
rs1483956595 2510 dbSNP
rs889225673 2515 dbSNP
rs1182913328 2520 dbSNP
rs1312230999 2531 dbSNP
rs1280210383 2533 dbSNP
rs1413736593 2545 dbSNP
rs1408803557 2546 dbSNP
rs1349512179 2549 dbSNP
rs758034258 2553 dbSNP
rs1040793511 2564 dbSNP
rs1412105588 2572 dbSNP
rs1354055657 2576 dbSNP
rs897706170 2578 dbSNP
rs993382036 2582 dbSNP
rs766965430 2588 dbSNP
rs1027561458 2589 dbSNP
rs1157084047 2590 dbSNP
rs1456856527 2595 dbSNP
rs1400571839 2603 dbSNP
rs1412980585 2604 dbSNP
rs1182581753 2609 dbSNP
rs1473437805 2617 dbSNP
rs1464832141 2628 dbSNP
rs1328889963 2631 dbSNP
rs887608470 2632 dbSNP
rs1013187949 2635 dbSNP
rs1213045956 2640 dbSNP
rs1022699336 2641 dbSNP
rs971567581 2643 dbSNP
rs1229899514 2644 dbSNP
rs981107933 2647 dbSNP
rs1312541319 2669 dbSNP
rs1397105566 2675 dbSNP
rs1381983121 2676 dbSNP
rs1031345372 2677 dbSNP
rs1434501978 2679 dbSNP
rs1283503610 2680 dbSNP
rs956909054 2684 dbSNP
rs1460134133 2689 dbSNP
rs1184211471 2690 dbSNP
rs1288479429 2690 dbSNP
rs796700410 2690 dbSNP
rs544217126 2691 dbSNP
rs548709217 2693 dbSNP
rs1248146523 2702 dbSNP
rs376049170 2702 dbSNP
rs946889658 2702 dbSNP
rs1317080340 2703 dbSNP
rs1466903503 2705 dbSNP
rs1198169020 2711 dbSNP
rs1256428431 2714 dbSNP
rs1323987410 2716 dbSNP
rs1294090061 2722 dbSNP
rs1228363916 2727 dbSNP
rs1366019220 2731 dbSNP
rs1322714311 2736 dbSNP
rs1438908645 2740 dbSNP
rs562517969 2741 dbSNP
rs1292695305 2752 dbSNP
rs1458243915 2758 dbSNP
rs530080311 2764 dbSNP
rs541989689 2765 dbSNP
rs1448855851 2767 dbSNP
rs771121669 2772 dbSNP
rs1237383736 2778 dbSNP
rs944787612 2784 dbSNP
rs1040316168 2787 dbSNP
rs15619 2790 dbSNP
rs1266269467 2799 dbSNP
rs1449447645 2799 dbSNP
rs184354519 2804 dbSNP
rs1489658389 2812 dbSNP
rs142576119 2822 dbSNP
rs1424716287 2823 dbSNP
rs527538401 2828 dbSNP
rs1299833108 2830 dbSNP
rs1168045532 2835 dbSNP
rs1330696605 2839 dbSNP
rs1048947520 2852 dbSNP
rs116062786 2853 dbSNP
rs1392605812 2865 dbSNP
rs1012723565 2868 dbSNP
rs1428962053 2874 dbSNP
rs1371090687 2876 dbSNP
rs1169893250 2879 dbSNP
rs564380175 2880 dbSNP
rs1414511982 2886 dbSNP
rs144746941 2888 dbSNP
rs1199127559 2898 dbSNP
rs1434604419 2902 dbSNP
rs1249995289 2911 dbSNP
rs1181917378 2916 dbSNP
rs3177441 2919 dbSNP
rs906912572 2921 dbSNP
rs550077865 2922 dbSNP
rs1209421756 2923 dbSNP
rs1432736177 2933 dbSNP
rs1298733738 2934 dbSNP
rs1339551582 2937 dbSNP
rs567998579 2943 dbSNP
rs190144165 2954 dbSNP
rs1235673693 2956 dbSNP
rs1031460127 2957 dbSNP
rs1286150351 2972 dbSNP
rs955690355 2975 dbSNP
rs1350980059 2980 dbSNP
rs527642230 2981 dbSNP
rs1276522862 2983 dbSNP
rs989839832 2985 dbSNP
rs1325977387 2994 dbSNP
rs1219886365 2995 dbSNP
rs1278079414 2997 dbSNP
rs1440786355 2999 dbSNP
rs1218477389 3000 dbSNP
rs1467200230 3010 dbSNP
rs1312690448 3019 dbSNP
rs1181847841 3022 dbSNP
rs1409348895 3022 dbSNP
rs1473108828 3023 dbSNP
rs1186037657 3025 dbSNP
rs1254464887 3025 dbSNP
rs547223839 3033 dbSNP
rs1264570603 3037 dbSNP
rs772223705 3044 dbSNP
rs762918190 3054 dbSNP
rs1192002331 3070 dbSNP
rs565724017 3081 dbSNP
rs968721715 3097 dbSNP
rs1488047095 3101 dbSNP
rs552617257 3114 dbSNP
rs571534768 3124 dbSNP
rs1339808514 3128 dbSNP
rs910725770 3138 dbSNP
rs1397289959 3140 dbSNP
rs944923391 3142 dbSNP
rs1157912037 3147 dbSNP
rs976120811 3165 dbSNP
rs2291474 3167 dbSNP
rs1161846199 3176 dbSNP
rs1472720123 3179 dbSNP
rs1369583891 3182 dbSNP
rs1189651832 3188 dbSNP
rs1159123817 3194 dbSNP
rs17655832 3197 dbSNP
rs1397881643 3216 dbSNP
rs1304802206 3221 dbSNP
rs1333038291 3222 dbSNP
rs1049059287 3223 dbSNP
rs1274492313 3224 dbSNP
rs1286002779 3237 dbSNP
rs1226428048 3241 dbSNP
rs1342911101 3242 dbSNP
rs1225561528 3243 dbSNP
rs138323021 3249 dbSNP
rs1353703972 3253 dbSNP
rs1214885438 3254 dbSNP
rs1248127787 3257 dbSNP
rs1271421221 3262 dbSNP
rs756354911 3263 dbSNP
rs1452551832 3266 dbSNP
rs1482881165 3267 dbSNP
rs1197667339 3269 dbSNP
rs1435296985 3271 dbSNP
rs948663944 3275 dbSNP
rs1321945635 3280 dbSNP
rs182377063 3282 dbSNP
rs77447731 3287 dbSNP
rs1244640894 3291 dbSNP
rs1044208078 3297 dbSNP
rs556799103 3298 dbSNP
rs1448274276 3304 dbSNP
rs1389570986 3305 dbSNP
rs1189298834 3318 dbSNP
rs574779245 3320 dbSNP
rs1470868578 3324 dbSNP
rs907016734 3325 dbSNP
rs542202920 3338 dbSNP
rs185655709 3348 dbSNP
rs572531026 3349 dbSNP
rs891583919 3361 dbSNP
rs78369157 3366 dbSNP
rs189383236 3367 dbSNP
rs1363578915 3368 dbSNP
rs1272696529 3371 dbSNP
rs1435363436 3373 dbSNP
rs564245621 3376 dbSNP
rs1008214408 3378 dbSNP
rs1017880843 3381 dbSNP
rs1404584244 3387 dbSNP
rs1323087724 3392 dbSNP
rs531519032 3394 dbSNP
rs1329606777 3401 dbSNP
rs569076567 3405 dbSNP
rs1206078366 3406 dbSNP
rs1190822631 3409 dbSNP
rs377673369 3410 dbSNP
rs1478510610 3417 dbSNP
rs1247006818 3418 dbSNP
rs976256441 3423 dbSNP
rs919309757 3425 dbSNP
rs1310150279 3428 dbSNP
rs1205847085 3431 dbSNP
rs550140437 3446 dbSNP
rs1275975704 3459 dbSNP
rs1218263346 3461 dbSNP
rs1367871377 3473 dbSNP
rs1285537990 3481 dbSNP
rs1238521442 3495 dbSNP
rs180929445 3498 dbSNP
rs1350305046 3500 dbSNP
rs1267786551 3501 dbSNP
rs1357432524 3503 dbSNP
rs771038170 3507 dbSNP
rs767248224 3509 dbSNP
rs1464036155 3513 dbSNP
rs1357484748 3516 dbSNP
rs112197563 3529 dbSNP
rs1175463072 3529 dbSNP
rs78085384 3536 dbSNP
rs1439267339 3538 dbSNP
rs1489860875 3539 dbSNP
rs1027875374 3542 dbSNP
rs1178269064 3546 dbSNP
rs1250855804 3550 dbSNP
rs1471476826 3550 dbSNP
rs1182808447 3556 dbSNP
rs1198715469 3562 dbSNP
rs1481610056 3581 dbSNP
rs1235183419 3593 dbSNP
rs185590853 3598 dbSNP
rs1437283619 3606 dbSNP
rs1185304877 3607 dbSNP
rs1226231365 3619 dbSNP
rs1044685455 3624 dbSNP
rs1055720 3626 dbSNP
rs551043287 3628 dbSNP
rs1472331286 3630 dbSNP
rs938486415 3632 dbSNP
rs891508973 3650 dbSNP
rs1318752567 3652 dbSNP
rs1011346617 3658 dbSNP
rs570742528 3662 dbSNP
rs1159582032 3671 dbSNP
rs1420763003 3676 dbSNP
rs1411564163 3677 dbSNP
rs1181256603 3678 dbSNP
rs1055721 3680 dbSNP
rs1006598447 3682 dbSNP
rs776481509 3684 dbSNP
rs1464168110 3689 dbSNP
rs556628744 3703 dbSNP
rs370383127 3707 dbSNP
rs1269089548 3716 dbSNP
rs1241669628 3718 dbSNP
rs1018266588 3719 dbSNP
rs1229437712 3732 dbSNP
rs966328605 3741 dbSNP
rs1435420843 3742 dbSNP
rs1385082049 3744 dbSNP
rs1295572223 3747 dbSNP
rs1315405854 3750 dbSNP
rs1434572048 3770 dbSNP
rs1341637158 3772 dbSNP
rs1244517026 3781 dbSNP
rs997601421 3783 dbSNP
rs374390364 3784 dbSNP
rs1320464038 3789 dbSNP
rs1347941989 3796 dbSNP
rs1163982998 3798 dbSNP
rs1445223157 3816 dbSNP
rs1026459206 3820 dbSNP
rs1186122095 3826 dbSNP
rs950773795 3828 dbSNP
rs984827058 3831 dbSNP
rs371865042 3835 dbSNP
rs1257067625 3838 dbSNP
rs909321889 3844 dbSNP
rs970460027 3846 dbSNP
rs980159552 3847 dbSNP
rs1256771717 3850 dbSNP
rs928506272 3851 dbSNP
rs938580283 3856 dbSNP
rs532110017 3858 dbSNP
rs1297955135 3863 dbSNP
rs535489598 3864 dbSNP
rs988616523 3870 dbSNP
rs554100833 3883 dbSNP
rs879404694 3890 dbSNP
rs1292741583 3891 dbSNP
rs1365205916 3891 dbSNP
rs913059046 3891 dbSNP
rs533748155 3895 dbSNP
rs572592523 3897 dbSNP
rs114495443 3898 dbSNP
rs1428516408 3898 dbSNP
rs1373192266 3899 dbSNP
rs1194877170 3900 dbSNP
rs1431153122 3900 dbSNP
rs1267042648 3902 dbSNP
rs1389917179 3910 dbSNP
rs1200606882 3913 dbSNP
rs1490972762 3914 dbSNP
rs1273078412 3916 dbSNP
rs1423239166 3917 dbSNP
rs1464099425 3922 dbSNP
rs1342956279 3930 dbSNP
rs548557792 3930 dbSNP
rs367612802 3933 dbSNP
rs1311830063 3940 dbSNP
rs1300282706 3945 dbSNP
rs1405350354 3952 dbSNP
rs889579422 3968 dbSNP
rs1304734844 3976 dbSNP
rs190253563 3997 dbSNP
rs543557551 3999 dbSNP
rs75038306 4008 dbSNP
rs181463903 4009 dbSNP
rs1376747515 4016 dbSNP
rs1176770831 4027 dbSNP
rs529154335 4029 dbSNP
rs997736694 4030 dbSNP
rs1219659194 4032 dbSNP
rs1438909714 4042 dbSNP
rs1252672857 4045 dbSNP
rs1026552429 4046 dbSNP
rs1344517693 4052 dbSNP
rs1256791700 4053 dbSNP
rs1225628677 4055 dbSNP
rs1277155668 4058 dbSNP
rs1286293520 4059 dbSNP
rs186937013 4060 dbSNP
rs191778089 4069 dbSNP
rs1336975323 4070 dbSNP
rs1400918130 4070 dbSNP
rs549721524 4070 dbSNP
rs1234764109 4082 dbSNP
rs1256012165 4083 dbSNP
rs1343679185 4084 dbSNP
rs1006427308 4087 dbSNP
rs1366078379 4087 dbSNP
rs1186105261 4091 dbSNP
rs1198620462 4096 dbSNP
rs1265271287 4097 dbSNP
rs1016752220 4102 dbSNP
rs1488480416 4109 dbSNP
rs1463726722 4110 dbSNP
rs1265937846 4113 dbSNP
rs1204365449 4117 dbSNP
rs970173161 4118 dbSNP
rs980469788 4124 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 57606.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000264313.6 | 3UTR | AAAAAAAUCUAUGCACUUAACCUACAAAAUCUCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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