pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SHCBP1   
Synonyms PAL
Description SHC binding and spindle associated 1
Transcript NM_024745   
Expression
Putative miRNA Targets on SHCBP1
3'UTR of SHCBP1
(miRNA target sites are highlighted)
>SHCBP1|NM_024745|3'UTR
   1 CTACAGTGATGTAAGTAGATAGCAAAATACTGGATTTTGCACATGCTGCCCTAAGAATCACTGCTGCCATTGTAGTTTGC
  81 TGTATTGTCTGTATTTTATATTTGATTATTTGGGCTTGAGTGAAAGGTAGATTTATTTCCATTTGCAGGTGTTGCACATA
 161 AAACACTCCCTCTTTATAAGAAAAATCATAAATGCATATAAAATAGAAAATATTTGGAGATTGCTTATCTGAAAGTCTTG
 241 CTTTCTTATACACATGGTTCTCTCATATTAAGCCTGGTAGTAACTTTTTAGTGTAATTACCTTTAGCACTTCAAAGACGA
 321 GGAAGTAAGGAAGGGAATGCAAGACTAGTGCATAAAAATGCAATAGGTGTCATATGTACAGCATTCTTCTTAGAGTTGCC
 401 TTTTCATCCCAATTACAGTGAGTCTGATTTCCATCCTGTATTTGCATAATACTTGTCTTAAAATAAAAGCTTTTATGATT
 481 GGGAATTTATCTGCCTAATCAGACTTATTATTGAGACGTCAATGGGACGCATTTTTCTGTTGAGCTATGCAGTCGTCAAA
 561 ACAGCGATAGACAGCATAGGAGGTTTGAAGCAGAAATGAAATGTGTTATTCAGAGCCAATGTTGTACATAGAGCATTTTC
 641 ACTATTGCTGAATGGGAATGATTAAAAACAAGGTATTTTTCGGGCCAGGCGGTGGCTCACGCTTGTAATCGCAGCACTTT
 721 GGGAGGCTGAGGCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACTAGCCTAGGCAACATAGTGAGACCCTGTCTCTACT
 801 AAAAATAAATTTAAAAAAAATTAGCTGAGTGTGGTGGTGCATGCATGTAGTTCCAGCTACTCAGGAGGCTGAGGCTAGAG
 881 GATCCTTGAGCCCAGGAGGTTGAGGCTGCAGTGAGGTGTGATTGCGCCACTGCATTCCAGCTTGGGCGACAGAGCGAGAC
 961 CCAGTCTCAAAAAAAAAAAAAAGTATTTTTCTCTTACCGTTACAGTATTCTGATTATATTACTGACACAGTCAAAATGAT
1041 TAACTGTACAACCTGTATCTGCTGGGTGTTCTTGTTATCATATTGTAAAACAGCTTTAAAAATATTTATATTTTAAAAAC
1121 TGTATGTGACATTAATATGCCTAATGATTAAAATTATAGTGATGAAATAACAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaucGGA-GGUA----CUUAAGACUAc 5'
              |:| ||:|    | |||||||| 
Target 5' ttctCTTACCGTTACAGTATTCTGATt 3'
989 - 1015 152.00 -11.20
2
miRNA  3' gaucgGAGGUACUUAAGACUAc 5'
               :| ||  :| |||||| 
Target 5' cccaaTTACAGTGAGTCTGATt 3'
408 - 429 121.00 -8.50
3
miRNA  3' gaUC-GGAGGUACUU--------AAGACUAc 5'
            || | || |||::        ||||| | 
Target 5' tgAGACGTCAATGGGACGCATTTTTCTGTTg 3'
512 - 542 114.00 -11.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31597878 6 COSMIC
COSN30517558 55 COSMIC
COSN31480087 67 COSMIC
COSN30193794 79 COSMIC
COSN30166932 104 COSMIC
COSN30542775 108 COSMIC
COSN30543139 112 COSMIC
COSN31598546 126 COSMIC
COSN31503497 158 COSMIC
COSN28201561 240 COSMIC
COSN16115317 510 COSMIC
COSN30173688 529 COSMIC
COSN22428663 1082 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1027147652 3 dbSNP
rs747664677 4 dbSNP
rs1014333552 10 dbSNP
rs1389109997 11 dbSNP
rs1259304000 13 dbSNP
rs780821668 16 dbSNP
rs1403232551 19 dbSNP
rs754573344 20 dbSNP
rs751269845 24 dbSNP
rs1261277306 25 dbSNP
rs1349926035 28 dbSNP
rs1216580233 33 dbSNP
rs376151935 39 dbSNP
rs1275785829 41 dbSNP
rs758217756 43 dbSNP
rs750309078 45 dbSNP
rs1219181826 48 dbSNP
rs1279848469 49 dbSNP
rs537691499 51 dbSNP
rs1418884156 62 dbSNP
rs894693312 73 dbSNP
rs1000370858 80 dbSNP
rs766447578 81 dbSNP
rs1035665230 91 dbSNP
rs1214478817 93 dbSNP
rs184151080 98 dbSNP
rs1041836886 99 dbSNP
rs1478396546 100 dbSNP
rs1196543748 104 dbSNP
rs903171593 108 dbSNP
rs1472698848 121 dbSNP
rs1010354538 126 dbSNP
rs576185626 140 dbSNP
rs1414013321 149 dbSNP
rs1426180793 160 dbSNP
rs754658843 163 dbSNP
rs1042220885 166 dbSNP
rs1051806820 170 dbSNP
rs1470826631 173 dbSNP
rs1252903719 175 dbSNP
rs931968871 180 dbSNP
rs1284587136 185 dbSNP
rs1053585399 199 dbSNP
rs932563401 202 dbSNP
rs1285381425 214 dbSNP
rs1212592865 219 dbSNP
rs1219396559 230 dbSNP
rs746476202 231 dbSNP
rs1466696525 237 dbSNP
rs921201050 239 dbSNP
rs1039989476 242 dbSNP
rs1188612430 252 dbSNP
rs976434222 262 dbSNP
rs555441476 265 dbSNP
rs1379124980 267 dbSNP
rs1054722 279 dbSNP
rs192275794 282 dbSNP
rs1281953435 288 dbSNP
rs1334489915 290 dbSNP
rs1384808387 291 dbSNP
rs951173186 302 dbSNP
rs982973575 310 dbSNP
rs1354725444 312 dbSNP
rs1225248983 318 dbSNP
rs916988256 319 dbSNP
rs554060338 324 dbSNP
rs952494015 326 dbSNP
rs992514301 327 dbSNP
rs187997816 344 dbSNP
rs1344839744 349 dbSNP
rs548497843 351 dbSNP
rs1258683323 365 dbSNP
rs1456758423 367 dbSNP
rs1176366224 372 dbSNP
rs991640619 373 dbSNP
rs1439947364 375 dbSNP
rs1034625456 378 dbSNP
rs1375433847 383 dbSNP
rs7185553 386 dbSNP
rs1465481156 391 dbSNP
rs1173140129 392 dbSNP
rs1438821526 393 dbSNP
rs1407987770 396 dbSNP
rs1463829445 403 dbSNP
rs139628455 405 dbSNP
rs7185538 424 dbSNP
rs1393362727 425 dbSNP
rs754339226 426 dbSNP
rs968947845 433 dbSNP
rs538323876 436 dbSNP
rs571000979 437 dbSNP
rs764721594 438 dbSNP
rs1234581598 440 dbSNP
rs1265587186 446 dbSNP
rs1003064544 451 dbSNP
rs1453367622 452 dbSNP
rs1343631975 463 dbSNP
rs1010408724 475 dbSNP
rs1259128797 477 dbSNP
rs1457882822 478 dbSNP
rs1178647193 479 dbSNP
rs1264637926 481 dbSNP
rs1161805604 483 dbSNP
rs1401644145 493 dbSNP
rs1431285129 494 dbSNP
rs1395009469 508 dbSNP
rs183780120 517 dbSNP
rs756402623 518 dbSNP
rs1463706031 523 dbSNP
rs1292048682 524 dbSNP
rs753136105 528 dbSNP
rs868021999 529 dbSNP
rs879020151 541 dbSNP
rs1387389270 542 dbSNP
rs11863327 545 dbSNP
rs1054042341 546 dbSNP
rs996659795 547 dbSNP
rs899650679 554 dbSNP
rs1041013809 555 dbSNP
rs1309692612 564 dbSNP
rs150998534 565 dbSNP
rs1263274212 566 dbSNP
rs943929947 568 dbSNP
rs548441725 574 dbSNP
rs1217684548 575 dbSNP
rs941297108 576 dbSNP
rs1270415022 578 dbSNP
rs888359747 583 dbSNP
rs1301319304 593 dbSNP
rs142690638 602 dbSNP
rs1192924387 608 dbSNP
rs1424040549 609 dbSNP
rs1279551096 613 dbSNP
rs1231940431 618 dbSNP
rs192377280 619 dbSNP
rs931066560 628 dbSNP
rs929776128 644 dbSNP
rs565347775 646 dbSNP
rs1368068470 648 dbSNP
rs916999709 656 dbSNP
rs991178539 660 dbSNP
rs1360214117 668 dbSNP
rs1358776281 672 dbSNP
rs1399918440 673 dbSNP
rs71378096 676 dbSNP
rs774503659 681 dbSNP
rs937036870 682 dbSNP
rs926980588 690 dbSNP
rs978433613 691 dbSNP
rs981698006 700 dbSNP
rs766557924 701 dbSNP
rs796681776 710 dbSNP
rs968998806 711 dbSNP
rs967562530 723 dbSNP
rs1215763749 724 dbSNP
rs1366081447 740 dbSNP
rs763179186 747 dbSNP
rs1427339523 755 dbSNP
rs1259250698 756 dbSNP
rs1187859640 760 dbSNP
rs988988271 762 dbSNP
rs1255225449 783 dbSNP
rs1424612496 784 dbSNP
rs1165771094 787 dbSNP
rs1011547872 788 dbSNP
rs1159351610 789 dbSNP
rs1256589502 794 dbSNP
rs1347402757 800 dbSNP
rs1208433058 811 dbSNP
rs957704736 812 dbSNP
rs954822791 813 dbSNP
rs1380418515 820 dbSNP
rs996250758 821 dbSNP
rs1305777064 830 dbSNP
rs899702986 831 dbSNP
rs1030436755 834 dbSNP
rs1215341754 847 dbSNP
rs1238735558 855 dbSNP
rs1040898772 857 dbSNP
rs1318587523 879 dbSNP
rs774832784 880 dbSNP
rs773003789 890 dbSNP
rs996692073 894 dbSNP
rs1008153015 895 dbSNP
rs886998962 898 dbSNP
rs1461641813 900 dbSNP
rs900563666 914 dbSNP
rs1185621943 924 dbSNP
rs543186218 925 dbSNP
rs1439331882 926 dbSNP
rs1177785354 946 dbSNP
rs534219469 947 dbSNP
rs888369837 948 dbSNP
rs1417010152 955 dbSNP
rs1376600729 956 dbSNP
rs1471135562 962 dbSNP
rs931015097 966 dbSNP
rs1461064012 967 dbSNP
rs1370803562 968 dbSNP
rs1171863299 974 dbSNP
rs1477970994 979 dbSNP
rs1445589984 983 dbSNP
rs770519938 983 dbSNP
rs1046924427 984 dbSNP
rs1217388239 985 dbSNP
rs568268549 998 dbSNP
rs747859808 999 dbSNP
rs1205267112 1008 dbSNP
rs1476024930 1018 dbSNP
rs1256791264 1022 dbSNP
rs1457480693 1027 dbSNP
rs1205557030 1035 dbSNP
rs1234648935 1043 dbSNP
rs12928618 1046 dbSNP
rs866652634 1049 dbSNP
rs937088199 1051 dbSNP
rs1253198620 1061 dbSNP
rs928809281 1062 dbSNP
rs1481715831 1077 dbSNP
rs927062221 1082 dbSNP
rs1199338783 1092 dbSNP
rs1400115938 1093 dbSNP
rs981540860 1106 dbSNP
rs1334527967 1115 dbSNP
rs1355742972 1120 dbSNP
rs1433626871 1120 dbSNP
rs1273745858 1125 dbSNP
rs1345997867 1139 dbSNP
rs768241041 1159 dbSNP
rs968047415 1162 dbSNP
rs114722965 1163 dbSNP
rs1215349691 1168 dbSNP
rs1275324610 1176 dbSNP
rs1235546308 1192 dbSNP
rs1220858845 1199 dbSNP
rs913492006 1201 dbSNP
rs1490983356 1203 dbSNP
rs1192201576 1206 dbSNP
rs989040769 1209 dbSNP
rs954926654 1214 dbSNP
rs1170039555 1217 dbSNP
rs1306954792 1219 dbSNP
rs1403248594 1225 dbSNP
rs957423232 1226 dbSNP
rs923455738 1237 dbSNP
rs187394389 1239 dbSNP
rs974934541 1252 dbSNP
rs965189448 1260 dbSNP
rs1432191407 1265 dbSNP
rs1339790328 1267 dbSNP
rs1299439706 1268 dbSNP
rs1227823736 1275 dbSNP
rs542125888 1286 dbSNP
rs1354433109 1291 dbSNP
rs746670340 1325 dbSNP
rs966081587 1335 dbSNP
rs375868096 1339 dbSNP
rs1361745107 1349 dbSNP
rs1006179743 1353 dbSNP
rs1393283590 1360 dbSNP
rs950695943 1368 dbSNP
rs1263050756 1374 dbSNP
rs1448103438 1375 dbSNP
rs1025529789 1377 dbSNP
rs994074216 1392 dbSNP
rs1471596971 1402 dbSNP
rs1008038506 1408 dbSNP
rs574777135 1409 dbSNP
rs1476075916 1412 dbSNP
rs1425960248 1424 dbSNP
rs1156324197 1428 dbSNP
rs886921026 1450 dbSNP
rs895715391 1459 dbSNP
rs1025587793 1461 dbSNP
rs1057395785 1465 dbSNP
rs1417308387 1476 dbSNP
rs1338546717 1485 dbSNP
rs1452167090 1495 dbSNP
rs1316046397 1499 dbSNP
rs1385305584 1500 dbSNP
rs1237990041 1502 dbSNP
rs1285415077 1505 dbSNP
rs1352025673 1509 dbSNP
rs1001368755 1520 dbSNP
rs556515195 1524 dbSNP
rs199591996 1525 dbSNP
rs898198090 1532 dbSNP
rs1055347375 1533 dbSNP
rs1446091384 1536 dbSNP
rs937099512 1544 dbSNP
rs1271530603 1552 dbSNP
rs1160281118 1555 dbSNP
rs1399757880 1557 dbSNP
rs1042789812 1564 dbSNP
rs779748792 1566 dbSNP
rs537561610 1574 dbSNP
rs1045893350 1576 dbSNP
rs558338612 1586 dbSNP
rs776082520 1586 dbSNP
rs912875031 1586 dbSNP
rs1241763950 1587 dbSNP
rs979885360 1588 dbSNP
rs1204641185 1605 dbSNP
rs1265386297 1605 dbSNP
rs1273540703 1605 dbSNP
rs1462376768 1612 dbSNP
rs1260554025 1616 dbSNP
rs1237316672 1618 dbSNP
rs1419197443 1621 dbSNP
rs1183397894 1634 dbSNP
rs963199094 1637 dbSNP
rs538003884 1653 dbSNP
rs577272366 1655 dbSNP
rs1310549573 1658 dbSNP
rs1480078212 1660 dbSNP
rs1176806097 1663 dbSNP
rs565032116 1664 dbSNP
rs148725754 1668 dbSNP
rs1297859920 1672 dbSNP
rs1323514648 1681 dbSNP
rs974709290 1687 dbSNP
rs966133271 1689 dbSNP
rs923537984 1696 dbSNP
rs1345357013 1703 dbSNP
rs745423179 1707 dbSNP
rs1285570788 1708 dbSNP
rs534141539 1711 dbSNP
rs1224755617 1713 dbSNP
rs964867370 1714 dbSNP
rs1019019093 1715 dbSNP
rs1196974739 1723 dbSNP
rs1390990000 1726 dbSNP
rs566697473 1735 dbSNP
rs1490161979 1736 dbSNP
rs1200118346 1741 dbSNP
rs183058565 1743 dbSNP
rs983927104 1748 dbSNP
rs909306502 1753 dbSNP
rs1451279764 1757 dbSNP
rs1373798318 1763 dbSNP
rs1025894539 1764 dbSNP
rs951278409 1764 dbSNP
rs984811801 1769 dbSNP
rs950790069 1781 dbSNP
rs1365103334 1782 dbSNP
rs1305536043 1791 dbSNP
rs995436652 1791 dbSNP
rs1339139186 1795 dbSNP
rs1453905518 1796 dbSNP
rs898372472 1800 dbSNP
rs1251261855 1801 dbSNP
rs866004289 1805 dbSNP
rs1195560371 1811 dbSNP
rs1452465484 1814 dbSNP
rs1261288477 1816 dbSNP
rs879725669 1818 dbSNP
rs576425960 1821 dbSNP
rs1287389040 1844 dbSNP
rs1358155048 1852 dbSNP
rs1026296932 1853 dbSNP
rs1013538440 1856 dbSNP
rs1234146485 1862 dbSNP
rs536531550 1864 dbSNP
rs1270897038 1874 dbSNP
rs1035579914 1876 dbSNP
rs1484858677 1877 dbSNP
rs778101389 1906 dbSNP
rs1001778950 1927 dbSNP
rs568004568 1928 dbSNP
rs1163011065 1931 dbSNP
rs1045486151 1932 dbSNP
rs1042844155 1937 dbSNP
rs945780069 1943 dbSNP
rs892004451 1951 dbSNP
rs1054993251 1952 dbSNP
rs1331336835 1958 dbSNP
rs1317131345 1965 dbSNP
rs1289813035 1969 dbSNP
rs1330719995 1973 dbSNP
rs1011352971 1978 dbSNP
rs1362176076 1982 dbSNP
rs891546523 1988 dbSNP
rs1052802914 1992 dbSNP
rs932966944 1996 dbSNP
rs1381613610 2005 dbSNP
rs1245995125 2007 dbSNP
rs902094827 2012 dbSNP
rs1158994745 2032 dbSNP
rs1315049716 2037 dbSNP
rs1215051281 2038 dbSNP
rs1281664170 2048 dbSNP
rs756664450 2052 dbSNP
rs943545225 2057 dbSNP
rs1393182513 2059 dbSNP
rs1175676530 2060 dbSNP
rs1478358338 2064 dbSNP
rs531158989 2065 dbSNP
rs944715273 2072 dbSNP
rs984905709 2073 dbSNP
rs1242712053 2082 dbSNP
rs1372734106 2084 dbSNP
rs1445484625 2084 dbSNP
rs1191235607 2085 dbSNP
rs911886315 2087 dbSNP
rs1449124397 2098 dbSNP
rs147239153 2100 dbSNP
rs1210585692 2101 dbSNP
rs769486073 2102 dbSNP
rs143924159 2108 dbSNP
rs1283011830 2109 dbSNP
rs1336500906 2112 dbSNP
rs1220470482 2118 dbSNP
rs918434028 2119 dbSNP
rs992128309 2126 dbSNP
rs1452997711 2127 dbSNP
rs527501804 2137 dbSNP
rs960701832 2142 dbSNP
rs1036036486 2144 dbSNP
rs1318686197 2145 dbSNP
rs980017099 2150 dbSNP
rs1201478322 2151 dbSNP
rs1034248788 2164 dbSNP
rs970368629 2167 dbSNP
rs1021504616 2177 dbSNP
rs1461938872 2180 dbSNP
rs60938441 2190 dbSNP
rs1205879970 2191 dbSNP
rs1231215320 2192 dbSNP
rs1469655183 2200 dbSNP
rs1177875979 2210 dbSNP
rs1341966735 2217 dbSNP
rs542187296 2218 dbSNP
rs1410723542 2235 dbSNP
rs1479743182 2238 dbSNP
rs1001377741 2242 dbSNP
rs891557764 2247 dbSNP
rs1338344938 2248 dbSNP
rs1352436454 2257 dbSNP
rs1413935289 2271 dbSNP
rs1024350836 2277 dbSNP
rs1375356377 2284 dbSNP
rs1031384778 2291 dbSNP
rs997608488 2298 dbSNP
rs901479574 2301 dbSNP
rs1398812374 2304 dbSNP
rs1282384579 2314 dbSNP
rs1324066234 2323 dbSNP
rs1039097150 2324 dbSNP
rs943657700 2334 dbSNP
rs1271087050 2336 dbSNP
rs1336027931 2337 dbSNP
rs1205224755 2338 dbSNP
rs1234737378 2338 dbSNP
rs888027439 2340 dbSNP
rs1395807185 2341 dbSNP
rs1054656494 2345 dbSNP
rs531565440 2349 dbSNP
rs376219820 2351 dbSNP
rs577442531 2351 dbSNP
rs1409016241 2366 dbSNP
rs574676068 2369 dbSNP
rs1355834446 2372 dbSNP
rs1403005325 2373 dbSNP
rs900646520 2376 dbSNP
rs929443885 2382 dbSNP
rs919346483 2386 dbSNP
rs1268204849 2387 dbSNP
rs1039314280 2398 dbSNP
rs368992701 2403 dbSNP
rs939363525 2432 dbSNP
rs1474399379 2433 dbSNP
rs1260261478 2435 dbSNP
rs926675813 2436 dbSNP
rs1270171963 2441 dbSNP
rs981174825 2457 dbSNP
rs1437726474 2459 dbSNP
rs1271738461 2462 dbSNP
rs1474870694 2463 dbSNP
rs1186794546 2470 dbSNP
rs970032253 2472 dbSNP
rs561037727 2483 dbSNP
rs1319644995 2497 dbSNP
rs1162390694 2498 dbSNP
rs77415906 2505 dbSNP
rs76057578 2506 dbSNP
rs929437620 2509 dbSNP
rs1407079165 2515 dbSNP
rs755457973 2516 dbSNP
rs1232467821 2531 dbSNP
rs374919534 2533 dbSNP
rs955832700 2542 dbSNP
rs1431710949 2545 dbSNP
rs1272103581 2549 dbSNP
rs1380886194 2551 dbSNP
rs1245267911 2556 dbSNP
rs577129193 2558 dbSNP
rs1292602646 2570 dbSNP
rs1362216651 2575 dbSNP
rs1448719223 2583 dbSNP
rs983616221 2587 dbSNP
rs1176772383 2588 dbSNP
rs558649293 2589 dbSNP
rs534008341 2592 dbSNP
rs950376308 2595 dbSNP
rs997303337 2599 dbSNP
rs1030410241 2604 dbSNP
rs962530568 2605 dbSNP
rs868678541 2614 dbSNP
rs1218407536 2616 dbSNP
rs1249438846 2619 dbSNP
rs1460233755 2626 dbSNP
rs901571385 2637 dbSNP
rs780751786 2639 dbSNP
rs1385376069 2641 dbSNP
rs1473722229 2647 dbSNP
rs1182786795 2650 dbSNP
rs1384199964 2657 dbSNP
rs1470127851 2658 dbSNP
rs979989957 2662 dbSNP
rs1322320137 2665 dbSNP
rs1231669606 2667 dbSNP
rs1452280128 2667 dbSNP
rs1179047581 2671 dbSNP
rs1315805929 2678 dbSNP
rs971283991 2679 dbSNP
rs1237480283 2681 dbSNP
rs1279449400 2684 dbSNP
rs1017309582 2685 dbSNP
rs1207194248 2687 dbSNP
rs1458669084 2687 dbSNP
rs1459689668 2688 dbSNP
rs1258326269 2689 dbSNP
rs1212631976 2690 dbSNP
rs533391379 2691 dbSNP
rs1363100915 2692 dbSNP
rs1291820757 2698 dbSNP
rs1161098220 2704 dbSNP
rs888038710 2708 dbSNP
rs1427018224 2724 dbSNP
rs371926728 2728 dbSNP
rs1049265621 2733 dbSNP
rs1469466317 2735 dbSNP
rs766753931 2738 dbSNP
rs763097203 2743 dbSNP
rs1389683454 2750 dbSNP
rs573133180 2758 dbSNP
rs1328272525 2771 dbSNP
rs1336863090 2773 dbSNP
rs993647063 2782 dbSNP
rs1010303100 2815 dbSNP
rs368568048 2816 dbSNP
rs1224541704 2821 dbSNP
rs1277643297 2823 dbSNP
rs1449121122 2824 dbSNP
rs897971142 2825 dbSNP
rs139937585 2829 dbSNP
rs536590627 2845 dbSNP
rs926690802 2848 dbSNP
rs1266474015 2854 dbSNP
rs1479966924 2855 dbSNP
rs1176920981 2856 dbSNP
rs1045078525 2857 dbSNP
rs946659146 2860 dbSNP
rs6598661 2861 dbSNP
rs990037579 2862 dbSNP
rs1166016468 2867 dbSNP
rs771947785 2868 dbSNP
rs955927417 2869 dbSNP
rs1345458241 2871 dbSNP
rs770597959 2877 dbSNP
rs1405868670 2884 dbSNP
rs1400425638 2891 dbSNP
rs1047747592 2900 dbSNP
rs929317371 2911 dbSNP
rs1250250288 2923 dbSNP
rs1160920617 2931 dbSNP
rs924492485 2932 dbSNP
rs976317944 2935 dbSNP
rs1238298347 2937 dbSNP
rs1490166719 2939 dbSNP
rs1199872480 2954 dbSNP
rs1192438732 2958 dbSNP
rs1269267273 2961 dbSNP
rs1487333667 2963 dbSNP
rs1192798229 2968 dbSNP
rs1373886936 2973 dbSNP
rs965856402 2982 dbSNP
rs938058154 2996 dbSNP
rs1222050520 3009 dbSNP
rs1365430135 3013 dbSNP
rs1425924898 3018 dbSNP
rs1295640231 3031 dbSNP
rs1316068228 3031 dbSNP
rs1017739134 3038 dbSNP
rs1380143652 3042 dbSNP
rs1294363404 3045 dbSNP
rs1365503947 3046 dbSNP
rs1229901806 3047 dbSNP
rs371717553 3051 dbSNP
rs1222274126 3052 dbSNP
rs1358623072 3052 dbSNP
rs1266952405 3054 dbSNP
rs1204354086 3065 dbSNP
rs1484748118 3065 dbSNP
rs979896915 3066 dbSNP
rs949997929 3075 dbSNP
rs1181824993 3079 dbSNP
rs542960110 3079 dbSNP
rs951693761 3082 dbSNP
rs1027878487 3083 dbSNP
rs1167577944 3084 dbSNP
rs988718849 3087 dbSNP
rs1453438736 3088 dbSNP
rs1289835244 3093 dbSNP
rs1232181709 3094 dbSNP
rs1370008397 3106 dbSNP
rs1436901064 3118 dbSNP
rs1032642712 3119 dbSNP
rs1334088489 3119 dbSNP
rs955909065 3119 dbSNP
rs1314716154 3120 dbSNP
rs1315069502 3121 dbSNP
rs1294277998 3131 dbSNP
rs993732540 3139 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 79801.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaucGGA-GGUA----CUUAAGACUac 5'
              |:| ||:|    | |||||||  
Target 5' uucuCUUACCGUUACAGUAUUCUGA-- 3'
6 - 30
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177600. RNA binding protein: AGO2. Condition:p53_V_Ago_CLIP_2_2 PAR-CLIP data was present in ERX177602. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_4 PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 PAR-CLIP data was present in ERX177608. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_10 PAR-CLIP data was present in ERX177609. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_11 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 PAR-CLIP data was present in ERX177612. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_2 PAR-CLIP data was present in ERX177614. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_4 PAR-CLIP data was present in ERX177617. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_7 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177620. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_10 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 PAR-CLIP data was present in ERX177626. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_4 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 PAR-CLIP data was present in ERX177632. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_10 PAR-CLIP data was present in ERX177633. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_11 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760632. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000303383.3 | 3UTR | UAUUUUUCUCUUACCGUUACAGUAUUCUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC 0.993 0 1.000 0.5 4 Click to see details
LUSC -0.456 0.04 -0.496 0.03 15 Click to see details
BRCA 0.287 0.06 0.276 0.07 31 Click to see details
STAD 0.943 0.11 1.000 0.5 3 Click to see details
UCEC 0.811 0.2 0.500 0.33 3 Click to see details
BLCA 0.39 0.22 0.600 0.1 6 Click to see details
HNSC 0.207 0.24 0.345 0.11 14 Click to see details
HNSC 0.207 0.24 0.345 0.11 14 Click to see details
HNSC 0.207 0.24 0.345 0.11 14 Click to see details
HNSC 0.207 0.24 0.345 0.11 14 Click to see details
HNSC 0.207 0.24 0.345 0.11 14 Click to see details
HNSC 0.207 0.24 0.345 0.11 14 Click to see details
HNSC 0.207 0.24 0.345 0.11 14 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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