miRTarBase - #MIRT534739


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pre-miRNA Information
pre-miRNA hsa-mir-216b   
Genomic Coordinates chr2: 56000714 - 56000795
Description Homo sapiens miR-216b stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216b-5p
Sequence 11| AAAUCUCUGCAGGCAAAUGUGA |32
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs746268253 9 dbSNP
rs777165632 10 dbSNP
rs528642031 11 dbSNP
rs1168114631 14 dbSNP
rs559876972 16 dbSNP
rs1415888803 17 dbSNP
rs756876970 18 dbSNP
rs930279879 18 dbSNP
rs777776673 19 dbSNP
rs1182789155 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B5PHM2 miR-216b Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol RBM47   
Synonyms NET18
Description RNA binding motif protein 47
Transcript NM_001098634   
Other Transcripts NM_019027   
Expression
Putative miRNA Targets on RBM47
3'UTR of RBM47
(miRNA target sites are highlighted)		 
>RBM47|NM_001098634|3'UTR
   1 GGCTGGTGACCAGCACGAAGACAGACCACACAAACACCACTGAAGGAACGCTTGACTATTTATGAAGAAGGAACATGTTG
  81 GATTCACACATGCAACCTGAAAGTGAAGAATGTTAGCAGATTTATTTCTGAATTATTTTATATACATGAAGTTTTCACTA
 161 GTTTTTTAAGACTATTTTCAACTTAGCATGCCTACGTTCATACATTTCCAAAAGACTTGCAATGGTTCGTGCCTTCATTC
 241 CATCTTTTAAAAATTTGTATGCTGTACTACATTTGTATAGAGGTTTTTGTTGTTGTTTTTTTAAGGATATATTTTCAGTA
 321 TGAAGGTTATTTTCTTAACTTCTGCACTCCAGAGATTTCTATTTTGTAGTACCTTCAATAATATATCAACTATATATTAA
 401 AAAAGCACACTTGAGGAGCTAGGGAACTATTTTGAAAAATATATACAATATTTAAAGATACAAACAGTAGTGCTTAAAAA
 481 TACTACATAAAGCATTATTTTAAAGGTTATACTGGAAAGTGCAATTTTAAAATGAGTAAAACCTCTGTATTTCTGCTGGC
 561 ATTAAGGGTTGATGGTGTTACCATGTATCATCATGGCGGTACTATTTTTTAAAAGAAATTAAACACTGGATCTCTCCTTA
 641 AGCCAACATTGAAAAGACTTGCCGCACTTCTGAGTCCAAACACTGGAAAGCTCTCCTTTGCCACCGTTAGCCGGGGCTCA
 721 TTCTCCATGTGCCTTAGCCTTAAACATGCCCCCACTCCCACATCTCTCACCCTGTCCCCTCCTCCCCAGATTCCCAATCC
 801 CACCGCAATGTTTGGCAAGCCTAGGACTGATAAGTAGCTCTGATAGAGGAGCTGGTGGCTTTTATACTTCTTCCTGGGTT
 881 TTTGTTGGGGTTTGTTGTTTCGTTGTTTTTTGTTTTTTTTTTTGTTTGGTTGGGGAAGTATTGTCTTCTACGTGTGCTAT
 961 TTTCAGTAGCAGAGTAAGCACAAGGTTTTAATCGAGTTGCATAAGACACCTTTGCATAGCTATTTAATTGCCCAATGTAA
1041 AACTTTAATGCCATTTCTAATGCTTTTATTCATTTTTGAAGTATGAGTTTGTAGGGACAAAGAATGTATGTTATCGTAGA
1121 CAAGACCCCCAGAGACTCTTTTCAGCAGAAAGTTATGCTTCTAGTTGCCTTACCATGTTTCTTGCAAAACTGTCCATGGT
1201 CCTCAAGGGTGTTGGAAACATTATGTTTATTAAATGGGCCTCTCTTCCTTTGCTGTGCACTTGATGGGTGAACTGGATTG
1281 GGGTGTGCACATCCAGGAGGAGGAGGAGAGACCTGTAGAAGTTTAAAGATAGTTTGTAAATATCTTCTAATGCTTGTTTT
1361 TAGTCCTTTTATGTTGGAGAAGTTCATGGTATGTAGTTTAATGCAAAATGAAACCATTTTATTTCAATGTTATTAAAAAG
1441 GTTTGTTTTATTAGGAAGTTAATGTATTGTTGCAGTGTTTTGTGCCTGTTTAAAGGCTTTTGTTTAGCAGAGTGAATGTA
1521 AAATACAGTAAAATGTTAAGATTGTCATCTACTTTTTAAAAAAAAATATCAACTTGGAATTGTTTTTTAAAGGCTCAATC
1601 AAGGAAGTGAGGTGTGCAATAAGGTAGCAAGTAAAACGCAGTTGCGTTTTTATGTCATGTTAGAGATCCATACAATTTTC
1681 CACTCACGGGATTTTTGTTGATGGCTGAATTCTTGTGGATTCATAAGAGGATCATGCCCTTAGCAAGTACTTTTGTTTTG
1761 TTTTAAATTAAGAGATTCCCAAATGCCTTTTTCCCCCTCATCTTGAAATGAGATGAGTTTTTATGTGTAAGCAATATTTA
1841 TTTAACTATTCTATAAAATTATTGAGTGCCTACTGAGGCCTTTAAGCACCGCTAACATTCCTTTCCATCATTCTTTTAAA
1921 TGACATAAAATAATTGTGCAATGTTCCTGATGATGTACCCCACAAGCTGCATTCAAACTCAAATCTGTGGGAATGAGTGA
2001 CTCGACAAAATGTAATTCGGATCAGATCCTCATCCCCTGACTGTGTGAAAAAAGTACTCTCCTTCTAGTGAAGGATTGTC
2081 ACAGAGTTTCACTGGATGAAACTATGACCCAGTATTCTTACTGTATTTTACATATGCCTGTAAATTATTTGCAAAAAAGA
2161 AGAAGAAGAGGAAGAAAGAAAAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAG
2241 AAAGAAAGAAAAAGAAAGAAAGAATAAAAAAAAATGATAACATGGCAACCACCAAACTCCCTTAAAAACAAACATTGGTG
2321 ACATGGCCAATTAAGTATCAGTGAGCCTCCTATCTGGGACTTATCTGTTCCTATTGTTTCAAAACCATTTCATGTACACT
2401 ACTGAGGTAAGTTTATAACTTGAAATGTGAACTTTTTTTTTTTTTAGTGTTAAGAACAAACTATATAAATGTAAAAAAAA
2481 AGTTTTAGAGTTCTGTTTTCAAACATTGCTAGTGGTTTAGTTAACTTTAGCTGCTTTATATTTGAAAAGCTTTTATTTAG
2561 ATCTTGCTCCATTTACAGTACATTCTTAGGATGTATGTAGTAAATAAAGCTTTCTTTAAAGCAATCGCAAGACCTTATTT
2641 TAAATTGTGAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUGUAAACG-GACGUCUCUAAa 5'
            || | ||| || |||||||| 
Target 5' taACTTCTGCACTCCAGAGATTt 3'
 336 - 358 168.00 -14.60
2 
miRNA  3' agUGUAAACGGACGUCUCUAAa 5'
            |||||||  | :||||:|| 
Target 5' ctACATTTG--TATAGAGGTTt 3'
 267 - 286 152.00 -16.80
3 
miRNA  3' agUGUAAAC-GGACG---------UCUCUAAa 5'
            || |||| ::||:         ||||||| 
Target 5' gtACTTTTGTTTTGTTTTAAATTAAGAGATTc 3'
 1747 - 1778 148.00 -9.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30460922 1 COSMIC
COSN26991805 2 COSMIC
COSN30455666 17 COSMIC
COSN30479997 24 COSMIC
COSN30587470 49 COSMIC
COSN30104583 59 COSMIC
COSN31562220 87 COSMIC
COSN31595071 97 COSMIC
COSN2028221 132 COSMIC
COSN6580524 229 COSMIC
COSN5060446 255 COSMIC
COSN16747820 410 COSMIC
COSN23048979 597 COSMIC
COSN17506065 611 COSMIC
COSN31590836 659 COSMIC
COSN8490726 685 COSMIC
COSN28735280 696 COSMIC
COSN17078616 726 COSMIC
COSN20099973 913 COSMIC
COSN15992132 1193 COSMIC
COSN6830497 1257 COSMIC
COSN31585000 1437 COSMIC
COSN19657563 1462 COSMIC
COSN9040287 1464 COSMIC
COSN31514085 1557 COSMIC
COSN17125431 1667 COSMIC
COSN31530566 1913 COSMIC
COSN28637470 2051 COSMIC
COSN31606197 2057 COSMIC
COSN26633623 2058 COSMIC
COSN26577331 2152 COSMIC
COSN14515181 2213 COSMIC
COSN26043714 2220 COSMIC
COSN7490346 2247 COSMIC
COSN29008989 2432 COSMIC
COSN27250232 2433 COSMIC
COSN18798238 2493 COSMIC
COSN15668151 2500 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs142516725 5 dbSNP
rs201195667 6 dbSNP
rs1337978378 7 dbSNP
rs754135511 8 dbSNP
rs1305141306 10 dbSNP
rs766335624 13 dbSNP
rs756281770 15 dbSNP
rs750879476 16 dbSNP
rs139448141 17 dbSNP
rs1281362956 20 dbSNP
rs747243554 27 dbSNP
rs1444096408 32 dbSNP
rs183247813 33 dbSNP
rs1184202201 35 dbSNP
rs371818265 35 dbSNP
rs554507131 39 dbSNP
rs1258793610 42 dbSNP
rs1214593071 43 dbSNP
rs764603609 47 dbSNP
rs554684608 49 dbSNP
rs1243064666 50 dbSNP
rs1479351161 51 dbSNP
rs1211270731 63 dbSNP
rs1463056222 74 dbSNP
rs943000525 75 dbSNP
rs1269082937 79 dbSNP
rs910501831 81 dbSNP
rs534663983 82 dbSNP
rs979337691 94 dbSNP
rs371728515 116 dbSNP
rs1020747463 117 dbSNP
rs1199140470 118 dbSNP
rs546544682 130 dbSNP
rs1430789291 134 dbSNP
rs1171674858 135 dbSNP
rs956120408 141 dbSNP
rs1035670389 144 dbSNP
rs147542798 146 dbSNP
rs143298391 150 dbSNP
rs1404154754 153 dbSNP
rs1301043266 157 dbSNP
rs550782622 174 dbSNP
rs139310463 194 dbSNP
rs1294686267 215 dbSNP
rs561766327 218 dbSNP
rs887944569 221 dbSNP
rs887420757 225 dbSNP
rs1047864673 228 dbSNP
rs1049034353 229 dbSNP
rs1358243995 255 dbSNP
rs1222275432 262 dbSNP
rs931866273 266 dbSNP
rs548306117 275 dbSNP
rs1211164721 277 dbSNP
rs1334889804 281 dbSNP
rs1386152222 289 dbSNP
rs1257107211 292 dbSNP
rs73231732 295 dbSNP
rs1161865333 296 dbSNP
rs559313643 296 dbSNP
rs1272248541 298 dbSNP
rs1432134398 306 dbSNP
rs1288275438 307 dbSNP
rs1359778575 320 dbSNP
rs149602123 321 dbSNP
rs1331082357 329 dbSNP
rs944503361 345 dbSNP
rs1315108023 346 dbSNP
rs1381340008 351 dbSNP
rs943051286 361 dbSNP
rs1285829349 376 dbSNP
rs192123521 378 dbSNP
rs1216934986 387 dbSNP
rs912649243 389 dbSNP
rs563672674 392 dbSNP
rs1463139027 394 dbSNP
rs977452430 399 dbSNP
rs1206073680 405 dbSNP
rs370556488 406 dbSNP
rs778521338 410 dbSNP
rs1181992483 413 dbSNP
rs946619702 416 dbSNP
rs1419525182 419 dbSNP
rs754978233 419 dbSNP
rs867697807 424 dbSNP
rs1421432095 426 dbSNP
rs867336915 427 dbSNP
rs958985879 432 dbSNP
rs987967975 436 dbSNP
rs960803924 439 dbSNP
rs1034966276 443 dbSNP
rs552263913 445 dbSNP
rs1404728919 447 dbSNP
rs1003053582 448 dbSNP
rs1035763268 458 dbSNP
rs543599766 464 dbSNP
rs1373598795 468 dbSNP
rs971934267 474 dbSNP
rs1014703486 476 dbSNP
rs1244952696 481 dbSNP
rs1225894875 492 dbSNP
rs1264242037 494 dbSNP
rs1460974044 513 dbSNP
rs981481998 545 dbSNP
rs1481070802 548 dbSNP
rs970069439 552 dbSNP
rs1022879593 566 dbSNP
rs1468580082 572 dbSNP
rs1006899861 575 dbSNP
rs1481257362 577 dbSNP
rs1177080289 581 dbSNP
rs574737626 582 dbSNP
rs1467832453 583 dbSNP
rs868225624 587 dbSNP
rs554603157 590 dbSNP
rs1330272475 591 dbSNP
rs996128006 597 dbSNP
rs1407669817 598 dbSNP
rs900422859 603 dbSNP
rs1349035996 608 dbSNP
rs535135094 611 dbSNP
rs1040655047 615 dbSNP
rs944573205 622 dbSNP
rs923741474 627 dbSNP
rs1323414834 633 dbSNP
rs1217596041 634 dbSNP
rs1041812578 638 dbSNP
rs572323834 643 dbSNP
rs1204096659 644 dbSNP
rs914615317 645 dbSNP
rs1490794975 646 dbSNP
rs749114106 648 dbSNP
rs902005656 649 dbSNP
rs958924616 657 dbSNP
rs867736768 658 dbSNP
rs1169540115 662 dbSNP
rs558890517 663 dbSNP
rs538693171 664 dbSNP
rs73231731 671 dbSNP
rs1367048237 682 dbSNP
rs1249447975 690 dbSNP
rs1407189278 695 dbSNP
rs1304110415 700 dbSNP
rs1345221029 704 dbSNP
rs888792365 706 dbSNP
rs1015080611 713 dbSNP
rs1434984245 713 dbSNP
rs1362766098 714 dbSNP
rs1214044386 715 dbSNP
rs1371827751 716 dbSNP
rs1272832371 717 dbSNP
rs1361816881 719 dbSNP
rs1330722081 720 dbSNP
rs1444873415 727 dbSNP
rs1004672063 728 dbSNP
rs1290805122 738 dbSNP
rs1449593466 743 dbSNP
rs1195258391 744 dbSNP
rs1043383182 746 dbSNP
rs1474833961 751 dbSNP
rs1027371330 753 dbSNP
rs995858580 754 dbSNP
rs946643398 762 dbSNP
rs550943726 764 dbSNP
rs1365344435 774 dbSNP
rs913841873 776 dbSNP
rs1052768332 778 dbSNP
rs1422784951 780 dbSNP
rs939231383 784 dbSNP
rs537199843 787 dbSNP
rs1327522574 791 dbSNP
rs187160260 797 dbSNP
rs1295462407 800 dbSNP
rs1385018507 801 dbSNP
rs1246998469 802 dbSNP
rs902369233 804 dbSNP
rs1042200444 805 dbSNP
rs1314564688 805 dbSNP
rs1379179695 829 dbSNP
rs547940344 830 dbSNP
rs1446334692 837 dbSNP
rs1206689891 848 dbSNP
rs893231417 849 dbSNP
rs1054432317 857 dbSNP
rs1182611127 870 dbSNP
rs1233165016 878 dbSNP
rs970079505 884 dbSNP
rs757420286 886 dbSNP
rs915932419 889 dbSNP
rs981748185 892 dbSNP
rs984834612 895 dbSNP
rs182194041 901 dbSNP
rs983626465 902 dbSNP
rs1240985134 903 dbSNP
rs200966597 912 dbSNP
rs1026603818 913 dbSNP
rs1349635587 913 dbSNP
rs1264861317 914 dbSNP
rs994153975 916 dbSNP
rs1202474979 918 dbSNP
rs966204497 919 dbSNP
rs1278546233 920 dbSNP
rs199991649 923 dbSNP
rs1164747111 924 dbSNP
rs1439170421 924 dbSNP
rs1472436667 924 dbSNP
rs3832277 924 dbSNP
rs397993070 924 dbSNP
rs80189921 924 dbSNP
rs1019089481 928 dbSNP
rs1432078173 928 dbSNP
rs1470367616 928 dbSNP
rs1007328863 929 dbSNP
rs1334960228 940 dbSNP
rs1238111436 943 dbSNP
rs1375618097 944 dbSNP
rs1285183059 948 dbSNP
rs1299017194 951 dbSNP
rs888844465 952 dbSNP
rs74741526 954 dbSNP
rs1196033475 957 dbSNP
rs1249366544 961 dbSNP
rs1482972622 966 dbSNP
rs369156760 985 dbSNP
rs1010599701 993 dbSNP
rs902432579 1000 dbSNP
rs1481065496 1001 dbSNP
rs892115868 1003 dbSNP
rs189909201 1004 dbSNP
rs1314435403 1009 dbSNP
rs755001609 1015 dbSNP
rs1052399725 1016 dbSNP
rs939230634 1023 dbSNP
rs1427619845 1025 dbSNP
rs532050146 1035 dbSNP
rs1435078528 1036 dbSNP
rs1359866285 1039 dbSNP
rs1345856836 1043 dbSNP
rs1156764044 1048 dbSNP
rs563636481 1050 dbSNP
rs927807842 1061 dbSNP
rs543716633 1071 dbSNP
rs1386169568 1079 dbSNP
rs1299019875 1081 dbSNP
rs569974206 1084 dbSNP
rs1227515193 1091 dbSNP
rs1250454227 1093 dbSNP
rs1339608787 1095 dbSNP
rs947873907 1096 dbSNP
rs916027229 1099 dbSNP
rs138224364 1109 dbSNP
rs1490597422 1113 dbSNP
rs1191140684 1114 dbSNP
rs1265866180 1115 dbSNP
rs1471584632 1116 dbSNP
rs1255880828 1120 dbSNP
rs1430442756 1122 dbSNP
rs1193948736 1123 dbSNP
rs1389831402 1126 dbSNP
rs1198340270 1127 dbSNP
rs1447912694 1143 dbSNP
rs1165662400 1145 dbSNP
rs1365965272 1146 dbSNP
rs1457207915 1149 dbSNP
rs1054561511 1164 dbSNP
rs561169714 1175 dbSNP
rs1382346614 1176 dbSNP
rs1296262750 1185 dbSNP
rs1362352886 1186 dbSNP
rs1247727529 1191 dbSNP
rs905900338 1192 dbSNP
rs1286013967 1196 dbSNP
rs1214260869 1203 dbSNP
rs919212431 1204 dbSNP
rs1487121642 1211 dbSNP
rs1206186042 1213 dbSNP
rs541293480 1216 dbSNP
rs1247526233 1218 dbSNP
rs1307711074 1230 dbSNP
rs150426578 1236 dbSNP
rs966256668 1242 dbSNP
rs278982 1244 dbSNP
rs1423070680 1248 dbSNP
rs1007754356 1249 dbSNP
rs983679377 1254 dbSNP
rs1454279293 1256 dbSNP
rs1319735962 1263 dbSNP
rs930811118 1264 dbSNP
rs1454109091 1267 dbSNP
rs796576377 1270 dbSNP
rs530691455 1272 dbSNP
rs1339578642 1282 dbSNP
rs1377946366 1282 dbSNP
rs974541710 1283 dbSNP
rs1311053296 1295 dbSNP
rs568771964 1308 dbSNP
rs1018646867 1309 dbSNP
rs1345299538 1309 dbSNP
rs1163408410 1313 dbSNP
rs987552840 1324 dbSNP
rs1403077879 1329 dbSNP
rs1244028591 1336 dbSNP
rs1483061391 1342 dbSNP
rs1180299097 1344 dbSNP
rs185840715 1349 dbSNP
rs892131175 1352 dbSNP
rs1419393973 1354 dbSNP
rs576510369 1355 dbSNP
rs140561416 1362 dbSNP
rs867875722 1366 dbSNP
rs1003426370 1373 dbSNP
rs906485837 1383 dbSNP
rs1409651283 1386 dbSNP
rs1470691449 1387 dbSNP
rs1010751081 1388 dbSNP
rs537356741 1389 dbSNP
rs957897512 1391 dbSNP
rs1033914733 1392 dbSNP
rs1445398504 1395 dbSNP
rs1001658732 1414 dbSNP
rs1044949399 1416 dbSNP
rs75361409 1421 dbSNP
rs1288315436 1426 dbSNP
rs554726152 1433 dbSNP
rs888276223 1441 dbSNP
rs1225838958 1445 dbSNP
rs181156538 1450 dbSNP
rs1311613849 1451 dbSNP
rs1208304612 1453 dbSNP
rs1487107892 1486 dbSNP
rs1014280573 1491 dbSNP
rs1049148056 1528 dbSNP
rs1261803703 1529 dbSNP
rs775844596 1530 dbSNP
rs930687894 1540 dbSNP
rs1181148390 1542 dbSNP
rs1275342603 1544 dbSNP
rs919279062 1547 dbSNP
rs930863530 1552 dbSNP
rs1412210362 1557 dbSNP
rs565757525 1558 dbSNP
rs552032249 1563 dbSNP
rs1039603887 1564 dbSNP
rs1430856280 1565 dbSNP
rs1348974343 1567 dbSNP
rs943516785 1567 dbSNP
rs911634952 1568 dbSNP
rs944670854 1570 dbSNP
rs1293122545 1582 dbSNP
rs138801206 1585 dbSNP
rs112597102 1590 dbSNP
rs1217546973 1591 dbSNP
rs1362638523 1592 dbSNP
rs1343107699 1593 dbSNP
rs1292844455 1596 dbSNP
rs1204636075 1601 dbSNP
rs569326174 1607 dbSNP
rs1396017476 1619 dbSNP
rs1165212868 1623 dbSNP
rs913559560 1630 dbSNP
rs1222236072 1635 dbSNP
rs989382562 1637 dbSNP
rs953563828 1638 dbSNP
rs1022844328 1641 dbSNP
rs188290404 1645 dbSNP
rs1187743203 1646 dbSNP
rs957938613 1650 dbSNP
rs1166257559 1653 dbSNP
rs989251547 1654 dbSNP
rs530308321 1657 dbSNP
rs956629200 1658 dbSNP
rs1369116242 1659 dbSNP
rs1033565942 1663 dbSNP
rs183624687 1670 dbSNP
rs1263129337 1672 dbSNP
rs1434458334 1676 dbSNP
rs1003193429 1687 dbSNP
rs192269890 1688 dbSNP
rs906203995 1699 dbSNP
rs1295601178 1700 dbSNP
rs1361402044 1704 dbSNP
rs565073192 1705 dbSNP
rs190823694 1706 dbSNP
rs1254891298 1708 dbSNP
rs886462583 1712 dbSNP
rs1217810968 1727 dbSNP
rs1012080794 1730 dbSNP
rs1464005807 1735 dbSNP
rs565336202 1737 dbSNP
rs995121654 1744 dbSNP
rs370894029 1774 dbSNP
rs888294854 1783 dbSNP
rs1474003073 1787 dbSNP
rs528183445 1789 dbSNP
rs1249817168 1792 dbSNP
rs1413461248 1795 dbSNP
rs536369010 1796 dbSNP
rs899422004 1797 dbSNP
rs148765896 1800 dbSNP
rs1307859703 1823 dbSNP
rs943553099 1827 dbSNP
rs1318861051 1848 dbSNP
rs1231919039 1849 dbSNP
rs912037243 1862 dbSNP
rs1245734248 1870 dbSNP
rs1283414630 1873 dbSNP
rs545184234 1881 dbSNP
rs1051490053 1888 dbSNP
rs1225406585 1888 dbSNP
rs368196627 1890 dbSNP
rs185467184 1891 dbSNP
rs11660 1892 dbSNP
rs1393927671 1894 dbSNP
rs913611981 1905 dbSNP
rs1036433460 1907 dbSNP
rs1186346330 1913 dbSNP
rs1237266834 1920 dbSNP
rs1471979479 1925 dbSNP
rs957660442 1926 dbSNP
rs1413334627 1928 dbSNP
rs1456816110 1936 dbSNP
rs1463903162 1941 dbSNP
rs926550141 1943 dbSNP
rs944723296 1951 dbSNP
rs145599320 1953 dbSNP
rs574767929 1957 dbSNP
rs1333689898 1958 dbSNP
rs1338546898 1969 dbSNP
rs1444108434 1971 dbSNP
rs1288958758 1973 dbSNP
rs368667381 1975 dbSNP
rs1226444298 1976 dbSNP
rs1396988074 1978 dbSNP
rs1345021134 1979 dbSNP
rs1199535751 1980 dbSNP
rs915423922 1994 dbSNP
rs1441112360 1996 dbSNP
rs754513080 1999 dbSNP
rs1024790037 2001 dbSNP
rs373960073 2003 dbSNP
rs992951705 2011 dbSNP
rs1379461409 2012 dbSNP
rs1466605984 2018 dbSNP
rs747766276 2019 dbSNP
rs575311508 2021 dbSNP
rs767993190 2028 dbSNP
rs994842890 2029 dbSNP
rs140421653 2031 dbSNP
rs970372119 2034 dbSNP
rs552452485 2038 dbSNP
rs375352610 2041 dbSNP
rs1007798689 2057 dbSNP
rs73231729 2058 dbSNP
rs1272757776 2065 dbSNP
rs1051879350 2073 dbSNP
rs1238877557 2074 dbSNP
rs1205366206 2080 dbSNP
rs945511894 2081 dbSNP
rs892216052 2082 dbSNP
rs888339331 2084 dbSNP
rs936346295 2087 dbSNP
rs926294774 2091 dbSNP
rs1198227614 2097 dbSNP
rs558586985 2104 dbSNP
rs1026885926 2105 dbSNP
rs1169387211 2107 dbSNP
rs981119134 2110 dbSNP
rs1391538094 2112 dbSNP
rs994434612 2116 dbSNP
rs1397689574 2117 dbSNP
rs949327661 2125 dbSNP
rs748253534 2147 dbSNP
rs917789628 2153 dbSNP
rs896978781 2154 dbSNP
rs1385780922 2159 dbSNP
rs1036487720 2162 dbSNP
rs1232478415 2166 dbSNP
rs1008944894 2167 dbSNP
rs1377843918 2170 dbSNP
rs1366658330 2174 dbSNP
rs151215159 2176 dbSNP
rs569440702 2179 dbSNP
rs368469839 2180 dbSNP
rs1174811641 2187 dbSNP
rs932268224 2188 dbSNP
rs1226614516 2189 dbSNP
rs201298966 2190 dbSNP
rs1209728957 2191 dbSNP
rs1447475663 2191 dbSNP
rs1489108660 2191 dbSNP
rs200814411 2191 dbSNP
rs67486138 2191 dbSNP
rs1368780367 2192 dbSNP
rs1435182291 2192 dbSNP
rs1457373488 2192 dbSNP
rs36086958 2192 dbSNP
rs66940499 2192 dbSNP
rs1290731835 2193 dbSNP
rs1319524551 2193 dbSNP
rs1362556238 2193 dbSNP
rs796256141 2193 dbSNP
rs1362076359 2194 dbSNP
rs1322628419 2195 dbSNP
rs1244712115 2196 dbSNP
rs1264187091 2196 dbSNP
rs1331390824 2196 dbSNP
rs398051153 2196 dbSNP
rs1209402197 2197 dbSNP
rs1184254611 2198 dbSNP
rs1183775922 2199 dbSNP
rs1374237478 2199 dbSNP
rs1423015547 2199 dbSNP
rs1463729824 2199 dbSNP
rs1157804166 2200 dbSNP
rs1162680081 2200 dbSNP
rs376284136 2200 dbSNP
rs746854160 2200 dbSNP
rs756855912 2200 dbSNP
rs1303003320 2203 dbSNP
rs1380417137 2203 dbSNP
rs1385761865 2203 dbSNP
rs1467268238 2203 dbSNP
rs1229497193 2204 dbSNP
rs1352843724 2204 dbSNP
rs1395801409 2204 dbSNP
rs201057532 2204 dbSNP
rs371378298 2204 dbSNP
rs758291487 2204 dbSNP
rs1256806229 2205 dbSNP
rs1419855564 2205 dbSNP
rs764790955 2205 dbSNP
rs1255244366 2206 dbSNP
rs1491009202 2206 dbSNP
rs982620706 2206 dbSNP
rs1181284025 2207 dbSNP
rs1253648567 2207 dbSNP
rs1409141631 2207 dbSNP
rs1472897640 2207 dbSNP
rs1311464976 2208 dbSNP
rs1358183625 2208 dbSNP
rs1415666437 2208 dbSNP
rs1465896561 2208 dbSNP
rs764032997 2208 dbSNP
rs1372755620 2210 dbSNP
rs1208512268 2211 dbSNP
rs1288256554 2211 dbSNP
rs1371366274 2211 dbSNP
rs1410977995 2211 dbSNP
rs1208954362 2212 dbSNP
rs1276520131 2212 dbSNP
rs1302306085 2212 dbSNP
rs1311852761 2212 dbSNP
rs879676218 2212 dbSNP
rs1486526188 2213 dbSNP
rs915509438 2213 dbSNP
rs771869588 2214 dbSNP
rs1249520941 2215 dbSNP
rs1281024982 2215 dbSNP
rs1054034039 2216 dbSNP
rs1191243920 2216 dbSNP
rs1431124706 2216 dbSNP
rs1478746170 2216 dbSNP
rs1215732514 2217 dbSNP
rs1392433638 2217 dbSNP
rs935539434 2217 dbSNP
rs1430800501 2218 dbSNP
rs1308006209 2219 dbSNP
rs1347925168 2219 dbSNP
rs1353248383 2219 dbSNP
rs1261925346 2220 dbSNP
rs1300073939 2220 dbSNP
rs924074656 2220 dbSNP
rs1342688743 2222 dbSNP
rs1227352962 2223 dbSNP
rs1222162705 2224 dbSNP
rs1270852967 2224 dbSNP
rs1453277013 2224 dbSNP
rs1466705313 2224 dbSNP
rs981834164 2224 dbSNP
rs1190184210 2226 dbSNP
rs1390371869 2227 dbSNP
rs1166039094 2228 dbSNP
rs1168377436 2228 dbSNP
rs1417767183 2228 dbSNP
rs1450536822 2228 dbSNP
rs970422799 2228 dbSNP
rs1239342097 2229 dbSNP
rs759237817 2230 dbSNP
rs1339553242 2231 dbSNP
rs1268228847 2232 dbSNP
rs1322849017 2232 dbSNP
rs1434580474 2232 dbSNP
rs1438792291 2232 dbSNP
rs781120340 2232 dbSNP
rs916267548 2233 dbSNP
rs1228832120 2234 dbSNP
rs1413396867 2234 dbSNP
rs770053547 2234 dbSNP
rs1210033382 2235 dbSNP
rs1240736442 2236 dbSNP
rs1248052468 2236 dbSNP
rs1464186901 2236 dbSNP
rs753499865 2236 dbSNP
rs1473973527 2238 dbSNP
rs748750338 2238 dbSNP
rs990916284 2238 dbSNP
rs1357750050 2240 dbSNP
rs760429769 2240 dbSNP
rs769141458 2240 dbSNP
rs952398717 2240 dbSNP
rs1389416160 2241 dbSNP
rs1027348848 2242 dbSNP
rs1314039446 2242 dbSNP
rs1342102080 2242 dbSNP
rs1456917720 2242 dbSNP
rs1283576145 2243 dbSNP
rs1400568468 2243 dbSNP
rs1203066663 2244 dbSNP
rs1230112431 2244 dbSNP
rs1268217508 2244 dbSNP
rs1184885404 2246 dbSNP
rs1188657209 2246 dbSNP
rs1257198487 2246 dbSNP
rs1280285632 2246 dbSNP
rs1474531997 2246 dbSNP
rs951155543 2246 dbSNP
rs1382922816 2247 dbSNP
rs1412813768 2247 dbSNP
rs1469680650 2247 dbSNP
rs1157116458 2248 dbSNP
rs1404589768 2248 dbSNP
rs1415206328 2248 dbSNP
rs745683379 2248 dbSNP
rs1199490392 2250 dbSNP
rs1236220034 2250 dbSNP
rs1276303688 2250 dbSNP
rs1288891746 2250 dbSNP
rs1345311305 2250 dbSNP
rs1349407644 2250 dbSNP
rs1373318758 2250 dbSNP
rs1411598130 2250 dbSNP
rs200152202 2250 dbSNP
rs1160518798 2252 dbSNP
rs1179776228 2252 dbSNP
rs1207995520 2252 dbSNP
rs1247400465 2252 dbSNP
rs1253162263 2252 dbSNP
rs1324992772 2252 dbSNP
rs143561234 2252 dbSNP
rs1437367013 2252 dbSNP
rs1478481021 2252 dbSNP
rs1484863123 2252 dbSNP
rs549063764 2252 dbSNP
rs56334700 2252 dbSNP
rs762281934 2252 dbSNP
rs868506839 2252 dbSNP
rs961505024 2253 dbSNP
rs1193309051 2254 dbSNP
rs1194514216 2254 dbSNP
rs1231031813 2254 dbSNP
rs1232095233 2254 dbSNP
rs1269573522 2254 dbSNP
rs1275734520 2254 dbSNP
rs1339340957 2254 dbSNP
rs1346250030 2254 dbSNP
rs1458567585 2254 dbSNP
rs567948161 2254 dbSNP
rs547780721 2255 dbSNP
rs1169015916 2256 dbSNP
rs1372250641 2256 dbSNP
rs1460410805 2256 dbSNP
rs1164869040 2258 dbSNP
rs1454356226 2262 dbSNP
rs1323528440 2264 dbSNP
rs973457235 2264 dbSNP
rs1366944800 2265 dbSNP
rs1435312861 2265 dbSNP
rs890520114 2265 dbSNP
rs1050480789 2266 dbSNP
rs71600746 2267 dbSNP
rs1476072691 2269 dbSNP
rs527848260 2271 dbSNP
rs1213117235 2275 dbSNP
rs565351221 2275 dbSNP
rs67388577 2275 dbSNP
rs757475046 2282 dbSNP
rs1257881811 2290 dbSNP
rs1008266888 2292 dbSNP
rs142168676 2308 dbSNP
rs1426506784 2309 dbSNP
rs149075742 2310 dbSNP
rs935564831 2314 dbSNP
rs563004187 2315 dbSNP
rs1162208653 2316 dbSNP
rs924125407 2318 dbSNP
rs1030499215 2327 dbSNP
rs1046525709 2329 dbSNP
rs751723249 2333 dbSNP
rs916360934 2335 dbSNP
rs577648090 2337 dbSNP
rs1205244986 2339 dbSNP
rs952524449 2341 dbSNP
rs1380852699 2344 dbSNP
rs1315492245 2352 dbSNP
rs193188024 2357 dbSNP
rs1234688592 2360 dbSNP
rs973066018 2361 dbSNP
rs1209661907 2364 dbSNP
rs1260360167 2371 dbSNP
rs574128049 2371 dbSNP
rs554801720 2375 dbSNP
rs557411710 2376 dbSNP
rs1474841997 2386 dbSNP
rs936414304 2410 dbSNP
rs1294249531 2411 dbSNP
rs143001261 2413 dbSNP
rs200546729 2413 dbSNP
rs34841534 2413 dbSNP
rs1157967027 2415 dbSNP
rs1343046593 2419 dbSNP
rs1325251581 2424 dbSNP
rs1008086114 2427 dbSNP
rs1467215050 2443 dbSNP
rs1258978132 2446 dbSNP
rs1414728787 2446 dbSNP
rs760688662 2446 dbSNP
rs1320842939 2447 dbSNP
rs1382903607 2449 dbSNP
rs1352480534 2464 dbSNP
rs1393755401 2466 dbSNP
rs1163057897 2468 dbSNP
rs1306621089 2470 dbSNP
rs1463170727 2470 dbSNP
rs1418329598 2471 dbSNP
rs1167157348 2472 dbSNP
rs540976729 2473 dbSNP
rs753284950 2474 dbSNP
rs1280798125 2477 dbSNP
rs1208722144 2482 dbSNP
rs1485213347 2482 dbSNP
rs534175752 2482 dbSNP
rs917843405 2482 dbSNP
rs929808557 2487 dbSNP
rs1193796882 2506 dbSNP
rs188233593 2514 dbSNP
rs368311715 2529 dbSNP
rs1467653086 2530 dbSNP
rs996238558 2532 dbSNP
rs893809434 2538 dbSNP
rs1434551540 2540 dbSNP
rs1032315737 2548 dbSNP
rs1215210128 2550 dbSNP
rs1468604268 2551 dbSNP
rs1434484297 2553 dbSNP
rs1311639887 2557 dbSNP
rs1257005055 2560 dbSNP
rs1214392480 2562 dbSNP
rs919746485 2563 dbSNP
rs1000205764 2569 dbSNP
rs973920455 2571 dbSNP
rs902798292 2576 dbSNP
rs1337838720 2596 dbSNP
rs1046620695 2611 dbSNP
rs963493190 2614 dbSNP
rs9998092 2618 dbSNP
rs1308036177 2624 dbSNP
rs1228706358 2625 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 54502.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000319592.4 | 3UTR | UUAUUUUCUUAACUUCUGCACUCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.715 0.04 0.750 0.03 7 Click to see details
THCA 0.293 0.12 0.249 0.16 18 Click to see details
KIRC 0.538 0.14 0.657 0.08 6 Click to see details
BLCA 0.676 0.16 0.800 0.1 4 Click to see details
KICH -0.469 0.21 -0.300 0.31 5 Click to see details
STAD 0.351 0.25 0.371 0.23 6 Click to see details
CHOL -0.34 0.25 -0.486 0.16 6 Click to see details
LUAD 0.658 0.27 0.500 0.33 3 Click to see details
PRAD 0.178 0.31 -0.042 0.45 10 Click to see details
LIHC 0.074 0.32 -0.007 0.48 44 Click to see details
UCEC -0.238 0.42 -0.500 0.33 3 Click to see details
LUSC 0.044 0.47 -0.086 0.44 6 Click to see details
KIRP -0.029 0.49 -0.400 0.3 4 Click to see details
PAAD 0.01 0.5 0.500 0.33 3 Click to see details
PAAD 0.01 0.5 0.500 0.33 3 Click to see details
PAAD 0.01 0.5 0.500 0.33 3 Click to see details
PAAD 0.01 0.5 0.500 0.33 3 Click to see details
PAAD 0.01 0.5 0.500 0.33 3 Click to see details
PAAD 0.01 0.5 0.500 0.33 3 Click to see details
129 hsa-miR-216b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006144 KRAS KRAS proto-oncogene, GTPase 3 1
MIRT007207 CSNK2A1 casein kinase 2 alpha 1 3 1
MIRT064260 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT169957 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 6
MIRT362970 CDK6 cyclin dependent kinase 6 2 2
MIRT437983 BECN1 beclin 1 3 2
MIRT443073 ABLIM1 actin binding LIM protein 1 2 2
MIRT443747 ZFAND5 zinc finger AN1-type containing 5 2 6
MIRT445488 KLF12 Kruppel like factor 12 2 2
MIRT447818 ZCCHC11 zinc finger CCHC-type containing 11 2 2
MIRT448753 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT460391 GUF1 GUF1 homolog, GTPase 2 2
MIRT466481 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472205 NGFRAP1 brain expressed X-linked 3 2 4
MIRT473269 MID1 midline 1 2 2
MIRT489831 P2RY2 purinergic receptor P2Y2 2 2
MIRT497753 OXGR1 oxoglutarate receptor 1 2 2
MIRT502881 CDK4 cyclin dependent kinase 4 2 8
MIRT505904 RIMS3 regulating synaptic membrane exocytosis 3 2 6
MIRT506657 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT510190 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512406 CD84 CD84 molecule 2 2
MIRT520342 UBXN2A UBX domain protein 2A 2 2
MIRT523602 FZD5 frizzled class receptor 5 2 2
MIRT529598 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT534444 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT534739 RBM47 RNA binding motif protein 47 2 2
MIRT537285 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT546979 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT549862 MCM4 minichromosome maintenance complex component 4 2 2
MIRT552535 ZIC5 Zic family member 5 2 2
MIRT555322 PPP2CB protein phosphatase 2 catalytic subunit beta 2 2
MIRT555661 PGM3 phosphoglucomutase 3 2 2
MIRT559128 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT567802 DEK DEK proto-oncogene 2 2
MIRT567866 DCAF12 DDB1 and CUL4 associated factor 12 2 2
MIRT574661 KLHL15 kelch like family member 15 2 2
MIRT575029 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT607227 ACSM2A acyl-CoA synthetase medium chain family member 2A 2 4
MIRT609385 FAM216B family with sequence similarity 216 member B 2 4
MIRT612266 PDZD4 PDZ domain containing 4 2 2
MIRT617434 ANP32E acidic nuclear phosphoprotein 32 family member E 2 4
MIRT619453 NUP214 nucleoporin 214 2 2
MIRT620242 CCDC65 coiled-coil domain containing 65 2 2
MIRT620463 CENPN centromere protein N 2 2
MIRT620909 MUT methylmalonyl-CoA mutase 2 2
MIRT621006 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT621568 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622059 SSBP2 single stranded DNA binding protein 2 2 2
MIRT622132 SP4 Sp4 transcription factor 2 2
MIRT623365 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT624370 CDK12 cyclin dependent kinase 12 2 2
MIRT627944 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT628228 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT630150 ZDHHC9 zinc finger DHHC-type containing 9 2 2
MIRT630237 SORD sorbitol dehydrogenase 2 2
MIRT631271 CENPM centromere protein M 2 2
MIRT637456 ZNF324B zinc finger protein 324B 2 2
MIRT637899 SLC19A3 solute carrier family 19 member 3 2 2
MIRT641610 CAPN7 calpain 7 2 2
MIRT643088 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT643813 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT643911 TCEB2 elongin B 2 2
MIRT644900 ZBED1 zinc finger BED-type containing 1 2 2
MIRT645012 NGRN neugrin, neurite outgrowth associated 2 2
MIRT645521 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT646032 S100A7A S100 calcium binding protein A7A 2 2
MIRT646626 CENPL centromere protein L 2 2
MIRT646721 RHOG ras homolog family member G 2 2
MIRT647196 ZNF583 zinc finger protein 583 2 2
MIRT648010 ZNF431 zinc finger protein 431 2 2
MIRT648362 AKIP1 A-kinase interacting protein 1 2 2
MIRT648400 WRN Werner syndrome RecQ like helicase 2 2
MIRT648833 C8orf37 chromosome 8 open reading frame 37 2 2
MIRT651870 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT652490 TMEM178B transmembrane protein 178B 2 2
MIRT652529 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT652536 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT652795 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT653379 SMAD1 SMAD family member 1 2 2
MIRT655568 P2RX7 purinergic receptor P2X 7 2 2
MIRT657235 IER5 immediate early response 5 2 2
MIRT657594 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658037 FZD9 frizzled class receptor 9 2 2
MIRT658151 FGF10 fibroblast growth factor 10 2 2
MIRT658459 FAM117B family with sequence similarity 117 member B 2 2
MIRT658503 EXOC5 exocyst complex component 5 2 2
MIRT659420 COL4A4 collagen type IV alpha 4 chain 2 2
MIRT660023 C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2 2
MIRT660032 C16orf52 chromosome 16 open reading frame 52 2 2
MIRT661206 MPPE1 metallophosphoesterase 1 2 2
MIRT661639 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT665303 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT668010 HCFC2 host cell factor C2 2 2
MIRT673436 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673583 KDELC2 KDEL motif containing 2 2 2
MIRT673717 SLU7 SLU7 homolog, splicing factor 2 2
MIRT674315 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT675811 MED28 mediator complex subunit 28 2 2
MIRT686564 TPM3 tropomyosin 3 2 2
MIRT687134 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT687463 NKD1 naked cuticle homolog 1 2 2
MIRT690226 C5orf45 MRN complex interacting protein 2 2
MIRT690532 ZNF566 zinc finger protein 566 2 2
MIRT693077 AS3MT arsenite methyltransferase 2 2
MIRT694083 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT695388 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT695638 SLC26A2 solute carrier family 26 member 2 2 2
MIRT696540 C3 complement C3 2 2
MIRT705522 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 2
MIRT711304 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711513 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711617 LHX5 LIM homeobox 5 2 2
MIRT711647 LIPG lipase G, endothelial type 2 2
MIRT711771 CCDC59 coiled-coil domain containing 59 2 2
MIRT713207 SOCS6 suppressor of cytokine signaling 6 2 2
MIRT715047 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT715620 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT717677 CDC42BPA CDC42 binding protein kinase alpha 2 2
MIRT718016 METTL15 methyltransferase like 15 2 2
MIRT721251 KIAA0922 transmembrane 131 like 2 2
MIRT721438 ARPC4 actin related protein 2/3 complex subunit 4 2 2
MIRT722193 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT723319 PRKCH protein kinase C eta 2 2
MIRT725299 NLRC5 NLR family CARD domain containing 5 2 2
MIRT731866 HDAC8 histone deacetylase 8 3 1
MIRT731987 PARP1 poly(ADP-ribose) polymerase 1 3 1
MIRT735558 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 3 0
MIRT735826 SMAD3 SMAD family member 3 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216b Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-216b 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-216b Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Quantitative real-time PCR human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miR-216b Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216b Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-216b Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-216b-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216b-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216b-5p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (SKOV3)
hsa-miR-216b-5p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HT-29, HCT8)
hsa-miR-216b-5p Vemurafenib 42611257 NSC761431 approved sensitive Low Melanoma cell line (A375, G-361)
hsa-miR-216b-5p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-216b-5p Paclitaxel 36314 NSC125973 approved sensitive Low Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-216b-5p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-216b-5p Cetuximab + Folfox(Fluorouracil + Leucovorin + Oxaliplatin) resistant High Metastatic Colorectal Cancer tissue
hsa-miR-216b-5p Carboplatin 38904 NSC241240 approved resistant Low Non-Small Cell Lung Cancer cell line (A549, NCI-H460)
hsa-miR-216b-5p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549, NCI-H460)
hsa-miR-216b-5p Cisplatin 5460033 NSC119875 approved sensitive Low Osteosarcoma cell line (MG-63, SaOS-2)
hsa-miR-216b-5p Paclitaxel 36314 NSC125973 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-miR-216b-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-216b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-216b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-216b-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-216b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-216b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-216b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-216b-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216b-5p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-216b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-216b-5p Cetuximab resistant tissue (colorectal carcinoma)

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