miRTarBase - #MIRT535197


—
pre-miRNA Information
pre-miRNA hsa-mir-4778   
Genomic Coordinates chr2: 66358249 - 66358328
Description Homo sapiens miR-4778 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4778-3p
Sequence 51| UCUUCUUCCUUUGCAGAGUUGA |72
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs936001904 2 dbSNP
rs925922703 3 dbSNP
rs184768286 8 dbSNP
rs1249073833 10 dbSNP
rs977504360 13 dbSNP
rs192300002 18 dbSNP
Putative Targets

Gene Information
Gene Symbol PLCL1   
Synonyms PLCE, PLCL, PLDL1, PPP1R127, PRIP
Description phospholipase C like 1 (inactive)
Transcript NM_006226   
Expression
Putative miRNA Targets on PLCL1
3'UTR of PLCL1
(miRNA target sites are highlighted)		 
>PLCL1|NM_006226|3'UTR
   1 CTCTGGGCATTATCGACACGTTCACCCATCTTATCAAGGACTCTGGTTTCTCATTCTTGTTTTCTTTCTTTAAATGTTTT
  81 ATAAGTTCACAAAATGGTGCCCTATATGGGGTATTGGACATAGATATTTTCACAATGTCAGTATTTCAGTGTAGTTAATT
 161 TATCTAAATTAAAGCCTTTAGTATCAGTGTTTTAAATTCTGAGACATGTGTCAACACCCCTGTGTGGATGCCTGTGGAAG
 241 AGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGCAGAGAGAGAGAAAGAGAGAGAGAGAGAGAAATTCTGTTAAAATCTA
 321 TTCTGTGTTGCATTATTCATTTAGTGAGTTATTCCTTGATCATTTTGGGACAATTGTTTTAATCTGAAATTCTAAAGAGC
 401 ACTTACTGTAACCTGTTGCTGTGTTTAATTTGACTTCTCTGCCTTTGACATTTAATTTAGTGATCTTAGCATAGCTTATT
 481 ATTGAAGGAAGCCAAATTTATCAAAGCATAGATGTTTTGGTAGATTAAATATAGATTAGAAAAATTCCTAAGAATCAGAG
 561 TAGAAATAAAAGTGAATGAAAGATTAAACAGATGATGAGAATTTCTAAAAAGATTAGCAAGGTCATTTCTTCAGTCAGAA
 641 AACTTTAAAAAATATTTATTAAATAAAATCAATTTTTAGGAAGTTTTCTGTAGTCATTTACTAAACATATGATTTCACTA
 721 GAAAAGCTGATCATAAGTGAATTTATACCTACCTGTGTGGTACTCTGAAACACACTGAAAGCTCTGTTGCAATTAGGATT
 801 TTGATGTGACAATAATATTGTTGTATAATTTCGAGATTTGTAGGAAGGTCTCATTCTTCCAAGCTGAGAGTCTAGCACTC
 881 ATTTTCTATAACAGATATGGCAGCTTAGAGGTGTTGGCTTTGTTTGGATGTAATTTAGGGTACTAAATTTAAATTTAAAG
 961 ATATTGTTCAAACAATATCATATCATCACATTGAGCTGATATAAATTCTGTGGGTCCGATAATATCTTTGTGATAATTTA
1041 AGAGCTAACCAGTTACCACACATCTATGATATAACCCTAACACACACAGAAAAGCATACATGCAAAAAGAAATGACTAAT
1121 TAGGGTACATTTATAATTGCATCTAGGTAATTTTTACCCTAATGTCTTCATAAAGTACTTGAGTGTAATGTTTGTTACCT
1201 CCAACAGAACTAAATGTTCTATGGTTATGAAAGAATATATTTATTTAAAGCATTGCTTTTATTTTGAAAAGCTTCTTAAT
1281 TAATTTGATTAACAAATATGCTAATTTGGGGAAACCTAGAGAAGATAATTGTTGAAATTTTGCAAATATAAACATCTCCT
1361 ATAGCTTCTGTGTTATTTCTGACTTCTTAACACTATTATGTTTATGTTGCACATTACTGAAAGAGTAAAGATATGAAAAA
1441 AACACTTATTGTTTTCTTTTATTGTGAATTGAAAAAGCAAAGCTAATGAAAATGGGTTACTACATCAAAAATATCTTAAA
1521 GAGTTTGCTATTTCCATGGACCAGATATGATGAAATTATTCCCTGGGTTTAAAACTGGGCACTCGAGGAGGAGGTACCTG
1601 AAGTCATTTGAAGGCAAGTTTCCAATGATGCTACAATGGCCTGAAAAAATTTCTTTACCCTCTGTTATATTTAACTTGCT
1681 GGTAGGAGGAATAGTGGAATGCAGGTGTTAAGCCCTTTGTGGTGAAAAAGAGGTTCTATAGACAGAAACAAAACCCACCT
1761 TACATCAGCTGATTGGTTGATTTTACTAGTGTACCTCTTCATCTACTTGAATTCTATTTGGTAAATCCATGTCTTTACTG
1841 GATATACAGTTAGGTGGGAAGAGGAGATAAAGGATGACAAACTCTCAAACAATATTTATACATTTATTTACTCCAGGGTC
1921 AAATCCAATCCTTGGAAGTAGCTTCTCTAGTTTATTTTATTTGTCCCAGAGCTCTACTCACACTTAGGACCCACCCAAAA
2001 ATTCTCAAAAACGTAATATGGATTCTGCCTCATCTGATGCTATTTCTGGCAGTGGGTTGTCAGCCATACTCTGCTTCATT
2081 CCACTGGGTGTCCTTGCTAGATGGGGAGTGAGATGTGGAGCAGGGAGGAGCTTTGGATTCTGGGAGTGGAGGTGGCAAGG
2161 GAAAAGTCTCCTAGTCTCCTGTGATGTTCCTGCCTCCAGATAGAATAGCAAAAACAAACAATTTTTTTTTGTGTATTATG
2241 CCTCCATGACATTGTTACATTCTATGAGGAGCATCTGTCTCCTTTCTAGACTTGAACTGTGGTAGAAAAAGCCCCCTTCT
2321 CTCTTCTATCTACTTAGATTTGGTGATGCTAGGAATGTAGTGTTTTAGATATTAATTCTATTTTTATTTATTCATTTTTA
2401 CATCACCAATAGGATCTGAGGTGGAGATGGCGGGTATTATCACTGGCATTTTACAGGTGAGAAAGCCCAAAGCCACTGAG
2481 GTAATTAATGGAATAATTGATTTTGAACTTGGGTCTGTCTGATTTCATGTGCAAGATTATATACTTAGTGATTTTGATTT
2561 TAAGTTTATTCTTAACATTTTAAACCAGACTATTAACTCTTACCTTTATAACCACAGATACAAAGAACTGTATCATTTAT
2641 TTTCTGAATATAAAATATTAATGGTCAATATAAAAATACAAAAATAGAGAACTATATACAACAGAAAAGCAAAATTACCC
2721 ACTAATAACATTTTGATTTATATCCCTTTAGACACTGTTTAGAGTTTATACATATATGTAAATATGCTTGTATTTTAACA
2801 AAATTGAGATATTATATAAACTGTTTGTAGCAGGGTGTTTAAAATTTTAACAATATGTTATGGATATCTTTCTGTGTCAA
2881 TAAATGTGTATTTACATTAGAGTTCCAAGCATTTGAACTGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUUGAGACGU---UUCCUUCUUCu 5'
            ||||  |||   :||||:||:| 
Target 5' aaAACTGGGCACTCGAGGAGGAGGt 3'
 1571 - 1595 136.00 -18.60
2 
miRNA  3' agUUGAGACGUUUCCUUCUUCu 5'
            |::|  |:  :||||||:| 
Target 5' acAGTTAGGT--GGGAAGAGGa 3'
 1846 - 1865 132.00 -17.70
3 
miRNA  3' agUUGAGACG--UUUCCUUCUUcu 5'
            |||| |||  : ||||:|||  
Target 5' ttAACT-TGCTGGTAGGAGGAAta 3'
 1671 - 1693 129.00 -13.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13961504 5 COSMIC
COSN13961505 15 COSMIC
COSN31481559 20 COSMIC
COSN13961506 21 COSMIC
COSN30456870 27 COSMIC
COSN31482586 31 COSMIC
COSN30471263 35 COSMIC
COSN30527077 45 COSMIC
COSN31498449 47 COSMIC
COSN30623229 50 COSMIC
COSN30130444 57 COSMIC
COSN31574535 85 COSMIC
COSN20074305 101 COSMIC
COSN30162014 105 COSMIC
COSN30108279 110 COSMIC
COSN31569622 124 COSMIC
COSN26584522 133 COSMIC
COSN24309235 142 COSMIC
COSN31556021 149 COSMIC
COSN31529435 161 COSMIC
COSN31486316 186 COSMIC
COSN26548667 188 COSMIC
COSN20097631 273 COSMIC
COSN27489631 273 COSMIC
COSN31585389 289 COSMIC
COSN8277027 499 COSMIC
COSN28201564 520 COSMIC
COSN30381079 567 COSMIC
COSN6163219 678 COSMIC
COSN9302744 710 COSMIC
COSN21720400 738 COSMIC
COSN25158508 754 COSMIC
COSN6680100 811 COSMIC
COSN1817581 843 COSMIC
COSN9871087 847 COSMIC
COSN26725084 902 COSMIC
COSN23580406 1153 COSMIC
COSN19524918 1173 COSMIC
COSN29868951 1214 COSMIC
COSN23739715 1257 COSMIC
COSN16755536 1353 COSMIC
COSN16625476 1478 COSMIC
COSN24820483 1490 COSMIC
COSN25321124 1490 COSMIC
COSN26720867 1510 COSMIC
COSN25977188 1542 COSMIC
COSN7156590 1555 COSMIC
COSN21949256 1586 COSMIC
COSN1817582 1618 COSMIC
COSN1817583 1867 COSMIC
COSN22658185 2026 COSMIC
COSN29050707 2063 COSMIC
COSN15668458 2492 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1475339118 2 dbSNP
rs769375247 3 dbSNP
rs1437070022 5 dbSNP
rs1222063122 12 dbSNP
rs1248203582 13 dbSNP
rs199693790 15 dbSNP
rs764023079 16 dbSNP
rs371450109 20 dbSNP
rs374739063 21 dbSNP
rs1281882345 27 dbSNP
rs1478496909 28 dbSNP
rs767387425 29 dbSNP
rs772378301 30 dbSNP
rs1366825368 31 dbSNP
rs370110034 34 dbSNP
rs756204637 36 dbSNP
rs570729653 37 dbSNP
rs1018823906 39 dbSNP
rs962276589 40 dbSNP
rs1159981282 50 dbSNP
rs778311884 53 dbSNP
rs1428365133 64 dbSNP
rs1197139646 66 dbSNP
rs1270491886 77 dbSNP
rs1481378595 80 dbSNP
rs117274739 81 dbSNP
rs143479265 82 dbSNP
rs1445414229 93 dbSNP
rs1364053334 95 dbSNP
rs780927523 100 dbSNP
rs1051380495 105 dbSNP
rs183191671 106 dbSNP
rs1225830913 110 dbSNP
rs535250832 111 dbSNP
rs566396561 115 dbSNP
rs1270197847 116 dbSNP
rs948198449 117 dbSNP
rs1429377509 121 dbSNP
rs1324224425 134 dbSNP
rs771594853 142 dbSNP
rs928191081 143 dbSNP
rs1039801008 150 dbSNP
rs898586651 155 dbSNP
rs935581847 160 dbSNP
rs1052727583 163 dbSNP
rs1470865449 167 dbSNP
rs1425777095 169 dbSNP
rs775259131 170 dbSNP
rs760451508 175 dbSNP
rs1474452875 176 dbSNP
rs1010590394 187 dbSNP
rs1243952110 193 dbSNP
rs1189385299 198 dbSNP
rs187604715 200 dbSNP
rs887000787 206 dbSNP
rs1205964450 209 dbSNP
rs1313196494 216 dbSNP
rs1272895816 219 dbSNP
rs1050150787 220 dbSNP
rs1301554710 227 dbSNP
rs1329741985 228 dbSNP
rs150952998 232 dbSNP
rs1444033387 237 dbSNP
rs1274668529 238 dbSNP
rs1354921609 239 dbSNP
rs1242928111 240 dbSNP
rs1228485858 242 dbSNP
rs1276046461 242 dbSNP
rs1358153576 242 dbSNP
rs1440070959 242 dbSNP
rs147019933 242 dbSNP
rs1491158220 242 dbSNP
rs55930007 242 dbSNP
rs958361557 242 dbSNP
rs1491310071 243 dbSNP
rs1312428423 244 dbSNP
rs1349863016 247 dbSNP
rs1379545608 257 dbSNP
rs1439829012 263 dbSNP
rs1246669979 264 dbSNP
rs1356206820 266 dbSNP
rs1308602644 269 dbSNP
rs1424074659 269 dbSNP
rs1363815690 272 dbSNP
rs766027512 272 dbSNP
rs1008701284 274 dbSNP
rs1293291231 274 dbSNP
rs1204043509 275 dbSNP
rs1471398717 275 dbSNP
rs1267543291 276 dbSNP
rs1253124378 278 dbSNP
rs1221105332 279 dbSNP
rs1019185671 281 dbSNP
rs1250723509 283 dbSNP
rs1012545255 287 dbSNP
rs1223241689 287 dbSNP
rs1467654332 287 dbSNP
rs149667225 287 dbSNP
rs1221830131 288 dbSNP
rs897695814 295 dbSNP
rs544205908 297 dbSNP
rs1288855081 309 dbSNP
rs1404291280 311 dbSNP
rs979598248 318 dbSNP
rs1295375896 320 dbSNP
rs77466253 331 dbSNP
rs1157242994 344 dbSNP
rs1402779510 348 dbSNP
rs1445742060 362 dbSNP
rs1413184750 366 dbSNP
rs1199272638 368 dbSNP
rs373934769 370 dbSNP
rs776486307 376 dbSNP
rs112586983 377 dbSNP
rs952684196 384 dbSNP
rs577480669 389 dbSNP
rs984101929 396 dbSNP
rs1488546444 399 dbSNP
rs1259760956 400 dbSNP
rs1023634242 403 dbSNP
rs987459186 413 dbSNP
rs1268531868 416 dbSNP
rs1222759162 419 dbSNP
rs1168581766 423 dbSNP
rs1303404023 434 dbSNP
rs969438975 438 dbSNP
rs1387394173 441 dbSNP
rs1398889692 450 dbSNP
rs140931936 451 dbSNP
rs942641189 453 dbSNP
rs982260167 458 dbSNP
rs1375936536 466 dbSNP
rs1389774358 468 dbSNP
rs1176148419 478 dbSNP
rs560066289 488 dbSNP
rs1468633487 491 dbSNP
rs1449634637 496 dbSNP
rs528742774 498 dbSNP
rs928105927 501 dbSNP
rs1177487918 503 dbSNP
rs1433214419 520 dbSNP
rs1453129709 524 dbSNP
rs1316995178 526 dbSNP
rs1184337434 532 dbSNP
rs192594987 533 dbSNP
rs1248317379 543 dbSNP
rs935544870 547 dbSNP
rs1321203363 548 dbSNP
rs7349300 549 dbSNP
rs1243421435 553 dbSNP
rs1251455283 559 dbSNP
rs1306948143 561 dbSNP
rs1293526319 569 dbSNP
rs144601834 577 dbSNP
rs1366198280 587 dbSNP
rs1336372598 588 dbSNP
rs1450887775 591 dbSNP
rs915516245 597 dbSNP
rs530864074 600 dbSNP
rs550975225 618 dbSNP
rs1461926895 625 dbSNP
rs1462016395 627 dbSNP
rs1371939736 633 dbSNP
rs1166155868 634 dbSNP
rs1050096218 639 dbSNP
rs1450863737 649 dbSNP
rs1390370718 650 dbSNP
rs1182648821 656 dbSNP
rs888818268 674 dbSNP
rs1047170814 691 dbSNP
rs944435580 691 dbSNP
rs1200895922 702 dbSNP
rs1040146873 708 dbSNP
rs1249615731 738 dbSNP
rs1193982708 758 dbSNP
rs897639000 776 dbSNP
rs993356222 787 dbSNP
rs1474535501 797 dbSNP
rs1342570128 809 dbSNP
rs377388965 810 dbSNP
rs1313902517 811 dbSNP
rs1167503823 812 dbSNP
rs1394959152 820 dbSNP
rs1310429124 821 dbSNP
rs1407122817 823 dbSNP
rs779535723 833 dbSNP
rs887695478 834 dbSNP
rs1162486296 837 dbSNP
rs761751457 863 dbSNP
rs1369919080 869 dbSNP
rs766432782 872 dbSNP
rs1418329096 876 dbSNP
rs969386568 880 dbSNP
rs1248305828 889 dbSNP
rs751620288 897 dbSNP
rs1483400857 911 dbSNP
rs748837053 935 dbSNP
rs1035125942 941 dbSNP
rs1220462945 952 dbSNP
rs1327629406 958 dbSNP
rs1358724680 962 dbSNP
rs1266327039 967 dbSNP
rs957068830 969 dbSNP
rs988330950 976 dbSNP
rs1290700726 981 dbSNP
rs915462359 990 dbSNP
rs1350492136 995 dbSNP
rs570723141 1003 dbSNP
rs946943167 1012 dbSNP
rs1302000371 1013 dbSNP
rs539805539 1017 dbSNP
rs546609831 1018 dbSNP
rs910200489 1019 dbSNP
rs767608598 1023 dbSNP
rs1483189226 1024 dbSNP
rs1031462004 1026 dbSNP
rs1472886484 1027 dbSNP
rs752613386 1033 dbSNP
rs1040496915 1038 dbSNP
rs75551379 1040 dbSNP
rs964306624 1051 dbSNP
rs929090088 1052 dbSNP
rs1430231823 1063 dbSNP
rs1348931646 1067 dbSNP
rs1270416179 1073 dbSNP
rs919911865 1074 dbSNP
rs1481582334 1076 dbSNP
rs1178290248 1082 dbSNP
rs931353142 1084 dbSNP
rs1323431231 1088 dbSNP
rs983268859 1089 dbSNP
rs908658294 1091 dbSNP
rs756538608 1095 dbSNP
rs938474846 1097 dbSNP
rs535308739 1102 dbSNP
rs887652865 1106 dbSNP
rs1465379032 1113 dbSNP
rs894369389 1114 dbSNP
rs1428475382 1117 dbSNP
rs1012770553 1121 dbSNP
rs1170797844 1122 dbSNP
rs1044320279 1125 dbSNP
rs1247396261 1126 dbSNP
rs948627635 1128 dbSNP
rs1042978450 1129 dbSNP
rs555104389 1131 dbSNP
rs1387056272 1140 dbSNP
rs1209742836 1147 dbSNP
rs138546507 1152 dbSNP
rs1277068267 1158 dbSNP
rs1221468282 1159 dbSNP
rs1461016138 1163 dbSNP
rs778284007 1165 dbSNP
rs905175268 1174 dbSNP
rs904197506 1176 dbSNP
rs1345746819 1190 dbSNP
rs998567585 1199 dbSNP
rs1435515427 1208 dbSNP
rs1031801592 1212 dbSNP
rs1332065232 1213 dbSNP
rs1416101998 1215 dbSNP
rs1425886545 1220 dbSNP
rs890212491 1222 dbSNP
rs1167391621 1225 dbSNP
rs1003565417 1234 dbSNP
rs1392234591 1238 dbSNP
rs1225004643 1246 dbSNP
rs537507897 1251 dbSNP
rs1019805886 1256 dbSNP
rs956820056 1257 dbSNP
rs1311923188 1261 dbSNP
rs1273005605 1272 dbSNP
rs1203774461 1279 dbSNP
rs975642313 1283 dbSNP
rs1299293998 1288 dbSNP
rs1240244753 1296 dbSNP
rs1010100006 1299 dbSNP
rs1282223274 1301 dbSNP
rs796270395 1302 dbSNP
rs952814570 1303 dbSNP
rs1215986283 1305 dbSNP
rs1427849692 1307 dbSNP
rs756334527 1312 dbSNP
rs1022468933 1317 dbSNP
rs908596961 1320 dbSNP
rs1444251058 1322 dbSNP
rs557815411 1329 dbSNP
rs938794142 1338 dbSNP
rs28513170 1349 dbSNP
rs915727881 1354 dbSNP
rs948596658 1361 dbSNP
rs1180675818 1365 dbSNP
rs1481763163 1369 dbSNP
rs540220477 1369 dbSNP
rs910819303 1372 dbSNP
rs1276161296 1373 dbSNP
rs1159578436 1378 dbSNP
rs1323897687 1384 dbSNP
rs115999478 1385 dbSNP
rs1320725802 1388 dbSNP
rs975775697 1396 dbSNP
rs1229785902 1413 dbSNP
rs72914797 1414 dbSNP
rs1365708314 1419 dbSNP
rs1287606924 1426 dbSNP
rs1407930159 1431 dbSNP
rs1308702405 1436 dbSNP
rs1352355969 1436 dbSNP
rs934278535 1436 dbSNP
rs1052804006 1437 dbSNP
rs1167235930 1443 dbSNP
rs1300853991 1446 dbSNP
rs542444227 1446 dbSNP
rs1157499901 1449 dbSNP
rs1366470628 1449 dbSNP
rs370281944 1450 dbSNP
rs1392322751 1453 dbSNP
rs1048822218 1462 dbSNP
rs1253235140 1473 dbSNP
rs909039434 1478 dbSNP
rs774076801 1490 dbSNP
rs757740335 1493 dbSNP
rs779516424 1500 dbSNP
rs1008632972 1502 dbSNP
rs948570429 1505 dbSNP
rs1038824575 1510 dbSNP
rs1044269192 1514 dbSNP
rs1226410106 1531 dbSNP
rs562239047 1536 dbSNP
rs907121893 1538 dbSNP
rs1288955839 1545 dbSNP
rs1386263154 1576 dbSNP
rs1361629363 1578 dbSNP
rs997050545 1581 dbSNP
rs1295465649 1582 dbSNP
rs1027205925 1586 dbSNP
rs1344917362 1588 dbSNP
rs1157373483 1600 dbSNP
rs531050318 1606 dbSNP
rs1003921266 1617 dbSNP
rs1056461030 1626 dbSNP
rs1176393971 1629 dbSNP
rs745351190 1633 dbSNP
rs1422454733 1638 dbSNP
rs1004592828 1640 dbSNP
rs531967235 1641 dbSNP
rs544414213 1650 dbSNP
rs187416232 1654 dbSNP
rs1009635145 1657 dbSNP
rs1268635873 1679 dbSNP
rs1022415532 1682 dbSNP
rs533220670 1683 dbSNP
rs1177875111 1690 dbSNP
rs546582478 1695 dbSNP
rs1385819046 1708 dbSNP
rs1219947944 1710 dbSNP
rs1425929076 1713 dbSNP
rs771671108 1714 dbSNP
rs566441372 1715 dbSNP
rs1437694459 1719 dbSNP
rs1462217912 1733 dbSNP
rs1017830299 1734 dbSNP
rs1389865872 1741 dbSNP
rs1300247157 1743 dbSNP
rs1371568863 1749 dbSNP
rs1302711985 1758 dbSNP
rs529108068 1759 dbSNP
rs1464996881 1765 dbSNP
rs113362575 1782 dbSNP
rs1316267278 1784 dbSNP
rs1433309981 1790 dbSNP
rs1389148441 1792 dbSNP
rs1186309218 1794 dbSNP
rs976772898 1795 dbSNP
rs1385639986 1800 dbSNP
rs1248412129 1802 dbSNP
rs978565709 1803 dbSNP
rs925837642 1804 dbSNP
rs1257757320 1809 dbSNP
rs779679180 1817 dbSNP
rs1341605429 1828 dbSNP
rs1295612399 1845 dbSNP
rs950466820 1846 dbSNP
rs1366309200 1847 dbSNP
rs548780589 1854 dbSNP
rs1289327404 1874 dbSNP
rs143679893 1879 dbSNP
rs34461747 1879 dbSNP
rs796172354 1879 dbSNP
rs908986863 1887 dbSNP
rs746670006 1894 dbSNP
rs768382249 1903 dbSNP
rs192891663 1907 dbSNP
rs1369436900 1917 dbSNP
rs948518358 1918 dbSNP
rs1038793543 1923 dbSNP
rs1456245299 1927 dbSNP
rs1186566946 1929 dbSNP
rs1421877396 1932 dbSNP
rs1044217664 1935 dbSNP
rs570573897 1939 dbSNP
rs938610066 1978 dbSNP
rs1446446235 1980 dbSNP
rs866500307 1984 dbSNP
rs892453116 1986 dbSNP
rs1207456157 1988 dbSNP
rs1343135821 1992 dbSNP
rs1265125652 2005 dbSNP
rs1243048135 2012 dbSNP
rs537534762 2013 dbSNP
rs1016301189 2014 dbSNP
rs1172034932 2026 dbSNP
rs1043809211 2029 dbSNP
rs138257500 2031 dbSNP
rs1305623511 2032 dbSNP
rs903940265 2038 dbSNP
rs1396731662 2046 dbSNP
rs1162333405 2050 dbSNP
rs1007696918 2052 dbSNP
rs1456152088 2057 dbSNP
rs1370008091 2062 dbSNP
rs1014218708 2065 dbSNP
rs1249614218 2074 dbSNP
rs1184399735 2076 dbSNP
rs1483453470 2078 dbSNP
rs1266888752 2079 dbSNP
rs1208323188 2085 dbSNP
rs184958178 2093 dbSNP
rs902047345 2094 dbSNP
rs1408934392 2109 dbSNP
rs997767351 2115 dbSNP
rs1228224894 2117 dbSNP
rs1026997403 2119 dbSNP
rs1451144939 2126 dbSNP
rs970131686 2143 dbSNP
rs978534580 2144 dbSNP
rs761698221 2150 dbSNP
rs1322419370 2174 dbSNP
rs956089073 2178 dbSNP
rs1392510707 2179 dbSNP
rs571310548 2187 dbSNP
rs1288140968 2188 dbSNP
rs1317532386 2189 dbSNP
rs544838246 2197 dbSNP
rs1409632753 2198 dbSNP
rs969771550 2206 dbSNP
rs1263576511 2207 dbSNP
rs145910302 2212 dbSNP
rs373411043 2212 dbSNP
rs1207879526 2218 dbSNP
rs1470532334 2219 dbSNP
rs1377146833 2221 dbSNP
rs1236867958 2222 dbSNP
rs533561237 2222 dbSNP
rs988741443 2222 dbSNP
rs1253935787 2227 dbSNP
rs563046375 2230 dbSNP
rs1187780011 2245 dbSNP
rs1463860775 2252 dbSNP
rs1270523887 2259 dbSNP
rs928470535 2263 dbSNP
rs1350680827 2264 dbSNP
rs1421007394 2265 dbSNP
rs1477328836 2270 dbSNP
rs944320496 2272 dbSNP
rs1332433328 2276 dbSNP
rs938541763 2285 dbSNP
rs988715618 2293 dbSNP
rs867412177 2307 dbSNP
rs1434030952 2312 dbSNP
rs1386227744 2313 dbSNP
rs1431963997 2324 dbSNP
rs1322388236 2329 dbSNP
rs945318327 2338 dbSNP
rs553754409 2346 dbSNP
rs1413143829 2347 dbSNP
rs1043751465 2349 dbSNP
rs903888068 2359 dbSNP
rs1479068999 2362 dbSNP
rs1346308635 2363 dbSNP
rs1432903223 2376 dbSNP
rs1287245993 2379 dbSNP
rs1188190491 2394 dbSNP
rs1448002444 2403 dbSNP
rs921651687 2405 dbSNP
rs930367736 2407 dbSNP
rs943429448 2410 dbSNP
rs1049308896 2413 dbSNP
rs1198208102 2432 dbSNP
rs773249259 2433 dbSNP
rs901983223 2435 dbSNP
rs1227224408 2466 dbSNP
rs1362701071 2477 dbSNP
rs573603016 2506 dbSNP
rs1224409295 2513 dbSNP
rs998113572 2518 dbSNP
rs748391986 2519 dbSNP
rs772498121 2522 dbSNP
rs542507737 2528 dbSNP
rs1332166343 2533 dbSNP
rs1026530330 2537 dbSNP
rs896077562 2540 dbSNP
rs1376175938 2541 dbSNP
rs886700630 2552 dbSNP
rs1014184069 2557 dbSNP
rs1428078598 2558 dbSNP
rs1392331750 2560 dbSNP
rs1187442240 2578 dbSNP
rs556080114 2582 dbSNP
rs1325373109 2587 dbSNP
rs1217268746 2589 dbSNP
rs1022932084 2591 dbSNP
rs1317509174 2599 dbSNP
rs1006462768 2609 dbSNP
rs1486331403 2610 dbSNP
rs74265555 2613 dbSNP
rs189367071 2614 dbSNP
rs1000216688 2620 dbSNP
rs1339625058 2622 dbSNP
rs1217309023 2631 dbSNP
rs1260459897 2633 dbSNP
rs1355401736 2635 dbSNP
rs1282317347 2641 dbSNP
rs1487744247 2651 dbSNP
rs1033549799 2685 dbSNP
rs955890350 2690 dbSNP
rs13018895 2696 dbSNP
rs1408123971 2699 dbSNP
rs544790821 2703 dbSNP
rs1171423252 2719 dbSNP
rs1412087835 2720 dbSNP
rs1018823782 2726 dbSNP
rs13019036 2732 dbSNP
rs974686508 2733 dbSNP
rs921581181 2735 dbSNP
rs930336706 2747 dbSNP
rs984551218 2752 dbSNP
rs1035859370 2754 dbSNP
rs1409333449 2755 dbSNP
rs1450757120 2761 dbSNP
rs1287483941 2763 dbSNP
rs775783911 2766 dbSNP
rs533427217 2772 dbSNP
rs149619136 2774 dbSNP
rs1226598862 2784 dbSNP
rs535405013 2785 dbSNP
rs1156911005 2787 dbSNP
rs940167030 2794 dbSNP
rs1436049628 2795 dbSNP
rs1405665441 2805 dbSNP
rs1348416606 2809 dbSNP
rs1305117317 2816 dbSNP
rs554538663 2821 dbSNP
rs181017087 2831 dbSNP
rs1462329275 2836 dbSNP
rs1037627251 2837 dbSNP
rs377584797 2838 dbSNP
rs1471299831 2840 dbSNP
rs913112249 2844 dbSNP
rs868397161 2846 dbSNP
rs978712450 2851 dbSNP
rs1177367554 2853 dbSNP
rs950287487 2855 dbSNP
rs1373924540 2858 dbSNP
rs925253804 2858 dbSNP
rs1044650507 2863 dbSNP
rs572754071 2869 dbSNP
rs770953046 2873 dbSNP
rs1206749186 2876 dbSNP
rs1039095914 2879 dbSNP
rs1307784525 2881 dbSNP
rs1218794770 2883 dbSNP
rs1365723222 2895 dbSNP
rs1313383762 2896 dbSNP
rs1033063373 2897 dbSNP
rs923354543 2899 dbSNP
rs1388400368 2900 dbSNP
rs761004636 2901 dbSNP
rs1319051375 2902 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 5334.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000428675.1 | 3UTR | AGAAGAAAUUAAAAAGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
169 hsa-miR-4778-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT199338 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 4
MIRT203028 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT260646 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT336468 SRP9 signal recognition particle 9 2 2
MIRT389212 SERTAD2 SERTA domain containing 2 2 2
MIRT441814 TENM1 teneurin transmembrane protein 1 2 2
MIRT444029 GREM1 gremlin 1, DAN family BMP antagonist 2 4
MIRT454171 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT469663 RABEPK Rab9 effector protein with kelch motifs 2 2
MIRT495579 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT498340 PRELID2 PRELI domain containing 2 2 2
MIRT498696 LYRM2 LYR motif containing 2 2 6
MIRT504156 OPN5 opsin 5 2 4
MIRT506321 OTUD4 OTU deubiquitinase 4 2 4
MIRT507608 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT525431 PROX2 prospero homeobox 2 2 2
MIRT526973 PAX7 paired box 7 2 2
MIRT527814 TMEM74B transmembrane protein 74B 2 2
MIRT527960 MTAP methylthioadenosine phosphorylase 2 2
MIRT528083 NOL9 nucleolar protein 9 2 2
MIRT528480 STAMBPL1 STAM binding protein like 1 2 2
MIRT528947 PNMA5 paraneoplastic Ma antigen family member 5 2 2
MIRT530687 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT531733 SLC2A9 solute carrier family 2 member 9 2 2
MIRT532445 PLGRKT plasminogen receptor with a C-terminal lysine 2 2
MIRT533331 UNK unkempt family zinc finger 2 2
MIRT534205 SLC38A9 solute carrier family 38 member 9 2 2
MIRT534322 SHISA6 shisa family member 6 2 2
MIRT535197 PLCL1 phospholipase C like 1 (inactive) 2 2
MIRT538076 DIAPH2 diaphanous related formin 2 2 2
MIRT539250 ANKRD50 ankyrin repeat domain 50 2 2
MIRT548733 CREBRF CREB3 regulatory factor 2 2
MIRT556406 LRRC8B leucine rich repeat containing 8 VRAC subunit B 2 2
MIRT559576 AP1AR adaptor related protein complex 1 associated regulatory protein 2 2
MIRT567661 ERGIC2 ERGIC and golgi 2 2 2
MIRT572750 FAM204A family with sequence similarity 204 member A 2 2
MIRT609355 ZNF664 zinc finger protein 664 2 2
MIRT611194 TMEM105 transmembrane protein 105 2 2
MIRT611545 BIRC5 baculoviral IAP repeat containing 5 2 4
MIRT611690 NODAL nodal growth differentiation factor 2 2
MIRT611810 FCRL4 Fc receptor like 4 2 2
MIRT612746 MYOCD myocardin 2 2
MIRT614177 FAM53B family with sequence similarity 53 member B 2 2
MIRT614431 TAZ tafazzin 2 2
MIRT614586 SDC1 syndecan 1 2 2
MIRT615547 TNFSF15 TNF superfamily member 15 2 2
MIRT615872 BRD3 bromodomain containing 3 2 2
MIRT615970 ASCL1 achaete-scute family bHLH transcription factor 1 2 2
MIRT616024 PRRG4 proline rich and Gla domain 4 2 4
MIRT616242 NFIC nuclear factor I C 2 2
MIRT616282 HMGB1 high mobility group box 1 2 2
MIRT616674 PRR15 proline rich 15 2 2
MIRT618302 COL4A4 collagen type IV alpha 4 chain 2 2
MIRT618657 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT618754 SLC38A5 solute carrier family 38 member 5 2 2
MIRT619505 TXLNB taxilin beta 2 2
MIRT619545 GABRG2 gamma-aminobutyric acid type A receptor gamma2 subunit 2 2
MIRT619605 MKKS McKusick-Kaufman syndrome 2 2
MIRT619804 CDC42EP4 CDC42 effector protein 4 2 2
MIRT619923 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT620442 SEMA3E semaphorin 3E 2 4
MIRT620730 CCL16 C-C motif chemokine ligand 16 2 2
MIRT625345 TAPBP TAP binding protein 2 2
MIRT627510 ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2 2
MIRT632584 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT636901 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT637873 UTP6 UTP6, small subunit processome component 2 2
MIRT639011 ABI2 abl interactor 2 2 2
MIRT639054 FPR1 formyl peptide receptor 1 2 2
MIRT639085 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639589 RGS5 regulator of G protein signaling 5 2 2
MIRT639718 NPRL3 NPR3 like, GATOR1 complex subunit 2 2
MIRT639904 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT640392 ZNF785 zinc finger protein 785 2 2
MIRT640786 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT641290 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641442 PELO pelota mRNA surveillance and ribosome rescue factor 2 2
MIRT642426 STAT3 signal transducer and activator of transcription 3 2 2
MIRT642682 KRT74 keratin 74 2 2
MIRT643362 TRIM10 tripartite motif containing 10 2 2
MIRT643982 DUSP28 dual specificity phosphatase 28 2 2
MIRT644466 ZNF747 zinc finger protein 747 2 2
MIRT644561 SPOP speckle type BTB/POZ protein 2 2
MIRT645748 FAM213A family with sequence similarity 213 member A 2 2
MIRT646737 FADS1 fatty acid desaturase 1 2 2
MIRT647446 SIX6 SIX homeobox 6 2 2
MIRT648317 SCNN1G sodium channel epithelial 1 gamma subunit 2 2
MIRT649327 POLG DNA polymerase gamma, catalytic subunit 2 2
MIRT649453 WDR70 WD repeat domain 70 2 2
MIRT650066 CCDC134 coiled-coil domain containing 134 2 2
MIRT650156 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT650317 TMX4 thioredoxin related transmembrane protein 4 2 2
MIRT650429 BBS9 Bardet-Biedl syndrome 9 2 2
MIRT651325 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651843 USP13 ubiquitin specific peptidase 13 2 2
MIRT652532 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT652816 TARDBP TAR DNA binding protein 2 2
MIRT652971 SUN2 Sad1 and UNC84 domain containing 2 2 2
MIRT653466 SLC5A12 solute carrier family 5 member 12 2 4
MIRT653568 SLC35B3 solute carrier family 35 member B3 2 2
MIRT655678 NUMBL NUMB like, endocytic adaptor protein 2 2
MIRT656785 KPNA4 karyopherin subunit alpha 4 2 2
MIRT656798 KNTC1 kinetochore associated 1 2 2
MIRT656988 KDM5A lysine demethylase 5A 2 2
MIRT657292 HOXB5 homeobox B5 2 2
MIRT657497 HBEGF heparin binding EGF like growth factor 2 4
MIRT658012 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT658146 STXBP2 syntaxin binding protein 2 2 2
MIRT658259 FAXC failed axon connections homolog 2 2
MIRT659051 DGKH diacylglycerol kinase eta 2 2
MIRT659171 DCTN3 dynactin subunit 3 2 2
MIRT659936 CACHD1 cache domain containing 1 2 2
MIRT660079 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT660167 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660292 BICC1 BicC family RNA binding protein 1 2 2
MIRT660317 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT660340 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT660447 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 2 2
MIRT661634 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662438 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT664202 TBCA tubulin folding cofactor A 2 2
MIRT666436 SH2B3 SH2B adaptor protein 3 2 2
MIRT666666 RBM47 RNA binding motif protein 47 2 4
MIRT669253 C4orf36 chromosome 4 open reading frame 36 2 2
MIRT669502 ARL3 ADP ribosylation factor like GTPase 3 2 2
MIRT693912 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT700435 PURB purine rich element binding protein B 2 2
MIRT702857 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT708857 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709030 KBTBD13 kelch repeat and BTB domain containing 13 2 2
MIRT709609 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT709810 AR androgen receptor 2 2
MIRT709872 A1CF APOBEC1 complementation factor 2 2
MIRT710208 ENAH ENAH, actin regulator 2 2
MIRT710964 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711173 EMCN endomucin 2 2
MIRT711219 RETSAT retinol saturase 2 2
MIRT711345 FMNL2 formin like 2 2 2
MIRT711441 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT711631 PEBP1 phosphatidylethanolamine binding protein 1 2 2
MIRT711823 MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2 2
MIRT712164 SURF4 surfeit 4 2 2
MIRT712632 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713692 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT714906 CHMP3 charged multivesicular body protein 3 2 2
MIRT715161 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT715430 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT715660 ZBTB25 zinc finger and BTB domain containing 25 2 2
MIRT715968 FADS3 fatty acid desaturase 3 2 2
MIRT716203 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716234 SRSF12 serine and arginine rich splicing factor 12 2 2
MIRT716251 PALM2 paralemmin 2 2 2
MIRT716375 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT716490 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT716744 APOL6 apolipoprotein L6 2 2
MIRT717624 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2 2
MIRT718480 TMEM151A transmembrane protein 151A 2 2
MIRT718805 PRKCB protein kinase C beta 2 2
MIRT719276 SETD7 SET domain containing lysine methyltransferase 7 2 2
MIRT719432 NPTX2 neuronal pentraxin 2 2 2
MIRT721011 ZNF619 zinc finger protein 619 2 2
MIRT721819 HEATR5A HEAT repeat containing 5A 2 2
MIRT721997 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT723143 METTL24 methyltransferase like 24 2 2
MIRT723213 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT723427 MC2R melanocortin 2 receptor 2 2
MIRT723436 ADI1 acireductone dioxygenase 1 2 2
MIRT723542 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT724474 MMD monocyte to macrophage differentiation associated 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4778-3p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-4778-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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