pre-miRNA Information | |
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pre-miRNA | hsa-mir-215 |
Genomic Coordinates | chr1: 220117853 - 220117962 |
Synonyms | MIRN215, miRNA215, mir-215, MIR215 |
Description | Homo sapiens miR-215 stem-loop |
Comment | This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences . |
RNA Secondary Structure | |
Associated Diseases |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-215-3p | |||||||||||||||||||||
Sequence | 64| UCUGUCAUUUCUUUAGGCCAAUA |86 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | MAPK14 | ||||||||||||||||||||
Synonyms | CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | ||||||||||||||||||||
Description | mitogen-activated protein kinase 14 | ||||||||||||||||||||
Transcript | NM_139014 | ||||||||||||||||||||
Other Transcripts | NM_139012 , NM_139013 , NM_001315 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on MAPK14 | |||||||||||||||||||||
3'UTR of MAPK14 (miRNA target sites are highlighted) |
>MAPK14|NM_139014|3'UTR 1 ATGAGTGGAAAAGCCTGACCTATGATGAAGTCATCAGCTTTGTGCCACCACCCCTTGACCAAGAAGAGATGGAGTCCTGA 81 GCACCTGGTTTCTGTTCTGTTGATCCCACTTCACTGTGAGGGGAAGGCCTTTTCACGGGAACTCTCCAAATATTATTCAA 161 GTGCCTCTTGTTGCAGAGATTTCCTCCATGGTGGAAGGGGGTGTGCGTGCGTGTGCGTGCGTGTTAGTGTGTGTGCATGT 241 GTGTGTCTGTCTTTGTGGGAGGGTAAGACAATATGAACAAACTATGATCACAGTGACTTTACAGGAGGTTGTGGATGCTC 321 CAGGGCAGCCTCCACCTTGCTCTTCTTTCTGAGAGTTGGCTCAGGCAGACAAGAGCTGCTGTCCTTTTAGGAATATGTTC 401 AATGCAAAGTAAAAAAATATGAATTGTCCCCAATCCCGGTCATGCTTTTGCCACTTTGGCTTCTCCTGTGACCCCACCTT 481 GACGGTGGGGCGTAGACTTGACAACATCCCACAGTGGCACGGAGAGAAGGCCCATACCTTCTGGTTGCTTCAGACCTGAC 561 ACCGTCCCTCAGTGATACGTACAGCCAAAAAGGACCAACTGGCTTCTGTGCACTAGCCTGTGATTAACTTGCTTAGTATG 641 GTTCTCAGATCTTGACAGTATATTTGAAACTGTAAATATGTTTGTGCCTTAAAAGGAGAGAAGAAAGTGTAGATAGTTAA 721 AAGACTGCAGCTGCTGAAGTTCTGAGCCGGGCAAGTCGAGAGGGCTGTTGGACAGCTGCTTGTGGGCCCGGAGTAATCAG 801 GCAGCCTTCATAGGCGGTCATGTGTGCATGTGAGCACATGCGTATATGTGCGTCTCTCTTTCTCCCTCACCCCCAGGTGT 881 TGCCATTTCTCTGCTTACCCTTCACCTTTGGTGCAGAGGTTTCTTGAATATCTGCCCCAGTAGTCAGAAGCAGGTTCTTG 961 ATGTCATGTACTTCCTGTGTACTCTTTATTTCTAGCAGAGTGAGGATGTGTTTTGCACGTCTTGCTATTTGAGCATGCAC 1041 AGCTGCTTGTCCTGCTCTCTTCAGGAGGCCCTGGTGTCAGGCAGGTTTGCCAGTGAAGACTTCTTGGGTAGTTTAGATCC 1121 CATGTCACCTCAGCTGATATTATGGCAAGTGATATCACCTCTCTTCAGCCCCTAGTGCTATTCTGTGTTGAACACAATTG 1201 ATACTTCAGGTGCTTTTGATGTGAAAATCATGAAAAGAGGAACAGGTGGATGTATAGCATTTTTATTCATGCCATCTGTT 1281 TTCAACCAACTATTTTTGAGGAATTATCATGGGAAAAGACCAGGGCTTTTCCCAGGAATATCCCAAACTTCGGAAACAAG 1361 TTATTCTCTTCACTCCCAATAACTAATGCTAAGAAATGCTGAAAATCAAAGTAAAAAATTAAAGCCCATAAGGCCAGAAA 1441 CTCCTTTTGCTGTCTTTCTCTAAATATGATTACTTTAAAATAAAAAAGTAACAAGGTGTCTTTTCCACTCCTATGGAAAA 1521 GGGTCTTCTTGGCAGCTTAACATTGACTTCTTGGTTTGGGGAGAAATAAATTTTGTTTCAGAATTTTGTATATTGTAGGA 1601 ATCCTTTGAGAATGTGATTCCTTTTGATGGGGAGAAAGGGCAAATTATTTTAATATTTTGTATTTTCAACTTTATAAAGA 1681 TAAAATATCCTCAGGGGTGGAGAAGTGTCGTTTTCATAACTTGCTGAATTTCAGGCATTTTGTTCTACATGAGGACTCAT 1761 ATATTTAAGCCTTTTGTGTAATAAGAAAGTATAAAGTCACTTCCAGTGTTGGCTGTGTGACAGAATCTTGTATTTGGGCC 1841 AAGGTGTTTCCATTTCTCAATCAGTGCAGTGATACATGTACTCCAGAGGGACAGGGTGGACCCCCTGAGTCAACTGGAGC 1921 AAGAAGGAAGGAGGCAGACTGATGGCGATTCCCTCTCACCCGGGACTCTCCCCCTTTCAAGGAAAGTGAACCTTTAAAGT 2001 AAAGGCCTCATCTCCTTTATTGCAGTTCAAATCCTCACCATCCACAGCAAGATGAATTTTATCAGCCATGTTTGGTTGTA 2081 AATGCTCGTGTGATTTCCTACAGAAATACTGCTCTGAATATTTTGTAATAAAGGTCTTTGCACATGTGACCACATACGTG 2161 TTAGGAGGCTGCATGCTCTGGAAGCCTGGACTCTAAGCTGGAGCTCTTGGAAGAGCTCTTCGGTTTCTGAGCATAATGCT 2241 CCCATCTCCTGATTTCTCTGAACAGAAAACAAAAGAGAGAATGAGGGAAATTGCTATTTTATTTGTATTCATGAACTTGG 2321 CTGTAATCAGTTATGCCGTATAGGATGTCAGACAATACCACTGGTTAAAATAAAGCCTATTTTTCAAATTTAGTGAGTTT 2401 CTCAAGTTTATTATATTTTTCTCTTGTTTTTATTTAATGCACAATATGGCATTATATCAATATCCTTTAAACTGTGACCT 2481 GGCATACTTGTCTGACAGATCTTAATACTACTCCTAACATTTAGAAAATGTTGATAAAGCTTCTTAGTTGTACATTTTTT 2561 GGTGAAGAGTATCCAGGTCTTTGCTGTGGATGGGTAAAGCAAAGAGCAAATGAACGAAGTATTAAGCATTGGGGCCTGTC 2641 TTATCTACACTCGAGTGTAAGAGTGGCCGAAATGACAGGGCTCAGCAGACTGTGGCCTGAGGGCCAAATCTGGCCCACCA 2721 CCTGTTTGGTGTAGCCTGCTAAGAATGGCTTTTACATTTTTAAATGGTTGGGAAAGAAAAAAAAAGAAGTAGTAGATTTT 2801 GTAGCATGTGATGTAAGTAATGTAAAACTTAAATTCCAGTATCCATAAATAAAGTTTTATGAGAACAGA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | hESCs (WA-09) | ||||||
Disease | 1432.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine
... - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al. - Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
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CLIP-seq Support 1 for dataset SRR359787 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | hESCs (WA-09) / 4-thiouridine, RNase T1 |
Location of target site | ENST00000229795.3 | 3UTR | UGUGCUACAGUGACAGAGGCA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22012620 / SRX103431 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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96 hsa-miR-215-3p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT058509 | TEAD1 | TEA domain transcription factor 1 | 2 | 2 | ||||||||
MIRT445625 | TMEM50A | transmembrane protein 50A | 2 | 2 | ||||||||
MIRT449286 | RPP14 | ribonuclease P/MRP subunit p14 | 2 | 2 | ||||||||
MIRT456702 | LDB1 | LIM domain binding 1 | 2 | 2 | ||||||||
MIRT467723 | SLC38A1 | solute carrier family 38 member 1 | 2 | 2 | ||||||||
MIRT474253 | LATS2 | large tumor suppressor kinase 2 | 2 | 2 | ||||||||
MIRT481811 | AP4E1 | adaptor related protein complex 4 epsilon 1 subunit | 2 | 2 | ||||||||
MIRT491969 | USP37 | ubiquitin specific peptidase 37 | 2 | 2 | ||||||||
MIRT513203 | RFT1 | RFT1 homolog | 2 | 2 | ||||||||
MIRT532737 | CMTM6 | CKLF like MARVEL transmembrane domain containing 6 | 2 | 2 | ||||||||
MIRT535706 | NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | 2 | 2 | ||||||||
MIRT536138 | MAPK14 | mitogen-activated protein kinase 14 | 2 | 2 | ||||||||
MIRT536463 | KLF12 | Kruppel like factor 12 | 2 | 4 | ||||||||
MIRT552615 | ZBTB8A | zinc finger and BTB domain containing 8A | 2 | 2 | ||||||||
MIRT554011 | SPIRE1 | spire type actin nucleation factor 1 | 2 | 2 | ||||||||
MIRT563259 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) | 2 | 2 | ||||||||
MIRT571054 | POLQ | DNA polymerase theta | 2 | 4 | ||||||||
MIRT573556 | TMEM120B | transmembrane protein 120B | 2 | 2 | ||||||||
MIRT573772 | PRKAG1 | protein kinase AMP-activated non-catalytic subunit gamma 1 | 2 | 2 | ||||||||
MIRT575328 | Fbxo6 | F-box protein 6 | 2 | 2 | ||||||||
MIRT575497 | Sept3 | septin 3 | 2 | 5 | ||||||||
MIRT607051 | IDS | iduronate 2-sulfatase | 2 | 2 | ||||||||
MIRT607070 | POM121L7 | POM121 transmembrane nucleoporin like 7 pseudogene | 2 | 2 | ||||||||
MIRT607497 | HEBP2 | heme binding protein 2 | 2 | 2 | ||||||||
MIRT607799 | RHBDL2 | rhomboid like 2 | 2 | 2 | ||||||||
MIRT610832 | COL9A1 | collagen type IX alpha 1 chain | 2 | 2 | ||||||||
MIRT616853 | DSG2 | desmoglein 2 | 2 | 2 | ||||||||
MIRT617154 | C18orf42 | A-kinase anchor inhibitor 1 | 2 | 2 | ||||||||
MIRT620823 | MKI67IP | nucleolar protein interacting with the FHA domain of MKI67 | 1 | 1 | ||||||||
MIRT625698 | OPTN | optineurin | 2 | 2 | ||||||||
MIRT628082 | KAT7 | lysine acetyltransferase 7 | 2 | 2 | ||||||||
MIRT633540 | PGBD5 | piggyBac transposable element derived 5 | 2 | 2 | ||||||||
MIRT634343 | SGOL1 | shugoshin 1 | 2 | 2 | ||||||||
MIRT634605 | KIAA1919 | major facilitator superfamily domain containing 4B | 2 | 2 | ||||||||
MIRT636759 | SLC16A5 | solute carrier family 16 member 5 | 2 | 2 | ||||||||
MIRT637044 | SEPT3 | septin 3 | 2 | 7 | ||||||||
MIRT637213 | TRUB2 | TruB pseudouridine synthase family member 2 | 2 | 2 | ||||||||
MIRT639634 | ZSCAN23 | zinc finger and SCAN domain containing 23 | 2 | 2 | ||||||||
MIRT640818 | GPR107 | G protein-coupled receptor 107 | 2 | 2 | ||||||||
MIRT641033 | PITPNB | phosphatidylinositol transfer protein beta | 2 | 2 | ||||||||
MIRT641545 | MOCOS | molybdenum cofactor sulfurase | 2 | 2 | ||||||||
MIRT642091 | FBXL2 | F-box and leucine rich repeat protein 2 | 2 | 2 | ||||||||
MIRT645528 | ZWINT | ZW10 interacting kinetochore protein | 2 | 2 | ||||||||
MIRT647017 | ADCY2 | adenylate cyclase 2 | 2 | 2 | ||||||||
MIRT648044 | FADS6 | fatty acid desaturase 6 | 2 | 2 | ||||||||
MIRT648514 | PIGG | phosphatidylinositol glycan anchor biosynthesis class G | 2 | 2 | ||||||||
MIRT648869 | ABCA6 | ATP binding cassette subfamily A member 6 | 2 | 2 | ||||||||
MIRT656722 | LMLN | leishmanolysin like peptidase | 2 | 2 | ||||||||
MIRT658260 | FAXC | failed axon connections homolog | 2 | 2 | ||||||||
MIRT659063 | DEPTOR | DEP domain containing MTOR interacting protein | 2 | 2 | ||||||||
MIRT659364 | CRISPLD2 | cysteine rich secretory protein LCCL domain containing 2 | 2 | 2 | ||||||||
MIRT660318 | BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 2 | 2 | ||||||||
MIRT663345 | ZNF74 | zinc finger protein 74 | 2 | 2 | ||||||||
MIRT663526 | MASTL | microtubule associated serine/threonine kinase like | 2 | 2 | ||||||||
MIRT663975 | ZNF786 | zinc finger protein 786 | 2 | 2 | ||||||||
MIRT664354 | C16orf45 | chromosome 16 open reading frame 45 | 2 | 2 | ||||||||
MIRT664473 | ZYG11B | zyg-11 family member B, cell cycle regulator | 2 | 2 | ||||||||
MIRT664975 | TDRD1 | tudor domain containing 1 | 2 | 2 | ||||||||
MIRT665488 | VPS53 | VPS53, GARP complex subunit | 2 | 2 | ||||||||
MIRT667758 | KDELR1 | KDEL endoplasmic reticulum protein retention receptor 1 | 2 | 2 | ||||||||
MIRT669552 | ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | 2 | 2 | ||||||||
MIRT670183 | CCDC142 | coiled-coil domain containing 142 | 2 | 2 | ||||||||
MIRT671342 | FAM71F2 | family with sequence similarity 71 member F2 | 2 | 2 | ||||||||
MIRT671873 | ZNF429 | zinc finger protein 429 | 2 | 2 | ||||||||
MIRT672018 | PXMP4 | peroxisomal membrane protein 4 | 2 | 2 | ||||||||
MIRT672068 | KIAA0930 | KIAA0930 | 2 | 2 | ||||||||
MIRT672551 | BRMS1L | breast cancer metastasis-suppressor 1 like | 2 | 2 | ||||||||
MIRT672849 | ICOSLG | inducible T-cell costimulator ligand | 2 | 2 | ||||||||
MIRT672988 | KBTBD6 | kelch repeat and BTB domain containing 6 | 2 | 2 | ||||||||
MIRT673088 | AK1 | adenylate kinase 1 | 2 | 2 | ||||||||
MIRT673578 | KDELC2 | KDEL motif containing 2 | 2 | 2 | ||||||||
MIRT674582 | SLC35B4 | solute carrier family 35 member B4 | 2 | 2 | ||||||||
MIRT674999 | STRN3 | striatin 3 | 2 | 2 | ||||||||
MIRT675596 | ZNF106 | zinc finger protein 106 | 2 | 2 | ||||||||
MIRT675778 | YIPF4 | Yip1 domain family member 4 | 2 | 2 | ||||||||
MIRT676029 | C9orf69 | transmembrane protein 250 | 2 | 2 | ||||||||
MIRT679015 | MTMR10 | myotubularin related protein 10 | 2 | 2 | ||||||||
MIRT679169 | PSMB2 | proteasome subunit beta 2 | 2 | 2 | ||||||||
MIRT687413 | NRIP1 | nuclear receptor interacting protein 1 | 2 | 2 | ||||||||
MIRT688038 | GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 2 | 2 | ||||||||
MIRT691644 | SLC43A3 | solute carrier family 43 member 3 | 2 | 2 | ||||||||
MIRT695630 | SLC26A2 | solute carrier family 26 member 2 | 2 | 2 | ||||||||
MIRT697562 | ZBTB10 | zinc finger and BTB domain containing 10 | 2 | 2 | ||||||||
MIRT699153 | SMC1A | structural maintenance of chromosomes 1A | 2 | 2 | ||||||||
MIRT699683 | SFMBT2 | Scm like with four mbt domains 2 | 2 | 2 | ||||||||
MIRT702177 | LYRM4 | LYR motif containing 4 | 2 | 2 | ||||||||
MIRT706217 | ACOT9 | acyl-CoA thioesterase 9 | 2 | 2 | ||||||||
MIRT711243 | TRAT1 | T-cell receptor associated transmembrane adaptor 1 | 2 | 2 | ||||||||
MIRT712343 | NLN | neurolysin | 2 | 2 | ||||||||
MIRT716574 | HOPX | HOP homeobox | 2 | 2 | ||||||||
MIRT717443 | TENM1 | teneurin transmembrane protein 1 | 2 | 2 | ||||||||
MIRT717759 | KCNRG | potassium channel regulator | 2 | 2 | ||||||||
MIRT717945 | TUBD1 | tubulin delta 1 | 2 | 2 | ||||||||
MIRT718343 | PURA | purine rich element binding protein A | 2 | 2 | ||||||||
MIRT718773 | ABHD15 | abhydrolase domain containing 15 | 2 | 2 | ||||||||
MIRT737073 | FOXM1 | forkhead box M1 | 2 | 0 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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