miRTarBase - #MIRT537577


—
pre-miRNA Information
pre-miRNA hsa-mir-378f   
Genomic Coordinates chr1: 23929070 - 23929147
Description Homo sapiens miR-378f stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378f
Sequence 52| ACUGGACUUGGAGCCAGAAG |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 18 1 + 23929138 29233923 MiREDiBase
A-to-I 19 1 + 23929139 29233923 MiREDiBase
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ESYT2   
Synonyms CHR2SYT, E-Syt2, FAM62B
Description extended synaptotagmin 2
Transcript NM_020728   
Expression
Putative miRNA Targets on ESYT2
3'UTR of ESYT2
(miRNA target sites are highlighted)		 
>ESYT2|NM_020728|3'UTR
   1 CCGCAGCAGGCAGGAGGCGTCCTCTTCAGCGTAGCTCTCCACCTCTACCCGGAACACACCCTCTCACAGACGTACCAATG
  81 TTATTTTTATAATTTCATGGATTTAGTTATACATACCTTAATAGTTTTATAAAATTGTTGACATTTCAGGCAAATTTGGC
 161 CAATATTATCATTGAATTTTCTGTGTTGGATTTCCTCTAGGATTTCGCCAGTTCCTACAACGTGCAGTAGGGCGGCGGTA
 241 GCTCTTGTGTCTGTGGACTCTGCTCAGCTGTGTCCGTAGGAGTCGGATGTGTCTGTGCTTTATTATGGCCTTGTTTATAT
 321 ATCACTGAGGTATACTATGCCATGTAAATAGACTATTTTTTATAATCTTTACATGCTGGTTTAAATTCAGAAGGAAATAG
 401 ATCAAGGAAATATATATATTTTCTTCTAAAACTTATTAAATTCGTGTGACAAATAATCATTTTCATCTTGGCAGCAAAAA
 481 GTTCTCAGTGACCTATTTTGTGGTGTTTCTTTTTGAAAAGAAAAGCTGAAATATTATTAAATGCTAGTATGTTTCTGCCC
 561 ATTATGAAAGATGAAATAAAGTATTCAAAATATTAACATTTTCATAAATATAAGGATGTATTATTGAGAAGTAAGTTGAA
 641 GGGCTTATAAGGAAAAATGTTTTATAACTGAGTAATATATTAAGAGAATTGTCATGGTTCATAAATCACATTATGCTAAT
 721 CTGAAATTTCTTACATAAAAATGAAGTGTCTTATGTTTATTTTAATTGCTGTTGTAACTTACTCATGAAACAGTATACAG
 801 ACACCTTGTACTTTTCCTCAACTGTAAGAGCAGACTTTCAATGTTAGCAATTAAGCTGTTGTCAAACAATCAGTCATGAG
 881 CTTTGTTAATTTTCAATGTTTTCCCAGCCTATAAAAAAAGGAAGGTACACGTTGTCCTTTTAAAGGTTGTGAGGTAGATT
 961 GGAGTGAGTAGACAGGATATTGCATTAAAAATTGAAAGCTCGATCTCATTATTGTCAGGAACCCCCAGTGTGACCTCACA
1041 CATAGGATGTGGGACCTTTGAGCCGATGTGCACTGGCCACCACCAGGGTTGGGGGCGCCACAGCTGCGAGCCCGGCCCCT
1121 GCTGTTCTCAGCAGCCACTTCCCAGGCTGCCTCACTTTATGCCATGACTGACCTTAATATTGGGATATTGTTATGCAATT
1201 TTTATCCTGTTTAGACTGTTAAAAGCAGGTTTCTGTACTTAAGAGTCCCCCAGACCTCCTGTGAGGTGAGGCTCTGTTGC
1281 AGTGTCGTAGGCTGTGTGTGTCTGTAAAGAAAGAATGCACATATGTAGACGATTAAGTGTATATTATAAGCTATATGCTG
1361 AAAATGGCTTCCATAGCCATGAGAACATCTTAAAACTATGTGTAAATATATTAAGGAAAGTATAGCTTTGTAATTTAAAT
1441 TGGAGCTTTTAGCTTGTTTCATGGAACTATACAACTTGTGGGTAACTCACATGACCAAACAAACCAAAGTGCCTGTGACG
1521 GGGCGGGTGGCGTCTACCCACCCTCCCTTCTAGCAGATTCTTATTTTGTTTGAATTTATAAACAAGGCTGGTGGCTGTCT
1601 ACCCACCCTCCCTTCTAGCAGATTTTGATTTTGTTTCAATTTATAACTTACACTTTGAACCATGGGTTTACTTATAATGG
1681 AGTCTGTAGCTTCACAGCATATTTCATGTAATCATAAAGACCAGTATATTCCCTCCTGCTGAATGACATGCGACTGTAAA
1761 GCCTCTTTATAAACCATTTCCAATGTTAGTATATAGGATTATTTGGGAAGCGTATCAATACCTTTATAGACAAATACGAA
1841 CATGTATGCACACAAAACATTTAACTATGGTATTTATGGAAGACAGGTAACAACATTAAATCTAGTTGCTTTCCCTTAGT
1921 ATTAGATTTGTTGAGGGTTTTTTAAAAATCAGGTCTGTTGAAAGTCTTCTGTCATAATCTATAAAGCAGCAGCACTCATG
2001 GAAATTGTAGCATGCCAGTAATTTTTACCAACATCCCATACATCTGAGTTCTGCAGTCCAGTGTGTAATCCGCTCCATGT
2081 GTATTTTGCTTAATGGAATGCTTTATTTAAGCACTTAGGCAGAGTAGACACAATTAAAGGTACAAAGCCCAGAGGAAGTG
2161 GTAGAGCAGCACCGTGCCTGCCCTGAGGCAGTGGAGTCAGTAGCGCTGTCCCCAGGGCCTTGAGTGCCTGGAGGTGCTTG
2241 GCCTCCAGTAGCTGCCTCCATTCTCTTTTAAAAAAAGGGGGTGATTCTGAGGCACTGAAGTGCCTCCCAGATGTGGAGGA
2321 GTGAAGCCACCATCGAGGCCACACTCAGCACTCCAGGATCCCAGCGATGTCAGACACTCTTGAGTTGTCAAAACGTTAAT
2401 TTTCAGTTTTAAATAATCAGTTTATCTAAGAAAAGGGAATTTTAACTTTTCTACCTTGAGCCAAGCCAATGAAGGGAAAA
2481 TTAATTAACTTAGTAAATTTGAAGTGCAGCTCTGTTAGCTCGTACATGTGGGTTCTTATCCTGATCCTGTGCCTTAAAGT
2561 AGGAAGGTGTTTCCAAGTTCAGATTAAAATAGAAGCAGCTGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTT
2641 GGGAGGCCGAGGCGGGCGGATGACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCCCATCTTTACT
2721 AAAAATACAAAAATTAGCCGGGCGTGGTGGTGGAGCGCACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAA
2801 TTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACT
2881 CCGTCTCAAAAAATAAATAAAATAGAAGCAGCCTTGTAACTGTATTTACCATGATAATATATTCTGCACGGTAAGAATTC
2961 CTTTTACAGACATTCTTTATCAAGAGGTCGGCCCTTCTTTTTCAGGCACATAAGCCAAATGCAGGCCTGTGTGTAGCTGT
3041 GTGTTTTTTCTGTGGTTGCCGCATTTATTCCACCTCCAGCTGGACCCCCCACTGCAAATAGAGAACAGCGGTGGGGGATG
3121 GGGGTTAAAAAGTAGAGAACCTCCTTTCTGTTCAACTAATTTCACGTGACAGTGCATGTATTTATTCAATAAAACCTTTA
3201 TGTTAGCTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaAGAC-CGAGGU-UCAGGUCa 5'
            |||| |:||:: ||||||| 
Target 5' caTCTGAGTTCTGCAGTCCAGt 3'
 2041 - 2062 162.00 -19.40
2 
miRNA  3' gaagACCGAGGUUCAGGUCa 5'
              || :|||||||:||| 
Target 5' aaggTGTTTCCAAGTTCAGa 3'
 2564 - 2583 152.00 -18.40
3 
miRNA  3' gaAGACC-GAGGUUCAGGUCa 5'
            || ||  |:|||| |||| 
Target 5' ggTCAGGAGTTCAAGACCAGc 3'
 2669 - 2689 130.00 -13.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31497457 5 COSMIC
COSN19626370 18 COSMIC
COSN32062529 26 COSMIC
COSN31590525 30 COSMIC
COSN31562351 31 COSMIC
COSN30156931 50 COSMIC
COSN14276112 51 COSMIC
COSN30090685 54 COSMIC
COSN26555136 57 COSMIC
COSN30468728 61 COSMIC
COSN30500765 74 COSMIC
COSN30113754 94 COSMIC
COSN30172249 96 COSMIC
COSN30527110 116 COSMIC
COSN31483899 131 COSMIC
COSN28786621 208 COSMIC
COSN25199225 227 COSMIC
COSN16131229 327 COSMIC
COSN30108935 544 COSMIC
COSN20520529 626 COSMIC
COSN27639596 1212 COSMIC
COSN31962899 1274 COSMIC
COSN19576377 1463 COSMIC
COSN31589090 1475 COSMIC
COSN30173185 1493 COSMIC
COSN31569742 1560 COSMIC
COSN9980441 1697 COSMIC
COSN6873192 1844 COSMIC
COSN15727248 2016 COSMIC
COSN23836188 2071 COSMIC
COSN17076409 2193 COSMIC
COSN27369287 2267 COSMIC
COSN26278762 2270 COSMIC
COSN19661534 2299 COSMIC
COSN23987223 2302 COSMIC
COSN28654228 2368 COSMIC
COSN26464768 2395 COSMIC
COSN26192352 2404 COSMIC
COSN31569769 2448 COSMIC
COSN31551468 2566 COSMIC
COSN31603600 2611 COSMIC
COSN28795408 2618 COSMIC
COSN8789294 2657 COSMIC
COSN21027051 2997 COSMIC
COSN9980440 3042 COSMIC
COSN20105057 3084 COSMIC
rs34119683 1007 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs369199273 2 dbSNP
rs563398485 3 dbSNP
rs761031687 5 dbSNP
rs753425190 8 dbSNP
rs773505911 9 dbSNP
rs751033290 11 dbSNP
rs984437094 12 dbSNP
rs3750051 18 dbSNP
rs762626087 19 dbSNP
rs774975581 22 dbSNP
rs763790875 24 dbSNP
rs760468027 27 dbSNP
rs769395087 28 dbSNP
rs745360476 30 dbSNP
rs374799778 31 dbSNP
rs531797670 34 dbSNP
rs1468781785 36 dbSNP
rs777579613 37 dbSNP
rs1437151453 39 dbSNP
rs372446531 40 dbSNP
rs748447955 50 dbSNP
rs370135037 51 dbSNP
rs1324418934 54 dbSNP
rs562760023 57 dbSNP
rs1020241535 58 dbSNP
rs1007045216 61 dbSNP
rs1221683822 66 dbSNP
rs767454680 67 dbSNP
rs1270061007 70 dbSNP
rs889759191 71 dbSNP
rs549040093 72 dbSNP
rs1259956312 73 dbSNP
rs1393937782 76 dbSNP
rs1200621109 78 dbSNP
rs111251119 82 dbSNP
rs754252941 82 dbSNP
rs954283149 83 dbSNP
rs1331474795 85 dbSNP
rs529351572 100 dbSNP
rs1162045851 101 dbSNP
rs530958273 106 dbSNP
rs1453881479 117 dbSNP
rs1021693202 120 dbSNP
rs1011586088 128 dbSNP
rs560076914 130 dbSNP
rs1303531537 133 dbSNP
rs1344683321 135 dbSNP
rs1403003345 149 dbSNP
rs1290162024 153 dbSNP
rs1336388199 171 dbSNP
rs1403145541 191 dbSNP
rs13438228 197 dbSNP
rs1259128360 198 dbSNP
rs1475325816 199 dbSNP
rs762032849 206 dbSNP
rs529706533 207 dbSNP
rs1251907243 214 dbSNP
rs764613780 214 dbSNP
rs1180484149 220 dbSNP
rs760382920 221 dbSNP
rs186676631 222 dbSNP
rs1163883549 225 dbSNP
rs1048761415 227 dbSNP
rs796789586 230 dbSNP
rs1422318531 233 dbSNP
rs928982395 234 dbSNP
rs990578535 236 dbSNP
rs1061733 237 dbSNP
rs908845204 248 dbSNP
rs1342380353 250 dbSNP
rs148260437 258 dbSNP
rs1314654673 265 dbSNP
rs1357691639 268 dbSNP
rs944316590 269 dbSNP
rs1252343620 270 dbSNP
rs1480583700 273 dbSNP
rs912784932 275 dbSNP
rs369334260 276 dbSNP
rs144878899 284 dbSNP
rs973419374 285 dbSNP
rs990266240 293 dbSNP
rs956103587 298 dbSNP
rs965567136 298 dbSNP
rs1339528129 302 dbSNP
rs1020208837 310 dbSNP
rs1002864961 317 dbSNP
rs1453512197 322 dbSNP
rs1336246963 325 dbSNP
rs1380870267 327 dbSNP
rs1230963325 329 dbSNP
rs1006937177 330 dbSNP
rs374922876 331 dbSNP
rs12643 338 dbSNP
rs1307336788 339 dbSNP
rs1225814060 342 dbSNP
rs1258323358 343 dbSNP
rs1309498145 349 dbSNP
rs1448404249 353 dbSNP
rs141053034 358 dbSNP
rs1330022659 364 dbSNP
rs1187937589 365 dbSNP
rs1262137499 371 dbSNP
rs1032313490 372 dbSNP
rs1000852997 373 dbSNP
rs1392034057 376 dbSNP
rs1431356934 379 dbSNP
rs1470311335 387 dbSNP
rs1175781449 388 dbSNP
rs1022859702 394 dbSNP
rs12670487 403 dbSNP
rs572964411 406 dbSNP
rs949364752 416 dbSNP
rs1384894512 420 dbSNP
rs1303982804 428 dbSNP
rs896288101 436 dbSNP
rs1223516289 441 dbSNP
rs763271902 441 dbSNP
rs1061735 443 dbSNP
rs1236444651 444 dbSNP
rs543218142 444 dbSNP
rs113291704 453 dbSNP
rs1452138931 459 dbSNP
rs1269312523 460 dbSNP
rs1198668407 471 dbSNP
rs1427233850 478 dbSNP
rs1472016003 481 dbSNP
rs1160021896 483 dbSNP
rs984535352 493 dbSNP
rs1451977984 500 dbSNP
rs1305337214 502 dbSNP
rs570462413 505 dbSNP
rs746213722 506 dbSNP
rs1281952738 513 dbSNP
rs1286370975 515 dbSNP
rs77776274 521 dbSNP
rs918956055 537 dbSNP
rs1350965885 540 dbSNP
rs1061739 544 dbSNP
rs1344879421 547 dbSNP
rs183502540 552 dbSNP
rs1436513047 561 dbSNP
rs1332230259 584 dbSNP
rs1326075729 603 dbSNP
rs1293631868 610 dbSNP
rs1385523413 614 dbSNP
rs956139440 615 dbSNP
rs1019756201 631 dbSNP
rs986043042 634 dbSNP
rs61361002 635 dbSNP
rs1177842881 641 dbSNP
rs1407440176 643 dbSNP
rs1032408371 644 dbSNP
rs1417525218 647 dbSNP
rs1421753740 649 dbSNP
rs1000988342 657 dbSNP
rs1366526714 658 dbSNP
rs981869625 664 dbSNP
rs1301761384 665 dbSNP
rs1184273790 668 dbSNP
rs529477594 669 dbSNP
rs1478383123 671 dbSNP
rs1379338829 680 dbSNP
rs1023312506 681 dbSNP
rs1196661487 683 dbSNP
rs1012821306 686 dbSNP
rs951962201 687 dbSNP
rs902509965 697 dbSNP
rs1061747 708 dbSNP
rs712192 713 dbSNP
rs1218469413 715 dbSNP
rs1439491612 719 dbSNP
rs547115321 734 dbSNP
rs1013466095 748 dbSNP
rs1479709446 748 dbSNP
rs1386094863 751 dbSNP
rs879470004 762 dbSNP
rs1487118052 765 dbSNP
rs1422176478 774 dbSNP
rs896415016 775 dbSNP
rs1410986077 790 dbSNP
rs1266441672 792 dbSNP
rs778401456 796 dbSNP
rs1219350572 799 dbSNP
rs1353375830 800 dbSNP
rs1001979852 804 dbSNP
rs1040083411 811 dbSNP
rs1338230805 824 dbSNP
rs1346506619 832 dbSNP
rs533136974 841 dbSNP
rs888820665 848 dbSNP
rs1341277663 849 dbSNP
rs1215041281 861 dbSNP
rs564510510 869 dbSNP
rs1316069789 872 dbSNP
rs929064175 896 dbSNP
rs1363112997 902 dbSNP
rs1345354570 904 dbSNP
rs1299221290 920 dbSNP
rs918883815 920 dbSNP
rs1040461447 930 dbSNP
rs1182018979 931 dbSNP
rs1358915834 945 dbSNP
rs944274543 946 dbSNP
rs912791728 949 dbSNP
rs932910359 952 dbSNP
rs1418011832 957 dbSNP
rs1317864529 965 dbSNP
rs1415177180 968 dbSNP
rs1406227081 978 dbSNP
rs867576090 1001 dbSNP
rs914811315 1002 dbSNP
rs1054644217 1005 dbSNP
rs34119683 1007 dbSNP
rs1431201335 1012 dbSNP
rs924694003 1019 dbSNP
rs1338313875 1021 dbSNP
rs1225345088 1023 dbSNP
rs954189635 1028 dbSNP
rs772975729 1031 dbSNP
rs1322981660 1034 dbSNP
rs979478758 1041 dbSNP
rs1286618585 1047 dbSNP
rs1170834551 1056 dbSNP
rs34372852 1065 dbSNP
rs530844428 1065 dbSNP
rs1261565926 1066 dbSNP
rs1424193861 1067 dbSNP
rs1481689082 1069 dbSNP
rs1195641212 1076 dbSNP
rs1429324156 1081 dbSNP
rs966789413 1087 dbSNP
rs1020933839 1088 dbSNP
rs1476701703 1088 dbSNP
rs866239997 1091 dbSNP
rs1014018064 1094 dbSNP
rs1468865713 1095 dbSNP
rs960768134 1096 dbSNP
rs1033996776 1097 dbSNP
rs138005757 1098 dbSNP
rs951993245 1104 dbSNP
rs1338194728 1106 dbSNP
rs1027504199 1108 dbSNP
rs116134185 1112 dbSNP
rs1202438073 1113 dbSNP
rs1048883145 1114 dbSNP
rs878958855 1119 dbSNP
rs1231178677 1122 dbSNP
rs1279361424 1127 dbSNP
rs779712940 1141 dbSNP
rs993184086 1142 dbSNP
rs1284297283 1151 dbSNP
rs796313313 1154 dbSNP
rs1490950582 1158 dbSNP
rs1227859160 1168 dbSNP
rs1360306761 1180 dbSNP
rs1269890070 1183 dbSNP
rs1019184002 1184 dbSNP
rs1008685380 1186 dbSNP
rs1432029222 1190 dbSNP
rs1196113089 1192 dbSNP
rs888842523 1194 dbSNP
rs755898658 1200 dbSNP
rs1050124969 1213 dbSNP
rs1358337842 1215 dbSNP
rs1010549612 1221 dbSNP
rs1303630762 1226 dbSNP
rs1364874447 1243 dbSNP
rs1385076525 1248 dbSNP
rs1330942684 1251 dbSNP
rs750209789 1254 dbSNP
rs1238543858 1261 dbSNP
rs893413754 1265 dbSNP
rs759650863 1269 dbSNP
rs1054676285 1274 dbSNP
rs767412195 1276 dbSNP
rs1469336768 1281 dbSNP
rs573122199 1286 dbSNP
rs924839016 1287 dbSNP
rs944350572 1298 dbSNP
rs1046318470 1301 dbSNP
rs1172729494 1302 dbSNP
rs950186562 1302 dbSNP
rs1177577892 1312 dbSNP
rs915969009 1321 dbSNP
rs910255872 1325 dbSNP
rs1446142984 1328 dbSNP
rs745831967 1330 dbSNP
rs1367722017 1331 dbSNP
rs1456312271 1333 dbSNP
rs1299841544 1336 dbSNP
rs930605687 1339 dbSNP
rs920519402 1341 dbSNP
rs1390901567 1346 dbSNP
rs796446254 1349 dbSNP
rs971988781 1353 dbSNP
rs962265400 1357 dbSNP
rs1453734412 1366 dbSNP
rs1018801190 1374 dbSNP
rs1320343439 1375 dbSNP
rs1473590494 1380 dbSNP
rs1252438332 1383 dbSNP
rs764292912 1388 dbSNP
rs1197445424 1389 dbSNP
rs1050421405 1394 dbSNP
rs1235333763 1400 dbSNP
rs1462356227 1400 dbSNP
rs953167546 1409 dbSNP
rs1255160916 1419 dbSNP
rs1421871666 1436 dbSNP
rs148842569 1457 dbSNP
rs1373591617 1460 dbSNP
rs1465089657 1467 dbSNP
rs1010582031 1469 dbSNP
rs1168613117 1469 dbSNP
rs893443834 1475 dbSNP
rs1030666603 1476 dbSNP
rs925404303 1477 dbSNP
rs1259341587 1478 dbSNP
rs999156568 1482 dbSNP
rs780349738 1485 dbSNP
rs1326353999 1486 dbSNP
rs1217382096 1490 dbSNP
rs1255581391 1491 dbSNP
rs545892074 1492 dbSNP
rs576716507 1495 dbSNP
rs966758246 1499 dbSNP
rs1045928660 1505 dbSNP
rs1203869523 1509 dbSNP
rs1255059107 1510 dbSNP
rs950234426 1519 dbSNP
rs115737267 1520 dbSNP
rs1262244588 1524 dbSNP
rs758355711 1524 dbSNP
rs992280264 1525 dbSNP
rs980571267 1528 dbSNP
rs538119492 1531 dbSNP
rs558362830 1532 dbSNP
rs1313152857 1539 dbSNP
rs920634305 1551 dbSNP
rs1002036768 1558 dbSNP
rs951981838 1568 dbSNP
rs745968033 1570 dbSNP
rs1439943808 1594 dbSNP
rs1027415812 1600 dbSNP
rs1289788237 1603 dbSNP
rs113067377 1607 dbSNP
rs1165240401 1610 dbSNP
rs1398643192 1612 dbSNP
rs1406852446 1614 dbSNP
rs1285791035 1618 dbSNP
rs1346780411 1619 dbSNP
rs1223609432 1625 dbSNP
rs1300068429 1627 dbSNP
rs1310065538 1637 dbSNP
rs897679199 1639 dbSNP
rs987342098 1643 dbSNP
rs1019105094 1651 dbSNP
rs1439834080 1665 dbSNP
rs1214305452 1666 dbSNP
rs1008678845 1674 dbSNP
rs1176162034 1675 dbSNP
rs1190670185 1678 dbSNP
rs888744273 1683 dbSNP
rs1421083897 1684 dbSNP
rs1232787977 1695 dbSNP
rs555665923 1699 dbSNP
rs1050092740 1719 dbSNP
rs1290693638 1720 dbSNP
rs554254779 1722 dbSNP
rs1418262971 1723 dbSNP
rs1323877488 1731 dbSNP
rs1061620 1732 dbSNP
rs566735346 1733 dbSNP
rs1436476011 1735 dbSNP
rs1245542924 1737 dbSNP
rs111433171 1742 dbSNP
rs867766632 1742 dbSNP
rs1225062039 1747 dbSNP
rs1309570231 1748 dbSNP
rs1311602768 1750 dbSNP
rs546733302 1751 dbSNP
rs1372581319 1752 dbSNP
rs904120091 1759 dbSNP
rs193238351 1768 dbSNP
rs1220806860 1778 dbSNP
rs945519194 1781 dbSNP
rs1271571851 1785 dbSNP
rs1481677982 1790 dbSNP
rs914114864 1791 dbSNP
rs777051393 1797 dbSNP
rs570724952 1807 dbSNP
rs1165862462 1811 dbSNP
rs3763412 1812 dbSNP
rs530956763 1814 dbSNP
rs747530930 1816 dbSNP
rs1163316746 1817 dbSNP
rs1014432136 1818 dbSNP
rs1443743771 1819 dbSNP
rs3763411 1833 dbSNP
rs3763410 1837 dbSNP
rs930751018 1842 dbSNP
rs1316865238 1843 dbSNP
rs1356815515 1845 dbSNP
rs1192271525 1854 dbSNP
rs971992242 1856 dbSNP
rs1287652240 1866 dbSNP
rs113770251 1867 dbSNP
rs569613867 1879 dbSNP
rs1222167736 1886 dbSNP
rs1009026249 1896 dbSNP
rs1488750028 1903 dbSNP
rs1456582666 1909 dbSNP
rs1288395247 1914 dbSNP
rs888891251 1919 dbSNP
rs1028637028 1925 dbSNP
rs1237021036 1942 dbSNP
rs1244072484 1944 dbSNP
rs999852760 1952 dbSNP
rs904213207 1953 dbSNP
rs1220884550 1957 dbSNP
rs1343490224 1958 dbSNP
rs1043998869 1959 dbSNP
rs1411073550 1964 dbSNP
rs931911226 1987 dbSNP
rs545551186 2001 dbSNP
rs779618908 2008 dbSNP
rs1338331042 2016 dbSNP
rs188540295 2017 dbSNP
rs1447037677 2036 dbSNP
rs1056651508 2041 dbSNP
rs1456192514 2042 dbSNP
rs1282274533 2060 dbSNP
rs1363989771 2063 dbSNP
rs3763409 2068 dbSNP
rs543381983 2071 dbSNP
rs957803967 2072 dbSNP
rs1452502471 2077 dbSNP
rs1442148934 2079 dbSNP
rs1359252140 2081 dbSNP
rs574139573 2094 dbSNP
rs1476009820 2105 dbSNP
rs1193601328 2115 dbSNP
rs1422234371 2119 dbSNP
rs3763408 2126 dbSNP
rs3763407 2127 dbSNP
rs1413619454 2133 dbSNP
rs3763406 2135 dbSNP
rs1346802288 2136 dbSNP
rs558512643 2138 dbSNP
rs1199213370 2139 dbSNP
rs1277529248 2140 dbSNP
rs1338439021 2150 dbSNP
rs1225445331 2151 dbSNP
rs1275577187 2154 dbSNP
rs1344574414 2155 dbSNP
rs1198988363 2166 dbSNP
rs1286722922 2169 dbSNP
rs961988910 2173 dbSNP
rs566015427 2180 dbSNP
rs1216438687 2187 dbSNP
rs911692172 2189 dbSNP
rs1478337387 2190 dbSNP
rs987337052 2191 dbSNP
rs1490999678 2195 dbSNP
rs1200362681 2196 dbSNP
rs1377734007 2200 dbSNP
rs953365786 2204 dbSNP
rs1203605053 2205 dbSNP
rs1028730544 2211 dbSNP
rs1409842828 2213 dbSNP
rs573074944 2215 dbSNP
rs1485633531 2226 dbSNP
rs1024635105 2227 dbSNP
rs547494517 2228 dbSNP
rs1256668940 2229 dbSNP
rs1406768826 2236 dbSNP
rs532600658 2237 dbSNP
rs968367673 2241 dbSNP
rs1231284129 2242 dbSNP
rs1281493461 2243 dbSNP
rs374055742 2246 dbSNP
rs13232511 2247 dbSNP
rs1321355449 2252 dbSNP
rs757059404 2252 dbSNP
rs1262397782 2253 dbSNP
rs1211007452 2254 dbSNP
rs1267384558 2270 dbSNP
rs866603742 2270 dbSNP
rs1196228551 2276 dbSNP
rs1034507426 2277 dbSNP
rs539680050 2277 dbSNP
rs1439988095 2278 dbSNP
rs35639425 2282 dbSNP
rs1157823443 2293 dbSNP
rs1378297072 2294 dbSNP
rs1219081286 2295 dbSNP
rs35109208 2299 dbSNP
rs13242618 2302 dbSNP
rs1331038814 2304 dbSNP
rs1377919004 2306 dbSNP
rs1036818224 2310 dbSNP
rs1362064498 2315 dbSNP
rs536003456 2315 dbSNP
rs1304097810 2318 dbSNP
rs1265378113 2327 dbSNP
rs890488252 2330 dbSNP
rs1045119523 2334 dbSNP
rs930736358 2335 dbSNP
rs1457911770 2353 dbSNP
rs1051769106 2355 dbSNP
rs1425340373 2360 dbSNP
rs762993583 2365 dbSNP
rs1036384154 2366 dbSNP
rs13229349 2368 dbSNP
rs765447728 2371 dbSNP
rs1401182259 2382 dbSNP
rs1465249520 2382 dbSNP
rs34291123 2394 dbSNP
rs1428176126 2408 dbSNP
rs953191010 2410 dbSNP
rs769533581 2415 dbSNP
rs1396989803 2416 dbSNP
rs867436357 2427 dbSNP
rs1339224290 2428 dbSNP
rs921798836 2433 dbSNP
rs752068056 2435 dbSNP
rs923693665 2453 dbSNP
rs978475249 2457 dbSNP
rs1185542064 2461 dbSNP
rs776663325 2469 dbSNP
rs1262492849 2471 dbSNP
rs1255773463 2477 dbSNP
rs1484062343 2490 dbSNP
rs1199206725 2492 dbSNP
rs1019932199 2493 dbSNP
rs1009890807 2496 dbSNP
rs990484870 2499 dbSNP
rs1424370519 2504 dbSNP
rs959997360 2505 dbSNP
rs1226353957 2512 dbSNP
rs548456967 2518 dbSNP
rs766748512 2521 dbSNP
rs958958802 2522 dbSNP
rs1361102768 2527 dbSNP
rs1466806857 2529 dbSNP
rs1302605475 2531 dbSNP
rs1314402186 2532 dbSNP
rs1400580975 2541 dbSNP
rs1384371939 2543 dbSNP
rs111664789 2547 dbSNP
rs994965834 2548 dbSNP
rs905335352 2556 dbSNP
rs1275828103 2559 dbSNP
rs1313555666 2565 dbSNP
rs1381390072 2567 dbSNP
rs1233579164 2569 dbSNP
rs1331364939 2572 dbSNP
rs1448175736 2585 dbSNP
rs1482168963 2599 dbSNP
rs1218621796 2600 dbSNP
rs1263838350 2602 dbSNP
rs1045212473 2604 dbSNP
rs994857285 2605 dbSNP
rs1461777929 2609 dbSNP
rs899270291 2610 dbSNP
rs750406407 2611 dbSNP
rs1433963150 2618 dbSNP
rs1175653582 2620 dbSNP
rs1376243840 2621 dbSNP
rs1165690265 2623 dbSNP
rs940683817 2625 dbSNP
rs963482794 2626 dbSNP
rs1360441865 2634 dbSNP
rs1398737897 2635 dbSNP
rs1442945664 2637 dbSNP
rs1386946719 2639 dbSNP
rs911921027 2648 dbSNP
rs1242612880 2649 dbSNP
rs1179289443 2653 dbSNP
rs565410217 2654 dbSNP
rs185515281 2657 dbSNP
rs6972163 2658 dbSNP
rs1195055441 2662 dbSNP
rs1488684724 2667 dbSNP
rs1265518855 2675 dbSNP
rs978603034 2678 dbSNP
rs543104201 2687 dbSNP
rs1243338714 2693 dbSNP
rs57033874 2694 dbSNP
rs1159594818 2698 dbSNP
rs1380127213 2700 dbSNP
rs1309393830 2703 dbSNP
rs375829883 2709 dbSNP
rs1338098630 2711 dbSNP
rs989004155 2712 dbSNP
rs1167563517 2713 dbSNP
rs1391236843 2715 dbSNP
rs959726156 2716 dbSNP
rs1035771050 2720 dbSNP
rs1292499119 2721 dbSNP
rs982289890 2722 dbSNP
rs900439068 2727 dbSNP
rs969630482 2728 dbSNP
rs1391918117 2729 dbSNP
rs1305267231 2737 dbSNP
rs1423007214 2738 dbSNP
rs1023730865 2739 dbSNP
rs546001410 2740 dbSNP
rs182420502 2743 dbSNP
rs1362062515 2744 dbSNP
rs1180988262 2745 dbSNP
rs1452055967 2746 dbSNP
rs530775673 2754 dbSNP
rs1263797499 2755 dbSNP
rs772337300 2755 dbSNP
rs75845000 2756 dbSNP
rs1179517581 2757 dbSNP
rs375178560 2757 dbSNP
rs370268753 2760 dbSNP
rs386720373 2760 dbSNP
rs560575016 2760 dbSNP
rs1184043506 2761 dbSNP
rs372110611 2761 dbSNP
rs542086062 2761 dbSNP
rs1405368157 2763 dbSNP
rs746137603 2763 dbSNP
rs1052204029 2768 dbSNP
rs917643666 2771 dbSNP
rs1206418584 2773 dbSNP
rs1331658701 2774 dbSNP
rs189809283 2780 dbSNP
rs185006273 2781 dbSNP
rs1285803571 2785 dbSNP
rs1379767416 2796 dbSNP
rs1238962902 2801 dbSNP
rs1346649196 2802 dbSNP
rs780953573 2810 dbSNP
rs1285605802 2812 dbSNP
rs937637790 2814 dbSNP
rs1257676042 2816 dbSNP
rs771176753 2819 dbSNP
rs947199694 2820 dbSNP
rs1299032090 2824 dbSNP
rs913088869 2842 dbSNP
rs1139135 2843 dbSNP
rs1382904181 2844 dbSNP
rs1478519326 2853 dbSNP
rs778447636 2856 dbSNP
rs577406289 2858 dbSNP
rs1431289952 2865 dbSNP
rs928296090 2866 dbSNP
rs979749837 2867 dbSNP
rs969725653 2868 dbSNP
rs1447144519 2871 dbSNP
rs746779786 2871 dbSNP
rs1479970326 2873 dbSNP
rs1310996202 2881 dbSNP
rs1342383111 2882 dbSNP
rs1277722981 2883 dbSNP
rs973665525 2890 dbSNP
rs1194896663 2913 dbSNP
rs1444853832 2916 dbSNP
rs777917155 2918 dbSNP
rs1442238741 2922 dbSNP
rs557386842 2930 dbSNP
rs963570560 2934 dbSNP
rs538500115 2935 dbSNP
rs954972267 2940 dbSNP
rs1488937353 2941 dbSNP
rs1193714667 2949 dbSNP
rs1030394123 2950 dbSNP
rs1015517335 2953 dbSNP
rs900537077 2954 dbSNP
rs1324945815 2955 dbSNP
rs758354319 2966 dbSNP
rs1171585373 2967 dbSNP
rs1362370670 2971 dbSNP
rs1400582704 2972 dbSNP
rs1222133819 2974 dbSNP
rs1345262795 2983 dbSNP
rs1032339877 2986 dbSNP
rs1271082388 2987 dbSNP
rs752512084 2989 dbSNP
rs1275668689 2992 dbSNP
rs902413740 3005 dbSNP
rs1324872085 3007 dbSNP
rs1062119 3009 dbSNP
rs2013 3010 dbSNP
rs386720372 3011 dbSNP
rs879345551 3011 dbSNP
rs1408262448 3013 dbSNP
rs548617528 3021 dbSNP
rs535051624 3022 dbSNP
rs537601969 3028 dbSNP
rs1246912255 3029 dbSNP
rs1469176232 3035 dbSNP
rs1424077025 3041 dbSNP
rs1188002735 3052 dbSNP
rs1474234497 3059 dbSNP
rs112439287 3060 dbSNP
rs17837836 3061 dbSNP
rs532322482 3071 dbSNP
rs1420186359 3085 dbSNP
rs1245579584 3088 dbSNP
rs938414581 3089 dbSNP
rs149498337 3091 dbSNP
rs928361714 3099 dbSNP
rs1324352774 3100 dbSNP
rs1044149015 3102 dbSNP
rs773548930 3104 dbSNP
rs984043593 3109 dbSNP
rs114181147 3110 dbSNP
rs1030840531 3113 dbSNP
rs919628244 3119 dbSNP
rs1259496657 3122 dbSNP
rs868226373 3124 dbSNP
rs964770298 3132 dbSNP
rs974862947 3132 dbSNP
rs1467738462 3133 dbSNP
rs1032372508 3136 dbSNP
rs1216643365 3136 dbSNP
rs17837835 3141 dbSNP
rs1361984031 3150 dbSNP
rs566052589 3153 dbSNP
rs529757183 3157 dbSNP
rs1269795538 3165 dbSNP
rs908014371 3166 dbSNP
rs896355169 3174 dbSNP
rs1333620594 3175 dbSNP
rs560685579 3189 dbSNP
rs774662806 3195 dbSNP
rs1385103296 3202 dbSNP
rs1054882807 3205 dbSNP
rs1342747078 3209 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 57488.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaAGAC-CGAGGU-UCAGGUCa 5'
            |||| |:||:: ||||||| 
Target 5' --UCUGAGUUCUGCAGUCCAGu 3'
 		1 - 20
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000251527.5 | 3UTR | UCUGAGUUCUGCAGUCCAGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
27 hsa-miR-378f Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT463100 ZNF609 zinc finger protein 609 2 2
MIRT469371 REST RE1 silencing transcription factor 2 6
MIRT495441 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513606 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520414 TXNL1 thioredoxin like 1 2 4
MIRT525111 PRKD2 protein kinase D2 2 2
MIRT525979 SPA17 sperm autoantigenic protein 17 2 2
MIRT527002 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529215 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529835 ARGFX arginine-fifty homeobox 2 2
MIRT532300 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537577 ESYT2 extended synaptotagmin 2 2 2
MIRT543140 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554924 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564970 WTAP WT1 associated protein 2 2
MIRT570115 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652734 TGFB2 transforming growth factor beta 2 2 2
MIRT655948 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT655997 MYRF myelin regulatory factor 2 2
MIRT684875 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692969 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693737 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710991 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712247 RCC2 regulator of chromosome condensation 2 2 2
MIRT718602 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723499 WDR33 WD repeat domain 33 2 2
MIRT725448 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-378f Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-378f Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-mir-378f Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)

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