pre-miRNA Information
pre-miRNA hsa-mir-660   
Genomic Coordinates chrX: 50013241 - 50013337
Synonyms MIRN660, hsa-mir-660, MIR660
Description Homo sapiens miR-660 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-660-3p
Sequence 52| ACCUCCUGUGUGCAUGGAUUA |72
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1221699333 1 dbSNP
rs781893004 6 dbSNP
rs180785970 8 dbSNP
rs1272406504 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DBN1   
Synonyms D0S117E
Description drebrin 1
Transcript NM_004395   
Other Transcripts NM_080881   
Expression
Putative miRNA Targets on DBN1
3'UTR of DBN1
(miRNA target sites are highlighted)
>DBN1|NM_004395|3'UTR
   1 CGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGC
  81 ATTCGCAGCAGCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCC
 161 TGACTTTTACAGCTTTTCTCTTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGT
 241 TGAGACGCTGTTGCAAATTCCACCCCTCCTTCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGT
 321 TGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTA
 401 TGTTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATATTTTGCACGAATTTTAAAACATGGCAATAA
 481 ATGGCTCGTGGGCTCTGGCTCCCTGGGACCCCCTCCCCGCCCTTCTTTTGACCCCTTCCTGTCTGGCCCAAAGGAAGTAG
 561 CAGGCCCAGCTGGGGCCCCTCGGCTACCCCCCGTCTCCTGCCGGGCAGGTCCCAGGTTGGAGGCCCTAGGCGCGGTTCAG
 641 GTCAGGGCTATGGATGGGGCCCAGGGGCTTTGGTGGCCCCTCCCCAACTCCTTCCTCTTTGCTTGGGTTCCTTTTTCACG
 721 TTTAGTAACTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGAAAGCACAAACTTCTGTAACGGGTCGTGCTCATGTCTGT
 801 TAATAAAGAAATCCAGATCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' auUAGGUA-CGUGUGUCCUCca 5'
            ||  || | :| ||||:|  
Target 5' ctATGGATGGGGCCCAGGGGct 3'
648 - 669 115.00 -9.50
2
miRNA  3' auuaggUACGUGUGUCCUCca 5'
                | |:  |:|||||  
Target 5' tttaaaAAGTTGATAGGAGac 3'
185 - 205 111.00 -8.00
3
miRNA  3' auuAGGUACGUGUGUCCUcca 5'
             ||| | | ||||||:   
Target 5' gctTCCCTACCCACAGGGcct 3'
141 - 161 110.00 -10.32
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31494342 26 COSMIC
COSN30165795 36 COSMIC
COSN30135917 37 COSMIC
COSN22622887 62 COSMIC
COSN30565882 69 COSMIC
COSN26972798 84 COSMIC
COSN26438095 98 COSMIC
COSN30101447 106 COSMIC
COSN30502009 128 COSMIC
COSN16806197 187 COSMIC
COSN31572403 246 COSMIC
COSN31563235 317 COSMIC
COSN31535620 350 COSMIC
COSN8492410 666 COSMIC
COSN31594555 681 COSMIC
COSN9422090 723 COSMIC
COSN17182900 787 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs368470978 1 dbSNP
rs769546229 1 dbSNP
rs749644699 8 dbSNP
rs773620501 10 dbSNP
rs1326267698 15 dbSNP
rs574371600 16 dbSNP
rs1417524665 20 dbSNP
rs1362097835 22 dbSNP
rs748691709 22 dbSNP
rs555696878 24 dbSNP
rs768634940 25 dbSNP
rs747191358 28 dbSNP
rs780139643 35 dbSNP
rs374930581 36 dbSNP
rs753664791 37 dbSNP
rs981679899 38 dbSNP
rs777753551 45 dbSNP
rs756080822 46 dbSNP
rs745487195 47 dbSNP
rs970004667 64 dbSNP
rs1023272972 65 dbSNP
rs1309940541 67 dbSNP
rs1374138757 68 dbSNP
rs992271359 69 dbSNP
rs960393231 70 dbSNP
rs957337198 72 dbSNP
rs1273596704 75 dbSNP
rs1339654657 80 dbSNP
rs1206779459 83 dbSNP
rs1031662801 85 dbSNP
rs998973391 94 dbSNP
rs538160706 95 dbSNP
rs901923810 96 dbSNP
rs1034374382 102 dbSNP
rs1040547324 106 dbSNP
rs1008106891 107 dbSNP
rs1389866090 109 dbSNP
rs1382656016 111 dbSNP
rs1355234686 112 dbSNP
rs1457441488 118 dbSNP
rs1378357862 119 dbSNP
rs889386628 123 dbSNP
rs1296609924 130 dbSNP
rs570852313 131 dbSNP
rs1300563169 138 dbSNP
rs774123837 140 dbSNP
rs1467187192 147 dbSNP
rs1359357981 150 dbSNP
rs1167615586 158 dbSNP
rs1297850176 159 dbSNP
rs1427455675 160 dbSNP
rs752471209 164 dbSNP
rs1489755638 167 dbSNP
rs1214857714 179 dbSNP
rs1247855824 183 dbSNP
rs552450248 187 dbSNP
rs1420528378 188 dbSNP
rs1423417781 188 dbSNP
rs1162791277 194 dbSNP
rs1036647937 198 dbSNP
rs928335769 201 dbSNP
rs534155049 204 dbSNP
rs1436968990 206 dbSNP
rs1289191116 208 dbSNP
rs892517629 208 dbSNP
rs948532361 210 dbSNP
rs1183654139 224 dbSNP
rs567037507 226 dbSNP
rs1483645216 231 dbSNP
rs1334901304 232 dbSNP
rs1051185804 233 dbSNP
rs1234490310 235 dbSNP
rs915850738 246 dbSNP
rs1327647412 254 dbSNP
rs1203228743 256 dbSNP
rs1344600723 258 dbSNP
rs111834617 273 dbSNP
rs934019819 274 dbSNP
rs1180335649 281 dbSNP
rs1258426053 286 dbSNP
rs548406609 296 dbSNP
rs899819917 302 dbSNP
rs1475564801 312 dbSNP
rs1039388076 313 dbSNP
rs530177977 317 dbSNP
rs1321037086 323 dbSNP
rs1358355072 351 dbSNP
rs556109981 352 dbSNP
rs1408718079 353 dbSNP
rs768309990 355 dbSNP
rs867424899 375 dbSNP
rs977378387 380 dbSNP
rs1327724657 381 dbSNP
rs1225913180 382 dbSNP
rs909057440 383 dbSNP
rs1355494896 388 dbSNP
rs147415882 398 dbSNP
rs1311964389 401 dbSNP
rs1306895261 402 dbSNP
rs984550046 417 dbSNP
rs1019416308 418 dbSNP
rs1007744304 424 dbSNP
rs1181581501 425 dbSNP
rs1249623371 426 dbSNP
rs1473570511 428 dbSNP
rs929139512 429 dbSNP
rs1424259258 432 dbSNP
rs889306053 433 dbSNP
rs189418085 436 dbSNP
rs1375698478 438 dbSNP
rs1428645196 439 dbSNP
rs1305650026 441 dbSNP
rs1351798013 442 dbSNP
rs72815109 444 dbSNP
rs1280627097 448 dbSNP
rs56142909 465 dbSNP
rs1372023943 471 dbSNP
rs995084990 485 dbSNP
rs898080663 487 dbSNP
rs1348874756 490 dbSNP
rs753969166 491 dbSNP
rs939656465 506 dbSNP
rs55705853 509 dbSNP
rs1205182402 510 dbSNP
rs1035754453 514 dbSNP
rs1246083283 514 dbSNP
rs562476833 514 dbSNP
rs1192715232 516 dbSNP
rs1395389294 518 dbSNP
rs1448572265 522 dbSNP
rs926284694 526 dbSNP
rs906966447 532 dbSNP
rs1166322115 536 dbSNP
rs546105261 541 dbSNP
rs1061378 543 dbSNP
rs968258405 549 dbSNP
rs1022476970 557 dbSNP
rs1009780282 563 dbSNP
rs756361955 565 dbSNP
rs1030190917 566 dbSNP
rs1349834706 567 dbSNP
rs1061379 570 dbSNP
rs528864668 576 dbSNP
rs899850827 579 dbSNP
rs1372161858 586 dbSNP
rs560267391 588 dbSNP
rs989977255 589 dbSNP
rs1295637774 590 dbSNP
rs541564661 591 dbSNP
rs574436044 592 dbSNP
rs559855512 593 dbSNP
rs765073404 593 dbSNP
rs1253461280 595 dbSNP
rs1007432335 597 dbSNP
rs1186325765 603 dbSNP
rs1374467841 605 dbSNP
rs1475510651 606 dbSNP
rs1162145417 613 dbSNP
rs887732934 615 dbSNP
rs1410988082 620 dbSNP
rs966011714 628 dbSNP
rs1328491444 631 dbSNP
rs1395726113 633 dbSNP
rs1434861432 634 dbSNP
rs1048958967 635 dbSNP
rs1318890600 638 dbSNP
rs1328437611 648 dbSNP
rs1196138680 650 dbSNP
rs1018928511 651 dbSNP
rs929170544 657 dbSNP
rs555833886 661 dbSNP
rs1246836539 672 dbSNP
rs1335403973 676 dbSNP
rs1263516001 677 dbSNP
rs192155867 677 dbSNP
rs1186383107 679 dbSNP
rs1028278503 680 dbSNP
rs1056634597 682 dbSNP
rs1475884382 685 dbSNP
rs1164957358 686 dbSNP
rs1419232959 691 dbSNP
rs569266064 694 dbSNP
rs994927537 695 dbSNP
rs1351931624 699 dbSNP
rs1387592541 699 dbSNP
rs1401566292 701 dbSNP
rs898092142 701 dbSNP
rs1015102497 705 dbSNP
rs760991269 706 dbSNP
rs1349812745 708 dbSNP
rs1262328450 710 dbSNP
rs1351098840 711 dbSNP
rs1329179478 718 dbSNP
rs1276102030 719 dbSNP
rs1385908006 720 dbSNP
rs1188056707 722 dbSNP
rs1388966699 722 dbSNP
rs1250340048 724 dbSNP
rs1295670389 725 dbSNP
rs1462364315 729 dbSNP
rs1180274100 731 dbSNP
rs1429242237 731 dbSNP
rs1172323301 732 dbSNP
rs1454606087 732 dbSNP
rs1157019508 733 dbSNP
rs1436756669 733 dbSNP
rs1003855323 735 dbSNP
rs1313566445 735 dbSNP
rs1309017980 736 dbSNP
rs1232287212 737 dbSNP
rs1272799144 737 dbSNP
rs1473642668 737 dbSNP
rs1273362410 738 dbSNP
rs1349599712 738 dbSNP
rs558854269 738 dbSNP
rs1412932198 739 dbSNP
rs1194633248 740 dbSNP
rs906889281 740 dbSNP
rs1198614325 741 dbSNP
rs1481830996 741 dbSNP
rs59430269 741 dbSNP
rs73804353 741 dbSNP
rs1299912887 742 dbSNP
rs1389672508 742 dbSNP
rs1045393287 743 dbSNP
rs1386076546 744 dbSNP
rs1264929896 745 dbSNP
rs1372887473 745 dbSNP
rs1234636731 746 dbSNP
rs1211415827 747 dbSNP
rs1296380587 747 dbSNP
rs1229009001 748 dbSNP
rs1339591032 748 dbSNP
rs894184854 749 dbSNP
rs1468852612 750 dbSNP
rs1470079964 751 dbSNP
rs1267488538 752 dbSNP
rs1206256114 753 dbSNP
rs1330560943 754 dbSNP
rs1279655790 755 dbSNP
rs1194610612 757 dbSNP
rs1232009714 759 dbSNP
rs1172624468 760 dbSNP
rs1185851682 760 dbSNP
rs1214721598 760 dbSNP
rs1244748591 760 dbSNP
rs1252183372 760 dbSNP
rs1271860466 760 dbSNP
rs1295754106 760 dbSNP
rs1319593062 760 dbSNP
rs1320579280 760 dbSNP
rs1373710066 760 dbSNP
rs1383491208 760 dbSNP
rs1396466355 760 dbSNP
rs1423288950 760 dbSNP
rs1426901955 760 dbSNP
rs1441412713 760 dbSNP
rs1457394612 760 dbSNP
rs1491053311 760 dbSNP
rs72166670 760 dbSNP
rs748471889 760 dbSNP
rs769644085 760 dbSNP
rs778355813 760 dbSNP
rs869098747 760 dbSNP
rs1329004720 761 dbSNP
rs1461846834 761 dbSNP
rs939087444 772 dbSNP
rs1343211259 775 dbSNP
rs1455077065 777 dbSNP
rs1289066430 778 dbSNP
rs926290336 781 dbSNP
rs1412408822 782 dbSNP
rs1294531843 786 dbSNP
rs1357921930 787 dbSNP
rs1234430024 788 dbSNP
rs1442174241 792 dbSNP
rs534467811 793 dbSNP
rs1218258362 796 dbSNP
rs372688836 801 dbSNP
rs1261566597 808 dbSNP
rs1054296494 812 dbSNP
rs1319181944 815 dbSNP
rs1185920337 820 dbSNP
rs980395204 821 dbSNP
rs867584165 824 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 1627.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' auuAGGUACGU--GUGUCCUCCa 5'
             |:||  ||  ||||||||| 
Target 5' uacUUCAGUCAAUCACAGGAGGa 3'
6 - 28
2
miRNA  3' auuagguacgugugUCCUCca 5'
                        |||:|  
Target 5' --------------AGGGGua 3'
1 - 7
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000512501.1 | 3UTR | agggguacuucagucaaucacaggaggagg
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
348 hsa-miR-660-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059151 TXNIP thioredoxin interacting protein 2 2
MIRT294324 ZNF264 zinc finger protein 264 2 2
MIRT306043 SKIL SKI like proto-oncogene 2 4
MIRT392841 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT444084 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT458774 CES2 carboxylesterase 2 2 2
MIRT460273 SLC26A2 solute carrier family 26 member 2 2 2
MIRT462675 HMOX1 heme oxygenase 1 2 4
MIRT473711 MAPK1 mitogen-activated protein kinase 1 2 6
MIRT478539 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT483234 FAM13C family with sequence similarity 13 member C 2 4
MIRT486255 BCORL1 BCL6 corepressor like 1 2 2
MIRT501951 MAT2A methionine adenosyltransferase 2A 2 10
MIRT513043 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT513249 FBXO17 F-box protein 17 2 2
MIRT526940 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 2
MIRT528176 C6orf47 chromosome 6 open reading frame 47 2 2
MIRT531525 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT532746 CMTM6 CKLF like MARVEL transmembrane domain containing 6 2 2
MIRT534241 SLC23A1 solute carrier family 23 member 1 2 2
MIRT538198 DBN1 drebrin 1 2 2
MIRT539305 AMOTL1 angiomotin like 1 2 2
MIRT539567 CNKSR3 CNKSR family member 3 2 4
MIRT540043 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT540232 SAMD5 sterile alpha motif domain containing 5 2 2
MIRT540251 RGS17 regulator of G protein signaling 17 2 2
MIRT540878 ZBTB24 zinc finger and BTB domain containing 24 2 2
MIRT543484 RXRA retinoid X receptor alpha 2 2
MIRT551435 F2 coagulation factor II, thrombin 2 2
MIRT553925 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT556312 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556943 ING1 inhibitor of growth family member 1 2 2
MIRT569883 EFEMP2 EGF containing fibulin like extracellular matrix protein 2 2 2
MIRT571849 NRBF2 nuclear receptor binding factor 2 2 2
MIRT572420 VWA5A von Willebrand factor A domain containing 5A 2 2
MIRT572495 BTN2A2 butyrophilin subfamily 2 member A2 2 2
MIRT572564 AFF1 AF4/FMR2 family member 1 2 2
MIRT572883 CHST15 carbohydrate sulfotransferase 15 2 2
MIRT574988 Slc38a5 solute carrier family 38, member 5 2 4
MIRT575264 Timp3 tissue inhibitor of metalloproteinase 3 2 2
MIRT608476 RRP36 ribosomal RNA processing 36 2 4
MIRT608529 TMOD3 tropomodulin 3 2 2
MIRT608578 RNF149 ring finger protein 149 2 2
MIRT608615 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT608679 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT608727 ZKSCAN1 zinc finger with KRAB and SCAN domains 1 2 2
MIRT609575 CATSPER4 cation channel sperm associated 4 2 2
MIRT609710 TMEM132C transmembrane protein 132C 2 2
MIRT609858 DAZAP2 DAZ associated protein 2 2 2
MIRT610262 LRRC47 leucine rich repeat containing 47 2 2
MIRT610349 AGTRAP angiotensin II receptor associated protein 2 2
MIRT610729 PEA15 phosphoprotein enriched in astrocytes 15 2 4
MIRT610803 KLK2 kallikrein related peptidase 2 2 2
MIRT610968 MAFK MAF bZIP transcription factor K 2 2
MIRT611117 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2 2
MIRT611600 JAKMIP3 Janus kinase and microtubule interacting protein 3 2 4
MIRT612211 TMEM109 transmembrane protein 109 2 2
MIRT612248 MICALL1 MICAL like 1 2 2
MIRT613252 CAV1 caveolin 1 2 4
MIRT613323 ARID3A AT-rich interaction domain 3A 2 4
MIRT613514 CDKN2AIPNL CDKN2A interacting protein N-terminal like 2 2
MIRT613605 TP53 tumor protein p53 2 2
MIRT613632 ARHGAP35 Rho GTPase activating protein 35 2 2
MIRT613809 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT614835 PRKCA protein kinase C alpha 2 2
MIRT614985 GIPC1 GIPC PDZ domain containing family member 1 2 2
MIRT615320 MLXIPL MLX interacting protein like 2 2
MIRT615504 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT615529 SPANXN5 SPANX family member N5 2 2
MIRT615610 SPANXN1 SPANX family member N1 2 2
MIRT615755 C6 complement C6 2 2
MIRT615952 SORD sorbitol dehydrogenase 2 2
MIRT616284 HMGB1 high mobility group box 1 2 2
MIRT616626 KCNJ11 potassium voltage-gated channel subfamily J member 11 2 4
MIRT616882 DGCR14 ess-2 splicing factor homolog 2 2
MIRT616994 COL19A1 collagen type XIX alpha 1 chain 2 2
MIRT617080 SPIB Spi-B transcription factor 2 2
MIRT617345 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT617712 RUSC2 RUN and SH3 domain containing 2 2 2
MIRT618102 PPP5D1 PPP5 tetratricopeptide repeat domain containing 1 2 2
MIRT618493 DENND5B DENN domain containing 5B 2 4
MIRT618756 SLC38A5 solute carrier family 38 member 5 2 5
MIRT619928 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT620028 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620087 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT620209 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620557 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620770 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT620784 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT620895 ANO7 anoctamin 7 2 2
MIRT621284 PIWIL1 piwi like RNA-mediated gene silencing 1 2 2
MIRT622594 PRRG4 proline rich and Gla domain 4 2 2
MIRT623273 MED28 mediator complex subunit 28 2 2
MIRT624247 VSIG2 V-set and immunoglobulin domain containing 2 2 2
MIRT624298 COMMD2 COMM domain containing 2 2 2
MIRT624526 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT624567 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT624692 AR androgen receptor 2 2
MIRT624767 AKR1D1 aldo-keto reductase family 1 member D1 2 2
MIRT624829 ACO1 aconitase 1 2 2
MIRT625159 ZCCHC8 zinc finger CCHC-type containing 8 2 4
MIRT625261 ZNF566 zinc finger protein 566 2 2
MIRT625388 ZNF716 zinc finger protein 716 2 2
MIRT625827 FBXO42 F-box protein 42 2 2
MIRT625837 NXPE2 neurexophilin and PC-esterase domain family member 2 2 2
MIRT626021 XRCC2 X-ray repair cross complementing 2 2 2
MIRT626052 PDE4C phosphodiesterase 4C 2 2
MIRT626354 PACS1 phosphofurin acidic cluster sorting protein 1 2 2
MIRT626778 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 2
MIRT627050 HOXA13 homeobox A13 2 2
MIRT627274 XIAP X-linked inhibitor of apoptosis 2 2
MIRT627310 WDR31 WD repeat domain 31 2 2
MIRT627916 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT630557 CCDC107 coiled-coil domain containing 107 2 2
MIRT630775 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT632083 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT633138 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT633711 PEX26 peroxisomal biogenesis factor 26 2 4
MIRT634361 RNF157 ring finger protein 157 2 2
MIRT635739 IFNAR1 interferon alpha and beta receptor subunit 1 2 2
MIRT636963 APTX aprataxin 2 2
MIRT637373 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT637815 GGPS1 geranylgeranyl diphosphate synthase 1 2 2
MIRT637911 FAM153B family with sequence similarity 153 member B 2 2
MIRT638474 PANK3 pantothenate kinase 3 2 2
MIRT638633 GSR glutathione-disulfide reductase 2 4
MIRT639493 TSPAN1 tetraspanin 1 2 2
MIRT639773 GPR45 G protein-coupled receptor 45 2 2
MIRT639781 RAX retina and anterior neural fold homeobox 2 2
MIRT639915 SLIT1 slit guidance ligand 1 2 2
MIRT640055 MCL1 MCL1, BCL2 family apoptosis regulator 2 4
MIRT640108 DUOX2 dual oxidase 2 2 2
MIRT640402 ZNF785 zinc finger protein 785 2 2
MIRT640555 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT640751 ZBTB26 zinc finger and BTB domain containing 26 2 2
MIRT640765 GLO1 glyoxalase I 2 2
MIRT640915 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641521 CREBBP CREB binding protein 2 2
MIRT641533 SNW1 SNW domain containing 1 2 2
MIRT641692 SPCS1 signal peptidase complex subunit 1 2 2
MIRT641745 MACROD2 MACRO domain containing 2 2 2
MIRT641866 STOML1 stomatin like 1 2 2
MIRT641951 RNF115 ring finger protein 115 2 2
MIRT642205 SMAGP small cell adhesion glycoprotein 2 2
MIRT642420 CILP2 cartilage intermediate layer protein 2 2 2
MIRT643028 LETM2 leucine zipper and EF-hand containing transmembrane protein 2 2 2
MIRT643406 PAX1 paired box 1 2 2
MIRT643500 ZNF195 zinc finger protein 195 2 2
MIRT643754 LEFTY2 left-right determination factor 2 2 2
MIRT643898 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT644036 CENPM centromere protein M 2 2
MIRT644200 LAT2 linker for activation of T-cells family member 2 2 2
MIRT644228 ADD1 adducin 1 2 2
MIRT644690 GPR55 G protein-coupled receptor 55 2 2
MIRT645128 HES2 hes family bHLH transcription factor 2 2 2
MIRT645347 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT645897 ATP2B3 ATPase plasma membrane Ca2+ transporting 3 2 2
MIRT645905 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT646049 NPR1 natriuretic peptide receptor 1 2 2
MIRT646137 C1orf147 chromosome 1 open reading frame 147 2 2
MIRT646219 DUSP10 dual specificity phosphatase 10 2 2
MIRT646385 SLC22A6 solute carrier family 22 member 6 2 2
MIRT646739 FADS1 fatty acid desaturase 1 2 2
MIRT646877 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT647109 GNL3L G protein nucleolar 3 like 2 2
MIRT647523 PPIE peptidylprolyl isomerase E 2 2
MIRT647553 CYP2B6 cytochrome P450 family 2 subfamily B member 6 2 2
MIRT647755 NBPF3 NBPF member 3 2 2
MIRT648075 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648225 TM4SF20 transmembrane 4 L six family member 20 2 2
MIRT648441 MYOZ3 myozenin 3 2 2
MIRT648823 ZNF689 zinc finger protein 689 2 2
MIRT649229 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT649237 FEM1A fem-1 homolog A 2 2
MIRT649249 TRIM65 tripartite motif containing 65 2 2
MIRT649459 WDR70 WD repeat domain 70 2 2
MIRT649637 RASA4 RAS p21 protein activator 4 2 2
MIRT650745 FKTN fukutin 2 2
MIRT651041 ZNF652 zinc finger protein 652 2 2
MIRT651754 VEGFA vascular endothelial growth factor A 2 2
MIRT651799 UST uronyl 2-sulfotransferase 2 2
MIRT652562 TLX1 T-cell leukemia homeobox 1 2 2
MIRT652776 TENM3 teneurin transmembrane protein 3 2 2
MIRT652939 SYNGR1 synaptogyrin 1 2 2
MIRT653006 STXBP5L syntaxin binding protein 5 like 2 2
MIRT653030 STX1B syntaxin 1B 2 2
MIRT653279 SNAP29 synaptosome associated protein 29 2 2
MIRT654057 S1PR1 sphingosine-1-phosphate receptor 1 2 2
MIRT654329 RBM33 RNA binding motif protein 33 2 2
MIRT654650 PTAFR platelet activating factor receptor 2 2
MIRT656577 LSM10 LSM10, U7 small nuclear RNA associated 2 2
MIRT656595 LSAMP limbic system-associated membrane protein 2 2
MIRT656646 LRIG1 leucine rich repeats and immunoglobulin like domains 1 2 2
MIRT656739 LMBR1L limb development membrane protein 1 like 2 2
MIRT656903 KIAA1958 KIAA1958 2 2
MIRT657392 HM13 histocompatibility minor 13 2 2
MIRT657528 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT657611 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT657668 GPR26 G protein-coupled receptor 26 2 2
MIRT657689 GPR155 G protein-coupled receptor 155 2 2
MIRT657818 GJD3 gap junction protein delta 3 2 2
MIRT658410 FAM208A family with sequence similarity 208 member A 2 2
MIRT658955 DNMT3A DNA methyltransferase 3 alpha 2 2
MIRT659425 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT659499 CISD3 CDGSH iron sulfur domain 3 2 2
MIRT659994 C2CD2L C2CD2 like 2 2
MIRT660215 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT660493 ARRDC3 arrestin domain containing 3 2 2
MIRT660761 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660827 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT661576 EPHX2 epoxide hydrolase 2 2 2
MIRT661711 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661826 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT662123 APOL6 apolipoprotein L6 2 2
MIRT662254 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT662314 ADM2 adrenomedullin 2 2 2
MIRT662341 MYLK3 myosin light chain kinase 3 2 2
MIRT662453 SEMA5A semaphorin 5A 2 2
MIRT662746 LRRC3C leucine rich repeat containing 3C 2 2
MIRT662901 GJB1 gap junction protein beta 1 2 2
MIRT663018 KIAA1586 KIAA1586 2 2
MIRT663102 THEM4 thioesterase superfamily member 4 2 2
MIRT663574 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT664125 C4orf32 family with sequence similarity 241 member A 2 2
MIRT664560 SORBS2 sorbin and SH3 domain containing 2 2 2
MIRT665589 TUBD1 tubulin delta 1 2 2
MIRT666464 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT666527 RNF170 ring finger protein 170 2 2
MIRT666874 POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2 2
MIRT667055 PARVA parvin alpha 2 2
MIRT667282 NAV1 neuron navigator 1 2 2
MIRT667928 IGLON5 IgLON family member 5 2 2
MIRT667957 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 2 2
MIRT668336 FKBP5 FK506 binding protein 5 2 2
MIRT668718 DIP2C disco interacting protein 2 homolog C 2 2
MIRT669310 C17orf75 chromosome 17 open reading frame 75 2 2
MIRT669688 ABLIM1 actin binding LIM protein 1 2 2
MIRT671524 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 2
MIRT672112 TLCD2 TLC domain containing 2 2 4
MIRT672186 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT672702 ZNF677 zinc finger protein 677 2 2
MIRT673473 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT673617 HPSE heparanase 2 2
MIRT673763 ZNF333 zinc finger protein 333 2 2
MIRT674817 FAM229B family with sequence similarity 229 member B 2 2
MIRT675304 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT675404 SVOP SV2 related protein 2 2
MIRT676163 OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 2 2
MIRT676320 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT676347 PCCB propionyl-CoA carboxylase beta subunit 2 2
MIRT676526 RNF216 ring finger protein 216 2 2
MIRT676571 VSIG1 V-set and immunoglobulin domain containing 1 2 2
MIRT676588 RDH13 retinol dehydrogenase 13 2 2
MIRT676648 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT676723 METTL14 methyltransferase like 14 2 2
MIRT676805 RILPL1 Rab interacting lysosomal protein like 1 2 2
MIRT676813 SHROOM4 shroom family member 4 2 2
MIRT677204 MURC caveolae associated protein 4 2 2
MIRT677284 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT677359 POC1A POC1 centriolar protein A 2 2
MIRT677516 SLC10A6 solute carrier family 10 member 6 2 2
MIRT677530 OCIAD2 OCIA domain containing 2 2 2
MIRT677627 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT677669 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT678056 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT678132 METTL21A methyltransferase like 21A 2 2
MIRT678154 SLC4A4 solute carrier family 4 member 4 2 2
MIRT678463 GLYAT glycine-N-acyltransferase 2 2
MIRT678614 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT678716 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT679161 ZDHHC15 zinc finger DHHC-type containing 15 2 2
MIRT679307 SSBP2 single stranded DNA binding protein 2 2 2
MIRT679430 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT679499 ZNF106 zinc finger protein 106 2 2
MIRT679963 VTA1 vesicle trafficking 1 2 2
MIRT679983 E2F2 E2F transcription factor 2 2 2
MIRT680153 TOP3A DNA topoisomerase III alpha 2 2
MIRT680304 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT680330 LRRC58 leucine rich repeat containing 58 2 2
MIRT680401 OXA1L OXA1L, mitochondrial inner membrane protein 2 2
MIRT683911 PSMB9 proteasome subunit beta 9 2 2
MIRT684183 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT684238 C20orf144 chromosome 20 open reading frame 144 2 2
MIRT684284 CDK9 cyclin dependent kinase 9 2 2
MIRT685411 C1orf158 chromosome 1 open reading frame 158 2 2
MIRT686260 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT688250 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT688327 FAM151B family with sequence similarity 151 member B 2 2
MIRT688747 CNDP1 carnosine dipeptidase 1 2 2
MIRT689040 ANGPTL3 angiopoietin like 3 2 2
MIRT692525 PARD3 par-3 family cell polarity regulator 2 2
MIRT692984 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT699866 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT699877 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT700840 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT701538 NCKAP1 NCK associated protein 1 2 2
MIRT703683 FAM189B family with sequence similarity 189 member B 2 2
MIRT708555 SPA17 sperm autoantigenic protein 17 2 2
MIRT708579 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708721 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT708984 CABP4 calcium binding protein 4 2 2
MIRT709195 SAPCD2 suppressor APC domain containing 2 2 2
MIRT709679 PCDH17 protocadherin 17 2 2
MIRT709962 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT710173 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT710329 STK40 serine/threonine kinase 40 2 2
MIRT710532 TMEM201 transmembrane protein 201 2 2
MIRT710628 ASB7 ankyrin repeat and SOCS box containing 7 2 2
MIRT711037 RNF187 ring finger protein 187 2 2
MIRT711227 RETSAT retinol saturase 2 2
MIRT711418 RAB3C RAB3C, member RAS oncogene family 2 2
MIRT711469 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT711636 PEBP1 phosphatidylethanolamine binding protein 1 2 2
MIRT711658 RAB21 RAB21, member RAS oncogene family 2 2
MIRT711704 GMPR guanosine monophosphate reductase 2 2
MIRT711924 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT712061 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT712094 TMEM218 transmembrane protein 218 2 2
MIRT712541 CYB561D1 cytochrome b561 family member D1 2 2
MIRT714480 TBL2 transducin beta like 2 2 2
MIRT716323 SIGLEC10 sialic acid binding Ig like lectin 10 2 2
MIRT716750 C19orf24 chromosome 19 open reading frame 24 2 2
MIRT717014 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT717162 SHB SH2 domain containing adaptor protein B 2 2
MIRT717369 EDN2 endothelin 2 2 2
MIRT717481 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT718080 CLIC5 chloride intracellular channel 5 2 2
MIRT718545 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT718835 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT718864 LRSAM1 leucine rich repeat and sterile alpha motif containing 1 2 2
MIRT719149 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719687 ALDH1L2 aldehyde dehydrogenase 1 family member L2 2 2
MIRT719780 ZNF236 zinc finger protein 236 2 2
MIRT719859 KLF2 Kruppel like factor 2 2 2
MIRT720496 TMEM178B transmembrane protein 178B 2 2
MIRT720804 NUDT5 nudix hydrolase 5 2 2
MIRT720944 PPP1R3E protein phosphatase 1 regulatory subunit 3E 2 2
MIRT721344 LIF LIF, interleukin 6 family cytokine 2 2
MIRT721805 GRM1 glutamate metabotropic receptor 1 2 2
MIRT721924 LINGO2 leucine rich repeat and Ig domain containing 2 2 2
MIRT722429 HRNR hornerin 2 2
MIRT723971 GPR146 G protein-coupled receptor 146 2 2
MIRT724225 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 2 2
MIRT724272 HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 2 2
MIRT724659 PXDN peroxidasin 2 2
MIRT725282 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
MIRT725434 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT725604 CAPN6 calpain 6 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-660 4-hydroxynonenal NULL 5283344 Microarray human leukemic HL-60 cell 19022373 2009 up-regulated
miR-660 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-660 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-660 Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-660 Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-mir-660 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-660 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-660 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-660 Cisplatin 5460033 NSC119875 approved resistant cell line (KYSE)
hsa-mir-660 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-660 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-660 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-660-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-660-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-660-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-660-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-660-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-660-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-660-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)

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