pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol CSGALNACT1   
Synonyms CSGalNAcT-1, ChGn, beta4GalNAcT
Description chondroitin sulfate N-acetylgalactosaminyltransferase 1
Transcript NM_001130518   
Other Transcripts NM_018371   
Expression
Putative miRNA Targets on CSGALNACT1
3'UTR of CSGALNACT1
(miRNA target sites are highlighted)
>CSGALNACT1|NM_001130518|3'UTR
   1 ACTCCCAGAGAAGGATTGTGGGAGACACTTTTTCTTTCCTTTTGCAATTACTGAAAGTGGCTGCAACAGAGAAAAGACTT
  81 CCATAAAGGACGACAAAAGAATTGGACTGATGGGTCAGAGATGAGAAAGCCTCCGATTTCTCTCTGTTGGGCTTTTTACA
 161 ACAGAAATCAAAATCTCCGCTTTGCCTGCAAAAGTAACCCAGTTGCACCCTGTGAAGTGTCTGACAAAGGCAGAATGCTT
 241 GTGAGATTATAAGCCTAATGGTGTGGAGGTTTTGATGGTGTTTACAACACACTGAGACCTGTTGTTTTGTGTGCTCATTG
 321 AAATATTCATGATTTAAGAGCAGTTTTGTAAAAAATTCATTAGCATGAAAGGCAAGCATATTTCTCCTCATATGAATGAG
 401 CCTATCAGCAGGGCTCTAGTTTCTAGGAATGCTAAAATATCAGAAGGCAGGAGAGGAGATAGGCTTATTATGATACTAGT
 481 GAGTACATTAAGTAAAATAAAATGGACCAGAAAAGAAAAGAAACCATAAATATCGTGTCATATTTTCCCCAAGATTAACC
 561 AAAAATAATCTGCTTATCTTTTTGGTTGTCCTTTTAACTGTCTCCGTTTTTTTCTTTTATTTAAAAATGCACTTTTTTTC
 641 CCTTGTGAGTTATAGTCTGCTTATTTAATTACCACTTTGCAAGCCTTACAAGAGAGCACAAGTTGGCCTACATTTTTATA
 721 TTTTTTAAGAAGATACTTTGAGATGCATTATGAGAACTTTCAGTTCAAAGCATCAAATTGATGCCATATCCAAGGACATG
 801 CCAAATGCTGATTCTGTCAGGCACTGAATGTCAGGCATTGAGACATAGGGAAGGAATGGTTTGTACTAATACAGACGTAC
 881 AGATACTTTCTCTGAAGAGTATTTTCGAAGAGGAGCAACTGAACACTGGAGGAAAAGAAAATGACACTTTCTGCTTTACA
 961 GAAAAGGAAACTCATTCAGACTGGTGATATCGTGATGTACCTAAAAGTCAGAAACCACATTTTCTCCTCAGAAGTAGGGA
1041 CCGCTTTCTTACCTGTTTAAATAAACCAAAGTATACCGTGTGAACCAAACAATCTCTTTTCAAAACAGGGTGCTCCTCCT
1121 GGCTTCTGGCTTCCATAAGAAGAAATGGAGAAAAAAATATATATATATATATTGTGAAAGATCAATCCATCTGCCAGAAT
1201 CTAGTGGGATGGAAGTTTTTGCTACATGTTATCCACCCCAGGCCAGGTGGAAGTAACTGAATTATTTTTTAAATTAAGCA
1281 GTTCTACTCGATCACCAAGATGCTTCTGAAAATTGCATTTTATTACCATTTCAAACTATTTTTTAAAAATAAATACAGTT
1361 AACATAGAGTGGTTTCTTCATTCATGTGAAAATTATTAGCCAGCACCAGATGCATGAGCTAATTATCTCTTTGAGTCCTT
1441 GCTTCTGTTTGCTCACAGTAAACTCATTGTTTAAAAGCTTCAAGAACATTCAAGCTGTTGGTGTGTTAAAAAATGCATTG
1521 TATTGATTTGTACTGGTAGTTTATGAAATTTAATTAAAACACAGGCCATGAATGGAAGGTGGTATTGCACAGCTAATAAA
1601 ATATGATTTGTGGATATGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaguuccaggcgacACUUGUGc 5'
                        ||||||| 
Target 5' cgaagaggagcaacTGAACACt 3'
906 - 927 140.00 -10.30
2
miRNA  3' uaGUUCCA---GGCGACACUUGugc 5'
            ||| ||   ||| |||||||   
Target 5' acCAAAGTATACCG-TGTGAACcaa 3'
1065 - 1088 127.00 -12.72
3
miRNA  3' uaGUUCCAGGCGACACUUGUGc 5'
            :| | | | : ||||::|| 
Target 5' atTATGATAC-TAGTGAGTACa 3'
467 - 487 115.00 -8.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30113767 34 COSMIC
COSN1084577 36 COSMIC
COSN30482130 39 COSMIC
COSN31592036 53 COSMIC
COSN31509432 76 COSMIC
COSN31526201 76 COSMIC
COSN31538745 91 COSMIC
COSN31856149 111 COSMIC
COSN32078515 152 COSMIC
COSN30115351 175 COSMIC
COSN24587410 378 COSMIC
COSN1362315 875 COSMIC
COSN16798755 1024 COSMIC
COSN29604708 1151 COSMIC
COSN19660904 1154 COSMIC
COSN17038125 1156 COSMIC
COSN20105254 1156 COSMIC
COSN6518286 1173 COSMIC
COSN2268883 1190 COSMIC
COSN8576018 1570 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs766161165 3 dbSNP
rs762502764 4 dbSNP
rs1223837945 6 dbSNP
rs149973638 8 dbSNP
rs755074556 14 dbSNP
rs768980210 17 dbSNP
rs761314214 18 dbSNP
rs775705530 21 dbSNP
rs772537037 22 dbSNP
rs746051125 24 dbSNP
rs779071663 25 dbSNP
rs1408708638 26 dbSNP
rs771167052 27 dbSNP
rs1235475954 29 dbSNP
rs753965541 29 dbSNP
rs749311926 31 dbSNP
rs777893668 32 dbSNP
rs755989393 33 dbSNP
rs1170994679 34 dbSNP
rs538811239 35 dbSNP
rs1420248207 37 dbSNP
rs1425295640 38 dbSNP
rs752725076 39 dbSNP
rs1463655789 40 dbSNP
rs1414880364 42 dbSNP
rs780815271 47 dbSNP
rs1403543812 48 dbSNP
rs1482778156 52 dbSNP
rs754762274 54 dbSNP
rs1416599643 56 dbSNP
rs1211931062 58 dbSNP
rs1031654903 60 dbSNP
rs977533246 61 dbSNP
rs1400970123 62 dbSNP
rs751422094 64 dbSNP
rs530782051 69 dbSNP
rs762698549 72 dbSNP
rs749949854 76 dbSNP
rs766591802 76 dbSNP
rs764862226 78 dbSNP
rs1345668231 81 dbSNP
rs761065402 82 dbSNP
rs776105829 89 dbSNP
rs772490962 91 dbSNP
rs759850175 92 dbSNP
rs774714671 94 dbSNP
rs771077264 95 dbSNP
rs562164666 96 dbSNP
rs777805509 102 dbSNP
rs769952079 104 dbSNP
rs542301240 109 dbSNP
rs781134539 111 dbSNP
rs754884146 114 dbSNP
rs1191862903 116 dbSNP
rs181163485 119 dbSNP
rs1479307623 120 dbSNP
rs1466088504 122 dbSNP
rs1028023066 125 dbSNP
rs553600071 134 dbSNP
rs758112104 135 dbSNP
rs113643413 146 dbSNP
rs1358882919 150 dbSNP
rs764623053 151 dbSNP
rs756754827 159 dbSNP
rs760854585 160 dbSNP
rs1035956886 161 dbSNP
rs987778672 169 dbSNP
rs944475895 170 dbSNP
rs1367882760 172 dbSNP
rs890161740 178 dbSNP
rs1034647666 179 dbSNP
rs538015064 180 dbSNP
rs1174776225 183 dbSNP
rs1464619569 184 dbSNP
rs1377071558 185 dbSNP
rs577450036 188 dbSNP
rs189316656 189 dbSNP
rs1204143406 190 dbSNP
rs537851803 194 dbSNP
rs1187662123 199 dbSNP
rs897919544 200 dbSNP
rs1036415463 202 dbSNP
rs766776951 203 dbSNP
rs1198605653 207 dbSNP
rs1343682641 210 dbSNP
rs139522958 211 dbSNP
rs1440788244 212 dbSNP
rs764703633 217 dbSNP
rs1230239472 218 dbSNP
rs1378816907 219 dbSNP
rs184388355 220 dbSNP
rs1295918536 222 dbSNP
rs890498898 229 dbSNP
rs1434851077 232 dbSNP
rs769929993 233 dbSNP
rs535176268 237 dbSNP
rs1226059222 240 dbSNP
rs1393124725 241 dbSNP
rs748200813 250 dbSNP
rs1401658083 251 dbSNP
rs761119052 258 dbSNP
rs1431905256 259 dbSNP
rs1024429976 260 dbSNP
rs991566749 263 dbSNP
rs1238047349 270 dbSNP
rs1050407722 276 dbSNP
rs958809363 280 dbSNP
rs1445033162 283 dbSNP
rs1027475344 286 dbSNP
rs1238922412 287 dbSNP
rs3802330 288 dbSNP
rs1441759306 290 dbSNP
rs1250678896 291 dbSNP
rs1206647132 292 dbSNP
rs1339401378 294 dbSNP
rs1273479493 301 dbSNP
rs767259757 304 dbSNP
rs1246166915 308 dbSNP
rs1236864255 309 dbSNP
rs768709108 311 dbSNP
rs1286305657 312 dbSNP
rs1386876370 313 dbSNP
rs546376202 316 dbSNP
rs897715407 318 dbSNP
rs1340360698 319 dbSNP
rs28679276 320 dbSNP
rs1411767447 323 dbSNP
rs1347405988 325 dbSNP
rs1043969342 329 dbSNP
rs1008485972 330 dbSNP
rs1401069877 333 dbSNP
rs1368723566 334 dbSNP
rs890114294 335 dbSNP
rs1307664074 338 dbSNP
rs1163301932 341 dbSNP
rs765403543 343 dbSNP
rs370322181 346 dbSNP
rs1333338674 347 dbSNP
rs1425531725 348 dbSNP
rs1386003601 350 dbSNP
rs1415772183 355 dbSNP
rs946541139 358 dbSNP
rs193150319 359 dbSNP
rs1364348830 361 dbSNP
rs1323170130 362 dbSNP
rs1184178406 377 dbSNP
rs1242116834 378 dbSNP
rs550551481 379 dbSNP
rs1481787350 381 dbSNP
rs987891918 386 dbSNP
rs1247676210 390 dbSNP
rs1250415924 391 dbSNP
rs995923934 393 dbSNP
rs1199974251 401 dbSNP
rs758308420 404 dbSNP
rs900029104 406 dbSNP
rs1208463389 407 dbSNP
rs745690869 408 dbSNP
rs1480551896 412 dbSNP
rs1289540366 413 dbSNP
rs766769054 414 dbSNP
rs1230705075 419 dbSNP
rs927662539 427 dbSNP
rs1187550232 430 dbSNP
rs1219361332 431 dbSNP
rs980387210 432 dbSNP
rs778582347 433 dbSNP
rs1437523084 437 dbSNP
rs970064370 440 dbSNP
rs1351805992 446 dbSNP
rs1321788743 447 dbSNP
rs1404577731 449 dbSNP
rs1385313861 463 dbSNP
rs756878280 464 dbSNP
rs530941442 470 dbSNP
rs1303247964 472 dbSNP
rs1358085501 472 dbSNP
rs1027878909 475 dbSNP
rs936270889 477 dbSNP
rs995424215 479 dbSNP
rs962199097 481 dbSNP
rs1219935620 484 dbSNP
rs562052718 488 dbSNP
rs1307445222 491 dbSNP
rs796155290 492 dbSNP
rs924818617 498 dbSNP
rs1199468779 508 dbSNP
rs1478701073 510 dbSNP
rs1041984241 511 dbSNP
rs114059476 513 dbSNP
rs1264176733 514 dbSNP
rs1451397363 516 dbSNP
rs917235403 519 dbSNP
rs992011577 520 dbSNP
rs958786921 522 dbSNP
rs1327677687 523 dbSNP
rs1267633660 524 dbSNP
rs899760614 524 dbSNP
rs1219922299 525 dbSNP
rs755452762 526 dbSNP
rs752098184 530 dbSNP
rs920439101 532 dbSNP
rs1366239207 534 dbSNP
rs766899452 535 dbSNP
rs1365731682 547 dbSNP
rs962274949 548 dbSNP
rs1014830694 550 dbSNP
rs35602840 551 dbSNP
rs1455611650 553 dbSNP
rs1043615202 556 dbSNP
rs1008767543 560 dbSNP
rs1387853168 565 dbSNP
rs1219281757 566 dbSNP
rs1176641174 567 dbSNP
rs954403968 570 dbSNP
rs1028604827 571 dbSNP
rs1415694442 573 dbSNP
rs1310890292 574 dbSNP
rs1422366546 576 dbSNP
rs1190338422 577 dbSNP
rs946543412 579 dbSNP
rs1287132976 580 dbSNP
rs1489412538 585 dbSNP
rs1249089476 586 dbSNP
rs1214776144 587 dbSNP
rs1190876330 590 dbSNP
rs996342353 598 dbSNP
rs913772330 601 dbSNP
rs1463795599 602 dbSNP
rs1247980619 605 dbSNP
rs773909749 606 dbSNP
rs1055036647 610 dbSNP
rs1000336177 612 dbSNP
rs763251077 613 dbSNP
rs1218910187 614 dbSNP
rs1452432052 614 dbSNP
rs1172802007 619 dbSNP
rs1380635177 622 dbSNP
rs1343096571 624 dbSNP
rs756501326 625 dbSNP
rs1300045971 626 dbSNP
rs189291569 628 dbSNP
rs1344224597 633 dbSNP
rs1436655738 634 dbSNP
rs770413752 637 dbSNP
rs950267281 638 dbSNP
rs750786734 640 dbSNP
rs939127622 640 dbSNP
rs560022337 641 dbSNP
rs927694887 642 dbSNP
rs748749190 645 dbSNP
rs1450124059 653 dbSNP
rs1283914044 656 dbSNP
rs1322488996 659 dbSNP
rs1223875880 660 dbSNP
rs546393617 669 dbSNP
rs1174721691 675 dbSNP
rs1430049867 677 dbSNP
rs1391668525 678 dbSNP
rs75608572 679 dbSNP
rs776760417 680 dbSNP
rs920654482 687 dbSNP
rs1261457803 689 dbSNP
rs557644037 693 dbSNP
rs1484510698 694 dbSNP
rs973889366 699 dbSNP
rs1209542545 700 dbSNP
rs1483394379 701 dbSNP
rs747914570 704 dbSNP
rs1277051888 705 dbSNP
rs1226373472 706 dbSNP
rs1341280776 708 dbSNP
rs1391704413 711 dbSNP
rs1439495565 712 dbSNP
rs1313146628 720 dbSNP
rs768057459 732 dbSNP
rs920848602 734 dbSNP
rs1376849078 735 dbSNP
rs1224002808 736 dbSNP
rs1302155616 745 dbSNP
rs1409931554 746 dbSNP
rs768907520 751 dbSNP
rs1230197142 752 dbSNP
rs1339455288 752 dbSNP
rs1250412151 759 dbSNP
rs961893574 761 dbSNP
rs1227781783 766 dbSNP
rs142287827 768 dbSNP
rs1179424164 771 dbSNP
rs1372914203 773 dbSNP
rs1309610177 774 dbSNP
rs907698524 776 dbSNP
rs1299694627 777 dbSNP
rs28611342 778 dbSNP
rs1346640836 785 dbSNP
rs775528602 789 dbSNP
rs1187784775 793 dbSNP
rs772161859 796 dbSNP
rs1254063797 798 dbSNP
rs954600547 800 dbSNP
rs1029094693 801 dbSNP
rs995819223 804 dbSNP
rs1203352761 806 dbSNP
rs958036000 808 dbSNP
rs1460528677 811 dbSNP
rs1032130472 814 dbSNP
rs1265855266 815 dbSNP
rs554923829 824 dbSNP
rs1223538369 832 dbSNP
rs1319652414 833 dbSNP
rs1170697572 835 dbSNP
rs999662793 837 dbSNP
rs369198221 838 dbSNP
rs575268155 838 dbSNP
rs987617275 838 dbSNP
rs954793959 842 dbSNP
rs745623011 846 dbSNP
rs1029052752 848 dbSNP
rs1450603131 850 dbSNP
rs1020435702 851 dbSNP
rs1355054986 858 dbSNP
rs1014530711 859 dbSNP
rs1391040026 860 dbSNP
rs1294871237 863 dbSNP
rs138952542 870 dbSNP
rs1348432605 872 dbSNP
rs996587499 874 dbSNP
rs756932638 876 dbSNP
rs748939438 877 dbSNP
rs777231514 879 dbSNP
rs1010853470 881 dbSNP
rs1414346106 885 dbSNP
rs892366358 887 dbSNP
rs1474645561 890 dbSNP
rs1180069194 893 dbSNP
rs1418540243 895 dbSNP
rs1268349717 896 dbSNP
rs572622031 897 dbSNP
rs1193080541 898 dbSNP
rs1056205495 900 dbSNP
rs1463763240 901 dbSNP
rs939161652 905 dbSNP
rs781004107 906 dbSNP
rs1331091921 907 dbSNP
rs1479997905 910 dbSNP
rs11552379 911 dbSNP
rs1266118838 913 dbSNP
rs1227266958 916 dbSNP
rs1331119539 918 dbSNP
rs1302959632 919 dbSNP
rs1403516539 919 dbSNP
rs1384711316 921 dbSNP
rs1435556718 922 dbSNP
rs552767957 925 dbSNP
rs1195990076 926 dbSNP
rs1325625382 932 dbSNP
rs1458267432 936 dbSNP
rs1044783105 942 dbSNP
rs1037814010 945 dbSNP
rs1280302921 947 dbSNP
rs1324813025 947 dbSNP
rs940768027 950 dbSNP
rs1391512105 951 dbSNP
rs907729551 953 dbSNP
rs539621058 961 dbSNP
rs570510406 973 dbSNP
rs920306035 978 dbSNP
rs866493520 979 dbSNP
rs1178594947 988 dbSNP
rs973463530 989 dbSNP
rs1252185645 990 dbSNP
rs550891197 991 dbSNP
rs758910219 992 dbSNP
rs1246128314 996 dbSNP
rs1204410103 998 dbSNP
rs537338293 999 dbSNP
rs1345193484 1001 dbSNP
rs1257230654 1002 dbSNP
rs750793117 1016 dbSNP
rs1311219684 1018 dbSNP
rs765576788 1026 dbSNP
rs975058574 1027 dbSNP
rs1436308831 1033 dbSNP
rs184553312 1034 dbSNP
rs548585269 1039 dbSNP
rs1382156637 1041 dbSNP
rs1032409308 1042 dbSNP
rs1383071046 1043 dbSNP
rs1329663088 1044 dbSNP
rs1393243009 1048 dbSNP
rs1331637131 1052 dbSNP
rs1442955502 1053 dbSNP
rs1304624722 1054 dbSNP
rs977849024 1061 dbSNP
rs1464570788 1071 dbSNP
rs1346940371 1076 dbSNP
rs1240583168 1077 dbSNP
rs116759812 1078 dbSNP
rs764442353 1080 dbSNP
rs1020465146 1086 dbSNP
rs1388077772 1091 dbSNP
rs1029493551 1092 dbSNP
rs1442902800 1093 dbSNP
rs1257719081 1096 dbSNP
rs1252908458 1101 dbSNP
rs1440771570 1101 dbSNP
rs1198253660 1104 dbSNP
rs760789514 1106 dbSNP
rs1274912844 1109 dbSNP
rs1014396444 1110 dbSNP
rs775010744 1111 dbSNP
rs969195944 1112 dbSNP
rs1021651922 1113 dbSNP
rs1323877352 1114 dbSNP
rs1363189477 1119 dbSNP
rs1370153737 1120 dbSNP
rs1227410119 1121 dbSNP
rs559907777 1122 dbSNP
rs1336678702 1129 dbSNP
rs779017204 1134 dbSNP
rs775728881 1135 dbSNP
rs1265640330 1139 dbSNP
rs1374867814 1142 dbSNP
rs552349198 1145 dbSNP
rs1431857266 1146 dbSNP
rs1368516783 1147 dbSNP
rs1167083560 1148 dbSNP
rs1472975331 1150 dbSNP
rs1202712193 1151 dbSNP
rs772072131 1152 dbSNP
rs1185240166 1153 dbSNP
rs532782845 1154 dbSNP
rs1207348533 1155 dbSNP
rs766710235 1155 dbSNP
rs35704904 1156 dbSNP
rs57082500 1156 dbSNP
rs34647465 1157 dbSNP
rs66526055 1157 dbSNP
rs1420280964 1158 dbSNP
rs1491585515 1158 dbSNP
rs548241999 1158 dbSNP
rs746903152 1158 dbSNP
rs780902186 1158 dbSNP
rs1003336312 1160 dbSNP
rs1251887003 1160 dbSNP
rs1350535687 1160 dbSNP
rs1280664534 1161 dbSNP
rs1206931112 1162 dbSNP
rs758304801 1163 dbSNP
rs1481848363 1165 dbSNP
rs1271796059 1167 dbSNP
rs1241195497 1168 dbSNP
rs1195622584 1169 dbSNP
rs1357420387 1171 dbSNP
rs1286484059 1172 dbSNP
rs34024297 1172 dbSNP
rs1038079788 1173 dbSNP
rs3840719 1173 dbSNP
rs757717411 1174 dbSNP
rs1231986982 1176 dbSNP
rs544124721 1179 dbSNP
rs7005528 1185 dbSNP
rs1411960634 1201 dbSNP
rs1334223850 1202 dbSNP
rs947856492 1203 dbSNP
rs1405742738 1211 dbSNP
rs1474316864 1214 dbSNP
rs1392541780 1219 dbSNP
rs1187342636 1222 dbSNP
rs1424375046 1226 dbSNP
rs1161447659 1230 dbSNP
rs886486345 1233 dbSNP
rs1406506023 1234 dbSNP
rs1338411006 1237 dbSNP
rs1412112482 1238 dbSNP
rs1183749940 1239 dbSNP
rs1471303897 1246 dbSNP
rs1231962793 1259 dbSNP
rs1398761347 1271 dbSNP
rs898890790 1278 dbSNP
rs561215350 1281 dbSNP
rs940307128 1289 dbSNP
rs908132467 1290 dbSNP
rs987682608 1292 dbSNP
rs1051555335 1295 dbSNP
rs1212412049 1295 dbSNP
rs1334742035 1296 dbSNP
rs1269264877 1299 dbSNP
rs1230339323 1301 dbSNP
rs777352677 1303 dbSNP
rs1279200157 1306 dbSNP
rs769447265 1314 dbSNP
rs1332676943 1315 dbSNP
rs1323604750 1316 dbSNP
rs747590058 1318 dbSNP
rs1282855228 1320 dbSNP
rs78627047 1321 dbSNP
rs530234302 1330 dbSNP
rs762157206 1332 dbSNP
rs1406594560 1333 dbSNP
rs758930870 1338 dbSNP
rs1478789557 1340 dbSNP
rs1248870356 1344 dbSNP
rs1192174530 1345 dbSNP
rs1468286816 1350 dbSNP
rs1249193584 1356 dbSNP
rs1211062697 1357 dbSNP
rs1315259410 1358 dbSNP
rs750940895 1361 dbSNP
rs1432602272 1364 dbSNP
rs1172694627 1367 dbSNP
rs1286554083 1367 dbSNP
rs566512247 1367 dbSNP
rs968849810 1368 dbSNP
rs779306539 1378 dbSNP
rs1446794875 1382 dbSNP
rs757524016 1384 dbSNP
rs1442232464 1386 dbSNP
rs1285576799 1388 dbSNP
rs1233302593 1391 dbSNP
rs1365590394 1392 dbSNP
rs1322538602 1395 dbSNP
rs1306230519 1399 dbSNP
rs572456370 1401 dbSNP
rs936555705 1404 dbSNP
rs1334224047 1405 dbSNP
rs1368170675 1407 dbSNP
rs368106336 1407 dbSNP
rs547308937 1407 dbSNP
rs754253829 1412 dbSNP
rs764356650 1414 dbSNP
rs1035653759 1415 dbSNP
rs760984516 1421 dbSNP
rs796235789 1422 dbSNP
rs1023489580 1433 dbSNP
rs540162753 1433 dbSNP
rs924989741 1437 dbSNP
rs1191124411 1445 dbSNP
rs1485159535 1446 dbSNP
rs562936755 1447 dbSNP
rs1037821766 1454 dbSNP
rs1344132960 1456 dbSNP
rs1241642620 1463 dbSNP
rs1461487660 1464 dbSNP
rs1004552901 1465 dbSNP
rs1295694417 1467 dbSNP
rs1210934444 1470 dbSNP
rs752824226 1472 dbSNP
rs767766982 1474 dbSNP
rs553039039 1476 dbSNP
rs1342697231 1488 dbSNP
rs1274985464 1489 dbSNP
rs1299508692 1490 dbSNP
rs1363127895 1491 dbSNP
rs1212787648 1493 dbSNP
rs1192800658 1494 dbSNP
rs1233205989 1495 dbSNP
rs1162329090 1496 dbSNP
rs1361212580 1498 dbSNP
rs1284668475 1502 dbSNP
rs1449589066 1507 dbSNP
rs763429382 1508 dbSNP
rs1311950116 1514 dbSNP
rs1406776553 1514 dbSNP
rs1424766789 1514 dbSNP
rs1475250960 1516 dbSNP
rs1429993177 1517 dbSNP
rs1371598730 1521 dbSNP
rs1166395741 1523 dbSNP
rs1386640156 1525 dbSNP
rs1172957539 1528 dbSNP
rs1024763312 1529 dbSNP
rs1461341335 1532 dbSNP
rs1427055182 1534 dbSNP
rs1419434740 1537 dbSNP
rs1165864314 1538 dbSNP
rs1475285457 1539 dbSNP
rs1182896832 1556 dbSNP
rs1330103834 1560 dbSNP
rs7001231 1561 dbSNP
rs1255490533 1562 dbSNP
rs532321542 1565 dbSNP
rs1210489300 1568 dbSNP
rs577012605 1574 dbSNP
rs960260848 1577 dbSNP
rs1276979377 1579 dbSNP
rs373884795 1581 dbSNP
rs1279264169 1582 dbSNP
rs1306637796 1583 dbSNP
rs774111927 1587 dbSNP
rs1356267894 1592 dbSNP
rs1290524469 1593 dbSNP
rs1229945543 1595 dbSNP
rs1195918633 1600 dbSNP
rs1291465628 1600 dbSNP
rs141955684 1601 dbSNP
rs1353095276 1605 dbSNP
rs1034920405 1619 dbSNP
rs1292096758 1620 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 55790.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000454498.2 | 3UTR | CACUGGAGGAAAAGAAAAUGACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.684 1.1e-4 -0.672 1.6e-4 24 Click to see details
GSE28260 Renal cortex and medulla 0.7 3.9e-3 0.533 3.0e-2 13 Click to see details
GSE32688 Pancreatic cancer 0.327 3.4e-2 0.270 6.8e-2 32 Click to see details
GSE21687 Ependynoma primary tumors 0.219 4.1e-2 0.170 9.0e-2 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.359 4.6e-2 -0.255 1.2e-1 23 Click to see details
GSE38226 Liver fibrosis 0.283 1.1e-1 0.403 3.5e-2 21 Click to see details
GSE19350 CNS germ cell tumors 0.278 1.9e-1 0.434 7.9e-2 12 Click to see details
GSE17498 Multiple myeloma -0.088 2.9e-1 -0.006 4.9e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.102 3.2e-1 0.190 1.9e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.039 4.3e-1 -0.035 4.3e-1 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.013 4.8e-1 -0.576 3.9e-3 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.013 4.8e-1 -0.576 3.9e-3 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
-0.013 4.8e-1 -0.576 3.9e-3 20 Click to see details
-0.013 4.8e-1 -0.576 3.9e-3 20 Click to see details
-0.013 4.8e-1 -0.576 3.9e-3 20 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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