miRTarBase - #MIRT538879


—
pre-miRNA Information
pre-miRNA hsa-mir-4471   
Genomic Coordinates chr8: 100382763 - 100382845
Description Homo sapiens miR-4471 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4471
Sequence 49| UGGGAACUUAGUAGAGGUUUAA |70
Evidence Experimental
Experiments Illumina
Putative Targets

Gene Information
Gene Symbol BTBD1   
Synonyms C15orf1, NS5ATP8
Description BTB domain containing 1
Transcript NM_001011885   
Other Transcripts NM_025238   
Expression
Putative miRNA Targets on BTBD1
3'UTR of BTBD1
(miRNA target sites are highlighted)		 
>BTBD1|NM_001011885|3'UTR
   1 AGATCCTGCCCAATGTGTGCTACACAGCATGTGCAACACTCAAAGGTCCAGATTCCCACTATGGCACAAAAGGATTGAAG
  81 AAAGTAGTGCATGAGACACCTGCTGCAAGCAAGACTGTTTTTTTCTTTTTTAGTTCCCCTGGCAATAATAATGGCACTTC
 161 AATAGAAGATGGACAAATTCCAGAAATCATATTTTATACATAATTTAGCATTATAATACATCTTGGCTAAATAATACCAT
 241 ACAATCTAGTGTCAAAAACATAAATGGCCACAAAAAAGTAGTTTGAGTGTTATGAATATTTAAAATTGTAAGATAAGAAA
 321 CAGTTTCTTAGAGCAGATAGAAAAATGCTTATTTAAATCTTTGCATGATTTAAAAACAGATTTTCCATTTTCTTACAACT
 401 TTAAGAGAAAAGAACTGGGTTTAATGGTTTAAAAAAAAGCACAGCTTTTTCACCTTCATCTTGTATAATTTCATAGATTG
 481 GCTGACTTAGGGTCTTTCAATAGTTTGGGAATTGAAAGATTCTTGTTATATATAGCTAGTTTGGGTTTGTTTTTGTTTTA
 561 ACTATTTTGAAGGTTAGGTGAGATGGGCAAATAGGCTTAACTATTTTGAAGGTTGGATGAAAAGAGATGGGTCAGTATTC
 641 CTACAGAATTCTTATTAACTCAAATAACTAAATTTCAGAAAATTAAGAAGCTGACTTTATATTTGGTGGTTTGAAGTATC
 721 TTGTTGTTAGCATTTGTAATAATGCTAAAAAAGGCCTAATAAAATGCCCAAGAAAATATTCAGTGCATTTATAGAGAAGG
 801 ATATTTTGTAGTAGTATAGTAATGTGTTATGTAGTACAGTTTTAAAGCTATAAATGGAATTTTGTGTAAATTCACAAAAA
 881 TGTGATATAAACAGGATCTAAGACTGGATTCCCTGTCACTAAACTGCACCACTATACCTGTCTCTCTGTGTGGGGGACAC
 961 TGCTGATGATTCCCAAGATTGAGATGATGACGGTGATGACGACTGGGTGAACAGCCATCACTTCAACATTGTGATAATCC
1041 TTCACAGCAAGAAACCGAATAAAATACTAACATTTCTAACAACTGCTCTGACATTGTAAAGAGATCCAACAGAATCACTC
1121 CTGCTGAAAAATACGCTTTCTGCCACCTACACATTTCTATTTAGGAAGTAAAATTTGCTTCATGGTCATGACCCCATTAG
1201 TCAGTGTTACAGCTGTGTTGGGGATAGGAAGTATATCTGGCAGATTGATATTTATACACTTTTTTATAAAGCAGATTTTA
1281 AAATATAGTAACATCCATTTTTTTCCCTTGAAAGTGATTCTCTTATAAAAAATGAAAGTGGAGTTTAAGGTATATCAAAT
1361 CGTTGTGGAAGGTGATTAAAAATCAAAATTCTTTTAAATATCAACTTAATTTTTTCTAAGTAAGATACAAAAAATTTTCA
1441 TCTAAAGTAATATTTCACTTTATATTGTAAAGAAGGTAGGTATATTGGTGGCTGAGGTCTCTTGAAATTGCTAAAGGGAA
1521 ATTTTTCTATGGTAATGCTCTTACGGATATAAACCTCAGTTAAATGGAATTATCTATGGGATGTGTGGTTCTGGTTAACT
1601 AAAAATTAACCAGTAAACACTCTGTAGTAACCATTACAGAAAATACTTCTGCCTTAAAAAATATGATATGCCAGAGATGA
1681 GTTAGTGTTTCTTGACGTTGGAGACCTTTTAAATGCCTCATCTGTTGTACTGAACAATTGAAACTGCATGCAGCCATAAA
1761 AGGGACAAGAAACAGAACTGTTTACTAACTTTGGGACATCCCCTGGAGTTTTTAAAAATAAATAAATATATATATATATA
1841 AAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aauuuGGAGAUGAUUCAAGGGu 5'
               :||:| :| ||||||| 
Target 5' tttttTCTTT-TTTAGTTCCCc 3'
 119 - 139 152.00 -12.20
2 
miRNA  3' aaUUUG---GAGA---UGAUUCAAGGGu 5'
            ||||    |||   |||:: ||||| 
Target 5' atAAACAGGATCTAAGACTGGATTCCCt 3'
 887 - 914 116.00 -16.30
3 
miRNA  3' aauUUG-GAGAU---GAUUC-AAGGGu 5'
             ||| ||| |   :  || ||||| 
Target 5' tgcAACACTCAAAGGTCCAGATTCCCa 3'
 32 - 58 115.00 -9.52
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM6861721 3 COSMIC
COSM8772567 6 COSMIC
COSM1374995 22 COSMIC
COSM9616506 27 COSMIC
COSM7454679 37 COSMIC
COSN23846622 69 COSMIC
COSN30767495 151 COSMIC
COSN1686174 229 COSMIC
COSN7250666 419 COSMIC
COSM5626213 560 COSMIC
COSM9539963 594 COSMIC
COSM7631003 596 COSMIC
COSM6044633 597 COSMIC
COSM2012737 598 COSMIC
COSM1640365 599 COSMIC
COSM7240996 610 COSMIC
COSM8411389 617 COSMIC
COSM4806256 632 COSMIC
COSM9471265 633 COSMIC
COSM6214786 644 COSMIC
COSM7413002 647 COSMIC
COSM8394143 651 COSMIC
COSM1478407 655 COSMIC
COSM3504616 656 COSMIC
COSN20622647 692 COSMIC
COSN28198202 695 COSMIC
COSN31554946 697 COSMIC
COSN15324379 744 COSMIC
COSN9639870 747 COSMIC
COSN30505261 752 COSMIC
COSN30504441 767 COSMIC
COSN25850692 806 COSMIC
COSN31659454 817 COSMIC
COSN25850691 819 COSMIC
COSN31522453 820 COSMIC
COSN29316798 912 COSMIC
COSN28796873 1169 COSMIC
COSN31578809 1227 COSMIC
COSN31608797 1262 COSMIC
COSN32057244 1269 COSMIC
COSN26852148 1413 COSMIC
COSN24415360 1429 COSMIC
COSN26555990 1567 COSMIC
COSN31513034 1787 COSMIC
COSN29209999 1889 COSMIC
COSN29215203 1890 COSMIC
COSN1686172 2149 COSMIC
COSN20112338 2188 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs149040830 2 dbSNP
rs772514339 3 dbSNP
rs376123965 5 dbSNP
rs1403389137 15 dbSNP
rs1322859836 17 dbSNP
rs11557551 19 dbSNP
rs1350378847 25 dbSNP
rs747190044 34 dbSNP
rs778544522 35 dbSNP
rs1405388050 38 dbSNP
rs1438734433 42 dbSNP
rs754697311 48 dbSNP
rs779667774 49 dbSNP
rs755549700 54 dbSNP
rs750407971 55 dbSNP
rs767308168 57 dbSNP
rs780156164 58 dbSNP
rs1020313594 59 dbSNP
rs1333197936 60 dbSNP
rs199578481 61 dbSNP
rs954046530 67 dbSNP
rs1488142699 68 dbSNP
rs751331989 73 dbSNP
rs763976259 78 dbSNP
rs1486646719 80 dbSNP
rs1260800513 83 dbSNP
rs759894123 87 dbSNP
rs1194150062 90 dbSNP
rs1321312710 90 dbSNP
rs1471717742 93 dbSNP
rs565714115 103 dbSNP
rs1232280561 113 dbSNP
rs554290813 114 dbSNP
rs751661919 145 dbSNP
rs1391407245 146 dbSNP
rs1272285422 147 dbSNP
rs189139370 147 dbSNP
rs1429313496 149 dbSNP
rs150069676 152 dbSNP
rs1019964489 156 dbSNP
rs1400653700 159 dbSNP
rs1300335444 176 dbSNP
rs891595660 178 dbSNP
rs760166254 183 dbSNP
rs1327084384 184 dbSNP
rs184671725 188 dbSNP
rs907107266 189 dbSNP
rs1429560660 197 dbSNP
rs1050514492 208 dbSNP
rs1264916540 213 dbSNP
rs1164538356 220 dbSNP
rs1410713071 222 dbSNP
rs1044722669 233 dbSNP
rs1368892014 234 dbSNP
rs1473651983 245 dbSNP
rs1156816782 247 dbSNP
rs1420042958 249 dbSNP
rs764141158 255 dbSNP
rs552006804 256 dbSNP
rs759513236 260 dbSNP
rs1420404983 272 dbSNP
rs901716868 280 dbSNP
rs1160490244 281 dbSNP
rs1474267899 283 dbSNP
rs1395612263 288 dbSNP
rs531681184 294 dbSNP
rs1342707611 297 dbSNP
rs532295825 298 dbSNP
rs1309241176 303 dbSNP
rs1354993423 303 dbSNP
rs940474885 303 dbSNP
rs1240286091 315 dbSNP
rs569967456 319 dbSNP
rs1342240619 321 dbSNP
rs907694895 324 dbSNP
rs1048758189 330 dbSNP
rs982887233 335 dbSNP
rs1250564408 340 dbSNP
rs931382138 346 dbSNP
rs549688207 350 dbSNP
rs919035606 364 dbSNP
rs1160545564 365 dbSNP
rs972911380 367 dbSNP
rs1465604514 368 dbSNP
rs1438033955 379 dbSNP
rs1404592476 386 dbSNP
rs529946633 392 dbSNP
rs1464415592 394 dbSNP
rs560809811 399 dbSNP
rs1378304582 400 dbSNP
rs912791467 400 dbSNP
rs1299811419 416 dbSNP
rs570548209 422 dbSNP
rs1231858952 426 dbSNP
rs1339095124 437 dbSNP
rs958990764 438 dbSNP
rs1325194194 447 dbSNP
rs1196532627 448 dbSNP
rs1257127798 458 dbSNP
rs527237023 465 dbSNP
rs1021638390 467 dbSNP
rs1368918745 469 dbSNP
rs1432726491 469 dbSNP
rs776693959 475 dbSNP
rs1224083557 476 dbSNP
rs1199613627 480 dbSNP
rs766518196 482 dbSNP
rs1315979565 484 dbSNP
rs1384127623 485 dbSNP
rs981589942 488 dbSNP
rs760628751 500 dbSNP
rs564893568 501 dbSNP
rs772506785 502 dbSNP
rs748653037 506 dbSNP
rs774759737 507 dbSNP
rs768989446 508 dbSNP
rs1371629921 509 dbSNP
rs1476928162 514 dbSNP
rs766256890 514 dbSNP
rs1401560944 516 dbSNP
rs748981779 524 dbSNP
rs1429917298 525 dbSNP
rs144905152 526 dbSNP
rs956103424 533 dbSNP
rs1032203528 534 dbSNP
rs1390582701 541 dbSNP
rs1260939249 543 dbSNP
rs1262057592 544 dbSNP
rs1199363187 546 dbSNP
rs1459559946 548 dbSNP
rs967550327 551 dbSNP
rs114342767 555 dbSNP
rs201425073 564 dbSNP
rs1204159151 565 dbSNP
rs755673294 568 dbSNP
rs868425758 569 dbSNP
rs1278088330 570 dbSNP
rs200566834 574 dbSNP
rs745312065 577 dbSNP
rs1011323509 580 dbSNP
rs781192572 589 dbSNP
rs1312230316 593 dbSNP
rs758495697 595 dbSNP
rs1385008127 598 dbSNP
rs907041442 599 dbSNP
rs1045635 606 dbSNP
rs750539172 606 dbSNP
rs777656407 610 dbSNP
rs757330656 614 dbSNP
rs1277176220 615 dbSNP
rs751528043 620 dbSNP
rs1462851935 626 dbSNP
rs764027565 633 dbSNP
rs758232768 635 dbSNP
rs1442413328 639 dbSNP
rs754118965 643 dbSNP
rs1022846286 644 dbSNP
rs1183727257 660 dbSNP
rs766458245 665 dbSNP
rs760818782 667 dbSNP
rs1206332710 672 dbSNP
rs750538880 676 dbSNP
rs767575976 679 dbSNP
rs1488095553 680 dbSNP
rs1264653061 684 dbSNP
rs1028658990 687 dbSNP
rs756094447 696 dbSNP
rs1315807640 697 dbSNP
rs373426191 700 dbSNP
rs201126475 701 dbSNP
rs769042541 706 dbSNP
rs1392506959 709 dbSNP
rs1390399530 715 dbSNP
rs1305097737 717 dbSNP
rs763181393 718 dbSNP
rs775222265 719 dbSNP
rs769264663 724 dbSNP
rs1163629786 725 dbSNP
rs1469142582 730 dbSNP
rs745529203 733 dbSNP
rs772989747 735 dbSNP
rs17158127 744 dbSNP
rs897553569 758 dbSNP
rs1201943742 759 dbSNP
rs1295788430 765 dbSNP
rs1366971880 766 dbSNP
rs1397554864 770 dbSNP
rs553935846 774 dbSNP
rs1040544365 789 dbSNP
rs1216144953 793 dbSNP
rs1437663725 794 dbSNP
rs760881146 801 dbSNP
rs1245508739 802 dbSNP
rs112228893 803 dbSNP
rs1487375611 804 dbSNP
rs912731751 804 dbSNP
rs985671461 805 dbSNP
rs571280050 808 dbSNP
rs1346321240 809 dbSNP
rs932887290 819 dbSNP
rs1255971403 831 dbSNP
rs1424755359 838 dbSNP
rs914862063 843 dbSNP
rs990139174 844 dbSNP
rs1048917350 853 dbSNP
rs931421883 856 dbSNP
rs956260060 862 dbSNP
rs1375567172 872 dbSNP
rs1360775839 873 dbSNP
rs1432387552 877 dbSNP
rs1300704389 884 dbSNP
rs1378261450 890 dbSNP
rs1317101605 891 dbSNP
rs1396366352 891 dbSNP
rs1351361359 893 dbSNP
rs189317063 893 dbSNP
rs1278052622 895 dbSNP
rs1208365367 896 dbSNP
rs1441714908 898 dbSNP
rs1055817764 912 dbSNP
rs1313249568 919 dbSNP
rs1426365958 920 dbSNP
rs971212466 921 dbSNP
rs1436291157 932 dbSNP
rs1373563294 934 dbSNP
rs1023215773 938 dbSNP
rs537876949 939 dbSNP
rs1401936849 944 dbSNP
rs1400805113 945 dbSNP
rs1012736734 946 dbSNP
rs1466385039 949 dbSNP
rs1409500976 954 dbSNP
rs1175158764 955 dbSNP
rs577225234 957 dbSNP
rs1374585651 958 dbSNP
rs937311727 960 dbSNP
rs887682312 965 dbSNP
rs1375669949 968 dbSNP
rs1217527100 972 dbSNP
rs184980550 977 dbSNP
rs981685007 981 dbSNP
rs1205973764 990 dbSNP
rs1256498670 998 dbSNP
rs1388055137 999 dbSNP
rs542866416 1000 dbSNP
rs1457578359 1010 dbSNP
rs1199863465 1013 dbSNP
rs967603152 1013 dbSNP
rs897498508 1023 dbSNP
rs913438631 1045 dbSNP
rs1188883784 1047 dbSNP
rs1040090068 1048 dbSNP
rs1258724266 1054 dbSNP
rs1190525235 1061 dbSNP
rs1484874638 1062 dbSNP
rs990245676 1063 dbSNP
rs1280271503 1067 dbSNP
rs1480533249 1071 dbSNP
rs944457383 1075 dbSNP
rs1397897096 1076 dbSNP
rs57498938 1077 dbSNP
rs76064823 1084 dbSNP
rs1029128991 1094 dbSNP
rs995925484 1111 dbSNP
rs1282241874 1116 dbSNP
rs1332025637 1120 dbSNP
rs1356147502 1122 dbSNP
rs1434404378 1125 dbSNP
rs1274289009 1132 dbSNP
rs529688914 1136 dbSNP
rs1356352393 1139 dbSNP
rs1276502925 1145 dbSNP
rs1295281562 1145 dbSNP
rs529808008 1146 dbSNP
rs1219573860 1149 dbSNP
rs1275732324 1157 dbSNP
rs567456564 1160 dbSNP
rs1218772343 1168 dbSNP
rs1353277207 1172 dbSNP
rs192052530 1174 dbSNP
rs749872447 1192 dbSNP
rs1004835906 1197 dbSNP
rs1201219998 1204 dbSNP
rs1054732818 1210 dbSNP
rs527395075 1210 dbSNP
rs1346519157 1211 dbSNP
rs1156295057 1218 dbSNP
rs886321960 1223 dbSNP
rs934643429 1224 dbSNP
rs1403486272 1234 dbSNP
rs542952223 1234 dbSNP
rs1366313079 1239 dbSNP
rs1048927355 1242 dbSNP
rs971878468 1249 dbSNP
rs1474462117 1251 dbSNP
rs188786999 1253 dbSNP
rs916025310 1257 dbSNP
rs995055102 1260 dbSNP
rs1272242785 1268 dbSNP
rs780410356 1273 dbSNP
rs184702459 1276 dbSNP
rs1187688332 1281 dbSNP
rs1228295398 1302 dbSNP
rs1291214175 1303 dbSNP
rs1487130025 1310 dbSNP
rs898593943 1331 dbSNP
rs1359605626 1334 dbSNP
rs1240807622 1337 dbSNP
rs1260597552 1339 dbSNP
rs1487734321 1354 dbSNP
rs1056313239 1361 dbSNP
rs531386685 1367 dbSNP
rs1193658309 1369 dbSNP
rs1243679825 1382 dbSNP
rs1471668634 1387 dbSNP
rs1162654694 1389 dbSNP
rs1385765559 1394 dbSNP
rs951898761 1395 dbSNP
rs140540874 1398 dbSNP
rs746251543 1400 dbSNP
rs1275306542 1402 dbSNP
rs201723367 1412 dbSNP
rs1360160045 1415 dbSNP
rs1045702971 1419 dbSNP
rs1320501651 1421 dbSNP
rs1339149598 1425 dbSNP
rs1447748433 1429 dbSNP
rs781488210 1429 dbSNP
rs1385530355 1430 dbSNP
rs913459944 1431 dbSNP
rs1247573908 1434 dbSNP
rs1283199804 1440 dbSNP
rs1332463585 1444 dbSNP
rs543316237 1447 dbSNP
rs757528881 1464 dbSNP
rs957799746 1472 dbSNP
rs1186502600 1473 dbSNP
rs751753934 1479 dbSNP
rs574104907 1481 dbSNP
rs1019024635 1482 dbSNP
rs1433749797 1498 dbSNP
rs974935972 1507 dbSNP
rs965815068 1511 dbSNP
rs774465396 1512 dbSNP
rs1176681107 1514 dbSNP
rs1394554030 1530 dbSNP
rs777899749 1531 dbSNP
rs1018629673 1535 dbSNP
rs1400264755 1537 dbSNP
rs888852236 1538 dbSNP
rs1337755480 1540 dbSNP
rs1385646842 1541 dbSNP
rs1445277732 1542 dbSNP
rs1309131015 1546 dbSNP
rs1327552479 1548 dbSNP
rs1334725065 1553 dbSNP
rs1239118359 1555 dbSNP
rs1050198632 1574 dbSNP
rs758397214 1575 dbSNP
rs1368314741 1577 dbSNP
rs564128636 1587 dbSNP
rs983076818 1597 dbSNP
rs893323945 1613 dbSNP
rs1263585516 1615 dbSNP
rs80271201 1615 dbSNP
rs1196744996 1618 dbSNP
rs1027544003 1621 dbSNP
rs1237483350 1624 dbSNP
rs1418030879 1626 dbSNP
rs1419761297 1627 dbSNP
rs1183997705 1629 dbSNP
rs1188430678 1629 dbSNP
rs1477793657 1632 dbSNP
rs934902263 1643 dbSNP
rs577694568 1645 dbSNP
rs994753302 1650 dbSNP
rs924920792 1671 dbSNP
rs766229063 1673 dbSNP
rs557876227 1675 dbSNP
rs1046131327 1676 dbSNP
rs1254931930 1677 dbSNP
rs950103049 1677 dbSNP
rs1391464601 1680 dbSNP
rs192999625 1681 dbSNP
rs915971384 1684 dbSNP
rs749293598 1687 dbSNP
rs1283525934 1692 dbSNP
rs1325494775 1693 dbSNP
rs760617512 1695 dbSNP
rs991546417 1696 dbSNP
rs1480894976 1697 dbSNP
rs951848620 1703 dbSNP
rs1488269536 1711 dbSNP
rs1451077113 1726 dbSNP
rs3087804 1730 dbSNP
rs1431695562 1731 dbSNP
rs879821638 1740 dbSNP
rs1170325069 1743 dbSNP
rs556135582 1748 dbSNP
rs1464026985 1767 dbSNP
rs1270265022 1775 dbSNP
rs1225346183 1776 dbSNP
rs1002061768 1778 dbSNP
rs1403788317 1791 dbSNP
rs187980888 1796 dbSNP
rs962262661 1798 dbSNP
rs1308992578 1800 dbSNP
rs1018894364 1806 dbSNP
rs1294523435 1806 dbSNP
rs907265142 1807 dbSNP
rs1307837048 1808 dbSNP
rs536567379 1815 dbSNP
rs1340538731 1828 dbSNP
rs1229569412 1831 dbSNP
rs761597506 1833 dbSNP
rs1263604819 1834 dbSNP
rs1008964146 1835 dbSNP
rs567311302 1838 dbSNP
rs1028720403 1839 dbSNP
rs1045714305 1842 dbSNP
rs182643228 1843 dbSNP
rs534009103 1846 dbSNP
rs189773732 1856 dbSNP
rs1055137219 1857 dbSNP
rs936262145 1871 dbSNP
rs922127971 1876 dbSNP
rs1163363707 1885 dbSNP
rs1368342679 1891 dbSNP
rs1423457314 1900 dbSNP
rs1163626070 1903 dbSNP
rs1327319971 1905 dbSNP
rs1417534524 1906 dbSNP
rs1287891638 1909 dbSNP
rs1362478502 1916 dbSNP
rs146810953 1917 dbSNP
rs1310500856 1924 dbSNP
rs1381857486 1929 dbSNP
rs531169313 1935 dbSNP
rs879723749 1939 dbSNP
rs1298356588 1941 dbSNP
rs1215424286 1945 dbSNP
rs1351565653 1945 dbSNP
rs1463874155 1946 dbSNP
rs1054617338 1947 dbSNP
rs999059850 1953 dbSNP
rs1180416777 1957 dbSNP
rs903414768 1957 dbSNP
rs1455081043 1959 dbSNP
rs944440504 1961 dbSNP
rs1445716614 1963 dbSNP
rs1185942008 1973 dbSNP
rs562509201 1979 dbSNP
rs1191838617 1983 dbSNP
rs1417311808 1985 dbSNP
rs1157994621 1993 dbSNP
rs145075086 1994 dbSNP
rs1455154093 1999 dbSNP
rs1300820035 2001 dbSNP
rs950393211 2010 dbSNP
rs1027305941 2017 dbSNP
rs529607551 2025 dbSNP
rs1317076448 2026 dbSNP
rs1197720152 2030 dbSNP
rs55933526 2034 dbSNP
rs746536902 2035 dbSNP
rs1307984501 2037 dbSNP
rs1318918230 2045 dbSNP
rs1208495736 2046 dbSNP
rs1272210699 2052 dbSNP
rs1462022572 2053 dbSNP
rs1206194683 2056 dbSNP
rs1033940864 2057 dbSNP
rs7757 2063 dbSNP
rs907307666 2064 dbSNP
rs920713146 2064 dbSNP
rs1305449991 2072 dbSNP
rs879182900 2081 dbSNP
rs577856623 2090 dbSNP
rs1428425290 2092 dbSNP
rs1470115648 2105 dbSNP
rs1329955749 2106 dbSNP
rs1307323529 2112 dbSNP
rs1397944141 2123 dbSNP
rs1010256925 2127 dbSNP
rs1298772269 2139 dbSNP
rs891835810 2145 dbSNP
rs1217731758 2147 dbSNP
rs1282879320 2148 dbSNP
rs1371715358 2154 dbSNP
rs1324789332 2164 dbSNP
rs1054452727 2167 dbSNP
rs911777228 2177 dbSNP
rs987422083 2178 dbSNP
rs1045742 2189 dbSNP
rs35288772 2190 dbSNP
rs1203233104 2191 dbSNP
rs34069538 2192 dbSNP
rs397853663 2192 dbSNP
rs1481327433 2195 dbSNP
rs989177491 2196 dbSNP
rs900714005 2200 dbSNP
rs1480645391 2201 dbSNP
rs1178275454 2211 dbSNP
rs1417324666 2224 dbSNP
rs544695120 2225 dbSNP
rs1465624603 2227 dbSNP
rs1364428323 2229 dbSNP
rs1039629182 2240 dbSNP
rs1356419651 2250 dbSNP
rs1434382564 2256 dbSNP
rs1302792277 2258 dbSNP
rs187633761 2286 dbSNP
rs999404321 2294 dbSNP
rs1276642929 2300 dbSNP
rs183382667 2306 dbSNP
rs1024943180 2307 dbSNP
rs1181194757 2307 dbSNP
rs1308766886 2308 dbSNP
rs1014462427 2310 dbSNP
rs983224447 2310 dbSNP
rs1490397490 2311 dbSNP
rs1055715722 2313 dbSNP
rs929038946 2314 dbSNP
rs930674413 2315 dbSNP
rs1187093787 2319 dbSNP
rs920290573 2320 dbSNP
rs973060239 2321 dbSNP
rs114465574 2322 dbSNP
rs1366448726 2322 dbSNP
rs911739852 2322 dbSNP
rs940493067 2322 dbSNP
rs987747471 2322 dbSNP
rs1260796668 2323 dbSNP
rs1243168263 2324 dbSNP
rs1377574232 2324 dbSNP
rs926539601 2324 dbSNP
rs981979469 2328 dbSNP
rs1031137497 2329 dbSNP
rs1216157780 2329 dbSNP
rs537249351 2329 dbSNP
rs989125845 2329 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 53339.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000379403.2 | 3UTR | uuccccuggcaauaauaauggcacuucaauaga
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
51 hsa-miR-4471 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082398 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 4
MIRT295740 KIF3B kinesin family member 3B 2 2
MIRT453005 CCDC115 coiled-coil domain containing 115 2 16
MIRT456180 ZDHHC6 zinc finger DHHC-type containing 6 2 2
MIRT457455 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT464992 TUBB2A tubulin beta 2A class IIa 2 10
MIRT467615 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468602 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT470070 PTGES2 prostaglandin E synthase 2 2 2
MIRT470562 POU2F1 POU class 2 homeobox 1 2 2
MIRT472274 NFIB nuclear factor I B 2 2
MIRT473471 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT477892 DVL3 dishevelled segment polarity protein 3 2 4
MIRT486345 TACC2 transforming acidic coiled-coil containing protein 2 2 6
MIRT487190 NFASC neurofascin 2 4
MIRT488690 NAT9 N-acetyltransferase 9 (putative) 2 2
MIRT492106 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT495216 DSCR3 DSCR3 arrestin fold containing 2 2
MIRT495666 TUBAL3 tubulin alpha like 3 2 2
MIRT501833 NCOA2 nuclear receptor coactivator 2 2 2
MIRT507147 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT508522 GDI1 GDP dissociation inhibitor 1 2 2
MIRT513839 KCTD15 potassium channel tetramerization domain containing 15 2 4
MIRT513883 GTF2IRD2 GTF2I repeat domain containing 2 2 4
MIRT527336 COL18A1 collagen type XVIII alpha 1 chain 2 2
MIRT537390 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT538879 BTBD1 BTB domain containing 1 2 2
MIRT539044 ATXN1L ataxin 1 like 2 4
MIRT554387 SERTAD3 SERTA domain containing 3 2 2
MIRT554936 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT567517 FOXC1 forkhead box C1 2 2
MIRT573598 CERS1 ceramide synthase 1 2 2
MIRT642417 CILP2 cartilage intermediate layer protein 2 2 2
MIRT643296 PHKG1 phosphorylase kinase catalytic subunit gamma 1 2 2
MIRT652883 SYVN1 synoviolin 1 2 2
MIRT657928 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT660302 BHLHE40 basic helix-loop-helix family member e40 2 2
MIRT664717 SLC7A6OS solute carrier family 7 member 6 opposite strand 2 2
MIRT698889 SPTBN2 spectrin beta, non-erythrocytic 2 2 2
MIRT702007 MIDN midnolin 2 2
MIRT706808 APOL4 apolipoprotein L4 2 2
MIRT708330 DERL2 derlin 2 2 2
MIRT709885 ERCC6L ERCC excision repair 6 like, spindle assembly checkpoint helicase 2 2
MIRT711887 INSIG2 insulin induced gene 2 2 2
MIRT711956 CYP27B1 cytochrome P450 family 27 subfamily B member 1 2 2
MIRT715081 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT716218 TRIM17 tripartite motif containing 17 2 2
MIRT718124 CHST4 carbohydrate sulfotransferase 4 2 2
MIRT718725 VWA9 integrator complex subunit 14 2 2
MIRT719450 APBA1 amyloid beta precursor protein binding family A member 1 2 2
MIRT725666 ABI2 abl interactor 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4471 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4471 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-4471 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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