>BRI3BP|NM_080626|3'UTR
   1 AGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCC
  81 CAAACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGA
 161 CACATTCCCAGAAGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTA
 241 AACAAAGGATATAACCATATTTAGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGC
 321 ATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCAAGTT

ID	Duplex structure	Position	Score	MFE
1	miRNA 3' ggacGAGGUUU-UUAGGuaa 5' | ||||| ||||: Target 5' caaaCCCCAAACAATCTtaa 3'	74 - 93	103.00	-6.22
2	miRNA 3' ggacgaGGUU--UUUAGGUaa 5' ||:: :::|||| Target 5' agccggCCGGGCGGGTCCAca 3'	6 - 26	91.00	-10.00
3	miRNA 3' ggacgaGGUUUUUAGGUAa 5' | :|||: :||| Target 5' gaagagCGGAAAGATCATt 3'	171 - 189	89.00	-6.10

Mutant ID	Mutant Position	Mutant Source
COSN30146883	10	COSMIC
COSN30451063	19	COSMIC
COSN31487617	19	COSMIC
COSN28852757	39	COSMIC
COSN30162357	44	COSMIC
COSN22817414	886	COSMIC
COSN27260080	902	COSMIC
COSN7314404	973	COSMIC
COSN7314405	986	COSMIC
COSN1560991	1026	COSMIC
COSN30715208	1092	COSMIC
COSN32140020	1312	COSMIC
COSN25112619	1341	COSMIC
COSN27772880	1433	COSMIC
COSN14824322	1454	COSMIC
COSN17670089	1712	COSMIC
COSN17453961	2489	COSMIC
COSN1560992	2518	COSMIC
COSN27925600	2669	COSMIC
COSN5933476	2815	COSMIC
COSN19105412	3113	COSMIC
COSN30683222	3174	COSMIC
COSN30600907	3333	COSMIC
COSN29968063	3350	COSMIC
COSN19071632	3394	COSMIC
COSN30558239	3415	COSMIC
COSN30611752	3435	COSMIC
COSN28490257	3780	COSMIC
COSN15703819	3861	COSMIC
COSN7314406	4054	COSMIC
COSN26423004	4314	COSMIC
COSN5933477	4375	COSMIC
COSN5933478	4378	COSMIC
COSN27547259	4470	COSMIC
COSN21481820	4637	COSMIC
COSN28525171	4825	COSMIC
COSN1560993	5760	COSMIC

Mutant ID	Mutant Position	Mutant Source
rs1372566329	3	dbSNP
rs1413180908	4	dbSNP
rs752295404	5	dbSNP
rs1380020708	6	dbSNP
rs1007717212	8	dbSNP
rs779045302	10	dbSNP
rs757845729	11	dbSNP
rs1414928738	13	dbSNP
rs1227314201	14	dbSNP
rs1275108095	17	dbSNP
rs190444285	18	dbSNP
rs1208322097	19	dbSNP
rs1416362289	24	dbSNP
rs1255096628	25	dbSNP
rs181788991	26	dbSNP
rs1016367860	27	dbSNP
rs963458400	32	dbSNP
rs757222511	36	dbSNP
rs1449397012	38	dbSNP
rs780825307	39	dbSNP
rs745623091	46	dbSNP
rs1343446553	47	dbSNP
rs769503836	48	dbSNP
rs1218967541	54	dbSNP
rs986766732	60	dbSNP
rs1283994041	63	dbSNP
rs1416286767	64	dbSNP
rs543318386	65	dbSNP
rs561392594	72	dbSNP
rs966579958	74	dbSNP
rs572826997	88	dbSNP
rs1482181518	89	dbSNP
rs992806405	92	dbSNP
rs1213123212	96	dbSNP
rs1468011441	99	dbSNP
rs1408348540	101	dbSNP
rs1235010296	109	dbSNP
rs977430560	110	dbSNP
rs915846514	113	dbSNP
rs1294578244	120	dbSNP
rs1212502068	122	dbSNP
rs1420488850	123	dbSNP
rs1055472	129	dbSNP
rs936088744	132	dbSNP
rs150800149	134	dbSNP
rs75976243	139	dbSNP
rs1458802151	141	dbSNP
rs1354390783	143	dbSNP
rs1168764836	148	dbSNP
rs1430572062	149	dbSNP
rs948893568	154	dbSNP
rs1045858345	155	dbSNP
rs550650510	163	dbSNP
rs73419937	171	dbSNP
rs900881051	173	dbSNP
rs933659978	178	dbSNP
rs1488758438	184	dbSNP
rs1250597925	185	dbSNP
rs1374440676	189	dbSNP
rs529816108	194	dbSNP
rs1308994251	195	dbSNP
rs548486683	203	dbSNP
rs889389010	204	dbSNP
rs1233031491	205	dbSNP
rs898145987	206	dbSNP
rs566637366	207	dbSNP
rs1373223021	208	dbSNP
rs1296852818	223	dbSNP
rs1016441562	224	dbSNP
rs899358575	226	dbSNP
rs993584989	226	dbSNP
rs534736131	227	dbSNP
rs546584650	228	dbSNP
rs571259108	231	dbSNP
rs1433739519	244	dbSNP
rs1440625752	244	dbSNP
rs1175358210	246	dbSNP
rs1019411635	248	dbSNP
rs966632007	262	dbSNP
rs781772728	263	dbSNP
rs1209789377	275	dbSNP
rs538756221	277	dbSNP
rs1022949481	279	dbSNP
rs1281909127	281	dbSNP
rs747626261	284	dbSNP
rs1458870589	288	dbSNP
rs978691133	293	dbSNP
rs1393589535	297	dbSNP
rs1176425402	298	dbSNP
rs1312649776	310	dbSNP
rs1351491861	310	dbSNP
rs746186891	317	dbSNP
rs556999171	320	dbSNP
rs1237134793	327	dbSNP
rs1454369984	330	dbSNP
rs925839789	334	dbSNP
rs139807689	339	dbSNP
rs988628640	347	dbSNP
rs922380024	356	dbSNP
rs536420304	358	dbSNP
rs957345625	364	dbSNP
rs555281094	367	dbSNP
rs1186937440	369	dbSNP
rs1484510194	379	dbSNP
rs1049888458	383	dbSNP
rs1449399499	383	dbSNP
rs1200630210	393	dbSNP
rs1329619900	395	dbSNP
rs1258365612	396	dbSNP
rs1376400579	400	dbSNP
rs1293103168	417	dbSNP
rs1231875800	421	dbSNP
rs1357702372	431	dbSNP
rs915983568	435	dbSNP
rs910901521	437	dbSNP
rs948797480	440	dbSNP
rs573451397	442	dbSNP
rs1382962661	450	dbSNP
rs1290691700	451	dbSNP
rs67037258	452	dbSNP
rs1412587608	453	dbSNP
rs1342888490	461	dbSNP
rs1164083564	467	dbSNP
rs928782803	470	dbSNP
rs940298160	476	dbSNP
rs1369923359	480	dbSNP
rs1187823130	484	dbSNP
rs145293906	489	dbSNP
rs1259127998	500	dbSNP
rs993658572	503	dbSNP
rs1213883084	505	dbSNP
rs1273130534	510	dbSNP
rs375717291	513	dbSNP
rs1231934046	518	dbSNP
rs1358909773	524	dbSNP
rs1285147900	525	dbSNP
rs185088540	527	dbSNP
rs1319762104	535	dbSNP
rs895910224	540	dbSNP
rs1014329125	542	dbSNP
rs1435950034	547	dbSNP
rs930976177	549	dbSNP
rs1393771644	555	dbSNP
rs1325156872	560	dbSNP
rs1049366813	562	dbSNP
rs1392699045	568	dbSNP
rs1196500300	574	dbSNP
rs1474900242	575	dbSNP
rs889544194	582	dbSNP
rs1007950800	583	dbSNP
rs1200483014	585	dbSNP
rs1251758424	591	dbSNP
rs1019886289	593	dbSNP
rs1212436334	603	dbSNP
rs1453818451	609	dbSNP
rs1291097057	610	dbSNP
rs1195562678	611	dbSNP
rs1337813009	627	dbSNP
rs902329373	627	dbSNP
rs1277069265	633	dbSNP
rs1229343981	636	dbSNP
rs999472235	640	dbSNP
rs1032253571	642	dbSNP
rs1370346856	644	dbSNP
rs1477386770	646	dbSNP
rs1434293571	660	dbSNP
rs1191148813	666	dbSNP
rs957399329	670	dbSNP
rs970067152	672	dbSNP
rs1409176504	678	dbSNP
rs1393991097	683	dbSNP
rs1170097917	686	dbSNP
rs990562861	688	dbSNP
rs1424943856	699	dbSNP
rs1394009525	701	dbSNP
rs1191178071	712	dbSNP
rs147252198	741	dbSNP
rs73231614	743	dbSNP
rs1032937054	747	dbSNP
rs1399914558	753	dbSNP
rs1462175719	761	dbSNP
rs1325697472	769	dbSNP
rs1329446675	770	dbSNP
rs771601274	785	dbSNP
rs1270744173	788	dbSNP
rs989091014	790	dbSNP
rs1221044962	798	dbSNP
rs1345747154	804	dbSNP
rs1275381317	807	dbSNP
rs1441306950	826	dbSNP
rs1486181522	827	dbSNP
rs140681143	828	dbSNP
rs970564957	836	dbSNP
rs1374440965	840	dbSNP
rs1173473026	854	dbSNP
rs1335166887	855	dbSNP
rs1211302020	861	dbSNP
rs1287247501	864	dbSNP
rs981530654	867	dbSNP
rs112759273	886	dbSNP
rs1485491697	886	dbSNP
rs1255697246	887	dbSNP
rs1264617291	888	dbSNP
rs11313217	889	dbSNP
rs1228808384	889	dbSNP
rs1443079467	889	dbSNP
rs398044850	889	dbSNP
rs868619381	889	dbSNP
rs201766514	890	dbSNP
rs1300733215	902	dbSNP
rs368670998	902	dbSNP
rs368406630	903	dbSNP
rs1473307076	907	dbSNP
rs1435633908	908	dbSNP
rs1388818650	912	dbSNP
rs149804945	913	dbSNP
rs1414796212	914	dbSNP
rs560442914	916	dbSNP
rs1298874911	921	dbSNP
rs955354787	924	dbSNP
rs985245151	934	dbSNP
rs1473239226	935	dbSNP
rs1241642428	956	dbSNP
rs1362479557	957	dbSNP
rs910931573	963	dbSNP
rs1398080462	971	dbSNP
rs1277444366	972	dbSNP
rs66836373	979	dbSNP
rs1333899268	984	dbSNP
rs1229734095	993	dbSNP
rs1379417325	1003	dbSNP
rs1246689826	1004	dbSNP
rs145738187	1013	dbSNP
rs1355205239	1023	dbSNP
rs1223911961	1033	dbSNP
rs920179551	1041	dbSNP
rs931549252	1052	dbSNP
rs920883820	1053	dbSNP
rs1321811256	1060	dbSNP
rs1215122829	1061	dbSNP
rs929540469	1062	dbSNP
rs1167315763	1071	dbSNP
rs1424652529	1075	dbSNP
rs1419110647	1080	dbSNP
rs1186854739	1082	dbSNP
rs1048391904	1089	dbSNP
rs1189217677	1090	dbSNP
rs1467967579	1097	dbSNP
rs1263508782	1098	dbSNP
rs1049876706	1100	dbSNP
rs910867335	1112	dbSNP
rs760261591	1117	dbSNP
rs1322061043	1118	dbSNP
rs1271867279	1121	dbSNP
rs896000523	1122	dbSNP
rs10083110	1130	dbSNP
rs1440881066	1131	dbSNP
rs187987910	1134	dbSNP
rs1044491437	1135	dbSNP
rs538617852	1139	dbSNP
rs201022683	1140	dbSNP
rs753806631	1151	dbSNP
rs1458754025	1152	dbSNP
rs1159410075	1155	dbSNP
rs753783476	1159	dbSNP
rs905913579	1169	dbSNP
rs551079178	1188	dbSNP
rs369119908	1192	dbSNP
rs1173063864	1201	dbSNP
rs569239346	1207	dbSNP
rs536894688	1208	dbSNP
rs67625612	1209	dbSNP
rs1265223224	1212	dbSNP
rs1192803321	1216	dbSNP
rs1488686454	1222	dbSNP
rs1033009799	1225	dbSNP
rs567025858	1226	dbSNP
rs558448016	1227	dbSNP
rs118116501	1231	dbSNP
rs7304738	1232	dbSNP
rs1023410640	1245	dbSNP
rs1309881230	1247	dbSNP
rs1331935474	1248	dbSNP
rs576936783	1249	dbSNP
rs1387788858	1251	dbSNP
rs1339591675	1258	dbSNP
rs1003401458	1261	dbSNP
rs1239321480	1262	dbSNP
rs1035732470	1263	dbSNP
rs544007315	1265	dbSNP
rs1371366018	1270	dbSNP
rs1350890037	1272	dbSNP
rs777876088	1275	dbSNP
rs972884388	1276	dbSNP
rs962431507	1279	dbSNP
rs920066882	1288	dbSNP
rs953096625	1289	dbSNP
rs1252113260	1297	dbSNP
rs1483889235	1297	dbSNP
rs973730948	1303	dbSNP
rs751554550	1308	dbSNP
rs1285975000	1311	dbSNP
rs1481993609	1313	dbSNP
rs544206134	1337	dbSNP
rs918237511	1339	dbSNP
rs929603657	1345	dbSNP
rs1346319780	1349	dbSNP
rs1286889302	1350	dbSNP
rs1230658146	1352	dbSNP
rs562638580	1353	dbSNP
rs1254519807	1369	dbSNP
rs372044430	1376	dbSNP
rs1466525253	1380	dbSNP
rs1387851808	1383	dbSNP
rs1156794881	1384	dbSNP
rs1473456563	1385	dbSNP
rs574445156	1395	dbSNP
rs1044576124	1396	dbSNP
rs550836627	1397	dbSNP
rs1257723916	1405	dbSNP
rs148983924	1407	dbSNP
rs1464018372	1408	dbSNP
rs923690362	1412	dbSNP
rs1266809767	1415	dbSNP
rs1378192109	1416	dbSNP
rs1467535651	1417	dbSNP
rs1170673906	1421	dbSNP
rs1242945721	1436	dbSNP
rs1342454689	1440	dbSNP
rs935038013	1441	dbSNP
rs936054070	1446	dbSNP
rs527447586	1451	dbSNP
rs1381740556	1455	dbSNP
rs1386465427	1458	dbSNP
rs1053636055	1463	dbSNP
rs563583103	1464	dbSNP
rs1389183948	1466	dbSNP
rs893621742	1471	dbSNP
rs1162415033	1472	dbSNP
rs569331330	1479	dbSNP
rs1374156903	1480	dbSNP
rs1187754346	1483	dbSNP
rs1044978931	1487	dbSNP
rs1245597216	1488	dbSNP
rs1301340250	1498	dbSNP
rs1465724987	1512	dbSNP
rs1289667253	1517	dbSNP
rs1208462521	1519	dbSNP
rs1358846696	1520	dbSNP
rs1227860081	1522	dbSNP
rs1266273182	1522	dbSNP
rs1365804478	1522	dbSNP
rs1437254104	1522	dbSNP
rs34513244	1522	dbSNP
rs397712123	1522	dbSNP
rs891819915	1522	dbSNP
rs1384888435	1523	dbSNP
rs1392549063	1524	dbSNP
rs1163488973	1529	dbSNP
rs1332259927	1535	dbSNP
rs1428687795	1536	dbSNP
rs1169900959	1537	dbSNP
rs1387832969	1537	dbSNP
rs1236114832	1538	dbSNP
rs1010614025	1544	dbSNP
rs1246660119	1550	dbSNP
rs1197301628	1553	dbSNP
rs1453689159	1561	dbSNP
rs1268487594	1567	dbSNP
rs11058000	1568	dbSNP
rs1340275084	1571	dbSNP
rs1276911811	1575	dbSNP
rs1229270640	1576	dbSNP
rs1002830652	1577	dbSNP
rs1274200478	1587	dbSNP
rs1035619854	1590	dbSNP
rs961456668	1604	dbSNP
rs564014816	1613	dbSNP
rs891026542	1614	dbSNP
rs1027135610	1624	dbSNP
rs746382799	1625	dbSNP
rs1006762076	1627	dbSNP
rs986150962	1637	dbSNP
rs911476505	1640	dbSNP
rs770283346	1641	dbSNP
rs1479281160	1644	dbSNP
rs532402988	1645	dbSNP
rs973807823	1648	dbSNP
rs1482255885	1649	dbSNP
rs1254272569	1655	dbSNP
rs1206072231	1664	dbSNP
rs1025325921	1665	dbSNP
rs1434939929	1669	dbSNP
rs550693802	1670	dbSNP
rs1312202882	1676	dbSNP
rs1217451533	1682	dbSNP
rs1196694919	1686	dbSNP
rs1283799626	1687	dbSNP
rs531560368	1691	dbSNP
rs1348332636	1692	dbSNP
rs1289839861	1705	dbSNP
rs1442474592	1710	dbSNP
rs1358128271	1717	dbSNP
rs935091682	1720	dbSNP
rs1416693517	1731	dbSNP
rs989215400	1738	dbSNP
rs530142134	1740	dbSNP
rs780626736	1745	dbSNP
rs548625359	1767	dbSNP
rs1403581898	1772	dbSNP
rs992202699	1775	dbSNP
rs1397741467	1789	dbSNP
rs1464787561	1790	dbSNP
rs1414566934	1806	dbSNP
rs1045260093	1809	dbSNP
rs906456861	1812	dbSNP
rs747817811	1820	dbSNP
rs1057080201	1823	dbSNP
rs950347418	1833	dbSNP
rs1369137609	1841	dbSNP
rs897146382	1843	dbSNP
rs1443023101	1849	dbSNP
rs994243802	1851	dbSNP
rs1207958252	1856	dbSNP
rs1326892025	1856	dbSNP
rs1289968105	1867	dbSNP
rs980290788	1870	dbSNP
rs567086905	1871	dbSNP
rs1282025838	1874	dbSNP
rs1449615122	1886	dbSNP
rs1345431680	1889	dbSNP
rs1320485475	1895	dbSNP
rs534364215	1895	dbSNP
rs936129557	1896	dbSNP
rs1007063242	1897	dbSNP
rs1160245888	1900	dbSNP
rs559320671	1902	dbSNP
rs1411921985	1903	dbSNP
rs1183753758	1904	dbSNP
rs1054547064	1909	dbSNP
rs1280505542	1912	dbSNP
rs558098259	1916	dbSNP
rs1247484701	1917	dbSNP
rs1187912994	1925	dbSNP
rs542340365	1926	dbSNP
rs1051529781	1928	dbSNP
rs1320838940	1934	dbSNP
rs965673766	1940	dbSNP
rs891066353	1950	dbSNP
rs1266210192	1960	dbSNP
rs537892879	1961	dbSNP
rs12820208	1965	dbSNP
rs111457986	1967	dbSNP
rs1208104420	1970	dbSNP
rs956349384	1972	dbSNP
rs1025358395	1973	dbSNP
rs1195677304	1979	dbSNP
rs1421209837	1983	dbSNP
rs1425521094	1988	dbSNP
rs1477346984	1992	dbSNP
rs989267719	1997	dbSNP
rs914999293	1999	dbSNP
rs947759536	2003	dbSNP
rs1165108806	2007	dbSNP
rs1013292641	2010	dbSNP
rs1351230401	2012	dbSNP
rs1455995180	2021	dbSNP
rs376942689	2022	dbSNP
rs772936841	2028	dbSNP
rs980367317	2030	dbSNP
rs927489042	2031	dbSNP
rs1401149153	2036	dbSNP
rs1300544082	2038	dbSNP
rs1223395326	2039	dbSNP
rs534107102	2042	dbSNP
rs1338929774	2046	dbSNP
rs948452885	2049	dbSNP
rs1313751409	2050	dbSNP
rs1323725746	2053	dbSNP
rs957533600	2054	dbSNP
rs1242770242	2058	dbSNP
rs990308871	2059	dbSNP
rs1296922174	2068	dbSNP
rs1036224201	2069	dbSNP
rs1366003147	2070	dbSNP
rs897196698	2072	dbSNP
rs1295627970	2074	dbSNP
rs913352688	2075	dbSNP
rs1370223018	2079	dbSNP
rs929978852	2084	dbSNP
rs868232969	2086	dbSNP
rs1306357456	2095	dbSNP
rs1431720554	2096	dbSNP
rs866169505	2098	dbSNP
rs1048837847	2100	dbSNP
rs888548117	2102	dbSNP
rs1432517365	2103	dbSNP
rs1218739904	2114	dbSNP
rs1201281400	2120	dbSNP
rs1007361141	2123	dbSNP
rs1260912839	2125	dbSNP
rs1051129866	2128	dbSNP
rs542099534	2133	dbSNP
rs1251368792	2134	dbSNP
rs1210092471	2142	dbSNP
rs1310925139	2147	dbSNP
rs1303998414	2151	dbSNP
rs75394392	2155	dbSNP
rs1415586296	2156	dbSNP
rs1286689191	2157	dbSNP
rs571935106	2172	dbSNP
rs1163553466	2173	dbSNP
rs1397380305	2182	dbSNP
rs1380412803	2183	dbSNP
rs1420931929	2192	dbSNP
rs180798686	2195	dbSNP
rs1031255549	2197	dbSNP
rs956902468	2202	dbSNP
rs989168277	2203	dbSNP
rs1359152681	2206	dbSNP
rs1430545472	2210	dbSNP
rs1464192657	2219	dbSNP
rs1480640780	2219	dbSNP
rs1303774552	2220	dbSNP
rs1381718728	2221	dbSNP
rs1410943251	2225	dbSNP
rs1179641752	2228	dbSNP
rs868322240	2235	dbSNP
rs969184922	2236	dbSNP
rs1180804626	2240	dbSNP
rs1314578679	2240	dbSNP
rs980913178	2240	dbSNP
rs1265559337	2246	dbSNP
rs79988895	2248	dbSNP
rs79659029	2250	dbSNP
rs1204793318	2262	dbSNP
rs1328988912	2267	dbSNP
rs942682343	2267	dbSNP
rs1230522881	2271	dbSNP
rs1336548019	2277	dbSNP
rs77217266	2278	dbSNP
rs77353332	2279	dbSNP
rs927848528	2281	dbSNP
rs1394374848	2292	dbSNP
rs564082319	2297	dbSNP
rs1381341216	2299	dbSNP
rs960520976	2301	dbSNP
rs185646048	2305	dbSNP
rs919180287	2311	dbSNP
rs930530190	2318	dbSNP
rs1283884684	2319	dbSNP
rs1316259735	2321	dbSNP
rs1156646405	2324	dbSNP
rs1210659117	2327	dbSNP
rs1364040355	2328	dbSNP
rs1238993255	2329	dbSNP
rs1186331958	2335	dbSNP
rs1421550792	2338	dbSNP
rs1244441292	2344	dbSNP
rs1048405152	2345	dbSNP
rs1464827564	2351	dbSNP
rs867136148	2352	dbSNP
rs909854392	2359	dbSNP
rs942826370	2360	dbSNP
rs1351792612	2361	dbSNP
rs543656909	2363	dbSNP
rs1265086042	2369	dbSNP
rs7309091	2371	dbSNP
rs1361749527	2386	dbSNP
rs998356870	2391	dbSNP
rs1024698981	2392	dbSNP
rs1364410829	2395	dbSNP
rs1052570312	2403	dbSNP
rs1400647794	2404	dbSNP
rs969461373	2408	dbSNP
rs1162354386	2409	dbSNP
rs1001834842	2411	dbSNP
rs1034632303	2412	dbSNP
rs957603988	2415	dbSNP
rs1448310889	2416	dbSNP
rs1388888442	2419	dbSNP
rs990339993	2433	dbSNP
rs913376905	2434	dbSNP
rs868342764	2435	dbSNP
rs1490892867	2441	dbSNP
rs191328159	2448	dbSNP
rs1021985928	2449	dbSNP
rs912609953	2452	dbSNP
rs1336369811	2456	dbSNP
rs969448130	2457	dbSNP
rs1001994064	2460	dbSNP
rs1449172222	2464	dbSNP
rs1367090010	2467	dbSNP
rs1307195531	2474	dbSNP
rs1428560014	2477	dbSNP
rs1034729591	2479	dbSNP
rs960408799	2480	dbSNP
rs1280591020	2483	dbSNP
rs971882453	2485	dbSNP
rs939611572	2489	dbSNP
rs919065492	2493	dbSNP
rs1052611926	2498	dbSNP
rs866918418	2500	dbSNP
rs985098466	2501	dbSNP
rs931214592	2502	dbSNP
rs551061229	2503	dbSNP
rs566950151	2504	dbSNP
rs749814621	2505	dbSNP
rs1274140393	2509	dbSNP
rs1221491298	2510	dbSNP
rs922689608	2512	dbSNP
rs1347101653	2517	dbSNP
rs934033822	2521	dbSNP
rs1231815318	2523	dbSNP
rs527922833	2524	dbSNP
rs1143424	2532	dbSNP
rs1192305645	2533	dbSNP
rs892621266	2537	dbSNP
rs1427835074	2538	dbSNP
rs1011186791	2547	dbSNP
rs1471163114	2547	dbSNP
rs1044361174	2548	dbSNP
rs115092463	2549	dbSNP
rs769348771	2550	dbSNP
rs1182665842	2551	dbSNP
rs1467384576	2559	dbSNP
rs1277852745	2560	dbSNP
rs1201622280	2563	dbSNP
rs1329514233	2566	dbSNP
rs571009854	2568	dbSNP
rs1227441835	2579	dbSNP
rs1034616572	2580	dbSNP
rs538164483	2585	dbSNP
rs1370762533	2586	dbSNP
rs1031992542	2587	dbSNP
rs993185755	2599	dbSNP
rs1280875612	2609	dbSNP
rs7137850	2623	dbSNP
rs1276585886	2629	dbSNP
rs951962593	2644	dbSNP
rs530676854	2647	dbSNP
rs1365397815	2648	dbSNP
rs1471235324	2650	dbSNP
rs762280787	2663	dbSNP
rs1278623842	2669	dbSNP
rs141457185	2675	dbSNP
rs1319648364	2676	dbSNP
rs1159309979	2680	dbSNP
rs1472513910	2681	dbSNP
rs183571698	2690	dbSNP
rs186861598	2698	dbSNP
rs975423381	2704	dbSNP
rs1271788426	2715	dbSNP
rs1243633575	2717	dbSNP
rs922572455	2723	dbSNP
rs776542068	2724	dbSNP
rs967953811	2747	dbSNP
rs1223987686	2749	dbSNP
rs1285919366	2749	dbSNP
rs1451722146	2752	dbSNP
rs986954559	2756	dbSNP
rs1312253752	2758	dbSNP
rs1020151353	2763	dbSNP
rs964095059	2767	dbSNP
rs934086460	2768	dbSNP
rs1347254120	2770	dbSNP
rs988212348	2774	dbSNP
rs931286930	2778	dbSNP
rs914107286	2782	dbSNP
rs544390051	2783	dbSNP
rs879397865	2793	dbSNP
rs1445259327	2795	dbSNP
rs1385799180	2797	dbSNP
rs553482830	2801	dbSNP
rs1199244936	2809	dbSNP
rs946872384	2811	dbSNP
rs983124157	2813	dbSNP
rs1243620080	2815	dbSNP
rs908420067	2816	dbSNP
rs1043861715	2817	dbSNP
rs905453652	2821	dbSNP
rs759527246	2831	dbSNP
rs1359466229	2833	dbSNP
rs1297522889	2844	dbSNP
rs1213322975	2845	dbSNP
rs1056077021	2847	dbSNP
rs896139724	2850	dbSNP
rs1436156200	2867	dbSNP
rs1406090004	2871	dbSNP
rs1305124301	2873	dbSNP
rs1425385273	2878	dbSNP
rs1325593610	2879	dbSNP
rs1348140088	2886	dbSNP
rs1370023781	2888	dbSNP
rs993239766	2891	dbSNP
rs1404258835	2898	dbSNP
rs866926343	2899	dbSNP
rs1421441093	2902	dbSNP
rs1186921594	2909	dbSNP
rs1479961227	2913	dbSNP
rs1266349864	2917	dbSNP
rs904964471	2918	dbSNP
rs937730045	2919	dbSNP
rs571796552	2920	dbSNP
rs1203078019	2931	dbSNP
rs1309811756	2937	dbSNP
rs1296856972	2939	dbSNP
rs764992736	2943	dbSNP
rs1006473948	2944	dbSNP
rs1269302234	2947	dbSNP
rs66754239	2950	dbSNP
rs762839303	2954	dbSNP
rs145154624	2955	dbSNP
rs1029698770	2958	dbSNP
rs955351972	2969	dbSNP
rs1463556981	2974	dbSNP
rs1356231283	2976	dbSNP
rs576147861	2984	dbSNP
rs1426941662	2987	dbSNP
rs913978679	2993	dbSNP
rs946790122	3000	dbSNP
rs1249329781	3010	dbSNP
rs567496656	3033	dbSNP
rs964127959	3035	dbSNP
rs1489499303	3036	dbSNP
rs975484572	3039	dbSNP
rs1027004812	3045	dbSNP
rs543370202	3047	dbSNP
rs561989221	3054	dbSNP
rs1328788069	3061	dbSNP
rs1241802234	3062	dbSNP
rs1305075643	3065	dbSNP
rs1374067448	3068	dbSNP
rs202113349	3068	dbSNP
rs952720745	3068	dbSNP
rs1451812909	3070	dbSNP
rs1403705101	3074	dbSNP
rs938292502	3080	dbSNP
rs1056631676	3081	dbSNP
rs1473256510	3084	dbSNP
rs908492215	3092	dbSNP
rs866216247	3094	dbSNP
rs1420424116	3096	dbSNP
rs928974152	3098	dbSNP
rs191981385	3105	dbSNP
rs1183565494	3106	dbSNP
rs887535953	3115	dbSNP
rs1245467483	3116	dbSNP
rs1204736494	3118	dbSNP
rs1005946482	3125	dbSNP
rs926455507	3126	dbSNP
rs1017878181	3130	dbSNP
rs937803399	3134	dbSNP
rs1053534610	3137	dbSNP
rs1243814361	3138	dbSNP
rs1380517082	3139	dbSNP
rs1159228447	3141	dbSNP
rs1453103929	3142	dbSNP
rs542190981	3152	dbSNP
rs1383964484	3154	dbSNP
rs1286814589	3158	dbSNP
rs900319844	3161	dbSNP
rs997469549	3174	dbSNP
rs560614982	3177	dbSNP
rs1317395592	3183	dbSNP
rs1442189750	3190	dbSNP
rs1387648813	3191	dbSNP
rs1340782672	3198	dbSNP
rs945071378	3200	dbSNP
rs11549743	3204	dbSNP
rs1358168798	3210	dbSNP
rs1207173221	3215	dbSNP
rs1240206771	3225	dbSNP
rs137891643	3231	dbSNP
rs1220363861	3242	dbSNP
rs1361592883	3247	dbSNP
rs1317154812	3255	dbSNP
rs1246605110	3257	dbSNP
rs11549742	3263	dbSNP
rs531903862	3295	dbSNP
rs550233174	3299	dbSNP
rs750957006	3304	dbSNP
rs1203842830	3312	dbSNP
rs1293136549	3313	dbSNP
rs1383665099	3326	dbSNP
rs550773006	3326	dbSNP
rs1261476606	3327	dbSNP
rs1302080418	3334	dbSNP
rs1422221065	3340	dbSNP
rs926815175	3343	dbSNP
rs1041255438	3356	dbSNP
rs959527595	3360	dbSNP
rs996931998	3362	dbSNP
rs992244801	3367	dbSNP
rs1027058949	3373	dbSNP
rs1444125037	3380	dbSNP
rs996882711	3381	dbSNP
rs1179324673	3383	dbSNP
rs918175115	3385	dbSNP
rs1451555132	3387	dbSNP
rs183255805	3388	dbSNP
rs1030066447	3391	dbSNP
rs756736879	3392	dbSNP
rs1004643801	3395	dbSNP
rs1415941326	3399	dbSNP
rs1015580386	3400	dbSNP
rs929530716	3401	dbSNP
rs1381581841	3404	dbSNP
rs1446955319	3407	dbSNP
rs982043648	3415	dbSNP
rs926486206	3416	dbSNP
rs1310828855	3418	dbSNP
rs1047869053	3422	dbSNP
rs1303202339	3433	dbSNP
rs959199980	3438	dbSNP
rs989306766	3439	dbSNP
rs1237563958	3441	dbSNP
rs1170094297	3442	dbSNP
rs908858868	3451	dbSNP
rs1260593976	3455	dbSNP
rs1429026282	3461	dbSNP
rs915033759	3463	dbSNP
rs1202510412	3466	dbSNP
rs941803862	3468	dbSNP
rs1269810732	3470	dbSNP
rs1038776178	3474	dbSNP
rs11549744	3484	dbSNP
rs1436083714	3485	dbSNP
rs1461050470	3490	dbSNP
rs1042476274	3492	dbSNP
rs1197468556	3493	dbSNP
rs1199436227	3503	dbSNP
rs1262242040	3505	dbSNP
rs546988737	3509	dbSNP
rs535018581	3510	dbSNP
rs765285816	3511	dbSNP
rs749563877	3528	dbSNP
rs755380805	3532	dbSNP
rs891732545	3533	dbSNP
rs561970410	3542	dbSNP
rs140770124	3543	dbSNP
rs1378103951	3544	dbSNP
rs1478926569	3557	dbSNP
rs1021399289	3578	dbSNP
rs1174756977	3588	dbSNP
rs557400114	3600	dbSNP
rs1471138018	3601	dbSNP
rs1173969547	3611	dbSNP
rs900085050	3614	dbSNP
rs968066055	3635	dbSNP
rs1048523893	3646	dbSNP
rs1001395953	3652	dbSNP
rs1458138221	3659	dbSNP
rs1033770554	3686	dbSNP
rs959412334	3687	dbSNP
rs992297106	3694	dbSNP
rs1278969108	3698	dbSNP
rs1222848563	3700	dbSNP
rs1347977171	3704	dbSNP
rs540560749	3709	dbSNP
rs918060845	3713	dbSNP
rs1240182690	3717	dbSNP
rs1382739782	3718	dbSNP
rs1335236780	3720	dbSNP
rs950991296	3732	dbSNP
rs970754996	3738	dbSNP
rs983706793	3740	dbSNP
rs1399142493	3746	dbSNP
rs1332172176	3750	dbSNP
rs1444037318	3754	dbSNP
rs1384552072	3756	dbSNP
rs1225831000	3764	dbSNP
rs1181668042	3768	dbSNP
rs1446294248	3769	dbSNP
rs1003510828	3779	dbSNP
rs1214696224	3793	dbSNP
rs1444948099	3794	dbSNP
rs908904342	3797	dbSNP
rs941703058	3804	dbSNP
rs1281779989	3805	dbSNP
rs576181373	3806	dbSNP
rs1039072581	3809	dbSNP
rs537230892	3813	dbSNP
rs1260212385	3818	dbSNP
rs921687431	3822	dbSNP
rs933028527	3825	dbSNP
rs959274720	3834	dbSNP
rs1051617900	3839	dbSNP
rs11549745	3841	dbSNP
rs1479722412	3851	dbSNP
rs891618447	3855	dbSNP
rs1195298872	3856	dbSNP
rs1268047369	3869	dbSNP
rs1363788493	3870	dbSNP
rs1425466629	3871	dbSNP
rs555409042	3874	dbSNP
rs562036881	3875	dbSNP
rs1197107298	3882	dbSNP
rs1243503325	3883	dbSNP
rs773569378	3885	dbSNP
rs1490062597	3888	dbSNP
rs573870860	3889	dbSNP
rs1477997585	3894	dbSNP
rs1134368	3895	dbSNP
rs1272868475	3899	dbSNP
rs1370950134	3902	dbSNP
rs1034065541	3903	dbSNP
rs1461101632	3911	dbSNP
rs1293588411	3914	dbSNP
rs868762860	3916	dbSNP
rs1343775517	3920	dbSNP
rs895252374	3923	dbSNP
rs1458440567	3927	dbSNP
rs1350404393	3928	dbSNP
rs369787015	3928	dbSNP
rs1015481693	3929	dbSNP
rs1170996164	3929	dbSNP
rs1425500683	3929	dbSNP
rs1407336900	3930	dbSNP
rs1479892811	3930	dbSNP
rs10572574	3931	dbSNP
rs1203034912	3931	dbSNP
rs1223232644	3931	dbSNP
rs1297606605	3931	dbSNP
rs1309678193	3931	dbSNP
rs1321712852	3931	dbSNP
rs1372686327	3931	dbSNP
rs1387439652	3931	dbSNP
rs1393014869	3931	dbSNP
rs1439894170	3931	dbSNP
rs1488481372	3931	dbSNP
rs36019402	3931	dbSNP
rs571590192	3931	dbSNP
rs74548623	3931	dbSNP
rs745669748	3931	dbSNP
rs749648819	3931	dbSNP
rs755895344	3931	dbSNP
rs756485098	3931	dbSNP
rs1301788006	3932	dbSNP
rs1345334981	3934	dbSNP
rs1219600454	3935	dbSNP
rs1298086702	3937	dbSNP
rs1305973637	3938	dbSNP
rs1226895212	3939	dbSNP
rs1013605540	3940	dbSNP
rs1361627726	3944	dbSNP
rs966919093	3945	dbSNP
rs1220190538	3946	dbSNP
rs1176038068	3948	dbSNP
rs79492261	3951	dbSNP
rs977888927	3951	dbSNP
rs1268063860	3952	dbSNP
rs1239279608	3953	dbSNP
rs1203441384	3954	dbSNP
rs1488515375	3954	dbSNP
rs1265297421	3955	dbSNP
rs1195565286	3957	dbSNP
rs1304930495	3960	dbSNP
rs1259299469	3961	dbSNP
rs1225490108	3968	dbSNP
rs911593930	3969	dbSNP
rs1427563889	3971	dbSNP
rs1451658429	3975	dbSNP
rs796213291	3988	dbSNP
rs1431595307	3992	dbSNP
rs974376501	3996	dbSNP
rs1344190854	4007	dbSNP
rs1156359052	4008	dbSNP
rs1440931459	4011	dbSNP
rs950876150	4021	dbSNP
rs984149647	4025	dbSNP
rs1016520791	4026	dbSNP
rs577958666	4066	dbSNP
rs974449328	4068	dbSNP
rs1048596650	4074	dbSNP
rs1201294166	4076	dbSNP
rs921576542	4081	dbSNP
rs1259142057	4082	dbSNP
rs1218891641	4084	dbSNP
rs1354426933	4092	dbSNP
rs1309957197	4094	dbSNP
rs933082504	4095	dbSNP
rs1162267541	4097	dbSNP
rs1365503632	4100	dbSNP
rs1401054226	4101	dbSNP
rs1286700102	4102	dbSNP
rs1360602269	4102	dbSNP
rs1360844443	4102	dbSNP
rs1380376727	4102	dbSNP
rs545402158	4102	dbSNP
rs552904611	4102	dbSNP
rs940145037	4102	dbSNP
rs1163551881	4104	dbSNP
rs1423265057	4105	dbSNP
rs1291015988	4108	dbSNP
rs1188716988	4113	dbSNP
rs1196095299	4113	dbSNP
rs1259928168	4113	dbSNP
rs1428216134	4113	dbSNP
rs1291109086	4114	dbSNP
rs1360225283	4114	dbSNP
rs1220293331	4115	dbSNP
rs1245264126	4116	dbSNP
rs1267077671	4116	dbSNP
rs1325628759	4116	dbSNP
rs1354205347	4116	dbSNP
rs1273294270	4117	dbSNP
rs1401429848	4119	dbSNP
rs1302011401	4121	dbSNP
rs1340649522	4121	dbSNP
rs1402507913	4123	dbSNP
rs1393520959	4125	dbSNP
rs1313646370	4127	dbSNP
rs559153122	4129	dbSNP
rs572434455	4129	dbSNP
rs1197372444	4131	dbSNP
rs1453343468	4131	dbSNP
rs1269447091	4132	dbSNP
rs187868895	4133	dbSNP
rs906602756	4133	dbSNP
rs1255892561	4135	dbSNP
rs1220185208	4137	dbSNP
rs1361744727	4137	dbSNP
rs913105000	4138	dbSNP
rs1394910652	4139	dbSNP
rs564580810	4139	dbSNP
rs565592167	4139	dbSNP
rs1333829233	4140	dbSNP
rs531843150	4141	dbSNP
rs1174530515	4142	dbSNP
rs550337228	4142	dbSNP
rs1199557489	4144	dbSNP
rs1437186292	4145	dbSNP
rs1200310919	4148	dbSNP
rs1236244054	4148	dbSNP
rs112007715	4150	dbSNP
rs149881846	4150	dbSNP
rs73419951	4150	dbSNP
rs562290359	4152	dbSNP
rs1312030861	4167	dbSNP
rs1405804058	4173	dbSNP
rs1055071933	4179	dbSNP
rs895138062	4180	dbSNP
rs1403119329	4181	dbSNP
rs1158100368	4185	dbSNP
rs865812963	4189	dbSNP
rs191607114	4190	dbSNP
rs1025010688	4196	dbSNP
rs1258778591	4197	dbSNP
rs886484323	4198	dbSNP
rs1440150859	4202	dbSNP
rs1005061013	4207	dbSNP
rs1182136360	4223	dbSNP
rs1257796645	4231	dbSNP
rs966573979	4242	dbSNP
rs1182434674	4243	dbSNP
rs1204055694	4254	dbSNP
rs1380319105	4264	dbSNP
rs551107753	4267	dbSNP
rs978296552	4268	dbSNP
rs1241468037	4271	dbSNP
rs1016815967	4280	dbSNP
rs1282817646	4281	dbSNP
rs1161860364	4283	dbSNP
rs557211964	4285	dbSNP
rs1341299831	4286	dbSNP
rs965748651	4293	dbSNP
rs569267461	4294	dbSNP
rs1418001710	4310	dbSNP
rs963680951	4311	dbSNP
rs1160421577	4316	dbSNP
rs867754880	4323	dbSNP
rs777238393	4324	dbSNP
rs921615202	4339	dbSNP
rs1453466072	4343	dbSNP
rs1237756227	4348	dbSNP
rs1028694465	4349	dbSNP
rs1385257736	4351	dbSNP
rs954354608	4352	dbSNP
rs1450613336	4356	dbSNP
rs746739187	4363	dbSNP
rs149268415	4365	dbSNP
rs867272698	4371	dbSNP
rs940236033	4377	dbSNP
rs945755896	4381	dbSNP
rs1037604498	4382	dbSNP
rs978633688	4384	dbSNP
rs1304758015	4387	dbSNP
rs925758456	4390	dbSNP
rs1316163654	4391	dbSNP
rs565354070	4392	dbSNP
rs1298904579	4400	dbSNP
rs937303134	4402	dbSNP
rs1055629014	4406	dbSNP
rs1404342658	4407	dbSNP
rs895189108	4408	dbSNP
rs1162588912	4418	dbSNP
rs1406946351	4424	dbSNP
rs1414213673	4429	dbSNP
rs143574336	4445	dbSNP
rs138089997	4446	dbSNP
rs939404949	4447	dbSNP
rs1055186365	4450	dbSNP
rs1193758747	4451	dbSNP
rs1459714773	4452	dbSNP
rs1245540249	4466	dbSNP
rs1046349268	4470	dbSNP
rs182192711	4476	dbSNP
rs1452585811	4477	dbSNP
rs1010875181	4484	dbSNP
rs76370822	4492	dbSNP
rs1279012572	4493	dbSNP
rs1238284468	4494	dbSNP
rs1365581661	4514	dbSNP
rs1291756521	4515	dbSNP
rs1438497478	4518	dbSNP
rs1350351230	4522	dbSNP
rs1470850070	4523	dbSNP
rs1463802697	4525	dbSNP
rs1005354631	4528	dbSNP
rs1037898942	4531	dbSNP
rs143763372	4532	dbSNP
rs375579804	4533	dbSNP
rs573933107	4546	dbSNP
rs1197162252	4547	dbSNP
rs1459361802	4557	dbSNP
rs1259026889	4563	dbSNP
rs996466912	4571	dbSNP
rs567307277	4572	dbSNP
rs1468433524	4575	dbSNP
rs1368222952	4578	dbSNP
rs770413008	4585	dbSNP
rs1336268521	4586	dbSNP
rs1029248810	4589	dbSNP
rs368578312	4604	dbSNP
rs147212266	4605	dbSNP
rs553275358	4606	dbSNP
rs745771518	4609	dbSNP
rs769677504	4613	dbSNP
rs978904747	4615	dbSNP
rs867341369	4621	dbSNP
rs1433191588	4626	dbSNP
rs1372515306	4634	dbSNP
rs756755513	4635	dbSNP
rs1177313205	4646	dbSNP
rs1441976517	4650	dbSNP
rs775521272	4653	dbSNP
rs780859583	4670	dbSNP
rs1239147335	4676	dbSNP
rs984855091	4681	dbSNP
rs925842110	4684	dbSNP
rs958782083	4686	dbSNP
rs910174080	4689	dbSNP
rs1316397894	4694	dbSNP
rs572498431	4700	dbSNP
rs1237831694	4702	dbSNP
rs972955599	4717	dbSNP
rs917173126	4725	dbSNP
rs1395194669	4727	dbSNP
rs949942225	4736	dbSNP
rs1304212630	4738	dbSNP
rs1321103942	4744	dbSNP
rs1046400790	4745	dbSNP
rs745442112	4753	dbSNP
rs907849935	4756	dbSNP
rs940816304	4764	dbSNP
rs762599982	4765	dbSNP
rs1422085907	4768	dbSNP
rs1258273860	4771	dbSNP
rs1439080778	4775	dbSNP
rs114526279	4776	dbSNP
rs996350306	4790	dbSNP
rs1258599243	4804	dbSNP
rs1182659546	4816	dbSNP
rs1488026479	4836	dbSNP
rs1261094948	4839	dbSNP
rs138066648	4846	dbSNP
rs1218815786	4850	dbSNP
rs1355801872	4853	dbSNP
rs1261167599	4857	dbSNP
rs1243808736	4858	dbSNP
rs58815341	4864	dbSNP
rs542780475	4883	dbSNP
rs1339391416	4887	dbSNP
rs763955103	4894	dbSNP
rs1401227062	4898	dbSNP
rs527279999	4901	dbSNP
rs1431935040	4923	dbSNP
rs140719350	4924	dbSNP
rs141394033	4955	dbSNP
rs999860526	4958	dbSNP
rs999987900	4959	dbSNP
rs1326952672	4961	dbSNP
rs1165811433	4962	dbSNP
rs1033177853	4963	dbSNP
rs958414676	4968	dbSNP
rs1421699449	4969	dbSNP
rs77771283	4970	dbSNP
rs1488623826	4971	dbSNP
rs150822635	4972	dbSNP
rs1209136785	4977	dbSNP
rs971311799	4989	dbSNP
rs1267020917	4993	dbSNP
rs762188007	4999	dbSNP
rs907905512	5010	dbSNP
rs940687382	5017	dbSNP
rs1220003463	5026	dbSNP
rs14143	5026	dbSNP
rs1404072806	5027	dbSNP
rs750573322	5034	dbSNP
rs1323525577	5039	dbSNP
rs920687704	5040	dbSNP
rs932028362	5045	dbSNP
rs1278513574	5058	dbSNP
rs1294516721	5065	dbSNP
rs951794670	5072	dbSNP
rs1050605759	5076	dbSNP
rs1212376838	5077	dbSNP
rs1271684096	5078	dbSNP
rs34136429	5092	dbSNP
rs377042579	5099	dbSNP
rs1377118734	5101	dbSNP
rs944974370	5107	dbSNP
rs1431400157	5111	dbSNP
rs961706755	5112	dbSNP
rs1223952666	5114	dbSNP
rs1271646275	5128	dbSNP
rs1457146932	5131	dbSNP
rs534174161	5131	dbSNP
rs111686176	5132	dbSNP
rs1000276396	5142	dbSNP
rs1339538267	5147	dbSNP
rs76718908	5148	dbSNP
rs188120654	5149	dbSNP
rs1333336379	5159	dbSNP
rs756297211	5165	dbSNP
rs766734731	5167	dbSNP
rs1398520872	5173	dbSNP
rs1333676219	5190	dbSNP
rs1166333026	5191	dbSNP
rs1401720006	5202	dbSNP
rs1418925968	5209	dbSNP
rs754372321	5218	dbSNP
rs1024122214	5219	dbSNP
rs79816012	5222	dbSNP
rs982760127	5229	dbSNP
rs368320969	5232	dbSNP
rs779388546	5234	dbSNP
rs1433026932	5245	dbSNP
rs1043788303	5257	dbSNP
rs1423834669	5265	dbSNP
rs746641512	5271	dbSNP
rs537650811	5291	dbSNP
rs1277394871	5292	dbSNP
rs1198245007	5296	dbSNP
rs1346489068	5306	dbSNP
rs1281747375	5315	dbSNP
rs1240031661	5322	dbSNP
rs1040275280	5325	dbSNP
rs1327909132	5326	dbSNP
rs1428248928	5328	dbSNP
rs901760061	5333	dbSNP
rs1332425244	5339	dbSNP
rs756942540	5340	dbSNP
rs1402959081	5349	dbSNP
rs920585839	5353	dbSNP
rs1050197993	5364	dbSNP
rs887557498	5370	dbSNP
rs1294661203	5372	dbSNP
rs772518805	5373	dbSNP
rs1160240230	5380	dbSNP
rs932082269	5397	dbSNP
rs773242770	5401	dbSNP
rs962017998	5405	dbSNP
rs1002511087	5407	dbSNP
rs1257631931	5408	dbSNP
rs1215212775	5410	dbSNP
rs1352158610	5413	dbSNP
rs1285434149	5414	dbSNP
rs986205280	5421	dbSNP
rs1288713685	5430	dbSNP
rs912103170	5433	dbSNP
rs530638787	5435	dbSNP
rs1282686067	5437	dbSNP
rs1450436633	5441	dbSNP
rs1035308228	5450	dbSNP
rs1297689465	5463	dbSNP
rs960947474	5467	dbSNP
rs1358563639	5469	dbSNP
rs1241709505	5478	dbSNP
rs1320190231	5486	dbSNP
rs1041854478	5502	dbSNP
rs192847728	5512	dbSNP
rs1161193198	5516	dbSNP
rs760900970	5516	dbSNP
rs936243831	5516	dbSNP
rs1473593834	5525	dbSNP
rs1023820426	5528	dbSNP
rs1192317756	5531	dbSNP
rs540235698	5531	dbSNP
rs35790825	5532	dbSNP
rs1288190817	5533	dbSNP
rs532475414	5533	dbSNP
rs67757795	5533	dbSNP
rs779264801	5533	dbSNP
rs35702301	5534	dbSNP
rs1230344265	5535	dbSNP
rs1335726937	5535	dbSNP
rs1277738893	5536	dbSNP
rs1054554561	5538	dbSNP
rs1216935724	5540	dbSNP
rs548769452	5549	dbSNP
rs976050830	5550	dbSNP
rs1423934596	5552	dbSNP
rs1321346338	5553	dbSNP
rs1349191114	5553	dbSNP
rs923214707	5556	dbSNP
rs1394841666	5560	dbSNP
rs116102034	5562	dbSNP
rs1476579614	5563	dbSNP
rs1024007275	5565	dbSNP
rs1386895076	5576	dbSNP
rs1186541162	5589	dbSNP
rs1478004234	5590	dbSNP
rs201147845	5590	dbSNP
rs1224249384	5605	dbSNP
rs1317284125	5616	dbSNP
rs906924732	5616	dbSNP
rs1004463614	5618	dbSNP
rs1454197594	5631	dbSNP
rs550927580	5634	dbSNP
rs1366836125	5635	dbSNP
rs1381356200	5640	dbSNP
rs111608506	5650	dbSNP
rs1330324235	5650	dbSNP
rs1371427540	5650	dbSNP
rs1463753156	5659	dbSNP
rs962971585	5664	dbSNP
rs1355878377	5665	dbSNP
rs1036530548	5673	dbSNP
rs534787199	5675	dbSNP
rs780852991	5681	dbSNP
rs1280628373	5684	dbSNP
rs1196048854	5685	dbSNP
rs1455010284	5687	dbSNP
rs1027689427	5688	dbSNP
rs1203747960	5689	dbSNP
rs953355117	5695	dbSNP
rs986089347	5696	dbSNP
rs1177118693	5709	dbSNP
rs911988466	5743	dbSNP
rs1035339240	5746	dbSNP
rs1283892767	5748	dbSNP
rs1461949523	5760	dbSNP
rs894115472	5780	dbSNP
rs866479137	5791	dbSNP

- Genes & development, 2011

MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.

- Genes & development, 2013

When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.