miRTarBase - #MIRT540203


—
pre-miRNA Information
pre-miRNA hsa-mir-4421   
Genomic Coordinates chr1: 51059837 - 51059905
Description Homo sapiens miR-4421 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4421
Sequence 43| ACCUGUCUGUGGAAAGGAGCUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1222858590 1 dbSNP
rs1334405255 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ARHGAP18   
Synonyms MacGAP, SENEX, bA307O14.2
Description Rho GTPase activating protein 18
Transcript NM_033515   
Expression
Putative miRNA Targets on ARHGAP18
3'UTR of ARHGAP18
(miRNA target sites are highlighted)		 
>ARHGAP18|NM_033515|3'UTR
   1 AAGACTTAACAAGCTGCAGATAACCATGTGGACTTCTGTCATAATTCTTGCTGAGTCAAGAGTGTAAATAAAAGAAATGG
  81 CAGGACTCATATTATTCAGTTGTACCCAAGTATTTAAAAATGACTCTCTTAAGCCTTAAAAAGTCATAGATTTGTGCTGC
 161 TGCCAGAATTATATTAATTATTATTAATGTTATTATTAGAAAAAAAATTTCTGGAGTGAGAGTAAAGAGGCTTAATTAGT
 241 TTGTGGGCAGTTTTCATATGCTCTGTGAAATGTGTCCAGATGTGACATAGTTTTTTTTTTTAATATGTGGAAATGTCTTC
 321 TCTTCCCATTCTTTTCTCCTAAAATCATATATACTGTAATATATGCTCTCTCACCTCTATTACCTCCTCACATCTACCCT
 401 TTCCCAGTTAGGTTTGCTTTTTGACCAAAAAGATAACAAATACCAGGTATGGCAAGTTGTGAAGACAGCACATTAAAACA
 481 TACCTAATTTCACAGTATTCCTGTCACGACAGAATGTTAGTATTCATCTCTTTGAATCATTTGCTCAAATAATAACATTC
 561 CACCTTTTCCTGCTGTATCACAGGAAGTGATTTGCATTTTTTTTCAGTTCATCTGACTTATGTTCACAGAACCGTATCAG
 641 CGACCAAGAAAATAGGACTGTCAGAAGCTGCCAGTTATTACTGAACCATTAAATACTTATATACTAAGAATAAATAAAAT
 721 ATACCCATGTGAAATAATAATTGGATTATGGATAACAAGAGAGTGAAAGCCAAAGCACTTTCTGTCTACTGTACTCTTCT
 801 AAATGGAATTTTAAAAGTCATAGCTGGCTTTACGTGTTGTCATTATTAGCATTATAAATATGCATGATAGTATAATCCAG
 881 TAATGGTTGAAGAATGTATTTTACTTAAAGAGGGATTTTTTTTTTTAAGTCCTGAATAAGTCTACTGGAAGAATTATTCT
 961 TCTGGGTGAAAAAGCTTTTGTTTGTGTTCTTATTTTAAATAATCGGAGTCAATTTATTAAAATGTTCTTGAAAGTACTAT
1041 TCCCAGGGATTTTAATGCACAAACCATATTGTGACAAGAGATGAGCCTCTGTACTGTAAATAAGAAATGAAGTAGAGAAA
1121 TGTTAAATATTTTATGAGTTTAGAATATAGTAAATAAAAGGTGATGTAAATGAATGCTGCACAAACGGTGTTCATGATAC
1201 TTTTAGTAGTACTTTAGGAAAAACTACACATTCTCAGAAGCTCTTGATGTCTCTAATGAAGGGGGGGAATGCTGTTAATG
1281 AGAACAGTCATAAATTTTTAGCATATAATTACAAGAACAGCCTGTGGATATGATCACTTAAATGATTTTGTGGTGATTCG
1361 TGCCATTGCTTTTTTATTTAAAAGAAAATTTTGTAATTAAATGCCTTTTTCTAAATTAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucgaggaAAGGUGUCUGUCca 5'
                  || :: ||||||  
Target 5' atggcaagTTGTGAAGACAGca 3'
 449 - 470 126.00 -9.10
2 
miRNA  3' aucgaGGAAAGGUGUCUGUCCa 5'
               ||||||| ||| :||| 
Target 5' tctacCCTTTCC-CAGTTAGGt 3'
 393 - 413 124.00 -20.90
3 
miRNA  3' aucGAGGAAAG-GUGUCUGUCca 5'
             :|||| || |   |||||  
Target 5' gtaTTCCTGTCAC---GACAGaa 3'
 495 - 514 107.00 -15.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31558528 2 COSMIC
COSN30189927 3 COSMIC
COSN30123317 5 COSMIC
COSN31574059 19 COSMIC
COSN6303402 25 COSMIC
COSN22276410 47 COSMIC
COSN30144715 69 COSMIC
COSN28681429 70 COSMIC
COSN30522269 125 COSMIC
COSN30143285 131 COSMIC
COSN17075797 152 COSMIC
COSN31568733 166 COSMIC
COSN20103347 190 COSMIC
COSN25335072 325 COSMIC
COSN28201557 346 COSMIC
COSN25278478 519 COSMIC
COSN18810477 562 COSMIC
COSN27294370 916 COSMIC
COSN24737820 1123 COSMIC
COSN20716619 1235 COSMIC
COSN17683935 1585 COSMIC
COSN20369186 1737 COSMIC
COSN29178512 1768 COSMIC
COSN29542413 1802 COSMIC
COSN23431091 2006 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1239437685 13 dbSNP
rs773792900 14 dbSNP
rs1347793150 16 dbSNP
rs774573467 18 dbSNP
rs770424811 20 dbSNP
rs762920471 24 dbSNP
rs537118596 26 dbSNP
rs769601753 29 dbSNP
rs1419143908 33 dbSNP
rs747861313 39 dbSNP
rs1477045126 41 dbSNP
rs1265668963 44 dbSNP
rs1194143002 46 dbSNP
rs753113679 47 dbSNP
rs776920237 51 dbSNP
rs1038505965 59 dbSNP
rs759753616 77 dbSNP
rs1248457696 80 dbSNP
rs764901787 82 dbSNP
rs908801317 84 dbSNP
rs1210338792 88 dbSNP
rs533476180 89 dbSNP
rs1208962578 90 dbSNP
rs992159685 94 dbSNP
rs951502616 99 dbSNP
rs939373225 100 dbSNP
rs559439723 106 dbSNP
rs1197932192 112 dbSNP
rs1378093346 122 dbSNP
rs547808379 125 dbSNP
rs536701101 130 dbSNP
rs1411310826 142 dbSNP
rs1457894859 145 dbSNP
rs1322728198 154 dbSNP
rs1388860611 158 dbSNP
rs1016342211 164 dbSNP
rs1298496215 165 dbSNP
rs1324586932 169 dbSNP
rs529340512 172 dbSNP
rs968127057 173 dbSNP
rs1366516691 175 dbSNP
rs1228486248 181 dbSNP
rs1323021398 187 dbSNP
rs561146429 188 dbSNP
rs1007259367 195 dbSNP
rs111625877 199 dbSNP
rs1303644826 206 dbSNP
rs1030163834 208 dbSNP
rs1179918205 208 dbSNP
rs1453168349 208 dbSNP
rs1250990807 213 dbSNP
rs1472923373 214 dbSNP
rs542965893 216 dbSNP
rs1366839635 220 dbSNP
rs548363812 221 dbSNP
rs118086339 222 dbSNP
rs1393324876 223 dbSNP
rs1428229363 225 dbSNP
rs567579596 239 dbSNP
rs1351669809 246 dbSNP
rs1390698941 263 dbSNP
rs989995145 272 dbSNP
rs1409860567 274 dbSNP
rs182548046 276 dbSNP
rs1308478967 278 dbSNP
rs1338240153 282 dbSNP
rs1052247605 290 dbSNP
rs955967248 301 dbSNP
rs1265730491 302 dbSNP
rs1394796994 302 dbSNP
rs1190349950 305 dbSNP
rs1202776252 306 dbSNP
rs1032027287 307 dbSNP
rs1273758460 310 dbSNP
rs1483326832 314 dbSNP
rs544733751 320 dbSNP
rs768295028 323 dbSNP
rs775243494 326 dbSNP
rs1423388671 341 dbSNP
rs1045565825 355 dbSNP
rs1370432936 363 dbSNP
rs577666040 371 dbSNP
rs117685592 372 dbSNP
rs1027955220 379 dbSNP
rs996516501 380 dbSNP
rs1371602522 383 dbSNP
rs1432145250 386 dbSNP
rs1260707515 390 dbSNP
rs917941804 392 dbSNP
rs1394948322 394 dbSNP
rs540605992 399 dbSNP
rs898270547 400 dbSNP
rs1312910805 402 dbSNP
rs1384568272 406 dbSNP
rs1225779629 412 dbSNP
rs1484005234 415 dbSNP
rs1342684364 421 dbSNP
rs1056705042 424 dbSNP
rs1038472853 425 dbSNP
rs566010492 426 dbSNP
rs918742428 427 dbSNP
rs148391354 436 dbSNP
rs1258483803 440 dbSNP
rs1447854240 443 dbSNP
rs1188221312 444 dbSNP
rs1232896122 446 dbSNP
rs555608903 459 dbSNP
rs537362192 472 dbSNP
rs887350469 478 dbSNP
rs1451791335 480 dbSNP
rs908926118 481 dbSNP
rs1057158029 491 dbSNP
rs1377568353 494 dbSNP
rs566787231 495 dbSNP
rs1302949483 496 dbSNP
rs13213236 507 dbSNP
rs558333838 508 dbSNP
rs1432434365 515 dbSNP
rs1319556664 526 dbSNP
rs146179029 531 dbSNP
rs953048805 538 dbSNP
rs566154372 544 dbSNP
rs547939834 549 dbSNP
rs1029967081 551 dbSNP
rs1233932487 552 dbSNP
rs926571000 553 dbSNP
rs1045109366 554 dbSNP
rs143201026 562 dbSNP
rs1208339708 573 dbSNP
rs1248883208 574 dbSNP
rs371455695 575 dbSNP
rs1487019448 578 dbSNP
rs915355777 582 dbSNP
rs989979446 587 dbSNP
rs1030788703 594 dbSNP
rs956105266 600 dbSNP
rs1430783517 605 dbSNP
rs546948534 605 dbSNP
rs568481387 611 dbSNP
rs1432590522 618 dbSNP
rs1430484665 621 dbSNP
rs1372413315 629 dbSNP
rs549258695 633 dbSNP
rs771504990 634 dbSNP
rs1387265193 635 dbSNP
rs1285185653 639 dbSNP
rs532853509 641 dbSNP
rs189523254 642 dbSNP
rs1372319218 643 dbSNP
rs6913331 644 dbSNP
rs139853137 656 dbSNP
rs1016662831 660 dbSNP
rs780889806 664 dbSNP
rs1219691111 674 dbSNP
rs896478367 676 dbSNP
rs1489052126 681 dbSNP
rs1202144207 683 dbSNP
rs1254941435 688 dbSNP
rs1004383302 704 dbSNP
rs1180869542 707 dbSNP
rs1209608170 719 dbSNP
rs1402063667 720 dbSNP
rs565089869 724 dbSNP
rs1162329487 725 dbSNP
rs1056504831 726 dbSNP
rs930210744 727 dbSNP
rs185147825 741 dbSNP
rs897447120 749 dbSNP
rs887309084 754 dbSNP
rs1039032421 755 dbSNP
rs1203678664 757 dbSNP
rs1056637497 759 dbSNP
rs1375697844 761 dbSNP
rs1226822382 763 dbSNP
rs941497960 764 dbSNP
rs562076398 770 dbSNP
rs541824731 771 dbSNP
rs386705765 772 dbSNP
rs931752827 778 dbSNP
rs184005307 779 dbSNP
rs1292911135 782 dbSNP
rs1232940297 783 dbSNP
rs1410606162 784 dbSNP
rs1352430751 791 dbSNP
rs1179680395 793 dbSNP
rs946721554 797 dbSNP
rs1306217886 801 dbSNP
rs1408177012 802 dbSNP
rs975759181 805 dbSNP
rs915323259 806 dbSNP
rs540746542 807 dbSNP
rs1428998950 808 dbSNP
rs192057503 815 dbSNP
rs979777057 816 dbSNP
rs573265661 818 dbSNP
rs1283771105 825 dbSNP
rs1380209205 827 dbSNP
rs1248496618 832 dbSNP
rs554950379 833 dbSNP
rs1206492485 834 dbSNP
rs1159812102 835 dbSNP
rs1438983364 836 dbSNP
rs1012316831 842 dbSNP
rs924402227 852 dbSNP
rs1236492086 861 dbSNP
rs986672382 869 dbSNP
rs186964684 872 dbSNP
rs543800350 873 dbSNP
rs576668812 877 dbSNP
rs962394127 880 dbSNP
rs145975637 892 dbSNP
rs982899666 898 dbSNP
rs181883768 907 dbSNP
rs1333558182 913 dbSNP
rs1268664480 914 dbSNP
rs1035568956 915 dbSNP
rs1219195047 927 dbSNP
rs1318862608 927 dbSNP
rs200125362 927 dbSNP
rs530758927 927 dbSNP
rs60420681 927 dbSNP
rs1003743511 931 dbSNP
rs1212086323 936 dbSNP
rs190280860 943 dbSNP
rs1023929956 944 dbSNP
rs1323693817 947 dbSNP
rs1050371352 963 dbSNP
rs1245832877 964 dbSNP
rs931728668 965 dbSNP
rs923057716 967 dbSNP
rs1243674110 972 dbSNP
rs1010902704 973 dbSNP
rs1171987632 975 dbSNP
rs975808161 980 dbSNP
rs1331446581 992 dbSNP
rs1470999086 999 dbSNP
rs531706123 1004 dbSNP
rs78506382 1005 dbSNP
rs1441545883 1012 dbSNP
rs1329756706 1034 dbSNP
rs1335165906 1039 dbSNP
rs1275969497 1043 dbSNP
rs1224848756 1047 dbSNP
rs535964199 1057 dbSNP
rs1265810550 1066 dbSNP
rs1328013442 1069 dbSNP
rs1205407411 1073 dbSNP
rs1286071893 1082 dbSNP
rs1449723236 1085 dbSNP
rs1197997003 1089 dbSNP
rs746571825 1092 dbSNP
rs1269535044 1105 dbSNP
rs1324128759 1108 dbSNP
rs1481430966 1109 dbSNP
rs1180146301 1112 dbSNP
rs779442659 1115 dbSNP
rs1388382821 1120 dbSNP
rs1454479366 1134 dbSNP
rs1392045158 1136 dbSNP
rs1389016280 1137 dbSNP
rs1405156776 1138 dbSNP
rs935391976 1145 dbSNP
rs1304233036 1149 dbSNP
rs1347974653 1165 dbSNP
rs1408583270 1166 dbSNP
rs1285886040 1176 dbSNP
rs568419607 1186 dbSNP
rs979360994 1187 dbSNP
rs890560118 1188 dbSNP
rs1457492918 1193 dbSNP
rs1353921571 1195 dbSNP
rs550197790 1197 dbSNP
rs542025867 1198 dbSNP
rs1490811130 1201 dbSNP
rs1469187061 1203 dbSNP
rs933851550 1211 dbSNP
rs1035062294 1213 dbSNP
rs531652109 1225 dbSNP
rs1246726352 1227 dbSNP
rs980257208 1249 dbSNP
rs1164577180 1255 dbSNP
rs1472653663 1255 dbSNP
rs569919863 1262 dbSNP
rs1308035384 1263 dbSNP
rs551412735 1264 dbSNP
rs1391475532 1267 dbSNP
rs1005783053 1268 dbSNP
rs1308632438 1268 dbSNP
rs890072671 1269 dbSNP
rs1049915144 1273 dbSNP
rs1273829255 1278 dbSNP
rs1480974403 1303 dbSNP
rs533118248 1305 dbSNP
rs368488473 1309 dbSNP
rs76725375 1318 dbSNP
rs778390994 1323 dbSNP
rs909514371 1324 dbSNP
rs1184501899 1330 dbSNP
rs1387468310 1331 dbSNP
rs1448051906 1335 dbSNP
rs1282415718 1336 dbSNP
rs1223362985 1342 dbSNP
rs1374164935 1343 dbSNP
rs11544373 1344 dbSNP
rs1299355056 1356 dbSNP
rs1276636550 1357 dbSNP
rs528958448 1359 dbSNP
rs1337056604 1360 dbSNP
rs1235383004 1362 dbSNP
rs935112140 1363 dbSNP
rs923614833 1368 dbSNP
rs1307977906 1369 dbSNP
rs1325044346 1375 dbSNP
rs561492298 1390 dbSNP
rs755184460 1394 dbSNP
rs946648792 1403 dbSNP
rs1323007797 1413 dbSNP
rs1390481206 1416 dbSNP
rs1315804180 1422 dbSNP
rs951192382 1424 dbSNP
rs1463785646 1425 dbSNP
rs1399707295 1427 dbSNP
rs1425300053 1428 dbSNP
rs1262917449 1438 dbSNP
rs149500865 1442 dbSNP
rs916451883 1444 dbSNP
rs982271380 1456 dbSNP
rs1468835387 1459 dbSNP
rs990736069 1460 dbSNP
rs1173788870 1461 dbSNP
rs1407887444 1463 dbSNP
rs41285294 1476 dbSNP
rs1023815506 1478 dbSNP
rs564773625 1479 dbSNP
rs1344900721 1480 dbSNP
rs1383847766 1480 dbSNP
rs35010083 1480 dbSNP
rs397737567 1480 dbSNP
rs961783289 1481 dbSNP
rs1016933224 1487 dbSNP
rs138039665 1490 dbSNP
rs1215396154 1491 dbSNP
rs1261665062 1492 dbSNP
rs1487090594 1495 dbSNP
rs1240663980 1497 dbSNP
rs1215354480 1500 dbSNP
rs1199472308 1506 dbSNP
rs1479794751 1506 dbSNP
rs1430859673 1512 dbSNP
rs1031394035 1520 dbSNP
rs1443171703 1521 dbSNP
rs369024980 1523 dbSNP
rs150785533 1525 dbSNP
rs554410133 1532 dbSNP
rs1208806735 1535 dbSNP
rs1345726618 1539 dbSNP
rs1302594468 1545 dbSNP
rs1028970780 1551 dbSNP
rs558265359 1557 dbSNP
rs1285247861 1570 dbSNP
rs998408151 1580 dbSNP
rs756334107 1585 dbSNP
rs113572799 1586 dbSNP
rs574979073 1591 dbSNP
rs1219851253 1601 dbSNP
rs556732278 1602 dbSNP
rs181349835 1610 dbSNP
rs1359358077 1611 dbSNP
rs902297749 1621 dbSNP
rs1043492894 1628 dbSNP
rs1432320355 1638 dbSNP
rs1039529577 1644 dbSNP
rs1374251052 1648 dbSNP
rs1169795138 1665 dbSNP
rs1451821633 1668 dbSNP
rs1417847804 1671 dbSNP
rs1186275554 1677 dbSNP
rs141344897 1678 dbSNP
rs909829196 1680 dbSNP
rs982836198 1682 dbSNP
rs1368707094 1684 dbSNP
rs1185998350 1685 dbSNP
rs551615836 1692 dbSNP
rs758444205 1702 dbSNP
rs1441576813 1714 dbSNP
rs916265182 1719 dbSNP
rs1055018111 1721 dbSNP
rs939275991 1722 dbSNP
rs929694782 1727 dbSNP
rs188150005 1730 dbSNP
rs1273122920 1731 dbSNP
rs961475226 1741 dbSNP
rs1203248414 1742 dbSNP
rs1309154869 1744 dbSNP
rs1270681513 1760 dbSNP
rs981822752 1761 dbSNP
rs1213759237 1763 dbSNP
rs1379525153 1766 dbSNP
rs1281288502 1770 dbSNP
rs909922723 1774 dbSNP
rs1294749626 1781 dbSNP
rs113680268 1782 dbSNP
rs1165326325 1782 dbSNP
rs1417320023 1782 dbSNP
rs1171201587 1784 dbSNP
rs750381033 1787 dbSNP
rs916728838 1788 dbSNP
rs1336332126 1794 dbSNP
rs1383912025 1794 dbSNP
rs1354288520 1797 dbSNP
rs765323194 1802 dbSNP
rs761853115 1807 dbSNP
rs183919403 1809 dbSNP
rs554271856 1810 dbSNP
rs367631564 1813 dbSNP
rs193230540 1814 dbSNP
rs1308816764 1817 dbSNP
rs1353259170 1827 dbSNP
rs1242156291 1828 dbSNP
rs1170273008 1831 dbSNP
rs753618856 1843 dbSNP
rs561430985 1844 dbSNP
rs996179183 1847 dbSNP
rs114073692 1848 dbSNP
rs759662636 1849 dbSNP
rs998946589 1851 dbSNP
rs1421662841 1856 dbSNP
rs1474980238 1866 dbSNP
rs1468311279 1872 dbSNP
rs904694177 1873 dbSNP
rs1407154099 1889 dbSNP
rs1022438908 1902 dbSNP
rs1252680957 1906 dbSNP
rs1326267998 1912 dbSNP
rs1432100651 1915 dbSNP
rs1184411970 1917 dbSNP
rs777445618 1917 dbSNP
rs1363379174 1926 dbSNP
rs1010667061 1932 dbSNP
rs1039498401 1933 dbSNP
rs1481608520 1934 dbSNP
rs763827652 1935 dbSNP
rs1205243542 1940 dbSNP
rs138971307 1959 dbSNP
rs1054817645 1961 dbSNP
rs1193739144 1967 dbSNP
rs1203653088 1968 dbSNP
rs888358898 1972 dbSNP
rs939246602 1973 dbSNP
rs563936154 1980 dbSNP
rs1036957385 1988 dbSNP
rs929887874 1989 dbSNP
rs927611194 1991 dbSNP
rs1320794266 1995 dbSNP
rs535962790 1999 dbSNP
rs1404922342 2001 dbSNP
rs546430761 2004 dbSNP
rs1288498631 2005 dbSNP
rs1392624518 2013 dbSNP
rs1224898595 2023 dbSNP
rs1277424378 2024 dbSNP
rs1349622869 2025 dbSNP
rs947758817 2029 dbSNP
rs1205537990 2039 dbSNP
rs916365176 2044 dbSNP
rs572776603 2050 dbSNP
rs1269686695 2056 dbSNP
rs1490861269 2057 dbSNP
rs976757067 2060 dbSNP
rs1363462789 2061 dbSNP
rs1470693996 2062 dbSNP
rs753115615 2066 dbSNP
rs565899088 2067 dbSNP
rs1397182807 2068 dbSNP
rs1383829196 2073 dbSNP
rs958270341 2077 dbSNP
rs1424583111 2084 dbSNP
rs147032368 2086 dbSNP
rs1461168121 2097 dbSNP
rs1365599167 2100 dbSNP
rs141576097 2102 dbSNP
rs775054997 2103 dbSNP
rs1417407613 2104 dbSNP
rs1021821015 2105 dbSNP
rs955133193 2109 dbSNP
rs1030260218 2110 dbSNP
rs1488741240 2119 dbSNP
rs1245069288 2120 dbSNP
rs996161352 2122 dbSNP
rs1211561456 2136 dbSNP
rs1467807706 2137 dbSNP
rs1194181783 2144 dbSNP
rs1268377646 2145 dbSNP
rs964746887 2155 dbSNP
rs1240673849 2157 dbSNP
rs1314642088 2158 dbSNP
rs1033336603 2162 dbSNP
rs1305624429 2170 dbSNP
rs1016341785 2178 dbSNP
rs796812841 2183 dbSNP
rs1005788180 2185 dbSNP
rs1324368378 2190 dbSNP
rs1165632522 2193 dbSNP
rs1395220225 2197 dbSNP
rs1391605851 2209 dbSNP
rs1332953221 2216 dbSNP
rs551491295 2216 dbSNP
rs1380225503 2217 dbSNP
rs888250592 2225 dbSNP
rs1047338112 2228 dbSNP
rs1315596313 2235 dbSNP
rs771580885 2242 dbSNP
rs139113766 2245 dbSNP
rs1225212272 2246 dbSNP
rs1250815855 2264 dbSNP
rs994074774 2271 dbSNP
rs1343322949 2275 dbSNP
rs532871101 2285 dbSNP
rs1261523768 2287 dbSNP
rs906464103 2293 dbSNP
rs1046085762 2294 dbSNP
rs556664808 2302 dbSNP
rs1184562702 2303 dbSNP
rs6901510 2307 dbSNP
rs916332824 2308 dbSNP
rs190569016 2318 dbSNP
rs1048264547 2323 dbSNP
rs1462059812 2323 dbSNP
rs142202741 2324 dbSNP
rs558681048 2329 dbSNP
rs932721807 2331 dbSNP
rs921315866 2341 dbSNP
rs936426349 2342 dbSNP
rs1381146716 2348 dbSNP
rs1380451993 2354 dbSNP
rs1327051434 2355 dbSNP
rs1454692381 2355 dbSNP
rs538914184 2360 dbSNP
rs1220579248 2365 dbSNP
rs978685418 2377 dbSNP
rs933574366 2382 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 93663.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aucgaggaAAGGUGUCUGUCCa 5'
                  ||::| ||||||| 
Target 5' --------UUUUAGAGACAGGg 3'
 		1 - 14
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000368149.2 | 3UTR | UUUUAGAGACAGGGUCUUGCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
151 hsa-miR-4421 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT293805 FEM1A fem-1 homolog A 2 2
MIRT468824 RSRC2 arginine and serine rich coiled-coil 2 2 6
MIRT470326 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT474293 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT480821 BLCAP bladder cancer associated protein 2 10
MIRT496455 N6AMT1 N-6 adenine-specific DNA methyltransferase 1 2 2
MIRT500021 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT508622 PLA2G2C phospholipase A2 group IIC 2 2
MIRT514258 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT514574 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 4
MIRT515040 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515686 TFPI tissue factor pathway inhibitor 2 2
MIRT517385 METTL7A methyltransferase like 7A 2 4
MIRT519320 TIMELESS timeless circadian clock 2 2
MIRT519728 ZNF460 zinc finger protein 460 2 2
MIRT520243 USP9X ubiquitin specific peptidase 9, X-linked 2 4
MIRT520266 URGCP upregulator of cell proliferation 2 2
MIRT523695 FHL2 four and a half LIM domains 2 2 4
MIRT525357 HPR haptoglobin-related protein 2 2
MIRT530203 ALX1 ALX homeobox 1 2 2
MIRT530217 UGDH UDP-glucose 6-dehydrogenase 2 2
MIRT539888 IRGQ immunity related GTPase Q 2 2
MIRT540203 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT540544 MYO1H myosin IH 2 2
MIRT540946 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541928 ORC1 origin recognition complex subunit 1 2 4
MIRT542086 IKZF3 IKAROS family zinc finger 3 2 2
MIRT542191 FUT1 fucosyltransferase 1 (H blood group) 2 6
MIRT542342 LIMD1 LIM domains containing 1 2 2
MIRT542499 WDR13 WD repeat domain 13 2 2
MIRT542571 ZNF280B zinc finger protein 280B 2 2
MIRT542706 RPS15A ribosomal protein S15a 2 2
MIRT542902 HSBP1 heat shock factor binding protein 1 2 2
MIRT557044 HOXB3 homeobox B3 2 2
MIRT559285 AURKA aurora kinase A 2 2
MIRT563692 RPS26 ribosomal protein S26 2 2
MIRT564324 CCNT1 cyclin T1 2 2
MIRT573774 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT576319 Zfp703 zinc finger protein 703 1 1
MIRT576660 Fam216a family with sequence similarity 216, member A 2 2
MIRT609117 ZNF703 zinc finger protein 703 2 7
MIRT609183 DPY19L3 dpy-19 like C-mannosyltransferase 3 2 4
MIRT610539 FAM46A family with sequence similarity 46 member A 2 4
MIRT611598 JAKMIP3 Janus kinase and microtubule interacting protein 3 2 4
MIRT618036 CTU1 cytosolic thiouridylase subunit 1 2 2
MIRT622442 RNF217 ring finger protein 217 2 2
MIRT622562 PTPN3 protein tyrosine phosphatase, non-receptor type 3 2 2
MIRT623831 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT624397 CD3D CD3d molecule 2 2
MIRT627578 SLC24A4 solute carrier family 24 member 4 2 2
MIRT627862 PITPNM3 PITPNM family member 3 2 2
MIRT631108 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631115 ATCAY ATCAY, caytaxin 2 2
MIRT631204 ZNF724P zinc finger protein 724 2 2
MIRT631454 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT632347 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633901 FGF10 fibroblast growth factor 10 2 2
MIRT634398 PLSCR1 phospholipid scramblase 1 2 2
MIRT634924 CHMP1B charged multivesicular body protein 1B 2 2
MIRT635867 SLC11A2 solute carrier family 11 member 2 2 2
MIRT636633 CHAF1B chromatin assembly factor 1 subunit B 2 2
MIRT637153 PCDHA6 protocadherin alpha 6 2 2
MIRT640789 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT645416 FAM110A family with sequence similarity 110 member A 2 2
MIRT645530 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT647100 GNL3L G protein nucleolar 3 like 2 2
MIRT649262 IMPA2 inositol monophosphatase 2 2 2
MIRT650491 UFM1 ubiquitin fold modifier 1 2 2
MIRT650795 GSR glutathione-disulfide reductase 2 2
MIRT651039 ZNF652 zinc finger protein 652 2 2
MIRT654018 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT655523 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657308 HOXA9 homeobox A9 2 2
MIRT657789 GK5 glycerol kinase 5 (putative) 2 4
MIRT659400 CORO2A coronin 2A 2 2
MIRT659992 C2CD2L C2CD2 like 2 2
MIRT661391 RHCG Rh family C glycoprotein 2 2
MIRT662013 ZNF445 zinc finger protein 445 2 2
MIRT664012 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT664052 KIAA1551 KIAA1551 2 2
MIRT667065 PAOX polyamine oxidase 2 2
MIRT669160 CCNG1 cyclin G1 2 2
MIRT669650 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT673233 KLHDC8A kelch domain containing 8A 2 2
MIRT680480 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT683571 CARD8 caspase recruitment domain family member 8 2 2
MIRT683816 CBS cystathionine-beta-synthase 2 2
MIRT684555 ZNF708 zinc finger protein 708 2 2
MIRT685418 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT686046 SLC5A5 solute carrier family 5 member 5 2 2
MIRT686135 B4GALT7 beta-1,4-galactosyltransferase 7 2 2
MIRT686799 SOX12 SRY-box 12 2 2
MIRT687477 NHLRC2 NHL repeat containing 2 2 2
MIRT687951 HHIP hedgehog interacting protein 2 2
MIRT688178 FRRS1 ferric chelate reductase 1 2 2
MIRT688300 FAM208A family with sequence similarity 208 member A 2 2
MIRT688895 C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2 2
MIRT689199 ZNF574 zinc finger protein 574 2 2
MIRT690854 PVR poliovirus receptor 2 2
MIRT691258 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT692923 EXOSC2 exosome component 2 2 2
MIRT693625 CENPL centromere protein L 2 2
MIRT694994 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT695368 PHAX phosphorylated adaptor for RNA export 2 2
MIRT696626 WDR77 WD repeat domain 77 2 2
MIRT696686 APOC3 apolipoprotein C3 2 2
MIRT697364 ZNF394 zinc finger protein 394 2 2
MIRT697609 XIAP X-linked inhibitor of apoptosis 2 2
MIRT697733 USP6NL USP6 N-terminal like 2 2
MIRT697785 UBXN7 UBX domain protein 7 2 2
MIRT698357 TMEM127 transmembrane protein 127 2 2
MIRT698484 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT699855 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT704344 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT704595 CLN8 CLN8, transmembrane ER and ERGIC protein 2 2
MIRT705845 AHCY adenosylhomocysteinase 2 2
MIRT706305 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT707090 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT707138 TRA2B transformer 2 beta homolog 2 2
MIRT707150 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT707240 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT707352 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT707456 PPFIBP1 PPFIA binding protein 1 2 2
MIRT707499 AXL AXL receptor tyrosine kinase 2 2
MIRT707643 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT707696 FAM118A family with sequence similarity 118 member A 2 2
MIRT707711 CDC6 cell division cycle 6 2 2
MIRT707822 TMEM170A transmembrane protein 170A 2 2
MIRT707963 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT708002 NUDT4 nudix hydrolase 4 2 2
MIRT708031 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT708065 LIX1L limb and CNS expressed 1 like 2 2
MIRT708197 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT708206 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT711531 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT712637 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713697 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT714244 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT714397 FBXO31 F-box protein 31 2 2
MIRT714626 KIAA1143 KIAA1143 2 2
MIRT714911 CHMP3 charged multivesicular body protein 3 2 2
MIRT715568 EPHB4 EPH receptor B4 2 2
MIRT715846 SZT2 SZT2, KICSTOR complex subunit 2 2
MIRT716321 SIGLEC10 sialic acid binding Ig like lectin 10 2 2
MIRT718142 PALM paralemmin 2 2
MIRT720737 ELOVL7 ELOVL fatty acid elongase 7 2 2
MIRT722174 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT723223 FMNL3 formin like 3 2 2
MIRT723518 SIGLEC8 sialic acid binding Ig like lectin 8 2 2
MIRT724796 C1D C1D nuclear receptor corepressor 2 2
MIRT725280 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4421 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4421 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4421 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4421 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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