miRTarBase - #MIRT540580


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pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol CEP89   
Synonyms CCDC123, CEP123
Description centrosomal protein 89
Transcript NM_032816   
Expression
Putative miRNA Targets on CEP89
3'UTR of CEP89
(miRNA target sites are highlighted)		 
>CEP89|NM_032816|3'UTR
   1 AATCTGCGGGAGCCCGTGGTGTAGCCTCCTCTGGCCTGAAAGGTCTGCCTCACACAGGCCTTCCCTGCAGGGCAGCCCAT
  81 GGTGGCAGCCGGAGGTGCGTAAGCCCACTGAACGCTGCAGGGCAGGGAAGAAATAAATGGTCTCATAGTTTAATCCATTG
 161 ATAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaCAUCCGGAAAUCUAGUGAa 5'
            ||| |||    || |:|| 
Target 5' gcGTAAGCCCACTGAACGCTg 3'
 97 - 117 107.00 -8.30
2 
miRNA  3' uacauCCGGA-AAUCUAGugaa 5'
               |||||   ||:||    
Target 5' cctctGGCCTGAAAGGTCtgcc 3'
 28 - 49 80.00 -12.20
3 
miRNA  3' uacaUCCGGAA---A--UCUAGUgaa 5'
              |||||||   |  ||: ||   
Target 5' acacAGGCCTTCCCTGCAGGGCAgcc 3'
 52 - 77 75.00 -13.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26970470 7 COSMIC
COSN30106493 8 COSMIC
COSN15020634 15 COSMIC
COSN30468209 15 COSMIC
COSN31593638 17 COSMIC
COSN27107177 66 COSMIC
COSN17406984 93 COSMIC
COSN31596006 100 COSMIC
COSN31500087 101 COSMIC
COSN30506116 106 COSMIC
COSN31573543 130 COSMIC
COSN9849302 522 COSMIC
COSN9355037 603 COSMIC
COSN20723977 1112 COSMIC
COSN1766545 1317 COSMIC
COSN20979961 1386 COSMIC
COSN6142791 1424 COSMIC
COSN22425178 1707 COSMIC
COSN1214289 1747 COSMIC
COSN28895136 1868 COSMIC
COSN1766544 2134 COSMIC
COSN9849301 2761 COSMIC
COSN23751691 2809 COSMIC
COSN8259577 2934 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1411132150 3 dbSNP
rs757097133 4 dbSNP
rs199880123 7 dbSNP
rs763978785 8 dbSNP
rs762805067 12 dbSNP
rs1303919744 14 dbSNP
rs745439546 15 dbSNP
rs377001468 16 dbSNP
rs759191975 19 dbSNP
rs776078700 20 dbSNP
rs905516334 21 dbSNP
rs1482441009 24 dbSNP
rs770493510 26 dbSNP
rs532070824 31 dbSNP
rs1319226051 35 dbSNP
rs1289256370 38 dbSNP
rs1488138847 39 dbSNP
rs1191698444 43 dbSNP
rs1266358993 49 dbSNP
rs932411929 54 dbSNP
rs1427077692 59 dbSNP
rs1489187755 63 dbSNP
rs898208066 66 dbSNP
rs1037984252 67 dbSNP
rs1426532324 89 dbSNP
rs1263253819 90 dbSNP
rs559764233 91 dbSNP
rs1431205534 98 dbSNP
rs145640340 99 dbSNP
rs1348766457 105 dbSNP
rs1297320505 109 dbSNP
rs1311154733 113 dbSNP
rs1295813519 114 dbSNP
rs1360406449 116 dbSNP
rs1237742293 125 dbSNP
rs185168817 135 dbSNP
rs1326527877 137 dbSNP
rs895528489 142 dbSNP
rs939186806 144 dbSNP
rs1322392872 147 dbSNP
rs1223787484 148 dbSNP
rs1248389948 155 dbSNP
rs539347139 158 dbSNP
rs981301888 159 dbSNP
rs374849523 160 dbSNP
rs1454488386 166 dbSNP
rs1036932775 171 dbSNP
rs1248388791 172 dbSNP
rs1022332140 175 dbSNP
rs1365811483 176 dbSNP
rs1161281397 177 dbSNP
rs112767280 178 dbSNP
rs1439505868 180 dbSNP
rs956667498 180 dbSNP
rs2868196 183 dbSNP
rs943256453 183 dbSNP
rs2077201 184 dbSNP
rs1163191256 185 dbSNP
rs1367789358 185 dbSNP
rs879528551 185 dbSNP
rs954745519 187 dbSNP
rs1009116797 188 dbSNP
rs372397715 188 dbSNP
rs1196068235 189 dbSNP
rs777462289 190 dbSNP
rs1264638287 191 dbSNP
rs1268606444 191 dbSNP
rs1208776615 192 dbSNP
rs913962403 194 dbSNP
rs1287758171 195 dbSNP
rs1214123198 198 dbSNP
rs1183146067 200 dbSNP
rs1292829738 200 dbSNP
rs1472892594 200 dbSNP
rs71336972 200 dbSNP
rs1468571895 209 dbSNP
rs1333878099 218 dbSNP
rs551468954 225 dbSNP
rs1359990372 231 dbSNP
rs1352737614 234 dbSNP
rs1303985357 241 dbSNP
rs1235324910 242 dbSNP
rs1450442475 244 dbSNP
rs1029161353 246 dbSNP
rs988267004 247 dbSNP
rs997025489 255 dbSNP
rs1349950405 257 dbSNP
rs898239270 258 dbSNP
rs1288910708 259 dbSNP
rs1038058129 260 dbSNP
rs1198536636 262 dbSNP
rs1382884195 264 dbSNP
rs558794746 269 dbSNP
rs1211792655 273 dbSNP
rs886738372 294 dbSNP
rs1296605712 299 dbSNP
rs1230734109 305 dbSNP
rs539167942 326 dbSNP
rs1471985713 327 dbSNP
rs180690203 329 dbSNP
rs1414878622 338 dbSNP
rs939278759 352 dbSNP
rs1172413455 358 dbSNP
rs1426276246 359 dbSNP
rs1376447624 364 dbSNP
rs1002379645 366 dbSNP
rs969587575 377 dbSNP
rs1025245428 379 dbSNP
rs926471804 379 dbSNP
rs553436254 381 dbSNP
rs536611885 382 dbSNP
rs1377598145 385 dbSNP
rs568386642 389 dbSNP
rs1230932920 391 dbSNP
rs1197501166 397 dbSNP
rs895509531 405 dbSNP
rs1345437111 407 dbSNP
rs1220682367 408 dbSNP
rs1047936025 409 dbSNP
rs993295821 410 dbSNP
rs746641 413 dbSNP
rs946513887 421 dbSNP
rs915346196 422 dbSNP
rs943225196 440 dbSNP
rs567820338 443 dbSNP
rs910440161 444 dbSNP
rs1051713364 445 dbSNP
rs1202011801 454 dbSNP
rs988184679 455 dbSNP
rs11671966 457 dbSNP
rs1170605973 465 dbSNP
rs911889580 468 dbSNP
rs988169371 469 dbSNP
rs777499060 471 dbSNP
rs79874975 479 dbSNP
rs77976196 480 dbSNP
rs376396746 482 dbSNP
rs1438385544 495 dbSNP
rs969574821 496 dbSNP
rs1276465110 498 dbSNP
rs995030918 499 dbSNP
rs1399623374 506 dbSNP
rs1276241073 516 dbSNP
rs1013879123 517 dbSNP
rs963492790 530 dbSNP
rs959966890 533 dbSNP
rs1336525048 535 dbSNP
rs1025946141 538 dbSNP
rs35995416 542 dbSNP
rs576381543 544 dbSNP
rs1187118346 545 dbSNP
rs1016644433 554 dbSNP
rs1450395887 565 dbSNP
rs1190739136 566 dbSNP
rs190920792 576 dbSNP
rs886813307 577 dbSNP
rs898896524 586 dbSNP
rs1056113697 589 dbSNP
rs187342813 593 dbSNP
rs563370720 597 dbSNP
rs1391393710 602 dbSNP
rs781257847 603 dbSNP
rs117630116 607 dbSNP
rs1465633226 618 dbSNP
rs1045361632 628 dbSNP
rs753010231 629 dbSNP
rs1364191263 631 dbSNP
rs1435439567 643 dbSNP
rs1425148867 644 dbSNP
rs888972527 650 dbSNP
rs1338272708 652 dbSNP
rs533300718 658 dbSNP
rs1265489936 669 dbSNP
rs1359121971 674 dbSNP
rs766398935 675 dbSNP
rs1052555599 678 dbSNP
rs1237732092 683 dbSNP
rs1189308397 696 dbSNP
rs115760198 705 dbSNP
rs936671992 706 dbSNP
rs925347434 716 dbSNP
rs911906299 717 dbSNP
rs1423414804 719 dbSNP
rs1188395005 721 dbSNP
rs987477910 726 dbSNP
rs931948948 728 dbSNP
rs1387747809 731 dbSNP
rs181891385 736 dbSNP
rs974026715 738 dbSNP
rs386808721 739 dbSNP
rs561429892 741 dbSNP
rs1395056986 743 dbSNP
rs1256213264 745 dbSNP
rs55851701 746 dbSNP
rs536563145 747 dbSNP
rs1225977511 756 dbSNP
rs1330378140 760 dbSNP
rs982518480 761 dbSNP
rs951121167 762 dbSNP
rs565500778 767 dbSNP
rs1483071391 768 dbSNP
rs951623539 773 dbSNP
rs1258427320 775 dbSNP
rs764053952 777 dbSNP
rs1035153291 780 dbSNP
rs1003228697 785 dbSNP
rs142296375 786 dbSNP
rs963042211 787 dbSNP
rs1449638307 788 dbSNP
rs1398799759 789 dbSNP
rs1161066288 793 dbSNP
rs1375714433 798 dbSNP
rs1373987312 807 dbSNP
rs904817181 810 dbSNP
rs1328647780 818 dbSNP
rs190144010 822 dbSNP
rs765664282 824 dbSNP
rs893684277 829 dbSNP
rs573388717 835 dbSNP
rs1030128993 842 dbSNP
rs935432691 844 dbSNP
rs1230744930 848 dbSNP
rs1299727224 855 dbSNP
rs1311964114 860 dbSNP
rs890559972 864 dbSNP
rs1234351370 868 dbSNP
rs1471649915 872 dbSNP
rs1367672018 883 dbSNP
rs1257992065 890 dbSNP
rs1179082429 900 dbSNP
rs1459011437 904 dbSNP
rs1204582143 905 dbSNP
rs1252585045 909 dbSNP
rs573774619 910 dbSNP
rs1198034634 917 dbSNP
rs1265106006 917 dbSNP
rs932006054 937 dbSNP
rs1432389357 939 dbSNP
rs1468976648 961 dbSNP
rs536649815 962 dbSNP
rs1427399476 963 dbSNP
rs921917179 964 dbSNP
rs1226822393 980 dbSNP
rs777260989 981 dbSNP
rs892357225 987 dbSNP
rs1355987440 994 dbSNP
rs1292306736 995 dbSNP
rs1367439629 1007 dbSNP
rs764601958 1011 dbSNP
rs936639037 1014 dbSNP
rs1340350191 1016 dbSNP
rs531457567 1032 dbSNP
rs73041757 1040 dbSNP
rs1275512773 1042 dbSNP
rs376472164 1053 dbSNP
rs553979858 1067 dbSNP
rs1219376132 1074 dbSNP
rs1263642563 1075 dbSNP
rs908078120 1075 dbSNP
rs917997738 1075 dbSNP
rs1309195349 1077 dbSNP
rs1447356861 1080 dbSNP
rs1187527292 1086 dbSNP
rs557067656 1090 dbSNP
rs983596310 1097 dbSNP
rs1411165992 1104 dbSNP
rs112600495 1107 dbSNP
rs1349963842 1112 dbSNP
rs1458851054 1114 dbSNP
rs1328418716 1115 dbSNP
rs1363464952 1122 dbSNP
rs930150969 1127 dbSNP
rs1298628320 1128 dbSNP
rs1364289445 1130 dbSNP
rs1226714436 1131 dbSNP
rs1325027816 1136 dbSNP
rs569036248 1139 dbSNP
rs982234746 1140 dbSNP
rs969115951 1148 dbSNP
rs963012853 1149 dbSNP
rs1441337886 1151 dbSNP
rs1207815141 1153 dbSNP
rs1248280067 1155 dbSNP
rs112683198 1162 dbSNP
rs1179643274 1163 dbSNP
rs1177943467 1164 dbSNP
rs1478356018 1175 dbSNP
rs985764674 1180 dbSNP
rs1248517256 1181 dbSNP
rs139678953 1183 dbSNP
rs1451218906 1185 dbSNP
rs1287047033 1186 dbSNP
rs1219180379 1192 dbSNP
rs1324329815 1195 dbSNP
rs1351975012 1208 dbSNP
rs1030511606 1210 dbSNP
rs1387018577 1220 dbSNP
rs1235662346 1222 dbSNP
rs1370430549 1224 dbSNP
rs1321595281 1226 dbSNP
rs1276083677 1235 dbSNP
rs893715535 1242 dbSNP
rs1030895383 1247 dbSNP
rs1433716737 1249 dbSNP
rs999380375 1272 dbSNP
rs1283731486 1276 dbSNP
rs997329321 1278 dbSNP
rs1235141296 1287 dbSNP
rs566255724 1296 dbSNP
rs368028967 1297 dbSNP
rs546245095 1300 dbSNP
rs932053902 1313 dbSNP
rs529652883 1315 dbSNP
rs560981668 1321 dbSNP
rs903783103 1322 dbSNP
rs1045047959 1325 dbSNP
rs1483300292 1338 dbSNP
rs75533701 1339 dbSNP
rs747994863 1346 dbSNP
rs908151833 1352 dbSNP
rs1157891976 1354 dbSNP
rs1472534038 1354 dbSNP
rs1410602537 1356 dbSNP
rs1413047439 1358 dbSNP
rs1047927249 1360 dbSNP
rs1414951961 1361 dbSNP
rs896541118 1364 dbSNP
rs1427236758 1369 dbSNP
rs1056980565 1370 dbSNP
rs1392091268 1371 dbSNP
rs1306213292 1374 dbSNP
rs531268594 1386 dbSNP
rs1279995508 1387 dbSNP
rs758490467 1387 dbSNP
rs930140189 1387 dbSNP
rs1477751219 1389 dbSNP
rs938870937 1394 dbSNP
rs928788266 1396 dbSNP
rs1212452460 1397 dbSNP
rs918789410 1397 dbSNP
rs1248960973 1408 dbSNP
rs1483048922 1425 dbSNP
rs1183531569 1427 dbSNP
rs1264095215 1429 dbSNP
rs1038581034 1432 dbSNP
rs981923289 1440 dbSNP
rs565402453 1441 dbSNP
rs1426175427 1444 dbSNP
rs545636125 1456 dbSNP
rs1166842243 1462 dbSNP
rs1370009103 1468 dbSNP
rs1410444578 1468 dbSNP
rs985733584 1469 dbSNP
rs916278836 1480 dbSNP
rs989161069 1484 dbSNP
rs1434072909 1486 dbSNP
rs923030466 1488 dbSNP
rs1056636035 1491 dbSNP
rs956560937 1491 dbSNP
rs1271943211 1494 dbSNP
rs1340849441 1495 dbSNP
rs111468181 1497 dbSNP
rs1000703982 1503 dbSNP
rs1030927827 1506 dbSNP
rs73041755 1507 dbSNP
rs562524395 1508 dbSNP
rs186494215 1509 dbSNP
rs1012238117 1511 dbSNP
rs1389724993 1512 dbSNP
rs996303396 1518 dbSNP
rs1343680768 1530 dbSNP
rs1398600154 1534 dbSNP
rs1403514591 1544 dbSNP
rs777270638 1546 dbSNP
rs1056549532 1556 dbSNP
rs1442745797 1561 dbSNP
rs900595341 1575 dbSNP
rs754903342 1585 dbSNP
rs1363945374 1601 dbSNP
rs1338034835 1602 dbSNP
rs1006179751 1610 dbSNP
rs1354920203 1612 dbSNP
rs146373635 1617 dbSNP
rs1048000807 1619 dbSNP
rs1207165359 1622 dbSNP
rs1247680184 1623 dbSNP
rs1429307653 1624 dbSNP
rs941547987 1627 dbSNP
rs911444172 1631 dbSNP
rs202208156 1634 dbSNP
rs938930562 1637 dbSNP
rs931665603 1645 dbSNP
rs1395053709 1649 dbSNP
rs1159296338 1650 dbSNP
rs928843264 1653 dbSNP
rs1318249226 1659 dbSNP
rs1462836642 1659 dbSNP
rs1413909536 1660 dbSNP
rs535291926 1664 dbSNP
rs181328809 1665 dbSNP
rs948887191 1667 dbSNP
rs1338183788 1668 dbSNP
rs1364026762 1687 dbSNP
rs1243364509 1688 dbSNP
rs1476950304 1689 dbSNP
rs1262788696 1691 dbSNP
rs866820778 1694 dbSNP
rs142416938 1695 dbSNP
rs989192353 1696 dbSNP
rs957701832 1699 dbSNP
rs1267871184 1705 dbSNP
rs1486350024 1711 dbSNP
rs923597189 1711 dbSNP
rs79065831 1714 dbSNP
rs1254261210 1716 dbSNP
rs954773167 1733 dbSNP
rs1030217624 1735 dbSNP
rs1418524511 1737 dbSNP
rs1476128207 1739 dbSNP
rs996428877 1755 dbSNP
rs991182883 1757 dbSNP
rs1362993681 1759 dbSNP
rs960730869 1761 dbSNP
rs1319285845 1763 dbSNP
rs538453310 1771 dbSNP
rs1399554290 1774 dbSNP
rs11670695 1775 dbSNP
rs537196119 1777 dbSNP
rs1219982975 1779 dbSNP
rs375106557 1785 dbSNP
rs1315642205 1787 dbSNP
rs1006254783 1788 dbSNP
rs1357970125 1793 dbSNP
rs897219793 1812 dbSNP
rs886481391 1813 dbSNP
rs1047717540 1814 dbSNP
rs552742475 1824 dbSNP
rs1050004057 1827 dbSNP
rs1447181736 1829 dbSNP
rs1401005170 1830 dbSNP
rs1211735465 1833 dbSNP
rs934204817 1836 dbSNP
rs1486643807 1839 dbSNP
rs536394780 1847 dbSNP
rs1179916582 1864 dbSNP
rs901430338 1868 dbSNP
rs1040423027 1873 dbSNP
rs1003160093 1876 dbSNP
rs935025756 1879 dbSNP
rs923674010 1886 dbSNP
rs1464161073 1887 dbSNP
rs1423114201 1888 dbSNP
rs907455606 1889 dbSNP
rs758589896 1903 dbSNP
rs916450130 1910 dbSNP
rs750665427 1911 dbSNP
rs1412064638 1914 dbSNP
rs371206952 1917 dbSNP
rs893278082 1921 dbSNP
rs1181692701 1924 dbSNP
rs1393532063 1925 dbSNP
rs1458585699 1929 dbSNP
rs990675116 1931 dbSNP
rs1330791212 1937 dbSNP
rs550564516 1951 dbSNP
rs1034959509 1957 dbSNP
rs1340139034 1959 dbSNP
rs1204448099 1965 dbSNP
rs1053560023 1968 dbSNP
rs1250725380 1972 dbSNP
rs1199924669 1990 dbSNP
rs770834957 1991 dbSNP
rs936405591 1997 dbSNP
rs1264988130 2000 dbSNP
rs34035782 2002 dbSNP
rs1396450985 2003 dbSNP
rs757564234 2014 dbSNP
rs932963855 2017 dbSNP
rs1310281807 2023 dbSNP
rs1245023463 2024 dbSNP
rs1355665985 2035 dbSNP
rs1463957923 2037 dbSNP
rs1005628197 2038 dbSNP
rs1394197842 2039 dbSNP
rs1442007957 2044 dbSNP
rs1305912460 2069 dbSNP
rs1363244904 2072 dbSNP
rs77193470 2073 dbSNP
rs200252724 2086 dbSNP
rs117274342 2088 dbSNP
rs1016033625 2093 dbSNP
rs901393182 2094 dbSNP
rs566035594 2097 dbSNP
rs560034300 2104 dbSNP
rs1294254314 2105 dbSNP
rs934966966 2106 dbSNP
rs1459623060 2113 dbSNP
rs902221607 2116 dbSNP
rs1348401384 2119 dbSNP
rs1043486634 2130 dbSNP
rs950794824 2131 dbSNP
rs188562125 2133 dbSNP
rs1440725294 2134 dbSNP
rs1003286914 2136 dbSNP
rs907176083 2141 dbSNP
rs1023650768 2144 dbSNP
rs775914260 2145 dbSNP
rs1417697457 2152 dbSNP
rs1013152823 2153 dbSNP
rs893330381 2154 dbSNP
rs529424094 2155 dbSNP
rs934783885 2158 dbSNP
rs1430268588 2160 dbSNP
rs1289593101 2173 dbSNP
rs563598482 2176 dbSNP
rs902268641 2190 dbSNP
rs765885316 2191 dbSNP
rs762518144 2194 dbSNP
rs1274789852 2197 dbSNP
rs909853343 2213 dbSNP
rs1354156989 2214 dbSNP
rs1287979945 2217 dbSNP
rs1242267953 2220 dbSNP
rs1486568163 2223 dbSNP
rs1237853606 2225 dbSNP
rs1257485412 2246 dbSNP
rs984090257 2255 dbSNP
rs954105744 2263 dbSNP
rs1028420503 2273 dbSNP
rs370017033 2278 dbSNP
rs1302036969 2285 dbSNP
rs543821143 2287 dbSNP
rs965599323 2292 dbSNP
rs1302789815 2299 dbSNP
rs922950157 2308 dbSNP
rs1354794046 2312 dbSNP
rs1032338951 2313 dbSNP
rs1294971246 2324 dbSNP
rs999140531 2327 dbSNP
rs1222932933 2338 dbSNP
rs1284544921 2341 dbSNP
rs529168636 2355 dbSNP
rs1318303939 2361 dbSNP
rs975089539 2372 dbSNP
rs1256179745 2375 dbSNP
rs943287300 2404 dbSNP
rs1157287086 2410 dbSNP
rs1419603166 2415 dbSNP
rs1250175777 2429 dbSNP
rs1469969337 2433 dbSNP
rs1043371536 2434 dbSNP
rs1378757721 2443 dbSNP
rs1198903966 2444 dbSNP
rs1376138148 2452 dbSNP
rs183782886 2456 dbSNP
rs984595966 2461 dbSNP
rs772837977 2466 dbSNP
rs769380250 2467 dbSNP
rs1264747173 2476 dbSNP
rs1279900909 2477 dbSNP
rs981519030 2488 dbSNP
rs558440951 2490 dbSNP
rs971831006 2491 dbSNP
rs1022944750 2492 dbSNP
rs927856813 2494 dbSNP
rs1212344479 2496 dbSNP
rs1271544977 2503 dbSNP
rs1214234063 2513 dbSNP
rs1437728427 2526 dbSNP
rs376009179 2528 dbSNP
rs893402589 2552 dbSNP
rs1256543733 2555 dbSNP
rs939902950 2556 dbSNP
rs148788780 2560 dbSNP
rs999043935 2561 dbSNP
rs903322886 2569 dbSNP
rs954102932 2574 dbSNP
rs1394294427 2582 dbSNP
rs921332909 2589 dbSNP
rs1042560283 2605 dbSNP
rs1400820403 2606 dbSNP
rs1438373846 2610 dbSNP
rs1342664072 2611 dbSNP
rs976904536 2612 dbSNP
rs1235909409 2621 dbSNP
rs997257707 2627 dbSNP
rs144396401 2630 dbSNP
rs1339371408 2644 dbSNP
rs1038688992 2648 dbSNP
rs943004316 2649 dbSNP
rs909135458 2651 dbSNP
rs968933301 2652 dbSNP
rs1253898866 2656 dbSNP
rs1469964784 2660 dbSNP
rs1021895561 2665 dbSNP
rs1010562660 2683 dbSNP
rs1372576507 2684 dbSNP
rs894834277 2691 dbSNP
rs1003326968 2702 dbSNP
rs906278851 2707 dbSNP
rs1048941210 2712 dbSNP
rs552781373 2714 dbSNP
rs1442628677 2718 dbSNP
rs919082612 2723 dbSNP
rs1227448178 2730 dbSNP
rs1316387636 2734 dbSNP
rs909790923 2734 dbSNP
rs1333274054 2738 dbSNP
rs981954755 2762 dbSNP
rs1048324840 2765 dbSNP
rs932643228 2767 dbSNP
rs1337312130 2769 dbSNP
rs1203621484 2796 dbSNP
rs1261235082 2798 dbSNP
rs971501642 2799 dbSNP
rs1191182277 2800 dbSNP
rs1447682185 2811 dbSNP
rs915949557 2828 dbSNP
rs991492824 2833 dbSNP
rs1265298026 2834 dbSNP
rs11666472 2835 dbSNP
rs543639437 2847 dbSNP
rs111740430 2848 dbSNP
rs999096215 2849 dbSNP
rs1156458983 2850 dbSNP
rs1383728854 2854 dbSNP
rs1482267713 2861 dbSNP
rs977554777 2865 dbSNP
rs556732674 2868 dbSNP
rs537059813 2876 dbSNP
rs1354166037 2877 dbSNP
rs113211034 2896 dbSNP
rs746933477 2897 dbSNP
rs1021866174 2905 dbSNP
rs1357777636 2907 dbSNP
rs1237279072 2923 dbSNP
rs997707852 2935 dbSNP
rs771238725 2937 dbSNP
rs1276568600 2938 dbSNP
rs1351636007 2939 dbSNP
rs1227076638 2940 dbSNP
rs1341443609 2941 dbSNP
rs1134575 2954 dbSNP
rs1207024485 2965 dbSNP
rs901600473 2969 dbSNP
rs149550516 2970 dbSNP
rs551392047 2972 dbSNP
rs752720766 2975 dbSNP
rs887413260 2992 dbSNP
rs1048993900 2995 dbSNP
rs929218623 3006 dbSNP
rs765117730 3014 dbSNP
rs1179341192 3044 dbSNP
rs1362900249 3045 dbSNP
rs1003639840 3062 dbSNP
rs1406045449 3069 dbSNP
rs919120968 3076 dbSNP
rs1015326480 3078 dbSNP
rs369186922 3089 dbSNP
rs1390068827 3095 dbSNP
rs1306710257 3097 dbSNP
rs1465712889 3104 dbSNP
rs1336637810 3108 dbSNP
rs1241448323 3110 dbSNP
rs949886101 3114 dbSNP
rs916017785 3115 dbSNP
rs779922005 3121 dbSNP
rs1211625319 3134 dbSNP
rs528820748 3137 dbSNP
rs138342316 3141 dbSNP
rs1193904674 3147 dbSNP
rs1368812383 3158 dbSNP
rs745881224 3159 dbSNP
rs571962902 3160 dbSNP
rs565404224 3172 dbSNP
rs925926286 3174 dbSNP
rs553714723 3179 dbSNP
rs563687561 3195 dbSNP
rs1361460075 3198 dbSNP
rs1460907274 3199 dbSNP
rs1298034015 3203 dbSNP
rs1421950740 3214 dbSNP
rs74798671 3217 dbSNP
rs1393441172 3224 dbSNP
rs541389211 3235 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 84902.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uacaUCCGGAAAUCUAGUGAa 5'
              |||:    :||||||| 
Target 5' ----AGGUGGGAGGAUCACUu 3'
 		1 - 17
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000305768.5 | 3UTR | AGGUGGGAGGAUCACUUGAGCCUGGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.416 0.18 0.143 0.38 7 Click to see details
BLCA -0.83 0.19 -0.500 0.33 3 Click to see details
BRCA 0.822 0.19 0.500 0.33 3 Click to see details
UCEC -0.688 0.26 -0.500 0.33 3 Click to see details
UCEC -0.688 0.26 -0.500 0.33 3 Click to see details
UCEC -0.688 0.26 -0.500 0.33 3 Click to see details
UCEC -0.688 0.26 -0.500 0.33 3 Click to see details
UCEC -0.688 0.26 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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