pre-miRNA Information | |
---|---|
pre-miRNA | hsa-mir-873 |
Genomic Coordinates | chr9: 28888879 - 28888955 |
Synonyms | MIRN873, hsa-mir-873, MIR873 |
Description | Homo sapiens miR-873 stem-loop |
Comment | This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques . |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mature miRNA | hsa-miR-873-3p | |||||||||||||||||||||
Sequence | 46| GGAGACUGAUGAGUUCCCGGGA |67 | |||||||||||||||||||||
Evidence | Not_experimental | |||||||||||||||||||||
Experiments | ||||||||||||||||||||||
SNPs in miRNA |
|
|||||||||||||||||||||
Putative Targets |
miRNA Expression profile | |
---|---|
Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
|
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene Symbol | F2RL2 | ||||||||||||||||||||
Synonyms | PAR-3, PAR3 | ||||||||||||||||||||
Description | coagulation factor II thrombin receptor like 2 | ||||||||||||||||||||
Transcript | NM_004101 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on F2RL2 | |||||||||||||||||||||
3'UTR of F2RL2 (miRNA target sites are highlighted) |
>F2RL2|NM_004101|3'UTR 1 TGAAATGATCTTAGAGAACAAGGACAGCCATCACAGAGAACGTCTGTTTTCAAGAACAACATAAGCATAGTGCAAGGAGC 81 TCCATTTCCGAGCTCCTAAGAAATATGCTTCAAAGGTCAAACATTACAAAAGCATTAGTAGTTTGTTTGTTTGTTTTTGA 161 GACTGAGTCTCACTTTATCACCCAGACTGGCGTGCAGTGGCACTATCTTGGCTCATTGCAACCTCTGCCTCCCAGGTCAG 241 CCTCCCAAGTAGCTGGGATTACACCACCATGCCCAGCTACTAAAAATACTTGTATTTTTAGTAGAGACGGGGTTTCACCA 321 TGTTGACCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTTCCGGCCTCAGCCTCCCAAAGTGCTGGATTACAGGCGT 401 GAGCCACTGAGCCAGCCAGCATTAGTAATTTTTAAAAACACTTTATCAGTATTTTAAAAATGTTAATGCAGGAGAAAAGA 481 TATCACAACTCTATGGAAAATGACATTTCCATTTGCCTTATTGCTACTTCAAGCTCTTTAAATCACCATCTTCCCTATTT 561 CTGTGAGTGGTATTGCCATCCTTGACATTTGACATCATTTTTTATTCTTTGGTCTCTTTTGACTCTCATGCTGGTGGCTG 641 CCTCATCAACTGATTCTATCTTTGTAGGGTCCCTCACCAGGGTCTTTTATCTAGTTTCACCTTTGCCTTCTTTTTTCCTT 721 TTTTTAATAGAGACAGTGTCTCGCTTCGTCACCTGGCTGAAGTGCAGTAGCCTGATCATAGCTCACTTCAGCCTCCAACT 801 CCTGGGCTCAAGCAATCCTGCTGTCTCAGCCTCCCAAGTAACTAAGACTACAGGCATGCACCACCATACCCAACTAATTT 881 TATTTTTTATTTTTTGCAGAGATGGAGTCTCACTGTTGCCCAGGCTGGTCTTGAACTCCTGGTCTCGAGTGATCTTCCTA 961 TCTCAGCCTCCCAAAGTGCTGGGACTACAGGCATGAGCCACTACGTCCAGGCCACCTCTACCTTCTAACCATTCTCTCCA 1041 CTGCCAGCCTACCCTCCACCACTTCACAAGTCCTGCCAGATTAATCTTCCTTAGATATCAGTTAGGATACATCACTAAAA 1121 CATTTCCACTAACTCCACTGTTTCTATAATAAATCATAAATCTTTAGCCTGGCATTCAAGGCTAACTTGCTAATCACACT 1201 TCCCATTAAACCTTGCTTATGATATAGGCACCAACCAAACCTCTTGCTCTGCTATATCTCCACTCTGCCTCAGACTGAAA 1281 AGCTAGTCCTAACGTCTTTGCCTTAATTCTGTTCATTTTTTCAAGTCCTTGAAGGACCATTCTTCCCTGATTCTCAGGCT 1361 AGAAGTGTCACTTTTCTTATCTGTACTTCCAAAGCACTTTCGTATATTTTTATTATGGCATTTATATATAGTTCATTTAT 1441 ATTTAAATTTTAATTCCATGAACAATCAAGTACCAAGTATAATGGAGAAGGTGCTCATCCTCTGCCTTCCTTGAGCTTCT 1521 GGGTGATGCCAGGCCCAAGTCTTTGTGGCACCCAGCTCCATGCTTTGAATACTATGTGGCTGAATGAATTTTTAAAATCT 1601 CAAAGCAGTTAAACAGCAGGAAAGCCCATTAACTTCGTACTGAAAAAGCAACATACTGTGATGATACGGGATGACATCAT 1681 TTCAGGTTGGGCATACAAAAAAGTAAGGAAGCTAAACTAAGACTATACTCACCAGGCCATTTAGAAGTTTTAAATAATGC 1761 CTCCACTATTTTTTTTCTTAGACATAGCTTTTAATGGGGAAATGGAATTTTGTTATTAATACCCATTATATTCCTGTAAG 1841 TAAATGACTATTTTTCCCTTAACTCAGTGATTAGACAGGAAGGAAGACATTAGTGATTAGACAGGAGGGAAGATATTAGT 1921 GATTAGACAGCAGGGAAGATATTAGTGGTAAAGAGTGAATGATAGTAGTGAATATAAATGGGGCTGAGGAAACTTTAAGC 2001 ATAAAAGATTCCTGAGATGACTTTACAAGTCTGTACGAATCTGCCTTGACTGTATATTTCATACTGCCCAACAAAACAAT 2081 AAAAAACAATTTTAAATGCAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
||||||||||||||||||||
miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
---|---|---|---|---|---|---|---|
miRNA:Target | ---- | ||||||
Validation Method |
|
||||||
Conditions | HEK293 | ||||||
Disease | 2151.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
||||||
miRNA-target interactions (Provided by authors) |
|
||||||
Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
|
CLIP-seq Support 1 for dataset GSM714647 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / mildMNase, repB |
Location of target site | ENST00000296641.4 | 3UTR | AGUCUCACUGUUGCCCAGGCUGGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
---|---|---|---|---|---|---|---|
|
MiRNA-Target Expression Profile (TCGA) | |||||||
---|---|---|---|---|---|---|---|
|
108 hsa-miR-873-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
![]() |
![]() |
|||||||
Strong evidence | Less strong evidence | |||||||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|||||
MIRT081178 | MIDN | midnolin | ![]() |
![]() |
2 | 4 | ||||||
MIRT109809 | ZFX | zinc finger protein, X-linked | ![]() |
![]() |
2 | 4 | ||||||
MIRT242383 | TMC5 | transmembrane channel like 5 | ![]() |
![]() |
2 | 4 | ||||||
MIRT444003 | METRN | meteorin, glial cell differentiation regulator | ![]() |
![]() |
2 | 4 | ||||||
MIRT444097 | SEPHS1 | selenophosphate synthetase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT446158 | RPL12 | ribosomal protein L12 | ![]() |
![]() |
2 | 2 | ||||||
MIRT446859 | SAMD9L | sterile alpha motif domain containing 9 like | ![]() |
![]() |
2 | 2 | ||||||
MIRT447275 | FZD5 | frizzled class receptor 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT447391 | TMPRSS15 | transmembrane protease, serine 15 | ![]() |
![]() |
2 | 2 | ||||||
MIRT448817 | FKBP1A | FK506 binding protein 1A | ![]() |
![]() |
2 | 4 | ||||||
MIRT450582 | HIST1H2BG | histone cluster 1 H2B family member g | ![]() |
![]() |
2 | 2 | ||||||
MIRT451776 | USP36 | ubiquitin specific peptidase 36 | ![]() |
![]() |
2 | 2 | ||||||
MIRT457961 | ABCC5 | ATP binding cassette subfamily C member 5 | ![]() |
![]() |
2 | 4 | ||||||
MIRT458424 | KLHL38 | kelch like family member 38 | ![]() |
![]() |
2 | 4 | ||||||
MIRT461383 | SLFN12L | schlafen family member 12 like | ![]() |
![]() |
2 | 2 | ||||||
MIRT467793 | SLC2A14 | solute carrier family 2 member 14 | ![]() |
![]() |
2 | 2 | ||||||
MIRT476517 | GABRB1 | gamma-aminobutyric acid type A receptor beta1 subunit | ![]() |
![]() |
2 | 2 | ||||||
MIRT480290 | C7orf73 | short transmembrane mitochondrial protein 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT482745 | HES7 | hes family bHLH transcription factor 7 | ![]() |
![]() |
2 | 10 | ||||||
MIRT483189 | HIST1H2AH | histone cluster 1 H2A family member h | ![]() |
![]() |
2 | 6 | ||||||
MIRT486545 | DCTN4 | dynactin subunit 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT486581 | ZNF619 | zinc finger protein 619 | ![]() |
![]() |
2 | 2 | ||||||
MIRT492604 | POLR3E | RNA polymerase III subunit E | ![]() |
![]() |
2 | 2 | ||||||
MIRT494130 | DCAF7 | DDB1 and CUL4 associated factor 7 | ![]() |
![]() |
2 | 6 | ||||||
MIRT496023 | ZBED3 | zinc finger BED-type containing 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT497121 | NBEAL1 | neurobeachin like 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT497400 | TMEM245 | transmembrane protein 245 | ![]() |
![]() |
2 | 2 | ||||||
MIRT501410 | RANBP10 | RAN binding protein 10 | ![]() |
![]() |
2 | 2 | ||||||
MIRT510947 | PPTC7 | PTC7 protein phosphatase homolog | ![]() |
![]() |
2 | 6 | ||||||
MIRT512494 | ARID2 | AT-rich interaction domain 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT512595 | ZNF783 | zinc finger family member 783 | ![]() |
![]() |
2 | 2 | ||||||
MIRT512612 | CNTN4 | contactin 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT517808 | UGDH | UDP-glucose 6-dehydrogenase | ![]() |
![]() |
2 | 6 | ||||||
MIRT520686 | TMED7 | transmembrane p24 trafficking protein 7 | ![]() |
![]() |
2 | 4 | ||||||
MIRT526179 | HEPH | hephaestin | ![]() |
![]() |
2 | 2 | ||||||
MIRT532568 | CSTF1 | cleavage stimulation factor subunit 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT533979 | TADA2A | transcriptional adaptor 2A | ![]() |
![]() |
2 | 2 | ||||||
MIRT538622 | CCSER2 | coiled-coil serine rich protein 2 | ![]() |
![]() |
2 | 4 | ||||||
MIRT539703 | EIF3H | eukaryotic translation initiation factor 3 subunit H | ![]() |
![]() |
2 | 2 | ||||||
MIRT539806 | GAPVD1 | GTPase activating protein and VPS9 domains 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT540422 | FAM83F | family with sequence similarity 83 member F | ![]() |
![]() |
2 | 2 | ||||||
MIRT540506 | CXCL10 | C-X-C motif chemokine ligand 10 | ![]() |
![]() |
2 | 2 | ||||||
MIRT540619 | F2RL2 | coagulation factor II thrombin receptor like 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT542423 | ZNF331 | zinc finger protein 331 | ![]() |
![]() |
2 | 2 | ||||||
MIRT542454 | AKR7A2 | aldo-keto reductase family 7 member A2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT543383 | CC2D2A | coiled-coil and C2 domain containing 2A | ![]() |
![]() |
2 | 2 | ||||||
MIRT544777 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | ![]() |
![]() |
2 | 4 | ||||||
MIRT544923 | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit | ![]() |
![]() |
2 | 2 | ||||||
MIRT549768 | ZNF611 | zinc finger protein 611 | ![]() |
![]() |
2 | 4 | ||||||
MIRT551242 | COLEC10 | collectin subfamily member 10 | ![]() |
![]() |
2 | 2 | ||||||
MIRT560474 | ENSA | endosulfine alpha | ![]() |
![]() |
2 | 2 | ||||||
MIRT569738 | GPR173 | G protein-coupled receptor 173 | ![]() |
![]() |
2 | 2 | ||||||
MIRT571297 | CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT572345 | CKAP2L | cytoskeleton associated protein 2 like | ![]() |
![]() |
2 | 2 | ||||||
MIRT573112 | ERBB2IP | erbb2 interacting protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT607744 | ANGPT4 | angiopoietin 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT607903 | SPRYD4 | SPRY domain containing 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT611744 | SERPING1 | serpin family G member 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT615101 | BNC2 | basonuclin 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT619124 | CD40LG | CD40 ligand | ![]() |
![]() |
2 | 2 | ||||||
MIRT625572 | ANKRD42 | ankyrin repeat domain 42 | ![]() |
![]() |
2 | 2 | ||||||
MIRT629038 | KLLN | killin, p53-regulated DNA replication inhibitor | ![]() |
![]() |
2 | 2 | ||||||
MIRT633986 | SLC35E2 | solute carrier family 35 member E2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT635675 | COX18 | COX18, cytochrome c oxidase assembly factor | ![]() |
![]() |
2 | 4 | ||||||
MIRT637471 | DEFB105B | defensin beta 105B | ![]() |
![]() |
2 | 4 | ||||||
MIRT637503 | DEFB105A | defensin beta 105A | ![]() |
![]() |
2 | 4 | ||||||
MIRT639735 | MAP2K2 | mitogen-activated protein kinase kinase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT640730 | C9orf64 | chromosome 9 open reading frame 64 | ![]() |
![]() |
2 | 2 | ||||||
MIRT645364 | C9orf47 | chromosome 9 open reading frame 47 | ![]() |
![]() |
2 | 2 | ||||||
MIRT647938 | RNF152 | ring finger protein 152 | ![]() |
![]() |
2 | 2 | ||||||
MIRT649400 | SH2D4A | SH2 domain containing 4A | ![]() |
![]() |
2 | 2 | ||||||
MIRT656860 | KIN | Kin17 DNA and RNA binding protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT663470 | POFUT2 | protein O-fucosyltransferase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT663507 | NKAPL | NFKB activating protein like | ![]() |
![]() |
2 | 4 | ||||||
MIRT667690 | KNSTRN | kinetochore localized astrin/SPAG5 binding protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT677403 | PCNP | PEST proteolytic signal containing nuclear protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT678682 | SCUBE3 | signal peptide, CUB domain and EGF like domain containing 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT678789 | NUPL2 | nucleoporin like 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT680649 | KIAA1456 | KIAA1456 | ![]() |
![]() |
2 | 2 | ||||||
MIRT682450 | MTX3 | metaxin 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT682740 | CA6 | carbonic anhydrase 6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT684421 | TUFT1 | tuftelin 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT690535 | TRAPPC2 | trafficking protein particle complex 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT690595 | C17orf105 | chromosome 17 open reading frame 105 | ![]() |
![]() |
2 | 2 | ||||||
MIRT690771 | PLA2G2C | phospholipase A2 group IIC | ![]() |
![]() |
2 | 2 | ||||||
MIRT692233 | ALDH1B1 | aldehyde dehydrogenase 1 family member B1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT693667 | MXRA7 | matrix remodeling associated 7 | ![]() |
![]() |
2 | 2 | ||||||
MIRT695551 | CLPB | ClpB homolog, mitochondrial AAA ATPase chaperonin | ![]() |
![]() |
2 | 2 | ||||||
MIRT695870 | C19orf52 | translocase of inner mitochondrial membrane 29 | ![]() |
![]() |
2 | 2 | ||||||
MIRT696214 | LYZ | lysozyme | ![]() |
![]() |
2 | 2 | ||||||
MIRT698368 | TMED4 | transmembrane p24 trafficking protein 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT700795 | PHTF2 | putative homeodomain transcription factor 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT701640 | MYLK3 | myosin light chain kinase 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT702989 | HERPUD2 | HERPUD family member 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT703627 | FBXL3 | F-box and leucine rich repeat protein 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT703783 | FAM102B | family with sequence similarity 102 member B | ![]() |
![]() |
2 | 2 | ||||||
MIRT704293 | DDX19B | DEAD-box helicase 19B | ![]() |
![]() |
2 | 2 | ||||||
MIRT704828 | CDC73 | cell division cycle 73 | ![]() |
![]() |
2 | 2 | ||||||
MIRT705014 | CAMK2N1 | calcium/calmodulin dependent protein kinase II inhibitor 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT708480 | OLR1 | oxidized low density lipoprotein receptor 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT710770 | PHF7 | PHD finger protein 7 | ![]() |
![]() |
2 | 2 | ||||||
MIRT718918 | TRIM66 | tripartite motif containing 66 | ![]() |
![]() |
2 | 2 | ||||||
MIRT720390 | ZNF549 | zinc finger protein 549 | ![]() |
![]() |
2 | 2 | ||||||
MIRT720593 | TTC39C | tetratricopeptide repeat domain 39C | ![]() |
![]() |
2 | 2 | ||||||
MIRT723515 | SIGLEC8 | sialic acid binding Ig like lectin 8 | ![]() |
![]() |
2 | 2 | ||||||
MIRT724458 | PRKX | protein kinase, X-linked | ![]() |
![]() |
2 | 2 | ||||||
MIRT737267 | UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | ![]() |
![]() |
![]() |
3 | 0 | |||||
MIRT737356 | ZIC2 | Zic family member 2 | ![]() |
![]() |
![]() |
![]() |
4 | 0 |
miRNA-Drug Associations | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|