pre-miRNA Information
pre-miRNA hsa-mir-873   
Genomic Coordinates chr9: 28888879 - 28888955
Synonyms MIRN873, hsa-mir-873, MIR873
Description Homo sapiens miR-873 stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-873-3p
Sequence 46| GGAGACUGAUGAGUUCCCGGGA |67
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760528397 3 dbSNP
rs773403294 9 dbSNP
rs1273846238 13 dbSNP
rs1339396073 15 dbSNP
rs1247999695 18 dbSNP
rs377380148 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol F2RL2   
Synonyms PAR-3, PAR3
Description coagulation factor II thrombin receptor like 2
Transcript NM_004101   
Expression
Putative miRNA Targets on F2RL2
3'UTR of F2RL2
(miRNA target sites are highlighted)
>F2RL2|NM_004101|3'UTR
   1 TGAAATGATCTTAGAGAACAAGGACAGCCATCACAGAGAACGTCTGTTTTCAAGAACAACATAAGCATAGTGCAAGGAGC
  81 TCCATTTCCGAGCTCCTAAGAAATATGCTTCAAAGGTCAAACATTACAAAAGCATTAGTAGTTTGTTTGTTTGTTTTTGA
 161 GACTGAGTCTCACTTTATCACCCAGACTGGCGTGCAGTGGCACTATCTTGGCTCATTGCAACCTCTGCCTCCCAGGTCAG
 241 CCTCCCAAGTAGCTGGGATTACACCACCATGCCCAGCTACTAAAAATACTTGTATTTTTAGTAGAGACGGGGTTTCACCA
 321 TGTTGACCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTTCCGGCCTCAGCCTCCCAAAGTGCTGGATTACAGGCGT
 401 GAGCCACTGAGCCAGCCAGCATTAGTAATTTTTAAAAACACTTTATCAGTATTTTAAAAATGTTAATGCAGGAGAAAAGA
 481 TATCACAACTCTATGGAAAATGACATTTCCATTTGCCTTATTGCTACTTCAAGCTCTTTAAATCACCATCTTCCCTATTT
 561 CTGTGAGTGGTATTGCCATCCTTGACATTTGACATCATTTTTTATTCTTTGGTCTCTTTTGACTCTCATGCTGGTGGCTG
 641 CCTCATCAACTGATTCTATCTTTGTAGGGTCCCTCACCAGGGTCTTTTATCTAGTTTCACCTTTGCCTTCTTTTTTCCTT
 721 TTTTTAATAGAGACAGTGTCTCGCTTCGTCACCTGGCTGAAGTGCAGTAGCCTGATCATAGCTCACTTCAGCCTCCAACT
 801 CCTGGGCTCAAGCAATCCTGCTGTCTCAGCCTCCCAAGTAACTAAGACTACAGGCATGCACCACCATACCCAACTAATTT
 881 TATTTTTTATTTTTTGCAGAGATGGAGTCTCACTGTTGCCCAGGCTGGTCTTGAACTCCTGGTCTCGAGTGATCTTCCTA
 961 TCTCAGCCTCCCAAAGTGCTGGGACTACAGGCATGAGCCACTACGTCCAGGCCACCTCTACCTTCTAACCATTCTCTCCA
1041 CTGCCAGCCTACCCTCCACCACTTCACAAGTCCTGCCAGATTAATCTTCCTTAGATATCAGTTAGGATACATCACTAAAA
1121 CATTTCCACTAACTCCACTGTTTCTATAATAAATCATAAATCTTTAGCCTGGCATTCAAGGCTAACTTGCTAATCACACT
1201 TCCCATTAAACCTTGCTTATGATATAGGCACCAACCAAACCTCTTGCTCTGCTATATCTCCACTCTGCCTCAGACTGAAA
1281 AGCTAGTCCTAACGTCTTTGCCTTAATTCTGTTCATTTTTTCAAGTCCTTGAAGGACCATTCTTCCCTGATTCTCAGGCT
1361 AGAAGTGTCACTTTTCTTATCTGTACTTCCAAAGCACTTTCGTATATTTTTATTATGGCATTTATATATAGTTCATTTAT
1441 ATTTAAATTTTAATTCCATGAACAATCAAGTACCAAGTATAATGGAGAAGGTGCTCATCCTCTGCCTTCCTTGAGCTTCT
1521 GGGTGATGCCAGGCCCAAGTCTTTGTGGCACCCAGCTCCATGCTTTGAATACTATGTGGCTGAATGAATTTTTAAAATCT
1601 CAAAGCAGTTAAACAGCAGGAAAGCCCATTAACTTCGTACTGAAAAAGCAACATACTGTGATGATACGGGATGACATCAT
1681 TTCAGGTTGGGCATACAAAAAAGTAAGGAAGCTAAACTAAGACTATACTCACCAGGCCATTTAGAAGTTTTAAATAATGC
1761 CTCCACTATTTTTTTTCTTAGACATAGCTTTTAATGGGGAAATGGAATTTTGTTATTAATACCCATTATATTCCTGTAAG
1841 TAAATGACTATTTTTCCCTTAACTCAGTGATTAGACAGGAAGGAAGACATTAGTGATTAGACAGGAGGGAAGATATTAGT
1921 GATTAGACAGCAGGGAAGATATTAGTGGTAAAGAGTGAATGATAGTAGTGAATATAAATGGGGCTGAGGAAACTTTAAGC
2001 ATAAAAGATTCCTGAGATGACTTTACAAGTCTGTACGAATCTGCCTTGACTGTATATTTCATACTGCCCAACAAAACAAT
2081 AAAAAACAATTTTAAATGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agggcccUUGAGU--AGUCAGAGg 5'
                 |:||||  |||| ||| 
Target 5' tgatcatAGCTCACTTCAGCCTCc 3'
773 - 796 129.00 -15.40
2
miRNA  3' agGGCC----CUUGAGUAGUCAGAGg 5'
            |:||    ||||||  ::||||| 
Target 5' ggCTGGTCTTGAACTC-CTGGTCTCg 3'
923 - 947 129.00 -17.20
3
miRNA  3' agggcccuUGAGUAGUCAGAGg 5'
                  |:|| |::||||| 
Target 5' cattttttATTCTTTGGTCTCt 3'
596 - 617 126.00 -10.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30452372 32 COSMIC
COSN31573840 38 COSMIC
COSN30543319 41 COSMIC
COSN30169698 59 COSMIC
COSN30122422 68 COSMIC
COSN30484854 77 COSMIC
COSN30163600 88 COSMIC
COSN14762636 102 COSMIC
COSN31593612 138 COSMIC
COSN31778397 516 COSMIC
COSN26567811 1006 COSMIC
COSN30542054 1198 COSMIC
COSN26688053 1402 COSMIC
COSN27360536 1463 COSMIC
COSN26507507 1493 COSMIC
COSN25765124 1505 COSMIC
COSN30538915 1509 COSMIC
COSN32065281 1636 COSMIC
COSN31587947 1667 COSMIC
COSN31482524 1670 COSMIC
COSN28696273 1692 COSMIC
COSN2117699 1750 COSMIC
COSN20101383 1810 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1244654724 3 dbSNP
rs2069684 6 dbSNP
rs1241043038 10 dbSNP
rs763773916 19 dbSNP
rs762756940 23 dbSNP
rs1283817742 27 dbSNP
rs1222175128 30 dbSNP
rs775317252 32 dbSNP
rs1411038367 33 dbSNP
rs1315766767 34 dbSNP
rs777253204 35 dbSNP
rs2069701 41 dbSNP
rs200098123 42 dbSNP
rs1431917632 43 dbSNP
rs769307910 46 dbSNP
rs1181294111 51 dbSNP
rs1317158672 51 dbSNP
rs572690258 57 dbSNP
rs958682642 64 dbSNP
rs1406474940 65 dbSNP
rs1343573955 67 dbSNP
rs1034676876 68 dbSNP
rs1002234443 69 dbSNP
rs1447584692 77 dbSNP
rs1282590043 78 dbSNP
rs1258272489 85 dbSNP
rs968441631 89 dbSNP
rs1022276477 90 dbSNP
rs1009674089 97 dbSNP
rs1234118607 98 dbSNP
rs2069685 102 dbSNP
rs2069702 106 dbSNP
rs1209015356 109 dbSNP
rs190180917 116 dbSNP
rs1182267834 124 dbSNP
rs1411231068 131 dbSNP
rs1411922939 132 dbSNP
rs2069686 135 dbSNP
rs1040345188 139 dbSNP
rs1425633089 142 dbSNP
rs1308416175 150 dbSNP
rs1332484827 153 dbSNP
rs372139148 154 dbSNP
rs1413932615 157 dbSNP
rs1400047555 159 dbSNP
rs757460096 162 dbSNP
rs1174221794 165 dbSNP
rs1356486659 167 dbSNP
rs759254142 182 dbSNP
rs551078614 191 dbSNP
rs1046672204 192 dbSNP
rs1348638938 203 dbSNP
rs1407330875 205 dbSNP
rs368607249 216 dbSNP
rs567479800 219 dbSNP
rs929735134 220 dbSNP
rs1344811894 221 dbSNP
rs1217803430 223 dbSNP
rs1276153310 225 dbSNP
rs1473373181 227 dbSNP
rs947790955 235 dbSNP
rs550301042 238 dbSNP
rs916989729 242 dbSNP
rs530516675 250 dbSNP
rs1205359798 267 dbSNP
rs1252089192 272 dbSNP
rs1187751434 280 dbSNP
rs1441028319 286 dbSNP
rs1250433642 294 dbSNP
rs992713069 298 dbSNP
rs1201559831 302 dbSNP
rs1247179150 303 dbSNP
rs753600254 308 dbSNP
rs927262691 309 dbSNP
rs979101098 312 dbSNP
rs1168153575 319 dbSNP
rs1368816262 321 dbSNP
rs989244760 327 dbSNP
rs1324829807 329 dbSNP
rs968600230 330 dbSNP
rs766140776 345 dbSNP
rs570072931 348 dbSNP
rs1022308877 354 dbSNP
rs1350525410 365 dbSNP
rs1266328383 366 dbSNP
rs1339498699 371 dbSNP
rs1224061122 373 dbSNP
rs1290575020 374 dbSNP
rs186008904 378 dbSNP
rs956812462 384 dbSNP
rs1196572408 399 dbSNP
rs181385728 404 dbSNP
rs998390675 412 dbSNP
rs2069687 415 dbSNP
rs1447078916 422 dbSNP
rs188551970 424 dbSNP
rs1426699892 425 dbSNP
rs760829267 433 dbSNP
rs772808862 441 dbSNP
rs1390035650 443 dbSNP
rs1404105270 455 dbSNP
rs2069703 467 dbSNP
rs888663492 469 dbSNP
rs1046748816 470 dbSNP
rs1318034262 471 dbSNP
rs573925844 478 dbSNP
rs1296497132 480 dbSNP
rs1458346023 481 dbSNP
rs929641843 488 dbSNP
rs895592683 489 dbSNP
rs1057270896 490 dbSNP
rs1246456128 491 dbSNP
rs1284279394 494 dbSNP
rs1027667151 496 dbSNP
rs1208012193 502 dbSNP
rs937077994 507 dbSNP
rs1471584415 515 dbSNP
rs994899810 516 dbSNP
rs897644207 521 dbSNP
rs927139463 544 dbSNP
rs1246486160 546 dbSNP
rs1446689354 547 dbSNP
rs1188431923 556 dbSNP
rs1446930419 557 dbSNP
rs961536 564 dbSNP
rs544747148 573 dbSNP
rs947296414 580 dbSNP
rs913145916 584 dbSNP
rs1390007023 587 dbSNP
rs988182741 589 dbSNP
rs1272830200 600 dbSNP
rs1457094773 606 dbSNP
rs1226851787 607 dbSNP
rs956675626 609 dbSNP
rs575678994 617 dbSNP
rs1397447120 621 dbSNP
rs774013674 627 dbSNP
rs1285738932 633 dbSNP
rs1339415763 646 dbSNP
rs977257954 648 dbSNP
rs964120584 651 dbSNP
rs1245240497 656 dbSNP
rs1364445093 657 dbSNP
rs1241948275 660 dbSNP
rs570686103 665 dbSNP
rs1018864510 675 dbSNP
rs1290212341 677 dbSNP
rs1295289494 681 dbSNP
rs1329763419 688 dbSNP
rs1227653087 689 dbSNP
rs768498680 696 dbSNP
rs1436700898 713 dbSNP
rs1201272442 717 dbSNP
rs947709592 723 dbSNP
rs1440831496 725 dbSNP
rs34421679 726 dbSNP
rs1184059336 730 dbSNP
rs1412720963 736 dbSNP
rs558749688 742 dbSNP
rs150370480 743 dbSNP
rs1025834078 747 dbSNP
rs759571869 748 dbSNP
rs1164263608 759 dbSNP
rs1475281417 767 dbSNP
rs1172842115 773 dbSNP
rs993822293 777 dbSNP
rs935098521 797 dbSNP
rs1393851365 799 dbSNP
rs1309332818 806 dbSNP
rs1350499330 820 dbSNP
rs1409171514 827 dbSNP
rs1388914331 829 dbSNP
rs1313792545 853 dbSNP
rs749097235 855 dbSNP
rs895499507 866 dbSNP
rs1255683982 869 dbSNP
rs2069688 877 dbSNP
rs141376959 882 dbSNP
rs1252665840 886 dbSNP
rs547273908 887 dbSNP
rs1180708203 889 dbSNP
rs1482740595 889 dbSNP
rs977626684 889 dbSNP
rs879564631 894 dbSNP
rs905578728 899 dbSNP
rs1252473650 906 dbSNP
rs1376214262 907 dbSNP
rs1464241013 914 dbSNP
rs1170040520 925 dbSNP
rs1370667064 926 dbSNP
rs1428501744 927 dbSNP
rs1306155373 933 dbSNP
rs536537852 946 dbSNP
rs947202991 947 dbSNP
rs567566627 960 dbSNP
rs1290844504 962 dbSNP
rs2069704 967 dbSNP
rs1230930841 973 dbSNP
rs1027635107 983 dbSNP
rs973446030 985 dbSNP
rs536782543 991 dbSNP
rs571332772 995 dbSNP
rs551159409 998 dbSNP
rs922594150 1004 dbSNP
rs976744367 1005 dbSNP
rs2069689 1006 dbSNP
rs911306878 1023 dbSNP
rs2069690 1031 dbSNP
rs1448426060 1039 dbSNP
rs1166184260 1045 dbSNP
rs952868630 1047 dbSNP
rs1025739366 1052 dbSNP
rs1458370197 1056 dbSNP
rs1292833064 1059 dbSNP
rs72777533 1065 dbSNP
rs79486762 1067 dbSNP
rs192155471 1071 dbSNP
rs1429557782 1072 dbSNP
rs1369128791 1075 dbSNP
rs758795409 1086 dbSNP
rs753309756 1089 dbSNP
rs547902182 1095 dbSNP
rs1226373243 1098 dbSNP
rs35656371 1099 dbSNP
rs1314955999 1109 dbSNP
rs1430961588 1111 dbSNP
rs1221515088 1115 dbSNP
rs1001203235 1119 dbSNP
rs905650002 1129 dbSNP
rs1395005963 1132 dbSNP
rs1209732124 1138 dbSNP
rs1247728074 1145 dbSNP
rs1448518409 1157 dbSNP
rs935067206 1168 dbSNP
rs1189606090 1169 dbSNP
rs1423860601 1172 dbSNP
rs531305010 1181 dbSNP
rs1041201082 1211 dbSNP
rs1458680018 1213 dbSNP
rs1181402973 1220 dbSNP
rs1482170978 1221 dbSNP
rs755333358 1225 dbSNP
rs1206943471 1228 dbSNP
rs543659800 1236 dbSNP
rs754257062 1246 dbSNP
rs145910089 1247 dbSNP
rs117606150 1254 dbSNP
rs1227785843 1255 dbSNP
rs1311274480 1256 dbSNP
rs891651103 1261 dbSNP
rs1346467166 1262 dbSNP
rs565383150 1264 dbSNP
rs1229493217 1273 dbSNP
rs1050680563 1282 dbSNP
rs1463795491 1289 dbSNP
rs1274882735 1293 dbSNP
rs1238824364 1294 dbSNP
rs760425620 1297 dbSNP
rs920587002 1314 dbSNP
rs1254687614 1325 dbSNP
rs1267489993 1328 dbSNP
rs933231332 1333 dbSNP
rs142445825 1339 dbSNP
rs1473539546 1342 dbSNP
rs1159751050 1343 dbSNP
rs1408862345 1347 dbSNP
rs923203812 1349 dbSNP
rs1310312594 1362 dbSNP
rs1178562569 1364 dbSNP
rs1359946687 1365 dbSNP
rs1410816167 1373 dbSNP
rs151054502 1387 dbSNP
rs749877946 1395 dbSNP
rs907929951 1396 dbSNP
rs562130982 1401 dbSNP
rs911324226 1402 dbSNP
rs984183531 1404 dbSNP
rs952775708 1406 dbSNP
rs1312415611 1412 dbSNP
rs1416621979 1418 dbSNP
rs1425994243 1419 dbSNP
rs1047494 1420 dbSNP
rs1182857626 1424 dbSNP
rs1471734647 1428 dbSNP
rs1250955310 1432 dbSNP
rs972843575 1435 dbSNP
rs536575075 1446 dbSNP
rs1425541602 1470 dbSNP
rs1012159767 1479 dbSNP
rs1171969604 1482 dbSNP
rs1483245274 1486 dbSNP
rs1236876042 1490 dbSNP
rs573977751 1491 dbSNP
rs1313831832 1509 dbSNP
rs960602931 1511 dbSNP
rs1439142952 1514 dbSNP
rs1227242584 1523 dbSNP
rs1367282417 1527 dbSNP
rs1326710511 1529 dbSNP
rs1277709448 1533 dbSNP
rs1343736531 1534 dbSNP
rs1035946148 1548 dbSNP
rs774288695 1556 dbSNP
rs557195493 1563 dbSNP
rs190680932 1570 dbSNP
rs1436008763 1575 dbSNP
rs1021273607 1577 dbSNP
rs866974005 1586 dbSNP
rs1229440624 1607 dbSNP
rs1247103804 1612 dbSNP
rs1477557750 1614 dbSNP
rs1192045331 1615 dbSNP
rs1392243309 1624 dbSNP
rs1450243279 1630 dbSNP
rs1011331469 1636 dbSNP
rs2069691 1637 dbSNP
rs1301414974 1647 dbSNP
rs185732573 1653 dbSNP
rs1360187240 1656 dbSNP
rs997355382 1665 dbSNP
rs901780728 1667 dbSNP
rs1414522729 1668 dbSNP
rs193230021 1672 dbSNP
rs1423424017 1673 dbSNP
rs1228594236 1674 dbSNP
rs762699223 1675 dbSNP
rs2069692 1677 dbSNP
rs565699692 1680 dbSNP
rs1230000067 1681 dbSNP
rs1290482934 1686 dbSNP
rs943252092 1687 dbSNP
rs2069693 1692 dbSNP
rs1249592500 1694 dbSNP
rs1465526439 1696 dbSNP
rs1207613613 1697 dbSNP
rs187480998 1702 dbSNP
rs1473799290 1704 dbSNP
rs940664740 1706 dbSNP
rs1413683327 1708 dbSNP
rs1460265207 1726 dbSNP
rs1048343742 1730 dbSNP
rs1463137056 1731 dbSNP
rs528861543 1736 dbSNP
rs1435406631 1751 dbSNP
rs878963131 1758 dbSNP
rs1269436720 1760 dbSNP
rs907892648 1765 dbSNP
rs1284779408 1769 dbSNP
rs1320686134 1771 dbSNP
rs982207691 1777 dbSNP
rs369823004 1779 dbSNP
rs116836657 1781 dbSNP
rs1329552572 1785 dbSNP
rs1208391012 1788 dbSNP
rs1259885760 1794 dbSNP
rs1444253056 1798 dbSNP
rs938846548 1802 dbSNP
rs991022670 1803 dbSNP
rs1236906531 1815 dbSNP
rs1474518588 1817 dbSNP
rs1380599297 1823 dbSNP
rs1297476508 1828 dbSNP
rs928912644 1829 dbSNP
rs1457026745 1832 dbSNP
rs1157697341 1836 dbSNP
rs139687205 1839 dbSNP
rs200663845 1840 dbSNP
rs2069694 1840 dbSNP
rs550055000 1843 dbSNP
rs1390964729 1844 dbSNP
rs1321246445 1845 dbSNP
rs1032232282 1856 dbSNP
rs533162021 1865 dbSNP
rs564118159 1869 dbSNP
rs970672954 1871 dbSNP
rs1350933822 1876 dbSNP
rs35717158 1880 dbSNP
rs1162501451 1884 dbSNP
rs1425314483 1894 dbSNP
rs999462171 1897 dbSNP
rs966347806 1900 dbSNP
rs1385832648 1903 dbSNP
rs1021306467 1913 dbSNP
rs989805445 1914 dbSNP
rs747299845 1917 dbSNP
rs1249367233 1918 dbSNP
rs1253153705 1924 dbSNP
rs1205138858 1930 dbSNP
rs773156893 1931 dbSNP
rs78370291 1935 dbSNP
rs1047529 1943 dbSNP
rs889572067 1944 dbSNP
rs182754102 1953 dbSNP
rs1374361052 1954 dbSNP
rs191769621 1955 dbSNP
rs1412192002 1963 dbSNP
rs899350679 1982 dbSNP
rs1351028098 1985 dbSNP
rs1390680009 1987 dbSNP
rs1322660120 1998 dbSNP
rs1047530 2008 dbSNP
rs371304065 2022 dbSNP
rs1007478901 2036 dbSNP
rs1345892510 2037 dbSNP
rs1207380942 2044 dbSNP
rs1046873750 2045 dbSNP
rs779408725 2046 dbSNP
rs1048417185 2047 dbSNP
rs1226866603 2061 dbSNP
rs949417559 2062 dbSNP
rs1394087151 2067 dbSNP
rs541873066 2072 dbSNP
rs1370569151 2080 dbSNP
rs1461438145 2084 dbSNP
rs931311626 2087 dbSNP
rs1392682908 2088 dbSNP
rs1387126541 2094 dbSNP
rs1298425921 2099 dbSNP
rs573669261 2100 dbSNP
rs1369061320 2101 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2151.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agggcccuugaguagUCAGAGg 5'
                         |||||| 
Target 5' ---------------AGUCUCa 3'
1 - 7
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000296641.4 | 3UTR | AGUCUCACUGUUGCCCAGGCUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-873-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081178 MIDN midnolin 2 4
MIRT109809 ZFX zinc finger protein, X-linked 2 4
MIRT242383 TMC5 transmembrane channel like 5 2 4
MIRT444003 METRN meteorin, glial cell differentiation regulator 2 4
MIRT444097 SEPHS1 selenophosphate synthetase 1 2 2
MIRT446158 RPL12 ribosomal protein L12 2 2
MIRT446859 SAMD9L sterile alpha motif domain containing 9 like 2 2
MIRT447275 FZD5 frizzled class receptor 5 2 2
MIRT447391 TMPRSS15 transmembrane protease, serine 15 2 2
MIRT448817 FKBP1A FK506 binding protein 1A 2 4
MIRT450582 HIST1H2BG histone cluster 1 H2B family member g 2 2
MIRT451776 USP36 ubiquitin specific peptidase 36 2 2
MIRT457961 ABCC5 ATP binding cassette subfamily C member 5 2 4
MIRT458424 KLHL38 kelch like family member 38 2 4
MIRT461383 SLFN12L schlafen family member 12 like 2 2
MIRT467793 SLC2A14 solute carrier family 2 member 14 2 2
MIRT476517 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT480290 C7orf73 short transmembrane mitochondrial protein 1 2 4
MIRT482745 HES7 hes family bHLH transcription factor 7 2 10
MIRT483189 HIST1H2AH histone cluster 1 H2A family member h 2 6
MIRT486545 DCTN4 dynactin subunit 4 2 2
MIRT486581 ZNF619 zinc finger protein 619 2 2
MIRT492604 POLR3E RNA polymerase III subunit E 2 2
MIRT494130 DCAF7 DDB1 and CUL4 associated factor 7 2 6
MIRT496023 ZBED3 zinc finger BED-type containing 3 2 2
MIRT497121 NBEAL1 neurobeachin like 1 2 2
MIRT497400 TMEM245 transmembrane protein 245 2 2
MIRT501410 RANBP10 RAN binding protein 10 2 2
MIRT510947 PPTC7 PTC7 protein phosphatase homolog 2 6
MIRT512494 ARID2 AT-rich interaction domain 2 2 2
MIRT512595 ZNF783 zinc finger family member 783 2 2
MIRT512612 CNTN4 contactin 4 2 2
MIRT517808 UGDH UDP-glucose 6-dehydrogenase 2 6
MIRT520686 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT526179 HEPH hephaestin 2 2
MIRT532568 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT533979 TADA2A transcriptional adaptor 2A 2 2
MIRT538622 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539703 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT539806 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT540422 FAM83F family with sequence similarity 83 member F 2 2
MIRT540506 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT540619 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT542423 ZNF331 zinc finger protein 331 2 2
MIRT542454 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT543383 CC2D2A coiled-coil and C2 domain containing 2A 2 2
MIRT544777 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT544923 ERCC4 ERCC excision repair 4, endonuclease catalytic subunit 2 2
MIRT549768 ZNF611 zinc finger protein 611 2 4
MIRT551242 COLEC10 collectin subfamily member 10 2 2
MIRT560474 ENSA endosulfine alpha 2 2
MIRT569738 GPR173 G protein-coupled receptor 173 2 2
MIRT571297 CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2 2
MIRT572345 CKAP2L cytoskeleton associated protein 2 like 2 2
MIRT573112 ERBB2IP erbb2 interacting protein 2 2
MIRT607744 ANGPT4 angiopoietin 4 2 2
MIRT607903 SPRYD4 SPRY domain containing 4 2 2
MIRT611744 SERPING1 serpin family G member 1 2 4
MIRT615101 BNC2 basonuclin 2 2 2
MIRT619124 CD40LG CD40 ligand 2 2
MIRT625572 ANKRD42 ankyrin repeat domain 42 2 2
MIRT629038 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633986 SLC35E2 solute carrier family 35 member E2 2 2
MIRT635675 COX18 COX18, cytochrome c oxidase assembly factor 2 4
MIRT637471 DEFB105B defensin beta 105B 2 4
MIRT637503 DEFB105A defensin beta 105A 2 4
MIRT639735 MAP2K2 mitogen-activated protein kinase kinase 2 2 2
MIRT640730 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT645364 C9orf47 chromosome 9 open reading frame 47 2 2
MIRT647938 RNF152 ring finger protein 152 2 2
MIRT649400 SH2D4A SH2 domain containing 4A 2 2
MIRT656860 KIN Kin17 DNA and RNA binding protein 2 2
MIRT663470 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT663507 NKAPL NFKB activating protein like 2 4
MIRT667690 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT677403 PCNP PEST proteolytic signal containing nuclear protein 2 2
MIRT678682 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT678789 NUPL2 nucleoporin like 2 2 2
MIRT680649 KIAA1456 KIAA1456 2 2
MIRT682450 MTX3 metaxin 3 2 2
MIRT682740 CA6 carbonic anhydrase 6 2 2
MIRT684421 TUFT1 tuftelin 1 2 2
MIRT690535 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT690595 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT690771 PLA2G2C phospholipase A2 group IIC 2 2
MIRT692233 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT693667 MXRA7 matrix remodeling associated 7 2 2
MIRT695551 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT695870 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT696214 LYZ lysozyme 2 2
MIRT698368 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT700795 PHTF2 putative homeodomain transcription factor 2 2 2
MIRT701640 MYLK3 myosin light chain kinase 3 2 2
MIRT702989 HERPUD2 HERPUD family member 2 2 2
MIRT703627 FBXL3 F-box and leucine rich repeat protein 3 2 2
MIRT703783 FAM102B family with sequence similarity 102 member B 2 2
MIRT704293 DDX19B DEAD-box helicase 19B 2 2
MIRT704828 CDC73 cell division cycle 73 2 2
MIRT705014 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT708480 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT710770 PHF7 PHD finger protein 7 2 2
MIRT718918 TRIM66 tripartite motif containing 66 2 2
MIRT720390 ZNF549 zinc finger protein 549 2 2
MIRT720593 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT723515 SIGLEC8 sialic acid binding Ig like lectin 8 2 2
MIRT724458 PRKX protein kinase, X-linked 2 2
MIRT737267 UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 3 0
MIRT737356 ZIC2 Zic family member 2 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-873 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-873 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-873 Cisplatin 5460033 NSC119875 approved resistant cell line (OE19)
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-873 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-873-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-873-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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