miRTarBase - #MIRT540830


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pre-miRNA Information
pre-miRNA hsa-mir-4524a   
Genomic Coordinates chr17: 69099564 - 69099632
Description Homo sapiens miR-4524a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524a-5p
Sequence 6| AUAGCAGCAUGAACCUGUCUCA |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322445998 8 dbSNP
rs1350790266 13 dbSNP
rs1263495678 21 dbSNP
Putative Targets

Gene Information
Gene Symbol GNAT1   
Synonyms CSNB1G, CSNBAD3, GBT1, GNATR
Description G protein subunit alpha transducin 1
Transcript NM_144499   
Other Transcripts NM_000172   
Expression
Putative miRNA Targets on GNAT1
3'UTR of GNAT1
(miRNA target sites are highlighted)		 
>GNAT1|NM_144499|3'UTR
   1 GGTGCCTGAATTCATGCGTGTCAGTCACCCTGAGACCTGGTAGCCCTAGCTGCCTTGCAGCCCCAAACCCCAGGACCCTA
  81 TCAGCCCCCTGGGACTCCCTGGCCCCAACCTGCCACCTCACCAAAGCTCTGAGCCCTGCTAGCCTTGAGGCGCGGACCCT
 161 CCCCCATACCTCCCACAGTATCCCAGCGCCTCATGCCCCCAACCCCAAGCCCTGCCCTTCACCGCCCGGCTGCACTGGCC
 241 TCTAGGACTCACAGCAGCCAGCCCCAGCTAGGAACGGGCAGGACTTGGGGCAGCTGAAGCTCACGGTGACTCAGCAGTGC
 321 CCAACTGACCAATCTCCCGCAGCTCTCCTGCCCCTGGGGGCCCACGACTCACCTGGTGGGCCTGGGCTCAGCAAACAGCC
 401 CTCCCTCCCAGTATTTCATCAAGGACAGGGAATATCCCTCCCACACACAGGCCAGCTGCTCACCCTGCCACCTCCATGTG
 481 ACAAGTTTGACACCTGTCTACCCAGAGCCAGTGACTGTCCCTCCCAGCAGCCTCCAAAGGGTCCAAAGTCCAAGCTAGCT
 561 CTGGCCTGTGTGGCCCCCACATAAATAAATTAGTGGGGAGGGGGCAGACCTGGGGGCCCTTGGGTGCCAGAGTGAGACAC
 641 AGCAGGACCCTTCCCCAAATACTAGGCTCAGAGCAACCTCCAGCCTTCTCCAGCAGGATCTGCTCCCTGTGTCCTTGGAC
 721 AGCAGATCCACACACCACTTCCCCACCCACACACAGTACCCTGGGCTGGTTGGACAACAGGATGGTGTGTTAAGGGGTTA
 801 AGGGAGGGTACTGTTGACACCAGCTATGGCCAATAGCTGGGCTGTCCTGAGGGGTGGCTGGGGACAGAGTCCAGCTCCCT
 881 TGGATCAGCCCAGAGGATTCAGGATAGGACAAAGGCCCTGGCTGTGCCCAAAAGGGTCTACCTCAGGTGGGGTTACAAGC
 961 AAACCTGGGTGACCCTCTTGTCCCTACCAGCAGCTTCTCTTGCCCCTTCCATTCAGGGTTCCCTGGCAGGGGAAGCTGAG
1041 AGCCATGGCTGAACTATCAGGGACAAAGGCCCATGTCCCCACATCCCTGCTCCCTCCTTCCTCATCCAGCACCAAATCTT
1121 TGCTTATGTCCACAGGCCAGGGCCTGTGCTGCAGTCGGGGACAAGGAGCTTCCGTCTGGCAAGGCCGGGGCACAATTTGC
1201 ACTCCCCTCAGCTAGACGCACAGACTCAGCAATAAACCTTTGCATCAGGCTCCAGCTGTCCTTTCTTGGTGGAGGACTTA
1281 ATTATCACAAGTCATGGGCATTTATTAAGTGCCCAGTGCTGGGTTGGGCATGAAGTGGGAAGATGGCCCCTCCCAGGAAG
1361 AAGTACCTGGCCTGACAAGGTGGGGCACTCTTGGGGGTATGGGACCAACTCATGGCTTTTCACGGGAGTTGAGGAGAGAG
1441 GAGCTGTGGAAAATATTCACTGGGACAGTCTTGGATCAAGAGGGAGTTTTGAGGTGGAGGCTCATTCTGGCAGGGACCGT
1521 AGTGTCTACCAGCCCCAGAAACATGGGCTTATGGCCACAGGAGTTCAGTGGAGCAAGAGCAGGGGAGGAGAGACGTGGAC
1601 AGGTGCCCAAAGCCAGTCGGAGGGCCTGGGCTTTCTCAGAAGGTGATGGAGAGTCTTGGAAGCCCTCGAGGCAGGAACAT
1681 AATTGCAGGGCTGGGATTAGGGTGAGGGAAGTGAGGCACACTCACCTTGGGTGCAACATTTAAGGCGATGCCAAAAAATT
1761 TAGTAACCAAGGTAAATAATATTAGGATAATATTTTTAAAAATCAAATGAATGCAAAACCCCACAATGAATGAAATATCA
1841 AAATCCAACAGAGGATCAAACAGAGGCATGCTAAGATATATTGGGGCTTGAAGCAAAGGGAAAACTATTTGTTGCTATAT
1921 GTTTGTAGGGATTTTTTGCCAGTTTTAAAAATACATGTATCATAAAGTTTACTATCTCAGCCACTTGCCGGTGTATAGTT
2001 TGGTGGTGTTAAGTACATTCATAATGTTGTACAACCACCGCAACTGTTCATCTCCAGAACTCCTTTCCTCTTGTAAAACT
2081 GTAACTCTGTACCCATGAAAAAATAACCCCCCATTCCTGCCTTCCCCCGGCTCCTGGCATCCACCATTCTACTTTCCATC
2161 TCTATGAATGTGACTGCTCTAAGTGCCTCAGATGTGTGGGTCCATGAAGTCTTTGTCTTTTTGCAACTGGCTTATTTCAC
2241 TTAGCATCATGTCTTCAAGGTTTATTCATGTGTAGCATATGGCAGAATCTCCTTCCTTTTTAAGGTTGAATAATATTCCA
2321 TTGTATATATTCCACACTTTGTTTATTTATTCATCTATTGATGAATGGTTACATCTGCCTTTTGGCTATTGTGAATAATG
2401 CTGCTATGAACATGGGTGTACAAATCTCTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acucuguccaAGUACGACGAUa 5'
                    | ||||||||| 
Target 5' ctattgtgaaTAATGCTGCTAt 3'
 2386 - 2407 152.00 -12.50
2 
miRNA  3' acUCUGUCCAAGUACGACGAua 5'
            | |||||  || ||||||  
Target 5' acACACAGG-CCA-GCTGCTca 3'
 443 - 462 138.00 -14.10
3 
miRNA  3' acUCUGUCCAAGUACGACGAUa 5'
            :|| |  | : ||:||||| 
Target 5' agGGAAAACTATTTGTTGCTAt 3'
 1897 - 1918 136.00 -13.29
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
346056 317 ClinVar
346057 440 ClinVar
346058 495 ClinVar
346059 722 ClinVar
346060 828 ClinVar
346061 863 ClinVar
346062 930 ClinVar
900948 990 ClinVar
900949 1040 ClinVar
900950 1118 ClinVar
900951 1146 ClinVar
900952 1215 ClinVar
346063 1413 ClinVar
346064 1486 ClinVar
346065 1499 ClinVar
346066 1517 ClinVar
902605 1586 ClinVar
346067 1681 ClinVar
346068 1691 ClinVar
346069 1709 ClinVar
346070 1739 ClinVar
346071 2101 ClinVar
346072 2266 ClinVar
903455 2302 ClinVar
346073 2303 ClinVar
903456 2358 ClinVar
346074 2386 ClinVar
903457 2440 ClinVar
346075 2441 ClinVar
346076 2579 ClinVar
899842 2641 ClinVar
COSN9553184 580 COSMIC
COSN8489356 635 COSMIC
COSN26671230 809 COSMIC
COSN9553185 876 COSMIC
COSN31595067 1020 COSMIC
COSN1951881 1208 COSMIC
COSN1278157 1240 COSMIC
COSN31546605 1430 COSMIC
COSN28214283 1432 COSMIC
COSN1951882 1446 COSMIC
COSN25130677 1481 COSMIC
COSN31548158 1537 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1327802052 3 dbSNP
rs1433394374 9 dbSNP
rs761706596 10 dbSNP
rs1341851682 11 dbSNP
rs1226850044 14 dbSNP
rs769640410 15 dbSNP
rs888476052 16 dbSNP
rs1165317170 23 dbSNP
rs1199908126 25 dbSNP
rs773042928 28 dbSNP
rs762522988 32 dbSNP
rs1194118214 35 dbSNP
rs1350003742 36 dbSNP
rs1452717664 37 dbSNP
rs1247189667 38 dbSNP
rs1005574197 39 dbSNP
rs371682974 40 dbSNP
rs765987827 44 dbSNP
rs769298650 48 dbSNP
rs1395608821 49 dbSNP
rs1173315128 54 dbSNP
rs538206472 61 dbSNP
rs1189739744 62 dbSNP
rs1490891217 63 dbSNP
rs1015607873 65 dbSNP
rs1197866139 66 dbSNP
rs1456389066 71 dbSNP
rs1259702628 74 dbSNP
rs1180247711 86 dbSNP
rs1311437538 87 dbSNP
rs1298698579 93 dbSNP
rs1220662543 98 dbSNP
rs1367627407 100 dbSNP
rs961455350 102 dbSNP
rs771446719 104 dbSNP
rs879758332 106 dbSNP
rs998331779 108 dbSNP
rs1359018977 113 dbSNP
rs1412174618 114 dbSNP
rs913389042 123 dbSNP
rs947518391 128 dbSNP
rs1163401946 139 dbSNP
rs372493492 139 dbSNP
rs1365690988 147 dbSNP
rs1179220811 148 dbSNP
rs1030246660 157 dbSNP
rs1254086584 159 dbSNP
rs370095962 163 dbSNP
rs1312442508 164 dbSNP
rs1284627687 166 dbSNP
rs1426061987 168 dbSNP
rs1378528635 170 dbSNP
rs1312096142 173 dbSNP
rs776806625 177 dbSNP
rs1043551029 182 dbSNP
rs1376314216 195 dbSNP
rs964742743 196 dbSNP
rs1158321836 204 dbSNP
rs764282254 205 dbSNP
rs1417904555 218 dbSNP
rs75051862 227 dbSNP
rs1382321203 231 dbSNP
rs1159728009 234 dbSNP
rs975732453 240 dbSNP
rs1349569246 241 dbSNP
rs919886928 241 dbSNP
rs952640685 254 dbSNP
rs546061610 255 dbSNP
rs1214087545 259 dbSNP
rs1355215944 262 dbSNP
rs1286129825 265 dbSNP
rs556462480 272 dbSNP
rs1240300116 278 dbSNP
rs372477077 283 dbSNP
rs1321673225 284 dbSNP
rs28560184 285 dbSNP
rs1310961925 289 dbSNP
rs558437767 291 dbSNP
rs1398130761 295 dbSNP
rs1356546063 308 dbSNP
rs1376829787 312 dbSNP
rs1398447437 313 dbSNP
rs1362473809 316 dbSNP
rs554301590 317 dbSNP
rs968398635 319 dbSNP
rs938378851 325 dbSNP
rs978435874 329 dbSNP
rs924320609 330 dbSNP
rs1361647308 331 dbSNP
rs1190988097 332 dbSNP
rs867795421 334 dbSNP
rs1489067262 346 dbSNP
rs1261761393 348 dbSNP
rs934398523 349 dbSNP
rs1208745290 357 dbSNP
rs1487245983 363 dbSNP
rs1264170370 370 dbSNP
rs1247710439 372 dbSNP
rs1056960489 375 dbSNP
rs1203177323 382 dbSNP
rs1274179813 385 dbSNP
rs1216987457 398 dbSNP
rs1342636748 399 dbSNP
rs1438610694 400 dbSNP
rs1386253797 401 dbSNP
rs34343340 408 dbSNP
rs757575839 408 dbSNP
rs1295209110 421 dbSNP
rs1461909690 439 dbSNP
rs886058686 440 dbSNP
rs1229282097 442 dbSNP
rs915561481 456 dbSNP
rs1478568245 461 dbSNP
rs374490377 464 dbSNP
rs888381257 465 dbSNP
rs1043691148 466 dbSNP
rs779164728 470 dbSNP
rs999079015 473 dbSNP
rs1216034721 476 dbSNP
rs1469308740 491 dbSNP
rs556104512 495 dbSNP
rs1197116906 498 dbSNP
rs377626081 499 dbSNP
rs1232887540 500 dbSNP
rs1037003413 504 dbSNP
rs897206711 507 dbSNP
rs1441491829 508 dbSNP
rs1399480138 518 dbSNP
rs1329282634 521 dbSNP
rs1466960532 527 dbSNP
rs1053185346 535 dbSNP
rs1029825155 536 dbSNP
rs954387641 537 dbSNP
rs1445920943 539 dbSNP
rs1007125518 540 dbSNP
rs1022532417 550 dbSNP
rs1177391744 556 dbSNP
rs1439909018 559 dbSNP
rs890629465 561 dbSNP
rs1200023258 569 dbSNP
rs1343181431 570 dbSNP
rs1008896594 572 dbSNP
rs1017682247 583 dbSNP
rs1235080688 587 dbSNP
rs1251837444 588 dbSNP
rs1306981247 589 dbSNP
rs968295712 597 dbSNP
rs1336066502 603 dbSNP
rs978382230 612 dbSNP
rs1031378299 616 dbSNP
rs1403876767 620 dbSNP
rs1347025046 621 dbSNP
rs965064109 624 dbSNP
rs750880836 634 dbSNP
rs746393949 636 dbSNP
rs1330597940 637 dbSNP
rs994876223 643 dbSNP
rs1357185306 644 dbSNP
rs1027298514 645 dbSNP
rs1233768367 648 dbSNP
rs575872240 649 dbSNP
rs1315627561 650 dbSNP
rs758830334 651 dbSNP
rs1226184433 652 dbSNP
rs1296982858 654 dbSNP
rs1340262012 655 dbSNP
rs1216579007 663 dbSNP
rs952630629 668 dbSNP
rs917070864 677 dbSNP
rs566079513 678 dbSNP
rs1351351082 682 dbSNP
rs982704345 684 dbSNP
rs1283575864 693 dbSNP
rs979971972 707 dbSNP
rs780676955 708 dbSNP
rs1463946373 712 dbSNP
rs1313095276 714 dbSNP
rs1399024028 716 dbSNP
rs539933815 717 dbSNP
rs1299528447 719 dbSNP
rs557823715 722 dbSNP
rs897196783 723 dbSNP
rs780959675 729 dbSNP
rs1163233656 742 dbSNP
rs992570816 743 dbSNP
rs915693790 757 dbSNP
rs1188853947 775 dbSNP
rs1422688533 776 dbSNP
rs1413693465 781 dbSNP
rs1261071999 784 dbSNP
rs1218066579 789 dbSNP
rs542363943 792 dbSNP
rs948373497 794 dbSNP
rs1007433477 795 dbSNP
rs747827532 796 dbSNP
rs1408129627 809 dbSNP
rs1217587881 810 dbSNP
rs1042708995 813 dbSNP
rs925620839 814 dbSNP
rs561000136 815 dbSNP
rs999811481 827 dbSNP
rs11919418 828 dbSNP
rs955922068 829 dbSNP
rs543412201 831 dbSNP
rs1397057881 837 dbSNP
rs1166143235 846 dbSNP
rs890619565 853 dbSNP
rs1477590675 862 dbSNP
rs116031664 863 dbSNP
rs1024445619 867 dbSNP
rs1475774496 870 dbSNP
rs1246212799 889 dbSNP
rs1273296220 906 dbSNP
rs1039515303 907 dbSNP
rs900607836 909 dbSNP
rs762876255 926 dbSNP
rs13064381 930 dbSNP
rs547652490 944 dbSNP
rs886442940 945 dbSNP
rs1273523270 964 dbSNP
rs1197751906 965 dbSNP
rs1315884105 973 dbSNP
rs1224443324 977 dbSNP
rs1214859485 983 dbSNP
rs1004131014 990 dbSNP
rs1015555149 993 dbSNP
rs4525859 1000 dbSNP
rs979867388 1007 dbSNP
rs1373858291 1010 dbSNP
rs1327221284 1017 dbSNP
rs565732698 1019 dbSNP
rs1465429070 1022 dbSNP
rs1263112376 1025 dbSNP
rs529849594 1030 dbSNP
rs1353180264 1035 dbSNP
rs774324843 1040 dbSNP
rs1410748932 1046 dbSNP
rs1424495427 1058 dbSNP
rs972655698 1064 dbSNP
rs1455673773 1067 dbSNP
rs959845513 1082 dbSNP
rs1178018186 1084 dbSNP
rs1479911747 1087 dbSNP
rs1456270044 1088 dbSNP
rs1252871144 1094 dbSNP
rs1204698924 1099 dbSNP
rs1275834493 1100 dbSNP
rs1311284244 1100 dbSNP
rs992681695 1106 dbSNP
rs1023236928 1109 dbSNP
rs574271694 1118 dbSNP
rs541669583 1119 dbSNP
rs978929100 1120 dbSNP
rs925604888 1139 dbSNP
rs760716503 1146 dbSNP
rs1446710309 1147 dbSNP
rs560184290 1148 dbSNP
rs1371543817 1151 dbSNP
rs1300297135 1165 dbSNP
rs868087123 1166 dbSNP
rs527349690 1168 dbSNP
rs1358775478 1171 dbSNP
rs1172047096 1177 dbSNP
rs764186472 1182 dbSNP
rs933962774 1185 dbSNP
rs549216868 1193 dbSNP
rs1321684599 1206 dbSNP
rs567722015 1207 dbSNP
rs1177594508 1212 dbSNP
rs912176233 1215 dbSNP
rs1285479371 1236 dbSNP
rs554235272 1239 dbSNP
rs574511924 1240 dbSNP
rs942836441 1246 dbSNP
rs1240005910 1249 dbSNP
rs900675472 1253 dbSNP
rs1309843269 1261 dbSNP
rs930705934 1270 dbSNP
rs1378982228 1271 dbSNP
rs1311281085 1272 dbSNP
rs1261818320 1276 dbSNP
rs1353471826 1280 dbSNP
rs1206320363 1284 dbSNP
rs1297695814 1285 dbSNP
rs571648848 1287 dbSNP
rs1287154961 1293 dbSNP
rs1365443237 1299 dbSNP
rs1159796977 1301 dbSNP
rs1423013663 1305 dbSNP
rs1490072751 1318 dbSNP
rs1189536824 1322 dbSNP
rs1485811697 1327 dbSNP
rs904048118 1328 dbSNP
rs999760072 1333 dbSNP
rs1031234781 1339 dbSNP
rs538461295 1348 dbSNP
rs1263011334 1349 dbSNP
rs896747210 1358 dbSNP
rs1321442822 1363 dbSNP
rs879811738 1381 dbSNP
rs1471479495 1386 dbSNP
rs1180829735 1387 dbSNP
rs538946106 1389 dbSNP
rs1277859107 1390 dbSNP
rs1387320749 1398 dbSNP
rs886058687 1413 dbSNP
rs1014302496 1425 dbSNP
rs1364254124 1438 dbSNP
rs1455303398 1440 dbSNP
rs1161494866 1444 dbSNP
rs1004914296 1446 dbSNP
rs1475439149 1450 dbSNP
rs554401168 1455 dbSNP
rs1422430516 1458 dbSNP
rs1190658477 1463 dbSNP
rs1365006820 1464 dbSNP
rs1261840893 1465 dbSNP
rs1023977090 1468 dbSNP
rs377222546 1469 dbSNP
rs1215919562 1472 dbSNP
rs970209995 1474 dbSNP
rs572562871 1476 dbSNP
rs1257661781 1479 dbSNP
rs1225535951 1483 dbSNP
rs1328207351 1485 dbSNP
rs114828382 1486 dbSNP
rs1016710383 1498 dbSNP
rs192468377 1499 dbSNP
rs1014598066 1501 dbSNP
rs1165738961 1503 dbSNP
rs1409521467 1516 dbSNP
rs886058688 1517 dbSNP
rs918472141 1529 dbSNP
rs576063928 1530 dbSNP
rs1197580158 1532 dbSNP
rs987202438 1536 dbSNP
rs1452084711 1541 dbSNP
rs1022766234 1551 dbSNP
rs1337997518 1558 dbSNP
rs183851764 1561 dbSNP
rs761974103 1567 dbSNP
rs942747309 1568 dbSNP
rs1172963442 1570 dbSNP
rs1243291692 1572 dbSNP
rs1284165175 1579 dbSNP
rs1043856138 1585 dbSNP
rs891084737 1586 dbSNP
rs978533911 1589 dbSNP
rs1345897305 1593 dbSNP
rs1033210684 1594 dbSNP
rs1305517249 1595 dbSNP
rs1052611572 1596 dbSNP
rs564641622 1607 dbSNP
rs955694046 1609 dbSNP
rs1251012417 1610 dbSNP
rs1392725890 1612 dbSNP
rs1420700515 1612 dbSNP
rs141521241 1624 dbSNP
rs577257104 1630 dbSNP
rs1432322095 1631 dbSNP
rs988460257 1631 dbSNP
rs1045802112 1634 dbSNP
rs905557444 1635 dbSNP
rs911576803 1636 dbSNP
rs1180077423 1639 dbSNP
rs944930814 1642 dbSNP
rs1251507361 1643 dbSNP
rs1210503735 1656 dbSNP
rs1484697126 1672 dbSNP
rs1282574408 1679 dbSNP
rs563891409 1681 dbSNP
rs541334685 1686 dbSNP
rs1165548116 1687 dbSNP
rs766209614 1688 dbSNP
rs886058689 1691 dbSNP
rs559557322 1698 dbSNP
rs955462068 1706 dbSNP
rs74718377 1709 dbSNP
rs1394701402 1713 dbSNP
rs1336636227 1718 dbSNP
rs1418616294 1720 dbSNP
rs1384267937 1728 dbSNP
rs886545847 1735 dbSNP
rs548345252 1736 dbSNP
rs34877766 1739 dbSNP
rs896498306 1748 dbSNP
rs1364749098 1753 dbSNP
rs1316563911 1775 dbSNP
rs1339589274 1787 dbSNP
rs1187404173 1799 dbSNP
rs1474368906 1823 dbSNP
rs780402124 1827 dbSNP
rs1259649148 1829 dbSNP
rs146349746 1830 dbSNP
rs1014135554 1831 dbSNP
rs1282061008 1841 dbSNP
rs754793155 1842 dbSNP
rs1206889626 1845 dbSNP
rs1351057364 1873 dbSNP
rs1292481596 1875 dbSNP
rs1044747667 1877 dbSNP
rs549813093 1893 dbSNP
rs765142440 1894 dbSNP
rs1198589689 1895 dbSNP
rs1293571964 1897 dbSNP
rs1398840095 1898 dbSNP
rs1053032157 1906 dbSNP
rs918127997 1907 dbSNP
rs1242386048 1911 dbSNP
rs1461719527 1925 dbSNP
rs1000466596 1928 dbSNP
rs571313353 1930 dbSNP
rs538609813 1931 dbSNP
rs955767836 1932 dbSNP
rs1420257670 1937 dbSNP
rs547792902 1979 dbSNP
rs1171368784 1980 dbSNP
rs1475118346 1981 dbSNP
rs936981908 1986 dbSNP
rs1195159636 2001 dbSNP
rs1038010426 2002 dbSNP
rs1272519926 2013 dbSNP
rs1211555939 2015 dbSNP
rs1336759056 2019 dbSNP
rs898213119 2020 dbSNP
rs1375058592 2023 dbSNP
rs993910540 2028 dbSNP
rs1271458344 2031 dbSNP
rs1433447890 2032 dbSNP
rs1366533027 2042 dbSNP
rs1176180814 2049 dbSNP
rs1325878053 2051 dbSNP
rs752149774 2055 dbSNP
rs1009954142 2058 dbSNP
rs890983009 2059 dbSNP
rs1409614997 2063 dbSNP
rs1455086357 2070 dbSNP
rs1417403426 2075 dbSNP
rs754490248 2091 dbSNP
rs1169700103 2097 dbSNP
rs187475557 2101 dbSNP
rs1191727505 2103 dbSNP
rs1359232688 2109 dbSNP
rs1381221814 2110 dbSNP
rs1018161585 2115 dbSNP
rs1295848311 2115 dbSNP
rs1308902871 2117 dbSNP
rs536472605 2118 dbSNP
rs78066942 2119 dbSNP
rs1262298770 2120 dbSNP
rs1324134757 2121 dbSNP
rs975014616 2133 dbSNP
rs1274744368 2136 dbSNP
rs922205182 2151 dbSNP
rs1346613224 2172 dbSNP
rs963964049 2179 dbSNP
rs952226178 2180 dbSNP
rs979387074 2189 dbSNP
rs1032383955 2195 dbSNP
rs1485575738 2197 dbSNP
rs192031519 2198 dbSNP
rs988273610 2203 dbSNP
rs550472031 2224 dbSNP
rs908052780 2228 dbSNP
rs1394567939 2253 dbSNP
rs1171604893 2256 dbSNP
rs377634380 2266 dbSNP
rs1056567553 2267 dbSNP
rs1395400506 2268 dbSNP
rs917923627 2274 dbSNP
rs948085957 2286 dbSNP
rs1044308646 2301 dbSNP
rs184223436 2302 dbSNP
rs886058690 2303 dbSNP
rs1345191033 2318 dbSNP
rs1485026138 2321 dbSNP
rs1277579572 2336 dbSNP
rs926845370 2336 dbSNP
rs1288959578 2349 dbSNP
rs1363569789 2351 dbSNP
rs747737546 2352 dbSNP
rs1281429155 2353 dbSNP
rs942292553 2358 dbSNP
rs1282284035 2364 dbSNP
rs886058691 2386 dbSNP
rs1345887447 2391 dbSNP
rs1436718927 2397 dbSNP
rs1359643447 2403 dbSNP
rs1037990866 2404 dbSNP
rs898193350 2405 dbSNP
rs929695232 2406 dbSNP
rs1177357288 2407 dbSNP
rs891638520 2416 dbSNP
rs568815593 2424 dbSNP
rs1018683663 2428 dbSNP
rs558638425 2437 dbSNP
rs1315430836 2439 dbSNP
rs879841527 2440 dbSNP
rs886058692 2441 dbSNP
rs868408559 2458 dbSNP
rs1291710940 2466 dbSNP
rs1416698380 2472 dbSNP
rs996266869 2478 dbSNP
rs1466554880 2479 dbSNP
rs1288162158 2482 dbSNP
rs1262599661 2484 dbSNP
rs1028675435 2495 dbSNP
rs1346705025 2499 dbSNP
rs1159661892 2505 dbSNP
rs1460762193 2506 dbSNP
rs952365287 2516 dbSNP
rs1415203399 2519 dbSNP
rs1189697856 2522 dbSNP
rs1423831875 2523 dbSNP
rs1000820026 2543 dbSNP
rs1186401138 2550 dbSNP
rs985047378 2558 dbSNP
rs1269946410 2573 dbSNP
rs1263064674 2577 dbSNP
rs956716172 2578 dbSNP
rs886058693 2579 dbSNP
rs1180481119 2583 dbSNP
rs1235389494 2587 dbSNP
rs1322336061 2589 dbSNP
rs1294987834 2590 dbSNP
rs1407824755 2613 dbSNP
rs576916447 2626 dbSNP
rs1321213291 2628 dbSNP
rs962246241 2631 dbSNP
rs1159139687 2636 dbSNP
rs187096133 2641 dbSNP
rs1422264127 2644 dbSNP
rs1392035597 2647 dbSNP
rs980926146 2649 dbSNP
rs1365880696 2652 dbSNP
rs1458119971 2681 dbSNP
rs926835285 2684 dbSNP
rs1167671943 2687 dbSNP
rs918035912 2691 dbSNP
rs1250445334 2697 dbSNP
rs1189846031 2703 dbSNP
rs948063105 2705 dbSNP
rs942271590 2711 dbSNP
rs1251531379 2716 dbSNP
rs1045449569 2718 dbSNP
rs1277567910 2725 dbSNP
rs925321276 2730 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2779.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acucuguccaAGUACGACGAUa 5'
                    | ||||||||| 
Target 5' --auugugaaUAAUGCUGCUAu 3'
 		1 - 20
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293/HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1067870. RNA binding protein: AGO2. Condition:Ago2 IP-seq (mitotic cells) ...

- Kishore S; Gruber AR; Jedlinski DJ; Syed et al., 2013, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acucuguccaAGUACGACGAUa 5'
                    | ||||||||| 
Target 5' cuauugugaaUAAUGCUGCUAu 3'
 		8 - 29
Article - Kishore S; Gruber AR; Jedlinski DJ; Syed et al.
- Genome biology, 2013
BACKGROUND: In recent years, a variety of small RNAs derived from other RNAs with well-known functions such as tRNAs and snoRNAs, have been identified. The functional relevance of these RNAs is largely unknown. To gain insight into the complexity of snoRNA processing and the functional relevance of snoRNA-derived small RNAs, we sequence long and short RNAs, small RNAs that co-precipitate with the Argonaute 2 protein and RNA fragments obtained in photoreactive nucleotide-enhanced crosslinking and immunoprecipitation (PAR-CLIP) of core snoRNA-associated proteins. RESULTS: Analysis of these data sets reveals that many loci in the human genome reproducibly give rise to C/D box-like snoRNAs, whose expression and evolutionary conservation are typically less pronounced relative to the snoRNAs that are currently cataloged. We further find that virtually all C/D box snoRNAs are specifically processed inside the regions of terminal complementarity, retaining in the mature form only 4-5 nucleotides upstream of the C box and 2-5 nucleotides downstream of the D box. Sequencing of the total and Argonaute 2-associated populations of small RNAs reveals that despite their cellular abundance, C/D box-derived small RNAs are not efficiently incorporated into the Ago2 protein. CONCLUSIONS: We conclude that the human genome encodes a large number of snoRNAs that are processed along the canonical pathway and expressed at relatively low levels. Generation of snoRNA-derived processing products with alternative, particularly miRNA-like, functions appears to be uncommon.
LinkOut: [PMID: 23706177]
CLIP-seq Support 1 for dataset GSM1067870
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293/HeLa / Ago2 IP-seq (mitotic cells)
Location of target site ENST00000232461.3 | 3UTR | CUUUUGGCUAUUGUGAAUAAUGCUGCUAUGAACAUGGGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23706177 / GSE43666
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000232461.3 | 3UTR | AUUGUGAAUAAUGCUGCUAUGAACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
180 hsa-miR-4524a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055251 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT055826 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT060573 CCND1 cyclin D1 2 2
MIRT061013 C1ORF21 chromosome 1 open reading frame 21 2 6
MIRT064694 CCND2 cyclin D2 2 4
MIRT075268 SNTB2 syntrophin beta 2 2 4
MIRT079668 NAPG NSF attachment protein gamma 2 12
MIRT081651 CCNE1 cyclin E1 2 4
MIRT082996 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT083463 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT085755 RIF1 replication timing regulatory factor 1 2 2
MIRT086022 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087431 ZNRF3 zinc and ring finger 3 2 2
MIRT088786 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT089221 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT093696 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT095090 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT096249 CANX calnexin 2 2
MIRT100215 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT100746 VEGFA vascular endothelial growth factor A 2 12
MIRT100904 CD2AP CD2 associated protein 2 2
MIRT102647 UBN2 ubinuclein 2 2 10
MIRT103882 FOXK1 forkhead box K1 2 2
MIRT104246 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT106310 ZFHX4 zinc finger homeobox 4 2 6
MIRT107696 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT114943 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT117671 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT133799 SKI SKI proto-oncogene 2 2
MIRT140167 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT142279 DCTN5 dynactin subunit 5 2 8
MIRT143288 N4BP1 NEDD4 binding protein 1 2 2
MIRT165939 CREBRF CREB3 regulatory factor 2 2
MIRT175251 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT186381 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT191470 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT196480 TAOK1 TAO kinase 1 2 2
MIRT201470 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT204615 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204646 MOB4 MOB family member 4, phocein 2 8
MIRT204749 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT206031 NUP50 nucleoporin 50 2 6
MIRT211196 FGF2 fibroblast growth factor 2 2 4
MIRT229353 ZNF449 zinc finger protein 449 2 2
MIRT247138 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT249461 ZNF691 zinc finger protein 691 2 4
MIRT256314 CDC42SE2 CDC42 small effector 2 2 2
MIRT258419 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT265083 CHEK1 checkpoint kinase 1 2 2
MIRT270561 SETD1B SET domain containing 1B 2 2
MIRT274749 RAB3IP RAB3A interacting protein 2 2
MIRT277515 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT289642 CBX2 chromobox 2 2 2
MIRT301001 MTMR3 myotubularin related protein 3 2 2
MIRT307149 CTDSPL CTD small phosphatase like 2 4
MIRT309021 USP53 ubiquitin specific peptidase 53 2 2
MIRT314100 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT319338 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT320619 ZNRF2 zinc and ring finger 2 2 2
MIRT324285 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT446498 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT448437 TLL1 tolloid like 1 2 2
MIRT461537 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463162 ZNF367 zinc finger protein 367 2 10
MIRT463493 ZC3H10 zinc finger CCCH-type containing 10 2 2
MIRT465154 TSC22D2 TSC22 domain family member 2 2 2
MIRT466418 TFAP2A transcription factor AP-2 alpha 2 8
MIRT468278 SFT2D2 SFT2 domain containing 2 2 2
MIRT469399 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471941 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT473688 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT479618 CDC25A cell division cycle 25A 2 2
MIRT482098 AKT3 AKT serine/threonine kinase 3 2 4
MIRT483995 ATAD5 ATPase family, AAA domain containing 5 2 12
MIRT485205 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT498763 C3orf38 chromosome 3 open reading frame 38 2 8
MIRT498961 ORC4 origin recognition complex subunit 4 2 8
MIRT499440 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT500080 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500305 ZNF622 zinc finger protein 622 2 8
MIRT500410 ZMAT3 zinc finger matrin-type 3 2 8
MIRT500789 TLK1 tousled like kinase 1 2 6
MIRT500930 SRPR SRP receptor alpha subunit 2 6
MIRT500943 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501068 SMAD7 SMAD family member 7 2 8
MIRT501711 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT502627 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502910 CDCA4 cell division cycle associated 4 2 8
MIRT502935 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504531 ZNF620 zinc finger protein 620 2 6
MIRT505106 YTHDC1 YTH domain containing 1 2 6
MIRT505337 TMEM245 transmembrane protein 245 2 6
MIRT505383 TMEM100 transmembrane protein 100 2 2
MIRT505678 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT506157 PLAG1 PLAG1 zinc finger 2 8
MIRT506183 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506475 MYO5A myosin VA 2 6
MIRT506826 KIF23 kinesin family member 23 2 6
MIRT507160 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT507511 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT507845 CCNE2 cyclin E2 2 6
MIRT510403 ZNF507 zinc finger protein 507 2 2
MIRT518078 TRIM35 tripartite motif containing 35 2 2
MIRT518982 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT521045 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521190 SBNO1 strawberry notch homolog 1 2 6
MIRT522088 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT524846 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT527787 TMEM44 transmembrane protein 44 2 4
MIRT537803 EFNB2 ephrin B2 2 4
MIRT540830 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541140 PISD phosphatidylserine decarboxylase 2 2
MIRT541419 CBX4 chromobox 4 2 2
MIRT543517 PRSS21 protease, serine 21 2 2
MIRT543824 GSG1 germ cell associated 1 2 2
MIRT544959 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545179 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545335 CCDC83 coiled-coil domain containing 83 2 2
MIRT545518 RSL24D1 ribosomal L24 domain containing 1 2 2
MIRT545670 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545931 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546102 USP48 ubiquitin specific peptidase 48 2 4
MIRT546598 SALL1 spalt like transcription factor 1 2 4
MIRT546626 RTN4 reticulon 4 2 2
MIRT547651 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547987 HCFC2 host cell factor C2 2 4
MIRT548717 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548931 CDK17 cyclin dependent kinase 17 2 2
MIRT549067 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549266 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT550460 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550806 FAM229B family with sequence similarity 229 member B 2 2
MIRT552024 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552334 ZNF704 zinc finger protein 704 2 2
MIRT552732 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT553795 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554694 RNF149 ring finger protein 149 2 2
MIRT555133 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555264 PRDM4 PR/SET domain 4 2 2
MIRT556848 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557474 GPR27 G protein-coupled receptor 27 2 4
MIRT558018 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558498 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558579 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558610 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT558650 CNKSR3 CNKSR family member 3 2 2
MIRT558986 CA8 carbonic anhydrase 8 2 2
MIRT559141 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559327 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT562021 LANCL1 LanC like 1 2 2
MIRT562869 KIAA1456 KIAA1456 2 2
MIRT563074 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563496 DLGAP3 DLG associated protein 3 2 2
MIRT563890 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564311 CCNT1 cyclin T1 2 2
MIRT564942 XKR7 XK related 7 2 2
MIRT564979 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT565423 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566824 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT571961 KIF5B kinesin family member 5B 2 2
MIRT575877 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 3
MIRT576523 Txlna taxilin alpha 2 2
MIRT614693 TRAK1 trafficking kinesin protein 1 2 2
MIRT616065 ZC3H14 zinc finger CCCH-type containing 14 2 2
MIRT618838 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT624626 ATXN2 ataxin 2 2 2
MIRT624652 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT640314 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT659248 CUL3 cullin 3 2 2
MIRT680972 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682261 RS1 retinoschisin 1 2 2
MIRT682505 GLP2R glucagon like peptide 2 receptor 2 2
MIRT693904 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT699214 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT699373 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699451 SLC16A9 solute carrier family 16 member 9 2 2
MIRT701230 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT702849 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT706163 CASK calcium/calmodulin dependent serine protein kinase 2 3
MIRT718990 UTP15 UTP15, small subunit processome component 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4524a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4524a-5p Cetuximab resistant tissue (colorectal carcinoma)

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