miRTarBase - #MIRT541395


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pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CDC27   
Synonyms ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2
Description cell division cycle 27
Transcript NM_001114091   
Other Transcripts NM_001256   
Expression
Putative miRNA Targets on CDC27
3'UTR of CDC27
(miRNA target sites are highlighted)		 
>CDC27|NM_001114091|3'UTR
   1 CTTCTGGAAATCAGACTTTTACAACTGGATGTGTGACTAGTGCTGACGTGTTTCTTGTCCCTCTGTATACTGAGTCTTTA
  81 CTCTTGAGCTGGCGGTGTCATCGTCCGTCACTTATACCATGAGTGTGCCACTTTCATTGGACCCTGACTGTATACAGAAT
 161 GAAAGGCAGTGCAATATTTAGCTGCTAACAAGACTGGCTCTTTTACCAGTATGAATGACAATTTATGGGGGGTAGGGTGG
 241 GGAACTTTCTTTTCTGTTTTTCTTTAATCTCCCTTTGTTGGAAAGTATCATGAAAGGAAGAGTTATGCTTTATCTTGAAG
 321 GAACCATTAGATATGGAAAATAGTGATGAACCAGAGTTTCTTGGTTGCTTTTTCAAAAATTTGTTTTTATTTGGTTCTGT
 401 TCCTGATAAACAGAGTAACTGACCTTCATTTCTAGGTTCTTCAAGAATGGTGTTTGCAAGTGCCAGATGGAACAATAAAA
 481 GACGTTGCCTATAACAGTGACTTGATTGCCAAGGAATGTAAATTACCTTAAACTTGCAGTATCTCCCATAAACAAATGTA
 561 ATGGGCATATTGGGACTCGTATGTAGGAATCAAATATCCCTCCATACAGTGTACTCTTATTCTTGGCAAGAATGCTTTAA
 641 TGTCTAACCAAGAATTTTAATTTATTCATCTTGCTTCAAAGTGTTGATCATTGTTGTCTTGGTATTGCAAACTTTAAAAT
 721 TGTTTCTTACCATATTGCCTCTTCTCTTTGAGCTCTGTGGGATCACCTTTAACATTCAGAGATGATAGAGTGGTTCCCCA
 801 CTGAGAAGCCAAAACAAGGCCCTTAATAACCCCTTAAGTTCACCATATGAATCAGAAGGAGAACACTAAAGTGGAGAGAC
 881 TTTTAAGAGATCATGATAGTGAAAGCCTTAATATAATCAGAATTGTACCATAACCTTGAATCTATATTTGTTCAAAACAT
 961 CCCTTTGACTTTTCTAAGTGTTTGCTTAAGCAGAGTGTAAGAATGTGTGGTTACCTTTGGTTGAGATCCTTTCCATTCTT
1041 TTTGACTCTCTGCTTCAGATTTTTTCAGTAGTGTGAGTCACCAAAACATTTACTAAGAGTAATTGGGTTTAGGATGTTGG
1121 AAATTTTTAGCTTGGGGGAAAAAACATTCTTATGAAGGAGATAGGTTCTCTTCTGAGTTTGTCATAATATAGATTGGTGT
1201 CTTTGGAAAATGGCCACAATTTTAAGAATTCAATTATGCATATAAAATGATAATTATTGGAATTCCACAGTAACAGATTT
1281 AAACAGTCTTAAATTGTTTATCTCCTTTACTGTAATGTATTGAAATTTTTAGAGAAATTTTAGTTGTTAACATTTTATTA
1361 AGTGCCAGTGTCAGAATATAACAAATTATAGTTTCTTATGAATGACAGGCCTACAGTTATTATTCTGGATTATTTGATGG
1441 AGGACAAACTTACCTGTATTTGTTAGTCAAGCTGTGAAAATAAGGTGGATTACAAAAGATGTGAAAAAAATTTTAGTCTG
1521 TAGACTCAGTAATTTTCTATAATTTACTGTTAATCTCATTTGAACATGGATTAGGTACAATTTATAAATTAATTCAAGTC
1601 AGGGTCTTTAGGTATCAGGTGCCAGAGAGATATTTAACAGATTTCCCTACCTAAATTTATGTATATGTACTGTCTAAAAC
1681 AATACTTTTTTAAAAAAAAGGAACAGTTGGGAGAAAATAAATATAATGAAAAATTCCCAGAGGCTAGCACTTGGATTCTA
1761 ACACGTATGCTATTGTATTATCCATTAGTTCTGTAATATTTAATTTTAGATTCTTTTATTTTTTTAATTGGCAAAGCACA
1841 AGGTGCTGTATAACAGTGTCATTTAGAGTTTTATAGAAAGCTTCAACCTGAGTTCTGCGTTATAAAGCCTGGAGAAAGCT
1921 AAGCTTAGAACATAACTTGCTGAAGTATAATTATCTTTTTGTAGCAGGAATTTATGTGCCAGAGGTGAGAGTCTTTCTGG
2001 TACTGATTTTTTGAGACCAAGGATAAAAGGATCGTTTTGTAAGACATGCCATGGCAATGGCTGGTTGGGGGACAGTTTCC
2081 GCCCAAGCTTGGCCTATTTTATTTTTCCTCATACCTACTTTCAAAGTCATTTAGGTATTTGAAGCCTTATTTCCCACGTA
2161 GTAACACTTTCTGGCTTTTGCAGTTTCTTTTTTTGTTTGGTTTTGTTTTTTGCATGGAATGGGGATCAAACAACCCGAAG
2241 AAGAACACATTTTGATCAAGCAAAATGTTTGCTTCAAATTTCAGAAGTTTATTTTACAGAAATTAAATTAAGTAGTTTGA
2321 CATCCTTTTCTCTGTTTCACACATATATTAGGTTGGTGCATAAGTAATTGTGGTTTTTGCCATGACTTTTATGGCAAAAC
2401 CTGCAATTACTTTTGCACCAACTTAATACATCTATATACATATATATATACGCGCACACACTTGTTCAGAAGTTATGTTG
2481 TGGCCTTGGATTTGTTTTTCCCCTTGGAAATGGTTCTTAACTCTGGGATTTTAGAAGGTTAGAATATTTTTTCAAGAGAA
2561 CAGTGGTACTCAAAAGAATGAAAGGTGGTCCCTACATTTTCTGTATTCATCACTTAAAATTTTTAATTTTTCCGAGAACT
2641 ACAAGTAACATTTGAACCATGCTGCTGTTGTACCTTAAACAAAAACTCAGTGATAACCAGTATTTAGTCTATTAAAAATG
2721 CTCTTTTTGAAGAAAAAAGTTTGGAAGTCTCTGATTAGCCAGAGTATAGTATGAGTCTTCACTGAGAAATATGGTGACCC
2801 ATTTTCTTTGTGAAAACCTGGGAAAATGCAAGTGTGGGTATGAAGTGTGTGTTCTGTTTGCATTGAAACAATGTAATTTT
2881 GTGTCTTCTTTTTGCTTTAACTGACTTATTTCAGAAATTGTACAGTGTTGAGGGGGAAAGTCTTTTCTGTTAATATATTT
2961 GCAATTCATTAAAGGATATGGAAAATCCAAATAAGTTACTTTTGAAAGCAATTTATAATCAAGTTGTTAAAGCTATATGA
3041 AAGCTGTGCCATCTGTATTTTAATAAGAAGGCACAGAAAAACAGAGATACAGTTTTATGTTTCACAAAAAACTAGAGCAA
3121 TGTTTATCTAATTTTTTAAAACTTACACTCTTAATATATTTATATTTTTAAACGGTCATACTCTTTTTTAGTATTATTTG
3201 GAATATCAAAATAAATACTATGACAAAAACAATGGTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agauUGUGGU--GUCACACCAAAc 5'
              :||: |   | |||||||| 
Target 5' tggtGCATAAGTAATTGTGGTTTt 3'
 2354 - 2377 148.00 -10.50
2 
miRNA  3' agaUUGUGGUGUCACACCAAac 5'
             :| |: |:|| ||||||  
Target 5' tcaGAGATGATAGAGTGGTTcc 3'
 776 - 797 139.00 -11.90
3 
miRNA  3' agAUUGUGGUGUCACACCAAac 5'
            ||| |  |: ||||||||  
Target 5' tgTAAGA--AT-GTGTGGTTac 3'
 996 - 1014 135.00 -9.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30506039 4 COSMIC
COSN30132517 33 COSMIC
COSN31500513 57 COSMIC
COSN21838550 83 COSMIC
COSN32076875 86 COSMIC
COSN31513425 184 COSMIC
COSN26574233 197 COSMIC
COSN31518098 226 COSMIC
COSN24306124 316 COSMIC
COSN5417048 320 COSMIC
COSN6104915 350 COSMIC
COSN32153593 405 COSMIC
COSN31546908 481 COSMIC
COSN31543238 483 COSMIC
COSN1720470 491 COSMIC
COSN26636512 495 COSMIC
COSN32153592 504 COSMIC
COSN20234416 543 COSMIC
COSN20234415 545 COSMIC
COSN31487049 579 COSMIC
COSN31570031 652 COSMIC
COSN25429843 738 COSMIC
COSN20234414 797 COSMIC
COSN20236041 853 COSMIC
COSN20234413 918 COSMIC
COSN32093952 1025 COSMIC
COSN20236040 1028 COSMIC
COSN20235206 1033 COSMIC
COSN20235205 1079 COSMIC
COSN16154267 1112 COSMIC
COSN20235204 1231 COSMIC
COSN20239251 1305 COSMIC
COSN32153591 1317 COSMIC
COSN20238476 1372 COSMIC
COSN20239250 1395 COSMIC
COSN20240035 1537 COSMIC
COSN20236039 1557 COSMIC
COSN20238475 1674 COSMIC
COSN8242989 1692 COSMIC
COSN20238474 1884 COSMIC
COSN20234412 1993 COSMIC
COSN20236863 2107 COSMIC
COSN20234411 2128 COSMIC
COSN8674855 2216 COSMIC
COSN20240034 2227 COSMIC
COSN13727316 2257 COSMIC
COSN22097246 2319 COSMIC
COSN20240033 2332 COSMIC
COSN20234410 2338 COSMIC
COSN17182553 2406 COSMIC
COSN24306062 2427 COSMIC
COSN28201965 2439 COSMIC
COSN26507967 2451 COSMIC
COSN26556031 2569 COSMIC
COSN20236862 2571 COSMIC
COSN20237688 2806 COSMIC
COSN20239249 3020 COSMIC
rs11079757 2451 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1324988487 2 dbSNP
rs1157629240 17 dbSNP
rs754405109 18 dbSNP
rs1383225823 20 dbSNP
rs1387737589 21 dbSNP
rs1358424994 26 dbSNP
rs527713348 27 dbSNP
rs565155921 28 dbSNP
rs1427994195 31 dbSNP
rs551281316 34 dbSNP
rs1176633786 35 dbSNP
rs756905792 36 dbSNP
rs1371091311 38 dbSNP
rs1041076257 39 dbSNP
rs763841421 42 dbSNP
rs1445687860 43 dbSNP
rs1477392251 47 dbSNP
rs762760080 48 dbSNP
rs942468773 52 dbSNP
rs766303407 54 dbSNP
rs551713292 61 dbSNP
rs889537573 63 dbSNP
rs924288565 68 dbSNP
rs981152307 74 dbSNP
rs1207318975 75 dbSNP
rs1285385484 78 dbSNP
rs760482419 83 dbSNP
rs1042946253 93 dbSNP
rs947191825 94 dbSNP
rs9979 100 dbSNP
rs1186022721 102 dbSNP
rs913178300 103 dbSNP
rs1367429513 105 dbSNP
rs988747762 106 dbSNP
rs1177631090 107 dbSNP
rs1378038066 110 dbSNP
rs531715934 112 dbSNP
rs1433429792 115 dbSNP
rs971539793 123 dbSNP
rs1401207166 125 dbSNP
rs562997210 131 dbSNP
rs1338578929 133 dbSNP
rs1408389107 136 dbSNP
rs1453388179 137 dbSNP
rs186921791 141 dbSNP
rs1241419589 142 dbSNP
rs927987140 144 dbSNP
rs915695282 145 dbSNP
rs991615165 146 dbSNP
rs529040551 147 dbSNP
rs1199279249 149 dbSNP
rs1265473217 150 dbSNP
rs560046288 153 dbSNP
rs540160297 174 dbSNP
rs1197524668 185 dbSNP
rs375167684 185 dbSNP
rs1235828083 189 dbSNP
rs767542427 200 dbSNP
rs1027828024 221 dbSNP
rs577836582 222 dbSNP
rs1174290809 227 dbSNP
rs754105922 227 dbSNP
rs557476272 229 dbSNP
rs1465032219 230 dbSNP
rs1330808679 232 dbSNP
rs1163568414 233 dbSNP
rs143337546 233 dbSNP
rs1393385172 234 dbSNP
rs1023660502 238 dbSNP
rs142278808 242 dbSNP
rs962345662 247 dbSNP
rs984276816 249 dbSNP
rs575743684 254 dbSNP
rs1324973611 257 dbSNP
rs1218532717 259 dbSNP
rs889197848 263 dbSNP
rs952899675 268 dbSNP
rs1196020831 272 dbSNP
rs555752592 277 dbSNP
rs996650170 314 dbSNP
rs1449497586 321 dbSNP
rs892989399 324 dbSNP
rs1269291099 325 dbSNP
rs570612147 326 dbSNP
rs767315582 331 dbSNP
rs575289850 334 dbSNP
rs1463534893 354 dbSNP
rs901383194 372 dbSNP
rs1264614166 385 dbSNP
rs1390364553 390 dbSNP
rs1019316762 413 dbSNP
rs1403333369 418 dbSNP
rs1207508800 423 dbSNP
rs1311261505 426 dbSNP
rs1194149033 428 dbSNP
rs1296673536 432 dbSNP
rs555492278 460 dbSNP
rs775641781 461 dbSNP
rs924578786 465 dbSNP
rs769803542 467 dbSNP
rs536880298 479 dbSNP
rs375749345 483 dbSNP
rs1453453819 484 dbSNP
rs1356873674 491 dbSNP
rs1385165184 491 dbSNP
rs554377282 495 dbSNP
rs138180554 501 dbSNP
rs551971981 502 dbSNP
rs949783838 511 dbSNP
rs759772809 512 dbSNP
rs1042811359 514 dbSNP
rs947098466 518 dbSNP
rs1429036098 530 dbSNP
rs891649655 532 dbSNP
rs1465690217 537 dbSNP
rs11570575 556 dbSNP
rs991206310 557 dbSNP
rs1170845209 571 dbSNP
rs11570576 578 dbSNP
rs531722916 583 dbSNP
rs776793547 585 dbSNP
rs1287468295 593 dbSNP
rs1364777816 595 dbSNP
rs1187925323 603 dbSNP
rs920745826 606 dbSNP
rs1257583695 608 dbSNP
rs1311448260 617 dbSNP
rs1179626837 622 dbSNP
rs1482699170 642 dbSNP
rs1247759286 645 dbSNP
rs1251567023 653 dbSNP
rs1291971971 673 dbSNP
rs1352739023 681 dbSNP
rs1213453764 693 dbSNP
rs928532798 696 dbSNP
rs962601426 703 dbSNP
rs1242641475 704 dbSNP
rs371941195 706 dbSNP
rs1340555576 726 dbSNP
rs982160309 735 dbSNP
rs948044998 746 dbSNP
rs1157421802 765 dbSNP
rs1347295604 766 dbSNP
rs569289800 772 dbSNP
rs76387305 774 dbSNP
rs1362250132 786 dbSNP
rs1310617526 790 dbSNP
rs1454066337 796 dbSNP
rs1315127596 800 dbSNP
rs1375777762 800 dbSNP
rs1221686953 806 dbSNP
rs529321902 814 dbSNP
rs1308945757 819 dbSNP
rs1395565793 820 dbSNP
rs1209337640 823 dbSNP
rs1374301309 825 dbSNP
rs1261110520 826 dbSNP
rs559933325 827 dbSNP
rs1462582947 829 dbSNP
rs1019233637 830 dbSNP
rs1243789758 835 dbSNP
rs771110019 841 dbSNP
rs918762622 842 dbSNP
rs973303162 843 dbSNP
rs965696391 845 dbSNP
rs1411429881 848 dbSNP
rs1368401105 862 dbSNP
rs1175650524 880 dbSNP
rs1410664030 893 dbSNP
rs1419981425 906 dbSNP
rs1167744410 907 dbSNP
rs1471242629 916 dbSNP
rs1020266194 944 dbSNP
rs11570577 967 dbSNP
rs953704285 969 dbSNP
rs533076916 981 dbSNP
rs11570578 984 dbSNP
rs773435097 997 dbSNP
rs1011331383 999 dbSNP
rs1281132881 1000 dbSNP
rs11570579 1005 dbSNP
rs141572435 1007 dbSNP
rs1306948260 1016 dbSNP
rs1052999428 1017 dbSNP
rs1202701226 1027 dbSNP
rs1003102592 1042 dbSNP
rs182180178 1046 dbSNP
rs1250778734 1071 dbSNP
rs748538860 1077 dbSNP
rs1199231252 1083 dbSNP
rs1267179459 1084 dbSNP
rs778580407 1092 dbSNP
rs1481870575 1093 dbSNP
rs1251487539 1097 dbSNP
rs998731052 1099 dbSNP
rs754489921 1116 dbSNP
rs1362182436 1120 dbSNP
rs1264253448 1125 dbSNP
rs1435271402 1132 dbSNP
rs1044720813 1135 dbSNP
rs748983028 1140 dbSNP
rs948616375 1141 dbSNP
rs1309248365 1142 dbSNP
rs894158133 1144 dbSNP
rs1212943040 1145 dbSNP
rs541966797 1152 dbSNP
rs1055445715 1153 dbSNP
rs916584494 1160 dbSNP
rs1350121634 1161 dbSNP
rs1290076024 1162 dbSNP
rs1490932230 1168 dbSNP
rs1307133620 1171 dbSNP
rs930383172 1177 dbSNP
rs1048348706 1184 dbSNP
rs34022421 1196 dbSNP
rs1187799850 1226 dbSNP
rs972203381 1227 dbSNP
rs1423630606 1228 dbSNP
rs550261915 1233 dbSNP
rs1367212823 1236 dbSNP
rs192792234 1238 dbSNP
rs912098703 1246 dbSNP
rs1456964527 1247 dbSNP
rs1317360486 1257 dbSNP
rs987756617 1266 dbSNP
rs370562787 1269 dbSNP
rs71375392 1295 dbSNP
rs953481404 1298 dbSNP
rs931431009 1302 dbSNP
rs1028981793 1311 dbSNP
rs1245567648 1315 dbSNP
rs554411835 1316 dbSNP
rs1313107964 1322 dbSNP
rs534402159 1324 dbSNP
rs958099944 1330 dbSNP
rs753652718 1341 dbSNP
rs780059853 1344 dbSNP
rs1218498142 1353 dbSNP
rs1242223435 1359 dbSNP
rs1443405194 1370 dbSNP
rs1031129762 1379 dbSNP
rs1200574365 1388 dbSNP
rs1453747166 1398 dbSNP
rs1444861731 1408 dbSNP
rs755815361 1409 dbSNP
rs1382486615 1411 dbSNP
rs1402402691 1413 dbSNP
rs1265883288 1420 dbSNP
rs779896547 1437 dbSNP
rs571887387 1443 dbSNP
rs1452078425 1444 dbSNP
rs1334778734 1445 dbSNP
rs1385308917 1453 dbSNP
rs965914851 1455 dbSNP
rs188219399 1459 dbSNP
rs1245760844 1466 dbSNP
rs1270043458 1473 dbSNP
rs903024918 1475 dbSNP
rs1348934495 1477 dbSNP
rs1225977160 1480 dbSNP
rs912700053 1482 dbSNP
rs1285496298 1484 dbSNP
rs1206934392 1490 dbSNP
rs1201304580 1499 dbSNP
rs986133018 1500 dbSNP
rs1244414532 1512 dbSNP
rs917466591 1514 dbSNP
rs1461529774 1515 dbSNP
rs1328710334 1516 dbSNP
rs954236546 1538 dbSNP
rs1021306470 1539 dbSNP
rs1223881097 1549 dbSNP
rs12941737 1550 dbSNP
rs1490478992 1553 dbSNP
rs1011246509 1573 dbSNP
rs1159091034 1589 dbSNP
rs1014189560 1595 dbSNP
rs183461305 1597 dbSNP
rs955800202 1598 dbSNP
rs1468136094 1604 dbSNP
rs1334845979 1614 dbSNP
rs568935180 1615 dbSNP
rs569818316 1618 dbSNP
rs548934011 1626 dbSNP
rs1408323190 1639 dbSNP
rs11570580 1644 dbSNP
rs1328358994 1645 dbSNP
rs1334365378 1659 dbSNP
rs1444889477 1664 dbSNP
rs1385620846 1665 dbSNP
rs1323500908 1668 dbSNP
rs1222199026 1677 dbSNP
rs1002599260 1691 dbSNP
rs11570581 1692 dbSNP
rs930351874 1692 dbSNP
rs1044198415 1700 dbSNP
rs1247913801 1700 dbSNP
rs1387437946 1704 dbSNP
rs1267886316 1710 dbSNP
rs1479426622 1711 dbSNP
rs1036123341 1723 dbSNP
rs1302478333 1738 dbSNP
rs1176798096 1742 dbSNP
rs1466562508 1749 dbSNP
rs112543578 1764 dbSNP
rs561513070 1765 dbSNP
rs1411838341 1773 dbSNP
rs1048420504 1800 dbSNP
rs1309071694 1811 dbSNP
rs150229852 1820 dbSNP
rs1403675689 1826 dbSNP
rs1429583579 1843 dbSNP
rs1331195239 1847 dbSNP
rs932206857 1848 dbSNP
rs1341094732 1849 dbSNP
rs1205362788 1855 dbSNP
rs922212292 1857 dbSNP
rs11570582 1867 dbSNP
rs1489763208 1867 dbSNP
rs958024922 1886 dbSNP
rs1427847331 1891 dbSNP
rs923988171 1892 dbSNP
rs1371384810 1898 dbSNP
rs530687329 1899 dbSNP
rs1169427446 1906 dbSNP
rs1365350144 1909 dbSNP
rs1423069247 1913 dbSNP
rs11570583 1918 dbSNP
rs187824241 1930 dbSNP
rs541800959 1936 dbSNP
rs1344023351 1943 dbSNP
rs967591150 1961 dbSNP
rs540193399 1963 dbSNP
rs559535799 1971 dbSNP
rs559481223 1985 dbSNP
rs1327632298 1988 dbSNP
rs540504663 1993 dbSNP
rs1228686273 2017 dbSNP
rs548047355 2020 dbSNP
rs1014539280 2027 dbSNP
rs1356803992 2031 dbSNP
rs1224531163 2032 dbSNP
rs912723503 2033 dbSNP
rs1034232696 2034 dbSNP
rs1343151618 2052 dbSNP
rs1253974922 2055 dbSNP
rs994428774 2064 dbSNP
rs578110101 2065 dbSNP
rs528097088 2067 dbSNP
rs1259782492 2071 dbSNP
rs115831653 2080 dbSNP
rs140967083 2081 dbSNP
rs914811092 2084 dbSNP
rs1004619478 2087 dbSNP
rs1369361186 2098 dbSNP
rs1453708811 2108 dbSNP
rs1363746535 2110 dbSNP
rs1713494 2111 dbSNP
rs1435257507 2115 dbSNP
rs1335488923 2116 dbSNP
rs1380176522 2122 dbSNP
rs1247690518 2123 dbSNP
rs1415776785 2129 dbSNP
rs955912559 2131 dbSNP
rs1399657462 2136 dbSNP
rs1031313221 2139 dbSNP
rs369577736 2150 dbSNP
rs11570584 2157 dbSNP
rs759652195 2158 dbSNP
rs1023254946 2162 dbSNP
rs1012701115 2169 dbSNP
rs1243761604 2183 dbSNP
rs776668817 2200 dbSNP
rs766644276 2208 dbSNP
rs1027515439 2213 dbSNP
rs1183773313 2214 dbSNP
rs1414977639 2219 dbSNP
rs1418803577 2222 dbSNP
rs760805313 2223 dbSNP
rs1157357281 2227 dbSNP
rs1366123782 2229 dbSNP
rs151090024 2236 dbSNP
rs1440879574 2237 dbSNP
rs1403208207 2246 dbSNP
rs765714462 2246 dbSNP
rs776334668 2248 dbSNP
rs993344669 2254 dbSNP
rs1303000245 2255 dbSNP
rs144370733 2262 dbSNP
rs1389521418 2279 dbSNP
rs1308880008 2283 dbSNP
rs1036994095 2296 dbSNP
rs1222766521 2307 dbSNP
rs11570585 2312 dbSNP
rs200959496 2312 dbSNP
rs958540254 2315 dbSNP
rs1034203274 2317 dbSNP
rs1238324651 2320 dbSNP
rs1480426306 2326 dbSNP
rs1175889512 2332 dbSNP
rs773632212 2345 dbSNP
rs944126668 2346 dbSNP
rs1199282030 2352 dbSNP
rs1014580682 2355 dbSNP
rs891200495 2359 dbSNP
rs1226012516 2360 dbSNP
rs1176142217 2363 dbSNP
rs879094621 2367 dbSNP
rs112979490 2371 dbSNP
rs1460127382 2373 dbSNP
rs11570586 2374 dbSNP
rs890207730 2382 dbSNP
rs932795527 2387 dbSNP
rs1281234603 2390 dbSNP
rs1347307132 2392 dbSNP
rs534205473 2403 dbSNP
rs1051951000 2411 dbSNP
rs914716306 2413 dbSNP
rs1221079473 2430 dbSNP
rs990420214 2432 dbSNP
rs996309412 2436 dbSNP
rs1202636483 2440 dbSNP
rs1277252154 2443 dbSNP
rs1449630784 2446 dbSNP
rs11079757 2451 dbSNP
rs900684376 2451 dbSNP
rs936888132 2452 dbSNP
rs924280249 2453 dbSNP
rs981122837 2454 dbSNP
rs1426396531 2456 dbSNP
rs1170019567 2462 dbSNP
rs1372723575 2472 dbSNP
rs11570587 2476 dbSNP
rs1301058773 2477 dbSNP
rs11570588 2480 dbSNP
rs1437079930 2483 dbSNP
rs949417989 2489 dbSNP
rs991310729 2495 dbSNP
rs1361311028 2500 dbSNP
rs879175515 2508 dbSNP
rs1027420550 2510 dbSNP
rs1213034634 2521 dbSNP
rs993377017 2536 dbSNP
rs1300024358 2537 dbSNP
rs1343126576 2539 dbSNP
rs917974138 2555 dbSNP
rs1453888605 2571 dbSNP
rs1222896300 2576 dbSNP
rs897705499 2580 dbSNP
rs774333766 2586 dbSNP
rs561962378 2589 dbSNP
rs1165055841 2590 dbSNP
rs1016043006 2591 dbSNP
rs1008212604 2596 dbSNP
rs927113247 2603 dbSNP
rs973239856 2608 dbSNP
rs1182718984 2615 dbSNP
rs891237022 2621 dbSNP
rs556842651 2624 dbSNP
rs1322642809 2629 dbSNP
rs1245495811 2633 dbSNP
rs1313409565 2636 dbSNP
rs368935549 2640 dbSNP
rs1229404748 2643 dbSNP
rs1284245903 2644 dbSNP
rs1315651263 2645 dbSNP
rs548249638 2649 dbSNP
rs1202805804 2658 dbSNP
rs983098488 2662 dbSNP
rs1482671917 2666 dbSNP
rs1460614246 2672 dbSNP
rs1181327047 2675 dbSNP
rs1238993472 2676 dbSNP
rs954532309 2677 dbSNP
rs1030050649 2687 dbSNP
rs544356957 2695 dbSNP
rs1458723116 2707 dbSNP
rs1353725409 2709 dbSNP
rs900276803 2720 dbSNP
rs1452191996 2721 dbSNP
rs1032498313 2722 dbSNP
rs1001066854 2728 dbSNP
rs893312539 2737 dbSNP
rs1449298568 2739 dbSNP
rs1279304199 2759 dbSNP
rs1349219168 2763 dbSNP
rs1230722632 2765 dbSNP
rs1268246716 2791 dbSNP
rs1322128917 2792 dbSNP
rs1201402490 2793 dbSNP
rs1280372804 2799 dbSNP
rs1442640258 2810 dbSNP
rs1180875393 2821 dbSNP
rs748858516 2837 dbSNP
rs1043040168 2842 dbSNP
rs1182768348 2849 dbSNP
rs1412807616 2856 dbSNP
rs934942845 2866 dbSNP
rs183415078 2870 dbSNP
rs1170887456 2881 dbSNP
rs1404667402 2881 dbSNP
rs1306516378 2889 dbSNP
rs1415232076 2891 dbSNP
rs1409642192 2895 dbSNP
rs1328627018 2908 dbSNP
rs1348972540 2932 dbSNP
rs1412227106 2937 dbSNP
rs1289462039 2940 dbSNP
rs1345420702 2942 dbSNP
rs896499068 2962 dbSNP
rs1055075141 2964 dbSNP
rs73985136 2974 dbSNP
rs1326194535 2977 dbSNP
rs1194830746 2985 dbSNP
rs938086033 2997 dbSNP
rs559212170 3011 dbSNP
rs1483878673 3022 dbSNP
rs920046994 3032 dbSNP
rs1404102731 3033 dbSNP
rs973205844 3036 dbSNP
rs1196908916 3043 dbSNP
rs1413095355 3044 dbSNP
rs1478496822 3049 dbSNP
rs1167488548 3054 dbSNP
rs76564584 3068 dbSNP
rs1473675218 3071 dbSNP
rs1432079164 3081 dbSNP
rs879541860 3088 dbSNP
rs749384405 3092 dbSNP
rs576831797 3098 dbSNP
rs907748246 3099 dbSNP
rs779700421 3102 dbSNP
rs564714667 3107 dbSNP
rs954378995 3112 dbSNP
rs185259037 3115 dbSNP
rs574111157 3120 dbSNP
rs1295015523 3130 dbSNP
rs951757540 3137 dbSNP
rs964448549 3142 dbSNP
rs920434930 3147 dbSNP
rs555593124 3153 dbSNP
rs1223585910 3158 dbSNP
rs1211522309 3173 dbSNP
rs1001007702 3174 dbSNP
rs755792256 3178 dbSNP
rs902694787 3182 dbSNP
rs1192545937 3191 dbSNP
rs1388623777 3193 dbSNP
rs1451527059 3206 dbSNP
rs534166769 3207 dbSNP
rs566529115 3217 dbSNP
rs781059013 3220 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 996.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714646. RNA binding protein: AGO2. Condition:mildMNase "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agauuguggugUCACACCAAAc 5'
                     | |||||||| 
Target 5' ----auaaguaAUUGUGGUUUu 3'
 		1 - 18
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714646
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repA
Location of target site ENST00000066544.3 | 3UTR | CAUAAGUAAUUGUGGUUUUUGCCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000066544.3 | 3UTR | AUAAGUAAUUGUGGUUUUUGCCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.669 1.8e-4 -0.723 3.3e-5 24 Click to see details
GSE28260 Renal cortex and medulla 0.73 2.3e-3 0.691 4.5e-3 13 Click to see details
GSE17498 Multiple myeloma -0.269 4.7e-2 -0.311 2.5e-2 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.232 1.6e-1 -0.057 4.1e-1 20 Click to see details
GSE38226 Liver fibrosis 0.225 1.6e-1 0.306 8.9e-2 21 Click to see details
GSE19350 CNS germ cell tumors -0.296 1.8e-1 0.077 4.1e-1 12 Click to see details
GSE21687 Ependynoma primary tumors -0.107 2.0e-1 -0.122 1.7e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.122 2.8e-1 0.297 7.5e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.109 3.1e-1 0.077 3.6e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.042 4.1e-1 -0.169 1.8e-1 32 Click to see details
GSE32688 Pancreatic cancer -0.042 4.1e-1 -0.169 1.8e-1 32 Click to see details
GSE32688 Pancreatic cancer -0.042 4.1e-1 -0.169 1.8e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUAD 0.994 0 1.000 0.5 4 Click to see details
THCA 0.162 0.14 0.181 0.12 45 Click to see details
UCEC 0.281 0.15 0.412 0.06 16 Click to see details
KIRP 0.195 0.2 0.216 0.17 21 Click to see details
BLCA -0.552 0.22 -0.400 0.3 4 Click to see details
LIHC -0.143 0.23 -0.119 0.27 30 Click to see details
PRAD -0.109 0.24 -0.193 0.1 46 Click to see details
STAD -0.159 0.25 -0.260 0.13 21 Click to see details
ESCA 0.194 0.3 -0.176 0.31 10 Click to see details
CHOL -0.218 0.34 -0.429 0.2 6 Click to see details
KICH -0.09 0.37 0.007 0.49 15 Click to see details
HNSC -0.072 0.39 0.055 0.41 18 Click to see details
LUSC -0.03 0.44 0.010 0.48 30 Click to see details
PAAD -0.106 0.45 0.200 0.4 4 Click to see details
KIRC -0.004 0.49 0.000 0.5 43 Click to see details
BRCA -0.001 0.5 0.025 0.44 42 Click to see details
BRCA -0.001 0.5 0.025 0.44 42 Click to see details
BRCA -0.001 0.5 0.025 0.44 42 Click to see details
BRCA -0.001 0.5 0.025 0.44 42 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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