pre-miRNA Information
pre-miRNA hsa-mir-4524a   
Genomic Coordinates chr17: 69099564 - 69099632
Description Homo sapiens miR-4524a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524a-5p
Sequence 6| AUAGCAGCAUGAACCUGUCUCA |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322445998 8 dbSNP
rs1350790266 13 dbSNP
rs1263495678 21 dbSNP
Putative Targets

Gene Information
Gene Symbol CBX4   
Synonyms NBP16, PC2
Description chromobox 4
Transcript NM_003655   
Expression
Putative miRNA Targets on CBX4
3'UTR of CBX4
(miRNA target sites are highlighted)
>CBX4|NM_003655|3'UTR
   1 CCGGAGGGCGTCGGAAGGGGAAGCGCCATTCCCGCGGGGGGGCGGGGAGCTGAGCACCTGGGGCCTCGGGGCGGGCTCCC
  81 CTCTCGCCAACCCGCCAACCGCGAGAGACCCAGGCTGGCCCCCAGGGTGAGGACGCCCGGAGCGGAGGTAACCATGTTCC
 161 CCCTGCGGCGGCTGTCAGACCTGGGCGGAGGCCCCTTCCACGCGGTGCCGGCGGGGCTCGCCCTCTCCTGCCCTTCCCCG
 241 CTGGAGATGGACCCCCGGAACGGACAGGGCAGCTCTGCGCCCGGCCTCAGAGTTCTAGTATTATATTTTAACCGTGCTAA
 321 CTTGTCAAGTGCTGACTCTACTCCCGTTTGTACGTGGTGTTATTATTGAAATGTATTGTTTGAGCTCAAAAGGCCCGACC
 401 ACCCCCCTTCGGGCTGCTATATATATATTTATTTGTAGGTATTTATATATTGAAATATAAAAACCTAGATTTATGGAGTT
 481 TCCTCTAGATCATGTTATATTCTATATCAGACAAACTATTTTCTTTTGACCTTTCTTCCCCTCCATCCAGTATTTCGGTT
 561 GATTTCATTTTCTCCCCTCTCTTCCCCTTCCACGAACTGCAATACCAGTAACCTTGGTATATATTTTTTGATACTGTACA
 641 CATGGATGTCTTGTTTCTATGTGCAAAAAAAAAAAAAAAAAAAAGTTTGTTAAAAGGCTACACGAGCTCTCTAGAAACTG
 721 CTGCTACTAGAAATGTCTAAACTATAAGCTTCCAACTATTACCTGCTTGAATGTAAATATTAAATGGAGATGTTGAAGGT
 801 GCAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acucuguccAAGUACGACGAUa 5'
                   |||: ||||||| 
Target 5' ccaccccccTTCGGGCTGCTAt 3'
399 - 420 153.00 -13.30
2
miRNA  3' acucuguccaaguACGACGAUa 5'
                       |||||||| 
Target 5' gctctctagaaacTGCTGCTAc 3'
706 - 727 145.00 -9.50
3
miRNA  3' acUCUGUCCA-AGUACGACGAUa 5'
            | |::| | || ||:| ||| 
Target 5' acACATGGATGTCTTGTTTCTAt 3'
638 - 660 112.00 -7.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13752156 9 COSMIC
COSN17182773 13 COSMIC
COSN26576158 24 COSMIC
COSN30187328 34 COSMIC
COSN30138771 35 COSMIC
COSN30520297 38 COSMIC
COSN30147562 68 COSMIC
COSN26969327 73 COSMIC
COSN30147640 83 COSMIC
COSN31531605 100 COSMIC
COSN31596846 201 COSMIC
COSN31568636 417 COSMIC
COSN30544642 503 COSMIC
COSN30172826 579 COSMIC
COSN31488023 624 COSMIC
COSN31555932 655 COSMIC
COSN29737575 664 COSMIC
COSN26509531 693 COSMIC
COSN26574629 730 COSMIC
COSN31518155 735 COSMIC
COSN26649517 742 COSMIC
COSN27998536 763 COSMIC
COSN31583954 771 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1250517739 2 dbSNP
rs759489445 9 dbSNP
rs771033233 10 dbSNP
rs969000696 12 dbSNP
rs1434243265 13 dbSNP
rs749310461 14 dbSNP
rs773577839 22 dbSNP
rs770089482 23 dbSNP
rs748551572 24 dbSNP
rs781587836 31 dbSNP
rs545813747 33 dbSNP
rs747536556 36 dbSNP
rs774520158 36 dbSNP
rs778352766 37 dbSNP
rs144757374 38 dbSNP
rs541674947 41 dbSNP
rs200238347 42 dbSNP
rs749454180 43 dbSNP
rs752531500 43 dbSNP
rs771147949 43 dbSNP
rs767323954 44 dbSNP
rs1222283506 46 dbSNP
rs1322212056 47 dbSNP
rs1278200622 48 dbSNP
rs996569274 49 dbSNP
rs377592612 50 dbSNP
rs900524567 52 dbSNP
rs1202932478 56 dbSNP
rs1251116964 58 dbSNP
rs948770975 60 dbSNP
rs1428900705 68 dbSNP
rs1040796552 70 dbSNP
rs1480180459 71 dbSNP
rs867027777 72 dbSNP
rs1408416036 75 dbSNP
rs1169935973 80 dbSNP
rs1350259357 82 dbSNP
rs886535448 86 dbSNP
rs1301270329 91 dbSNP
rs1460784070 94 dbSNP
rs924885077 99 dbSNP
rs977671141 101 dbSNP
rs1359177319 109 dbSNP
rs1047848880 125 dbSNP
rs866315866 130 dbSNP
rs914713991 133 dbSNP
rs975573572 135 dbSNP
rs963828967 138 dbSNP
rs555880348 139 dbSNP
rs1019358082 148 dbSNP
rs1490329400 159 dbSNP
rs1217513304 161 dbSNP
rs1243933932 162 dbSNP
rs1228359545 164 dbSNP
rs1474429858 164 dbSNP
rs543616093 168 dbSNP
rs1446265263 169 dbSNP
rs1161436809 176 dbSNP
rs1364946335 181 dbSNP
rs1309659795 183 dbSNP
rs899402661 187 dbSNP
rs1245942297 189 dbSNP
rs1044679739 201 dbSNP
rs769503411 202 dbSNP
rs180834650 203 dbSNP
rs916897286 209 dbSNP
rs1380853160 214 dbSNP
rs1336885954 219 dbSNP
rs992506882 220 dbSNP
rs1359099826 222 dbSNP
rs1045184900 224 dbSNP
rs934364653 233 dbSNP
rs1012468134 234 dbSNP
rs1393608801 242 dbSNP
rs978588232 244 dbSNP
rs1012031571 247 dbSNP
rs1462814337 248 dbSNP
rs1372210804 253 dbSNP
rs968611252 254 dbSNP
rs1161404851 258 dbSNP
rs1443984303 261 dbSNP
rs1399659824 270 dbSNP
rs1407923126 282 dbSNP
rs1450032585 283 dbSNP
rs894586871 284 dbSNP
rs1057129096 285 dbSNP
rs938693783 287 dbSNP
rs1281821015 288 dbSNP
rs563505896 299 dbSNP
rs1028641575 304 dbSNP
rs557875947 312 dbSNP
rs1223346564 313 dbSNP
rs1279436900 314 dbSNP
rs965688657 322 dbSNP
rs1202038382 323 dbSNP
rs1242705774 327 dbSNP
rs375307412 331 dbSNP
rs1458082687 336 dbSNP
rs1183686420 338 dbSNP
rs753845952 339 dbSNP
rs1249850761 340 dbSNP
rs1196637805 341 dbSNP
rs1018869129 342 dbSNP
rs1467740020 343 dbSNP
rs1175296147 346 dbSNP
rs1008858898 349 dbSNP
rs539434068 356 dbSNP
rs914827422 362 dbSNP
rs1331275998 365 dbSNP
rs1334290465 368 dbSNP
rs1442119486 373 dbSNP
rs1284437884 377 dbSNP
rs975604363 393 dbSNP
rs942834301 399 dbSNP
rs1262800465 402 dbSNP
rs1286475280 403 dbSNP
rs1197402079 404 dbSNP
rs1270643534 405 dbSNP
rs370541889 406 dbSNP
rs34112818 408 dbSNP
rs1199529958 414 dbSNP
rs912328295 416 dbSNP
rs546203024 429 dbSNP
rs566033439 436 dbSNP
rs1423965693 447 dbSNP
rs1463211653 456 dbSNP
rs1165726127 458 dbSNP
rs1391652481 459 dbSNP
rs553903002 476 dbSNP
rs1044974508 482 dbSNP
rs948967860 487 dbSNP
rs896063822 508 dbSNP
rs1301122251 517 dbSNP
rs1403257750 522 dbSNP
rs1025275471 523 dbSNP
rs1423758622 523 dbSNP
rs1056778752 531 dbSNP
rs1268597783 539 dbSNP
rs934353113 541 dbSNP
rs1222926888 545 dbSNP
rs1293945656 549 dbSNP
rs1489835091 552 dbSNP
rs1164958993 558 dbSNP
rs924348182 559 dbSNP
rs1429729048 583 dbSNP
rs745734663 592 dbSNP
rs867287159 593 dbSNP
rs1372118140 594 dbSNP
rs766178345 597 dbSNP
rs535697117 602 dbSNP
rs1475313371 613 dbSNP
rs188739176 634 dbSNP
rs1368073183 649 dbSNP
rs1423312438 653 dbSNP
rs1385804002 659 dbSNP
rs1383946808 661 dbSNP
rs1363342745 663 dbSNP
rs1182594385 664 dbSNP
rs1473729958 665 dbSNP
rs1267035929 666 dbSNP
rs1316907232 666 dbSNP
rs1356923146 669 dbSNP
rs1245189778 671 dbSNP
rs1261185749 672 dbSNP
rs1486587766 679 dbSNP
rs1202819533 681 dbSNP
rs975662213 682 dbSNP
rs965287536 683 dbSNP
rs63707360 684 dbSNP
rs11350225 685 dbSNP
rs1163531842 685 dbSNP
rs1364859399 685 dbSNP
rs1380332959 685 dbSNP
rs1387481825 685 dbSNP
rs1418152619 685 dbSNP
rs1443126766 685 dbSNP
rs1453661952 685 dbSNP
rs398031721 685 dbSNP
rs547077489 685 dbSNP
rs763341560 685 dbSNP
rs767454528 685 dbSNP
rs775496280 685 dbSNP
rs879214086 685 dbSNP
rs1451611024 686 dbSNP
rs1490619642 688 dbSNP
rs1307663327 689 dbSNP
rs1318648965 689 dbSNP
rs896731200 689 dbSNP
rs1292407789 696 dbSNP
rs549991920 697 dbSNP
rs1350551120 700 dbSNP
rs555754057 703 dbSNP
rs1460299318 708 dbSNP
rs1181609148 739 dbSNP
rs1251956087 743 dbSNP
rs1421411057 744 dbSNP
rs1259680558 756 dbSNP
rs1002918613 762 dbSNP
rs903260830 763 dbSNP
rs747289977 766 dbSNP
rs1352016183 767 dbSNP
rs1404140083 768 dbSNP
rs531584902 769 dbSNP
rs781116914 774 dbSNP
rs568409912 786 dbSNP
rs1298519037 789 dbSNP
rs1403904756 791 dbSNP
rs183813110 793 dbSNP
rs1345951244 795 dbSNP
rs1325250115 803 dbSNP
rs58174557 804 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 8535.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acucuguccaaguACGACGAUa 5'
                       |||||||| 
Target 5' gcucucuagaaacUGCUGCUAc 3'
17 - 38
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760597. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000269397.4 | 3UTR | UUAAAAGGCUACACGAGCUCUCUAGAAACUGCUGCUACUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
180 hsa-miR-4524a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055251 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT055826 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT060573 CCND1 cyclin D1 2 2
MIRT061013 C1ORF21 chromosome 1 open reading frame 21 2 6
MIRT064694 CCND2 cyclin D2 2 4
MIRT075268 SNTB2 syntrophin beta 2 2 4
MIRT079668 NAPG NSF attachment protein gamma 2 12
MIRT081651 CCNE1 cyclin E1 2 4
MIRT082996 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT083463 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT085755 RIF1 replication timing regulatory factor 1 2 2
MIRT086022 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087431 ZNRF3 zinc and ring finger 3 2 2
MIRT088786 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT089221 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT093696 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT095090 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT096249 CANX calnexin 2 2
MIRT100215 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT100746 VEGFA vascular endothelial growth factor A 2 12
MIRT100904 CD2AP CD2 associated protein 2 2
MIRT102647 UBN2 ubinuclein 2 2 10
MIRT103882 FOXK1 forkhead box K1 2 2
MIRT104246 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT106310 ZFHX4 zinc finger homeobox 4 2 6
MIRT107696 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT114943 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT117671 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT133799 SKI SKI proto-oncogene 2 2
MIRT140167 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT142279 DCTN5 dynactin subunit 5 2 8
MIRT143288 N4BP1 NEDD4 binding protein 1 2 2
MIRT165939 CREBRF CREB3 regulatory factor 2 2
MIRT175251 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT186381 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT191470 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT196480 TAOK1 TAO kinase 1 2 2
MIRT201470 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT204615 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204646 MOB4 MOB family member 4, phocein 2 8
MIRT204749 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT206031 NUP50 nucleoporin 50 2 6
MIRT211196 FGF2 fibroblast growth factor 2 2 4
MIRT229353 ZNF449 zinc finger protein 449 2 2
MIRT247138 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT249461 ZNF691 zinc finger protein 691 2 4
MIRT256314 CDC42SE2 CDC42 small effector 2 2 2
MIRT258419 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT265083 CHEK1 checkpoint kinase 1 2 2
MIRT270561 SETD1B SET domain containing 1B 2 2
MIRT274749 RAB3IP RAB3A interacting protein 2 2
MIRT277515 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT289642 CBX2 chromobox 2 2 2
MIRT301001 MTMR3 myotubularin related protein 3 2 2
MIRT307149 CTDSPL CTD small phosphatase like 2 4
MIRT309021 USP53 ubiquitin specific peptidase 53 2 2
MIRT314100 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT319338 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT320619 ZNRF2 zinc and ring finger 2 2 2
MIRT324285 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT446498 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT448437 TLL1 tolloid like 1 2 2
MIRT461537 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463162 ZNF367 zinc finger protein 367 2 10
MIRT463493 ZC3H10 zinc finger CCCH-type containing 10 2 2
MIRT465154 TSC22D2 TSC22 domain family member 2 2 2
MIRT466418 TFAP2A transcription factor AP-2 alpha 2 8
MIRT468278 SFT2D2 SFT2 domain containing 2 2 2
MIRT469399 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471941 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT473688 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT479618 CDC25A cell division cycle 25A 2 2
MIRT482098 AKT3 AKT serine/threonine kinase 3 2 4
MIRT483995 ATAD5 ATPase family, AAA domain containing 5 2 12
MIRT485205 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT498763 C3orf38 chromosome 3 open reading frame 38 2 8
MIRT498961 ORC4 origin recognition complex subunit 4 2 8
MIRT499440 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT500080 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500305 ZNF622 zinc finger protein 622 2 8
MIRT500410 ZMAT3 zinc finger matrin-type 3 2 8
MIRT500789 TLK1 tousled like kinase 1 2 6
MIRT500930 SRPR SRP receptor alpha subunit 2 6
MIRT500943 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501068 SMAD7 SMAD family member 7 2 8
MIRT501711 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT502627 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502910 CDCA4 cell division cycle associated 4 2 8
MIRT502935 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504531 ZNF620 zinc finger protein 620 2 6
MIRT505106 YTHDC1 YTH domain containing 1 2 6
MIRT505337 TMEM245 transmembrane protein 245 2 6
MIRT505383 TMEM100 transmembrane protein 100 2 2
MIRT505678 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT506157 PLAG1 PLAG1 zinc finger 2 8
MIRT506183 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506475 MYO5A myosin VA 2 6
MIRT506826 KIF23 kinesin family member 23 2 6
MIRT507160 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT507511 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT507845 CCNE2 cyclin E2 2 6
MIRT510403 ZNF507 zinc finger protein 507 2 2
MIRT518078 TRIM35 tripartite motif containing 35 2 2
MIRT518982 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT521045 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521190 SBNO1 strawberry notch homolog 1 2 6
MIRT522088 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT524846 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT527787 TMEM44 transmembrane protein 44 2 4
MIRT537803 EFNB2 ephrin B2 2 4
MIRT540830 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541140 PISD phosphatidylserine decarboxylase 2 2
MIRT541419 CBX4 chromobox 4 2 2
MIRT543517 PRSS21 protease, serine 21 2 2
MIRT543824 GSG1 germ cell associated 1 2 2
MIRT544959 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545179 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545335 CCDC83 coiled-coil domain containing 83 2 2
MIRT545518 RSL24D1 ribosomal L24 domain containing 1 2 2
MIRT545670 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545931 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546102 USP48 ubiquitin specific peptidase 48 2 4
MIRT546598 SALL1 spalt like transcription factor 1 2 4
MIRT546626 RTN4 reticulon 4 2 2
MIRT547651 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547987 HCFC2 host cell factor C2 2 4
MIRT548717 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548931 CDK17 cyclin dependent kinase 17 2 2
MIRT549067 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549266 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT550460 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550806 FAM229B family with sequence similarity 229 member B 2 2
MIRT552024 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552334 ZNF704 zinc finger protein 704 2 2
MIRT552732 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT553795 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554694 RNF149 ring finger protein 149 2 2
MIRT555133 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555264 PRDM4 PR/SET domain 4 2 2
MIRT556848 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557474 GPR27 G protein-coupled receptor 27 2 4
MIRT558018 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558498 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558579 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558610 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT558650 CNKSR3 CNKSR family member 3 2 2
MIRT558986 CA8 carbonic anhydrase 8 2 2
MIRT559141 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559327 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT562021 LANCL1 LanC like 1 2 2
MIRT562869 KIAA1456 KIAA1456 2 2
MIRT563074 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563496 DLGAP3 DLG associated protein 3 2 2
MIRT563890 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564311 CCNT1 cyclin T1 2 2
MIRT564942 XKR7 XK related 7 2 2
MIRT564979 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT565423 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566824 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT571961 KIF5B kinesin family member 5B 2 2
MIRT575877 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 3
MIRT576523 Txlna taxilin alpha 2 2
MIRT614693 TRAK1 trafficking kinesin protein 1 2 2
MIRT616065 ZC3H14 zinc finger CCCH-type containing 14 2 2
MIRT618838 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT624626 ATXN2 ataxin 2 2 2
MIRT624652 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT640314 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT659248 CUL3 cullin 3 2 2
MIRT680972 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682261 RS1 retinoschisin 1 2 2
MIRT682505 GLP2R glucagon like peptide 2 receptor 2 2
MIRT693904 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT699214 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT699373 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699451 SLC16A9 solute carrier family 16 member 9 2 2
MIRT701230 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT702849 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT706163 CASK calcium/calmodulin dependent serine protein kinase 2 3
MIRT718990 UTP15 UTP15, small subunit processome component 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4524a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4524a-5p Cetuximab resistant tissue (colorectal carcinoma)

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