pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AURKA   
Synonyms AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7
Description aurora kinase A
Transcript NM_003600   
Other Transcripts NM_198433 , NM_198434 , NM_198435 , NM_198436 , NM_198437   
Expression
Putative miRNA Targets on AURKA
3'UTR of AURKA
(miRNA target sites are highlighted)
>AURKA|NM_003600|3'UTR
   1 GAATCGTGCAGGGGGAGAAATCCTTGAGCCAGGGCTGCCATATAACCTGACAGGAACATGCTACTGAAGTTTATTTTACC
  81 ATTGACTGCTGCCCTCAATCTAGAACGCTACACAAGAAATATTTGTTTTACTCAGCAGGTGTGCCTTAACCTCCCTATTC
 161 AGAAAGCTCCACATCAATAAACATGACACTCTGAAGTGAAAGTAGCCACGAGAATTGTGCTACTTATACTGGTTCATAAT
 241 CTGGAGGCAAGGTTCGACTGCAGCCGCCCCGTCAGCCTGTGCTAGGCATGGTGTCTTCACAGGAGGCAAATCCAGAGCCT
 321 GGCTGTGGGGAAAGTGACCACTCTGCCCTGACCCCGATCAGTTAAGGAGCTGTGCAATAACCTTCCTAGTACCTGAGTGA
 401 GTGTGTAACTTATTGGGTTGGCGAAGCCTGGTAAAGCTGTTGGAATGAGTATGTGATTCTTTTTAAGTATGAAAATAAAG
 481 ATATATGTACAGACTTGTATTTTTTCTCTGGTGGCATTCCTTTAGGAATGCTGTGTGTCTGTCCGGCACCCCGGTAGGCC
 561 TGATTGGGTTTCTAGTCCTCCTTAACCACTTATCTCCCATATGAGAGTGTGAAAAATAGGAACACGTGCTCTACCTCCAT
 641 TTAGGGATTTGCTTGGGATACAGAAGAGGCCATGTGTCTCAGAGCTGTTAAGGGCTTATTTTTTTAAAACATTGGAGTCA
 721 TAGCATGTGTGTAAACTTTAAATATGCAAATAAATAAGTATCTATGTCTAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aacaGGUGAAGAAGGACGGGAc 5'
              |||:|   | ||||||| 
Target 5' tttaCCATTGACTGCTGCCCTc 3'
75 - 96 154.00 -18.20
2
miRNA  3' aaCAGGUGAAGAAGGACGGGAc 5'
            | |||||     ||||||| 
Target 5' gtGACCACT-----CTGCCCTg 3'
334 - 350 151.00 -21.30
3
miRNA  3' aacagGUGA-AGAAGGACGGGac 5'
               ::|| | | :|||:||  
Target 5' aggaaTGCTGTGTGTCTGTCCgg 3'
524 - 546 113.00 -11.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30143391 2 COSMIC
COSN31479543 22 COSMIC
COSN31523440 38 COSMIC
COSN30109236 43 COSMIC
COSN30171323 48 COSMIC
COSN31610638 88 COSMIC
COSN18743205 92 COSMIC
COSN31572932 106 COSMIC
COSN31491511 168 COSMIC
COSN31521870 255 COSMIC
COSN195679 295 COSMIC
COSN26633942 353 COSMIC
COSN27468612 545 COSMIC
COSN20320009 700 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1339965708 2 dbSNP
rs34361943 3 dbSNP
rs35436934 5 dbSNP
rs777727345 6 dbSNP
rs1418545469 8 dbSNP
rs1051125021 9 dbSNP
rs755910157 12 dbSNP
rs201506695 15 dbSNP
rs752715782 16 dbSNP
rs1158140429 19 dbSNP
rs374112531 25 dbSNP
rs1459612530 30 dbSNP
rs1450182996 32 dbSNP
rs781138597 34 dbSNP
rs754845385 38 dbSNP
rs923449464 40 dbSNP
rs568671421 42 dbSNP
rs765223868 46 dbSNP
rs1447513043 47 dbSNP
rs967451253 59 dbSNP
rs901856033 63 dbSNP
rs34189236 69 dbSNP
rs538529879 84 dbSNP
rs1284373766 86 dbSNP
rs1258736858 98 dbSNP
rs566735992 106 dbSNP
rs138719629 109 dbSNP
rs777898038 122 dbSNP
rs924442461 124 dbSNP
rs1321649449 130 dbSNP
rs1281211145 132 dbSNP
rs187071479 133 dbSNP
rs1271737526 136 dbSNP
rs958693921 143 dbSNP
rs3202520 158 dbSNP
rs1042902893 160 dbSNP
rs751201081 163 dbSNP
rs567314846 172 dbSNP
rs1225115459 173 dbSNP
rs550646656 174 dbSNP
rs1367962330 176 dbSNP
rs1034026906 177 dbSNP
rs1002114894 178 dbSNP
rs947227974 189 dbSNP
rs1297553672 190 dbSNP
rs1258466329 193 dbSNP
rs915789900 209 dbSNP
rs991833162 210 dbSNP
rs1024762859 221 dbSNP
rs993243044 222 dbSNP
rs1169511351 225 dbSNP
rs1331397358 226 dbSNP
rs1390290914 228 dbSNP
rs1334287778 229 dbSNP
rs1356969328 232 dbSNP
rs1412602723 238 dbSNP
rs897588664 246 dbSNP
rs6099119 254 dbSNP
rs752966779 255 dbSNP
rs1179115541 256 dbSNP
rs971838743 257 dbSNP
rs765397114 265 dbSNP
rs961824625 266 dbSNP
rs1016030094 269 dbSNP
rs562313963 270 dbSNP
rs1176006486 273 dbSNP
rs565441568 275 dbSNP
rs6099118 285 dbSNP
rs1428854860 289 dbSNP
rs182111018 297 dbSNP
rs1371234454 301 dbSNP
rs998206784 305 dbSNP
rs1173699331 306 dbSNP
rs1203101670 313 dbSNP
rs901823116 314 dbSNP
rs753602980 316 dbSNP
rs1376677622 322 dbSNP
rs1432328341 342 dbSNP
rs141918262 350 dbSNP
rs977577622 352 dbSNP
rs903910548 355 dbSNP
rs1312579524 356 dbSNP
rs147562941 370 dbSNP
rs1222045363 377 dbSNP
rs990204292 381 dbSNP
rs1208863017 383 dbSNP
rs947198530 390 dbSNP
rs149949777 395 dbSNP
rs1206669420 397 dbSNP
rs1309424647 399 dbSNP
rs915741694 402 dbSNP
rs573653067 403 dbSNP
rs1427716095 405 dbSNP
rs760722774 406 dbSNP
rs6099117 413 dbSNP
rs981137092 418 dbSNP
rs1379855479 422 dbSNP
rs8173 423 dbSNP
rs1466184103 424 dbSNP
rs1290990719 439 dbSNP
rs1383186194 441 dbSNP
rs928313968 448 dbSNP
rs1345002115 451 dbSNP
rs972106089 452 dbSNP
rs993295491 455 dbSNP
rs767174234 459 dbSNP
rs897642406 464 dbSNP
rs1218141505 465 dbSNP
rs1225534829 465 dbSNP
rs908940135 470 dbSNP
rs1259186443 482 dbSNP
rs1485396580 484 dbSNP
rs1403015234 486 dbSNP
rs1381470645 487 dbSNP
rs1254787891 495 dbSNP
rs1467116737 497 dbSNP
rs1192463642 499 dbSNP
rs1408158943 504 dbSNP
rs1183452276 510 dbSNP
rs984554362 511 dbSNP
rs6127734 525 dbSNP
rs953514762 529 dbSNP
rs1029601355 539 dbSNP
rs375567581 539 dbSNP
rs558185068 539 dbSNP
rs761382653 541 dbSNP
rs1485648430 543 dbSNP
rs774166244 544 dbSNP
rs543477147 545 dbSNP
rs1293473045 547 dbSNP
rs560044373 552 dbSNP
rs1225565503 553 dbSNP
rs903881185 554 dbSNP
rs189714472 566 dbSNP
rs902103897 569 dbSNP
rs1233645572 586 dbSNP
rs1041953129 587 dbSNP
rs117508356 593 dbSNP
rs1233391865 596 dbSNP
rs1481305382 600 dbSNP
rs1012313204 602 dbSNP
rs538810765 603 dbSNP
rs914731026 606 dbSNP
rs1475368671 609 dbSNP
rs1166085840 612 dbSNP
rs1420402205 619 dbSNP
rs1460209025 623 dbSNP
rs573885827 625 dbSNP
rs34852291 626 dbSNP
rs927321289 650 dbSNP
rs1296562851 652 dbSNP
rs746235404 653 dbSNP
rs777116415 654 dbSNP
rs971767166 659 dbSNP
rs1402250415 661 dbSNP
rs1227563659 663 dbSNP
rs907075620 666 dbSNP
rs1036299674 670 dbSNP
rs536157397 673 dbSNP
rs940311913 676 dbSNP
rs1232121132 685 dbSNP
rs1250326443 685 dbSNP
rs908908502 692 dbSNP
rs1485720635 698 dbSNP
rs1189539104 699 dbSNP
rs1163531861 702 dbSNP
rs971929893 706 dbSNP
rs1181685858 711 dbSNP
rs984523063 712 dbSNP
rs1412197463 713 dbSNP
rs1165547468 716 dbSNP
rs1016030587 721 dbSNP
rs567228889 723 dbSNP
rs1006419956 727 dbSNP
rs931756953 733 dbSNP
rs953146920 745 dbSNP
rs1428200177 749 dbSNP
rs1363970481 750 dbSNP
rs765066882 758 dbSNP
rs1259906070 760 dbSNP
rs1188435755 762 dbSNP
rs1029125648 764 dbSNP
rs566173582 766 dbSNP
rs140401483 768 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 6790.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' aaCAGGUGAAGAAGGACGGgac 5'
            || || |    ||| ||   
Target 5' cuGUGCAAU--AACCUUCC--- 3'
22 - 38
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000395907.1 | 3UTR | UGACCCCGAUCAGUUAAGGAGCUGUGCAAUAACCUUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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