pre-miRNA Information
pre-miRNA hsa-mir-6737   
Genomic Coordinates chr1: 153962351 - 153962420
Description Homo sapiens miR-6737 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6737-5p
Sequence 6| UUGGGGUGGUCGGCCCUGGAG |26
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766338599 4 dbSNP
rs765728788 7 dbSNP
rs757341439 9 dbSNP
rs539511149 11 dbSNP
rs764259486 12 dbSNP
rs988937601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol ADM   
Synonyms AM, PAMP
Description adrenomedullin
Transcript NM_001124   
Expression
Putative miRNA Targets on ADM
3'UTR of ADM
(miRNA target sites are highlighted)
>ADM|NM_001124|3'UTR
   1 GATTTAGGCGCCCATGGTACAAGGAATAGTCGCGCAAGCATCCCGCTGGTGCCTCCCGGGACGAAGGACTTCCCGAGCGG
  81 TGTGGGGACCGGGCTCTGACAGCCCTGCGGAGACCCTGAGTCCGGGAGGCACCGTCCGGCGGCGAGCTCTGGCTTTGCAA
 161 GGGCCCCTCCTTCTGGGGGCTTCGCTTCCTTAGCCTTGCTCAGGTGCAAGTGCCCCAGGGGGCGGGGTGCAGAAGAATCC
 241 GAGTGTTTGCCAGGCTTAAGGAGAGGAGAAACTGAGAAATGAATGCTGAGACCCCCGGAGCAGGGGTCTGAGCCACAGCC
 321 GTGCTCGCCCACAAACTGATTTCTCACGGCGTGTCACCCCACCAGGGCGCAAGCCTCACTATTACTTGAACTTTCCAAAA
 401 CCTAAAGAGGAAAAGTGCAATGCGTGTTGTACATACAGAGGTAACTATCAATATTTAAGTTTGTTGCTGTCAAGATTTTT
 481 TTTGTAACTTCAAATATAGAGATATTTTTGTACGTTATATATTGTATTAAGGGCATTTTAAAAGCAATTATATTGTCCTC
 561 CCCTATTTTAAGACGTGAATGTCTCAGCGAGGTGTAAAGTTGTTCGCCGCGTGGAATGTGAGTGTGTTTGTGTGCATGAA
 641 AGAGAAAGACTGATTACCTCCTGTGTGGAAGAAGGAAACACCGAGTCTCTGTATAATCTATTTACATAAAATGGGTGATA
 721 TGCGAACAGCAAACCAATAAACTGTCTCAATGCTGATTCATAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            :|| |||  ::||||||| 
Target 5' tcTCACGGCGTGTCACCCCAc 3'
342 - 362 159.00 -20.20
2
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            :||||  | | ::||||| 
Target 5' gcTCAGGTGCAAGTGCCCCAg 3'
198 - 218 127.00 -19.30
3
miRNA  3' gaGGUCC----CGGC----UGGUGGGGUu 5'
            | |||    |:||    | ||:|||: 
Target 5' taCAAGGAATAGTCGCGCAAGCATCCCGc 3'
18 - 46 115.00 -14.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30190695 11 COSMIC
COSN19748471 25 COSMIC
COSN30513998 34 COSMIC
COSN30484335 45 COSMIC
COSN30486870 57 COSMIC
COSN30670872 91 COSMIC
COSN30481488 92 COSMIC
COSN26965270 94 COSMIC
COSN15668380 102 COSMIC
COSN28745394 111 COSMIC
COSN20317012 123 COSMIC
COSN31522798 153 COSMIC
COSN28775574 221 COSMIC
COSN31483531 275 COSMIC
COSN8640764 426 COSMIC
COSN31565128 483 COSMIC
COSN31569914 484 COSMIC
COSN20107967 564 COSMIC
COSN26550537 631 COSMIC
COSN31544120 730 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750807199 10 dbSNP
rs776259273 12 dbSNP
rs761204476 25 dbSNP
rs765261625 26 dbSNP
rs773056918 28 dbSNP
rs1168916415 33 dbSNP
rs1390156430 38 dbSNP
rs762938447 43 dbSNP
rs1053442018 45 dbSNP
rs5006 50 dbSNP
rs1048316811 53 dbSNP
rs888376013 57 dbSNP
rs1285950633 58 dbSNP
rs1448827117 61 dbSNP
rs1399704063 62 dbSNP
rs1305751624 65 dbSNP
rs1004417819 67 dbSNP
rs1036867976 71 dbSNP
rs1401418701 75 dbSNP
rs893600937 86 dbSNP
rs563007247 87 dbSNP
rs901039918 92 dbSNP
rs34779934 96 dbSNP
rs537377545 96 dbSNP
rs890643904 100 dbSNP
rs551969487 104 dbSNP
rs1126517 111 dbSNP
rs1285210430 114 dbSNP
rs1030397662 122 dbSNP
rs1458832919 125 dbSNP
rs1258407246 127 dbSNP
rs1220548904 129 dbSNP
rs1015136712 134 dbSNP
rs953355840 138 dbSNP
rs1007529303 139 dbSNP
rs1219793987 142 dbSNP
rs571734375 147 dbSNP
rs994834633 152 dbSNP
rs1027594141 153 dbSNP
rs958319205 158 dbSNP
rs1263578491 164 dbSNP
rs1377932766 165 dbSNP
rs568261437 166 dbSNP
rs1456703197 180 dbSNP
rs547683457 186 dbSNP
rs566966043 194 dbSNP
rs5007 198 dbSNP
rs1437272148 202 dbSNP
rs535855305 208 dbSNP
rs1176326861 214 dbSNP
rs1419661509 215 dbSNP
rs970591627 216 dbSNP
rs1420699096 217 dbSNP
rs981836242 219 dbSNP
rs555693252 223 dbSNP
rs923888592 229 dbSNP
rs956609642 240 dbSNP
rs989172487 242 dbSNP
rs1487362775 255 dbSNP
rs1267026181 267 dbSNP
rs1223069637 274 dbSNP
rs576108942 277 dbSNP
rs766891339 289 dbSNP
rs914899422 293 dbSNP
rs931613738 294 dbSNP
rs1242403266 302 dbSNP
rs556649284 304 dbSNP
rs1300822338 305 dbSNP
rs1349044711 308 dbSNP
rs576918361 309 dbSNP
rs1461909535 311 dbSNP
rs1294515150 313 dbSNP
rs1399875455 315 dbSNP
rs911595669 321 dbSNP
rs1161033819 327 dbSNP
rs1420959841 328 dbSNP
rs1363914723 329 dbSNP
rs1174864053 333 dbSNP
rs1431117159 345 dbSNP
rs1269129357 346 dbSNP
rs926377113 347 dbSNP
rs1487877442 353 dbSNP
rs1036484162 358 dbSNP
rs538321065 361 dbSNP
rs1398280846 375 dbSNP
rs558749396 375 dbSNP
rs1486217618 382 dbSNP
rs1255520976 388 dbSNP
rs78807204 389 dbSNP
rs1231277330 404 dbSNP
rs937630115 415 dbSNP
rs983795406 417 dbSNP
rs757767382 424 dbSNP
rs537248444 427 dbSNP
rs1280405088 435 dbSNP
rs995037571 441 dbSNP
rs1302338176 442 dbSNP
rs939951805 448 dbSNP
rs1338966508 449 dbSNP
rs1300548511 458 dbSNP
rs1401174159 460 dbSNP
rs572125585 475 dbSNP
rs1301768690 476 dbSNP
rs894494120 476 dbSNP
rs1464170903 478 dbSNP
rs541381616 480 dbSNP
rs1176784402 484 dbSNP
rs1312487749 485 dbSNP
rs1477361582 491 dbSNP
rs1024402641 494 dbSNP
rs561156410 494 dbSNP
rs1447540363 501 dbSNP
rs900993429 502 dbSNP
rs933836969 515 dbSNP
rs1484317956 520 dbSNP
rs1216171432 528 dbSNP
rs753320727 535 dbSNP
rs1198293556 537 dbSNP
rs1051768156 551 dbSNP
rs35440828 556 dbSNP
rs1340402853 557 dbSNP
rs34354539 560 dbSNP
rs397737206 560 dbSNP
rs74834059 560 dbSNP
rs199897268 565 dbSNP
rs200599471 566 dbSNP
rs201588733 567 dbSNP
rs543043922 569 dbSNP
rs1007474908 575 dbSNP
rs953080044 576 dbSNP
rs4698 580 dbSNP
rs1464807799 582 dbSNP
rs1416898394 584 dbSNP
rs911682659 595 dbSNP
rs531869867 606 dbSNP
rs944433043 609 dbSNP
rs551565001 610 dbSNP
rs893832147 612 dbSNP
rs1425597034 618 dbSNP
rs919438478 619 dbSNP
rs754519436 623 dbSNP
rs565520785 627 dbSNP
rs1475408028 630 dbSNP
rs1167083922 633 dbSNP
rs1260320751 634 dbSNP
rs930788702 637 dbSNP
rs1356158863 645 dbSNP
rs1264182816 651 dbSNP
rs1384313894 659 dbSNP
rs756289325 672 dbSNP
rs1315167380 676 dbSNP
rs1126716 681 dbSNP
rs1049304694 689 dbSNP
rs1409494301 690 dbSNP
rs1021646099 692 dbSNP
rs1410313904 692 dbSNP
rs1161348199 695 dbSNP
rs5008 695 dbSNP
rs1459397203 712 dbSNP
rs1385875753 716 dbSNP
rs780374999 728 dbSNP
rs1356304808 733 dbSNP
rs1012953715 738 dbSNP
rs1240245513 740 dbSNP
rs34056369 744 dbSNP
rs907310284 747 dbSNP
rs192534446 753 dbSNP
rs145100579 755 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 133.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaGGUCCCG-GCUGGUGGGGUu 5'
            ||||||| | |  :||:|| 
Target 5' -aCCAGGGCGCAA--GCCUCAc 3'
1 - 19
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000278175.5 | 3UTR | UCACCCCACCAGGGCGCAAGCCUCACUAUUACUUGAACUUUCCAAAACCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000278175.5 | 3UTR | ACCAGGGCGCAAGCCUCACUAUUACUUGAACUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066215 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT074413 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT125300 MID1IP1 MID1 interacting protein 1 2 2
MIRT153951 NCOA3 nuclear receptor coactivator 3 2 2
MIRT452776 FAM136A family with sequence similarity 136 member A 2 2
MIRT452977 CABP4 calcium binding protein 4 2 2
MIRT454128 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455242 DDX39B DExD-box helicase 39B 2 10
MIRT459007 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459463 MUC17 mucin 17, cell surface associated 2 4
MIRT460871 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461264 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464540 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465268 TRIM28 tripartite motif containing 28 2 2
MIRT465871 TMEM43 transmembrane protein 43 2 4
MIRT466228 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT468417 SETD1B SET domain containing 1B 2 2
MIRT468684 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT473399 MDM4 MDM4, p53 regulator 2 2
MIRT473517 MAX MYC associated factor X 2 2
MIRT474511 KLHDC8A kelch domain containing 8A 2 2
MIRT475801 HDGF heparin binding growth factor 2 2
MIRT479493 CDH6 cadherin 6 2 2
MIRT480770 BMP2 bone morphogenetic protein 2 2 2
MIRT481418 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482966 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483380 SPATA6 spermatogenesis associated 6 2 4
MIRT483677 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT484328 EPN1 epsin 1 2 4
MIRT484963 UCK1 uridine-cytidine kinase 1 2 2
MIRT485908 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488149 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488943 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT491835 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT493026 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT499374 PLCG2 phospholipase C gamma 2 2 11
MIRT499723 USH1G USH1 protein network component sans 2 4
MIRT500349 ZNF385A zinc finger protein 385A 2 2
MIRT509574 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT512794 GLRX glutaredoxin 2 2
MIRT513291 SETBP1 SET binding protein 1 2 2
MIRT515697 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518255 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT522026 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523169 HIST3H3 histone cluster 3 H3 2 2
MIRT524036 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT533476 TRIM71 tripartite motif containing 71 2 2
MIRT541488 ADM adrenomedullin 2 2
MIRT553987 SRPR SRP receptor alpha subunit 2 2
MIRT571445 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574889 Plcg2 phospholipase C, gamma 2 2 7
MIRT607544 GLI2 GLI family zinc finger 2 2 2
MIRT607688 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT610072 CRLF1 cytokine receptor like factor 1 2 2
MIRT610573 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT614041 THBS2 thrombospondin 2 2 2
MIRT626318 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634005 RIF1 replication timing regulatory factor 1 2 2
MIRT639619 FGF19 fibroblast growth factor 19 2 2
MIRT647343 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT689704 ATXN2 ataxin 2 2 2
MIRT691170 APOL6 apolipoprotein L6 2 2
MIRT693165 NPR1 natriuretic peptide receptor 1 2 2
MIRT711727 NUPL2 nucleoporin like 2 2 2
MIRT711806 ELN elastin 2 2
MIRT721546 FXN frataxin 2 2
MIRT722979 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6737-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6737-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6737-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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