miRTarBase - #MIRT541566


—
pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF43   
Synonyms HTF6, KOX27, ZNF39L1
Description zinc finger protein 43
Transcript NM_003423   
Expression
Putative miRNA Targets on ZNF43
3'UTR of ZNF43
(miRNA target sites are highlighted)		 
>ZNF43|NM_003423|3'UTR
   1 ATTATACTGGTGAGAAATTCTAGAAATGTAAAGAATGTGATAAAGGCTTTACATGGTTGTCACACTTGATTGTAGGTAAG
  81 ATAATTTACATTGGAGTAAACTTCTACAAGTGTGAAGAATGTGGCAAAACTTTTAATTAATGCTCGTACCTTATTGCACA
 161 GGAAAGAATTTTTACTTGGAAAAAGGTATATACACAAAGAATGTGGAAAAGCCATTAATATGTGCTCATATCTTACTCAA
 241 CATCAGAGAGTCTGTACTTAATAAAACCATTATAGATGCAACTAGTGTCAAAAGATCTTTCAGAAAATAAAAGCCTTTAA
 321 AGTGAAGAAGATAATTCATTCTGAAGACAAACATTACAAATATTAAGAGGGTTGTAGTACCATTACTTGCATCACAGATC
 401 TTATTGTACACATTTTGTACTAAAGAAAACCCTGAAGCAGTTGCTCAAATACTGTTCAACATCAGAAAATTTATATTGGA
 481 AAAAACCCCTGGAAAATGTAATAAATTTGTAAAAACAGTTTTGAAAAACTACAGCTTATAAAACATGAGGGTCTATAATG
 561 CTTGGTTGATAGTACAAAGTTTATTCAACATCAGGGAATTTATATTGGAGAAAAACCCTACAAATGTAATCAGTTTGGAA
 641 AAACATTTTTAAAAAAACCACAGCATAGAAAACACCACAGGGTTCATACTAAAATATGTTTTTGCAGATGCAGTAAAAAT
 721 GAAAAAAATTTAATCCGAAATTAAGTTTATGTAAATATCTGAGAATTCACAGTAGAAATATCTAAGGCGCGGACACTTCA
 801 GACATTACACTAAATCAGTGCTAAGTACAGAAAACAACACAAAATAAAACTTGGTGGATAAATTATTTGTATATAACATT
 881 AAAAGAAGTAGAAGATTTTCAGTTATAATTACAATTAAAGTATACTTTTATCTTGAAAAAATTACTGATTTTTAAATTAG
 961 TGAATAATGATGTAATTAAACTCTCAAATAACTTTATGCTCTTTTTTCATTCCTGCTATATTCACATGTGAAAGCATGTG
1041 ACCAATTGTTGCTGCACCAAAGATATGAGAGATTCTTTTATTAGGTGGGCATTATTTAAAACATTTTTTATGGAACAGTA
1121 AGGATATTAAAGTGTAAGATGCAGCCAGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCTGAGGCCGGTG
1201 GATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCTGTCTTTACTAAAAATACAAAAATTTAC
1281 CAGGCACCTATAATCCCAGCTACTTCAAAGGCTGAAGCAGGAGAATCACTTGAACCTGGAAAGTGGAGGTCTCAGTGAGC
1361 CGAAATCATACCATTGCACTCCAACCTGGGCAACAAAAGTCAAACTCCATCTCAAAAAGAAAAAAAAAAAAAAAAAAGAT
1441 GCGTGATGAAAATGTAACTGGAGAGGCTCTTTGTGGTTAACTTATAAAGGAGTGATGCAGGAGATAGGTTTTCAGAGTAA
1521 TATTCTTCTGCATTATAGTGACAAAAGTTTTTTATTTTAGTTAAAATTGGTTAAATTAGTAAGTCATTTTACTTATTGTA
1601 ATTTTATGTAATTAAATGTACATTTTTAAATTTTTAGATTACATGTAAATATAACTTTTAAAAAAATGTGTTAAGACCAT
1681 TGTACATTCAATGAAGCATTATTATGCTTCTAACTTTAACCTATTTCACCTTACTCAAGAGTGTATGTAAAAGATGGTAA
1761 CAATATACTATTTGGTAACATAATGGACTAACATTTCTATTAATCTATTTCACCAGTGGCTTTCAACTGCAAATAAGTTA
1841 AAGAATATTTTTCTATAGGTTAAATATTCTTTTTTGTCTTATTTAAACTTACTGTTCTTAATTTCTGTGGGTACATAGTA
1921 TGATTTTAATTACCTTATTTTATTCTTTGTGCTATTCATAATTTTTTTTGTTTGTTTGGTTTTTTTTTTTGAGACAGAGT
2001 CTTGCTCTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAAGCTCCGCCTCCCAGGTTCACTCCATTCTC
2081 CTGCCTCAGCCTCCCAAGTAGCTGGGACCACAGGCGCCCACTACTTGTTTGGGTTTTTTTTTGGAGATGGAGTCTCGCTC
2161 TGTCACCCAGGCTGGAGTACAGTGGCATGATCTTGGCTCACTGCAACCCCCACCTCCCCGGTTCAAGTGATTCTCCTGCC
2241 TCAGCCTCCCGAATAGCTGGGATTACAGGCGTCCACCATCACACCAGGCTAATTTTTGTATTTTTAGTAGAGATGGAGTT
2321 TCACCATGTTGGCCAGGATGGTCTCGATCTTCTGACCTCATGATCTGCCTGCCTCGGCCTCCCAGAGTTCTGGGACCACA
2401 GGCATGAGCCACTGCACCTGGCCAAATGTGTATATATTTATGCAATATATAACATGTTTTGATACAGGCATATAATATGT
2481 ATTAGTCACATCAGGATAAAGTATCTATTACCTTCAGCATTTATCCTTTGTATTACAAGCCAATTCTACACTTCATTATT
2561 TTAATGTACAATTAAATTGTTATTGACTACAGGGTCATTTTAATTATAAAAATTATATAGAAGTATAAATAAAGTCCATA
2641 CATTCCTGAGTCATGAAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acGGUCG-GAGCGGGUCg 5'
            |: || ||||||||| 
Target 5' gtCTTGCTCTCGCCCAGg 3'
 1999 - 2016 155.00 -21.40
2 
miRNA  3' acGGUCGGAGCGGGUcg 5'
            |||    ||||||  
Target 5' gaCCACAGGCGCCCAct 3'
 2106 - 2122 123.00 -14.20
3 
miRNA  3' acGGUCGGA----GCGGGUCg 5'
            || ||||    | ||||| 
Target 5' tgCCTGCCTCGGCCTCCCAGa 3'
 2366 - 2386 121.00 -25.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30185003 12 COSMIC
COSN30112599 41 COSMIC
COSN31496854 53 COSMIC
COSN31497507 54 COSMIC
COSN30698897 70 COSMIC
COSN5435819 73 COSMIC
COSN30117547 98 COSMIC
COSN7118393 116 COSMIC
COSN8605341 149 COSMIC
COSN30161408 166 COSMIC
COSN31558015 212 COSMIC
COSN31566913 218 COSMIC
COSN1763023 233 COSMIC
COSN17076483 294 COSMIC
COSN17268764 658 COSMIC
COSN31961533 789 COSMIC
COSN6140028 1024 COSMIC
COSN20115663 1420 COSMIC
COSN20115664 1420 COSMIC
COSN24539547 1443 COSMIC
COSN17847051 1497 COSMIC
COSN15052547 1530 COSMIC
COSN20629034 1691 COSMIC
COSN20115662 1737 COSMIC
COSN24594521 1818 COSMIC
COSN5183869 2044 COSMIC
COSN27108593 2180 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1458566931 2 dbSNP
rs1367534224 8 dbSNP
rs776413346 9 dbSNP
rs770541572 10 dbSNP
rs1027783382 18 dbSNP
rs1384526504 20 dbSNP
rs746573925 23 dbSNP
rs772733787 27 dbSNP
rs771534748 29 dbSNP
rs1204193979 45 dbSNP
rs747556589 46 dbSNP
rs779226035 47 dbSNP
rs1219615925 49 dbSNP
rs1180266323 53 dbSNP
rs1364112721 59 dbSNP
rs1429536142 61 dbSNP
rs1172952857 63 dbSNP
rs1369322361 64 dbSNP
rs1429664577 66 dbSNP
rs1306888869 68 dbSNP
rs1024251782 69 dbSNP
rs548625244 72 dbSNP
rs572832368 75 dbSNP
rs1014168976 94 dbSNP
rs1449821291 98 dbSNP
rs1282017554 100 dbSNP
rs1462969656 102 dbSNP
rs1356845224 106 dbSNP
rs1214983064 108 dbSNP
rs1299538604 111 dbSNP
rs554331072 113 dbSNP
rs536414850 123 dbSNP
rs1340037402 140 dbSNP
rs1227496748 142 dbSNP
rs6511296 146 dbSNP
rs1444161205 147 dbSNP
rs1208307606 158 dbSNP
rs961717176 159 dbSNP
rs1015577479 162 dbSNP
rs746057520 166 dbSNP
rs951914491 168 dbSNP
rs1000567266 175 dbSNP
rs1027509556 177 dbSNP
rs1430059065 180 dbSNP
rs1449400865 185 dbSNP
rs1001331624 195 dbSNP
rs1042167325 205 dbSNP
rs1425291547 214 dbSNP
rs1415731811 223 dbSNP
rs373082300 224 dbSNP
rs1479541207 226 dbSNP
rs1430994059 227 dbSNP
rs905621747 228 dbSNP
rs1024511040 235 dbSNP
rs1041313954 236 dbSNP
rs1304000572 241 dbSNP
rs1347003172 242 dbSNP
rs1217614325 251 dbSNP
rs942950800 261 dbSNP
rs779143917 263 dbSNP
rs1210753481 266 dbSNP
rs1208966776 268 dbSNP
rs911434526 269 dbSNP
rs1480823849 272 dbSNP
rs985820873 277 dbSNP
rs1249008399 291 dbSNP
rs528683954 302 dbSNP
rs1052688733 313 dbSNP
rs1423784570 313 dbSNP
rs1457443197 317 dbSNP
rs1160868771 324 dbSNP
rs1386208752 333 dbSNP
rs936273735 336 dbSNP
rs1326332809 338 dbSNP
rs904744772 343 dbSNP
rs1434143740 348 dbSNP
rs1316819126 349 dbSNP
rs1374099698 353 dbSNP
rs1230487592 361 dbSNP
rs1049891382 363 dbSNP
rs932853560 364 dbSNP
rs1214779965 369 dbSNP
rs922791870 370 dbSNP
rs1292452198 377 dbSNP
rs1450406832 379 dbSNP
rs977266260 386 dbSNP
rs1282221792 391 dbSNP
rs1245650879 394 dbSNP
rs1472603540 396 dbSNP
rs1249321304 398 dbSNP
rs1014219986 403 dbSNP
rs1409398972 408 dbSNP
rs958615977 410 dbSNP
rs940106581 417 dbSNP
rs1392378362 419 dbSNP
rs1375983051 420 dbSNP
rs1163641431 422 dbSNP
rs1392537777 428 dbSNP
rs908551004 431 dbSNP
rs1034648852 438 dbSNP
rs1322759071 446 dbSNP
rs1371066366 452 dbSNP
rs1411792118 461 dbSNP
rs1286525245 470 dbSNP
rs1350162987 473 dbSNP
rs1297026047 483 dbSNP
rs1000216861 486 dbSNP
rs1234068072 486 dbSNP
rs904501475 486 dbSNP
rs150967782 490 dbSNP
rs984100920 492 dbSNP
rs1406929659 495 dbSNP
rs951948259 513 dbSNP
rs1178630100 514 dbSNP
rs1274378192 519 dbSNP
rs563116819 523 dbSNP
rs1468454055 530 dbSNP
rs1472065049 547 dbSNP
rs1187770058 552 dbSNP
rs1428916039 554 dbSNP
rs370054099 555 dbSNP
rs1182760230 557 dbSNP
rs1390784308 565 dbSNP
rs1010266748 566 dbSNP
rs757040441 578 dbSNP
rs182466589 590 dbSNP
rs1419523446 592 dbSNP
rs1369954650 594 dbSNP
rs201128390 597 dbSNP
rs546662686 597 dbSNP
rs143500784 598 dbSNP
rs1457209587 604 dbSNP
rs911491196 605 dbSNP
rs1263251996 622 dbSNP
rs559896185 631 dbSNP
rs1253643637 650 dbSNP
rs546562572 651 dbSNP
rs930349632 657 dbSNP
rs920241609 658 dbSNP
rs891517973 659 dbSNP
rs1031300426 663 dbSNP
rs1305224482 674 dbSNP
rs1440336609 681 dbSNP
rs999783052 682 dbSNP
rs1186645903 694 dbSNP
rs1390495422 697 dbSNP
rs1446739537 704 dbSNP
rs1384121576 708 dbSNP
rs1339238741 713 dbSNP
rs1450590524 726 dbSNP
rs189799388 729 dbSNP
rs1395615669 732 dbSNP
rs753690268 736 dbSNP
rs530286087 737 dbSNP
rs1365324600 744 dbSNP
rs1297576131 745 dbSNP
rs1313267851 746 dbSNP
rs901368393 766 dbSNP
rs1257233024 773 dbSNP
rs1342451785 778 dbSNP
rs1156615865 788 dbSNP
rs1041190380 789 dbSNP
rs940119023 790 dbSNP
rs28670427 791 dbSNP
rs148869772 795 dbSNP
rs1433695335 803 dbSNP
rs931338001 808 dbSNP
rs926609930 810 dbSNP
rs1019627546 818 dbSNP
rs1375937158 831 dbSNP
rs1459639559 835 dbSNP
rs1465761980 838 dbSNP
rs1007030152 840 dbSNP
rs1205360392 850 dbSNP
rs189203096 857 dbSNP
rs1320301909 862 dbSNP
rs1368991267 863 dbSNP
rs969970274 870 dbSNP
rs145575163 877 dbSNP
rs1328807638 892 dbSNP
rs931549981 894 dbSNP
rs1268419440 895 dbSNP
rs1206657669 896 dbSNP
rs749182288 896 dbSNP
rs1488770668 912 dbSNP
rs898871522 912 dbSNP
rs532841730 914 dbSNP
rs992634415 918 dbSNP
rs1265391496 919 dbSNP
rs1036032826 920 dbSNP
rs1432728310 920 dbSNP
rs940305525 925 dbSNP
rs1471726640 926 dbSNP
rs755934049 940 dbSNP
rs1158912144 942 dbSNP
rs144909955 942 dbSNP
rs1459925109 947 dbSNP
rs752708495 947 dbSNP
rs1390618777 950 dbSNP
rs937216496 963 dbSNP
rs999898970 968 dbSNP
rs1226121901 969 dbSNP
rs1352010592 969 dbSNP
rs1318982263 975 dbSNP
rs1306064501 983 dbSNP
rs968378018 993 dbSNP
rs1027933865 995 dbSNP
rs572920433 999 dbSNP
rs1206034956 1001 dbSNP
rs1297794420 1008 dbSNP
rs1418945084 1009 dbSNP
rs560823187 1011 dbSNP
rs574463747 1012 dbSNP
rs1165413802 1013 dbSNP
rs1442633253 1015 dbSNP
rs1367414659 1016 dbSNP
rs1041614515 1017 dbSNP
rs12462709 1018 dbSNP
rs774145502 1021 dbSNP
rs1415002085 1022 dbSNP
rs1425974516 1029 dbSNP
rs1448201543 1032 dbSNP
rs887267347 1041 dbSNP
rs988784599 1045 dbSNP
rs1368461704 1051 dbSNP
rs1430938394 1054 dbSNP
rs965325603 1057 dbSNP
rs1371827172 1058 dbSNP
rs1019680158 1063 dbSNP
rs1259279549 1065 dbSNP
rs1048550680 1072 dbSNP
rs556915045 1079 dbSNP
rs537949492 1083 dbSNP
rs1310300183 1091 dbSNP
rs1358662650 1094 dbSNP
rs1228970374 1096 dbSNP
rs1276897251 1102 dbSNP
rs1045047298 1103 dbSNP
rs1490632152 1110 dbSNP
rs538205531 1111 dbSNP
rs948645588 1116 dbSNP
rs1180535114 1118 dbSNP
rs1294328355 1122 dbSNP
rs889995790 1123 dbSNP
rs1244424528 1124 dbSNP
rs917138443 1126 dbSNP
rs1427308546 1136 dbSNP
rs993145427 1149 dbSNP
rs538722554 1157 dbSNP
rs1270865805 1167 dbSNP
rs1027565815 1169 dbSNP
rs924427764 1196 dbSNP
rs577839475 1197 dbSNP
rs1381716851 1201 dbSNP
rs1037259705 1202 dbSNP
rs1435749850 1202 dbSNP
rs111593439 1208 dbSNP
rs867359845 1213 dbSNP
rs1339933771 1217 dbSNP
rs940358915 1221 dbSNP
rs1214128535 1223 dbSNP
rs1324760575 1227 dbSNP
rs1277872413 1228 dbSNP
rs1208199733 1231 dbSNP
rs1262937717 1234 dbSNP
rs1138278 1238 dbSNP
rs1138279 1249 dbSNP
rs978511513 1269 dbSNP
rs968412067 1271 dbSNP
rs1190874478 1272 dbSNP
rs1246798273 1279 dbSNP
rs1475369013 1281 dbSNP
rs144504055 1287 dbSNP
rs996487022 1290 dbSNP
rs1304688306 1292 dbSNP
rs1404870272 1297 dbSNP
rs1457605048 1314 dbSNP
rs569385922 1317 dbSNP
rs1363014616 1321 dbSNP
rs1429868432 1325 dbSNP
rs1275517780 1329 dbSNP
rs966024779 1338 dbSNP
rs1365540326 1339 dbSNP
rs1168397805 1343 dbSNP
rs1138285 1347 dbSNP
rs1476145828 1348 dbSNP
rs1217528148 1351 dbSNP
rs534566058 1355 dbSNP
rs1019900195 1361 dbSNP
rs1004871471 1362 dbSNP
rs887299997 1364 dbSNP
rs1480521464 1365 dbSNP
rs1266566678 1370 dbSNP
rs572639033 1377 dbSNP
rs567292155 1383 dbSNP
rs1220653898 1394 dbSNP
rs995606290 1395 dbSNP
rs1274368780 1400 dbSNP
rs1198065818 1401 dbSNP
rs1337548981 1402 dbSNP
rs183795775 1404 dbSNP
rs977581144 1406 dbSNP
rs1224391033 1413 dbSNP
rs1347566176 1415 dbSNP
rs1281590010 1416 dbSNP
rs73013606 1419 dbSNP
rs1330294915 1420 dbSNP
rs373551288 1421 dbSNP
rs1329524057 1422 dbSNP
rs201483434 1422 dbSNP
rs1411535428 1423 dbSNP
rs1397505323 1427 dbSNP
rs1045478798 1428 dbSNP
rs1324184451 1433 dbSNP
rs1470886265 1436 dbSNP
rs1169288379 1437 dbSNP
rs1220584978 1438 dbSNP
rs1229223321 1438 dbSNP
rs1286882562 1438 dbSNP
rs1351517564 1438 dbSNP
rs142866933 1438 dbSNP
rs1434489067 1438 dbSNP
rs539673519 1438 dbSNP
rs74174041 1438 dbSNP
rs764492991 1438 dbSNP
rs769979867 1438 dbSNP
rs776033696 1438 dbSNP
rs146924824 1440 dbSNP
rs559049795 1440 dbSNP
rs913168353 1442 dbSNP
rs949446898 1443 dbSNP
rs965377968 1448 dbSNP
rs1019565569 1449 dbSNP
rs1189066407 1453 dbSNP
rs1021326978 1454 dbSNP
rs917907546 1458 dbSNP
rs985601904 1460 dbSNP
rs748302487 1461 dbSNP
rs1057072355 1469 dbSNP
rs1422610485 1475 dbSNP
rs1302639053 1482 dbSNP
rs796084805 1483 dbSNP
rs1371203724 1487 dbSNP
rs1184613049 1489 dbSNP
rs934564776 1490 dbSNP
rs1257529963 1492 dbSNP
rs924460474 1501 dbSNP
rs996093704 1510 dbSNP
rs1335363297 1516 dbSNP
rs1449297048 1521 dbSNP
rs191973569 1523 dbSNP
rs559334964 1525 dbSNP
rs1013835612 1530 dbSNP
rs111310438 1535 dbSNP
rs1342189696 1536 dbSNP
rs1206643180 1537 dbSNP
rs1248065351 1544 dbSNP
rs1056818093 1547 dbSNP
rs1001173842 1554 dbSNP
rs1238924935 1558 dbSNP
rs1442742487 1566 dbSNP
rs1162802233 1569 dbSNP
rs755180258 1585 dbSNP
rs920991474 1586 dbSNP
rs1279850736 1589 dbSNP
rs1444331522 1595 dbSNP
rs1336561828 1596 dbSNP
rs1380986441 1596 dbSNP
rs1396759372 1596 dbSNP
rs975560906 1616 dbSNP
rs1299056591 1618 dbSNP
rs1374502298 1618 dbSNP
rs1367971691 1619 dbSNP
rs965114616 1622 dbSNP
rs1019682748 1628 dbSNP
rs1249054100 1631 dbSNP
rs1166855603 1652 dbSNP
rs947232013 1659 dbSNP
rs1200641272 1660 dbSNP
rs1280503219 1660 dbSNP
rs913053827 1660 dbSNP
rs1053000619 1667 dbSNP
rs59463041 1667 dbSNP
rs61417014 1667 dbSNP
rs1191127672 1668 dbSNP
rs1466772025 1669 dbSNP
rs59872753 1669 dbSNP
rs201618083 1671 dbSNP
rs1404152180 1676 dbSNP
rs983065880 1677 dbSNP
rs376360385 1679 dbSNP
rs951583806 1680 dbSNP
rs920025003 1681 dbSNP
rs1027157018 1689 dbSNP
rs1292867325 1690 dbSNP
rs1325306496 1691 dbSNP
rs1233316782 1696 dbSNP
rs974169651 1697 dbSNP
rs1320962824 1716 dbSNP
rs961568167 1723 dbSNP
rs1466200477 1734 dbSNP
rs77590875 1739 dbSNP
rs374951438 1745 dbSNP
rs1438198763 1753 dbSNP
rs1201050814 1759 dbSNP
rs995638852 1760 dbSNP
rs1480200782 1765 dbSNP
rs1160374281 1769 dbSNP
rs576416088 1773 dbSNP
rs546713452 1774 dbSNP
rs1184750060 1782 dbSNP
rs905352613 1785 dbSNP
rs1033906125 1787 dbSNP
rs1241290340 1788 dbSNP
rs1001625141 1789 dbSNP
rs777073223 1799 dbSNP
rs1284713191 1800 dbSNP
rs1222445830 1802 dbSNP
rs1023759338 1805 dbSNP
rs1014068973 1806 dbSNP
rs1225299329 1821 dbSNP
rs1288783358 1828 dbSNP
rs896514762 1830 dbSNP
rs528424689 1833 dbSNP
rs1260113980 1850 dbSNP
rs1488759929 1856 dbSNP
rs1052836398 1866 dbSNP
rs1308527808 1867 dbSNP
rs1266779275 1869 dbSNP
rs905508515 1872 dbSNP
rs755593182 1876 dbSNP
rs934597387 1877 dbSNP
rs1414444706 1879 dbSNP
rs371844016 1894 dbSNP
rs1417748150 1900 dbSNP
rs903070124 1914 dbSNP
rs1042879952 1918 dbSNP
rs943840812 1920 dbSNP
rs1164935097 1934 dbSNP
rs912494115 1945 dbSNP
rs1403975552 1947 dbSNP
rs1308307496 1948 dbSNP
rs1375027734 1952 dbSNP
rs1389527463 1955 dbSNP
rs1384373869 1959 dbSNP
rs368677727 1961 dbSNP
rs921095803 1963 dbSNP
rs1358882301 1964 dbSNP
rs1205925581 1970 dbSNP
rs932669398 1970 dbSNP
rs1446870594 1974 dbSNP
rs747426823 1975 dbSNP
rs1257218018 1979 dbSNP
rs943773859 1979 dbSNP
rs919928072 1983 dbSNP
rs1423496551 1986 dbSNP
rs1168666816 1989 dbSNP
rs1379564872 1991 dbSNP
rs549178950 1991 dbSNP
rs974599985 1991 dbSNP
rs1454359352 1999 dbSNP
rs1381945996 2000 dbSNP
rs961454630 2000 dbSNP
rs1229309013 2005 dbSNP
rs1275132123 2006 dbSNP
rs908591626 2007 dbSNP
rs1204040451 2009 dbSNP
rs189928226 2010 dbSNP
rs575493928 2019 dbSNP
rs563474010 2031 dbSNP
rs545257259 2032 dbSNP
rs1243139276 2033 dbSNP
rs577927000 2034 dbSNP
rs553075375 2041 dbSNP
rs1186597678 2052 dbSNP
rs1420978484 2054 dbSNP
rs1446900086 2056 dbSNP
rs375300424 2057 dbSNP
rs960840124 2064 dbSNP
rs1334436470 2072 dbSNP
rs1405274174 2073 dbSNP
rs1034369629 2074 dbSNP
rs1359892579 2075 dbSNP
rs1486220127 2075 dbSNP
rs1214037658 2079 dbSNP
rs1302290911 2093 dbSNP
rs1244093418 2094 dbSNP
rs1202233376 2098 dbSNP
rs981032496 2111 dbSNP
rs1218501361 2116 dbSNP
rs1487217950 2119 dbSNP
rs534710735 2124 dbSNP
rs1474165706 2131 dbSNP
rs1185429634 2135 dbSNP
rs1284964265 2138 dbSNP
rs1011320433 2143 dbSNP
rs1021377286 2143 dbSNP
rs1173991059 2156 dbSNP
rs1428286790 2157 dbSNP
rs76390694 2158 dbSNP
rs757409700 2170 dbSNP
rs536618770 2171 dbSNP
rs1430184185 2176 dbSNP
rs1227282553 2193 dbSNP
rs1294179438 2198 dbSNP
rs1362035346 2199 dbSNP
rs567422850 2203 dbSNP
rs1271632718 2208 dbSNP
rs928036331 2210 dbSNP
rs1221873410 2216 dbSNP
rs1049995864 2219 dbSNP
rs1027272880 2220 dbSNP
rs368418721 2221 dbSNP
rs974318262 2224 dbSNP
rs1446919565 2230 dbSNP
rs1214478133 2235 dbSNP
rs1268891317 2240 dbSNP
rs932506635 2262 dbSNP
rs1427135418 2271 dbSNP
rs969566630 2273 dbSNP
rs555116951 2282 dbSNP
rs375275125 2285 dbSNP
rs1038448284 2287 dbSNP
rs749516048 2288 dbSNP
rs536931561 2302 dbSNP
rs1399980884 2312 dbSNP
rs1164331245 2314 dbSNP
rs1421720815 2317 dbSNP
rs1403159931 2326 dbSNP
rs1191786253 2327 dbSNP
rs1302822164 2331 dbSNP
rs569484604 2338 dbSNP
rs147875950 2345 dbSNP
rs1278094037 2346 dbSNP
rs185459499 2346 dbSNP
rs903856576 2348 dbSNP
rs571512319 2352 dbSNP
rs1042994711 2354 dbSNP
rs1489322157 2354 dbSNP
rs1219579272 2357 dbSNP
rs1267817246 2359 dbSNP
rs947290291 2360 dbSNP
rs201936340 2370 dbSNP
rs1260419797 2371 dbSNP
rs546645953 2375 dbSNP
rs117329296 2376 dbSNP
rs1216445044 2379 dbSNP
rs943802088 2383 dbSNP
rs1397503178 2390 dbSNP
rs1339389917 2392 dbSNP
rs1327302031 2393 dbSNP
rs1335491687 2403 dbSNP
rs955812225 2407 dbSNP
rs1317821385 2413 dbSNP
rs912262811 2420 dbSNP
rs1381218812 2424 dbSNP
rs1031272719 2430 dbSNP
rs1007859632 2438 dbSNP
rs1339663838 2438 dbSNP
rs567646698 2440 dbSNP
rs1197130958 2445 dbSNP
rs563941363 2455 dbSNP
rs891000576 2456 dbSNP
rs1204056830 2464 dbSNP
rs1365917712 2468 dbSNP
rs1442642278 2470 dbSNP
rs1183072117 2478 dbSNP
rs919572776 2480 dbSNP
rs1373682196 2501 dbSNP
rs1476523642 2504 dbSNP
rs1166418882 2509 dbSNP
rs1028240554 2517 dbSNP
rs1470544176 2520 dbSNP
rs1293515403 2523 dbSNP
rs751172137 2530 dbSNP
rs1452461286 2532 dbSNP
rs374526296 2535 dbSNP
rs970015473 2540 dbSNP
rs1168567622 2543 dbSNP
rs1465153335 2548 dbSNP
rs916773184 2549 dbSNP
rs563401273 2558 dbSNP
rs1268120870 2560 dbSNP
rs1338331285 2567 dbSNP
rs1223911327 2568 dbSNP
rs1038236128 2569 dbSNP
rs1459952742 2571 dbSNP
rs1202895601 2574 dbSNP
rs1262311789 2576 dbSNP
rs1448852452 2579 dbSNP
rs79158455 2580 dbSNP
rs960831411 2604 dbSNP
rs1372778149 2607 dbSNP
rs1434749634 2608 dbSNP
rs1031080699 2609 dbSNP
rs999564237 2614 dbSNP
rs754434445 2617 dbSNP
rs1190556515 2621 dbSNP
rs1290010421 2622 dbSNP
rs1022242344 2623 dbSNP
rs1387774823 2626 dbSNP
rs1383475181 2629 dbSNP
rs1011463891 2630 dbSNP
rs1339454181 2634 dbSNP
rs899706599 2636 dbSNP
rs1223707585 2640 dbSNP
rs371694133 2642 dbSNP
rs150628716 2645 dbSNP
rs1196262561 2647 dbSNP
rs1316709090 2648 dbSNP
rs939336494 2650 dbSNP
rs1008510950 2652 dbSNP
rs1261305353 2662 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7594.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714646. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acgguCG-GAGCGGGUCg 5'
               || ||||||||| 
Target 5' ---uuGCUCUCGCCCAGg 3'
 		1 - 15
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acggucGGAGCGGGUCg 5'
                :||||||||| 
Target 5' ------UCUCGCCCAGg 3'
 		1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_003423 | 3UTR | UCUUGCUCUCGCCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_003423 | 3UTR | CUCGCCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_003423 | 3UTR | CAGGCUGGAGUGCAGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_003423 | 3UTR | CCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000594012.1 | 3UTR | UCUCGCCCAGGCUGGAGUGCAGUGGCGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM714646
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repA
Location of target site ENST00000594012.1 | 3UTR | UUGCUCUCGCCCAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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