miRTarBase - #MIRT541787


—
pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TBCCD1   
Synonyms -
Description TBCC domain containing 1
Transcript NM_001134415   
Other Transcripts NM_018138   
Expression
Putative miRNA Targets on TBCCD1
3'UTR of TBCCD1
(miRNA target sites are highlighted)		 
>TBCCD1|NM_001134415|3'UTR
   1 GGATCTTACATGCAGACACTGGGCCCTGGAAATACAAGGATAAATGGAGGATGGTGCTCATCTTGAAACTTGAAACTAAA
  81 TTGGGAAGGTGCTATTGCTGCTTAAGAGACATTGGGACTTTTCTGTCTTTTTTTTTTTTTTTTTTTGAGGCAGAGTCTTG
 161 TTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCTGCCTCCCGGGTTCACGCCATTCTCCT
 241 GCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCCAATTTTTTTTGTATTTTTAGTAGAGAC
 321 GGGGTTTCACCGTGTTAGTCAGGATGGTCTCGATTTCCTGACCTCGTGATCCGCCCATCTCGGCCTCCCAAAGTGCTGGG
 401 ATTACAGGCGTGAGCCACCGTGCCCAGCCTTCTGTTCTATTTAAGAACTTTGATTTCCATTCCATTTTCATTTATTACTG
 481 TTTAGGCCGAATTTTCGCTAAACTTCTGACTTTCATATAAACATATTGCTTATAGAACATCAGAAGACTCGTCTTTGTGA
 561 TGCCCAAATGAAAAAGTTGGTGAAGGTAGTACCATTGTATGTATGTTAATATTAAAGCAACTGAGTGTAGATTTGCAACT
 641 ATAGTGTGTATCTTCATTTGTGTGATGAAAGAGTTTTATTCTTTCTAGAGTTAAATAAGAGTTTTATAGTTCTTTGTAAC
 721 TATTTAAAAGGAAATTGCTACTCCTTTTAAAAAATAATTGGAAAGGAAGTATGATTTGTTGGTATATAGACATAGAAATA
 801 GTTTTATACTATATTTTAGTCCTTAAAGTATGGAACTTAATGAAATTGTTTAAAAAAATCTTTATTTTTCACTTCCTGCT
 881 TCAAATTTTCAATAAACAAACTCTAAAGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acggucggAGCGGGUCg 5'
                  |||||||| 
Target 5' ttgttctgTCGCCCAGg 3'
 158 - 174 145.00 -15.00
2 
miRNA  3' acGGUCGGAGCGGGUCg 5'
            ||| || |||||:| 
Target 5' cgCCA-CCACGCCCGGc 3'
 277 - 292 138.00 -24.30
3 
miRNA  3' acGGUCGGAGCGGGUCg 5'
            ||| || :|||||| 
Target 5' agCCA-CCGTGCCCAGc 3'
 413 - 428 138.00 -24.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31495487 10 COSMIC
COSN18727456 75 COSMIC
COSN18728010 75 COSMIC
COSN28651091 203 COSMIC
COSN9539818 436 COSMIC
COSN9002828 747 COSMIC
COSN15064213 991 COSMIC
COSN26745601 1221 COSMIC
COSN25859347 1747 COSMIC
COSN16600546 1827 COSMIC
COSN1936665 1840 COSMIC
COSN1936663 2085 COSMIC
COSN17637338 2101 COSMIC
COSN30387163 2487 COSMIC
COSN16447309 2521 COSMIC
COSN9539816 2991 COSMIC
COSN16587711 3386 COSMIC
COSN27488317 3876 COSMIC
COSN29445458 3877 COSMIC
COSN1936661 3935 COSMIC
COSN1936659 3948 COSMIC
COSN5147495 4363 COSMIC
COSN20788095 4526 COSMIC
COSN31971704 4538 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1192364778 2 dbSNP
rs754303354 3 dbSNP
rs756455831 4 dbSNP
rs1248212933 5 dbSNP
rs753159322 7 dbSNP
rs767816054 10 dbSNP
rs1394666411 12 dbSNP
rs1376055606 13 dbSNP
rs59882959 15 dbSNP
rs371733308 18 dbSNP
rs530220241 19 dbSNP
rs751102843 19 dbSNP
rs1369218688 24 dbSNP
rs1164954473 27 dbSNP
rs996341234 32 dbSNP
rs202198614 35 dbSNP
rs367856038 36 dbSNP
rs771696296 38 dbSNP
rs375235183 45 dbSNP
rs765941018 49 dbSNP
rs778325619 51 dbSNP
rs1227023477 52 dbSNP
rs1309578975 54 dbSNP
rs760541079 55 dbSNP
rs559453827 60 dbSNP
rs547409552 75 dbSNP
rs181175321 78 dbSNP
rs1026483918 79 dbSNP
rs1486368998 83 dbSNP
rs1210970220 97 dbSNP
rs906967990 102 dbSNP
rs565268355 107 dbSNP
rs997719582 113 dbSNP
rs1044559192 117 dbSNP
rs1279610922 124 dbSNP
rs948575994 126 dbSNP
rs1345488915 127 dbSNP
rs966142121 133 dbSNP
rs1018129649 135 dbSNP
rs73057405 136 dbSNP
rs903868624 142 dbSNP
rs1313546260 143 dbSNP
rs576604987 144 dbSNP
rs1394542333 145 dbSNP
rs771564455 149 dbSNP
rs1358854683 151 dbSNP
rs1446053218 154 dbSNP
rs1281438972 158 dbSNP
rs1374523608 161 dbSNP
rs887895963 170 dbSNP
rs923909685 171 dbSNP
rs747590608 177 dbSNP
rs1297835769 178 dbSNP
rs892420169 184 dbSNP
rs1056217890 193 dbSNP
rs1350658336 212 dbSNP
rs939208096 216 dbSNP
rs1462503383 219 dbSNP
rs112418031 224 dbSNP
rs1234441660 235 dbSNP
rs73057404 250 dbSNP
rs1174446343 274 dbSNP
rs1206213682 283 dbSNP
rs1233043252 289 dbSNP
rs1479404762 292 dbSNP
rs768187432 296 dbSNP
rs1396876182 297 dbSNP
rs975265232 299 dbSNP
rs964845597 305 dbSNP
rs941008023 308 dbSNP
rs909554854 309 dbSNP
rs1355331499 310 dbSNP
rs1446581107 311 dbSNP
rs1329695372 312 dbSNP
rs1373876267 313 dbSNP
rs1247893020 315 dbSNP
rs1442320537 316 dbSNP
rs1274731622 322 dbSNP
rs982485044 328 dbSNP
rs1016389245 333 dbSNP
rs1273359568 343 dbSNP
rs746292940 347 dbSNP
rs781641198 348 dbSNP
rs1006394090 349 dbSNP
rs1254615282 352 dbSNP
rs1468721419 355 dbSNP
rs1198091711 356 dbSNP
rs1259402250 365 dbSNP
rs886703679 375 dbSNP
rs1477119313 377 dbSNP
rs1169710828 385 dbSNP
rs541528171 391 dbSNP
rs1424662592 400 dbSNP
rs544795457 408 dbSNP
rs574499827 410 dbSNP
rs1002522595 411 dbSNP
rs906890773 411 dbSNP
rs1323488517 413 dbSNP
rs1329856530 416 dbSNP
rs1044150870 421 dbSNP
rs1270248433 422 dbSNP
rs1339488034 424 dbSNP
rs948455846 427 dbSNP
rs1274594870 435 dbSNP
rs1335239561 439 dbSNP
rs1209015799 443 dbSNP
rs140758642 446 dbSNP
rs1448633906 447 dbSNP
rs966632083 451 dbSNP
rs1195464721 455 dbSNP
rs1017661691 459 dbSNP
rs1008066033 465 dbSNP
rs967984113 466 dbSNP
rs1191795721 475 dbSNP
rs934541962 486 dbSNP
rs924505076 487 dbSNP
rs189577655 496 dbSNP
rs1392171291 498 dbSNP
rs1379462458 502 dbSNP
rs1334754054 503 dbSNP
rs1299303617 508 dbSNP
rs1359375105 526 dbSNP
rs1397513990 539 dbSNP
rs1009555711 540 dbSNP
rs1355681860 543 dbSNP
rs933327176 544 dbSNP
rs1282177830 546 dbSNP
rs1405187592 553 dbSNP
rs1173091306 563 dbSNP
rs1285143812 565 dbSNP
rs1352521800 565 dbSNP
rs1488008233 565 dbSNP
rs796629751 565 dbSNP
rs1467579550 566 dbSNP
rs1214540582 569 dbSNP
rs892368143 570 dbSNP
rs1180882849 574 dbSNP
rs974815182 574 dbSNP
rs1439888717 577 dbSNP
rs1187333390 585 dbSNP
rs964772615 586 dbSNP
rs1034921477 589 dbSNP
rs572919439 597 dbSNP
rs1159787388 599 dbSNP
rs1360441902 605 dbSNP
rs1016356320 607 dbSNP
rs147206114 608 dbSNP
rs950907163 609 dbSNP
rs1395120089 615 dbSNP
rs1331732420 619 dbSNP
rs1337323484 631 dbSNP
rs905038378 632 dbSNP
rs1026553052 633 dbSNP
rs1351401896 637 dbSNP
rs1238122297 641 dbSNP
rs1282533111 647 dbSNP
rs761270694 655 dbSNP
rs1003577735 656 dbSNP
rs1044784948 657 dbSNP
rs1254273600 663 dbSNP
rs941109103 664 dbSNP
rs888232985 670 dbSNP
rs1380275510 674 dbSNP
rs1438345635 688 dbSNP
rs1176032949 693 dbSNP
rs1240263589 698 dbSNP
rs1170448403 699 dbSNP
rs1398184324 723 dbSNP
rs1447320513 726 dbSNP
rs1330400225 734 dbSNP
rs1443059950 747 dbSNP
rs143737763 759 dbSNP
rs1312864556 764 dbSNP
rs1232613913 783 dbSNP
rs929652849 788 dbSNP
rs1320238409 789 dbSNP
rs772591656 789 dbSNP
rs892910103 791 dbSNP
rs148446115 795 dbSNP
rs569709355 806 dbSNP
rs1196068381 809 dbSNP
rs1268584291 810 dbSNP
rs1432162534 821 dbSNP
rs548379740 823 dbSNP
rs976755221 826 dbSNP
rs1374486211 828 dbSNP
rs1465791073 831 dbSNP
rs536320948 833 dbSNP
rs184280389 835 dbSNP
rs35199157 838 dbSNP
rs192306731 840 dbSNP
rs1386330029 841 dbSNP
rs968094476 853 dbSNP
rs77082677 854 dbSNP
rs988081951 856 dbSNP
rs1257599720 862 dbSNP
rs1316449935 864 dbSNP
rs1381718209 871 dbSNP
rs956721834 872 dbSNP
rs1039022944 873 dbSNP
rs1443703341 877 dbSNP
rs1237537693 878 dbSNP
rs943431374 881 dbSNP
rs909280478 885 dbSNP
rs1034915074 886 dbSNP
rs1477836443 891 dbSNP
rs984867948 899 dbSNP
rs1003877015 905 dbSNP
rs1165184484 908 dbSNP
rs904986383 908 dbSNP
rs981684438 909 dbSNP
rs1023886587 910 dbSNP
rs1290508107 910 dbSNP
rs1362552654 911 dbSNP
rs1022606127 912 dbSNP
rs199672577 912 dbSNP
rs1230437478 913 dbSNP
rs1217746609 919 dbSNP
rs1489476952 920 dbSNP
rs1313844798 923 dbSNP
rs1321455719 923 dbSNP
rs1491540346 923 dbSNP
rs928599690 923 dbSNP
rs1325827851 924 dbSNP
rs1484009881 924 dbSNP
rs1491234112 924 dbSNP
rs1290122475 926 dbSNP
rs1412823765 928 dbSNP
rs1421772701 934 dbSNP
rs1245498126 935 dbSNP
rs1360494906 936 dbSNP
rs1045719908 944 dbSNP
rs1225372374 947 dbSNP
rs1012570337 948 dbSNP
rs186907218 955 dbSNP
rs9859377 961 dbSNP
rs1032755257 972 dbSNP
rs888180591 977 dbSNP
rs1378924761 979 dbSNP
rs1226899370 980 dbSNP
rs902975555 984 dbSNP
rs1400314568 987 dbSNP
rs779255583 991 dbSNP
rs929602073 992 dbSNP
rs900848067 996 dbSNP
rs1051378028 998 dbSNP
rs1040594194 999 dbSNP
rs1180260329 1000 dbSNP
rs1334543075 1000 dbSNP
rs998083326 1010 dbSNP
rs1156723634 1013 dbSNP
rs1423581239 1015 dbSNP
rs1378572264 1018 dbSNP
rs899763965 1031 dbSNP
rs565976764 1032 dbSNP
rs543237674 1033 dbSNP
rs534532720 1036 dbSNP
rs1446361179 1042 dbSNP
rs574433512 1043 dbSNP
rs1378053847 1044 dbSNP
rs559531959 1052 dbSNP
rs764194538 1053 dbSNP
rs755101727 1058 dbSNP
rs1219301142 1059 dbSNP
rs753638217 1060 dbSNP
rs1372940003 1061 dbSNP
rs1200351399 1064 dbSNP
rs1258505399 1065 dbSNP
rs1457115590 1072 dbSNP
rs766122158 1076 dbSNP
rs866886065 1092 dbSNP
rs946908976 1094 dbSNP
rs1267179558 1104 dbSNP
rs915300490 1111 dbSNP
rs988197945 1112 dbSNP
rs956670913 1122 dbSNP
rs760628964 1123 dbSNP
rs1452362290 1129 dbSNP
rs982173544 1129 dbSNP
rs1401494336 1130 dbSNP
rs541024949 1131 dbSNP
rs1465369760 1145 dbSNP
rs184854218 1148 dbSNP
rs1338831848 1149 dbSNP
rs1005367348 1157 dbSNP
rs916135957 1158 dbSNP
rs991775280 1172 dbSNP
rs952538024 1185 dbSNP
rs1025366264 1186 dbSNP
rs1342346123 1192 dbSNP
rs374440523 1195 dbSNP
rs1032680241 1196 dbSNP
rs977134570 1212 dbSNP
rs1292014479 1225 dbSNP
rs71322404 1228 dbSNP
rs750411192 1229 dbSNP
rs1407923790 1237 dbSNP
rs1395122759 1238 dbSNP
rs1029473598 1242 dbSNP
rs1479461857 1246 dbSNP
rs760719593 1248 dbSNP
rs1424600242 1249 dbSNP
rs369186855 1252 dbSNP
rs1479069175 1256 dbSNP
rs1006584269 1257 dbSNP
rs192568902 1261 dbSNP
rs1393566173 1272 dbSNP
rs1406493409 1276 dbSNP
rs1478567654 1276 dbSNP
rs1018138095 1302 dbSNP
rs1248605146 1309 dbSNP
rs1401226967 1311 dbSNP
rs1278523227 1313 dbSNP
rs889346276 1318 dbSNP
rs1005463126 1322 dbSNP
rs1216626311 1324 dbSNP
rs187428907 1326 dbSNP
rs1356724835 1335 dbSNP
rs1050716972 1347 dbSNP
rs1227682044 1350 dbSNP
rs1287556454 1355 dbSNP
rs375680967 1360 dbSNP
rs1218870156 1363 dbSNP
rs1264229042 1366 dbSNP
rs915417058 1378 dbSNP
rs1052429841 1380 dbSNP
rs1191253510 1384 dbSNP
rs775916285 1385 dbSNP
rs928104731 1392 dbSNP
rs929385623 1396 dbSNP
rs1163193873 1403 dbSNP
rs576308084 1407 dbSNP
rs1298253163 1408 dbSNP
rs1359550732 1409 dbSNP
rs969434848 1418 dbSNP
rs916455419 1420 dbSNP
rs950258198 1425 dbSNP
rs984047222 1431 dbSNP
rs1340844737 1442 dbSNP
rs1243786224 1459 dbSNP
rs1282414826 1469 dbSNP
rs916121633 1470 dbSNP
rs1242454839 1471 dbSNP
rs952486585 1484 dbSNP
rs1200645941 1486 dbSNP
rs1025482713 1498 dbSNP
rs554445354 1499 dbSNP
rs536477589 1502 dbSNP
rs1203629100 1523 dbSNP
rs936245131 1526 dbSNP
rs925580824 1528 dbSNP
rs1218371050 1538 dbSNP
rs1019380729 1539 dbSNP
rs1006942510 1544 dbSNP
rs889470077 1550 dbSNP
rs1159740442 1554 dbSNP
rs967091347 1555 dbSNP
rs1276454202 1556 dbSNP
rs1029810891 1557 dbSNP
rs1439538021 1567 dbSNP
rs565823719 1569 dbSNP
rs1432399149 1576 dbSNP
rs201294796 1579 dbSNP
rs1395289739 1584 dbSNP
rs1331386417 1592 dbSNP
rs370217356 1599 dbSNP
rs1404466361 1600 dbSNP
rs115499559 1612 dbSNP
rs571275804 1614 dbSNP
rs935538278 1616 dbSNP
rs1447453087 1618 dbSNP
rs1415611778 1620 dbSNP
rs1427685722 1623 dbSNP
rs1335252544 1625 dbSNP
rs550172822 1632 dbSNP
rs928014691 1639 dbSNP
rs1046490299 1643 dbSNP
rs948015910 1648 dbSNP
rs1261700116 1651 dbSNP
rs1180539898 1653 dbSNP
rs1179814383 1658 dbSNP
rs916589965 1662 dbSNP
rs1238096353 1663 dbSNP
rs984161777 1666 dbSNP
rs183455022 1667 dbSNP
rs1025542889 1675 dbSNP
rs931213544 1688 dbSNP
rs918538122 1690 dbSNP
rs567987014 1697 dbSNP
rs1460049928 1698 dbSNP
rs144559164 1699 dbSNP
rs965256953 1702 dbSNP
rs1019752271 1712 dbSNP
rs149305076 1713 dbSNP
rs1312748694 1716 dbSNP
rs1330673997 1728 dbSNP
rs985233609 1730 dbSNP
rs953802877 1731 dbSNP
rs1046230700 1738 dbSNP
rs1021242037 1747 dbSNP
rs1331718478 1748 dbSNP
rs1011230568 1754 dbSNP
rs894612795 1755 dbSNP
rs191269482 1761 dbSNP
rs1309548871 1768 dbSNP
rs1251291041 1772 dbSNP
rs936214071 1780 dbSNP
rs926174094 1784 dbSNP
rs1379934896 1787 dbSNP
rs1432035095 1788 dbSNP
rs1196841968 1790 dbSNP
rs1031232485 1796 dbSNP
rs1000073416 1801 dbSNP
rs906710526 1812 dbSNP
rs369917924 1813 dbSNP
rs1046880869 1815 dbSNP
rs948160802 1825 dbSNP
rs945694179 1828 dbSNP
rs1459411671 1831 dbSNP
rs1316631456 1833 dbSNP
rs922329966 1836 dbSNP
rs138435202 1840 dbSNP
rs1530640 1844 dbSNP
rs1442950118 1846 dbSNP
rs1301584657 1848 dbSNP
rs187934886 1848 dbSNP
rs918480910 1852 dbSNP
rs1306077650 1861 dbSNP
rs773911655 1861 dbSNP
rs1247642302 1866 dbSNP
rs1266481481 1873 dbSNP
rs1490062891 1876 dbSNP
rs1219607450 1879 dbSNP
rs972656871 1880 dbSNP
rs895182128 1881 dbSNP
rs1192434040 1883 dbSNP
rs1443085624 1887 dbSNP
rs1311827384 1891 dbSNP
rs1165472965 1896 dbSNP
rs1384659762 1898 dbSNP
rs543433133 1907 dbSNP
rs551825539 1908 dbSNP
rs1362494022 1911 dbSNP
rs183444060 1913 dbSNP
rs1400863103 1914 dbSNP
rs532095977 1919 dbSNP
rs113276702 1920 dbSNP
rs1286554418 1921 dbSNP
rs1391477785 1922 dbSNP
rs1165692051 1923 dbSNP
rs531300611 1923 dbSNP
rs554885842 1924 dbSNP
rs1241854272 1925 dbSNP
rs144715027 1928 dbSNP
rs1356893268 1929 dbSNP
rs1243196501 1931 dbSNP
rs1311348069 1931 dbSNP
rs527618025 1931 dbSNP
rs1287584259 1933 dbSNP
rs1353747273 1935 dbSNP
rs953813257 1949 dbSNP
rs1021358260 1952 dbSNP
rs1214654994 1952 dbSNP
rs189616546 1961 dbSNP
rs955719771 1963 dbSNP
rs1399714038 1970 dbSNP
rs1442734424 1976 dbSNP
rs1361572398 1979 dbSNP
rs1031180197 1985 dbSNP
rs999785138 1992 dbSNP
rs553568610 1993 dbSNP
rs1158740498 1997 dbSNP
rs771368930 1999 dbSNP
rs747843982 2000 dbSNP
rs1303761498 2002 dbSNP
rs1025134892 2003 dbSNP
rs747353735 2005 dbSNP
rs895216072 2006 dbSNP
rs142349895 2011 dbSNP
rs552617639 2016 dbSNP
rs1313554643 2019 dbSNP
rs1210331600 2024 dbSNP
rs897165254 2032 dbSNP
rs9834133 2033 dbSNP
rs1180436871 2034 dbSNP
rs1263604164 2042 dbSNP
rs943965474 2043 dbSNP
rs1238709307 2044 dbSNP
rs1489697245 2047 dbSNP
rs1176669758 2049 dbSNP
rs1406115553 2051 dbSNP
rs1264515725 2053 dbSNP
rs185197231 2054 dbSNP
rs1405830567 2062 dbSNP
rs1468508773 2066 dbSNP
rs1334014010 2071 dbSNP
rs1401628429 2074 dbSNP
rs1323009363 2075 dbSNP
rs1292909122 2076 dbSNP
rs1049567354 2077 dbSNP
rs7652315 2085 dbSNP
rs1277295504 2087 dbSNP
rs1341720897 2087 dbSNP
rs914294878 2094 dbSNP
rs1403511209 2096 dbSNP
rs1367100247 2097 dbSNP
rs989867095 2106 dbSNP
rs1459701267 2115 dbSNP
rs1352824691 2131 dbSNP
rs755225718 2132 dbSNP
rs1465009627 2145 dbSNP
rs1258688147 2151 dbSNP
rs924279152 2154 dbSNP
rs1437132354 2156 dbSNP
rs1269988839 2164 dbSNP
rs1424288113 2168 dbSNP
rs1202308738 2175 dbSNP
rs1231277705 2179 dbSNP
rs1195517391 2186 dbSNP
rs1449311033 2189 dbSNP
rs981550873 2191 dbSNP
rs970993354 2192 dbSNP
rs1200424980 2199 dbSNP
rs1428860248 2201 dbSNP
rs1479686861 2205 dbSNP
rs1025674926 2206 dbSNP
rs1173229544 2215 dbSNP
rs1420613624 2222 dbSNP
rs549607510 2223 dbSNP
rs959539320 2225 dbSNP
rs1027035543 2226 dbSNP
rs1327369795 2234 dbSNP
rs995591616 2235 dbSNP
rs1042356780 2238 dbSNP
rs528001116 2245 dbSNP
rs1220283353 2257 dbSNP
rs1278644091 2258 dbSNP
rs1338454151 2266 dbSNP
rs1489293530 2269 dbSNP
rs1291860830 2270 dbSNP
rs922234460 2270 dbSNP
rs1040736209 2282 dbSNP
rs1223284382 2285 dbSNP
rs1037026756 2299 dbSNP
rs1268491843 2302 dbSNP
rs1008673153 2307 dbSNP
rs1489929226 2309 dbSNP
rs1243066975 2311 dbSNP
rs748804670 2311 dbSNP
rs1166729107 2313 dbSNP
rs569068421 2313 dbSNP
rs891027017 2316 dbSNP
rs1416573440 2318 dbSNP
rs1050121165 2320 dbSNP
rs910960802 2321 dbSNP
rs932453456 2328 dbSNP
rs567034329 2329 dbSNP
rs1342776504 2332 dbSNP
rs1221993259 2333 dbSNP
rs1332834814 2342 dbSNP
rs754010334 2348 dbSNP
rs952545542 2349 dbSNP
rs1428383908 2353 dbSNP
rs918430672 2354 dbSNP
rs1356920253 2362 dbSNP
rs973028334 2371 dbSNP
rs970681525 2380 dbSNP
rs780235509 2382 dbSNP
rs1357295863 2397 dbSNP
rs141445110 2400 dbSNP
rs1262690256 2401 dbSNP
rs1191457143 2412 dbSNP
rs1330716558 2415 dbSNP
rs1239764062 2419 dbSNP
rs1445800272 2428 dbSNP
rs1183468261 2453 dbSNP
rs60083169 2454 dbSNP
rs369436709 2456 dbSNP
rs934404423 2464 dbSNP
rs924385195 2465 dbSNP
rs1400871333 2469 dbSNP
rs750212954 2474 dbSNP
rs971490957 2484 dbSNP
rs57096170 2495 dbSNP
rs1335965228 2505 dbSNP
rs1383189170 2507 dbSNP
rs904650756 2510 dbSNP
rs991076090 2511 dbSNP
rs1242388902 2518 dbSNP
rs60878258 2519 dbSNP
rs1027151979 2530 dbSNP
rs1376846864 2538 dbSNP
rs1176588711 2543 dbSNP
rs1281197477 2545 dbSNP
rs183113064 2556 dbSNP
rs751083801 2562 dbSNP
rs1010882560 2585 dbSNP
rs769650935 2590 dbSNP
rs1241833910 2591 dbSNP
rs1412358549 2598 dbSNP
rs1441068759 2605 dbSNP
rs1181883419 2608 dbSNP
rs745834918 2618 dbSNP
rs995708426 2619 dbSNP
rs151083125 2620 dbSNP
rs560722040 2632 dbSNP
rs190977977 2635 dbSNP
rs1202317550 2638 dbSNP
rs1344983948 2640 dbSNP
rs762712975 2642 dbSNP
rs1256924779 2652 dbSNP
rs910926648 2653 dbSNP
rs143753735 2659 dbSNP
rs931074087 2661 dbSNP
rs918385854 2674 dbSNP
rs1285365163 2688 dbSNP
rs35470333 2689 dbSNP
rs891128810 2698 dbSNP
rs949265460 2699 dbSNP
rs1261854834 2701 dbSNP
rs1459499570 2703 dbSNP
rs1196849762 2716 dbSNP
rs775328279 2734 dbSNP
rs990767035 2735 dbSNP
rs958690983 2741 dbSNP
rs1200629505 2743 dbSNP
rs1034351401 2747 dbSNP
rs185677539 2750 dbSNP
rs1480011230 2751 dbSNP
rs757085130 2754 dbSNP
rs148990967 2757 dbSNP
rs1020812693 2770 dbSNP
rs893090748 2775 dbSNP
rs1401444899 2776 dbSNP
rs1303160869 2779 dbSNP
rs1297467626 2780 dbSNP
rs577706842 2783 dbSNP
rs1378025574 2787 dbSNP
rs1389725894 2788 dbSNP
rs556668360 2790 dbSNP
rs145758777 2796 dbSNP
rs1223327240 2798 dbSNP
rs549155903 2803 dbSNP
rs902911641 2805 dbSNP
rs1309567163 2810 dbSNP
rs567610787 2812 dbSNP
rs1228814468 2819 dbSNP
rs1381602356 2827 dbSNP
rs181749518 2837 dbSNP
rs1211077301 2842 dbSNP
rs1269216552 2851 dbSNP
rs1045901640 2852 dbSNP
rs1196785943 2867 dbSNP
rs1265063996 2868 dbSNP
rs1442310201 2874 dbSNP
rs1169721763 2881 dbSNP
rs949709929 2884 dbSNP
rs889416428 2891 dbSNP
rs1460560848 2899 dbSNP
rs1165519004 2905 dbSNP
rs534464202 2908 dbSNP
rs915563266 2909 dbSNP
rs567197966 2910 dbSNP
rs991190810 2919 dbSNP
rs1301466461 2921 dbSNP
rs1364599313 2922 dbSNP
rs1202484934 2927 dbSNP
rs1048064161 2930 dbSNP
rs1383124876 2930 dbSNP
rs1306247872 2935 dbSNP
rs938235091 2936 dbSNP
rs1248744440 2938 dbSNP
rs931039919 2941 dbSNP
rs896883532 2948 dbSNP
rs1037216752 2962 dbSNP
rs920203647 2972 dbSNP
rs1185679875 2975 dbSNP
rs974219915 2976 dbSNP
rs1425505464 2979 dbSNP
rs1184059823 2981 dbSNP
rs1385962195 2981 dbSNP
rs190425523 2982 dbSNP
rs990693522 2983 dbSNP
rs1454678832 2988 dbSNP
rs961861454 2996 dbSNP
rs540079834 3003 dbSNP
rs987293554 3008 dbSNP
rs186272219 3012 dbSNP
rs530495602 3018 dbSNP
rs1308743393 3021 dbSNP
rs1317112368 3023 dbSNP
rs1020362856 3033 dbSNP
rs773394353 3035 dbSNP
rs1244182709 3038 dbSNP
rs1028734909 3039 dbSNP
rs368718331 3040 dbSNP
rs1397780160 3042 dbSNP
rs1444129964 3042 dbSNP
rs1180170886 3052 dbSNP
rs893038507 3057 dbSNP
rs1410191512 3058 dbSNP
rs1158570275 3059 dbSNP
rs1343815993 3063 dbSNP
rs1358374134 3070 dbSNP
rs748567435 3071 dbSNP
rs1007069191 3076 dbSNP
rs998619402 3084 dbSNP
rs755243638 3089 dbSNP
rs1299402947 3093 dbSNP
rs903021966 3097 dbSNP
rs1222868768 3103 dbSNP
rs1027216948 3112 dbSNP
rs1045443429 3119 dbSNP
rs1325504353 3123 dbSNP
rs949835408 3125 dbSNP
rs894258393 3131 dbSNP
rs144721659 3139 dbSNP
rs1055454800 3140 dbSNP
rs774513041 3155 dbSNP
rs1206489962 3162 dbSNP
rs1234677775 3172 dbSNP
rs930318759 3189 dbSNP
rs1362101178 3199 dbSNP
rs920151492 3202 dbSNP
rs1410026200 3210 dbSNP
rs974334682 3214 dbSNP
rs1177570729 3219 dbSNP
rs940165366 3221 dbSNP
rs908701257 3222 dbSNP
rs987021499 3224 dbSNP
rs955630368 3236 dbSNP
rs896847828 3238 dbSNP
rs1468728372 3240 dbSNP
rs1331397980 3242 dbSNP
rs1036777722 3249 dbSNP
rs1346983996 3250 dbSNP
rs1440835391 3250 dbSNP
rs750277918 3250 dbSNP
rs1405128593 3255 dbSNP
rs1369486397 3264 dbSNP
rs1028390270 3274 dbSNP
rs1321068827 3278 dbSNP
rs975363589 3279 dbSNP
rs78706800 3283 dbSNP
rs564701942 3284 dbSNP
rs1054977837 3290 dbSNP
rs1217864108 3291 dbSNP
rs1489363447 3292 dbSNP
rs4686788 3295 dbSNP
rs572839782 3296 dbSNP
rs527566572 3297 dbSNP
rs1170219281 3305 dbSNP
rs1014116057 3307 dbSNP
rs1267364506 3308 dbSNP
rs1420812129 3309 dbSNP
rs1246868859 3311 dbSNP
rs756315129 3315 dbSNP
rs1166198921 3322 dbSNP
rs560056560 3334 dbSNP
rs201210321 3341 dbSNP
rs764284320 3349 dbSNP
rs1302080313 3351 dbSNP
rs113714120 3352 dbSNP
rs1432632354 3359 dbSNP
rs1270737663 3364 dbSNP
rs1361155587 3366 dbSNP
rs1277288792 3370 dbSNP
rs898834794 3373 dbSNP
rs1212682181 3375 dbSNP
rs1272608283 3382 dbSNP
rs1361592674 3383 dbSNP
rs1223583789 3385 dbSNP
rs577721916 3387 dbSNP
rs940258955 3390 dbSNP
rs908821442 3393 dbSNP
rs1195755709 3399 dbSNP
rs1243009463 3414 dbSNP
rs1051680897 3418 dbSNP
rs913229438 3424 dbSNP
rs934192434 3432 dbSNP
rs921317478 3434 dbSNP
rs975474703 3439 dbSNP
rs1321184701 3442 dbSNP
rs957331156 3443 dbSNP
rs912708440 3445 dbSNP
rs1404470179 3449 dbSNP
rs925954971 3457 dbSNP
rs867491825 3458 dbSNP
rs1344343624 3462 dbSNP
rs139188221 3468 dbSNP
rs745686702 3470 dbSNP
rs544660633 3471 dbSNP
rs1024250625 3472 dbSNP
rs181534127 3474 dbSNP
rs1014481806 3475 dbSNP
rs1207080994 3478 dbSNP
rs1285402509 3480 dbSNP
rs1198405020 3490 dbSNP
rs1252649601 3500 dbSNP
rs1452456200 3502 dbSNP
rs1292075280 3504 dbSNP
rs1196864087 3505 dbSNP
rs555708544 3511 dbSNP
rs1013307256 3512 dbSNP
rs1218946177 3513 dbSNP
rs1158715790 3516 dbSNP
rs534215929 3517 dbSNP
rs1338671132 3518 dbSNP
rs1406706662 3520 dbSNP
rs1341207565 3521 dbSNP
rs573564927 3522 dbSNP
rs1486818692 3525 dbSNP
rs111829280 3526 dbSNP
rs1435286211 3526 dbSNP
rs1265592081 3528 dbSNP
rs1462171383 3531 dbSNP
rs1203541378 3539 dbSNP
rs1253464806 3542 dbSNP
rs1438981062 3542 dbSNP
rs1029769987 3544 dbSNP
rs1182147949 3544 dbSNP
rs1272645963 3544 dbSNP
rs1362832788 3544 dbSNP
rs1371256821 3544 dbSNP
rs1471517086 3544 dbSNP
rs574168560 3544 dbSNP
rs1043611673 3547 dbSNP
rs1324912843 3549 dbSNP
rs1350076529 3551 dbSNP
rs1408178811 3556 dbSNP
rs558535488 3563 dbSNP
rs1285617757 3567 dbSNP
rs945296825 3588 dbSNP
rs958541120 3589 dbSNP
rs1233173397 3591 dbSNP
rs1034066515 3601 dbSNP
rs374358330 3602 dbSNP
rs150807188 3603 dbSNP
rs780784347 3607 dbSNP
rs1269350480 3613 dbSNP
rs766514367 3615 dbSNP
rs1172002712 3617 dbSNP
rs757249778 3619 dbSNP
rs985541956 3629 dbSNP
rs1168591666 3630 dbSNP
rs1369981065 3634 dbSNP
rs1428065625 3636 dbSNP
rs1305121037 3648 dbSNP
rs1346599733 3660 dbSNP
rs1004575089 3696 dbSNP
rs1299883341 3700 dbSNP
rs954206427 3702 dbSNP
rs1228749855 3718 dbSNP
rs751400932 3720 dbSNP
rs1172398995 3730 dbSNP
rs552699909 3734 dbSNP
rs28575058 3738 dbSNP
rs1490136934 3741 dbSNP
rs934116461 3750 dbSNP
rs573908755 3753 dbSNP
rs148676892 3760 dbSNP
rs548560570 3766 dbSNP
rs1457374474 3775 dbSNP
rs1238941630 3783 dbSNP
rs1039890943 3785 dbSNP
rs961942947 3816 dbSNP
rs1389642334 3820 dbSNP
rs936081263 3824 dbSNP
rs1276208418 3831 dbSNP
rs926069352 3833 dbSNP
rs1218464534 3843 dbSNP
rs1345230588 3848 dbSNP
rs1013658174 3852 dbSNP
rs1292183050 3856 dbSNP
rs145955642 3861 dbSNP
rs1033426641 3862 dbSNP
rs1297492922 3869 dbSNP
rs1362488571 3870 dbSNP
rs977807939 3888 dbSNP
rs1315365838 3891 dbSNP
rs1320765280 3893 dbSNP
rs1001957442 3894 dbSNP
rs1246108038 3894 dbSNP
rs1262274175 3894 dbSNP
rs201432633 3894 dbSNP
rs967423805 3902 dbSNP
rs1331495328 3904 dbSNP
rs1385900601 3908 dbSNP
rs1423470476 3931 dbSNP
rs1444950479 3934 dbSNP
rs559724181 3939 dbSNP
rs992767008 3940 dbSNP
rs1415417870 3941 dbSNP
rs1387064680 3954 dbSNP
rs958650438 3954 dbSNP
rs1034176243 3955 dbSNP
rs1009464936 3960 dbSNP
rs188153597 3962 dbSNP
rs1308673192 3970 dbSNP
rs533094855 3974 dbSNP
rs994701510 3976 dbSNP
rs1227519011 3977 dbSNP
rs760124603 3985 dbSNP
rs562676048 3989 dbSNP
rs1204150711 3991 dbSNP
rs1180635430 3996 dbSNP
rs751020065 4005 dbSNP
rs1482960010 4008 dbSNP
rs1004924941 4015 dbSNP
rs544103339 4025 dbSNP
rs1049758320 4028 dbSNP
rs1442781608 4031 dbSNP
rs1282270263 4032 dbSNP
rs1030285641 4066 dbSNP
rs998393395 4075 dbSNP
rs1445162112 4080 dbSNP
rs1299564715 4085 dbSNP
rs900129365 4085 dbSNP
rs78868159 4092 dbSNP
rs974665253 4093 dbSNP
rs562201703 4105 dbSNP
rs940225951 4107 dbSNP
rs936198525 4116 dbSNP
rs908780152 4117 dbSNP
rs992463452 4120 dbSNP
rs904593932 4121 dbSNP
rs1224989319 4131 dbSNP
rs1253105085 4147 dbSNP
rs557199706 4148 dbSNP
rs1483521415 4150 dbSNP
rs764998237 4151 dbSNP
rs1250081610 4152 dbSNP
rs1481615444 4161 dbSNP
rs1192348694 4168 dbSNP
rs1284131803 4174 dbSNP
rs1449492167 4182 dbSNP
rs759202722 4183 dbSNP
rs1296792691 4184 dbSNP
rs967810685 4185 dbSNP
rs1354551495 4190 dbSNP
rs946004497 4196 dbSNP
rs538800941 4206 dbSNP
rs1347241404 4208 dbSNP
rs1160485706 4209 dbSNP
rs375798606 4215 dbSNP
rs892332374 4217 dbSNP
rs1365436495 4220 dbSNP
rs774691139 4224 dbSNP
rs1019274947 4230 dbSNP
rs1297820696 4234 dbSNP
rs1342885965 4237 dbSNP
rs558192622 4241 dbSNP
rs1272743986 4243 dbSNP
rs1490953425 4251 dbSNP
rs371851029 4251 dbSNP
rs937227719 4255 dbSNP
rs1246439542 4258 dbSNP
rs540102565 4269 dbSNP
rs973208573 4270 dbSNP
rs1390316018 4275 dbSNP
rs1448349035 4279 dbSNP
rs963219250 4280 dbSNP
rs1166372578 4281 dbSNP
rs1259313983 4285 dbSNP
rs1191273864 4296 dbSNP
rs1049729388 4298 dbSNP
rs961323532 4300 dbSNP
rs372811749 4301 dbSNP
rs1322688157 4302 dbSNP
rs74998089 4318 dbSNP
rs1016852671 4320 dbSNP
rs1227714892 4320 dbSNP
rs1270682906 4320 dbSNP
rs1352400093 4320 dbSNP
rs1366106590 4320 dbSNP
rs1432822660 4320 dbSNP
rs1217227246 4323 dbSNP
rs1319401210 4325 dbSNP
rs932714278 4327 dbSNP
rs1386520740 4332 dbSNP
rs1327842930 4333 dbSNP
rs1288599918 4340 dbSNP
rs1162217806 4341 dbSNP
rs575877642 4346 dbSNP
rs4686430 4352 dbSNP
rs1387786267 4358 dbSNP
rs1432744600 4359 dbSNP
rs983222358 4362 dbSNP
rs1357961298 4364 dbSNP
rs1449108506 4365 dbSNP
rs1276657979 4366 dbSNP
rs1399807797 4367 dbSNP
rs1283818834 4370 dbSNP
rs578218164 4371 dbSNP
rs1225810055 4372 dbSNP
rs535710979 4374 dbSNP
rs995828890 4379 dbSNP
rs900076984 4382 dbSNP
rs894931763 4386 dbSNP
rs1018501519 4387 dbSNP
rs1000291949 4391 dbSNP
rs1442482913 4392 dbSNP
rs904697585 4394 dbSNP
rs1235352256 4395 dbSNP
rs374864807 4402 dbSNP
rs946143971 4403 dbSNP
rs763397509 4406 dbSNP
rs1455580173 4409 dbSNP
rs866190477 4412 dbSNP
rs1461857543 4415 dbSNP
rs895916725 4420 dbSNP
rs1057135187 4421 dbSNP
rs1333814100 4424 dbSNP
rs937342172 4426 dbSNP
rs908713341 4434 dbSNP
rs1289381065 4436 dbSNP
rs555000518 4442 dbSNP
rs1350191378 4443 dbSNP
rs927164872 4445 dbSNP
rs762215480 4446 dbSNP
rs941801252 4448 dbSNP
rs557852636 4450 dbSNP
rs907695734 4451 dbSNP
rs939599646 4458 dbSNP
rs983726186 4459 dbSNP
rs1182366310 4462 dbSNP
rs954474881 4463 dbSNP
rs533652793 4464 dbSNP
rs1201556339 4466 dbSNP
rs1245595131 4477 dbSNP
rs1465445304 4481 dbSNP
rs974358524 4483 dbSNP
rs964361087 4486 dbSNP
rs967736824 4496 dbSNP
rs1018449110 4504 dbSNP
rs1000407555 4505 dbSNP
rs1256737004 4511 dbSNP
rs1022453925 4516 dbSNP
rs1408350458 4519 dbSNP
rs987945383 4521 dbSNP
rs183881141 4524 dbSNP
rs1233109562 4525 dbSNP
rs1272575716 4528 dbSNP
rs1343604365 4531 dbSNP
rs1385288853 4538 dbSNP
rs192370089 4539 dbSNP
rs533231571 4545 dbSNP
rs1010844669 4546 dbSNP
rs1224479040 4550 dbSNP
rs569089346 4554 dbSNP
rs1432531689 4555 dbSNP
rs1443206585 4564 dbSNP
rs137866185 4568 dbSNP
rs145270432 4569 dbSNP
rs386669181 4570 dbSNP
rs1451401361 4576 dbSNP
rs1465099588 4581 dbSNP
rs1373398661 4582 dbSNP
rs540690093 4583 dbSNP
rs1391822009 4586 dbSNP
rs1008739754 4592 dbSNP
rs570219630 4593 dbSNP
rs1322143773 4598 dbSNP
rs1424064954 4605 dbSNP
rs905863234 4610 dbSNP
rs528611190 4611 dbSNP
rs1296164755 4614 dbSNP
rs1339678280 4616 dbSNP
rs1469426443 4621 dbSNP
rs1246451223 4625 dbSNP
rs941948568 4626 dbSNP
rs1488029174 4628 dbSNP
rs1235904107 4642 dbSNP
rs1263722243 4643 dbSNP
rs73055399 4647 dbSNP
rs545913170 4651 dbSNP
rs1189315416 4659 dbSNP
rs575886245 4661 dbSNP
rs1047540039 4662 dbSNP
rs898536638 4669 dbSNP
rs749426104 4670 dbSNP
rs1038821791 4673 dbSNP
rs1004308239 4679 dbSNP
rs1436414124 4681 dbSNP
rs887245453 4684 dbSNP
rs1056667252 4689 dbSNP
rs1397478424 4690 dbSNP
rs557417017 4694 dbSNP
rs974473348 4696 dbSNP
rs542512939 4698 dbSNP
rs1045377758 4700 dbSNP
rs946371492 4706 dbSNP
rs1236843166 4711 dbSNP
rs1035145433 4719 dbSNP
rs1247504841 4723 dbSNP
rs4686787 4724 dbSNP
rs1183860530 4726 dbSNP
rs1257099669 4730 dbSNP
rs1423414943 4739 dbSNP
rs553168364 4750 dbSNP
rs911702579 4760 dbSNP
rs1299627282 4766 dbSNP
rs1458245772 4767 dbSNP
rs189508283 4776 dbSNP
rs1385894963 4789 dbSNP
rs80323553 4796 dbSNP
rs1173857019 4808 dbSNP
rs1378014285 4811 dbSNP
rs1393886557 4812 dbSNP
rs1455340984 4814 dbSNP
rs549506938 4821 dbSNP
rs781059102 4841 dbSNP
rs1315254360 4846 dbSNP
rs779638724 4851 dbSNP
rs1377925969 4853 dbSNP
rs1177494641 4870 dbSNP
rs1256624705 4872 dbSNP
rs1420164933 4872 dbSNP
rs1483050914 4873 dbSNP
rs1186010456 4875 dbSNP
rs994717121 4879 dbSNP
rs1020972901 4881 dbSNP
rs775271550 4882 dbSNP
rs557313885 4884 dbSNP
rs1232496008 4885 dbSNP
rs1010374097 4886 dbSNP
rs1253294626 4888 dbSNP
rs1199035033 4902 dbSNP
rs1473122028 4909 dbSNP
rs1182136839 4922 dbSNP
rs963000274 4927 dbSNP
rs960490486 4938 dbSNP
rs1435370362 4945 dbSNP
rs1176191071 4951 dbSNP
rs539100328 4957 dbSNP
rs1358004500 4959 dbSNP
rs1035736301 4960 dbSNP
rs1464243236 4963 dbSNP
rs1001614252 4965 dbSNP
rs1309456697 4966 dbSNP
rs569127767 4968 dbSNP
rs1408970514 4969 dbSNP
rs1016949230 4972 dbSNP
rs905979148 4979 dbSNP
rs550551550 4982 dbSNP
rs185856938 4984 dbSNP
rs757047867 4987 dbSNP
rs80136319 4989 dbSNP
rs1003707408 4990 dbSNP
rs149253186 4998 dbSNP
rs905398321 5008 dbSNP
rs933135559 5016 dbSNP
rs1045301332 5020 dbSNP
rs1394274255 5025 dbSNP
rs1401201711 5031 dbSNP
rs1452025994 5042 dbSNP
rs1170135742 5045 dbSNP
rs1313315432 5048 dbSNP
rs1390430366 5051 dbSNP
rs528581980 5057 dbSNP
rs1428664901 5064 dbSNP
rs946994699 5065 dbSNP
rs923111781 5066 dbSNP
rs1038882657 5072 dbSNP
rs1351346778 5078 dbSNP
rs1437184008 5078 dbSNP
rs943115565 5080 dbSNP
rs1367050189 5081 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55171.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714646. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acggucggAGCGGGUCg 5'
                  |||||||| 
Target 5' uuguucugUCGCCCAGg 3'
 		8 - 24
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760631. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_B ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acggucggAGCGGGUCg 5'
                  |||||||| 
Target 5' uuguucugUCGCCCAG- 3'
 		8 - 23
Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_001134415 | 3UTR | GUUCUGUCGCCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001134415 | 3UTR | CCCAGGCUGGAGUGCAGUGGCGCGAUCUCGGCUCACUGCAAGCUCUGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGGACUACAGGCGCCCGCCACCACGCCCGGCCAAUUUUUUUUGUAUUUUUAGUAGAGACGGGGUUUCACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_018138 | 3UTR | UGUUCUGUCGCCCAGGCUGGAGUGCAGUGGCGCGAUCUCGGCUCACUGCAAGCUCUGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGGACUACAGGCGCCCGCCACCACGCCCGGCCAAUUUUUUUUGUAUUUUUAGUAGAGACGGGGUUUCACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001134415 | 3UTR | UCUUGUUCUGUCGCCCAGGCUGGAGUGCAGUGGCGCGAUCUCGGCUCACUGCAAGCUCUGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGGACUACAGGCGCCCGCCACCACGCCCGGCCAAUUUUUUUUGUAUUUUUAGUAGAGACGGGGUUUCACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_018138 | 3UTR | UGUUCUGUCGCCCAGGCUGGAGUGCAGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_018138 | 3UTR | UUGUUCUGUCGCCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001134415 | 3UTR | AGUCUUGUUCUGUCGCCCAGGCUGGAGUGCAGUGGCGCGAUCUCGGCUCACUGCAAGCUCUGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGGACUACAGGCGCCCGCCACCACGCCCGGCCAAUUUUUUUUGUAUUUUUAGUAGAGACGGGGUUUCACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM714646
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repA
Location of target site ENST00000424280.1 | 3UTR | CAGAGUCUUGUUCUGUCGCCCAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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