pre-miRNA Information | |
---|---|
pre-miRNA | hsa-mir-1185-1 |
Genomic Coordinates | chr14: 101042977 - 101043062 |
Synonyms | MIRN1185-1, hsa-mir-1185-1, MIR1185-1 |
Description | Homo sapiens miR-1185-1 stem-loop |
Comment | This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mature miRNA | hsa-miR-1185-1-3p | ||||||||||||||||||||||||||||||
Sequence | 53| AUAUACAGGGGGAGACUCUUAU |74 | ||||||||||||||||||||||||||||||
Evidence | Not_experimental | ||||||||||||||||||||||||||||||
Experiments | |||||||||||||||||||||||||||||||
Editing Events in miRNAs |
|
||||||||||||||||||||||||||||||
SNPs in miRNA |
|
||||||||||||||||||||||||||||||
Putative Targets |
miRNA Expression profile | |
---|---|
Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
|
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene Symbol | KCNK10 | ||||||||||||||||||||
Synonyms | K2p10.1, PPP1R97, TREK-2, TREK2 | ||||||||||||||||||||
Description | potassium two pore domain channel subfamily K member 10 | ||||||||||||||||||||
Transcript | NM_021161 | ||||||||||||||||||||
Other Transcripts | NM_138317 , NM_138318 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on KCNK10 | |||||||||||||||||||||
3'UTR of KCNK10 (miRNA target sites are highlighted) |
>KCNK10|NM_021161|3'UTR 1 ATGTGAAGGACATTGGTCTTGGACTGAGCGTTGTGTGTGTGTGTGTGTGTGTTTTTAATATTCACACTGAGACATGTGCC 81 TTAAACAGACTTTTTAGTCCAAAATTACATAGCATTGAAGAATATATTTCACTGTGCCATAAACAACTGAAAGCTTGCTC 161 TGCCAAAAGGAATCAGAGAACAAGAACTTCATTTCAGATAGCAAACGCAGGACACACCAAGAGTGTCCGTGCACGTAGCC 241 GGTTCTGGCCGTACATGTTAAGGGCATTTCAGTGGCAGTGCTGTACCCCTGGGCAGTGCTACCTGGGCACACACGTAGAC 321 AAGGGCAGCTATTCCTTAGACCAGCCTCCTGAAAGAAACAGGTGTGTCTTTTTAGTGGAGTCGTAGTAATATGTGCACAC 401 ACAGAAGGGGACCTGATTGGGTGGGAGCTGGTTATGTGTAACTAGCGTTGGAGTTGACATTTTGGCATGTGCTCTGAGCT 481 TGAATTTTGATACCAACCATTCAGTGCATCATACCTAGTCTTTCTATGCTCCAAATGAATGTCTGTGGGGACCTGAGAGC 561 ACCTGGAATTTGTTGGAAGCAGATCAGAGCACACGTACGAAAAGGTGCAATTGCTTTTCTCATGACAAAAGAAAAAAAAT 641 AATCACAAACACATCACACTGTGGATATCACCTTAACCAATGACAGAAGCCTGCTGAGTTTGGTCTTTCTCACAGGGGTA 721 GGTAGTCCACATGAACTGGCGAGCAGTGGTGAAAACATGACATCAACTGCTGCGTGGTTAAAGGCCAATCATGCATTTTC 801 CTCAGTGGGTGCAATGGTGACAATAAACTGATTTGGAAATGTCCATGTACTTTGGTTATAACTTGTTTTGATAAGAGGGG 881 TAGAAATACCAAAACAATTGCCTTGCATGATGCCAGTGGCTTGCTGTTCTGTCTAGCTGATCCTACATTTTTACAAAAGT 961 AGACATCCTGCATTTCTGAGACACACTGAGGAGGACCATGGCATCTTTCCATCTCAGGGCTTTTTGTCCCTTGGGTGTCT 1041 TAGGGTAGACATAGTGATAAGATCCAATCTCGCTATCTCCAAACAAAAAGAAAATGTACCCCTTGTACAGTAAGCTTGAA 1121 ATGTTTTTATTGCTTGCAGCGTAAGTGCCATTAATTCCATTTAACAATGATACTTAGAAATATTTAAAATATTTCATTTT 1201 ACTTTTATGTTTGGGCATTCCTTTATTCTGAAAAAGTCACCACTGCTCCTTGCTTGTTTCTACATCTCACATCGGTTACT 1281 CACTAAAACTGGAACACCCTAGACTGATTGTTCCCAGGCAAACGATAAGCTAACACATCATAATTATGATTGGTCTGTGA 1361 GGCTAGAACATCCCGCAGAGGAAAGTCGGGGAATGGCTAGTCATAGGTTGCATGATGATTTTAAATGGGTTTGTATCAGA 1441 AAGGGGAAAATACATACTCCTGTGTATGCCTCAGTCTTTATCATAATTGGCTGGTTCACAGCTAGCTCTTTGGGCCACAC 1521 GTGAAAGCATTTGGACCTGGCAACACCAGGCAGTTGCTGGTTATGGGTGTTCTAGGCTCACTGCTACCTTTTACAGAGTT 1601 CACGGGATTTTACGTAACTAACCCGCAGTGTGGATTTACCAAAAGATCACAGCACTAGCGGAGACTTCCAGAAACTGTCT 1681 CATGCTTTCTGACCTCCAGGGAAAGTTGTACCCACGACATCCTCAACCACTGGTACCATGGAAGACCTGTCCCTGCCCAT 1761 TTCTCAAAAATGCACAGCTCTTCCCTGCCTGGAGCACATGAAGTCCCATCTCCCTGTCCCCAGACCTTTAGGCTCTGTTG 1841 AAGTTCTGGCATTGCTTATGAGACCCTTCCTGTCCAAGGAAGGTCTAAGTCAACTCCTCCATTGGACTGGAGATGAGGCT 1921 CACTGGTGACATCCTGTGTCGACTCAGTAATAAATAGTCACTTGGGAGGCGATGTTTATGCAGGTGTGGATGTTGAGTTT 2001 TACTATGGGAATCATTCCAGCCTGACAAAATGTGTTTTAAGGAATAGGTAGATAACTGGGACTTCCTCTGTTATTCTAAC 2081 AAGTCGAAGCTTCCTAATTAAACTGTCCATGGATCTCACTTATTTGGTTTCCACTCTGTGTTATCTGGTACGTTCTTTGT 2161 AGCAGTGTGTTAAAATTCCAGGCCCTACGGCCAAATCTGGCAGAGGCTTCCCTCTCATTTATCCAGTGCCTTCTGTGGGC 2241 CAGGCACAGGATTAGGCACTTTATGAACGTCAGCTCATTGAAACTTCACGACACTATGTGGGAAGTATTTGCAAACCCAT 2321 TATATACACAAGGACACAGAGGCTCAGGGAAGCTATGTTATTTATCCAATGGCACACAGCAAGAAAGTGGTAGAGCTGGT 2401 ATTCAAAGTCTGACCAAAGTCTGCTTTCAACTTCACTACAGTGTCTGTGTCATGCATCCTTGTGATTGTGTGTGTTTGTG 2481 TGTATGTGTGTCTTTCTAGCTTCATGGACACAGCTTACAGATGTGGGGAGCAGATATGGTGGAATCTCCACCACCAAGAG 2561 GGCACAAGGTCTTTGTGTAAACATGGCTCAAAGGGTTGCCCCTGCAGACACCTACTGTACATTTATTTGGTTTTGGAAAT 2641 TTTGTATGTGGCACCCTTTAAAAAATGCCCTTTGAAAGCACTCTTTTGCACTTTACTTGCTAACTTTGTAGAAACTCTGC 2721 ATACAGCAGGAATAAAATAGTTCAAAGCACTAAGCTGCATACTCTACCAAATGGAACAGGTGCATGTGTTGGTATGTGCA 2801 TAGATGCTTCCCCAAATGAGTCAAATCAGTCACACAGAGGGATCAAACATAACCTTGGGCTGGGGGTGGGAAAATTTTCT 2881 ACATAACCCATTCCCTGAGACATTTGGCCAAGAATGTGATGAACAAAATCAAAGAAGATCCTCTATGGTGATTGATCGAT 2961 TAAATATGTGTGCAAAGTGTTTAGAAACCTATGAAATACTCTCGCAAAGATGCTGAGAGAGAATAAGAGGTTGGATTCCT 3041 CTTCATATAAACTAATTTTGGAGGAGGCCAGTTGGTTTGAAGTTACTTGAATGTTACCTTTTTTAGATGGGGCCAAATGG 3121 CATGTAGAATACACGTGATAGGTCAAAGCTGCTACACATTCTATACATGCATCAGCACAGCCCCCCCTTTCCAATCTGCA 3201 CTCCCATTCCAGCATAAACCTAGGAGAAATGTTTCGATTTCACACAAAGAAAGAGCACACGTCCACCATCTTCAGTGGGG 3281 GCTGTCTTTTGCTTCACTGGCAAGCAGGCACTGAATTTTTCTTGCATGACAAATCTGGAGGTTTACTGGTGAGAGAGCCA 3361 ATGGGCATTTTTTCCTGGAAAGAGTACAGCTCCATACCCAGTCCTAACCCAACAGTGATATTTATCACTTTGGGGCAGGG 3441 CTGTATAGAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGGGTTGGGGTGGTGTTGGGCC 3521 ATCTCTGGCCTGTTACTAAGGTAACTAGGACTATTTGTGTTCCAGCAGTCATAGCCTGTGATTGTGGGTGCATCAGTTCT 3601 CTGCCTAGATCTCTTGTTACCTTGTCTGCACATCAAGGGAGGGAGTTGAGCACAGATACTTGTCAAGGGCCATTGTAGTT 3681 GTGCAGTTCTCTAATGAAACACTCCCTAGTCCATGAGTTCACAAAATTTATTAAGATTAAATTATAAGTTGGATTTGTGA 3761 ATAATGACTAATTAATTGTCTTGCCCATTTTAGGTTAAGGTGAGAGCTTAGTCTCTTGCCCTTTGGGATTTGTCTTTTGG 3841 GGGATTAATGGAGACCAGATGTACTTGGGAGACTGGTGTCCAAATTCGGATCATGCCCTGTGTAGGCTCTCTCTATCCTC 3921 CCTTATAGCTCTTTAGTGTACTGTCACCGGGAGGGCTCATGCTGTGAGGGCATTTTTTGCATGGTGTTAAGACTAGTTAA 4001 AGAAATTTTAAGCTGTTGTTATTTGCAGTCAATTGTAGTACTTCATGTATCATGAATTCAAGTACTATGATCAGACAGAC 4081 ATCTCTCTCTCTCTCACACACACACACACACACACACACGCACACATACACACACACACACACACCTGAGGAAATGGCTG 4161 CTTTGGGTTCTATAAGGACCATTCCATGTTTAAAGTCCTAGTTGAGCTGAATGCTAAGAACCTGCCCCCTTGCCTCCCTC 4241 TGAGATGATATCATTTCCTGGCTTCGTCAATGCTGCCTGTCTATTTGCATGCTGGGTTCTGAGGACTAGTGAGAAGGTGA 4321 CCAGAGTTTGGGTGGGGCTGGTTTTTACCCACTGGATTTGGTGAGAATATGAAGCATCCAGTGTGTACCAGGGTTTCTGA 4401 ACCACGGGAAAGGCGTAGGAAAACAAACATTCAGAGCCCCTGTAAAACGAGAAAGGAAAAACCAGCCAGTGTTGCATTCC 4481 ACATCTCTGCTTGTTGCATTTTGCTAATATGGGGTTATTCTTTCTCACTGTTAGGATGCAATTGTGTGCAAAGACAGTGG 4561 CTGAGTGAACAGTAAGAGCTGGCTAGTAATGGCCTTAAAAAGAAAAAGGGTAACTCTCTGAAACAAAGATCACTTTAGTG 4641 TGGCATTGTGGATGCTGTTAATTCTGCATAGGGAAACTTTGGAACAGCATGCTAATTACATGGCTGTAAGCAAAGCCCTG 4721 TCCTCTGTCTCTGCACCATACCTTCATTGGACTTCACCAACCCATCCATACTCCATGTAAACCTCAGTTCTCTCATGCCT 4801 GCCCTAAGTCAGTTGACATCAGTGCAGTGGCATTGAGGAGAAATGAGAGGTGTCTCTGATTTTACTGAAAGTTATTATCA 4881 TTTTCACAGGTGCCTGAGATTTGGTATCTACTTTGTGTTCTTGATTCTTAGGTGAAAAATCTGAAATAGTTCCCTGTGCA 4961 TTAAAATAAATTATTTTGAGAGGACTCCTGCTCCGTCGATTCAGCAGACCTATGCTGCAGAAGGTAACTGCGGAAGCTCT 5041 CTTTTGCTGTCAGGGCTCTGAGCTTGAAGGGAGAAGGTGCAGTGGTGCCTAGAAGTGATATGCAAACCACCTCACATGCC 5121 AGCCTCTGGCCTCCTTCCCATCCCAGAGTCACAGACAGGGGACCCAGTGACAATGATGATAAATCCATGTGTGGAGGTGT 5201 TTTACTTATTTTTCTTTCCGTAGGATTTCATGGTGCTTTAAAAAAAAAGGCATTTTACAGAAAATAATGTGGGGGGAGGG 5281 AGATTTCATAATGTTCTTAGGGAAAGTACAAAACAAATTTGCTTGTGACATTTCAATAAGCTGTGCTGCTATTGTCTTTA 5361 TTTGATGATGTAATTTTTTTTTCAATGATGGAGAAAAATTGCAACAAAGACCTTCTGGAAGATCCAAAAAAAAAAAAAAA 5441 AAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
||||||||||||||||||||
miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
---|---|---|---|---|---|---|---|
miRNA:Target | ---- | ||||||
Validation Method |
|
||||||
Conditions | HEK293 | ||||||
Disease | 54207.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714646. RNA binding protein: AGO2. Condition:mildMNase
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
||||||
miRNA-target interactions (Provided by authors) |
|
||||||
Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
|
Experimental Support 2 for Functional miRNA-Target Interaction | |
---|---|
miRNA:Target | ---- |
Validation Method |
|
Conditions | Hela |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
|
Experimental Support 3 for Functional miRNA-Target Interaction | |
---|---|
miRNA:Target | ---- |
Validation Method |
|
Conditions | HEK293S |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1
HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1
HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2
HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2
HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3
HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3
HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4
HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4
HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb
HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb
HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb
HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb
HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb
HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb
HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb
HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb
HITS-CLIP data was present in GSM1084074. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SantaCruzAb
HITS-CLIP data was present in GSM1084075. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SantaCruzAb
HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb
HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb
HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb
HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb
HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb
HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb
HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb
HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb
... - Karginov FV; Hannon GJ, 2013, Genes & development. |
Article |
- Karginov FV; Hannon GJ - Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
|
Experimental Support 4 for Functional miRNA-Target Interaction | |
---|---|
miRNA:Target | ---- |
Validation Method |
|
Conditions | Cardiac Tissues |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA
... - Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research. |
Article |
Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP.
- Spengler RM; Zhang X; Cheng C; McLendon JM; et al.- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
|
Experimental Support 5 for Functional miRNA-Target Interaction | |
---|---|
miRNA:Target | ---- |
Validation Method |
|
Conditions | Liver Tissue |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM2550621. RNA binding protein: AGO2. Condition:Patient 2 Tumor 2
HITS-CLIP data was present in GSM2550618. RNA binding protein: AGO2. Condition:Patient 1 Tumor 1
... - Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al., 2017, Molecular cell. |
Article |
- Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al. - Molecular cell, 2017
MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. We observed a majority of miR-122 binding on 3' UTRs and coding exons followed by extensive binding to other genic and non-genic sites. Motif analysis of miR-122-dependent binding revealed a G-bulged motif in addition to canonical motifs. A large number of miR-122 targets were found to be species specific. Upregulation of several common mouse and human targets, most notably BCL9, predicted survival in HCC patients. These results broadly define the molecular consequences of miR-122 downregulation in hepatocellular carcinoma.
LinkOut: [PMID: 28735896]
|
CLIP-seq Support 1 for dataset GSM1048187 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000340700.5 | 3UTR | AGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGCGGGUUGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1048188 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_ptb_knockdown |
Location of target site | ENST00000340700.5 | 3UTR | GUAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGCG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM1084040 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noarsenite_rep1 |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM1084041 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_arsenite_rep1 |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM1084042 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noarsenite_rep2 |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 6 for dataset GSM1084043 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_arsenite_rep2 |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGCG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 7 for dataset GSM1084044 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noarsenite_rep3 |
Location of target site | ENST00000340700.5 | 3UTR | GUAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGCG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 8 for dataset GSM1084045 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_arsenite_rep3 |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 9 for dataset GSM1084046 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noarsenite_rep4 |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGCG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 10 for dataset GSM1084047 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_arsenite_rep4 |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 11 for dataset GSM1084064 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noemetine_AbnovaAb |
Location of target site | ENST00000340700.5 | 3UTR | GUAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 12 for dataset GSM1084065 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_AbnovaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 13 for dataset GSM1084066 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noemetine_SantaCruzAb |
Location of target site | ENST00000340700.5 | 3UTR | AUAGAGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 14 for dataset GSM1084067 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_SantaCruzAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 15 for dataset GSM1084068 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noemetine_SigmaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 16 for dataset GSM1084069 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_SigmaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 17 for dataset GSM1084072 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 18 for dataset GSM1084073 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep1_AbnovaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 19 for dataset GSM1084074 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep1_SantaCruzAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 20 for dataset GSM1084075 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep1_SantaCruzAb |
Location of target site | ENST00000340700.5 | 3UTR | UAGAGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 21 for dataset GSM1084076 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep1_SigmaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 22 for dataset GSM1084077 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep1_SigmaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 23 for dataset GSM1084078 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 24 for dataset GSM1084079 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep2_AbnovaAb |
Location of target site | ENST00000340700.5 | 3UTR | CUUUGGGGCAGGGCUGUAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 25 for dataset GSM1084081 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb |
Location of target site | ENST00000340700.5 | 3UTR | AUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 26 for dataset GSM1084082 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep2_SigmaAb |
Location of target site | ENST00000340700.5 | 3UTR | GUAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 27 for dataset GSM1084083 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep2_SigmaAb |
Location of target site | ENST00000340700.5 | 3UTR | UAUAGAGUGUGUGUGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 28 for dataset GSM714646 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / mildMNase, repA |
Location of target site | ENST00000340700.5 | 3UTR | AGAGUGUGUGUGUGUGUGUGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
---|---|---|---|---|---|---|---|
|
MiRNA-Target Expression Profile (TCGA) | |||||||
---|---|---|---|---|---|---|---|
|
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
![]() |
![]() |
|||||||
Strong evidence | Less strong evidence | |||||||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|||||
MIRT066415 | TBK1 | TANK binding kinase 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT073567 | NR2F2 | nuclear receptor subfamily 2 group F member 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT074516 | USP1 | ubiquitin specific peptidase 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT080576 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | ![]() |
![]() |
2 | 6 | ||||||
MIRT086539 | HSPE1-MOB4 | HSPE1-MOB4 readthrough | ![]() |
![]() |
2 | 2 | ||||||
MIRT086547 | MOB4 | MOB family member 4, phocein | ![]() |
![]() |
2 | 2 | ||||||
MIRT088684 | EML4 | echinoderm microtubule associated protein like 4 | ![]() |
![]() |
2 | 4 | ||||||
MIRT090811 | MBNL1 | muscleblind like splicing regulator 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT095500 | PURA | purine rich element binding protein A | ![]() |
![]() |
2 | 2 | ||||||
MIRT109530 | KLHL15 | kelch like family member 15 | ![]() |
![]() |
2 | 6 | ||||||
MIRT109807 | ZFX | zinc finger protein, X-linked | ![]() |
![]() |
2 | 2 | ||||||
MIRT117888 | ZBTB7A | zinc finger and BTB domain containing 7A | ![]() |
![]() |
2 | 2 | ||||||
MIRT120273 | GSK3B | glycogen synthase kinase 3 beta | ![]() |
![]() |
2 | 4 | ||||||
MIRT149892 | LDLR | low density lipoprotein receptor | ![]() |
![]() |
2 | 2 | ||||||
MIRT178475 | LCOR | ligand dependent nuclear receptor corepressor | ![]() |
![]() |
2 | 4 | ||||||
MIRT193445 | RORA | RAR related orphan receptor A | ![]() |
![]() |
2 | 2 | ||||||
MIRT198527 | DSG2 | desmoglein 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT226427 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT227669 | SET | SET nuclear proto-oncogene | ![]() |
![]() |
2 | 2 | ||||||
MIRT320405 | HOXA9 | homeobox A9 | ![]() |
![]() |
2 | 2 | ||||||
MIRT407774 | MRPL35 | mitochondrial ribosomal protein L35 | ![]() |
![]() |
2 | 2 | ||||||
MIRT439228 | ZMIZ1 | zinc finger MIZ-type containing 1 | ![]() |
1 | 1 | |||||||
MIRT439312 | VAT1L | vesicle amine transport 1 like | ![]() |
1 | 1 | |||||||
MIRT439421 | TMOD1 | tropomodulin 1 | ![]() |
1 | 1 | |||||||
MIRT439446 | TMEM104 | transmembrane protein 104 | ![]() |
1 | 1 | |||||||
MIRT439524 | STIM2 | stromal interaction molecule 2 | ![]() |
1 | 1 | |||||||
MIRT439612 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) | ![]() |
1 | 1 | |||||||
MIRT439997 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | ![]() |
1 | 1 | |||||||
MIRT440017 | PCSK1 | proprotein convertase subtilisin/kexin type 1 | ![]() |
1 | 1 | |||||||
MIRT440131 | NCOA4 | nuclear receptor coactivator 4 | ![]() |
1 | 1 | |||||||
MIRT440311 | LRRC1 | leucine rich repeat containing 1 | ![]() |
1 | 1 | |||||||
MIRT440475 | IAPP | islet amyloid polypeptide | ![]() |
1 | 1 | |||||||
MIRT440511 | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | ![]() |
1 | 1 | |||||||
MIRT440617 | FOXA2 | forkhead box A2 | ![]() |
1 | 1 | |||||||
MIRT440666 | FBXL16 | F-box and leucine rich repeat protein 16 | ![]() |
1 | 1 | |||||||
MIRT440705 | ERO1LB | endoplasmic reticulum oxidoreductase 1 beta | ![]() |
1 | 1 | |||||||
MIRT441007 | CAPZA2 | capping actin protein of muscle Z-line alpha subunit 2 | ![]() |
1 | 1 | |||||||
MIRT441018 | CAND1 | cullin associated and neddylation dissociated 1 | ![]() |
1 | 1 | |||||||
MIRT441062 | C1orf43 | chromosome 1 open reading frame 43 | ![]() |
1 | 1 | |||||||
MIRT441209 | ARCN1 | archain 1 | ![]() |
1 | 1 | |||||||
MIRT449461 | HAT1 | histone acetyltransferase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT467104 | SRI | sorcin | ![]() |
![]() |
2 | 2 | ||||||
MIRT468060 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | ![]() |
![]() |
2 | 10 | ||||||
MIRT468476 | SESN3 | sestrin 3 | ![]() |
![]() |
2 | 4 | ||||||
MIRT473533 | MAX | MYC associated factor X | ![]() |
![]() |
2 | 2 | ||||||
MIRT473852 | MAP2K4 | mitogen-activated protein kinase kinase 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT474711 | KIF13A | kinesin family member 13A | ![]() |
![]() |
2 | 6 | ||||||
MIRT481665 | ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT485120 | SF3B3 | splicing factor 3b subunit 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT493055 | MTFR1 | mitochondrial fission regulator 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT504258 | C1orf147 | chromosome 1 open reading frame 147 | ![]() |
![]() |
2 | 4 | ||||||
MIRT504361 | ARID1B | AT-rich interaction domain 1B | ![]() |
![]() |
2 | 4 | ||||||
MIRT505748 | SENP1 | SUMO1/sentrin specific peptidase 1 | ![]() |
![]() |
2 | 8 | ||||||
MIRT506298 | PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | ![]() |
![]() |
2 | 6 | ||||||
MIRT508442 | ZNF608 | zinc finger protein 608 | ![]() |
![]() |
2 | 4 | ||||||
MIRT512782 | COL4A3BP | collagen type IV alpha 3 binding protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT520447 | TSPAN2 | tetraspanin 2 | ![]() |
![]() |
2 | 4 | ||||||
MIRT522133 | NRBF2 | nuclear receptor binding factor 2 | ![]() |
![]() |
2 | 6 | ||||||
MIRT522395 | MYADM | myeloid associated differentiation marker | ![]() |
![]() |
2 | 4 | ||||||
MIRT523397 | GRIK3 | glutamate ionotropic receptor kainate type subunit 3 | ![]() |
![]() |
2 | 4 | ||||||
MIRT523938 | E2F8 | E2F transcription factor 8 | ![]() |
![]() |
2 | 4 | ||||||
MIRT524349 | CREB1 | cAMP responsive element binding protein 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT524711 | BRMS1L | breast cancer metastasis-suppressor 1 like | ![]() |
![]() |
2 | 4 | ||||||
MIRT525134 | ZNF256 | zinc finger protein 256 | ![]() |
![]() |
2 | 2 | ||||||
MIRT525710 | DCAF12L2 | DDB1 and CUL4 associated factor 12 like 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT531264 | PPIL3 | peptidylprolyl isomerase like 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT538844 | BTG1 | BTG anti-proliferation factor 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT541366 | CDKN1B | cyclin dependent kinase inhibitor 1B | ![]() |
![]() |
2 | 2 | ||||||
MIRT542093 | KCNK10 | potassium two pore domain channel subfamily K member 10 | ![]() |
![]() |
2 | 6 | ||||||
MIRT543770 | RBM12B | RNA binding motif protein 12B | ![]() |
![]() |
2 | 4 | ||||||
MIRT543940 | NCOA7 | nuclear receptor coactivator 7 | ![]() |
![]() |
2 | 2 | ||||||
MIRT545150 | GABRG1 | gamma-aminobutyric acid type A receptor gamma1 subunit | ![]() |
![]() |
2 | 2 | ||||||
MIRT545842 | ZNF264 | zinc finger protein 264 | ![]() |
![]() |
2 | 4 | ||||||
MIRT548057 | GOLGA7 | golgin A7 | ![]() |
![]() |
2 | 2 | ||||||
MIRT549242 | ATXN1L | ataxin 1 like | ![]() |
![]() |
2 | 4 | ||||||
MIRT551829 | AASDHPPT | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | ![]() |
![]() |
2 | 2 | ||||||
MIRT552484 | ZNF136 | zinc finger protein 136 | ![]() |
![]() |
2 | 2 | ||||||
MIRT553663 | TGFBR2 | transforming growth factor beta receptor 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT554988 | RAB39B | RAB39B, member RAS oncogene family | ![]() |
![]() |
2 | 2 | ||||||
MIRT555760 | PCTP | phosphatidylcholine transfer protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT556923 | IRF2BP2 | interferon regulatory factor 2 binding protein 2 | ![]() |
![]() |
2 | 4 | ||||||
MIRT564991 | WNK1 | WNK lysine deficient protein kinase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT566458 | PGGT1B | protein geranylgeranyltransferase type I subunit beta | ![]() |
![]() |
2 | 2 | ||||||
MIRT566538 | PANK3 | pantothenate kinase 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT567732 | DLX2 | distal-less homeobox 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT570081 | KANSL1L | KAT8 regulatory NSL complex subunit 1 like | ![]() |
![]() |
2 | 2 | ||||||
MIRT571735 | RNF11 | ring finger protein 11 | ![]() |
![]() |
2 | 2 | ||||||
MIRT573529 | MDM2 | MDM2 proto-oncogene | ![]() |
![]() |
2 | 2 | ||||||
MIRT574459 | RPS16 | ribosomal protein S16 | ![]() |
![]() |
2 | 2 | ||||||
MIRT574992 | Phka1 | phosphorylase kinase alpha 1 | ![]() |
![]() |
2 | 3 | ||||||
MIRT576349 | Pxdn | peroxidasin | ![]() |
![]() |
2 | 2 | ||||||
MIRT610196 | CD99 | CD99 molecule (Xg blood group) | ![]() |
![]() |
2 | 4 | ||||||
MIRT612920 | GPRIN3 | GPRIN family member 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT615021 | DUSP6 | dual specificity phosphatase 6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT623573 | IRS1 | insulin receptor substrate 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT624437 | CASD1 | CAS1 domain containing 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT628714 | ZNF585A | zinc finger protein 585A | ![]() |
![]() |
2 | 2 | ||||||
MIRT639565 | PCK1 | phosphoenolpyruvate carboxykinase 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT641485 | POLA2 | DNA polymerase alpha 2, accessory subunit | ![]() |
![]() |
2 | 2 | ||||||
MIRT641657 | PAPOLG | poly(A) polymerase gamma | ![]() |
![]() |
2 | 2 | ||||||
MIRT642210 | RUVBL2 | RuvB like AAA ATPase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT653010 | STX7 | syntaxin 7 | ![]() |
![]() |
2 | 2 | ||||||
MIRT656130 | MSH6 | mutS homolog 6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT656893 | KIAA2018 | upstream transcription factor family member 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT660130 | BRPF3 | bromodomain and PHD finger containing 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT660855 | AFAP1 | actin filament associated protein 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT676843 | PHKA1 | phosphorylase kinase regulatory subunit alpha 1 | ![]() |
![]() |
2 | 3 | ||||||
MIRT681473 | DIP2A | disco interacting protein 2 homolog A | ![]() |
![]() |
2 | 2 | ||||||
MIRT682253 | RS1 | retinoschisin 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT694296 | COPB2 | coatomer protein complex subunit beta 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT694401 | ALDH1A3 | aldehyde dehydrogenase 1 family member A3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT705277 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT720833 | C1orf52 | chromosome 1 open reading frame 52 | ![]() |
![]() |
2 | 2 | ||||||
MIRT735713 | SIRT1 | sirtuin 1 | ![]() |
![]() |
2 | 0 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|