miRTarBase - #MIRT543216


—
pre-miRNA Information
pre-miRNA hsa-mir-16-2   
Genomic Coordinates chr3: 160404745 - 160404825
Description Homo sapiens miR-16-2 stem-loop
Comment This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-16-2-3p
Sequence 53| CCAAUAUUACUGUGCUGCUUUA |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30477465 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs746992239 2 dbSNP
rs775368833 4 dbSNP
rs373202341 10 dbSNP
rs768780684 13 dbSNP
rs1341798864 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TMEM117   
Synonyms -
Description transmembrane protein 117
Transcript NM_032256   
Expression
Putative miRNA Targets on TMEM117
3'UTR of TMEM117
(miRNA target sites are highlighted)		 
>TMEM117|NM_032256|3'UTR
   1 ACTCGGAGATAGACTTGGAGATAACACAAAAAGCAACCTTGAGTGTAACTTTAAAAATTTAGTCTTTCCTTTTGTATATG
  81 TAAGGTTTACGTAGTGTTAGGTAAAAATATGAACAATGCCACAACGGTGCTCAACATGCTTTTTCTAGGATTCATTGTTT
 161 TCTATTTGTATTATAATACACGTGCCTACTGTATACTCAACAGTCCTCTAGAGATTGCTTTTCACAATTGCACAAGCTAT
 241 TACTGACTTTACAGCATAGTGGAAGATTAGCTGATGACCCATGTATCTGATGTTCAACCATAGTGGTGCCTTGAGACATT
 321 AAACTGTTTTTAACTGTACCAGAAATGAAGTGTGGAACAGTTACCTAACCTATTTCACATGGGCGTTTTGTATACAACTA
 401 TTTTGATCTACACTTGATGTCTGAGCAGAAAACAGAAATAGCTAAATGTGACTCAGGAAGTATCTCTTGGTTTCTTATTC
 481 AGCAGCAGAGTTGGTGACTTTGACAACTGGACTGCAGAGAAACATGGTGATCACCTTTTAATTTTTATTGGCTGTCTGCC
 561 AAATATAAATACAGATGCAAAATTCAGTAATAGGAGATCCATAACCCAACATGGGTCACTACTCGTGAAATGTGACTTTC
 641 TCCCACCAGTAATTGAAATGAGGTGATGATACCTAATTATGTTTTCCTAATTAAAGATAAATTGCTACTTGATTAAAAAT
 721 CCTGCCCTTCACCTTTGGGAACAAAGGTTAAGAGACACAGTTGGGCGAACTCTCAAATTTATTGGCATTTACACAAAGTC
 801 CCAGACAACCAAGGAACTGAAGTTTTCATCATATGAGAGCAGCACATCCCACCATTTACAATATTCGTATATCTTTCTGC
 881 AAATATGGCTCTGGATAGTGAAAATTGAAAAACATATGCCAACCCTGAGCAAGGGAACTCCTCAAAAAATCATGCAGCGG
 961 AACCTTGTCAGGTAGAGAAGCCGTGCATGAAAGAATTTGTTTAATGTCTTGTTTTGCGTATGTGTTTTTTGTTTTTGTTT
1041 TTTAAGAACTAAATATTGCACATTAATAAATAAGAATTATACAGCAGTGAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auUUCGUCGUGU---------CA--UUAUAAcc 5'
            :|||||||||          |  ||||||  
Target 5' gaGAGCAGCACATCCCACCATTTACAATATTcg 3'
 835 - 867 134.00 -14.66
2 
miRNA  3' auuucGUCGUGUCA-UUAUAACc 5'
               | | |:||| || |||| 
Target 5' tggctCTGGATAGTGAAAATTGa 3'
 886 - 908 125.00 -7.90
3 
miRNA  3' auuucGUCGUGUCA--UUAUAAcc 5'
               |||||:|||  || |||  
Target 5' ctttaCAGCATAGTGGAAGATTag 3'
 247 - 270 119.00 -14.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30168616 8 COSMIC
COSN30517463 13 COSMIC
COSN30464509 47 COSMIC
COSN20077673 48 COSMIC
COSN31585555 56 COSMIC
COSN31589731 91 COSMIC
COSN31561631 136 COSMIC
COSN1148292 183 COSMIC
COSN31513609 200 COSMIC
COSN15153755 206 COSMIC
COSN26668940 210 COSMIC
COSN21751599 233 COSMIC
COSN30173666 348 COSMIC
COSN29482089 380 COSMIC
COSN29480926 396 COSMIC
COSN31541872 405 COSMIC
COSN31591479 498 COSMIC
COSN31542830 542 COSMIC
COSN22861658 547 COSMIC
COSN30541349 572 COSMIC
COSN1574053 612 COSMIC
COSN18910505 667 COSMIC
COSN23013645 669 COSMIC
COSN31563342 702 COSMIC
COSN26568909 768 COSMIC
COSN31596362 786 COSMIC
COSN29504938 899 COSMIC
COSN31553668 914 COSMIC
COSN26601969 977 COSMIC
COSN7371525 984 COSMIC
COSN24108272 1019 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs149976837 5 dbSNP
rs371152093 6 dbSNP
rs1489353773 13 dbSNP
rs373407912 14 dbSNP
rs578066853 15 dbSNP
rs765369238 16 dbSNP
rs1169671823 18 dbSNP
rs775711178 21 dbSNP
rs763278415 26 dbSNP
rs376347780 27 dbSNP
rs748707212 28 dbSNP
rs1159054450 31 dbSNP
rs201223144 34 dbSNP
rs1463354660 35 dbSNP
rs1326917461 42 dbSNP
rs370747718 43 dbSNP
rs1394201007 46 dbSNP
rs185536396 53 dbSNP
rs1246742549 55 dbSNP
rs900116837 65 dbSNP
rs1162152841 78 dbSNP
rs1416800586 83 dbSNP
rs1405559814 85 dbSNP
rs914660803 86 dbSNP
rs996168692 91 dbSNP
rs755027648 92 dbSNP
rs565260155 96 dbSNP
rs75751564 120 dbSNP
rs1294159079 123 dbSNP
rs1443265684 124 dbSNP
rs781288605 125 dbSNP
rs938526469 126 dbSNP
rs959683587 127 dbSNP
rs573957006 137 dbSNP
rs1230375528 155 dbSNP
rs991156957 165 dbSNP
rs1425489761 178 dbSNP
rs1048142258 181 dbSNP
rs907762542 182 dbSNP
rs541726969 183 dbSNP
rs1292232676 185 dbSNP
rs1435900283 196 dbSNP
rs1481259648 197 dbSNP
rs1253408607 201 dbSNP
rs1203474431 202 dbSNP
rs968632739 211 dbSNP
rs1304523480 227 dbSNP
rs1236771006 228 dbSNP
rs774616106 231 dbSNP
rs979089707 240 dbSNP
rs368838752 252 dbSNP
rs559462196 262 dbSNP
rs1330788044 268 dbSNP
rs190380999 278 dbSNP
rs878916564 283 dbSNP
rs145250942 284 dbSNP
rs1300839594 289 dbSNP
rs1185210012 317 dbSNP
rs900271801 330 dbSNP
rs974612893 331 dbSNP
rs934494807 333 dbSNP
rs1359375694 336 dbSNP
rs931751076 341 dbSNP
rs1051501550 342 dbSNP
rs912689732 346 dbSNP
rs1379102979 347 dbSNP
rs1178750661 356 dbSNP
rs1164664372 363 dbSNP
rs372801938 378 dbSNP
rs1408583852 379 dbSNP
rs752533688 380 dbSNP
rs563766113 385 dbSNP
rs1371791814 386 dbSNP
rs944011556 390 dbSNP
rs1311192976 391 dbSNP
rs1339970170 392 dbSNP
rs181794381 393 dbSNP
rs1351818859 395 dbSNP
rs1448801742 395 dbSNP
rs1286182433 398 dbSNP
rs1337679747 400 dbSNP
rs1227476903 401 dbSNP
rs1308582780 411 dbSNP
rs1039674320 418 dbSNP
rs1337449833 423 dbSNP
rs899834263 428 dbSNP
rs1355791266 440 dbSNP
rs771929699 443 dbSNP
rs549150148 453 dbSNP
rs1314517541 454 dbSNP
rs1417438742 460 dbSNP
rs1031932481 463 dbSNP
rs1158618956 464 dbSNP
rs1454950314 467 dbSNP
rs1366057995 494 dbSNP
rs879088596 499 dbSNP
rs569120750 515 dbSNP
rs186863749 520 dbSNP
rs755868832 523 dbSNP
rs1258604963 524 dbSNP
rs775435626 525 dbSNP
rs866541652 527 dbSNP
rs1487417452 535 dbSNP
rs1285646814 538 dbSNP
rs1461061151 539 dbSNP
rs546893777 540 dbSNP
rs1352844504 541 dbSNP
rs539983666 545 dbSNP
rs571478600 551 dbSNP
rs1188949135 573 dbSNP
rs1243913156 574 dbSNP
rs760387424 575 dbSNP
rs538612831 587 dbSNP
rs1294870440 590 dbSNP
rs1011599180 596 dbSNP
rs149154565 602 dbSNP
rs970066516 603 dbSNP
rs568565831 605 dbSNP
rs980633489 614 dbSNP
rs895605609 615 dbSNP
rs1318643976 622 dbSNP
rs1383568606 626 dbSNP
rs1391151955 635 dbSNP
rs535952374 636 dbSNP
rs1461348407 649 dbSNP
rs1419269055 656 dbSNP
rs1167528990 663 dbSNP
rs7974460 669 dbSNP
rs1262924717 672 dbSNP
rs968808623 673 dbSNP
rs978672848 687 dbSNP
rs1415123910 689 dbSNP
rs1336239792 697 dbSNP
rs1324945186 705 dbSNP
rs113198055 708 dbSNP
rs960151855 710 dbSNP
rs1434618859 720 dbSNP
rs1275039088 724 dbSNP
rs1298546005 728 dbSNP
rs1216566764 748 dbSNP
rs574200330 759 dbSNP
rs1367129892 762 dbSNP
rs983208861 767 dbSNP
rs907814666 768 dbSNP
rs190128717 777 dbSNP
rs941922768 786 dbSNP
rs534937168 788 dbSNP
rs1441077229 791 dbSNP
rs553617155 792 dbSNP
rs1201745451 795 dbSNP
rs973278949 797 dbSNP
rs911735841 805 dbSNP
rs1168886735 808 dbSNP
rs1476497293 813 dbSNP
rs1376186511 822 dbSNP
rs1193074513 824 dbSNP
rs1208990511 831 dbSNP
rs1249461040 833 dbSNP
rs1254972614 837 dbSNP
rs1451726875 840 dbSNP
rs1196620591 850 dbSNP
rs1457282152 859 dbSNP
rs143364626 860 dbSNP
rs931662181 861 dbSNP
rs112730051 865 dbSNP
rs545419121 868 dbSNP
rs1478624437 870 dbSNP
rs1051960474 872 dbSNP
rs1234575140 874 dbSNP
rs563674200 876 dbSNP
rs1445163183 881 dbSNP
rs931333767 886 dbSNP
rs1329940044 891 dbSNP
rs575764741 906 dbSNP
rs887401537 914 dbSNP
rs1053251555 915 dbSNP
rs1321471254 924 dbSNP
rs1454883423 939 dbSNP
rs1057197195 954 dbSNP
rs1176893661 956 dbSNP
rs147923815 959 dbSNP
rs753757215 960 dbSNP
rs761501782 964 dbSNP
rs558899564 968 dbSNP
rs1300330999 978 dbSNP
rs905893290 983 dbSNP
rs181056241 984 dbSNP
rs1235302145 1002 dbSNP
rs1044551019 1007 dbSNP
rs1277654234 1015 dbSNP
rs752003104 1017 dbSNP
rs780149326 1019 dbSNP
rs528267535 1026 dbSNP
rs1466850581 1032 dbSNP
rs546510073 1038 dbSNP
rs879422179 1046 dbSNP
rs747139984 1061 dbSNP
rs1312681578 1065 dbSNP
rs1008822096 1073 dbSNP
rs963160858 1081 dbSNP
rs1400260663 1083 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 84216.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000551577.1 | 3UTR | AACUAAAUAUUGCACAUUAAUAAAUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.824 2.7e-4 0.747 1.7e-3 13 Click to see details
GSE19783 ER- ER- breast cancer -0.32 2.0e-3 -0.307 3.0e-3 79 Click to see details
GSE19536 Breast cancer -0.26 4.5e-3 -0.211 1.8e-2 100 Click to see details
GSE28544 Breast cancer -0.419 2.1e-2 -0.536 3.5e-3 24 Click to see details
GSE32688 Pancreatic cancer 0.339 2.9e-2 0.339 2.9e-2 32 Click to see details
GSE21687 Ependynoma primary tumors -0.224 3.8e-2 0.002 4.9e-1 64 Click to see details
GSE38226 Liver fibrosis -0.245 1.4e-1 -0.128 2.9e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.246 1.5e-1 0.418 3.3e-2 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.199 1.8e-1 0.048 4.1e-1 24 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.32 2.0e-1 -0.550 6.2e-2 9 Click to see details
GSE42095 Differentiated embryonic stem cells -0.152 2.4e-1 -0.268 1.1e-1 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.124 2.8e-1 0.110 3.0e-1 25 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.111 3.0e-1 0.219 1.5e-1 25 Click to see details
GSE19783 ER+ ER+ breast cancer 0.054 4.1e-1 0.304 9.6e-2 20 Click to see details
GSE19350 CNS germ cell tumors -0.066 4.2e-1 -0.084 4.0e-1 12 Click to see details
GSE21032 Prostate cancer -0.007 4.7e-1 0.021 4.3e-1 83 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.328 0.09 -0.186 0.22 19 Click to see details
THCA -0.179 0.09 -0.072 0.29 59 Click to see details
KIRP 0.239 0.09 0.148 0.21 32 Click to see details
PAAD -0.812 0.09 -0.800 0.1 4 Click to see details
STAD -0.237 0.1 -0.246 0.09 31 Click to see details
KIRC 0.119 0.17 0.151 0.11 68 Click to see details
LUSC 0.159 0.17 0.043 0.4 38 Click to see details
CESC 0.836 0.18 0.500 0.33 3 Click to see details
PCPG -0.832 0.19 -0.500 0.33 3 Click to see details
BRCA -0.097 0.19 -0.162 0.07 83 Click to see details
LIHC 0.112 0.22 0.187 0.1 49 Click to see details
HNSC -0.107 0.25 -0.060 0.35 42 Click to see details
PRAD 0.084 0.29 0.064 0.33 48 Click to see details
LUAD -0.113 0.36 -0.259 0.21 12 Click to see details
ESCA -0.116 0.37 -0.218 0.26 11 Click to see details
KICH 0.057 0.39 0.051 0.4 25 Click to see details
CHOL -0.086 0.41 0.100 0.4 9 Click to see details
BLCA 0.009 0.49 -0.049 0.42 18 Click to see details
BLCA 0.009 0.49 -0.049 0.42 18 Click to see details
BLCA 0.009 0.49 -0.049 0.42 18 Click to see details
75 hsa-miR-16-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004488 RARB retinoic acid receptor beta 3 1
MIRT038707 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 1 1
MIRT057208 PPIF peptidylprolyl isomerase F 2 4
MIRT058726 RSBN1 round spermatid basic protein 1 2 8
MIRT074502 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 4
MIRT081544 ZNF431 zinc finger protein 431 2 4
MIRT096893 ERBB2IP erbb2 interacting protein 2 2
MIRT105124 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT107898 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT109432 KLHL15 kelch like family member 15 2 6
MIRT166742 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 6
MIRT171257 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 2 2
MIRT192760 B2M beta-2-microglobulin 2 2
MIRT194905 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT215599 SUB1 SUB1 homolog, transcriptional regulator 2 2
MIRT223632 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT241605 AMOTL1 angiomotin like 1 2 4
MIRT291174 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT444286 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT463285 ZFX zinc finger protein, X-linked 2 4
MIRT471759 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT479611 CDC25A cell division cycle 25A 2 2
MIRT481497 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 8
MIRT483117 SH3BP5 SH3 domain binding protein 5 2 2
MIRT502279 GRPEL2 GrpE like 2, mitochondrial 2 8
MIRT507838 CCNT1 cyclin T1 2 2
MIRT508179 MTRNR2L6 MT-RNR2-like 6 2 4
MIRT510576 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 6
MIRT517853 RPS4X ribosomal protein S4, X-linked 2 4
MIRT521690 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT525070 FRK fyn related Src family tyrosine kinase 2 2
MIRT527082 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT529552 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530426 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT533909 TBC1D15 TBC1 domain family member 15 2 2
MIRT536627 IPO7 importin 7 2 2
MIRT537647 ERGIC2 ERGIC and golgi 2 2 4
MIRT538512 CLCN3 chloride voltage-gated channel 3 2 2
MIRT539219 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT539348 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT539954 CCT4 chaperonin containing TCP1 subunit 4 2 2
MIRT541208 HOXA10 homeobox A10 2 2
MIRT543216 TMEM117 transmembrane protein 117 2 2
MIRT543399 DROSHA drosha ribonuclease III 2 2
MIRT546648 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT546852 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT549917 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT552998 USP46 ubiquitin specific peptidase 46 2 2
MIRT555254 PREPL prolyl endopeptidase-like 2 2
MIRT555956 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT557095 HOXA9 homeobox A9 2 2
MIRT561396 TUBB2A tubulin beta 2A class IIa 2 2
MIRT561654 RNF219 ring finger protein 219 2 2
MIRT563101 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT565979 RNF44 ring finger protein 44 2 2
MIRT572396 CCDC14 coiled-coil domain containing 14 2 2
MIRT574400 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT607623 VSNL1 visinin like 1 2 2
MIRT610645 CTGF connective tissue growth factor 2 2
MIRT623379 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT624687 AR androgen receptor 2 2
MIRT632089 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT644216 CBS cystathionine-beta-synthase 2 2
MIRT647841 BID BH3 interacting domain death agonist 2 2
MIRT651649 WASF2 WAS protein family member 2 2 2
MIRT689064 AGMAT agmatinase 2 2
MIRT698150 TNPO1 transportin 1 2 2
MIRT700516 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT704081 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT705970 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT715694 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT717184 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT724607 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT724854 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT725401 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-16-2 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-16-2-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-16-2-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-16-2-3p Bortezomib 387447 NSC681239 approved resistant Low Multiple Myeloma tissue
hsa-miR-16-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-16-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-16-2-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-16-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (HCT8)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission