miRTarBase - #MIRT544301


—
pre-miRNA Information
pre-miRNA hsa-mir-4259   
Genomic Coordinates chr1: 159899979 - 159900079
Description Homo sapiens miR-4259 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4259
Sequence 70| CAGUUGGGUCUAGGGGUCAGGA |91
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1237551241 4 dbSNP
rs772339482 8 dbSNP
rs1314022637 15 dbSNP
rs1414601728 19 dbSNP
rs746067692 20 dbSNP
rs779101228 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TSPYL1   
Synonyms TSPYL
Description TSPY like 1
Transcript NM_003309   
Expression
Putative miRNA Targets on TSPYL1
3'UTR of TSPYL1
(miRNA target sites are highlighted)		 
>TSPYL1|NM_003309|3'UTR
   1 CATTTGCCCTTGGGAATACTCCTGCACAAGGTCTCCTACCACCTTCTGCTGGACCTGTGCTTGGGCATCAGCAATGAGTA
  81 TGCCTTCTATTGTGCTTTGTTTTTGCTGACTTTTCTGCACCCTGTTTCCTTTGGATATTCAGTTCTCTCAACCTCAAGAT
 161 TGAGACGGTGGTGGGTATGCTTCTCCACTTCCATATGACCTTCATGCTGTTCTGGAATATCACATGCTACGAGGTCATCC
 241 TTCACACTACTTGTAAGCCAAGCAAATGATACTGTAGATTGTACTGCCTTTATCTGCACTGCTTGGACCCTGTTTATTCC
 321 CAGGGCCTCTGAACTGGTTGCTGTCACTTGGATTTCTAGCTTTGGGAGCCTGTTCCACCTACTCAGCTCTGCATTGAGCA
 401 GTATGGGCACATGCCCTGTGGACAGTTACTGGACGTTAATGAACTCAGAGGAGAAAAGCAGTGAGCCACTTGTTCTGTGT
 481 GATTTATGGTACTTCATTGCTCTTCCTTCACCTCTAGTCACTTTCTATTGCTACCTGCCCTACATTGGCTCCTGCCAAGG
 561 TCCCTCTCTCTCCCTGTTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGGACGGAGTCTTGCTCTGTCGCCC
 641 AGGTTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTC
 721 CCGAGTAGCTGGGACTACAGGCGCGCGCCGCCACGCCCGGCTAATTTTTATATTTTTAGTAGAGACGGGGTTTCACCATG
 801 CTGGCCAGGCTGGTCTCGAACCCCGATCTCGTGATCCGCCCTCCTTAGCCTCCCAATCCTCTCTTAAAAAAGTGATAGCT
 881 CAGAAACATTTGTAAAAGCAAGGTTTTTATTTCATTTTGGCTCTGTCATTTTCAGAGGCAAAGAAGTTGGCCTGTAAAAT
 961 AGAGTGCTAGAGCTCTTACGCCCCTCCCCTTCTTCCCAACTTCCTACTTCCTAGCCCTTTTATCAACTCCTAGAATAGTT
1041 AAAGAGAGACACATCTAGATGGGATGAAAGGTGCCCTAAGCAGGAGAAACTGAACAAAAGGCTAGAGGCATGGGCCAGGT
1121 AAAAATTGGGCCTAGAGTGAAGACTGTGCTGTCGTTAAGAGCTTTCGAGGAAGGAGTACTTACTCCCCAATGATGATGAA
1201 TGGAAAAATACTTTTCAGGGAGAATTGAAGGGGTTAAAGTGTTAAATATGTTGCCTAGACAAGGGTTCTTTAAAGAAAGA
1281 CAGCGCAACTTTGAATGCTTTCTTACTTGTTTTGTGACCTAATTTATGTGGAAGATTGTTATTTCATTAGGATTTAGTAA
1361 AATTTTTTTTTCTGATTCTAAACTTATTGTGAAAATTGAGCTGTACAGATATTCTTTTGATTTCAATTGGGAACATTTGG
1441 AAGAACAACAGTCTTACTTGCCTGTACAATATAGAGACATATGAATAGTCATAACAGTTTTCAACTTGTTCTTGTTTCTG
1521 TTAAACTATATTCCTAGAAACATAGTTTGAACAACTTGGTCTTTGTTAGGCTTGTCAAATTGCCTTCATGGAAAAATAAT
1601 CTACAAAAGTATGGTTTAATTGATTGTCTTACATGATAATTTTCCCTGGTAACAACTTAGTAAGTGATATATCTTTTTTC
1681 CTAAATTGCTTAAATACTGTGAAATTGCTCTGACAAATTGGAAGTGTACCATTGGCATATTTGTCTTCCTTTTTATGCAT
1761 GATGGTAAAATAAAAGCATGTTGTTCTGCTAGATTTCTTATTTTTCACCTTACCCATAAATGTAATGCTTGAATGAAGTT
1841 GTTCATATTAATTAAAAATTATGGAATCATTAAAGTCCTTTAATCCATTAAAGTTCTTAATGGATTAAAATCATTAAAGT
1921 TCTTAATGGATTAAAATCATTAAAGTCCTTAAATTGATGTTAACTAAAAATTACAGAATCATTAAAGTCCTTAAATGGAC
2001 ACAATAGACATTATCCCAAAGAGAAGAAAGCAGGGCACGGTATGTTTGGTACCTTCCAAGGTAGTTTGCCTTAAAACGTT
2081 AGCAGTTGCAACTGCTTACTCAATCACTTTTTTCCATGTAGTTTATGCAGCACAACCTCCCCTTCAGTTGCTCAAATCCT
2161 CCATTTCTGTCTCCATAAATTATATTCTCAGGTTATTCAGGCTCTTCTTTTTATTAACTTGTATGCAGGGAGTACCTATC
2241 ATATGTGATGTACTCCTCTATTTTCATACTTTCTCATCTGTAAAAACTTCCTTTTTTTCTTTAAACTTCCTCACTGTTCT
2321 CTTCTGTCAAATCCTTCAAGGCCTGCCCTTGGTAATTCCTCTGCCAAAGTCTTTCTGTTCCCCATAGAGGAGATAAATGT
2401 TTCTTTATGCACTTAGTGTACTTTGGAGGGACCTCTGTTCTAGAAAATTAACATAATTATTCATTACAGTGAATTCCACA
2481 AATAGAGAAAAAGAGTAAGAAGATAAAGTCCATTCCCTTCTTTGGGGAACTGGGGAAGGACTGATAAGCAAACAAAGAAT
2561 TAACAGAGTGATACAGTAAAATAAAATACAGAGATTATATTTTCATGTTTTTCCCATGTTCACTCTTTTCCTCTCAGTAG
2641 TTTGGAAACTTTGTGAAAGTGGAGATGCAGTGCATTTTACATGGTTCATTGCATCTAGCATTTTTTTTTTTTTTTTTTGA
2721 GATAGAGTCCCACTCTTGCCCAGGCTGGAGCGCAAGTGGCGCGATCTCGGCTCACTGCAACTTCCGCCTCCCGGTTTCAA
2801 GCAGTTCTCCAGCATCAGCCTCCCGAGTAGCTGGGACTACAGGCACGTGCTACCACGCCCGGCTAATTTTTTGTATTTTT
2881 AGTAGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCCATCTCCTGACCTCGTGATCAGCCCACCTCAGCCTCCCAA
2961 AGTGCTGGGATTACAGGCGTGAGCCACCGCACCCAGCCCATCTAGCATAATGTTTTGCATAGTTGTCAGCAGATAAATAT
3041 TGAATGACAAAACTCAGATGGAGGAAAAAGAACAAAATAACCTAGTTCTCAGAAAGATTTAATGAGCAAATGGGAAAATG
3121 TCAAAAAGATTTGCAATGCCATTCCTAAATAACTATTTCCCCTTTTAGTCATTAGAAAACGTCTAAACACTTTCAACATT
3201 AAATCTTTCACTTGCATTTTAACAGAGCACTACTTAATTTTGGGTTACCTTTTATATACTTTGTACATTTTAAGGTGATT
3281 ATACTGGAGATAGAAGGGGGTTAGACTCTAGATGTGTGTTGTCCAATACAGTAACTTTTAGCCACCAGTGGCTATTGAGC
3361 ACTTGAAATGTGGCTAGTCTGAATTGAGATCTATAAATATAAAATTCACACTGGATTTTGAAGACTCAGTATGGAAAGAA
3441 AAATGTTAAAATATCTCAATTTTTTTCATATTGATTGCATGTTGAAATATTTTTGACATTGTGTTAAAATATATTGAAAA
3521 ATTAATTATCCTCATTTTGCCATTGTTTAATGTGGCTACTAGTAAATCTAAAATTACATAGGACAGCATGTCTCGACTTC
3601 CTGAGGAATATCTGAAAGCATATAAAATATCTGTAAAAATTAAACATGTTAATACTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aggacuGGGGAUCUGGGUUGAc 5'
                |||:|   ||||||| 
Target 5' cccctcCCCTTCTTCCCAACTt 3'
 981 - 1002 152.00 -21.70
2 
miRNA  3' agGACUGGGGAUCU----GGGUUGAc 5'
            ||||||:|  ||    |||| || 
Target 5' tcCTGACCTCGTGATCAGCCCACCTc 3'
 2925 - 2950 134.00 -21.80
3 
miRNA  3' agGACUGG--GGAUCUGGGUUGAc 5'
            ||| :|  |||  ||:||:|| 
Target 5' gcCTGTTCCACCT--ACTCAGCTc 3'
 368 - 389 126.00 -20.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26633598 15 COSMIC
COSN31613253 74 COSMIC
COSN30457475 80 COSMIC
COSN7782296 207 COSMIC
COSN24477582 527 COSMIC
COSN22286132 787 COSMIC
COSN6722336 828 COSMIC
COSN30165074 1052 COSMIC
COSN14868023 1205 COSMIC
COSN31611154 1297 COSMIC
COSN22472287 1309 COSMIC
COSN24143285 1363 COSMIC
COSN31572283 1372 COSMIC
COSN4919243 1472 COSMIC
COSN21311244 1618 COSMIC
COSN22822874 1872 COSMIC
COSN14763379 1956 COSMIC
COSN2135794 2495 COSMIC
COSN19313436 2704 COSMIC
COSN20687931 2816 COSMIC
COSN14759423 3137 COSMIC
COSN14787647 3433 COSMIC
COSN2135793 3451 COSMIC
COSN22881831 3459 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs73767711 1 dbSNP
rs1368279546 2 dbSNP
rs888470546 9 dbSNP
rs771702078 12 dbSNP
rs9400897 15 dbSNP
rs112613011 21 dbSNP
rs193166930 22 dbSNP
rs756688667 30 dbSNP
rs1269550177 32 dbSNP
rs748652875 33 dbSNP
rs781310188 36 dbSNP
rs1274172473 37 dbSNP
rs369990802 38 dbSNP
rs1245345488 51 dbSNP
rs1031328460 52 dbSNP
rs1177595874 59 dbSNP
rs1002487042 60 dbSNP
rs532902666 61 dbSNP
rs762365421 62 dbSNP
rs988712642 78 dbSNP
rs1173273643 83 dbSNP
rs1358077900 84 dbSNP
rs1022676196 89 dbSNP
rs1466484006 90 dbSNP
rs1338684000 91 dbSNP
rs1397820738 92 dbSNP
rs1445821592 99 dbSNP
rs1274366334 107 dbSNP
rs1331822379 110 dbSNP
rs563072302 113 dbSNP
rs1218506680 115 dbSNP
rs1316477798 119 dbSNP
rs3180061 123 dbSNP
rs557758312 124 dbSNP
rs1383039288 134 dbSNP
rs1013512558 142 dbSNP
rs898637668 146 dbSNP
rs544799930 147 dbSNP
rs1038923184 149 dbSNP
rs940282758 151 dbSNP
rs1456848992 152 dbSNP
rs1198353375 153 dbSNP
rs1233833365 155 dbSNP
rs1189163323 158 dbSNP
rs887347643 166 dbSNP
rs953933508 182 dbSNP
rs1051134103 188 dbSNP
rs574319533 196 dbSNP
rs1438710123 197 dbSNP
rs921357188 199 dbSNP
rs998775950 200 dbSNP
rs965515679 204 dbSNP
rs562360062 205 dbSNP
rs1330621707 209 dbSNP
rs1292056087 212 dbSNP
rs1463967300 213 dbSNP
rs1425562463 235 dbSNP
rs1170862391 236 dbSNP
rs1432301312 249 dbSNP
rs975493803 251 dbSNP
rs1316533682 256 dbSNP
rs1218570634 261 dbSNP
rs1015749839 263 dbSNP
rs1309689690 270 dbSNP
rs943216084 272 dbSNP
rs888690960 277 dbSNP
rs914435941 287 dbSNP
rs990377900 288 dbSNP
rs955991682 292 dbSNP
rs1260424079 294 dbSNP
rs1168485426 295 dbSNP
rs1002170539 298 dbSNP
rs905282050 301 dbSNP
rs753358871 303 dbSNP
rs765873484 306 dbSNP
rs1046446988 309 dbSNP
rs145310103 315 dbSNP
rs971005369 332 dbSNP
rs188193873 336 dbSNP
rs1012689365 343 dbSNP
rs898223882 356 dbSNP
rs934618740 363 dbSNP
rs1226923977 366 dbSNP
rs557882952 370 dbSNP
rs1359632541 375 dbSNP
rs1224253819 376 dbSNP
rs539893688 378 dbSNP
rs1487705636 379 dbSNP
rs925854655 382 dbSNP
rs1449525364 391 dbSNP
rs978844120 401 dbSNP
rs1471784927 405 dbSNP
rs1017135429 408 dbSNP
rs953711138 411 dbSNP
rs1425531663 415 dbSNP
rs1165772024 416 dbSNP
rs3180062 426 dbSNP
rs1358675973 428 dbSNP
rs1419217090 434 dbSNP
rs575626967 435 dbSNP
rs763653804 451 dbSNP
rs965109193 481 dbSNP
rs557460795 502 dbSNP
rs887358994 503 dbSNP
rs1051313585 511 dbSNP
rs1352573615 512 dbSNP
rs1311909190 514 dbSNP
rs1299481322 517 dbSNP
rs933992753 522 dbSNP
rs899808511 527 dbSNP
rs1308589259 534 dbSNP
rs1209417340 538 dbSNP
rs1444539067 540 dbSNP
rs1446271334 545 dbSNP
rs537638071 549 dbSNP
rs1185620419 550 dbSNP
rs1402362629 551 dbSNP
rs567167163 556 dbSNP
rs1298608699 563 dbSNP
rs1040086907 564 dbSNP
rs200540393 565 dbSNP
rs1413259576 571 dbSNP
rs1336713233 572 dbSNP
rs1407263435 573 dbSNP
rs1454883514 573 dbSNP
rs1002628118 574 dbSNP
rs1177830387 575 dbSNP
rs770133279 576 dbSNP
rs1454422995 581 dbSNP
rs1280782713 582 dbSNP
rs1383085735 582 dbSNP
rs1263719567 583 dbSNP
rs1462620635 583 dbSNP
rs1196472634 584 dbSNP
rs946834233 585 dbSNP
rs1237354671 588 dbSNP
rs1176217803 589 dbSNP
rs1046816111 593 dbSNP
rs1182881000 599 dbSNP
rs1438461817 604 dbSNP
rs915277003 607 dbSNP
rs13193423 608 dbSNP
rs1013658054 609 dbSNP
rs1168897306 609 dbSNP
rs1175838273 609 dbSNP
rs1196579591 609 dbSNP
rs1216723571 609 dbSNP
rs1252881144 609 dbSNP
rs1257182376 609 dbSNP
rs1283392475 609 dbSNP
rs1328813937 609 dbSNP
rs1330533761 609 dbSNP
rs1339898063 609 dbSNP
rs1391599914 609 dbSNP
rs1396312740 609 dbSNP
rs1403751511 609 dbSNP
rs1430553625 609 dbSNP
rs1434543083 609 dbSNP
rs1450108666 609 dbSNP
rs1450265929 609 dbSNP
rs1477106056 609 dbSNP
rs1491139832 609 dbSNP
rs57691187 609 dbSNP
rs1303157169 610 dbSNP
rs1423616042 610 dbSNP
rs1491392763 610 dbSNP
rs1398053104 611 dbSNP
rs1196829806 612 dbSNP
rs548815159 613 dbSNP
rs1326988979 614 dbSNP
rs533846822 621 dbSNP
rs1263471618 623 dbSNP
rs1222120399 625 dbSNP
rs1354427968 625 dbSNP
rs1213344329 628 dbSNP
rs1292577850 630 dbSNP
rs1490876075 632 dbSNP
rs1054218692 633 dbSNP
rs1261591265 634 dbSNP
rs746406277 634 dbSNP
rs1238059587 636 dbSNP
rs566432504 637 dbSNP
rs1443627790 641 dbSNP
rs1163893079 646 dbSNP
rs1307641066 649 dbSNP
rs1417363312 667 dbSNP
rs1287806886 671 dbSNP
rs1385509363 673 dbSNP
rs1383856607 675 dbSNP
rs1310306625 678 dbSNP
rs373571069 680 dbSNP
rs1245495548 681 dbSNP
rs924563333 685 dbSNP
rs1361906316 690 dbSNP
rs55647940 693 dbSNP
rs1486439193 698 dbSNP
rs971267399 701 dbSNP
rs1254494847 702 dbSNP
rs1461183685 703 dbSNP
rs934461680 703 dbSNP
rs915595525 707 dbSNP
rs925876728 708 dbSNP
rs1042957459 709 dbSNP
rs932544773 712 dbSNP
rs991530772 717 dbSNP
rs1405046733 720 dbSNP
rs1453051798 723 dbSNP
rs1338480095 728 dbSNP
rs867237526 729 dbSNP
rs1385184302 730 dbSNP
rs1222282261 732 dbSNP
rs1359494569 733 dbSNP
rs962495425 735 dbSNP
rs111282581 738 dbSNP
rs1261858453 742 dbSNP
rs1421003159 743 dbSNP
rs1363823286 744 dbSNP
rs1456169747 746 dbSNP
rs1176325669 747 dbSNP
rs1183210072 748 dbSNP
rs1017093591 749 dbSNP
rs1254577450 754 dbSNP
rs1190500374 757 dbSNP
rs751951679 758 dbSNP
rs1428457578 763 dbSNP
rs568845013 768 dbSNP
rs1214659225 769 dbSNP
rs1178238555 770 dbSNP
rs1397925179 777 dbSNP
rs13193266 782 dbSNP
rs943805776 784 dbSNP
rs1297868699 787 dbSNP
rs1374107901 789 dbSNP
rs1029943761 794 dbSNP
rs550737675 798 dbSNP
rs1224734094 800 dbSNP
rs1261352903 801 dbSNP
rs529507727 810 dbSNP
rs1203344344 812 dbSNP
rs1244036182 813 dbSNP
rs1481425337 816 dbSNP
rs764588933 817 dbSNP
rs1196573476 819 dbSNP
rs982957551 822 dbSNP
rs1480718307 824 dbSNP
rs1128261 827 dbSNP
rs1421177678 828 dbSNP
rs1409196897 830 dbSNP
rs900053598 837 dbSNP
rs1355282848 840 dbSNP
rs1415176615 846 dbSNP
rs548207917 847 dbSNP
rs981070082 849 dbSNP
rs1039715125 856 dbSNP
rs1285800792 857 dbSNP
rs1024969777 858 dbSNP
rs1214304965 859 dbSNP
rs1385103884 860 dbSNP
rs73548921 866 dbSNP
rs113123091 872 dbSNP
rs1031015388 881 dbSNP
rs1490383537 884 dbSNP
rs998661996 884 dbSNP
rs1224588692 886 dbSNP
rs10456904 887 dbSNP
rs1043265925 891 dbSNP
rs778329436 898 dbSNP
rs899747519 903 dbSNP
rs1451544028 908 dbSNP
rs1161957918 910 dbSNP
rs1365006800 913 dbSNP
rs777857218 913 dbSNP
rs1425340003 923 dbSNP
rs759715048 938 dbSNP
rs1040738491 943 dbSNP
rs1475749933 946 dbSNP
rs1430645526 947 dbSNP
rs1271130239 952 dbSNP
rs535144704 954 dbSNP
rs1262864726 962 dbSNP
rs370436402 964 dbSNP
rs1243289601 966 dbSNP
rs1052461705 970 dbSNP
rs1313975511 973 dbSNP
rs1359751141 974 dbSNP
rs564828727 979 dbSNP
rs758708781 979 dbSNP
rs1448933541 1008 dbSNP
rs1216485427 1010 dbSNP
rs924426099 1017 dbSNP
rs1045515281 1019 dbSNP
rs1182794075 1027 dbSNP
rs1209312096 1030 dbSNP
rs1445485004 1032 dbSNP
rs950007987 1032 dbSNP
rs915776155 1039 dbSNP
rs1319607525 1042 dbSNP
rs772659301 1042 dbSNP
rs1347284749 1046 dbSNP
rs991211546 1047 dbSNP
rs962685475 1050 dbSNP
rs909662568 1061 dbSNP
rs567837787 1062 dbSNP
rs1233773317 1069 dbSNP
rs748115676 1070 dbSNP
rs1317102762 1071 dbSNP
rs1454249258 1083 dbSNP
rs545859957 1095 dbSNP
rs1349392943 1101 dbSNP
rs1224243936 1102 dbSNP
rs992131426 1109 dbSNP
rs1202737118 1111 dbSNP
rs956679415 1119 dbSNP
rs1461935553 1126 dbSNP
rs1189944019 1129 dbSNP
rs575634151 1131 dbSNP
rs557029717 1135 dbSNP
rs1326644335 1136 dbSNP
rs1414770051 1149 dbSNP
rs1468710957 1149 dbSNP
rs144445877 1150 dbSNP
rs1407376477 1151 dbSNP
rs1397397259 1157 dbSNP
rs1021500120 1183 dbSNP
rs998320597 1190 dbSNP
rs899760258 1195 dbSNP
rs964329240 1198 dbSNP
rs1018938230 1201 dbSNP
rs1384580214 1204 dbSNP
rs1045182 1205 dbSNP
rs893783393 1212 dbSNP
rs1263510638 1214 dbSNP
rs1462394002 1219 dbSNP
rs1325478969 1226 dbSNP
rs772161917 1232 dbSNP
rs1202359450 1236 dbSNP
rs1052493204 1237 dbSNP
rs1271093516 1242 dbSNP
rs886798060 1244 dbSNP
rs534117372 1246 dbSNP
rs1254073306 1249 dbSNP
rs527749937 1257 dbSNP
rs1479739908 1258 dbSNP
rs149653532 1263 dbSNP
rs1045546358 1280 dbSNP
rs931116454 1284 dbSNP
rs919629322 1285 dbSNP
rs1395252793 1305 dbSNP
rs1373861499 1309 dbSNP
rs1309315044 1318 dbSNP
rs1198356504 1322 dbSNP
rs1363228824 1327 dbSNP
rs949922985 1333 dbSNP
rs1404231864 1341 dbSNP
rs533810780 1342 dbSNP
rs1332789331 1349 dbSNP
rs1224903684 1351 dbSNP
rs1269389937 1353 dbSNP
rs1056104785 1358 dbSNP
rs73767710 1362 dbSNP
rs192585221 1363 dbSNP
rs1489891938 1364 dbSNP
rs186926066 1366 dbSNP
rs982416265 1367 dbSNP
rs1270170152 1372 dbSNP
rs1435442062 1372 dbSNP
rs1191402925 1373 dbSNP
rs923974933 1374 dbSNP
rs182194981 1379 dbSNP
rs1197334070 1380 dbSNP
rs1170143064 1386 dbSNP
rs10484837 1387 dbSNP
rs976985010 1404 dbSNP
rs78676083 1410 dbSNP
rs1230558545 1427 dbSNP
rs1018555377 1436 dbSNP
rs990118474 1437 dbSNP
rs1372586052 1446 dbSNP
rs996706503 1448 dbSNP
rs958288409 1450 dbSNP
rs1380460080 1451 dbSNP
rs1317367748 1457 dbSNP
rs779768347 1469 dbSNP
rs1326865670 1478 dbSNP
rs9483 1481 dbSNP
rs1303472563 1483 dbSNP
rs1300047553 1484 dbSNP
rs963850066 1491 dbSNP
rs1245267818 1495 dbSNP
rs568642134 1497 dbSNP
rs906667713 1498 dbSNP
rs887021636 1504 dbSNP
rs1046729307 1519 dbSNP
rs1203956972 1528 dbSNP
rs1327357938 1529 dbSNP
rs1190942112 1545 dbSNP
rs1447972908 1545 dbSNP
rs1382950416 1564 dbSNP
rs530267318 1570 dbSNP
rs191219942 1571 dbSNP
rs1369762716 1576 dbSNP
rs1045189112 1583 dbSNP
rs1014119103 1585 dbSNP
rs1385620633 1586 dbSNP
rs1436950100 1589 dbSNP
rs1412013141 1591 dbSNP
rs894281886 1598 dbSNP
rs947787023 1600 dbSNP
rs1055609397 1602 dbSNP
rs1210054344 1633 dbSNP
rs1172244671 1635 dbSNP
rs1452776975 1646 dbSNP
rs1313521654 1647 dbSNP
rs562835117 1650 dbSNP
rs941288933 1652 dbSNP
rs1194330164 1659 dbSNP
rs755510957 1666 dbSNP
rs1260603901 1668 dbSNP
rs1056547261 1669 dbSNP
rs1439084358 1670 dbSNP
rs1241687267 1673 dbSNP
rs749980762 1681 dbSNP
rs1046766485 1689 dbSNP
rs544553330 1699 dbSNP
rs929625047 1706 dbSNP
rs922379150 1708 dbSNP
rs1183882153 1711 dbSNP
rs1183836137 1723 dbSNP
rs935626556 1727 dbSNP
rs1382640409 1738 dbSNP
rs1364254070 1747 dbSNP
rs1458756297 1748 dbSNP
rs1173987297 1750 dbSNP
rs1405161373 1755 dbSNP
rs73548920 1763 dbSNP
rs1303680434 1777 dbSNP
rs979466083 1788 dbSNP
rs3180226 1792 dbSNP
rs1389691663 1816 dbSNP
rs942904772 1825 dbSNP
rs1351568211 1826 dbSNP
rs1280506753 1827 dbSNP
rs922059204 1832 dbSNP
rs546520636 1840 dbSNP
rs1323336108 1842 dbSNP
rs530762016 1844 dbSNP
rs966105344 1847 dbSNP
rs1479463032 1848 dbSNP
rs1019492743 1851 dbSNP
rs1250702553 1862 dbSNP
rs1473525760 1866 dbSNP
rs989632626 1869 dbSNP
rs1008025461 1875 dbSNP
rs1428305077 1883 dbSNP
rs958287139 1884 dbSNP
rs1361050954 1885 dbSNP
rs369458688 1886 dbSNP
rs1444944163 1887 dbSNP
rs1031212824 1903 dbSNP
rs1297675042 1910 dbSNP
rs951284494 1919 dbSNP
rs563348468 1921 dbSNP
rs1025953198 1922 dbSNP
rs1333902721 1925 dbSNP
rs1220121137 1926 dbSNP
rs115785635 1929 dbSNP
rs1305400631 1932 dbSNP
rs1377501043 1934 dbSNP
rs898177793 1937 dbSNP
rs1023285048 1938 dbSNP
rs1219653752 1939 dbSNP
rs1268027455 1942 dbSNP
rs1192640322 1947 dbSNP
rs934950835 1947 dbSNP
rs896234913 1954 dbSNP
rs10484838 1956 dbSNP
rs1390831655 1971 dbSNP
rs1025082345 1974 dbSNP
rs186404405 1984 dbSNP
rs1301388482 1990 dbSNP
rs1178915617 1993 dbSNP
rs1470456934 1997 dbSNP
rs566344638 2003 dbSNP
rs902779369 2005 dbSNP
rs1295641666 2010 dbSNP
rs1360378739 2013 dbSNP
rs1213598893 2015 dbSNP
rs1185524588 2031 dbSNP
rs549449066 2033 dbSNP
rs1297830150 2034 dbSNP
rs183668323 2036 dbSNP
rs1034604762 2038 dbSNP
rs946971809 2039 dbSNP
rs759961271 2040 dbSNP
rs573034514 2044 dbSNP
rs1005345588 2047 dbSNP
rs1240121258 2074 dbSNP
rs1257797620 2084 dbSNP
rs1215378708 2086 dbSNP
rs1451566889 2088 dbSNP
rs921956469 2108 dbSNP
rs974764265 2108 dbSNP
rs1406441069 2112 dbSNP
rs944811841 2114 dbSNP
rs78062676 2117 dbSNP
rs150546088 2118 dbSNP
rs1352018550 2130 dbSNP
rs1047005213 2131 dbSNP
rs1450092120 2137 dbSNP
rs753943756 2153 dbSNP
rs568831648 2160 dbSNP
rs951168931 2163 dbSNP
rs900818538 2173 dbSNP
rs1229577074 2174 dbSNP
rs1025455657 2182 dbSNP
rs974423870 2195 dbSNP
rs1316284574 2204 dbSNP
rs141673529 2224 dbSNP
rs1269861287 2227 dbSNP
rs1023758870 2255 dbSNP
rs1182034853 2266 dbSNP
rs73767709 2277 dbSNP
rs1473146295 2280 dbSNP
rs1183697565 2284 dbSNP
rs896249687 2291 dbSNP
rs1343556891 2299 dbSNP
rs1391356965 2309 dbSNP
rs529451801 2313 dbSNP
rs1161357493 2318 dbSNP
rs760626747 2324 dbSNP
rs1335719672 2325 dbSNP
rs1340729637 2326 dbSNP
rs910937431 2342 dbSNP
rs1412982846 2354 dbSNP
rs1277270638 2359 dbSNP
rs1162630535 2363 dbSNP
rs1476077382 2366 dbSNP
rs138976771 2370 dbSNP
rs1192539503 2374 dbSNP
rs1269764200 2375 dbSNP
rs1321210435 2377 dbSNP
rs1202835638 2380 dbSNP
rs1484676424 2384 dbSNP
rs534901091 2385 dbSNP
rs1043887635 2387 dbSNP
rs866525240 2394 dbSNP
rs1183595331 2401 dbSNP
rs978297191 2410 dbSNP
rs1450473292 2413 dbSNP
rs1273126495 2415 dbSNP
rs970931584 2417 dbSNP
rs571025849 2420 dbSNP
rs562701012 2425 dbSNP
rs1479637809 2426 dbSNP
rs990802533 2432 dbSNP
rs773475573 2433 dbSNP
rs900751719 2436 dbSNP
rs552551823 2442 dbSNP
rs1016345861 2446 dbSNP
rs944661153 2448 dbSNP
rs1369456107 2449 dbSNP
rs1410328387 2457 dbSNP
rs1005422542 2488 dbSNP
rs1431586910 2495 dbSNP
rs911996949 2499 dbSNP
rs1349322734 2501 dbSNP
rs1222617237 2502 dbSNP
rs531254329 2510 dbSNP
rs1345968021 2512 dbSNP
rs929392087 2516 dbSNP
rs1270940563 2520 dbSNP
rs1482792091 2523 dbSNP
rs762673005 2533 dbSNP
rs752109258 2535 dbSNP
rs1169678203 2537 dbSNP
rs1254531036 2539 dbSNP
rs1426441859 2549 dbSNP
rs1490006734 2556 dbSNP
rs1421218049 2557 dbSNP
rs764827589 2557 dbSNP
rs1198593031 2562 dbSNP
rs1186691121 2564 dbSNP
rs1478794527 2591 dbSNP
rs1477423556 2593 dbSNP
rs1250560261 2596 dbSNP
rs1429776332 2597 dbSNP
rs1212419454 2599 dbSNP
rs1309335061 2603 dbSNP
rs1363560961 2607 dbSNP
rs191884743 2616 dbSNP
rs1323958464 2636 dbSNP
rs1386210940 2636 dbSNP
rs1470207566 2637 dbSNP
rs1332664167 2651 dbSNP
rs918448162 2653 dbSNP
rs759098075 2655 dbSNP
rs962948707 2657 dbSNP
rs1229160416 2676 dbSNP
rs112930174 2681 dbSNP
rs1357906902 2682 dbSNP
rs1209819060 2685 dbSNP
rs1268456758 2686 dbSNP
rs1204272106 2688 dbSNP
rs563317623 2689 dbSNP
rs960340797 2693 dbSNP
rs1034631479 2696 dbSNP
rs1194287162 2700 dbSNP
rs1367047371 2708 dbSNP
rs1301311463 2718 dbSNP
rs1449264581 2719 dbSNP
rs386408358 2719 dbSNP
rs544654693 2719 dbSNP
rs774826667 2719 dbSNP
rs1319660254 2722 dbSNP
rs1364646217 2725 dbSNP
rs1443089855 2728 dbSNP
rs901058730 2729 dbSNP
rs1395122201 2734 dbSNP
rs999261312 2736 dbSNP
rs1041113380 2739 dbSNP
rs1359088561 2744 dbSNP
rs1006558011 2750 dbSNP
rs1267964715 2751 dbSNP
rs889568959 2757 dbSNP
rs866280827 2762 dbSNP
rs1053530323 2763 dbSNP
rs1022924660 2767 dbSNP
rs1422691472 2768 dbSNP
rs1187668372 2769 dbSNP
rs1460293189 2771 dbSNP
rs35449434 2771 dbSNP
rs1356015522 2773 dbSNP
rs1370061140 2774 dbSNP
rs936866017 2777 dbSNP
rs186634946 2792 dbSNP
rs1457936558 2803 dbSNP
rs1322760231 2813 dbSNP
rs772104775 2814 dbSNP
rs1377271875 2815 dbSNP
rs530072824 2818 dbSNP
rs1395465783 2820 dbSNP
rs1042505773 2824 dbSNP
rs551013501 2825 dbSNP
rs146113443 2827 dbSNP
rs890487586 2835 dbSNP
rs1288094117 2847 dbSNP
rs1047751725 2852 dbSNP
rs545796088 2856 dbSNP
rs1253836769 2860 dbSNP
rs1482732856 2873 dbSNP
rs1479880414 2883 dbSNP
rs1200463165 2891 dbSNP
rs1253415853 2893 dbSNP
rs1257740449 2901 dbSNP
rs1417213780 2901 dbSNP
rs1181414386 2902 dbSNP
rs920648172 2903 dbSNP
rs959392844 2912 dbSNP
rs113337314 2921 dbSNP
rs1357573168 2929 dbSNP
rs984852968 2930 dbSNP
rs572904573 2935 dbSNP
rs1025492879 2942 dbSNP
rs972524776 2951 dbSNP
rs1404507199 2952 dbSNP
rs965716821 2960 dbSNP
rs1019522847 2962 dbSNP
rs990722136 2967 dbSNP
rs564316087 2978 dbSNP
rs1006998159 2980 dbSNP
rs1230559418 2981 dbSNP
rs1299650635 2986 dbSNP
rs2498702 2988 dbSNP
rs1031945197 2989 dbSNP
rs1233582387 2992 dbSNP
rs1257211396 3002 dbSNP
rs1481762496 3008 dbSNP
rs1236596642 3012 dbSNP
rs1252373322 3012 dbSNP
rs575587812 3017 dbSNP
rs768275503 3019 dbSNP
rs1042536613 3022 dbSNP
rs949552428 3023 dbSNP
rs1197005988 3025 dbSNP
rs1424268516 3029 dbSNP
rs181424910 3032 dbSNP
rs966865073 3033 dbSNP
rs188471879 3040 dbSNP
rs1168053816 3042 dbSNP
rs938031849 3049 dbSNP
rs574530006 3058 dbSNP
rs1412300603 3060 dbSNP
rs964929614 3063 dbSNP
rs1367393423 3065 dbSNP
rs143817285 3070 dbSNP
rs1465291174 3081 dbSNP
rs534722550 3082 dbSNP
rs1387740498 3094 dbSNP
rs1302890631 3095 dbSNP
rs1339648951 3098 dbSNP
rs1373241732 3106 dbSNP
rs1274815645 3107 dbSNP
rs929381557 3132 dbSNP
rs1434820185 3136 dbSNP
rs6568926 3137 dbSNP
rs1488664399 3144 dbSNP
rs540769134 3146 dbSNP
rs1192730475 3150 dbSNP
rs1418656398 3154 dbSNP
rs1255059716 3157 dbSNP
rs1447894546 3159 dbSNP
rs1168034352 3160 dbSNP
rs1159065592 3161 dbSNP
rs1390930249 3164 dbSNP
rs972597967 3166 dbSNP
rs1417831371 3178 dbSNP
rs1253177181 3180 dbSNP
rs745356667 3181 dbSNP
rs1458679739 3186 dbSNP
rs552761593 3193 dbSNP
rs991647743 3199 dbSNP
rs1295653777 3200 dbSNP
rs6568925 3201 dbSNP
rs570000615 3205 dbSNP
rs370468326 3206 dbSNP
rs1297663948 3213 dbSNP
rs758899726 3221 dbSNP
rs954070435 3225 dbSNP
rs948799312 3227 dbSNP
rs1236859297 3228 dbSNP
rs1031975783 3233 dbSNP
rs916445918 3235 dbSNP
rs1318649133 3236 dbSNP
rs1054877663 3241 dbSNP
rs1307536280 3242 dbSNP
rs1463701674 3243 dbSNP
rs1188222939 3245 dbSNP
rs939312319 3249 dbSNP
rs927845755 3259 dbSNP
rs1035760799 3261 dbSNP
rs1314363108 3262 dbSNP
rs978169141 3272 dbSNP
rs966379151 3274 dbSNP
rs1383679461 3278 dbSNP
rs914872987 3279 dbSNP
rs989272945 3283 dbSNP
rs1456347521 3295 dbSNP
rs1000449847 3297 dbSNP
rs1474194078 3301 dbSNP
rs1445101592 3302 dbSNP
rs1366064053 3314 dbSNP
rs964447085 3318 dbSNP
rs753258902 3319 dbSNP
rs1017824049 3326 dbSNP
rs987596315 3338 dbSNP
rs1160398252 3340 dbSNP
rs548513955 3342 dbSNP
rs867168760 3355 dbSNP
rs1268936474 3364 dbSNP
rs1190387124 3372 dbSNP
rs1448959780 3373 dbSNP
rs993926500 3376 dbSNP
rs1486111833 3379 dbSNP
rs1261205923 3384 dbSNP
rs530034769 3393 dbSNP
rs1486854679 3410 dbSNP
rs1261263263 3411 dbSNP
rs1472443113 3425 dbSNP
rs779399428 3428 dbSNP
rs755261156 3430 dbSNP
rs1055676377 3432 dbSNP
rs6568924 3433 dbSNP
rs1233587440 3435 dbSNP
rs1412469061 3436 dbSNP
rs1332919494 3446 dbSNP
rs1325484771 3449 dbSNP
rs1359286366 3453 dbSNP
rs1315707648 3456 dbSNP
rs887992758 3457 dbSNP
rs1450091135 3458 dbSNP
rs374414316 3459 dbSNP
rs185177520 3462 dbSNP
rs919372011 3464 dbSNP
rs180820388 3469 dbSNP
rs1217737900 3478 dbSNP
rs1277959859 3482 dbSNP
rs1443030853 3491 dbSNP
rs1461354674 3495 dbSNP
rs1042330918 3497 dbSNP
rs1392808317 3499 dbSNP
rs545963037 3512 dbSNP
rs766491560 3514 dbSNP
rs1476824687 3522 dbSNP
rs869182330 3526 dbSNP
rs1191238784 3528 dbSNP
rs1435978039 3529 dbSNP
rs912412214 3533 dbSNP
rs1166175974 3534 dbSNP
rs370288073 3538 dbSNP
rs953990135 3542 dbSNP
rs1262478897 3544 dbSNP
rs1435533729 3545 dbSNP
rs563569163 3547 dbSNP
rs1274440110 3548 dbSNP
rs925200898 3550 dbSNP
rs1345997392 3551 dbSNP
rs1236505665 3553 dbSNP
rs979100320 3556 dbSNP
rs1272658712 3560 dbSNP
rs1467075565 3567 dbSNP
rs545739121 3577 dbSNP
rs372998160 3594 dbSNP
rs1450196079 3595 dbSNP
rs1013353556 3605 dbSNP
rs1198612863 3623 dbSNP
rs960705552 3630 dbSNP
rs1455358527 3644 dbSNP
rs1214102241 3646 dbSNP
rs987649784 3647 dbSNP
rs772115787 3648 dbSNP
rs1430292034 3649 dbSNP
rs1169535322 3655 dbSNP
rs1388514163 3655 dbSNP
rs1033857317 3656 dbSNP
rs1002742356 3657 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7259.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aggacuGGGGAUCUGGGUUGAc 5'
                |||:|   ||||||| 
Target 5' ccccucCCCUUCUUCCCAACUu 3'
 		1 - 22
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_003309 | 3UTR | UAGAGCUCUUACGCCCCUCCCCUUCUUCCCAACUUCCUACUUCCUAGCCCUUUUAUCAACUCCUAGAAUAGUUAAAGAGAGACACAUCUAGAUGGGAUGAAAGGUGCCCUAAGCAGGAGAAACUGAACAAAAGGCUAGAGGCAUGGGCCAGGUAAAAAUUGGGCCUAGAGUGAAGACUGUGCUGUCGUUAAGAGCUUUCGAGGAAGGAGUACUUACUCCCCAAUGAUGAUGAAUGGAAAAAUACUUUUCAGGGAGAAUUGAAGGGGUUAAAGUGUUAAAUAUGUUGCCUAGACAAGGGUUCUUUAAAGAAAGACAGCGCAACUUUGAAUGCUUUCUUACUUGUUUUGUGACCUAAUUUAUGUGGAAGAUUGUUAUUUCAUUAGGAUUUAGUAAAAUUUUUUUUUCUGAUUCUAAACUUAUUGUGAAAAUUGAGCUGUACAGAUAUUCUUUUGAUUUCAAUUGGGAACAUUUGGAAGAACAACAGUCUUACUUGCCUGUACAAUAUAGAGACAUAUGAAUAGUCAUAACAGUUUUCAACUUGUUCUUGUUUCUGUUAAACUAUAUUCCUAGAAACAUAGUUUGAACAACUUGGUCUUUGUUAGGCUUGUCAAAUUGCCUUCAUGGAAAAAUAAUCUACAAAAGUAUGGUUUAAUUGAUUGUCUUACAUGAUAAUUUUCCCUGGUAACAACUUAGUAAGUGAUAUAUCUUUUUUCCUAAAUUGCUUAAAUACUGUGAAAUUGCUCUGACAAAUUGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_003309 | 3UTR | AGCUCUUACGCCCCUCCCCUUCUUCCCAACUUCCUACUUCCUAGCCCUUUUAUCAACUCCUAGAAUAGUUAAAGAGAGACACAUCUAGAUGGGAUGAAAGGUGCCCUAAGCAGGAGAAACUGAACAAAAGGCUAGAGGCAUGGGCCAGGUAAAAAUUGGGCCUAGAGUGAAGACUGUGCUGUCGUUAAGAGCUUUCGAGGAAGGAGUACUUACUCCCCAAUGAUGAUGAAUGGAAAAAUACUUUUCAGGGAGAAUUGAAGGGGUUAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_003309 | 3UTR | GAGCUCUUACGCCCCUCCCCUUCUUCCCAACUUCCUACUUCCUAGCCCUUUUAUCAACUCCUAGAAUAGUUAAAGAGAGACACAUCUAGAUGGGAUGAAAGGUGCCCUAAGCAGGAGAAACUGAACAAAAGGCUAGAGGCAUGGGCCAGGUAAAAAUUGGGCCUAGAGUGAAGACUGUGCUGUCGUUAAGAGCUUUCGAGGAAGGAGUACUUACUCCCCAAUGAUGAUGAAUGGAAAAAUACUUUUCAGGGAGAAUUGAAGGGGUUAAAGUGUUAAAUAUGUUGCCUAGACAAGGGUUCUUUAAAGAAAGACAGCGCAACUUUGAAUGCUUUCUUACUUGUUUUGUGACCUAAUUUAUGUGGAAGAUUGUUAUUUCAUUAGGAUUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_003309 | 3UTR | CUUCUUCCCAACUUCCUACUUCCUAGCCCUUUUAUCAACUCCUAGAAUAGUUAAAGAGAGACACAUCUAGAUGGGAUGAAAGGUGCCCUAAGCAGGAGAAACUGAACAAAAGGCUAGAGGCAUGGGCCAGGUAAAAAUUGGGCCUAGAGUGAAGACUGUGCUGUCGUUAAGAGCUUUCGAGGAAGGAGUACUUACUCCCCAAUGAUGAUGAAUGGAAAAAUACUUUUCAGGGAGAAUUGAAGGGGUUAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_003309 | 3UTR | CCUUCUUCCCAACUUCCUACUUCCUAGCCCUUUUAUCAACUCCUAGAAUAGUUAAAGAGAGACACAUCUAGAUGGGAUGAAAGGUGCCCUAAGCAGGAGAAACUGAACAAAAGGCUAGAGGCAUGGGCCAGGUAAAAAUUGGGCCUAGAGUGAAGACUGUGCUGUCGUUAAGAGCUUUCGAGGAAGGAGUACUUACUCCCCAAUGAUGAUGAAUGGAAAAAUACUUUUCAGGGAGAAUUGAAGGGGUUAAAGUGUUAAAUAUGUUGCCUAGACAAGGGUUCUUUAAAGAAAGACAGCGCAACUUUGAAUGCUUUCUUACUUGUUUUGUGACCUAAUUUAUGUGGAAGAUUGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_003309 | 3UTR | CUUACGCCCCUCCCCUUCUUCCCAACUUCCUACUUCCUAGCCCUUUUAUCAACUCCUAGAAUAGUUAAAGAGAGACACAUCUAGAUGGGAUGAAAGGUGCCCUAAGCAGGAGAAACUGAACAAAAGGCUAGAGGCAUGGGCCAGGUAAAAAUUGGGCCUAGAGUGAAGACUGUGCUGUCGUUAAGAGCUUUCGAGGAAGGAGUACUUACUCCCCAAUGAUGAUGAAUGGAAAAAUACUUUUCAGGGAGAAUUGAAGGGGUUAAAGUGUUAAAUAUGUUGCCUAGACAAGGGUUCUUUAAAGAAAGACAGCGCAACUUUGAAUGCUUUCUUACUUGUUUUGUGACCUAAUUUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000368608.3 | 3UTR | CCCCUCCCCUUCUUCCCAACUUCCUACUUCCUAGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
40 hsa-miR-4259 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074403 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT082380 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 6
MIRT224489 NDRG1 N-myc downstream regulated 1 2 2
MIRT227807 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT293253 DR1 down-regulator of transcription 1 2 2
MIRT455060 MEN1 menin 1 2 2
MIRT459206 RCE1 Ras converting CAAX endopeptidase 1 2 2
MIRT464866 UBB ubiquitin B 2 8
MIRT464897 UBALD1 UBA like domain containing 1 2 2
MIRT467210 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT467749 SLC36A1 solute carrier family 36 member 1 2 2
MIRT470565 POU2F1 POU class 2 homeobox 1 2 2
MIRT473523 MAX MYC associated factor X 2 2
MIRT474955 KCTD10 potassium channel tetramerization domain containing 10 2 4
MIRT478575 CTNND1 catenin delta 1 2 2
MIRT479952 CBX4 chromobox 4 2 6
MIRT486151 SIX5 SIX homeobox 5 2 6
MIRT488836 MRRF mitochondrial ribosome recycling factor 2 2
MIRT489466 MSC musculin 2 2
MIRT498922 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT501166 SLC10A7 solute carrier family 10 member 7 2 6
MIRT504195 FAM127B retrotransposon Gag like 8A 2 2
MIRT507342 FAM168A family with sequence similarity 168 member A 2 2
MIRT512629 GPX1 glutathione peroxidase 1 2 4
MIRT514365 UBBP4 ubiquitin B pseudogene 4 2 6
MIRT523321 H3F3B H3 histone family member 3B 2 2
MIRT529793 AP4S1 adaptor related protein complex 4 sigma 1 subunit 2 2
MIRT544301 TSPYL1 TSPY like 1 2 2
MIRT552985 VAT1 vesicle amine transport 1 2 2
MIRT562785 LIMA1 LIM domain and actin binding 1 2 2
MIRT653090 SSR3 signal sequence receptor subunit 3 2 2
MIRT661985 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 4
MIRT666982 PHAX phosphorylated adaptor for RNA export 2 2
MIRT683255 WFDC6 WAP four-disulfide core domain 6 2 2
MIRT684051 FOLR1 folate receptor 1 2 2
MIRT686137 B4GALT7 beta-1,4-galactosyltransferase 7 2 2
MIRT688435 DNAL1 dynein axonemal light chain 1 2 2
MIRT698391 TMED2 transmembrane p24 trafficking protein 2 2 2
MIRT698819 STK38 serine/threonine kinase 38 2 2
MIRT715754 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4259 Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4259 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4259 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4259 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4259 Temozolomide 5394 NSC362856 approved resistant High Glioblastoma cell line (U251)
hsa-mir-4259 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4259 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4259 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4259 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4259 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4259 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4259 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4259 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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