miRTarBase - #MIRT544656


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pre-miRNA Information
pre-miRNA hsa-mir-516b-1   
Genomic Coordinates chr19: 53736845 - 53736934
Synonyms MIRN516-4, MIRN516B-1, MIRN516B1, MIR516B1
Description Homo sapiens miR-516b-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-516b-2   
Genomic Coordinates chr19: 53725442 - 53725526
Synonyms MIRN516-3, MIRN516B-2, MIRN516B2, MIR516B2
Description Homo sapiens miR-516b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-516b-3p
Sequence 56| UGCUUCCUUUCAGAGGGU |73
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413434631 1 dbSNP
rs746170707 2 dbSNP
rs1312744198 2 dbSNP
rs752101959 3 dbSNP
rs770077784 4 dbSNP
rs1193425541 6 dbSNP
rs953142850 7 dbSNP
rs1020245150 7 dbSNP
rs775845942 11 dbSNP
rs1402471980 11 dbSNP
rs760158839 15 dbSNP
rs78861479 16 dbSNP
rs765933705 16 dbSNP
Putative Targets

Gene Information
Gene Symbol MED19   
Synonyms DT2P1G7, LCMR1, MED19AS
Description mediator complex subunit 19
Transcript NM_153450   
Expression
Putative miRNA Targets on MED19
3'UTR of MED19
(miRNA target sites are highlighted)		 
>MED19|NM_153450|3'UTR
   1 GTTCCGTATGGAGCTCTGGACTCCTAAATTCCCCTGAAGAAGAAACCAATGTACTGTGGTCTCTTGGGACTTGGGACAGG
  81 GACTCTAGCAGCACCTCTGTATCCTTTCTGGCCATTTGGACAAAAGCAGTTGCCCCGACTTGGGATTTTCCTGTAGTCTT
 161 CAGTGGTTCATAACAGTAGAGGATTTTGAGCTTTACAGGTGATAGGTACCTAATGTCTCCTACAGAAACACCATCTGATT
 241 CAGATCACAAGAAGAAGAAAAAGAAAAAAGAAGAGGATCCTGAACGGAAAAGGAAGAAGAAAGAGAAGAAGAAAAAGAAG
 321 GTAGAGTAGAGGCCTATTGCCACAACCCAGTGAGTTTCCCCAGATCTCACCCCTGTCCTAAATACCCTAGAGTTCTTTGC
 401 CTCAAGTTGGACCCAAGATTGAAAACCCAAGGCAGGTTGCAGGTTTCTCCTGTACAGCCTGATCAAAGCCAAGGCTAGTT
 481 CCTAGTTGTTCTTACCCTGCTTCTTTCTCCCCCAGAATCGACATAGTCCAGACCACCCAGGTATGGGCAGCTCCCAGGCC
 561 AGCAGCAGCAGCAGCCTACGCTAATAGGACCACTGGACTCTTTGCCAGGATGGCTTTTCCTGCTGTACTGAACCTGCTGA
 641 TAAAAGCTGCCTTCCAGGCTCTTGGACACTGCCTTGGGAGCATCCTGCAGCTGGGACAGAGGCCAGCTCCTGTTGGGCTC
 721 AGTTGAGACTAAGTAAATTAGGAGAGAGAGGGACATGCTTTTGTAGGCTCATCCCAGTTGGTTTTCTCATGGACATCTCT
 801 TCCTCTCCCAGGAAGCTTACAATTTTCTTCTCTCTCTTTTGTGCAATTTGTCTGATTTAGGACTTGTTCTGTGTTTTCTT
 881 TAAAAAAAAAAAAATTACATTTATCAAACTGGCAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugGGAGACUUUCCUUCGu 5'
            |||||   ||||||| 
Target 5' ttCCTCTCCCAGGAAGCt 3'
 800 - 817 156.00 -17.30
2 
miRNA  3' ugGGA---GAC-UUUCCUUCgu 5'
            |||   | | ||||||||  
Target 5' atCCTGAACGGAAAAGGAAGaa 3'
 277 - 298 132.00 -11.80
3 
miRNA  3' ugGGAGACUUUCCU-UCGu 5'
            :||:||  |||| :|| 
Target 5' acTCTTTGCCAGGATGGCt 3'
 597 - 615 108.00 -14.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26984124 6 COSMIC
COSN26984126 10 COSMIC
COSN26984125 13 COSMIC
COSN30128823 20 COSMIC
COSN30458323 24 COSMIC
COSN31510587 27 COSMIC
COSN31597684 54 COSMIC
COSN30467923 66 COSMIC
COSN30510741 67 COSMIC
COSN30508864 79 COSMIC
COSN31503331 95 COSMIC
COSN30150081 98 COSMIC
COSN19647530 111 COSMIC
COSN30121741 148 COSMIC
COSN31492896 190 COSMIC
COSM3788005 238 COSMIC
COSM6237496 263 COSMIC
COSM7333450 267 COSMIC
COSM8546469 286 COSMIC
COSN26564879 348 COSMIC
COSN24381398 354 COSMIC
COSN31559561 440 COSMIC
COSM9349017 541 COSMIC
COSM7326902 560 COSMIC
COSM9322044 567 COSMIC
COSM1604771 575 COSMIC
COSM3769366 579 COSMIC
COSN31593399 656 COSMIC
COSN28838063 658 COSMIC
COSN30109699 678 COSMIC
COSN30164325 699 COSMIC
COSN16520643 881 COSMIC
COSN27450403 881 COSMIC
COSN28936418 882 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769846600 3 dbSNP
rs1182621694 4 dbSNP
rs748252197 5 dbSNP
rs374282109 6 dbSNP
rs769207054 9 dbSNP
rs116551129 14 dbSNP
rs1280067420 18 dbSNP
rs780449675 19 dbSNP
rs758896717 23 dbSNP
rs748917569 25 dbSNP
rs777617012 30 dbSNP
rs755635488 31 dbSNP
rs671954 39 dbSNP
rs671957 42 dbSNP
rs1284390827 48 dbSNP
rs1198572782 61 dbSNP
rs1005865173 71 dbSNP
rs1477900656 80 dbSNP
rs1446906481 102 dbSNP
rs1427870296 104 dbSNP
rs891256877 105 dbSNP
rs1469130877 115 dbSNP
rs1193415756 124 dbSNP
rs888306362 126 dbSNP
rs1047309178 132 dbSNP
rs371072172 136 dbSNP
rs1483641587 137 dbSNP
rs549956681 138 dbSNP
rs1407427884 139 dbSNP
rs1400037680 148 dbSNP
rs1318382855 153 dbSNP
rs994264181 156 dbSNP
rs1441302282 158 dbSNP
rs147292664 169 dbSNP
rs138359660 170 dbSNP
rs35168157 172 dbSNP
rs757993073 172 dbSNP
rs776084550 172 dbSNP
rs1328965216 174 dbSNP
rs1284157129 177 dbSNP
rs767301762 178 dbSNP
rs1342396319 182 dbSNP
rs754932817 183 dbSNP
rs1349410543 184 dbSNP
rs1226042355 186 dbSNP
rs1434732806 187 dbSNP
rs1389634837 194 dbSNP
rs1161567323 203 dbSNP
rs751519392 205 dbSNP
rs936334395 209 dbSNP
rs1411304078 210 dbSNP
rs924989184 217 dbSNP
rs766167823 219 dbSNP
rs1238741089 233 dbSNP
rs1186116306 235 dbSNP
rs1464004422 236 dbSNP
rs1240364712 241 dbSNP
rs1045173940 245 dbSNP
rs1437679051 251 dbSNP
rs1271482084 254 dbSNP
rs1248267447 257 dbSNP
rs1210161641 263 dbSNP
rs1450263089 270 dbSNP
rs1419891398 272 dbSNP
rs1289593915 275 dbSNP
rs1461930293 276 dbSNP
rs1162410214 281 dbSNP
rs1229438877 289 dbSNP
rs1359075330 293 dbSNP
rs1268546882 301 dbSNP
rs1392767902 302 dbSNP
rs770199032 302 dbSNP
rs1334815461 305 dbSNP
rs541926524 314 dbSNP
rs1365930794 325 dbSNP
rs1322839042 326 dbSNP
rs1368305959 327 dbSNP
rs917719464 329 dbSNP
rs1336083192 332 dbSNP
rs1438917367 334 dbSNP
rs529997749 336 dbSNP
rs1322612491 337 dbSNP
rs991986585 341 dbSNP
rs559312167 342 dbSNP
rs901294268 347 dbSNP
rs1415893891 354 dbSNP
rs1166567679 355 dbSNP
rs1448383483 360 dbSNP
rs113697206 361 dbSNP
rs1190169424 362 dbSNP
rs765477410 363 dbSNP
rs1173120532 366 dbSNP
rs911193578 368 dbSNP
rs1190117343 375 dbSNP
rs1258378374 390 dbSNP
rs1475485774 395 dbSNP
rs974022921 406 dbSNP
rs1366646994 417 dbSNP
rs149429767 419 dbSNP
rs777218562 420 dbSNP
rs936888772 427 dbSNP
rs1369509028 430 dbSNP
rs1355849046 436 dbSNP
rs1427483744 437 dbSNP
rs1314168811 442 dbSNP
rs867028978 443 dbSNP
rs1355618219 451 dbSNP
rs1413639969 453 dbSNP
rs978191451 455 dbSNP
rs557801347 464 dbSNP
rs1222759214 469 dbSNP
rs1453624139 475 dbSNP
rs1273110809 486 dbSNP
rs868571564 487 dbSNP
rs992524567 488 dbSNP
rs761816904 495 dbSNP
rs958423939 496 dbSNP
rs955504162 502 dbSNP
rs1367165625 506 dbSNP
rs1274089627 507 dbSNP
rs776782929 509 dbSNP
rs1351365575 512 dbSNP
rs1306132415 513 dbSNP
rs1010391871 514 dbSNP
rs1005482149 519 dbSNP
rs1169936970 533 dbSNP
rs1431155546 535 dbSNP
rs1424050575 536 dbSNP
rs1191343497 539 dbSNP
rs545947460 541 dbSNP
rs1479225598 546 dbSNP
rs1250001510 554 dbSNP
rs1182152144 557 dbSNP
rs1483648992 566 dbSNP
rs1175059208 567 dbSNP
rs1276944084 569 dbSNP
rs1208094374 573 dbSNP
rs1375696285 576 dbSNP
rs746751678 576 dbSNP
rs1311611160 579 dbSNP
rs1279642829 580 dbSNP
rs1221107429 584 dbSNP
rs1347223106 585 dbSNP
rs768673842 586 dbSNP
rs952706456 587 dbSNP
rs1409208648 588 dbSNP
rs1025487795 591 dbSNP
rs1309715805 592 dbSNP
rs761236602 593 dbSNP
rs900991532 603 dbSNP
rs772895894 604 dbSNP
rs1176357172 605 dbSNP
rs1041172860 606 dbSNP
rs1415795853 613 dbSNP
rs1410265387 616 dbSNP
rs1181902668 622 dbSNP
rs1387739482 624 dbSNP
rs772542476 625 dbSNP
rs1297304078 627 dbSNP
rs1254610946 630 dbSNP
rs575532480 633 dbSNP
rs1236960445 634 dbSNP
rs1304364027 639 dbSNP
rs1283041898 642 dbSNP
rs1347454462 657 dbSNP
rs1231104720 662 dbSNP
rs891999238 678 dbSNP
rs1486801194 679 dbSNP
rs1205718270 680 dbSNP
rs1006954524 690 dbSNP
rs1054633757 702 dbSNP
rs1000407539 703 dbSNP
rs1195291661 707 dbSNP
rs903499949 709 dbSNP
rs1432276703 712 dbSNP
rs1365093576 713 dbSNP
rs1454759116 714 dbSNP
rs771115258 725 dbSNP
rs1445404147 747 dbSNP
rs371408207 751 dbSNP
rs374625420 751 dbSNP
rs1387105052 756 dbSNP
rs1443498712 757 dbSNP
rs889806358 760 dbSNP
rs947733408 763 dbSNP
rs1390305895 764 dbSNP
rs896222638 768 dbSNP
rs1322986378 773 dbSNP
rs1054161943 775 dbSNP
rs747127002 786 dbSNP
rs936940714 789 dbSNP
rs1267377144 794 dbSNP
rs557048633 795 dbSNP
rs1327038802 796 dbSNP
rs140029905 819 dbSNP
rs1253446550 820 dbSNP
rs947888 821 dbSNP
rs1487946415 827 dbSNP
rs1189164816 832 dbSNP
rs778139280 837 dbSNP
rs1252232649 838 dbSNP
rs1419091519 838 dbSNP
rs918068690 838 dbSNP
rs1410341490 843 dbSNP
rs947887 845 dbSNP
rs1166073577 846 dbSNP
rs184384363 850 dbSNP
rs1181285267 851 dbSNP
rs1374361858 856 dbSNP
rs3187643 870 dbSNP
rs552928627 871 dbSNP
rs985461078 872 dbSNP
rs1348534160 874 dbSNP
rs1235124263 878 dbSNP
rs1250116851 879 dbSNP
rs55674685 881 dbSNP
rs1189047090 882 dbSNP
rs56324148 882 dbSNP
rs1320820001 889 dbSNP
rs1219125892 891 dbSNP
rs1029740147 895 dbSNP
rs570253487 895 dbSNP
rs937059551 895 dbSNP
rs955588565 895 dbSNP
rs758753381 896 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 219541.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000337672.2 | 3UTR | CUUACAAUUUUCUUCUCUCUCUUUUGUGCAAUUUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000337672.2 | 3UTR | CUUACAAUUUUCUUCUCUCUCUUUUGUGCAAUUUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease 0.185 1.9e-1 0.185 1.9e-1 25 Click to see details
GSE17306 Multiple myeloma 0.077 3.0e-1 0.336 9.1e-3 49 Click to see details
GSE27834 Pluripotent stem cells -0.142 3.0e-1 0.015 4.8e-1 16 Click to see details
GSE32688 Pancreatic cancer 0.085 3.2e-1 0.023 4.5e-1 32 Click to see details
GSE21849 B cell lymphoma -0.005 4.9e-1 0.092 3.2e-1 29 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
85 hsa-miR-516b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT077049 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT155261 IFNAR2 interferon alpha and beta receptor subunit 2 2 4
MIRT446119 ASTN1 astrotactin 1 2 2
MIRT447355 STOM stomatin 2 2
MIRT469329 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT470201 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT475944 GXYLT1 glucoside xylosyltransferase 1 2 4
MIRT498268 KIAA1644 KIAA1644 2 2
MIRT501725 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT522860 KIAA1551 KIAA1551 2 2
MIRT527900 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT528557 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT531250 PDF peptide deformylase, mitochondrial 2 2
MIRT534410 SENP1 SUMO1/sentrin specific peptidase 1 2 2
MIRT544656 MED19 mediator complex subunit 19 2 2
MIRT550681 YARS tyrosyl-tRNA synthetase 2 2
MIRT557208 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 4
MIRT611532 DDB1 damage specific DNA binding protein 1 2 2
MIRT612087 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT616535 PARD6B par-6 family cell polarity regulator beta 2 4
MIRT616738 DCTN5 dynactin subunit 5 2 2
MIRT616754 SVOP SV2 related protein 2 4
MIRT617380 FAM227A family with sequence similarity 227 member A 2 2
MIRT617624 RAB3IP RAB3A interacting protein 2 2
MIRT620778 MT1A metallothionein 1A 2 2
MIRT623172 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT626034 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT627376 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT630533 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT631686 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT633896 FGF10 fibroblast growth factor 10 2 2
MIRT635933 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636275 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT636285 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT636502 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT638037 SHPK sedoheptulokinase 2 2
MIRT639162 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT639571 GORASP1 golgi reassembly stacking protein 1 2 2
MIRT641248 CENPN centromere protein N 2 2
MIRT643650 MYOCD myocardin 2 2
MIRT645490 TRIM63 tripartite motif containing 63 2 2
MIRT648016 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT648102 LRRFIP1 LRR binding FLII interacting protein 1 2 2
MIRT648729 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT650177 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT652787 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT653248 SORD sorbitol dehydrogenase 2 2
MIRT654859 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT655533 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656390 MCU mitochondrial calcium uniporter 2 2
MIRT656881 KIF1C kinesin family member 1C 2 2
MIRT657083 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657629 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT658295 FAM83F family with sequence similarity 83 member F 2 2
MIRT659432 COL1A1 collagen type I alpha 1 chain 2 2
MIRT659791 CBLB Cbl proto-oncogene B 2 2
MIRT660153 BRCC3 BRCA1/BRCA2-containing complex subunit 3 2 2
MIRT660490 ARRDC3 arrestin domain containing 3 2 2
MIRT660503 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT666356 SIKE1 suppressor of IKBKE 1 2 2
MIRT677774 FKTN fukutin 2 2
MIRT688556 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT697415 ZFP91 ZFP91 zinc finger protein 2 2
MIRT709468 KRTAP19-1 keratin associated protein 19-1 2 2
MIRT711154 WDR82P1 WD repeat domain 82 pseudogene 1 2 2
MIRT711467 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT712515 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT712661 PCTP phosphatidylcholine transfer protein 2 2
MIRT713304 TYRP1 tyrosinase related protein 1 2 2
MIRT714597 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT716603 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT717537 PYGO2 pygopus family PHD finger 2 2 2
MIRT718058 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT718539 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719768 ZNF236 zinc finger protein 236 2 2
MIRT720162 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT720360 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT721182 HOPX HOP homeobox 2 2
MIRT721278 RAD54L2 RAD54 like 2 2 2
MIRT721357 ENTHD1 ENTH domain containing 1 2 2
MIRT721504 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721918 LINGO2 leucine rich repeat and Ig domain containing 2 2 2
MIRT722278 LURAP1 leucine rich adaptor protein 1 2 2
MIRT722789 FUT4 fucosyltransferase 4 2 2
MIRT724390 ABAT 4-aminobutyrate aminotransferase 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-516b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-516b Bromocriptine approved 31101 Microarray Prolactinoma 22366961 2012 up-regulated
miR-516b Bromocriptine approved 31101 Quantitative real-time PCR Prolactinoma 22366961 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-516b-3p Paclitaxel 36314 NSC125973 approved sensitive High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-516b-3p Ribavirin+Pegylated IFNa-2b sensitive tissue (chronic hepatitis C)
hsa-miR-516b-3p Testosterone+Exemestane sensitive cell line (MCF-7)
hsa-miR-516b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-516b-3p Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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