pre-miRNA Information
pre-miRNA hsa-mir-873   
Genomic Coordinates chr9: 28888879 - 28888955
Synonyms MIRN873, hsa-mir-873, MIR873
Description Homo sapiens miR-873 stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-873-3p
Sequence 46| GGAGACUGAUGAGUUCCCGGGA |67
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760528397 3 dbSNP
rs773403294 9 dbSNP
rs1273846238 13 dbSNP
rs1339396073 15 dbSNP
rs1247999695 18 dbSNP
rs377380148 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CSTF2T   
Synonyms CstF-64T
Description cleavage stimulation factor subunit 2 tau variant
Transcript NM_015235   
Expression
Putative miRNA Targets on CSTF2T
3'UTR of CSTF2T
(miRNA target sites are highlighted)
>CSTF2T|NM_015235|3'UTR
   1 AAGGTTTTAGAAAATATTTGGCTGTAGTCTCAAATTTTATTCTGTAGCATGGAGAATGGGTGCAAAAAGCTGACTTCTGT
  81 ATCCCCACACTTGGATTAGGGTTTCCCTCCTCCTAGAACCTAATCTTATTTTTTGTTCTTTTTCTTTCTTTCTGTTTTCC
 161 TTTTTTTTTTAATTGAGGGTGGGGGGAGGAGGGAGTGCGTCTGTTCACTTTAAGTTACTTTAAAATAACTCTGAACATGA
 241 TTATATTATGCCAAATAAGATTACAAAGAATAAGCAGCAATATTGAAGCATCTACAGTATGTTAACTACATTTTTTAAAT
 321 GTCGAGTAAAACTTCGTGAAAACTGCTCATAAAGACTAAAAGTTGACCTGTTAAAACGTTAATGTACTAAGATAGTTTTA
 401 AGATTTTTGGTTGTATAACAAAATAAAAGTTTACCCAAAAGTATAAGATACATTTTTTGGTAAACCATTTAAAATACAAA
 481 ATCCTATTTTGGAGGCAATAGGATAAGCATTGTCTTAGTGTTTTAGAATTATTTTTGAAACAGAGTTAACAGGATAAGGT
 561 TACACTTGTATTAGAATTGTTTTTTTCTAAAGTTATGTTACCTGAAAAATCAAGGAGTGCACCTGATTTACTGTTGCTTC
 641 ATTTATCCCATCCTTCAGAGACCAGCAAGGTTCTGCCAGGCCCCAAGCATCTGAGCATGATGATTTTGCTGTGACAATTC
 721 TAAGATCAACCAGGTTACTTAAGTCCGCTCTGATGAAACCCAGTCTCTCAATACCTTCCTATTTCTCAATAGTCTTTAAG
 801 CCCTAAATCTGAGTCAGTAATTCTCTAAAAATCCTTCCCAAAAATCAGTGTCTAGGGACTGGTTGATCTAGATGAGTTAT
 881 AAATGGTATTTGACTTTTCATAAGTAGTGGAAGGTTTCACTAAGTAAAGATCTGAGTTTCTTGGTATCTGACGTTTGTAT
 961 ACAGATGGTGTCCATTTGCTCAACCAGACAGGAGTTAACTTGTATTAGAATTGTTTTTTCTAAAGTTATGTTACCTGAGA
1041 AATTAAGGACTGCACCTGGTTTAATGTTGCTTCACTTATCCCACCCTACAGAGACCAGCAAGGTTCTGCCAGGCCTCGAG
1121 CATCCAAGCATGATTTTGCTGTGACAAATCTAAAATCAACCAGGCTACTTAAGTCTGCTCTGATGAAACCCAATAATCTC
1201 TCAATACCTTCCTATTTCTCAATAGTCTTTAAACCCTAAATCTGAGTCAGTAATTCTCTTACATCCTTCCCAAAAATCAG
1281 TGTCTAGGGACTAGTTGATCTGGATGAGTTATACATGATATTTGACTTTTCATAAGTAGTGGAAGGTTTCACTAAGTAAA
1361 ACTCTCAGTTTCTTGGTATCTGGCTTTCTTATACAGATGGTGTCCATTTGCTCCACCAGACAGGAGTTAAAAACCTTTAA
1441 AGAGCATTTAACATGCCTTTTAGTTTTCTTATTTCATAATCTACTTTTCTATCATTAATCATCTTACCAGGAATAATCAA
1521 GGCCCAGGTAGGTAGAAGTTTTTATATAGCCTGAATACTCACTTGACTTACTGCTCATTTTACTTTTTGCATGGAATACA
1601 GCCATTTAGTCCTAATATACATACCAATGAGACAATTAAAAATTGGTTGGAAGATGGAGCTTATCACATTGTGCTACTAC
1681 GACTTTATTTTTTCTTGAAAATAAAGCCTTGAGGATGTGAACATAAATGTTGGTATCATAAAACAAGTAGTAATAAAAGC
1761 ATAAATTATCAAATATCAGGTGATCTTACTATGGAGAAGAAAAACCAATATCTAGTTACAGATGAAAAAATGTTTAATAC
1841 AAAGAGCTGAAAATGTAGAAATTGAGTTATCTTCCCTTTGCAAAATTTTTACACTTTAAATTAGTAATTCTTTGTTTGCA
1921 AGGTTTTCATCCCTATGCTGTTGTTTTCTACTACCTGTTTTACTCTTGTTCATACTGCTACTTTCCCATGTTTCCTATAT
2001 GCCTCCCCTATATTGGAGAGGATAACTCGCGTTTACATATGTGATAGTTATGCTTAATACTAATTCACAGAGTTGGCTCG
2081 ATCATTTTGAGATTCTAGTTGCTTTATCTCAAAGCTTTCACTGAAGGGCTGTAACTGAAAATTATTAAATGTTAGTCTTT
2161 AGTCAAATCTCTGCATTGTTTCATGCAGAAAATAAAGATACAATTAAGGCTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agggcccUUGAGUAGUCAGAGg 5'
                 ||||| |||||:|| 
Target 5' taagtaaAACTC-TCAGTTTCt 3'
1353 - 1373 146.00 -15.20
2
miRNA  3' agGGC--CCUUGAGUAGUCAGAGg 5'
            |:|  | ||| |  ||||||| 
Target 5' ctCTGATGAAAC-C--CAGTCTCt 3'
748 - 768 145.00 -12.80
3
miRNA  3' agggcccuuGAGUAGUCAGAGg 5'
                   |||| :|||||: 
Target 5' ttcctatttCTCAATAGTCTTt 3'
776 - 797 125.00 -14.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31552922 5 COSMIC
COSN15658420 7 COSMIC
COSN31582276 10 COSMIC
COSN26972146 41 COSMIC
COSN30492036 58 COSMIC
COSN30127634 77 COSMIC
COSN31524119 80 COSMIC
COSN26972148 81 COSMIC
COSN30127635 85 COSMIC
COSN32053005 112 COSMIC
COSN31498413 138 COSMIC
COSN30140541 139 COSMIC
COSN30705819 148 COSMIC
COSN20107105 161 COSMIC
COSN23606389 198 COSMIC
COSN30127748 205 COSMIC
COSN8711362 915 COSMIC
COSN15124437 962 COSMIC
COSN21503867 1055 COSMIC
COSN6973041 1086 COSMIC
COSN17210860 1093 COSMIC
COSN22903877 1154 COSMIC
COSN20107104 1437 COSMIC
COSN25931172 1687 COSMIC
COSN31646289 2197 COSMIC
rs14168 1897 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763289523 3 dbSNP
rs1235717345 9 dbSNP
rs757108476 11 dbSNP
rs753632908 15 dbSNP
rs763957208 17 dbSNP
rs1327257425 18 dbSNP
rs759639363 20 dbSNP
rs1383729331 23 dbSNP
rs751830434 24 dbSNP
rs766347859 29 dbSNP
rs763061471 38 dbSNP
rs1332899876 39 dbSNP
rs1235332075 44 dbSNP
rs375932725 45 dbSNP
rs1273944264 52 dbSNP
rs140943180 63 dbSNP
rs1214357831 69 dbSNP
rs924701077 74 dbSNP
rs1486403965 81 dbSNP
rs1043087392 92 dbSNP
rs947422212 99 dbSNP
rs557534493 104 dbSNP
rs915872436 106 dbSNP
rs1166634042 108 dbSNP
rs1418033705 110 dbSNP
rs1345856369 115 dbSNP
rs1316151437 122 dbSNP
rs1320577823 128 dbSNP
rs770329927 129 dbSNP
rs572448215 137 dbSNP
rs1418072145 138 dbSNP
rs1431242654 147 dbSNP
rs991485630 148 dbSNP
rs918258323 154 dbSNP
rs973803541 154 dbSNP
rs796317370 162 dbSNP
rs962475101 165 dbSNP
rs937956590 169 dbSNP
rs747587915 170 dbSNP
rs1210006849 171 dbSNP
rs1286979535 171 dbSNP
rs139403403 171 dbSNP
rs537541770 172 dbSNP
rs961162425 181 dbSNP
rs367823598 183 dbSNP
rs1189632066 185 dbSNP
rs1257709186 187 dbSNP
rs1427109580 187 dbSNP
rs548585998 194 dbSNP
rs1477449816 195 dbSNP
rs1409490788 197 dbSNP
rs773843170 198 dbSNP
rs568925720 199 dbSNP
rs1195464481 204 dbSNP
rs1416318735 206 dbSNP
rs1313725204 207 dbSNP
rs1350049435 212 dbSNP
rs1440148818 212 dbSNP
rs952430988 217 dbSNP
rs1285756047 225 dbSNP
rs748874228 227 dbSNP
rs1350523140 229 dbSNP
rs375755078 229 dbSNP
rs1350483326 231 dbSNP
rs1280638367 233 dbSNP
rs182181937 237 dbSNP
rs1000903918 245 dbSNP
rs1470194212 248 dbSNP
rs1192934713 249 dbSNP
rs996517803 266 dbSNP
rs1219124875 267 dbSNP
rs1436377263 280 dbSNP
rs901461692 283 dbSNP
rs755829142 289 dbSNP
rs1395480514 290 dbSNP
rs1408491360 297 dbSNP
rs1271952376 299 dbSNP
rs1398417445 305 dbSNP
rs1336436352 309 dbSNP
rs1340045327 310 dbSNP
rs1435779128 322 dbSNP
rs1301910465 324 dbSNP
rs7908187 325 dbSNP
rs566264949 333 dbSNP
rs11601 335 dbSNP
rs751757473 336 dbSNP
rs1360680243 346 dbSNP
rs942834824 349 dbSNP
rs529479702 354 dbSNP
rs563529892 359 dbSNP
rs1051322464 362 dbSNP
rs1419644966 363 dbSNP
rs1212464770 367 dbSNP
rs73343318 368 dbSNP
rs947480294 378 dbSNP
rs1476642188 381 dbSNP
rs1262088426 382 dbSNP
rs1188209623 383 dbSNP
rs1484465733 389 dbSNP
rs745331818 396 dbSNP
rs1236063386 399 dbSNP
rs894544948 400 dbSNP
rs1308556601 414 dbSNP
rs1169887316 415 dbSNP
rs1397419969 424 dbSNP
rs1260082053 429 dbSNP
rs1324016894 435 dbSNP
rs1396759877 441 dbSNP
rs1442354468 443 dbSNP
rs973771094 445 dbSNP
rs1056235824 449 dbSNP
rs1412740058 452 dbSNP
rs1229996435 459 dbSNP
rs1325052088 459 dbSNP
rs1271587384 471 dbSNP
rs1339609097 482 dbSNP
rs938696673 483 dbSNP
rs962445091 486 dbSNP
rs1317361944 488 dbSNP
rs560368042 499 dbSNP
rs1270791408 500 dbSNP
rs1294207342 510 dbSNP
rs1214254967 517 dbSNP
rs2339815 524 dbSNP
rs1416827227 525 dbSNP
rs1260891385 532 dbSNP
rs1445091181 537 dbSNP
rs1373401385 543 dbSNP
rs1381141416 543 dbSNP
rs927870809 545 dbSNP
rs772638495 546 dbSNP
rs1163035772 549 dbSNP
rs981993139 551 dbSNP
rs532894504 555 dbSNP
rs1184873738 565 dbSNP
rs867017678 569 dbSNP
rs1461967901 577 dbSNP
rs1158510378 580 dbSNP
rs1447243903 583 dbSNP
rs546908092 586 dbSNP
rs529817271 588 dbSNP
rs971230334 589 dbSNP
rs908353345 592 dbSNP
rs1491289582 596 dbSNP
rs752820805 596 dbSNP
rs1491369496 597 dbSNP
rs1233316214 598 dbSNP
rs952599236 602 dbSNP
rs1348505923 606 dbSNP
rs1028070047 610 dbSNP
rs975487445 611 dbSNP
rs964979276 613 dbSNP
rs1186079890 617 dbSNP
rs1259804196 619 dbSNP
rs1019835073 621 dbSNP
rs1158423690 626 dbSNP
rs1362100930 631 dbSNP
rs1165256087 632 dbSNP
rs7916579 633 dbSNP
rs1030952979 636 dbSNP
rs1412116008 640 dbSNP
rs1433188518 642 dbSNP
rs571987008 650 dbSNP
rs1310723750 651 dbSNP
rs903425053 658 dbSNP
rs1481254578 661 dbSNP
rs1396220874 670 dbSNP
rs1305735043 679 dbSNP
rs1240638349 682 dbSNP
rs1333465801 683 dbSNP
rs555410926 684 dbSNP
rs533070489 686 dbSNP
rs1346898369 697 dbSNP
rs1007400733 701 dbSNP
rs894594090 702 dbSNP
rs142914640 705 dbSNP
rs1247293607 710 dbSNP
rs1320102627 711 dbSNP
rs1248577259 715 dbSNP
rs556393681 717 dbSNP
rs117136630 727 dbSNP
rs897434618 730 dbSNP
rs1046366299 737 dbSNP
rs760079734 742 dbSNP
rs41305705 746 dbSNP
rs908446771 747 dbSNP
rs1175963476 750 dbSNP
rs1376422534 757 dbSNP
rs940965796 762 dbSNP
rs761154331 769 dbSNP
rs1297244607 770 dbSNP
rs1048744579 771 dbSNP
rs1373779570 773 dbSNP
rs1333325577 775 dbSNP
rs148650617 785 dbSNP
rs558202391 787 dbSNP
rs1305411919 789 dbSNP
rs114755068 794 dbSNP
rs1459124663 799 dbSNP
rs917087184 807 dbSNP
rs1481673689 815 dbSNP
rs1196418008 825 dbSNP
rs1252419993 840 dbSNP
rs190347507 852 dbSNP
rs16921608 860 dbSNP
rs1396135779 861 dbSNP
rs868616577 862 dbSNP
rs1169323948 866 dbSNP
rs1370935645 876 dbSNP
rs749005741 876 dbSNP
rs1463097819 879 dbSNP
rs1032853907 885 dbSNP
rs912251586 890 dbSNP
rs779038832 891 dbSNP
rs978668716 915 dbSNP
rs1368059621 924 dbSNP
rs774959366 940 dbSNP
rs1382523813 950 dbSNP
rs769648093 952 dbSNP
rs549306246 953 dbSNP
rs967635947 964 dbSNP
rs1272688499 970 dbSNP
rs1467191982 982 dbSNP
rs1253742041 983 dbSNP
rs1216104921 996 dbSNP
rs1247741183 1000 dbSNP
rs185713831 1002 dbSNP
rs1018257406 1008 dbSNP
rs1264259096 1015 dbSNP
rs1429977778 1020 dbSNP
rs1170928961 1028 dbSNP
rs755219842 1029 dbSNP
rs1459365065 1030 dbSNP
rs149460133 1032 dbSNP
rs1265148768 1039 dbSNP
rs1216725091 1042 dbSNP
rs1354206584 1044 dbSNP
rs180671912 1046 dbSNP
rs891242116 1047 dbSNP
rs1237909259 1050 dbSNP
rs796660163 1054 dbSNP
rs1375970574 1059 dbSNP
rs1301376386 1064 dbSNP
rs533542900 1069 dbSNP
rs1292834377 1070 dbSNP
rs1388070248 1075 dbSNP
rs1364873278 1080 dbSNP
rs958870600 1081 dbSNP
rs1292626400 1083 dbSNP
rs1453977968 1084 dbSNP
rs1034863207 1086 dbSNP
rs1362873120 1088 dbSNP
rs569745437 1103 dbSNP
rs35249954 1104 dbSNP
rs564056334 1112 dbSNP
rs547456545 1115 dbSNP
rs1473958325 1117 dbSNP
rs1396154828 1118 dbSNP
rs1413859272 1121 dbSNP
rs35869827 1138 dbSNP
rs1400109531 1139 dbSNP
rs1156836371 1148 dbSNP
rs1038607249 1159 dbSNP
rs1420026277 1167 dbSNP
rs1036394129 1168 dbSNP
rs1353749506 1174 dbSNP
rs905509683 1176 dbSNP
rs757322539 1177 dbSNP
rs1289579052 1185 dbSNP
rs887026451 1189 dbSNP
rs1048272821 1193 dbSNP
rs949822651 1195 dbSNP
rs1286874668 1202 dbSNP
rs916952626 1206 dbSNP
rs527339517 1221 dbSNP
rs921082980 1222 dbSNP
rs561666634 1239 dbSNP
rs925804071 1242 dbSNP
rs1287898975 1244 dbSNP
rs1237620813 1249 dbSNP
rs1039921882 1260 dbSNP
rs1175428724 1262 dbSNP
rs978637756 1264 dbSNP
rs964620558 1265 dbSNP
rs1172819409 1270 dbSNP
rs753808049 1272 dbSNP
rs1436879966 1276 dbSNP
rs1335097409 1279 dbSNP
rs1440037753 1284 dbSNP
rs1281814687 1300 dbSNP
rs1378346520 1312 dbSNP
rs985896635 1318 dbSNP
rs541802881 1332 dbSNP
rs576411350 1336 dbSNP
rs977097542 1339 dbSNP
rs562522304 1357 dbSNP
rs955409242 1358 dbSNP
rs778030720 1359 dbSNP
rs758359970 1364 dbSNP
rs575705138 1365 dbSNP
rs1192915440 1366 dbSNP
rs1296753771 1367 dbSNP
rs1478848314 1371 dbSNP
rs1173389629 1378 dbSNP
rs1408398591 1382 dbSNP
rs1419027266 1382 dbSNP
rs1399852226 1383 dbSNP
rs1403315776 1385 dbSNP
rs914818938 1387 dbSNP
rs562734741 1388 dbSNP
rs1174875159 1389 dbSNP
rs752976401 1391 dbSNP
rs959147080 1392 dbSNP
rs546040255 1411 dbSNP
rs116357941 1413 dbSNP
rs188365307 1416 dbSNP
rs1193213708 1421 dbSNP
rs545155801 1427 dbSNP
rs113063983 1440 dbSNP
rs113758518 1440 dbSNP
rs368228136 1440 dbSNP
rs1017138532 1442 dbSNP
rs1256569251 1443 dbSNP
rs1202130537 1456 dbSNP
rs761086149 1457 dbSNP
rs1342741629 1469 dbSNP
rs1228313141 1470 dbSNP
rs1173090006 1471 dbSNP
rs1424439961 1475 dbSNP
rs1254912058 1478 dbSNP
rs971507361 1483 dbSNP
rs1393467963 1485 dbSNP
rs1387824670 1491 dbSNP
rs1318128153 1492 dbSNP
rs1319375159 1494 dbSNP
rs184020815 1499 dbSNP
rs1428293090 1513 dbSNP
rs1014977549 1514 dbSNP
rs1004894485 1533 dbSNP
rs887755560 1538 dbSNP
rs572396903 1542 dbSNP
rs377029256 1544 dbSNP
rs577199524 1544 dbSNP
rs1014300719 1546 dbSNP
rs1358446378 1546 dbSNP
rs755221284 1549 dbSNP
rs1336509665 1550 dbSNP
rs555350411 1554 dbSNP
rs1264114050 1561 dbSNP
rs1394805280 1562 dbSNP
rs1027334486 1565 dbSNP
rs1370242825 1577 dbSNP
rs1332614185 1579 dbSNP
rs754255455 1583 dbSNP
rs899731484 1584 dbSNP
rs925768320 1586 dbSNP
rs146280304 1589 dbSNP
rs576100516 1593 dbSNP
rs16921605 1597 dbSNP
rs117456834 1611 dbSNP
rs890879918 1612 dbSNP
rs1041415935 1617 dbSNP
rs750892718 1618 dbSNP
rs1368868982 1623 dbSNP
rs1413766547 1624 dbSNP
rs571017857 1625 dbSNP
rs762202700 1627 dbSNP
rs990204952 1630 dbSNP
rs191733426 1632 dbSNP
rs1255461307 1635 dbSNP
rs1348309877 1636 dbSNP
rs1218470787 1648 dbSNP
rs16921604 1656 dbSNP
rs973214770 1668 dbSNP
rs1208980807 1670 dbSNP
rs561723230 1680 dbSNP
rs981646441 1681 dbSNP
rs1181737683 1687 dbSNP
rs1362514231 1687 dbSNP
rs548221591 1711 dbSNP
rs1197655036 1715 dbSNP
rs1356527289 1716 dbSNP
rs1005690901 1722 dbSNP
rs775214253 1730 dbSNP
rs1243144373 1732 dbSNP
rs531302615 1737 dbSNP
rs769401327 1740 dbSNP
rs1396062976 1753 dbSNP
rs983511717 1753 dbSNP
rs1023616688 1759 dbSNP
rs952209563 1760 dbSNP
rs1309781994 1780 dbSNP
rs1232371041 1785 dbSNP
rs1027681828 1788 dbSNP
rs1483632744 1798 dbSNP
rs1310682047 1808 dbSNP
rs562797104 1812 dbSNP
rs1014523531 1814 dbSNP
rs1248468508 1824 dbSNP
rs895461342 1826 dbSNP
rs1449625523 1827 dbSNP
rs1394862172 1832 dbSNP
rs1452900941 1834 dbSNP
rs1052814950 1839 dbSNP
rs546061300 1842 dbSNP
rs904312319 1852 dbSNP
rs1297154927 1854 dbSNP
rs540166587 1860 dbSNP
rs1448988894 1866 dbSNP
rs577003757 1879 dbSNP
rs1369990345 1889 dbSNP
rs1008024830 1892 dbSNP
rs14168 1897 dbSNP
rs1226951396 1903 dbSNP
rs1256315232 1904 dbSNP
rs1320009864 1910 dbSNP
rs1052087549 1919 dbSNP
rs1199836734 1919 dbSNP
rs1467444103 1923 dbSNP
rs1041467984 1935 dbSNP
rs945841011 1941 dbSNP
rs892864320 1947 dbSNP
rs1169303283 1954 dbSNP
rs1420837246 1955 dbSNP
rs759311534 1955 dbSNP
rs540006407 1962 dbSNP
rs1171324907 1965 dbSNP
rs937000759 1974 dbSNP
rs775971684 1979 dbSNP
rs927537284 1986 dbSNP
rs909929099 1997 dbSNP
rs1295118304 2007 dbSNP
rs770540671 2010 dbSNP
rs1368038107 2012 dbSNP
rs984225644 2013 dbSNP
rs1276475081 2015 dbSNP
rs1235830743 2028 dbSNP
rs141882960 2029 dbSNP
rs950215737 2030 dbSNP
rs187285576 2031 dbSNP
rs1224414739 2038 dbSNP
rs1266467956 2039 dbSNP
rs960355946 2041 dbSNP
rs1045767 2051 dbSNP
rs952193853 2052 dbSNP
rs1028150623 2058 dbSNP
rs1193802766 2067 dbSNP
rs1416493649 2070 dbSNP
rs1403603195 2078 dbSNP
rs748240511 2079 dbSNP
rs1007275470 2080 dbSNP
rs1452724951 2084 dbSNP
rs888934063 2105 dbSNP
rs1362738680 2111 dbSNP
rs556242432 2131 dbSNP
rs1018162483 2135 dbSNP
rs1292814627 2142 dbSNP
rs138751969 2144 dbSNP
rs1308644861 2145 dbSNP
rs1230527689 2152 dbSNP
rs777704440 2155 dbSNP
rs1313988029 2160 dbSNP
rs185169340 2167 dbSNP
rs897707261 2173 dbSNP
rs1036284872 2175 dbSNP
rs1489095038 2180 dbSNP
rs939980378 2182 dbSNP
rs74132567 2183 dbSNP
rs1471490479 2184 dbSNP
rs1020103377 2198 dbSNP
rs755199985 2203 dbSNP
rs1010478167 2204 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 23283.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000331173.4 | 3UTR | UCUCAAAUUUUAUUCUGUAGCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000331173.4 | 3UTR | UCUCAAAUUUUAUUCUGUAGCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-873-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081178 MIDN midnolin 2 4
MIRT109809 ZFX zinc finger protein, X-linked 2 4
MIRT242383 TMC5 transmembrane channel like 5 2 4
MIRT444003 METRN meteorin, glial cell differentiation regulator 2 4
MIRT444097 SEPHS1 selenophosphate synthetase 1 2 2
MIRT446158 RPL12 ribosomal protein L12 2 2
MIRT446859 SAMD9L sterile alpha motif domain containing 9 like 2 2
MIRT447275 FZD5 frizzled class receptor 5 2 2
MIRT447391 TMPRSS15 transmembrane protease, serine 15 2 2
MIRT448817 FKBP1A FK506 binding protein 1A 2 4
MIRT450582 HIST1H2BG histone cluster 1 H2B family member g 2 2
MIRT451776 USP36 ubiquitin specific peptidase 36 2 2
MIRT457961 ABCC5 ATP binding cassette subfamily C member 5 2 4
MIRT458424 KLHL38 kelch like family member 38 2 4
MIRT461383 SLFN12L schlafen family member 12 like 2 2
MIRT467793 SLC2A14 solute carrier family 2 member 14 2 2
MIRT476517 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT480290 C7orf73 short transmembrane mitochondrial protein 1 2 4
MIRT482745 HES7 hes family bHLH transcription factor 7 2 10
MIRT483189 HIST1H2AH histone cluster 1 H2A family member h 2 6
MIRT486545 DCTN4 dynactin subunit 4 2 2
MIRT486581 ZNF619 zinc finger protein 619 2 2
MIRT492604 POLR3E RNA polymerase III subunit E 2 2
MIRT494130 DCAF7 DDB1 and CUL4 associated factor 7 2 6
MIRT496023 ZBED3 zinc finger BED-type containing 3 2 2
MIRT497121 NBEAL1 neurobeachin like 1 2 2
MIRT497400 TMEM245 transmembrane protein 245 2 2
MIRT501410 RANBP10 RAN binding protein 10 2 2
MIRT510947 PPTC7 PTC7 protein phosphatase homolog 2 6
MIRT512494 ARID2 AT-rich interaction domain 2 2 2
MIRT512595 ZNF783 zinc finger family member 783 2 2
MIRT512612 CNTN4 contactin 4 2 2
MIRT517808 UGDH UDP-glucose 6-dehydrogenase 2 6
MIRT520686 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT526179 HEPH hephaestin 2 2
MIRT532568 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT533979 TADA2A transcriptional adaptor 2A 2 2
MIRT538622 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539703 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT539806 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT540422 FAM83F family with sequence similarity 83 member F 2 2
MIRT540506 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT540619 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT542423 ZNF331 zinc finger protein 331 2 2
MIRT542454 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT543383 CC2D2A coiled-coil and C2 domain containing 2A 2 2
MIRT544777 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT544923 ERCC4 ERCC excision repair 4, endonuclease catalytic subunit 2 2
MIRT549768 ZNF611 zinc finger protein 611 2 4
MIRT551242 COLEC10 collectin subfamily member 10 2 2
MIRT560474 ENSA endosulfine alpha 2 2
MIRT569738 GPR173 G protein-coupled receptor 173 2 2
MIRT571297 CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2 2
MIRT572345 CKAP2L cytoskeleton associated protein 2 like 2 2
MIRT573112 ERBB2IP erbb2 interacting protein 2 2
MIRT607744 ANGPT4 angiopoietin 4 2 2
MIRT607903 SPRYD4 SPRY domain containing 4 2 2
MIRT611744 SERPING1 serpin family G member 1 2 4
MIRT615101 BNC2 basonuclin 2 2 2
MIRT619124 CD40LG CD40 ligand 2 2
MIRT625572 ANKRD42 ankyrin repeat domain 42 2 2
MIRT629038 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633986 SLC35E2 solute carrier family 35 member E2 2 2
MIRT635675 COX18 COX18, cytochrome c oxidase assembly factor 2 4
MIRT637471 DEFB105B defensin beta 105B 2 4
MIRT637503 DEFB105A defensin beta 105A 2 4
MIRT639735 MAP2K2 mitogen-activated protein kinase kinase 2 2 2
MIRT640730 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT645364 C9orf47 chromosome 9 open reading frame 47 2 2
MIRT647938 RNF152 ring finger protein 152 2 2
MIRT649400 SH2D4A SH2 domain containing 4A 2 2
MIRT656860 KIN Kin17 DNA and RNA binding protein 2 2
MIRT663470 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT663507 NKAPL NFKB activating protein like 2 4
MIRT667690 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT677403 PCNP PEST proteolytic signal containing nuclear protein 2 2
MIRT678682 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT678789 NUPL2 nucleoporin like 2 2 2
MIRT680649 KIAA1456 KIAA1456 2 2
MIRT682450 MTX3 metaxin 3 2 2
MIRT682740 CA6 carbonic anhydrase 6 2 2
MIRT684421 TUFT1 tuftelin 1 2 2
MIRT690535 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT690595 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT690771 PLA2G2C phospholipase A2 group IIC 2 2
MIRT692233 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT693667 MXRA7 matrix remodeling associated 7 2 2
MIRT695551 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT695870 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT696214 LYZ lysozyme 2 2
MIRT698368 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT700795 PHTF2 putative homeodomain transcription factor 2 2 2
MIRT701640 MYLK3 myosin light chain kinase 3 2 2
MIRT702989 HERPUD2 HERPUD family member 2 2 2
MIRT703627 FBXL3 F-box and leucine rich repeat protein 3 2 2
MIRT703783 FAM102B family with sequence similarity 102 member B 2 2
MIRT704293 DDX19B DEAD-box helicase 19B 2 2
MIRT704828 CDC73 cell division cycle 73 2 2
MIRT705014 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT708480 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT710770 PHF7 PHD finger protein 7 2 2
MIRT718918 TRIM66 tripartite motif containing 66 2 2
MIRT720390 ZNF549 zinc finger protein 549 2 2
MIRT720593 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT723515 SIGLEC8 sialic acid binding Ig like lectin 8 2 2
MIRT724458 PRKX protein kinase, X-linked 2 2
MIRT737267 UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 3 0
MIRT737356 ZIC2 Zic family member 2 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-873 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-873 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-873 Cisplatin 5460033 NSC119875 approved resistant cell line (OE19)
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-873 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-873-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-873-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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