miRTarBase - #MIRT544892


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pre-miRNA Information
pre-miRNA hsa-mir-4301   
Genomic Coordinates chr11: 113450023 - 113450088
Description Homo sapiens miR-4301 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4301
Sequence 11| UCCCACUACUUCACUUGUGA |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs184176277 2 dbSNP
rs1191324913 13 dbSNP
rs1369198005 15 dbSNP
rs1036973189 16 dbSNP
rs944900541 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol OSBPL1A   
Synonyms ORP-1, ORP1, OSBPL1B
Description oxysterol binding protein like 1A
Transcript NM_018030   
Other Transcripts NM_080597   
Expression
Putative miRNA Targets on OSBPL1A
3'UTR of OSBPL1A
(miRNA target sites are highlighted)		 
>OSBPL1A|NM_018030|3'UTR
   1 AATGCATACAAGTCAGGGTGTTTGGCTAATCTACAAATAAGTCTTAAACCTATGTTTTTAAATTTTTTTCCCTTGGTTTC
  81 TACTTATCTTTTAAAAAAAAAAATGAAAAAACACTCATGAGATAACTGCATTTCACCCAACAAAAGCAGGGTATAAGGCG
 161 ATATTGGTGATGAAAGTCTTAGGAAAAATGCATAATTTTGCTATAAAATGTACTTATTTGGAATACTATTTTATATAGAG
 241 GTAAGAGAACACTGCTGGGGAATATGCTTTTTATGGTTGCTGTTGCCATATTTACTGAAGGTTTATACCTAAATGTAACT
 321 TTAGCTTTATGGAACTATATAGTAATCCCAAATCAAGTTATTTTGAATATTTTTATGCTGTCATGCTTGAATGTTTTAGA
 401 TGTAACCTTTGACATATTTAGAACTCTCCTCCTATACAATGTTTATTCTCAGATATAGAGGTTATGTCATTTTATAAAGA
 481 CTTCATTGATAAGATGGCTTTTATTCATACTAATCCTCCCAATGTTACCCCTTCCATCTTCCAAGAAGAAAAAAAATGCC
 561 TGAATATTCAGAATAGATATTTCTGATTTGAAAATTCTAAAGAATTAAACTGGAAAAGTATTTCATTTACTTAGTGCTCT
 641 GAATTTACTTTTACAGTTTTCTGCAGTCAGTATCATTAAAATGGTTAAGTTTACATTTGAACTGAAAATATGTATAAAAT
 721 CTAGCAATTCACAAAAATGCCCTAGAAATATAGATTTTAATCACCATTACATAATGACAAACCTTGTTAAATGCTTCCAC
 801 TTCCAGTGGCAAATGCCACTAGGGAAAGTAAGTTGCACTCATGTAAGTATCAAACTATATAAAAGGAGGCCTTGTGCATT
 881 TCAAGTTTGCAAAGTACCTGTGTACTTAAAATATGTGTGGAGACCTACTGTACAGTAGTTTTGCCCCTTTAATTGGGGCA
 961 CATTCATCTTAAATCTTATAGTATTTATCCACCCAAACCCCAGACTGAGATACTGCTCCCAGGGGCCTAGGTAGCTGCCA
1041 GTCCGTGATTTTAATTGCTGTCTTGAAGTTAACAAGTGTTATAATGAAATAATCTACCTGATGCTAAATAAAGGCTTTAG
1121 AATGTTCCCCAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUGUUCACU--UCAUCACCCu 5'
            ::||| ||  | |: |||| 
Target 5' agGTAAGAGAACACTGCTGGGg 3'
 239 - 260 108.00 -8.60
2 
miRNA  3' agUGUUCACUUCAUCACCcu 5'
            |:||| | : || |||  
Target 5' gtATAAG-GCGATATTGGtg 3'
 151 - 169 101.00 -8.70
3 
miRNA  3' aguguucacuucaUCACCcu 5'
                       |||||  
Target 5' tgcttccacttccAGTGGca 3'
 792 - 811 100.00 -5.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30187851 8 COSMIC
COSN30523693 16 COSMIC
COSN30144843 32 COSMIC
COSN26644367 34 COSMIC
COSN31511077 34 COSMIC
COSN26566481 43 COSMIC
COSN30132958 62 COSMIC
COSN13762784 92 COSMIC
COSN20114806 93 COSMIC
COSN20114814 93 COSMIC
COSN509841 93 COSMIC
COSN15660387 210 COSMIC
COSN28015557 751 COSMIC
COSN8248589 843 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1213894036 3 dbSNP
rs751764896 5 dbSNP
rs556397545 6 dbSNP
rs758731065 9 dbSNP
rs376490829 10 dbSNP
rs765726724 12 dbSNP
rs1461089071 13 dbSNP
rs759102114 20 dbSNP
rs373110866 28 dbSNP
rs1297836051 31 dbSNP
rs756967525 38 dbSNP
rs545785614 50 dbSNP
rs1174285666 51 dbSNP
rs1226068517 55 dbSNP
rs536410702 61 dbSNP
rs1040395673 69 dbSNP
rs947380695 87 dbSNP
rs1208852494 88 dbSNP
rs1287543918 91 dbSNP
rs567585341 92 dbSNP
rs1221951993 93 dbSNP
rs1317779350 93 dbSNP
rs1482008547 96 dbSNP
rs200338662 100 dbSNP
rs78279602 102 dbSNP
rs1161675087 104 dbSNP
rs1416146723 104 dbSNP
rs1491051591 104 dbSNP
rs3216111 104 dbSNP
rs397737877 104 dbSNP
rs532681988 104 dbSNP
rs1339963760 107 dbSNP
rs944198870 110 dbSNP
rs912755860 111 dbSNP
rs571665166 114 dbSNP
rs1047114141 117 dbSNP
rs930077132 118 dbSNP
rs1167499949 124 dbSNP
rs763303697 132 dbSNP
rs1243705168 151 dbSNP
rs1427587316 154 dbSNP
rs1282078482 156 dbSNP
rs955949124 159 dbSNP
rs753101613 160 dbSNP
rs1036029663 164 dbSNP
rs1386819066 171 dbSNP
rs1207194944 176 dbSNP
rs1252714613 183 dbSNP
rs981273399 184 dbSNP
rs970317867 192 dbSNP
rs1022709771 210 dbSNP
rs1443907087 211 dbSNP
rs1185438901 216 dbSNP
rs1006009940 217 dbSNP
rs1473227018 221 dbSNP
rs533826086 236 dbSNP
rs951689623 239 dbSNP
rs1432237241 241 dbSNP
rs1025946039 246 dbSNP
rs571254400 258 dbSNP
rs926551115 261 dbSNP
rs551079482 262 dbSNP
rs765644426 263 dbSNP
rs897378716 267 dbSNP
rs1294336312 268 dbSNP
rs1247404508 279 dbSNP
rs1379080839 284 dbSNP
rs1041714508 285 dbSNP
rs1444480913 288 dbSNP
rs1024831773 290 dbSNP
rs1336359189 296 dbSNP
rs1009291776 299 dbSNP
rs1275280778 305 dbSNP
rs1008379270 317 dbSNP
rs561323583 319 dbSNP
rs1198834376 321 dbSNP
rs1280789988 331 dbSNP
rs1307694691 345 dbSNP
rs1188156771 362 dbSNP
rs1408181891 365 dbSNP
rs956445486 365 dbSNP
rs749355264 366 dbSNP
rs1367269966 376 dbSNP
rs1464887361 387 dbSNP
rs1163946940 393 dbSNP
rs760114770 402 dbSNP
rs1049796330 416 dbSNP
rs1403925949 418 dbSNP
rs1469808494 424 dbSNP
rs776536843 426 dbSNP
rs1411514636 429 dbSNP
rs1160167484 432 dbSNP
rs371859105 434 dbSNP
rs1053097100 435 dbSNP
rs934676177 437 dbSNP
rs1330255594 442 dbSNP
rs1230818054 443 dbSNP
rs1231774677 456 dbSNP
rs1179592245 460 dbSNP
rs1276769409 463 dbSNP
rs1039940074 474 dbSNP
rs1208413932 475 dbSNP
rs562194986 478 dbSNP
rs1266296387 479 dbSNP
rs1466344166 479 dbSNP
rs1209865984 493 dbSNP
rs1267300003 496 dbSNP
rs1173945178 501 dbSNP
rs1431747522 512 dbSNP
rs1271594695 513 dbSNP
rs1008453955 515 dbSNP
rs780077186 518 dbSNP
rs891267259 520 dbSNP
rs1385767610 523 dbSNP
rs928551018 526 dbSNP
rs1458386089 528 dbSNP
rs1321441205 530 dbSNP
rs981792888 534 dbSNP
rs1288357805 544 dbSNP
rs1225937705 545 dbSNP
rs1351525201 548 dbSNP
rs1287786033 551 dbSNP
rs1047225234 557 dbSNP
rs930024933 558 dbSNP
rs1227988175 560 dbSNP
rs1226838951 563 dbSNP
rs1331265849 573 dbSNP
rs969872129 578 dbSNP
rs915787809 579 dbSNP
rs984625810 580 dbSNP
rs1347615258 590 dbSNP
rs1212212585 605 dbSNP
rs1268467484 610 dbSNP
rs1303597731 614 dbSNP
rs937346014 616 dbSNP
rs951741537 623 dbSNP
rs1409743691 625 dbSNP
rs866244232 626 dbSNP
rs980661674 630 dbSNP
rs1159198978 636 dbSNP
rs1367449471 649 dbSNP
rs970646276 654 dbSNP
rs756376639 656 dbSNP
rs1365923358 663 dbSNP
rs1409014874 664 dbSNP
rs1306349565 672 dbSNP
rs1352569343 676 dbSNP
rs138035008 677 dbSNP
rs1392253113 689 dbSNP
rs1312078560 690 dbSNP
rs1320239405 692 dbSNP
rs987970198 692 dbSNP
rs1293179704 697 dbSNP
rs1341836506 701 dbSNP
rs1203469302 702 dbSNP
rs956559095 703 dbSNP
rs1483828078 708 dbSNP
rs993157446 709 dbSNP
rs1177481726 711 dbSNP
rs966126332 716 dbSNP
rs1254836487 720 dbSNP
rs1421582417 732 dbSNP
rs1019855766 734 dbSNP
rs1166775884 738 dbSNP
rs1385804952 739 dbSNP
rs1428793719 740 dbSNP
rs529412654 743 dbSNP
rs560434885 751 dbSNP
rs750629409 753 dbSNP
rs540947767 762 dbSNP
rs553339884 764 dbSNP
rs1377012059 767 dbSNP
rs1397880117 768 dbSNP
rs578181736 769 dbSNP
rs12498 770 dbSNP
rs1316272878 781 dbSNP
rs370065345 783 dbSNP
rs1429578419 786 dbSNP
rs1018369371 796 dbSNP
rs73406188 803 dbSNP
rs1277191978 805 dbSNP
rs1308493160 815 dbSNP
rs1204735069 819 dbSNP
rs78816194 821 dbSNP
rs146947925 824 dbSNP
rs994289776 828 dbSNP
rs898689702 834 dbSNP
rs1448780769 835 dbSNP
rs1186650160 836 dbSNP
rs1038437242 841 dbSNP
rs937442619 844 dbSNP
rs547617313 850 dbSNP
rs1357656399 859 dbSNP
rs1467589275 862 dbSNP
rs1267660913 870 dbSNP
rs1226634689 878 dbSNP
rs1388068349 884 dbSNP
rs1045769973 890 dbSNP
rs1300494563 894 dbSNP
rs556359811 894 dbSNP
rs1219024877 896 dbSNP
rs867259110 899 dbSNP
rs893198674 902 dbSNP
rs111336306 914 dbSNP
rs1205242503 915 dbSNP
rs1263196714 915 dbSNP
rs934664786 917 dbSNP
rs925125655 927 dbSNP
rs114406492 928 dbSNP
rs573911390 932 dbSNP
rs376161105 934 dbSNP
rs915838650 946 dbSNP
rs1318398099 952 dbSNP
rs1422879354 954 dbSNP
rs1435112717 954 dbSNP
rs764531202 955 dbSNP
rs1177478337 956 dbSNP
rs1411285443 962 dbSNP
rs1470674238 965 dbSNP
rs1455734875 978 dbSNP
rs773551170 979 dbSNP
rs951880026 983 dbSNP
rs1346315250 985 dbSNP
rs1436485080 989 dbSNP
rs1292135918 990 dbSNP
rs918996621 998 dbSNP
rs972254734 1009 dbSNP
rs1283563244 1010 dbSNP
rs1431075758 1010 dbSNP
rs772487310 1013 dbSNP
rs1025840873 1020 dbSNP
rs1286176661 1022 dbSNP
rs1447507489 1023 dbSNP
rs1786111 1027 dbSNP
rs1220815608 1029 dbSNP
rs1244740150 1032 dbSNP
rs1188653872 1033 dbSNP
rs570155082 1044 dbSNP
rs779946181 1045 dbSNP
rs1017533639 1055 dbSNP
rs1161460186 1057 dbSNP
rs553671205 1060 dbSNP
rs527545569 1069 dbSNP
rs1163343258 1072 dbSNP
rs1207309798 1073 dbSNP
rs1405956266 1073 dbSNP
rs1303320738 1076 dbSNP
rs1001593155 1081 dbSNP
rs905945712 1082 dbSNP
rs1263777579 1085 dbSNP
rs1350820907 1100 dbSNP
rs1209738802 1103 dbSNP
rs1310628328 1104 dbSNP
rs534134576 1114 dbSNP
rs1028550638 1119 dbSNP
rs1287678134 1123 dbSNP
rs3180697 1127 dbSNP
rs1222965534 1130 dbSNP
rs1011681741 1131 dbSNP
rs1250889754 1135 dbSNP
rs1274931411 1135 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 114876.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aguguucacuucaUCACCCu 5'
                       |||||| 
Target 5' -------------AGUGGGa 3'
 		1 - 7
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000319481.3 | 3UTR | AGUGGGAAUAGUUUAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4301 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081134 LDLR low density lipoprotein receptor 2 4
MIRT090911 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT229436 MECP2 methyl-CpG binding protein 2 2 2
MIRT274717 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT350957 BACH1 BTB domain and CNC homolog 1 2 2
MIRT386722 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT446022 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT481303 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 14
MIRT483959 ZNF354B zinc finger protein 354B 2 6
MIRT495667 TUBAL3 tubulin alpha like 3 2 2
MIRT496554 TBX15 T-box 15 2 2
MIRT497702 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498105 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT512535 SEMA4D semaphorin 4D 2 2
MIRT512556 MFN2 mitofusin 2 2 6
MIRT521465 RABGAP1 RAB GTPase activating protein 1 2 6
MIRT526236 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526743 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527578 BRD7 bromodomain containing 7 2 4
MIRT528038 WT1 Wilms tumor 1 2 2
MIRT528267 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528505 HTR7 5-hydroxytryptamine receptor 7 2 4
MIRT528758 RPS27 ribosomal protein S27 2 6
MIRT528999 IPO9 importin 9 2 2
MIRT529701 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529781 C17orf82 chromosome 17 open reading frame 82 2 2
MIRT533797 TMEM119 transmembrane protein 119 2 6
MIRT535308 PHF12 PHD finger protein 12 2 2
MIRT535917 MKL2 MKL1/myocardin like 2 2 2
MIRT544892 OSBPL1A oxysterol binding protein like 1A 2 2
MIRT555423 PPIC peptidylprolyl isomerase C 2 2
MIRT562068 KLHL15 kelch like family member 15 2 2
MIRT565623 SLC31A1 solute carrier family 31 member 1 2 2
MIRT565661 SIX1 SIX homeobox 1 2 2
MIRT570138 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT571045 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT621232 LMAN1 lectin, mannose binding 1 2 2
MIRT622272 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623844 GAN gigaxonin 2 2
MIRT626158 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626464 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT632087 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT637243 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT642710 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT643611 KANSL3 KAT8 regulatory NSL complex subunit 3 2 2
MIRT644270 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 2 2
MIRT645470 SPIN3 spindlin family member 3 2 2
MIRT649193 DNPEP aspartyl aminopeptidase 2 2
MIRT650776 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT651345 ZC2HC1C zinc finger C2HC-type containing 1C 2 2
MIRT652237 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT652587 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654591 PURA purine rich element binding protein A 2 2
MIRT654649 PTAFR platelet activating factor receptor 2 2
MIRT656842 KLF7 Kruppel like factor 7 2 2
MIRT657209 IKZF2 IKAROS family zinc finger 2 2 2
MIRT658513 ETV3 ETS variant 3 2 2
MIRT659448 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT668816 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT669067 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT677711 ELOF1 elongation factor 1 homolog 2 4
MIRT687146 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT698498 THOC2 THO complex 2 2 2
MIRT707930 PPP1R3D protein phosphatase 1 regulatory subunit 3D 4 2
MIRT708737 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710031 POLL DNA polymerase lambda 2 2
MIRT712175 STK4 serine/threonine kinase 4 2 2
MIRT715297 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT716892 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT717378 RBM41 RNA binding motif protein 41 2 2
MIRT718082 CLIC5 chloride intracellular channel 5 2 2
MIRT718721 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT719152 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719224 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719528 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT719861 KLF2 Kruppel like factor 2 2 2
MIRT720326 CAMK2G calcium/calmodulin dependent protein kinase II gamma 2 2
MIRT721596 SREBF1 sterol regulatory element binding transcription factor 1 2 2
MIRT722020 NEBL nebulette 2 2
MIRT722484 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT722614 TEAD1 TEA domain transcription factor 1 2 2
MIRT723664 RPTN repetin 2 2
MIRT723939 SVOP SV2 related protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive High Hepatocellular Carcinoma cell line (Hep3B, 97L)
hsa-miR-4301 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4301 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4301 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4301 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-miR-4301 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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