pre-miRNA Information
pre-miRNA hsa-mir-921   
Genomic Coordinates chr1: 166154743 - 166154798
Synonyms MIRN921, hsa-mir-921, MIR921
Description Homo sapiens miR-921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-921
Sequence 2| CUAGUGAGGGACAGAACCAGGAUUC |26
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31549221 11 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1464259216 3 dbSNP
rs768428855 8 dbSNP
rs746970999 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SNRPA1   
Synonyms Lea1
Description small nuclear ribonucleoprotein polypeptide A'
Transcript NM_003090   
Expression
Putative miRNA Targets on SNRPA1
3'UTR of SNRPA1
(miRNA target sites are highlighted)
>SNRPA1|NM_003090|3'UTR
   1 GCAGTGAGGCAGATGTATAATAATAGGCCCTCTTGGAACAAGTCTTGCTTTTCGAACATGGTATAATAGCCTTGTTTGTG
  81 TTAGCAAAGTGGAATCTATCAGCATTGTTGAAATGCTTAAGACTGCTGCTGATAATTTTGTAATATAAGTTTTGAAATCT
 161 AAATGTCAATTTTCTACAAATTATAAAAATAAACTCCACTCACTATGCTACCAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuuaggaccaagacAGG-GAGUGAUc 5'
                        ||| ||||||| 
Target 5' ttataaaaataaacTCCACTCACTAt 3'
181 - 206 147.00 -10.70
2
miRNA  3' cuuAGGACCAAG-ACAGGGAGUGAuc 5'
             ||:|||  |  ||  ||::||  
Target 5' cccTCTTGGAACAAGT--CTTGCTtt 3'
28 - 51 102.00 -8.70
3
miRNA  3' cuUAGGACCAAGACA-GGGAGUGAuc 5'
            | | |||| :  |  |||:::|  
Target 5' cgAACATGGTATAATAGCCTTGTTtg 3'
53 - 78 87.00 -7.92
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32076690 12 COSMIC
COSN21442498 30 COSMIC
COSN31559673 42 COSMIC
COSN31575285 53 COSMIC
COSN31577365 54 COSMIC
COSN22483299 87 COSMIC
COSN31556718 93 COSMIC
COSN30171649 102 COSMIC
COSN30166235 150 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs532659691 4 dbSNP
rs1469427647 6 dbSNP
rs769892810 9 dbSNP
rs371225844 14 dbSNP
rs773244011 15 dbSNP
rs74041961 17 dbSNP
rs1221903615 19 dbSNP
rs748155071 24 dbSNP
rs753682647 26 dbSNP
rs1234166439 28 dbSNP
rs929315760 30 dbSNP
rs778848347 31 dbSNP
rs768377612 35 dbSNP
rs373775918 38 dbSNP
rs1390070781 41 dbSNP
rs779598461 42 dbSNP
rs755614074 43 dbSNP
rs749944550 44 dbSNP
rs1185060864 48 dbSNP
rs550279573 49 dbSNP
rs923320098 53 dbSNP
rs200311451 54 dbSNP
rs3087550 60 dbSNP
rs1172945452 65 dbSNP
rs1007252476 70 dbSNP
rs1444249564 76 dbSNP
rs1335233312 78 dbSNP
rs1361327184 82 dbSNP
rs890247130 84 dbSNP
rs1269164076 89 dbSNP
rs530761565 95 dbSNP
rs1219885659 98 dbSNP
rs1280871202 101 dbSNP
rs3087549 106 dbSNP
rs1322697117 117 dbSNP
rs563465826 125 dbSNP
rs1050845 135 dbSNP
rs1052363202 145 dbSNP
rs1017747133 146 dbSNP
rs1214812378 148 dbSNP
rs1241701425 163 dbSNP
rs1478283479 166 dbSNP
rs990325341 173 dbSNP
rs934809466 183 dbSNP
rs1427337113 185 dbSNP
rs1480391535 194 dbSNP
rs541781195 194 dbSNP
rs1173730511 195 dbSNP
rs529954943 196 dbSNP
rs1031859030 199 dbSNP
rs1318104108 204 dbSNP
rs998640938 205 dbSNP
rs1360745043 211 dbSNP
rs1401509784 215 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 6627.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cuuaggaccaagacAGG-GAGUGAUc 5'
                        ||| ||||||| 
Target 5' uuauaaaaauaaacUCCACUCACUAu 3'
16 - 41
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000254193.6 | 3UTR | UCAAUUUUCUACAAAUUAUAAAAAUAAACUCCACUCACUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38226 Liver fibrosis 0.541 5.7e-3 0.328 7.3e-2 21 Click to see details
GSE32688 Pancreatic cancer 0.437 6.2e-3 0.336 3.0e-2 32 Click to see details
GSE28544 Breast cancer 0.455 1.3e-2 0.465 1.1e-2 24 Click to see details
GSE19783 ER+ ER+ breast cancer -0.475 1.7e-2 -0.481 1.6e-2 20 Click to see details
GSE28260 Renal cortex and medulla 0.53 3.1e-2 0.330 1.4e-1 13 Click to see details
GSE17498 Multiple myeloma -0.191 1.2e-1 -0.137 2.0e-1 40 Click to see details
GSE19536 Breast cancer -0.097 1.7e-1 -0.166 4.9e-2 100 Click to see details
GSE26953 Aortic valvular endothelial cells 0.13 2.7e-1 0.179 2.0e-1 24 Click to see details
GSE21687 Ependynoma primary tumors 0.063 3.1e-1 0.001 5.0e-1 64 Click to see details
GSE19350 CNS germ cell tumors 0.127 3.5e-1 0.056 4.3e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.081 3.7e-1 -0.331 7.7e-2 20 Click to see details
GSE42095 Differentiated embryonic stem cells 0.072 3.7e-1 0.074 3.7e-1 23 Click to see details
GSE19783 ER- ER- breast cancer 0.024 4.2e-1 0.026 4.1e-1 79 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.029 4.5e-1 -0.182 1.9e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.029 4.5e-1 -0.182 1.9e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.029 4.5e-1 -0.182 1.9e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT054764 ANGPTL1 angiopoietin like 1 3 1
MIRT066171 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT069409 ZFYVE21 zinc finger FYVE-type containing 21 2 8
MIRT102284 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 4
MIRT107595 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 6
MIRT178618 HIAT1 major facilitator superfamily domain containing 14A 2 2
MIRT182407 TIPRL TOR signaling pathway regulator 2 4
MIRT186552 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT273662 HOXC8 homeobox C8 2 2
MIRT283191 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT284890 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT347670 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT400222 SLC35F6 solute carrier family 35 member F6 2 2
MIRT403517 ASPH aspartate beta-hydroxylase 2 2
MIRT442251 DCTN5 dynactin subunit 5 2 2
MIRT443023 SDR39U1 short chain dehydrogenase/reductase family 39U member 1 2 2
MIRT443097 RNF20 ring finger protein 20 2 2
MIRT444560 TRA2B transformer 2 beta homolog 2 2
MIRT445696 PRKG1 protein kinase, cGMP-dependent, type I 2 2
MIRT454084 TMEM209 transmembrane protein 209 2 2
MIRT455463 LYPLA2 lysophospholipase II 2 2
MIRT456653 TIFA TRAF interacting protein with forkhead associated domain 2 2
MIRT458147 LYRM4 LYR motif containing 4 2 6
MIRT467073 SRRD SRR1 domain containing 2 4
MIRT467245 SPPL2A signal peptide peptidase like 2A 2 2
MIRT468246 SFXN4 sideroflexin 4 2 2
MIRT471589 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT476639 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT482433 ADM adrenomedullin 2 10
MIRT486848 PERP PERP, TP53 apoptosis effector 2 6
MIRT489656 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT493441 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT493841 FOXN3 forkhead box N3 2 4
MIRT501378 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT509679 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT510280 MED28 mediator complex subunit 28 2 2
MIRT512221 ATXN3 ataxin 3 2 6
MIRT514030 BNIP2 BCL2 interacting protein 2 2 2
MIRT521375 RDX radixin 2 4
MIRT521444 RAD51 RAD51 recombinase 2 2
MIRT526055 CBR1 carbonyl reductase 1 2 2
MIRT528658 FUNDC2 FUN14 domain containing 2 2 2
MIRT529975 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT544098 IPMK inositol polyphosphate multikinase 2 2
MIRT545579 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT547424 MED4 mediator complex subunit 4 2 2
MIRT548955 CD2AP CD2 associated protein 2 2
MIRT549537 NDUFA6 NADH:ubiquinone oxidoreductase subunit A6 2 4
MIRT552550 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554640 ROBO1 roundabout guidance receptor 1 2 2
MIRT564904 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT565578 SLC6A8 solute carrier family 6 member 8 2 2
MIRT568312 BAG4 BCL2 associated athanogene 4 2 2
MIRT617891 PTCHD3 patched domain containing 3 2 2
MIRT621892 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT642850 RNF135 ring finger protein 135 2 2
MIRT665395 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT697879 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT698492 THOC2 THO complex 2 2 2
MIRT701227 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT701872 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT707045 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT715216 NPVF neuropeptide VF precursor 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-921 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miR-921 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-921 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-mir-921 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-921 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-921 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-miR-921 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-921 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-921 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-921 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-921 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-921 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-921 Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-921 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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