miRTarBase - #MIRT545752


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pre-miRNA Information
pre-miRNA hsa-mir-103b-1   
Genomic Coordinates chr5: 168560904 - 168560965
Description Homo sapiens miR-103b-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-103b-2   
Genomic Coordinates chr20: 3917502 - 3917563
Description Homo sapiens miR-103b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-103b
Sequence 1| UCAUAGCCCUGUACAAUGCUGCU |23
Evidence Experimental
Experiments ChIP-seq
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN28198041 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369221403 4 dbSNP
rs1283132774 7 dbSNP
rs1222085747 10 dbSNP
rs572980521 14 dbSNP
rs748411363 15 dbSNP
rs769854452 23 dbSNP
Putative Targets

Gene Information
Gene Symbol CA12   
Synonyms CA-XII, CAXII, HsT18816, T18816
Description carbonic anhydrase 12
Transcript NM_001218   
Other Transcripts NM_206925   
Expression
Putative miRNA Targets on CA12
3'UTR of CA12
(miRNA target sites are highlighted)		 
>CA12|NM_001218|3'UTR
   1 GGTCCCCGGAGCTCCCGGGCACATCCAGGAAGGACCTTGCTTTGGACCCTACACACTTCGGCTCTCTGGACACTTGCGAC
  81 ACCTCAAGGTGTTCTCTGTAGCTCAATCTGCAAACATGCCAGGCCTCAGGGATCCTCTGCTGGGTGCCTCCTTGCCTTGG
 161 GACCATGGCCACCCCAGAGCCATCCGATCGATGGATGGGATGCACTCTCAGACCAAGCAGCAGGAATTCAAAGCTGCTTG
 241 CTGTAACTGTGTGAGATTGTGAAGTGGTCTGAATTCTGGAATCACAAACCAAGCCATGCTGGTGGGCCATTAATGGTTGG
 321 AAAACACTTTCATCCGGGGCTTTGCCAGAGCGTGCTTTCAAGTGTCCTGGAAATTCTGCTGCTTCTCCAAGCTTTCAGAC
 401 AAGAATGTGCACTCTCTGCTTAGGTTTTGCTTGGGAAACTCAACTTCTTTCCTCTGGAGACGGGGCATCTCCCTCTGATT
 481 TCCTTCTGCTATGACAAAACCTTTAATCTGCACCTTACAACTCGGGGACAAATGGGGACAGGAAGGATCAAGTTGTAGAG
 561 AGAAAAAGAAAACAAGAGATATACATTGTGATATATTAGGGACACTTTCACAGTCCTGTCCTCTGGATCACAGACACTGC
 641 ACAGACCTTAGGGAATGGCAGGTTCAAGTTCCACTTCTTGGTGGGGATGAGAAGGGAGAGAGAGCTAGAGGGACAAAGAG
 721 AATGAGAAGACATGGATGATCTGGGAGAGTCTCACTTTGGAATCAGAATTGGAATCACATTCTGTTTATCAAGCCATAAT
 801 GTAAGGACAGAATAATACAATATTAAGTCCAAATCCAACCTCCTGTCAGTGGAGCAGTTATGTTTTATACTCTACAGATT
 881 TTACAAATAATGAGGCTGTTCCTTGAAAATGTGTTGTTGCTGTGTCCTGGAGGAGACATGAGTTCCGAGATGACCCAATC
 961 TGCCTTTGAATCTGGAGGAAATAGGCAGAAACAAAATGACTGTAGAACTTATTCTCTGTAGGCCAAATTTCATTTCAGCC
1041 ACTTCTGCAGGATCCCTACTGCCAACCTGGAATGGAGACTTTTATCTACTTCTCTCTCTCTGAAGATGTCAAATCGTGGT
1121 TTAGATCAAATATATTTCAAGCTATAAAAGCAGGAGGTTATCTGTGCAGGGGGCTGGCATCATGTATTTAGGGGCAAGTA
1201 ATAATGGAATGCTACTAAGATACTCCATATTCTTCCCCGAATCACACAGACAGTTTCTGACAGGCGCAACTCCTCCATTT
1281 TCCTCCCGCAGGTGAGAACCCTGTGGAGATGAGTCAGTGCCATGACTGAGAAGGAACCGACCCCTAGTTGAGAGCACCTT
1361 GCAGTTCCCCGAGAACTTTCTGATTCACAGTCTCATTTTGACAGCATGAAATGTCCTCTTGAAGCATAGCTTTTTAAATA
1441 TCTTTTTCCTTCTACTCCTCCCTCTGACTCTAAGAATTCTCTCTTCTGGAATCGCTTGAACCCAGGAGGCGGAGGTTGCA
1521 GTAAGCCAAGGTCATGCCACTGCACTCTAGCCTGGGTGACAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAAAATTA
1601 TTCTGTACCATCACAACTTTTCACAACGATGGCAAGCCTTATGTCTTGGGAGCCTGTTTTGCTAGGCAAAGTTACAAGTG
1681 ACCTAATGGGAGCTCAAATGTGTGTGTGTCTCTCTGTGTGTTTGTGTGTGTGTGTGCACTCAAGACCTCTAACAGCCTCG
1761 AAGCCTGGGGTGGCATCCCGGCCTTGCCATTAGCATGCCTCATGCATCATCAGATGACAAGGACAACCCTCATGACGAAG
1841 CAACATGAATTAGGGGGCCTCTTGGCCTTGGTCCAAAATTGTCAATCAGAAATGAACATAAAGGACTCCAGAGCAGTGGG
1921 ACTGTCTGTCAAAAGACTCTGTATATCTTTTGTGGATGAGTTTTGTGAGAGAACAGAGAGACCATTGTACCTGGCACAAG
2001 GGCTGTTCATGAAAAGGGAGACTTACTGGGAGGTGCAAGACAGTGGCATTTCTCCTCTCCTCTTGCTGCTCAGCACAGCC
2081 CTGGATTGCAGCCCCGAGGCTGAGACCAGACAAAGCCCGGGAGGCAGAAAGATGCTCCAAGAACCAACACTATCAATGTC
2161 TTTGCAAATCCTCACAGGATTCCTGTGGGTCCAGCTTTGGAACTGGGAAACCTTTCTTCGGATCCGCACTCATTCCACTG
2241 ATGCCAGCTGCCCCTGAAGGATGCCAGTACTGTGGTGTGTGAGTCTCAGCAGCCGCCCACACGCTCCTAACTCTGCTGCA
2321 TGGCAGATGCCTAGGTGGAAATAGCAAAAACAAGGCCCAGGCTGGGGCCAGGGCCAGAGGGGAAGGCCCTGGATTCTCAC
2401 TCATGTGAGATCTTGAATCTCTTTCTTTGTTCTGTTTGTTTAGTTAGTATCATCTGGTAAAATAGTTAAAAAACAACAAA
2481 AAACTCTGTATCTGTTTCTAGCATGTGCTGCATTGACTCTATTAATCACATTTCAAATTCACCCTACATTCCTCTCCTCT
2561 TCACTAGCCTCTCTGAAGGTGTCCTGGCCAGCCCTGGAGAAGCACTGGTGTCTGCAGCACCCCTCAGTTCCTGTGCCTCA
2641 GCCCACAGGCCACTGTGATAATGGTCTGTTTAGCACTTCTGTATTTATTGTAAGAATGATTATAATGAAGATACACACTG
2721 TAACTACAAGAAATTATAAATGTTTTTCACATCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucgUCGUAACAUG--------UCCCGAUAcu 5'
             | ||||||||        ||||||:|  
Target 5' gagACCATTGTACCTGGCACAAGGGCTGTtc 3'
 1978 - 2008 134.00 -18.00
2 
miRNA  3' ucGUCGUAACAUGUCCCGAUACu 5'
            || : |  | |:||||| || 
Target 5' aaCACTTTCATCCGGGGCTTTGc 3'
 323 - 345 125.00 -12.10
3 
miRNA  3' ucGUCGUAACAUGU------C-CCGAUAcu 5'
            ||| ||| ||||      | ||||:|  
Target 5' taCAG-ATTTTACAAATAATGAGGCTGTtc 3'
 873 - 901 122.00 -9.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24313681 4 COSMIC
COSN31544908 7 COSMIC
COSN23295459 14 COSMIC
COSN31508998 16 COSMIC
COSN7050701 17 COSMIC
COSN30466632 20 COSMIC
COSN30466625 22 COSMIC
COSN30478017 29 COSMIC
COSN30485284 33 COSMIC
COSN20078273 51 COSMIC
COSN31581897 77 COSMIC
COSN31611520 78 COSMIC
COSN30171584 83 COSMIC
COSN26097871 106 COSMIC
COSN31533686 118 COSMIC
COSN1681963 190 COSMIC
COSN1681962 333 COSMIC
COSN24052029 463 COSMIC
COSN32091791 686 COSMIC
COSN20092982 784 COSMIC
COSN26151788 1479 COSMIC
COSN16991978 1525 COSMIC
COSN1178807 1578 COSMIC
COSN20112159 1578 COSMIC
COSN6544721 1646 COSMIC
COSN20625978 1894 COSMIC
COSN30543343 2591 COSMIC
COSN31530492 2730 COSMIC
COSN29326224 2993 COSMIC
COSN18860287 3114 COSMIC
COSN5213442 3433 COSMIC
COSN16349486 3911 COSMIC
COSN1681961 3947 COSMIC
COSN25196000 4367 COSMIC
COSN5399709 4453 COSMIC
COSN24271517 4541 COSMIC
COSN24273155 4579 COSMIC
COSN8175627 4582 COSMIC
COSN6544720 4626 COSMIC
COSN19072636 4668 COSMIC
COSN22632836 4814 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763880884 4 dbSNP
rs752504605 7 dbSNP
rs1190458891 8 dbSNP
rs191277004 15 dbSNP
rs373274369 16 dbSNP
rs371148738 17 dbSNP
rs771165950 18 dbSNP
rs188698859 19 dbSNP
rs1349567288 20 dbSNP
rs773387934 22 dbSNP
rs373222464 23 dbSNP
rs1444181220 25 dbSNP
rs1163842426 28 dbSNP
rs770449156 35 dbSNP
rs748604832 44 dbSNP
rs1440908866 47 dbSNP
rs777055398 49 dbSNP
rs1366429057 50 dbSNP
rs184637942 59 dbSNP
rs193170550 60 dbSNP
rs1399456165 64 dbSNP
rs1443992796 77 dbSNP
rs188320023 77 dbSNP
rs149272619 78 dbSNP
rs1181229138 79 dbSNP
rs117090742 82 dbSNP
rs1392371275 83 dbSNP
rs1047296457 89 dbSNP
rs1039121972 90 dbSNP
rs111662990 91 dbSNP
rs1245980590 95 dbSNP
rs1251281330 101 dbSNP
rs1316569286 103 dbSNP
rs3842343 103 dbSNP
rs1466584201 104 dbSNP
rs1402960383 107 dbSNP
rs535563753 116 dbSNP
rs1168935448 117 dbSNP
rs1427576990 126 dbSNP
rs868642669 131 dbSNP
rs1258519115 139 dbSNP
rs888028360 142 dbSNP
rs1047973386 146 dbSNP
rs747362208 155 dbSNP
rs1400309621 157 dbSNP
rs1465247627 158 dbSNP
rs929496953 161 dbSNP
rs928792278 181 dbSNP
rs1425361639 185 dbSNP
rs1038835597 186 dbSNP
rs1339130135 189 dbSNP
rs1220926200 190 dbSNP
rs1258808560 191 dbSNP
rs948090491 199 dbSNP
rs547104668 209 dbSNP
rs1476791815 213 dbSNP
rs1258030884 218 dbSNP
rs1251819682 222 dbSNP
rs374714166 229 dbSNP
rs1459009352 230 dbSNP
rs11556746 234 dbSNP
rs948823235 236 dbSNP
rs939310583 241 dbSNP
rs549787566 243 dbSNP
rs772389347 249 dbSNP
rs537438834 257 dbSNP
rs1432131508 258 dbSNP
rs1173312231 264 dbSNP
rs915968368 265 dbSNP
rs977902439 267 dbSNP
rs1467956125 270 dbSNP
rs570416262 284 dbSNP
rs1302326673 294 dbSNP
rs748715948 299 dbSNP
rs1279462240 301 dbSNP
rs184166337 302 dbSNP
rs1303441297 304 dbSNP
rs957356730 310 dbSNP
rs1313032390 317 dbSNP
rs1216081232 319 dbSNP
rs1022058112 326 dbSNP
rs1032715256 331 dbSNP
rs978027325 332 dbSNP
rs11556747 334 dbSNP
rs966563593 335 dbSNP
rs1448212410 336 dbSNP
rs1018662446 340 dbSNP
rs1433421054 344 dbSNP
rs773674696 344 dbSNP
rs779342366 344 dbSNP
rs1378089983 346 dbSNP
rs527549738 351 dbSNP
rs997328419 352 dbSNP
rs900259068 354 dbSNP
rs1025865554 357 dbSNP
rs1017314420 360 dbSNP
rs1434896211 362 dbSNP
rs1461736839 369 dbSNP
rs1043239 374 dbSNP
rs548385158 379 dbSNP
rs138250348 387 dbSNP
rs1307434885 400 dbSNP
rs1038520766 405 dbSNP
rs1242077725 411 dbSNP
rs1393997261 418 dbSNP
rs562834830 423 dbSNP
rs368202153 427 dbSNP
rs929539025 439 dbSNP
rs192451686 442 dbSNP
rs895231030 444 dbSNP
rs577174187 449 dbSNP
rs11556745 452 dbSNP
rs187562765 461 dbSNP
rs915985572 462 dbSNP
rs939320638 471 dbSNP
rs1441110447 491 dbSNP
rs1257521028 492 dbSNP
rs1190252019 493 dbSNP
rs759764520 497 dbSNP
rs780812108 500 dbSNP
rs1159666110 507 dbSNP
rs1413440157 508 dbSNP
rs573177698 515 dbSNP
rs923862545 518 dbSNP
rs751709374 523 dbSNP
rs936034155 548 dbSNP
rs1350972739 562 dbSNP
rs1446193320 576 dbSNP
rs761975217 576 dbSNP
rs1379433932 578 dbSNP
rs1447711275 583 dbSNP
rs1240889539 584 dbSNP
rs1279934128 586 dbSNP
rs924622959 595 dbSNP
rs182213169 596 dbSNP
rs1291986225 599 dbSNP
rs1335370756 605 dbSNP
rs1356468171 611 dbSNP
rs1458820768 624 dbSNP
rs974600956 638 dbSNP
rs978438820 647 dbSNP
rs1472053922 653 dbSNP
rs1305573993 654 dbSNP
rs1415183710 660 dbSNP
rs1337263778 663 dbSNP
rs1266979019 666 dbSNP
rs764099194 687 dbSNP
rs1380410961 688 dbSNP
rs1168629684 689 dbSNP
rs966636818 695 dbSNP
rs150453767 702 dbSNP
rs1333832732 703 dbSNP
rs1338890808 705 dbSNP
rs911611563 708 dbSNP
rs564950567 712 dbSNP
rs555988411 720 dbSNP
rs140689493 732 dbSNP
rs950341478 734 dbSNP
rs751289793 746 dbSNP
rs1017806249 751 dbSNP
rs994853713 752 dbSNP
rs1277528411 753 dbSNP
rs1043240 755 dbSNP
rs1005954731 756 dbSNP
rs1158359512 764 dbSNP
rs962972849 769 dbSNP
rs1424298927 771 dbSNP
rs1258574650 772 dbSNP
rs1477788351 784 dbSNP
rs899544914 784 dbSNP
rs1185472463 787 dbSNP
rs1245891504 789 dbSNP
rs199524043 790 dbSNP
rs951824708 794 dbSNP
rs376180374 798 dbSNP
rs1356014007 803 dbSNP
rs1259012738 807 dbSNP
rs1239007355 809 dbSNP
rs1172044979 815 dbSNP
rs1322806157 819 dbSNP
rs1400366844 826 dbSNP
rs758220744 830 dbSNP
rs993093483 842 dbSNP
rs1012408266 845 dbSNP
rs552176596 847 dbSNP
rs534111892 861 dbSNP
rs1276303396 864 dbSNP
rs544977503 874 dbSNP
rs1227583266 902 dbSNP
rs1273686995 909 dbSNP
rs752657623 910 dbSNP
rs1056434735 913 dbSNP
rs1045924549 920 dbSNP
rs902551809 922 dbSNP
rs1042373825 923 dbSNP
rs562720145 926 dbSNP
rs566758885 936 dbSNP
rs1013080222 938 dbSNP
rs894638028 942 dbSNP
rs1298493968 945 dbSNP
rs1401439332 947 dbSNP
rs1054976672 950 dbSNP
rs1375937267 953 dbSNP
rs1479139078 954 dbSNP
rs548408208 956 dbSNP
rs1287745583 958 dbSNP
rs1174561368 961 dbSNP
rs1458370150 967 dbSNP
rs1370063831 973 dbSNP
rs1296094489 986 dbSNP
rs1162530668 996 dbSNP
rs936082393 1005 dbSNP
rs1474795150 1009 dbSNP
rs915155584 1012 dbSNP
rs1194710341 1019 dbSNP
rs1039288884 1021 dbSNP
rs1259780806 1022 dbSNP
rs943146192 1034 dbSNP
rs1303740062 1040 dbSNP
rs1204578920 1047 dbSNP
rs1489100254 1051 dbSNP
rs1352495535 1060 dbSNP
rs1238457169 1070 dbSNP
rs1352041950 1080 dbSNP
rs924667599 1084 dbSNP
rs529848296 1090 dbSNP
rs562659479 1092 dbSNP
rs1201992396 1095 dbSNP
rs73447435 1096 dbSNP
rs987192057 1102 dbSNP
rs765126185 1110 dbSNP
rs372177483 1115 dbSNP
rs918947065 1116 dbSNP
rs1438011341 1118 dbSNP
rs532439512 1123 dbSNP
rs565211549 1124 dbSNP
rs1365264139 1141 dbSNP
rs759683302 1145 dbSNP
rs1454106419 1167 dbSNP
rs923222611 1175 dbSNP
rs963323484 1176 dbSNP
rs975988879 1179 dbSNP
rs1388447730 1191 dbSNP
rs991398741 1195 dbSNP
rs1220127213 1209 dbSNP
rs3922921 1225 dbSNP
rs146871893 1227 dbSNP
rs1375735781 1236 dbSNP
rs1444037058 1238 dbSNP
rs910365343 1239 dbSNP
rs774485193 1254 dbSNP
rs1336785029 1259 dbSNP
rs1386784568 1264 dbSNP
rs77227433 1265 dbSNP
rs560951516 1266 dbSNP
rs766647945 1273 dbSNP
rs1323872179 1282 dbSNP
rs1026450600 1288 dbSNP
rs1400812297 1291 dbSNP
rs760978739 1292 dbSNP
rs1802148 1293 dbSNP
rs1419496122 1299 dbSNP
rs112525680 1300 dbSNP
rs773404900 1302 dbSNP
rs1366666975 1305 dbSNP
rs575639602 1306 dbSNP
rs893719423 1309 dbSNP
rs1165017896 1317 dbSNP
rs1398849570 1320 dbSNP
rs1463594462 1321 dbSNP
rs772464046 1330 dbSNP
rs762128663 1338 dbSNP
rs557462650 1339 dbSNP
rs943679734 1341 dbSNP
rs1038929290 1352 dbSNP
rs1054648853 1353 dbSNP
rs1000743799 1359 dbSNP
rs186611808 1361 dbSNP
rs1316209911 1367 dbSNP
rs577131693 1370 dbSNP
rs1252156538 1371 dbSNP
rs1041820434 1376 dbSNP
rs1199692926 1382 dbSNP
rs1253733867 1390 dbSNP
rs934013920 1398 dbSNP
rs1188645213 1414 dbSNP
rs1422826052 1415 dbSNP
rs1476580376 1416 dbSNP
rs1171881714 1423 dbSNP
rs1259140521 1426 dbSNP
rs377708774 1430 dbSNP
rs1301470733 1431 dbSNP
rs1377706638 1442 dbSNP
rs941664880 1444 dbSNP
rs1298158387 1449 dbSNP
rs1339060525 1457 dbSNP
rs1216423667 1458 dbSNP
rs910143576 1461 dbSNP
rs774497250 1472 dbSNP
rs1257971975 1489 dbSNP
rs1486568760 1493 dbSNP
rs867840312 1493 dbSNP
rs558855203 1494 dbSNP
rs534087848 1506 dbSNP
rs1035190593 1507 dbSNP
rs1233500878 1510 dbSNP
rs910429734 1511 dbSNP
rs984646445 1515 dbSNP
rs1432077218 1521 dbSNP
rs1173597777 1530 dbSNP
rs1396473879 1533 dbSNP
rs1435778745 1554 dbSNP
rs951934294 1565 dbSNP
rs773817826 1566 dbSNP
rs1433418808 1570 dbSNP
rs1242439932 1576 dbSNP
rs1300582404 1577 dbSNP
rs1377695984 1577 dbSNP
rs1331313452 1578 dbSNP
rs763925336 1578 dbSNP
rs769580808 1578 dbSNP
rs3056733 1579 dbSNP
rs78322638 1579 dbSNP
rs982239115 1586 dbSNP
rs1195242464 1598 dbSNP
rs1305948208 1598 dbSNP
rs746508810 1598 dbSNP
rs878864381 1598 dbSNP
rs971782708 1598 dbSNP
rs1377486662 1599 dbSNP
rs966775331 1599 dbSNP
rs1158421701 1605 dbSNP
rs971068706 1607 dbSNP
rs1023907418 1612 dbSNP
rs1402795477 1615 dbSNP
rs1333133979 1627 dbSNP
rs1407934698 1629 dbSNP
rs1456499337 1631 dbSNP
rs1021000877 1635 dbSNP
rs1372045158 1645 dbSNP
rs1446237336 1649 dbSNP
rs1011345599 1652 dbSNP
rs1370991097 1653 dbSNP
rs566426138 1662 dbSNP
rs1466716783 1665 dbSNP
rs991091891 1669 dbSNP
rs1211313158 1689 dbSNP
rs1274431628 1691 dbSNP
rs959000335 1692 dbSNP
rs1033646614 1693 dbSNP
rs1191778738 1697 dbSNP
rs1468651662 1700 dbSNP
rs1177686142 1710 dbSNP
rs554261389 1710 dbSNP
rs1235975046 1712 dbSNP
rs1178119662 1714 dbSNP
rs1413736672 1716 dbSNP
rs1422545149 1716 dbSNP
rs1532570 1725 dbSNP
rs1000406887 1729 dbSNP
rs903341321 1730 dbSNP
rs1018011802 1731 dbSNP
rs574871776 1733 dbSNP
rs145504575 1737 dbSNP
rs752391687 1737 dbSNP
rs758873357 1737 dbSNP
rs890373440 1737 dbSNP
rs1444134215 1738 dbSNP
rs1279879222 1740 dbSNP
rs1051629454 1741 dbSNP
rs536281799 1744 dbSNP
rs998252191 1746 dbSNP
rs1334992843 1753 dbSNP
rs145180578 1756 dbSNP
rs550674677 1759 dbSNP
rs1037431167 1779 dbSNP
rs1205702364 1780 dbSNP
rs1237200155 1783 dbSNP
rs941704275 1798 dbSNP
rs1419170489 1802 dbSNP
rs116783905 1811 dbSNP
rs1168558518 1822 dbSNP
rs879798825 1829 dbSNP
rs374969132 1836 dbSNP
rs1358419774 1847 dbSNP
rs571518108 1865 dbSNP
rs889040066 1887 dbSNP
rs1314703183 1902 dbSNP
rs1355989804 1903 dbSNP
rs769212482 1906 dbSNP
rs924297340 1911 dbSNP
rs546843694 1915 dbSNP
rs1311456950 1916 dbSNP
rs1214738765 1917 dbSNP
rs1439906444 1918 dbSNP
rs61732378 1923 dbSNP
rs1213436173 1924 dbSNP
rs1258850308 1935 dbSNP
rs919080489 1937 dbSNP
rs966882080 1941 dbSNP
rs1243859396 1943 dbSNP
rs971810806 1965 dbSNP
rs182911393 1970 dbSNP
rs777159143 1976 dbSNP
rs989611423 1977 dbSNP
rs958342374 1984 dbSNP
rs1017641840 1985 dbSNP
rs954617092 1991 dbSNP
rs1171858138 1994 dbSNP
rs1315633415 1995 dbSNP
rs916968796 2000 dbSNP
rs1327743647 2002 dbSNP
rs1043256 2005 dbSNP
rs1345230093 2009 dbSNP
rs530962255 2020 dbSNP
rs993348850 2026 dbSNP
rs1281406955 2028 dbSNP
rs1353637394 2034 dbSNP
rs958611408 2036 dbSNP
rs1380982940 2038 dbSNP
rs1160848708 2040 dbSNP
rs1033299911 2042 dbSNP
rs1198224412 2044 dbSNP
rs1232692676 2057 dbSNP
rs1037925909 2061 dbSNP
rs1455716309 2073 dbSNP
rs1195272902 2087 dbSNP
rs1395398725 2089 dbSNP
rs979409024 2095 dbSNP
rs1188618292 2096 dbSNP
rs563602703 2115 dbSNP
rs1006008851 2116 dbSNP
rs967593647 2118 dbSNP
rs545497750 2119 dbSNP
rs1368336688 2120 dbSNP
rs1442577283 2122 dbSNP
rs1303671880 2134 dbSNP
rs577071015 2135 dbSNP
rs1237294741 2142 dbSNP
rs1055396072 2150 dbSNP
rs998325617 2152 dbSNP
rs901264787 2155 dbSNP
rs376620267 2156 dbSNP
rs1401943441 2157 dbSNP
rs1470006315 2163 dbSNP
rs1046605485 2167 dbSNP
rs1006932397 2171 dbSNP
rs888437763 2180 dbSNP
rs1285712286 2181 dbSNP
rs141181748 2203 dbSNP
rs1470431672 2211 dbSNP
rs1163595216 2212 dbSNP
rs1391720253 2216 dbSNP
rs779573782 2219 dbSNP
rs540476617 2220 dbSNP
rs573162859 2225 dbSNP
rs1036168473 2226 dbSNP
rs958180729 2227 dbSNP
rs552517274 2228 dbSNP
rs535846255 2238 dbSNP
rs1311357223 2239 dbSNP
rs61731239 2240 dbSNP
rs1361289349 2244 dbSNP
rs917001278 2252 dbSNP
rs991637108 2259 dbSNP
rs1337134969 2263 dbSNP
rs914509820 2292 dbSNP
rs151042053 2294 dbSNP
rs1479755304 2295 dbSNP
rs1407818452 2300 dbSNP
rs1030265826 2302 dbSNP
rs1476429784 2303 dbSNP
rs993457654 2304 dbSNP
rs1416124496 2305 dbSNP
rs1475930236 2309 dbSNP
rs925588485 2314 dbSNP
rs1372178833 2315 dbSNP
rs1460095000 2325 dbSNP
rs978425279 2329 dbSNP
rs1300281695 2330 dbSNP
rs1397735274 2337 dbSNP
rs1477920810 2341 dbSNP
rs967635616 2342 dbSNP
rs1016132495 2350 dbSNP
rs1006434331 2352 dbSNP
rs1277569359 2358 dbSNP
rs1212969126 2360 dbSNP
rs1229960241 2362 dbSNP
rs894229110 2365 dbSNP
rs1339875486 2367 dbSNP
rs142844666 2369 dbSNP
rs1055447556 2372 dbSNP
rs571056494 2379 dbSNP
rs1188052147 2380 dbSNP
rs1260366038 2387 dbSNP
rs976920645 2393 dbSNP
rs868449978 2396 dbSNP
rs906908527 2398 dbSNP
rs1172175720 2401 dbSNP
rs1373259671 2404 dbSNP
rs1215474650 2407 dbSNP
rs1332473358 2409 dbSNP
rs1172116895 2412 dbSNP
rs1377800170 2416 dbSNP
rs965531783 2422 dbSNP
rs546782011 2427 dbSNP
rs1360036531 2428 dbSNP
rs1383964353 2429 dbSNP
rs1018394705 2438 dbSNP
rs148536072 2449 dbSNP
rs952767066 2454 dbSNP
rs1027421806 2456 dbSNP
rs752499669 2461 dbSNP
rs567841112 2463 dbSNP
rs78945440 2468 dbSNP
rs910659072 2477 dbSNP
rs1211584074 2481 dbSNP
rs1260073479 2482 dbSNP
rs1327230331 2484 dbSNP
rs897756903 2487 dbSNP
rs1036199528 2488 dbSNP
rs1463448149 2488 dbSNP
rs750892640 2490 dbSNP
rs1014074719 2494 dbSNP
rs1192157642 2494 dbSNP
rs1397333260 2498 dbSNP
rs530776281 2501 dbSNP
rs1159065485 2502 dbSNP
rs972466568 2503 dbSNP
rs1164601843 2516 dbSNP
rs1477951624 2518 dbSNP
rs1055570145 2541 dbSNP
rs1370539176 2543 dbSNP
rs373216656 2546 dbSNP
rs1184403447 2547 dbSNP
rs1219559030 2548 dbSNP
rs563708291 2549 dbSNP
rs1016554915 2551 dbSNP
rs186736396 2556 dbSNP
rs984657726 2559 dbSNP
rs144403934 2572 dbSNP
rs1034131163 2582 dbSNP
rs1195463424 2588 dbSNP
rs375848932 2592 dbSNP
rs945655028 2595 dbSNP
rs545094971 2596 dbSNP
rs906956110 2597 dbSNP
rs1176934855 2607 dbSNP
rs1272339345 2614 dbSNP
rs182572128 2621 dbSNP
rs767795791 2624 dbSNP
rs1406463122 2634 dbSNP
rs1421330141 2691 dbSNP
rs1198976255 2698 dbSNP
rs540409933 2715 dbSNP
rs1459939721 2717 dbSNP
rs77882042 2717 dbSNP
rs965565995 2718 dbSNP
rs1127203 2720 dbSNP
rs191079071 2723 dbSNP
rs766592780 2727 dbSNP
rs1225447375 2732 dbSNP
rs952922327 2733 dbSNP
rs1333567406 2742 dbSNP
rs1027039380 2756 dbSNP
rs773917413 2762 dbSNP
rs1451778888 2765 dbSNP
rs889317690 2768 dbSNP
rs76346897 2775 dbSNP
rs1178356182 2776 dbSNP
rs1181396254 2776 dbSNP
rs1417738699 2776 dbSNP
rs369693320 2776 dbSNP
rs1443784507 2781 dbSNP
rs1167136490 2784 dbSNP
rs575085753 2795 dbSNP
rs1369354709 2803 dbSNP
rs34704344 2813 dbSNP
rs1352611185 2815 dbSNP
rs961358256 2819 dbSNP
rs933425925 2827 dbSNP
rs547333266 2828 dbSNP
rs1308609144 2855 dbSNP
rs1014821238 2857 dbSNP
rs1014105777 2865 dbSNP
rs538288065 2866 dbSNP
rs577303688 2874 dbSNP
rs1270443727 2878 dbSNP
rs1367554483 2885 dbSNP
rs552677795 2889 dbSNP
rs750631765 2893 dbSNP
rs767702537 2903 dbSNP
rs534860198 2907 dbSNP
rs1190164134 2913 dbSNP
rs1238179060 2915 dbSNP
rs1475121427 2916 dbSNP
rs1042808677 2917 dbSNP
rs940662817 2918 dbSNP
rs531097306 2926 dbSNP
rs1421884371 2932 dbSNP
rs1252224324 2949 dbSNP
rs533562969 2950 dbSNP
rs1168946278 2951 dbSNP
rs1179174138 2953 dbSNP
rs985139502 2955 dbSNP
rs1314632186 2956 dbSNP
rs1340625126 2963 dbSNP
rs945727246 2964 dbSNP
rs958595366 2965 dbSNP
rs1363578876 2966 dbSNP
rs1229649704 2972 dbSNP
rs1279979709 2976 dbSNP
rs762227382 2990 dbSNP
rs1034183416 2998 dbSNP
rs1041344324 3005 dbSNP
rs1213722005 3010 dbSNP
rs944289980 3013 dbSNP
rs1446547032 3014 dbSNP
rs911452047 3015 dbSNP
rs1450251692 3019 dbSNP
rs986042826 3028 dbSNP
rs1188988279 3029 dbSNP
rs1394314410 3030 dbSNP
rs567863061 3031 dbSNP
rs567420860 3034 dbSNP
rs186295568 3046 dbSNP
rs1174288556 3048 dbSNP
rs1345815434 3066 dbSNP
rs1402797555 3077 dbSNP
rs1399641011 3084 dbSNP
rs1303395560 3087 dbSNP
rs1020416587 3088 dbSNP
rs866272494 3093 dbSNP
rs1376040182 3105 dbSNP
rs1369288707 3110 dbSNP
rs1236922222 3114 dbSNP
rs180957851 3117 dbSNP
rs972776878 3124 dbSNP
rs570298319 3125 dbSNP
rs1032666669 3127 dbSNP
rs1296767914 3132 dbSNP
rs1465391652 3135 dbSNP
rs961380766 3147 dbSNP
rs1251341122 3168 dbSNP
rs1452398592 3178 dbSNP
rs1001141628 3190 dbSNP
rs551787964 3198 dbSNP
rs1050591041 3208 dbSNP
rs997644768 3219 dbSNP
rs1413612355 3221 dbSNP
rs1457278020 3222 dbSNP
rs992088856 3223 dbSNP
rs1324857029 3229 dbSNP
rs867601316 3232 dbSNP
rs901945385 3235 dbSNP
rs140545934 3239 dbSNP
rs1034231301 3248 dbSNP
rs1281778254 3257 dbSNP
rs1330000578 3265 dbSNP
rs1001813149 3277 dbSNP
rs559860135 3278 dbSNP
rs1232735622 3279 dbSNP
rs1271521409 3281 dbSNP
rs904346935 3287 dbSNP
rs1176354604 3288 dbSNP
rs1021414541 3290 dbSNP
rs1267724392 3294 dbSNP
rs1436989007 3296 dbSNP
rs774595337 3302 dbSNP
rs891528369 3303 dbSNP
rs1040746823 3308 dbSNP
rs943653601 3323 dbSNP
rs1163499354 3326 dbSNP
rs890038617 3345 dbSNP
rs1392101 3347 dbSNP
rs1163457449 3352 dbSNP
rs931509041 3359 dbSNP
rs1390025321 3361 dbSNP
rs188153592 3363 dbSNP
rs147210615 3366 dbSNP
rs143755361 3371 dbSNP
rs981245818 3376 dbSNP
rs1337248243 3380 dbSNP
rs1245858148 3384 dbSNP
rs940120083 3389 dbSNP
rs1338576397 3391 dbSNP
rs1356499242 3392 dbSNP
rs1193803591 3395 dbSNP
rs1253896688 3396 dbSNP
rs1483320301 3399 dbSNP
rs1186633416 3400 dbSNP
rs1254841757 3411 dbSNP
rs34041303 3413 dbSNP
rs1425009192 3420 dbSNP
rs139407493 3425 dbSNP
rs1412513629 3432 dbSNP
rs992123051 3435 dbSNP
rs563277931 3445 dbSNP
rs1288893455 3447 dbSNP
rs1170800415 3460 dbSNP
rs72748930 3461 dbSNP
rs1311566618 3462 dbSNP
rs577239918 3466 dbSNP
rs1381477887 3467 dbSNP
rs12902541 3468 dbSNP
rs1158288164 3476 dbSNP
rs980028773 3496 dbSNP
rs1225012061 3504 dbSNP
rs1276452026 3505 dbSNP
rs1342581027 3506 dbSNP
rs1475447826 3508 dbSNP
rs968981579 3514 dbSNP
rs1419738476 3516 dbSNP
rs1190387009 3519 dbSNP
rs1278094627 3520 dbSNP
rs1033131462 3521 dbSNP
rs1181876797 3527 dbSNP
rs1260615932 3534 dbSNP
rs1426323954 3534 dbSNP
rs375380692 3540 dbSNP
rs371532116 3542 dbSNP
rs1454081484 3546 dbSNP
rs879899111 3549 dbSNP
rs1361351172 3551 dbSNP
rs150721648 3553 dbSNP
rs1205727322 3554 dbSNP
rs28516020 3555 dbSNP
rs1259550258 3559 dbSNP
rs1298569421 3567 dbSNP
rs1233275814 3572 dbSNP
rs1019336950 3573 dbSNP
rs1008350201 3583 dbSNP
rs1313815724 3585 dbSNP
rs889452022 3596 dbSNP
rs1259577868 3603 dbSNP
rs570311118 3612 dbSNP
rs931598720 3619 dbSNP
rs1210249707 3628 dbSNP
rs552127829 3641 dbSNP
rs185021520 3648 dbSNP
rs746539990 3652 dbSNP
rs1468333209 3654 dbSNP
rs1192072647 3660 dbSNP
rs1036511753 3664 dbSNP
rs1434214772 3667 dbSNP
rs777477318 3669 dbSNP
rs940152874 3673 dbSNP
rs1458884955 3683 dbSNP
rs566091284 3690 dbSNP
rs1295466113 3692 dbSNP
rs1393947800 3693 dbSNP
rs918041002 3698 dbSNP
rs551621975 3699 dbSNP
rs1291532936 3701 dbSNP
rs1295680293 3702 dbSNP
rs1219788800 3710 dbSNP
rs1306160422 3712 dbSNP
rs75240750 3713 dbSNP
rs1359241411 3714 dbSNP
rs1229679480 3715 dbSNP
rs1268379421 3719 dbSNP
rs927233931 3721 dbSNP
rs771678380 3728 dbSNP
rs1045597301 3733 dbSNP
rs1248871741 3740 dbSNP
rs1488994891 3742 dbSNP
rs1461869778 3752 dbSNP
rs949958684 3758 dbSNP
rs1177201992 3769 dbSNP
rs913080794 3779 dbSNP
rs1473621280 3783 dbSNP
rs988659757 3796 dbSNP
rs1162462996 3797 dbSNP
rs926626811 3800 dbSNP
rs1460026874 3801 dbSNP
rs141172863 3806 dbSNP
rs562083405 3808 dbSNP
rs1194159274 3816 dbSNP
rs549145808 3830 dbSNP
rs1297595109 3833 dbSNP
rs1259716155 3844 dbSNP
rs1411162867 3846 dbSNP
rs34816444 3848 dbSNP
rs1188530298 3849 dbSNP
rs747916031 3850 dbSNP
rs1333502304 3851 dbSNP
rs1226298462 3855 dbSNP
rs1469272172 3858 dbSNP
rs1275455842 3861 dbSNP
rs1212138637 3862 dbSNP
rs1334608413 3863 dbSNP
rs868387994 3869 dbSNP
rs1251590704 3870 dbSNP
rs1229132140 3871 dbSNP
rs1204196647 3872 dbSNP
rs1273112076 3874 dbSNP
rs1484299565 3878 dbSNP
rs914458201 3882 dbSNP
rs1294189449 3883 dbSNP
rs1163474772 3885 dbSNP
rs75308895 3885 dbSNP
rs768761402 3885 dbSNP
rs1279731163 3886 dbSNP
rs200906832 3887 dbSNP
rs1431607311 3890 dbSNP
rs988647651 3892 dbSNP
rs1029319105 3903 dbSNP
rs997789779 3903 dbSNP
rs1373014591 3904 dbSNP
rs1379358299 3909 dbSNP
rs552652921 3909 dbSNP
rs1214382336 3913 dbSNP
rs1439978025 3937 dbSNP
rs1344727186 3939 dbSNP
rs754922293 3941 dbSNP
rs1019410813 3948 dbSNP
rs1396924017 3951 dbSNP
rs1206548395 3952 dbSNP
rs1280236359 3954 dbSNP
rs1440822817 3958 dbSNP
rs1015539928 3960 dbSNP
rs530645983 3969 dbSNP
rs1168761119 3972 dbSNP
rs1007966852 3974 dbSNP
rs1005015293 3979 dbSNP
rs1463692155 3979 dbSNP
rs148219600 3981 dbSNP
rs1388136993 3997 dbSNP
rs1451094298 4013 dbSNP
rs953904043 4022 dbSNP
rs887864572 4029 dbSNP
rs1374712643 4040 dbSNP
rs1027673972 4050 dbSNP
rs1455089652 4051 dbSNP
rs1001505245 4053 dbSNP
rs1429649303 4057 dbSNP
rs1294905679 4060 dbSNP
rs1028001319 4067 dbSNP
rs1229577997 4069 dbSNP
rs1303325456 4070 dbSNP
rs1343401684 4075 dbSNP
rs995545131 4083 dbSNP
rs898752466 4087 dbSNP
rs1221041034 4093 dbSNP
rs143094372 4103 dbSNP
rs1446472798 4105 dbSNP
rs753845263 4111 dbSNP
rs1250120831 4116 dbSNP
rs1466099666 4117 dbSNP
rs1188891701 4119 dbSNP
rs1377032422 4123 dbSNP
rs1476972074 4132 dbSNP
rs1174223332 4138 dbSNP
rs1425309593 4143 dbSNP
rs896644607 4146 dbSNP
rs1056973877 4154 dbSNP
rs1399609234 4155 dbSNP
rs1318198466 4156 dbSNP
rs1390307627 4160 dbSNP
rs1197217745 4162 dbSNP
rs1436279888 4164 dbSNP
rs1325597310 4169 dbSNP
rs950049054 4173 dbSNP
rs1439272279 4178 dbSNP
rs938128390 4179 dbSNP
rs115874982 4188 dbSNP
rs1053370929 4202 dbSNP
rs1270256925 4210 dbSNP
rs780184997 4211 dbSNP
rs1234291897 4217 dbSNP
rs1209144337 4218 dbSNP
rs369149083 4219 dbSNP
rs935825454 4221 dbSNP
rs532724847 4229 dbSNP
rs1449621822 4230 dbSNP
rs1200995081 4234 dbSNP
rs925706102 4238 dbSNP
rs1349409409 4245 dbSNP
rs1156229278 4257 dbSNP
rs569059522 4262 dbSNP
rs1389112729 4264 dbSNP
rs756218263 4265 dbSNP
rs1301228604 4267 dbSNP
rs1233444007 4271 dbSNP
rs1324799672 4284 dbSNP
rs1335620182 4287 dbSNP
rs558925918 4299 dbSNP
rs914534318 4301 dbSNP
rs988721039 4322 dbSNP
rs1351156291 4325 dbSNP
rs1394519584 4326 dbSNP
rs1263897009 4330 dbSNP
rs955889067 4333 dbSNP
rs932370294 4334 dbSNP
rs1435481038 4351 dbSNP
rs142128053 4352 dbSNP
rs987007990 4356 dbSNP
rs953826378 4360 dbSNP
rs1028449995 4362 dbSNP
rs573669779 4380 dbSNP
rs1472632977 4382 dbSNP
rs1186478020 4383 dbSNP
rs181203548 4384 dbSNP
rs190425326 4393 dbSNP
rs962345282 4397 dbSNP
rs1370512090 4399 dbSNP
rs966701808 4406 dbSNP
rs1015140351 4408 dbSNP
rs1395511619 4409 dbSNP
rs1310859140 4416 dbSNP
rs576729281 4419 dbSNP
rs1246755799 4420 dbSNP
rs1015827077 4423 dbSNP
rs1284518423 4427 dbSNP
rs563834454 4433 dbSNP
rs1203022108 4434 dbSNP
rs1250707088 4434 dbSNP
rs1211146840 4437 dbSNP
rs1483106920 4439 dbSNP
rs561244849 4440 dbSNP
rs1035209347 4441 dbSNP
rs1425138714 4442 dbSNP
rs1002750489 4449 dbSNP
rs1277535374 4452 dbSNP
rs558452896 4453 dbSNP
rs1448042179 4454 dbSNP
rs1027767726 4458 dbSNP
rs1371646910 4460 dbSNP
rs1218609016 4462 dbSNP
rs1301122339 4466 dbSNP
rs1001598475 4469 dbSNP
rs138971724 4471 dbSNP
rs1320140934 4473 dbSNP
rs1364272232 4474 dbSNP
rs1044199173 4475 dbSNP
rs1225834482 4478 dbSNP
rs905955148 4480 dbSNP
rs1342736907 4481 dbSNP
rs1231919319 4485 dbSNP
rs1253790559 4487 dbSNP
rs888658289 4490 dbSNP
rs28562008 4494 dbSNP
rs1281084986 4496 dbSNP
rs1247018859 4499 dbSNP
rs891725404 4507 dbSNP
rs1236700063 4508 dbSNP
rs1433062083 4515 dbSNP
rs1174545782 4519 dbSNP
rs1334933738 4524 dbSNP
rs1288014686 4533 dbSNP
rs777212285 4534 dbSNP
rs1053012982 4547 dbSNP
rs566423996 4548 dbSNP
rs757427142 4552 dbSNP
rs935902186 4559 dbSNP
rs1386648594 4567 dbSNP
rs904379678 4568 dbSNP
rs1322243450 4570 dbSNP
rs28584782 4571 dbSNP
rs922310500 4578 dbSNP
rs976825309 4579 dbSNP
rs1053049923 4580 dbSNP
rs535516135 4581 dbSNP
rs934576379 4588 dbSNP
rs764466018 4589 dbSNP
rs1249084015 4590 dbSNP
rs952379722 4593 dbSNP
rs986651307 4596 dbSNP
rs1475962027 4605 dbSNP
rs932472259 4606 dbSNP
rs1208747363 4610 dbSNP
rs1410062561 4613 dbSNP
rs921056852 4629 dbSNP
rs568521034 4635 dbSNP
rs1203288976 4644 dbSNP
rs970123628 4645 dbSNP
rs1369557309 4646 dbSNP
rs1405059622 4647 dbSNP
rs1348060150 4648 dbSNP
rs1229891615 4650 dbSNP
rs550028126 4656 dbSNP
rs1284506837 4658 dbSNP
rs145146879 4659 dbSNP
rs769210053 4661 dbSNP
rs1014683283 4663 dbSNP
rs1357541290 4665 dbSNP
rs962376099 4667 dbSNP
rs1447483454 4668 dbSNP
rs1032071287 4674 dbSNP
rs1015231552 4679 dbSNP
rs1327092616 4683 dbSNP
rs185204721 4687 dbSNP
rs551213738 4688 dbSNP
rs1000154834 4689 dbSNP
rs960953494 4689 dbSNP
rs1351565328 4692 dbSNP
rs1388408488 4709 dbSNP
rs904431926 4712 dbSNP
rs1049594940 4713 dbSNP
rs1307303157 4718 dbSNP
rs1035642082 4721 dbSNP
rs1002416040 4722 dbSNP
rs905353738 4736 dbSNP
rs996641719 4744 dbSNP
rs1279779419 4745 dbSNP
rs900942957 4749 dbSNP
rs1462703717 4750 dbSNP
rs1315335908 4756 dbSNP
rs1360582357 4757 dbSNP
rs1205160333 4761 dbSNP
rs1040772907 4762 dbSNP
rs1415124859 4769 dbSNP
rs763358750 4773 dbSNP
rs1010979634 4775 dbSNP
rs892522860 4778 dbSNP
rs1237151119 4779 dbSNP
rs1482369090 4780 dbSNP
rs1183790686 4784 dbSNP
rs1475483470 4787 dbSNP
rs775943881 4791 dbSNP
rs1048533464 4805 dbSNP
rs1167900209 4806 dbSNP
rs1388175778 4812 dbSNP
rs1431141321 4813 dbSNP
rs1328894806 4815 dbSNP
rs1358048833 4816 dbSNP
rs944648112 4818 dbSNP
rs891082431 4832 dbSNP
rs1051444811 4838 dbSNP
rs1228049143 4845 dbSNP
rs1243313740 4847 dbSNP
rs1344885570 4854 dbSNP
rs920812109 4861 dbSNP
rs1278060916 4870 dbSNP
rs1440739008 4872 dbSNP
rs1212590748 4873 dbSNP
rs1243917095 4876 dbSNP
rs1190972625 4897 dbSNP
rs980242307 4904 dbSNP
rs1246144953 4906 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 771.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucGUCGUAACAUGU----CCCgauacu 5'
            | |||   ||||    |||      
Target 5' auCUGCACCUUACAACUCGGGgac--- 3'
 		13 - 36
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000178638.3 | 3UTR | ACAAAACCUUUAAUCUGCACCUUACAACUCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000178638.3 | 3UTR | ACAAAACCUUUAAUCUGCACCUUACAACUCGGGGACAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000178638.3 | 3UTR | ACAAAACCUUUAAUCUGCACCUUACAACUCGGGGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.53 3.1e-2 -0.621 1.2e-2 13 Click to see details
GSE28544 Breast cancer 0.284 8.9e-2 0.320 6.4e-2 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
53 hsa-miR-103b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT218386 E2F3 E2F transcription factor 3 2 2
MIRT404221 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT441502 SPG20 spartin 2 6
MIRT444124 ZNRF3 zinc and ring finger 3 2 2
MIRT454236 OSBPL10 oxysterol binding protein like 10 2 4
MIRT457919 ZNF212 zinc finger protein 212 2 2
MIRT462254 LAMA4 laminin subunit alpha 4 2 2
MIRT463176 ZNF281 zinc finger protein 281 2 2
MIRT472355 TSPAN1 tetraspanin 1 2 2
MIRT474133 LIN54 lin-54 DREAM MuvB core complex component 2 4
MIRT494946 IFFO2 intermediate filament family orphan 2 2 2
MIRT497403 NPY4R neuropeptide Y receptor Y4 2 2
MIRT497641 GLDN gliomedin 2 2
MIRT505340 TMEM245 transmembrane protein 245 2 6
MIRT505680 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT510706 SREK1IP1 SREK1 interacting protein 1 2 6
MIRT512198 C1orf43 chromosome 1 open reading frame 43 2 2
MIRT522089 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT525074 FRK fyn related Src family tyrosine kinase 2 2
MIRT531276 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT535119 PLXNA2 plexin A2 2 2
MIRT540836 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541018 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT545752 CA12 carbonic anhydrase 12 2 4
MIRT546404 SRP9 signal recognition particle 9 2 2
MIRT547991 HCFC2 host cell factor C2 2 4
MIRT554502 SAE1 SUMO1 activating enzyme subunit 1 2 2
MIRT558360 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT558863 CD2AP CD2 associated protein 2 2
MIRT559939 ZNF567 zinc finger protein 567 2 2
MIRT566300 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT567490 FOXK1 forkhead box K1 2 2
MIRT617139 ZNF556 zinc finger protein 556 2 2
MIRT625400 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT626491 CEP89 centrosomal protein 89 2 2
MIRT629487 GSN gelsolin 2 4
MIRT638456 PLXDC2 plexin domain containing 2 2 2
MIRT648498 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT654845 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT664587 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT664977 TDRD1 tudor domain containing 1 2 2
MIRT665028 ELK1 ELK1, ETS transcription factor 2 2
MIRT666043 STON2 stonin 2 2 2
MIRT668863 CRY2 cryptochrome circadian clock 2 2 2
MIRT669297 C17orf85 nuclear cap binding subunit 3 2 2
MIRT680975 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682267 RS1 retinoschisin 1 2 2
MIRT685283 KIAA1143 KIAA1143 2 2
MIRT693375 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT701785 MSL1 male specific lethal 1 homolog 2 2
MIRT709373 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2 2
MIRT715154 IL12B interleukin 12B 2 2
MIRT734499 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-103b Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-103b Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)

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