miRTarBase - #MIRT546187


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pre-miRNA Information
pre-miRNA hsa-mir-4473   
Genomic Coordinates chr9: 20411148 - 20411238
Description Homo sapiens miR-4473 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4473
Sequence 57| CUAGUGCUCUCCGUUACAAGUA |78
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs987949614 1 dbSNP
rs1199578146 4 dbSNP
rs1261784605 4 dbSNP
rs950939079 6 dbSNP
rs573478506 9 dbSNP
rs182397728 12 dbSNP
rs963590806 17 dbSNP
rs1452942530 19 dbSNP
rs1016614368 20 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TPD52   
Synonyms D52, N8L, PC-1, PrLZ, hD52
Description tumor protein D52
Transcript NM_001025252   
Other Transcripts NM_001025253 , NM_005079   
Expression
Putative miRNA Targets on TPD52
3'UTR of TPD52
(miRNA target sites are highlighted)		 
>TPD52|NM_001025252|3'UTR
   1 GATTCCTACCTTTGTTCTGCTACCCACTGCCAGATGCTGCAAGCGAGGTCCAAGCACATCTTGTCAACATGCATTGCCAT
  81 GAATTTCTACCAGATGTGCTTTTATTTAGCTTTACATATTCCTTTGACCAAATAGTTTGTGGGTTAAACAAAATGAAAAT
 161 ATCTTCACCTCTATTCTTGGGAAACACCCTTTAGTGTACATTTATGTTCCTTTATTTAGGAAACACCATTATAAAAACAC
 241 TTATAGTAAATGGGGACATTCACTATAATGATCTAAGAAGCTACAGATTGTCATAGTTGTTTTCCTGCTTTACAAAATTG
 321 CTCCAGATCTGGAATGCCAGTTTGACCTTTGTCTTCTATAATATTTCCTTTTTTTCCCCTCTTTGAATCTCTGTATATTT
 401 GATTCTTAACTAAAATTGTTCTCTTAAATATTCTGAATCCTGGTAATTAAAAGTTTGGGTGTATTTTCTTTACCTCCAAG
 481 GAAAGAACTACTAGCTACAAAAAATATTTTGGAATAAGCATTGTTTTGGTATAAGGTACATATTTTGGTTGAAGACACCA
 561 GACTGAAGTAAACAGCTGTGCATCCAATTTATTATAGTTTTGTAAGTAACAATATGTAATCAAACTTCTAGGTGACTTGA
 641 GAGTGGAACCTCCTATATCATTATTTAGCACCGTTTGTGACAGTAACCATTTCAGTGTATTGTTTATTATACCACTTATA
 721 TCAACTTATTTTTCACCAGGTTAAAATTTTAATTTCTACAAAATAACATTCTGAATCAAGCACACTGTATGTTCAGTAGG
 801 TTGAACTATGAACACTGTCATCAATGTTCAGTTCAAAAGCCTGAAAGTTTAGATCTAGAAGCTGGTAAAAATGACAATAT
 881 CAATCACATTAGGGGAACCATTGTTGTCTTCACTTAATCCATTTAGCACTATTTAAAATAAGCACACCAAGTTATATGAC
 961 TAATATAACTTGAAAATTTTTTATACTGAGGGGTTGGTGATAACTCTTGAGGATGTAATGCATTAATAAAAATCAACTCA
1041 TCATTTTCTACTTGTTTTCAATGTGTTGGAAACTGTAAAATGATACTGTAGAACCTGTCTCCTACTTTGAAAACTGAATG
1121 TCAGGGCTGAGTGAATCAAAGTGTCTAGACATATTTGCATAGAGGCCAAGGTATTCTATTCTAATAACTGCTTACTCAAC
1201 ACTACCACCTTTTCCTTATACTGTATATGATTATGGCCTACAATGTTGTATTTGTTATTTATTAAATTGTGATTGTTTTA
1281 TTATTGTTTATGCCAAATGTTAACTGCCAAGCTTGGAGTGACCTAAAGCATTTTTTAAAAGCATGGCTAGATTTACTTCA
1361 GTATAAATTATCTTATGAAAACCAAATTTTAAAAGCCACAGGTGTTGATTGTTATAAAATAACATGCTGCCATTCTTGAT
1441 TGCTAGAGTTTTTGTTAGTACTTTGGATGCAATTAAAACTATGTGCTATCACATGTGAAAAGCTTAATAAATTCCATCTA
1521 TCAGTAGTATAGGTCTCAATATTTATTATGAGACCAGTGGTCTGGAAACAGCTTGTTGTACCGAATCAACTGGAGTCTAT
1601 GCTTAAAAAAAAAAAATTTTTTTTTAACCATCCTTAAATTATTGCTTAATGGTATCATATTAACATATTCTAAATAAGGG
1681 CTTTAAGGCACAGGCTGTTGAAGCATTTTCTCAGAGGAGTGGATCTGTAGAAGTCTGTCTTTCTATAGAAATATTGTGCT
1761 TACTCAAGTGTTAAATTATTTTTTCTATGAACTAGTCTACTTCTTAAAATTCAAACATATTCTTTTGATCACATTGTTTC
1841 TTGAGCATCCTGCCCTGCTACTAACTTTTCAACAAGGCAAAATGGAGTAAAGTGGCAATTTCTTTAGATGAGTGAAATAC
1921 CCTCAAGTCTCTTTTCTGCCCAAAAAGGGAAAAGTGATAGAAATGGGGGTGGCAAGTGGGGTGAGTGGATGAAGGTGGGT
2001 ATTGGGGGTGGCTGTGAAAGAAAATAATGGAGAATCACTTTTCTAGACATCTACCTATACTTAATCTAAGAAACAAAGTA
2081 ATCTACTGTAAAGTACTCTGCCCCTTGAAAGAAGTATTAAAAAGAGTGAGGATGGATTTAGAAAAAAACATGAATTTAGA
2161 AATATTCAAAATGGTTTTTGTGGCAGATTCAATATTATGAATTCACAGATATTTAAAGAATGAGAAACATAGTAATTAGT
2241 AGAAATGCCAGAAACAGTTCCTGGTTCCTCTTGTGTTTGACACTAAGAAAATAGCAAGAGTGTGAAATCTCAGATACTTA
2321 TGAAATCTCACAGATGTAAGGACTCAAGTGTAGAAGAAAATATCCCCTTCTTACAAAAAGAAATGTCAATTTATGGAGTT
2401 TGTGGGAAATAGGGCAAGAATTCTTATGCTTATGAGAGCCAAGTAGTCAGTGGAAGAGAGTAGAGCTCAAAACTGGATTA
2481 TCACCTTAGCAACTTAGAATAGTTTGAAATAGAAAAAAAGTATTTAATTTGGATCTGGATCTGTTAAGATATGCACAGTC
2561 TATTTTTTGTATAGTATTGGAAAATAAAAATGCTATAATTTGGGTATGGGTTCTTTTGTATACATTACCTGCCCATTGAG
2641 GAAAGGGGCAAGTCCATTATGCAACTTCTCTCCAAACCCTTCATATTCTGGATATGATACTTAAAGAGCCATGAGCAGCT
2721 ACATTCTGCCTATCAGAAGGCATTTATTAAATGACTGCTTGCTGAAGATGTGTCCAAAGAGATCCTACATTAAGGTCATT
2801 TGTCAGAATGATGTTTGTGTTTGTTTAGAGTTGGCTGACCTCCAACTCCTGGGGTCAAGGAATCCTACTGCCTTAGCTTC
2881 CCAAATAGCTAGGACTATAGGCATGCACCCGGCCATGTGTTTTATTTATAGCTCTTAAAGCCCAGATGAAGAAATCACAT
2961 TTTTGCCCATAGTGAAGAAACATTTGGCCATTGATTAGTCCTTATTTTCAGTGACTGTCCTGTTTTCATTAGATTAGAGA
3041 GACCCTGTGTGGGCCACAGTTAATATAAACCATTATCACTTTTAAGTAAACCTGCACATCTTAGATTTCATAATTTCCTT
3121 ATTGTTCTGACTCAAAATGAACTAAGAGCTTTTCACTTTTTGTTTGTAAGTTCTCAGAGAGTCGGGTCTGCAAGTGCTTT
3201 TGCCTGCCAGGATTTTGTACTCAAATAAATGCTATTTGGCAACTAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augaacAUUGCCU--CUCGUGAUc 5'
                |||:  |   ||||||| 
Target 5' ttcactTAATCCATTTAGCACTAt 3'
 909 - 932 142.00 -7.37
2 
miRNA  3' auGAACAUUGCCUCUCGUGAUc 5'
            |||| ||  || ||:|:|| 
Target 5' ccCTTGAAA--GA-AGTATTAa 3'
 2102 - 2120 127.00 -5.70
3 
miRNA  3' auGAA---CAUUGCCUCUCGUGAuc 5'
            |||   ||:||  | ||||:|  
Target 5' agCTTGGAGTGACCTAAAGCATTtt 3'
 1310 - 1334 124.00 -9.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN19659220 45 COSMIC
COSN31598474 54 COSMIC
COSN28840518 67 COSMIC
COSN31535850 71 COSMIC
COSN30515173 79 COSMIC
COSN30160096 87 COSMIC
COSN30159819 93 COSMIC
COSN17453679 143 COSMIC
COSN28201288 285 COSMIC
COSN30172715 881 COSMIC
COSN23680340 1254 COSMIC
COSN26035358 1276 COSMIC
COSN31580157 1401 COSMIC
COSN29001159 1525 COSMIC
COSN28641025 1527 COSMIC
COSN31514755 1615 COSMIC
COSN23280017 1625 COSMIC
COSN29607843 1651 COSMIC
COSN31608975 1743 COSMIC
COSN30176807 1765 COSMIC
COSN32005929 2027 COSMIC
COSN5865483 2101 COSMIC
COSN19391907 2373 COSMIC
COSN27188211 2661 COSMIC
COSN27186496 2662 COSMIC
COSN21631300 2734 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780914440 1 dbSNP
rs768907862 4 dbSNP
rs747252624 7 dbSNP
rs780055022 8 dbSNP
rs758520020 14 dbSNP
rs1415444758 17 dbSNP
rs1184113140 21 dbSNP
rs750406632 33 dbSNP
rs1251000692 37 dbSNP
rs983877172 38 dbSNP
rs779599352 44 dbSNP
rs1802745 45 dbSNP
rs1220429009 48 dbSNP
rs754306174 50 dbSNP
rs764519706 51 dbSNP
rs1273648603 52 dbSNP
rs992486495 57 dbSNP
rs959948918 70 dbSNP
rs569497816 72 dbSNP
rs1226165176 74 dbSNP
rs912952404 90 dbSNP
rs1305344679 91 dbSNP
rs551034081 92 dbSNP
rs1031894523 95 dbSNP
rs552785156 98 dbSNP
rs1404904273 103 dbSNP
rs977607657 119 dbSNP
rs976403633 121 dbSNP
rs968860142 134 dbSNP
rs1250465583 136 dbSNP
rs1215270991 149 dbSNP
rs1339623910 161 dbSNP
rs1021745163 166 dbSNP
rs1007630637 178 dbSNP
rs889192279 181 dbSNP
rs1490112169 189 dbSNP
rs150178784 201 dbSNP
rs997545507 206 dbSNP
rs1430429898 222 dbSNP
rs1450383163 225 dbSNP
rs747233072 228 dbSNP
rs1028260586 229 dbSNP
rs1165653144 233 dbSNP
rs529311659 243 dbSNP
rs141101389 244 dbSNP
rs542306009 248 dbSNP
rs962139421 255 dbSNP
rs1364679410 263 dbSNP
rs779407484 272 dbSNP
rs1392608368 274 dbSNP
rs546689602 282 dbSNP
rs1382359048 287 dbSNP
rs747068593 289 dbSNP
rs1014273716 305 dbSNP
rs895839992 313 dbSNP
rs530150752 321 dbSNP
rs1034354071 329 dbSNP
rs561126335 335 dbSNP
rs1183306927 347 dbSNP
rs1262482771 357 dbSNP
rs1472914753 363 dbSNP
rs568136248 367 dbSNP
rs948497608 376 dbSNP
rs1009999670 379 dbSNP
rs1185699938 383 dbSNP
rs891546907 393 dbSNP
rs1042638 405 dbSNP
rs1347246082 434 dbSNP
rs1454779802 442 dbSNP
rs1320418169 444 dbSNP
rs1275289119 447 dbSNP
rs915680600 449 dbSNP
rs992957074 456 dbSNP
rs938367053 457 dbSNP
rs1310653096 459 dbSNP
rs752924044 461 dbSNP
rs924239895 471 dbSNP
rs1226463787 475 dbSNP
rs1230295724 480 dbSNP
rs1308886865 486 dbSNP
rs765015186 490 dbSNP
rs977683068 491 dbSNP
rs1040734942 494 dbSNP
rs968933681 494 dbSNP
rs1021776200 498 dbSNP
rs1208064650 511 dbSNP
rs943793636 521 dbSNP
rs986299304 523 dbSNP
rs953649457 537 dbSNP
rs910917154 538 dbSNP
rs1244043712 539 dbSNP
rs1049385723 541 dbSNP
rs1483048600 541 dbSNP
rs932254637 556 dbSNP
rs1420011076 563 dbSNP
rs754860651 567 dbSNP
rs1410372630 574 dbSNP
rs1287924178 592 dbSNP
rs753696971 594 dbSNP
rs1336815060 602 dbSNP
rs973571733 612 dbSNP
rs1445386922 620 dbSNP
rs1299485512 628 dbSNP
rs962170568 631 dbSNP
rs1227530247 643 dbSNP
rs997976009 646 dbSNP
rs1325582692 649 dbSNP
rs1223968357 652 dbSNP
rs546539739 653 dbSNP
rs1309180778 661 dbSNP
rs897834266 671 dbSNP
rs1457840422 672 dbSNP
rs1014933488 673 dbSNP
rs1481194170 679 dbSNP
rs530700132 697 dbSNP
rs1347672328 698 dbSNP
rs754222507 699 dbSNP
rs1481708367 705 dbSNP
rs766381545 709 dbSNP
rs1423893001 719 dbSNP
rs1034794732 720 dbSNP
rs1172147513 721 dbSNP
rs1001516391 725 dbSNP
rs1409055077 732 dbSNP
rs1166263413 740 dbSNP
rs1347094422 759 dbSNP
rs1004168489 764 dbSNP
rs888353097 780 dbSNP
rs1274141717 781 dbSNP
rs778159916 783 dbSNP
rs1344453677 785 dbSNP
rs1217529535 789 dbSNP
rs1405636060 789 dbSNP
rs1275454979 791 dbSNP
rs1343137427 796 dbSNP
rs755624205 801 dbSNP
rs969056369 803 dbSNP
rs1272950736 804 dbSNP
rs564753642 806 dbSNP
rs1010030943 808 dbSNP
rs1246613121 810 dbSNP
rs1252184620 817 dbSNP
rs544778923 824 dbSNP
rs1012763464 830 dbSNP
rs1166272201 835 dbSNP
rs528178252 850 dbSNP
rs1425034038 859 dbSNP
rs144110317 863 dbSNP
rs542347953 876 dbSNP
rs1434489271 877 dbSNP
rs1272006793 879 dbSNP
rs889530426 886 dbSNP
rs1049873751 891 dbSNP
rs79145344 894 dbSNP
rs1362099308 900 dbSNP
rs1210793855 909 dbSNP
rs767141106 942 dbSNP
rs920855370 943 dbSNP
rs1450396725 946 dbSNP
rs556971707 963 dbSNP
rs1041350179 965 dbSNP
rs560385720 975 dbSNP
rs1248126030 976 dbSNP
rs1226733496 983 dbSNP
rs761552520 991 dbSNP
rs544921547 1006 dbSNP
rs1386686320 1012 dbSNP
rs879615532 1019 dbSNP
rs1162429806 1025 dbSNP
rs986759776 1032 dbSNP
rs1402390178 1033 dbSNP
rs953580510 1035 dbSNP
rs544953692 1039 dbSNP
rs976235428 1057 dbSNP
rs1461529269 1061 dbSNP
rs1387201429 1065 dbSNP
rs767617921 1066 dbSNP
rs1245708157 1067 dbSNP
rs10098470 1073 dbSNP
rs1354624449 1075 dbSNP
rs1226004169 1083 dbSNP
rs993000380 1084 dbSNP
rs1464091912 1089 dbSNP
rs960414726 1094 dbSNP
rs927380420 1098 dbSNP
rs1442648032 1099 dbSNP
rs1186333284 1100 dbSNP
rs759983566 1102 dbSNP
rs748278274 1115 dbSNP
rs1471017013 1124 dbSNP
rs951995846 1126 dbSNP
rs1026908809 1127 dbSNP
rs1456839342 1133 dbSNP
rs562477844 1134 dbSNP
rs1191648214 1140 dbSNP
rs1396847727 1143 dbSNP
rs544341557 1148 dbSNP
rs1339116069 1149 dbSNP
rs1349171191 1151 dbSNP
rs955937967 1155 dbSNP
rs1289592014 1158 dbSNP
rs192437723 1160 dbSNP
rs1227025366 1161 dbSNP
rs1057359245 1170 dbSNP
rs1008032410 1189 dbSNP
rs1331459713 1192 dbSNP
rs1002653485 1201 dbSNP
rs747486420 1202 dbSNP
rs1253614940 1208 dbSNP
rs1439401425 1210 dbSNP
rs1182624998 1212 dbSNP
rs1028038985 1225 dbSNP
rs1178436305 1237 dbSNP
rs1233026831 1243 dbSNP
rs1379475067 1247 dbSNP
rs1041425761 1249 dbSNP
rs1172267016 1254 dbSNP
rs1400323067 1254 dbSNP
rs1310758952 1259 dbSNP
rs898203790 1261 dbSNP
rs1350193831 1262 dbSNP
rs111340419 1266 dbSNP
rs940952646 1269 dbSNP
rs1331222544 1272 dbSNP
rs914205028 1283 dbSNP
rs1442193721 1290 dbSNP
rs1050703702 1292 dbSNP
rs1317938995 1313 dbSNP
rs188773630 1348 dbSNP
rs1341042984 1360 dbSNP
rs923500418 1364 dbSNP
rs1481925276 1365 dbSNP
rs762790520 1373 dbSNP
rs867653469 1374 dbSNP
rs1198245711 1376 dbSNP
rs1433906229 1376 dbSNP
rs1057488893 1385 dbSNP
rs938821930 1387 dbSNP
rs183320915 1391 dbSNP
rs1042683 1398 dbSNP
rs1370370215 1399 dbSNP
rs1379087782 1412 dbSNP
rs779155909 1414 dbSNP
rs984838067 1423 dbSNP
rs1802744 1424 dbSNP
rs769755109 1428 dbSNP
rs952026437 1429 dbSNP
rs1386638641 1443 dbSNP
rs947470255 1446 dbSNP
rs1327623726 1447 dbSNP
rs1228718024 1455 dbSNP
rs191455137 1456 dbSNP
rs1339858645 1458 dbSNP
rs187796625 1459 dbSNP
rs1266034254 1464 dbSNP
rs1389685978 1472 dbSNP
rs958858182 1480 dbSNP
rs1186719526 1481 dbSNP
rs1488121746 1488 dbSNP
rs1035551883 1494 dbSNP
rs1191272736 1495 dbSNP
rs1265388771 1496 dbSNP
rs1262721947 1497 dbSNP
rs1002679718 1516 dbSNP
rs1451366435 1523 dbSNP
rs955969203 1524 dbSNP
rs1389760335 1525 dbSNP
rs1200029529 1530 dbSNP
rs1019504734 1532 dbSNP
rs902996468 1550 dbSNP
rs1020000704 1552 dbSNP
rs753629729 1556 dbSNP
rs1235741280 1572 dbSNP
rs567686242 1582 dbSNP
rs1342043343 1583 dbSNP
rs1435159833 1588 dbSNP
rs892843185 1590 dbSNP
rs1229613560 1594 dbSNP
rs1319539887 1594 dbSNP
rs898236534 1599 dbSNP
rs1294814879 1601 dbSNP
rs1230012278 1605 dbSNP
rs1050508158 1616 dbSNP
rs1463723961 1617 dbSNP
rs1466350130 1617 dbSNP
rs550528174 1617 dbSNP
rs555124532 1617 dbSNP
rs902076866 1619 dbSNP
rs182666299 1620 dbSNP
rs1415013881 1623 dbSNP
rs886696306 1625 dbSNP
rs1057349532 1626 dbSNP
rs938922463 1626 dbSNP
rs1393929745 1628 dbSNP
rs940845320 1630 dbSNP
rs571163502 1654 dbSNP
rs1404163008 1656 dbSNP
rs376105941 1665 dbSNP
rs908000856 1681 dbSNP
rs984910138 1688 dbSNP
rs1313239777 1693 dbSNP
rs199974609 1698 dbSNP
rs1303027538 1704 dbSNP
rs930706524 1710 dbSNP
rs756011126 1714 dbSNP
rs947502751 1725 dbSNP
rs991208998 1729 dbSNP
rs1227649086 1730 dbSNP
rs139271337 1732 dbSNP
rs1315162504 1735 dbSNP
rs776204937 1738 dbSNP
rs190004860 1745 dbSNP
rs988789643 1753 dbSNP
rs1180472965 1754 dbSNP
rs934623471 1756 dbSNP
rs1473214363 1759 dbSNP
rs551169993 1760 dbSNP
rs912545853 1766 dbSNP
rs986774878 1773 dbSNP
rs954082059 1779 dbSNP
rs1176400539 1785 dbSNP
rs564143394 1785 dbSNP
rs185245639 1791 dbSNP
rs1187187659 1795 dbSNP
rs1422266724 1797 dbSNP
rs1258755972 1805 dbSNP
rs1036031233 1820 dbSNP
rs1028187934 1825 dbSNP
rs973875508 1827 dbSNP
rs1409168232 1833 dbSNP
rs981291531 1837 dbSNP
rs1286344021 1843 dbSNP
rs962473490 1845 dbSNP
rs967187272 1849 dbSNP
rs1279684411 1853 dbSNP
rs1020072726 1854 dbSNP
rs1208930850 1861 dbSNP
rs1277244051 1864 dbSNP
rs559279238 1865 dbSNP
rs1273126087 1875 dbSNP
rs1011317202 1888 dbSNP
rs960435285 1889 dbSNP
rs1250222905 1892 dbSNP
rs1478759074 1896 dbSNP
rs1207837738 1897 dbSNP
rs1339573408 1898 dbSNP
rs892865900 1900 dbSNP
rs1423782921 1902 dbSNP
rs1283079195 1905 dbSNP
rs1170051241 1910 dbSNP
rs750452497 1912 dbSNP
rs996265164 1916 dbSNP
rs901473049 1918 dbSNP
rs1040649627 1924 dbSNP
rs1428838498 1934 dbSNP
rs1306163761 1936 dbSNP
rs1351541005 1939 dbSNP
rs1437021612 1947 dbSNP
rs35636461 1950 dbSNP
rs1275531285 1953 dbSNP
rs1003148623 1958 dbSNP
rs1232414497 1965 dbSNP
rs906094620 1968 dbSNP
rs1044582234 1970 dbSNP
rs372755321 1972 dbSNP
rs1204873369 1973 dbSNP
rs79476175 1981 dbSNP
rs940918821 1982 dbSNP
rs1293488182 1983 dbSNP
rs1222887888 1995 dbSNP
rs1011676695 2005 dbSNP
rs1190159484 2008 dbSNP
rs1348331529 2009 dbSNP
rs1390385415 2014 dbSNP
rs886639236 2043 dbSNP
rs542735894 2054 dbSNP
rs1448712078 2062 dbSNP
rs528961338 2064 dbSNP
rs182001574 2081 dbSNP
rs916670697 2088 dbSNP
rs934743797 2089 dbSNP
rs543412203 2091 dbSNP
rs1350393144 2100 dbSNP
rs1349416190 2109 dbSNP
rs1438776534 2114 dbSNP
rs990890775 2122 dbSNP
rs939356887 2124 dbSNP
rs1397374612 2131 dbSNP
rs151276904 2131 dbSNP
rs927947685 2132 dbSNP
rs1162713226 2138 dbSNP
rs981364178 2144 dbSNP
rs1358860354 2149 dbSNP
rs75969194 2151 dbSNP
rs1289764949 2152 dbSNP
rs1420329712 2153 dbSNP
rs79275443 2162 dbSNP
rs921158152 2206 dbSNP
rs1248028654 2209 dbSNP
rs1472472664 2214 dbSNP
rs973906760 2215 dbSNP
rs962505624 2220 dbSNP
rs1239022600 2222 dbSNP
rs573415797 2228 dbSNP
rs1472988192 2233 dbSNP
rs1162645822 2235 dbSNP
rs908365002 2248 dbSNP
rs1460004732 2255 dbSNP
rs989924536 2255 dbSNP
rs1161470314 2260 dbSNP
rs1438881020 2261 dbSNP
rs1434684867 2268 dbSNP
rs982566721 2270 dbSNP
rs1288577462 2276 dbSNP
rs957207087 2301 dbSNP
rs1342687040 2311 dbSNP
rs1207584355 2315 dbSNP
rs1284192779 2320 dbSNP
rs1357793635 2321 dbSNP
rs1029165211 2322 dbSNP
rs1327827719 2324 dbSNP
rs1034718682 2325 dbSNP
rs1280274336 2334 dbSNP
rs553278974 2335 dbSNP
rs1186573776 2337 dbSNP
rs1002248242 2340 dbSNP
rs575781244 2341 dbSNP
rs114676196 2345 dbSNP
rs1023133292 2346 dbSNP
rs1412844732 2366 dbSNP
rs557103393 2368 dbSNP
rs1157106859 2371 dbSNP
rs762532918 2389 dbSNP
rs1011707879 2393 dbSNP
rs1289968363 2394 dbSNP
rs1415186505 2398 dbSNP
rs1333936049 2399 dbSNP
rs893345871 2405 dbSNP
rs1442899167 2407 dbSNP
rs966140296 2410 dbSNP
rs1330413734 2415 dbSNP
rs1412261533 2415 dbSNP
rs774790312 2417 dbSNP
rs1236237874 2420 dbSNP
rs1385177924 2427 dbSNP
rs567394448 2434 dbSNP
rs1199472603 2435 dbSNP
rs886671953 2436 dbSNP
rs1483894334 2439 dbSNP
rs1205839927 2440 dbSNP
rs1166013610 2442 dbSNP
rs1250966725 2443 dbSNP
rs1049318618 2444 dbSNP
rs1410281223 2452 dbSNP
rs1179754752 2459 dbSNP
rs1379384579 2461 dbSNP
rs995427407 2463 dbSNP
rs1173208051 2465 dbSNP
rs191858261 2470 dbSNP
rs1309230865 2475 dbSNP
rs932607776 2492 dbSNP
rs771206492 2495 dbSNP
rs1055621579 2497 dbSNP
rs1246661501 2500 dbSNP
rs939450509 2507 dbSNP
rs921201003 2517 dbSNP
rs928004147 2519 dbSNP
rs1042358705 2520 dbSNP
rs1232127005 2520 dbSNP
rs1331135671 2520 dbSNP
rs1344114990 2523 dbSNP
rs1253074722 2527 dbSNP
rs1273565035 2533 dbSNP
rs945992396 2538 dbSNP
rs982598006 2554 dbSNP
rs761244726 2556 dbSNP
rs989999481 2557 dbSNP
rs1193296222 2558 dbSNP
rs1393487529 2559 dbSNP
rs1451795225 2569 dbSNP
rs957433306 2571 dbSNP
rs980466348 2583 dbSNP
rs773769696 2595 dbSNP
rs117386299 2609 dbSNP
rs1295763489 2610 dbSNP
rs1224156692 2620 dbSNP
rs965808572 2622 dbSNP
rs1343966711 2635 dbSNP
rs1018644513 2639 dbSNP
rs1439499585 2647 dbSNP
rs529140442 2659 dbSNP
rs1021913925 2660 dbSNP
rs1004568919 2675 dbSNP
rs990385015 2678 dbSNP
rs1435290659 2683 dbSNP
rs187020756 2694 dbSNP
rs1305508947 2698 dbSNP
rs1246956168 2708 dbSNP
rs1373364573 2713 dbSNP
rs181509980 2721 dbSNP
rs748268364 2731 dbSNP
rs796087794 2733 dbSNP
rs1357213357 2753 dbSNP
rs1213138261 2762 dbSNP
rs1251150579 2764 dbSNP
rs1466435994 2766 dbSNP
rs528352696 2770 dbSNP
rs973677484 2771 dbSNP
rs1027915709 2772 dbSNP
rs1427083908 2782 dbSNP
rs995061674 2783 dbSNP
rs1369542894 2792 dbSNP
rs1461315344 2795 dbSNP
rs868329997 2796 dbSNP
rs377011354 2817 dbSNP
rs1162188066 2823 dbSNP
rs1390140828 2828 dbSNP
rs1320479826 2829 dbSNP
rs528903407 2845 dbSNP
rs899876172 2846 dbSNP
rs1055292283 2849 dbSNP
rs1359669557 2850 dbSNP
rs1004065351 2854 dbSNP
rs1313435345 2861 dbSNP
rs749833814 2869 dbSNP
rs1231322278 2873 dbSNP
rs752109284 2878 dbSNP
rs886997119 2898 dbSNP
rs1280015991 2910 dbSNP
rs906610410 2911 dbSNP
rs1485134214 2912 dbSNP
rs1042430875 2913 dbSNP
rs548867725 2914 dbSNP
rs1395210465 2919 dbSNP
rs915200671 2928 dbSNP
rs1186374296 2929 dbSNP
rs1457292055 2936 dbSNP
rs1157997730 2939 dbSNP
rs980964039 2940 dbSNP
rs561859289 2951 dbSNP
rs1187350698 2953 dbSNP
rs1054817191 2954 dbSNP
rs935923861 2961 dbSNP
rs1467202783 2968 dbSNP
rs189869625 2969 dbSNP
rs1374577581 2975 dbSNP
rs974584303 2977 dbSNP
rs989076885 2979 dbSNP
rs1215986937 2981 dbSNP
rs778998001 2984 dbSNP
rs1306292068 3008 dbSNP
rs1315361708 3013 dbSNP
rs1212447967 3019 dbSNP
rs1256985287 3025 dbSNP
rs965843780 3035 dbSNP
rs867774432 3037 dbSNP
rs1236474212 3041 dbSNP
rs1348470427 3042 dbSNP
rs768875701 3044 dbSNP
rs1472672104 3069 dbSNP
rs957634889 3071 dbSNP
rs1405092639 3072 dbSNP
rs1227794005 3076 dbSNP
rs1031843706 3077 dbSNP
rs977623847 3082 dbSNP
rs955761750 3086 dbSNP
rs1371090542 3091 dbSNP
rs1441312896 3092 dbSNP
rs1297702345 3101 dbSNP
rs1371223489 3111 dbSNP
rs1221193962 3116 dbSNP
rs1304412046 3121 dbSNP
rs983165165 3124 dbSNP
rs950366034 3127 dbSNP
rs563325098 3135 dbSNP
rs1277132656 3158 dbSNP
rs1363052916 3160 dbSNP
rs112544979 3168 dbSNP
rs371603956 3168 dbSNP
rs1230714678 3172 dbSNP
rs1027320713 3173 dbSNP
rs1431746067 3177 dbSNP
rs549894360 3180 dbSNP
rs1170262050 3182 dbSNP
rs148730028 3183 dbSNP
rs564051952 3184 dbSNP
rs899907159 3191 dbSNP
rs199770008 3196 dbSNP
rs1332582976 3206 dbSNP
rs78054728 3211 dbSNP
rs573424620 3219 dbSNP
rs1003734006 3220 dbSNP
rs1370539401 3222 dbSNP
rs1376622182 3232 dbSNP
rs906683996 3234 dbSNP
rs1300293237 3235 dbSNP
rs1340451255 3237 dbSNP
rs1214546229 3240 dbSNP
rs1005533831 3242 dbSNP
rs887028142 3243 dbSNP
rs1047388913 3251 dbSNP
rs1251768623 3255 dbSNP
rs1444353740 3257 dbSNP
rs1466873767 3259 dbSNP
rs1190058961 3263 dbSNP
rs749474267 3266 dbSNP
rs74929425 3272 dbSNP
rs906382241 3275 dbSNP
rs760806380 3277 dbSNP
rs1420941794 3279 dbSNP
rs1405817653 3284 dbSNP
rs1165766756 3289 dbSNP
rs145697804 3291 dbSNP
rs1460103281 3293 dbSNP
rs546627367 3302 dbSNP
rs1472249725 3309 dbSNP
rs755919709 3313 dbSNP
rs914968479 3325 dbSNP
rs573807830 3326 dbSNP
rs1053778218 3327 dbSNP
rs1053385470 3328 dbSNP
rs1235567484 3336 dbSNP
rs935939094 3340 dbSNP
rs1272019622 3347 dbSNP
rs140165958 3349 dbSNP
rs1212799690 3351 dbSNP
rs1485848487 3352 dbSNP
rs1284499705 3362 dbSNP
rs1446278052 3367 dbSNP
rs537143464 3368 dbSNP
rs577642977 3369 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7163.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augaacauugccucUCGUGAUc 5'
                        ||||||| 
Target 5' -------------uAGCACUAu 3'
 		1 - 9
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000379096.5 | 3UTR | CACUAUUUAAAAUAAGCACACCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000379096.5 | 3UTR | CACUAUUUAAAAUAAGCACACCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000379096.5 | 3UTR | UAGCACUAUUUAAAAUAAGCACACCAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
53 hsa-miR-4473 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT193963 GLCE glucuronic acid epimerase 2 2
MIRT232832 NUPL1 nucleoporin 58 2 2
MIRT306237 ZMAT3 zinc finger matrin-type 3 2 4
MIRT441353 ZNF75A zinc finger protein 75a 2 2
MIRT443665 FLT1 fms related tyrosine kinase 1 2 2
MIRT448553 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT448625 OSBPL8 oxysterol binding protein like 8 2 2
MIRT449138 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT462942 ZNF800 zinc finger protein 800 2 12
MIRT463962 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT466315 THRA thyroid hormone receptor, alpha 2 2
MIRT493504 IL6ST interleukin 6 signal transducer 2 2
MIRT502727 CLIP1 CAP-Gly domain containing linker protein 1 2 8
MIRT503464 ZNF154 zinc finger protein 154 2 6
MIRT506738 LMLN leishmanolysin like peptidase 2 4
MIRT507282 FEM1B fem-1 homolog B 2 2
MIRT510711 SPG20 spartin 2 6
MIRT524495 CEP170 centrosomal protein 170 2 4
MIRT529425 MALT1 MALT1 paracaspase 2 2
MIRT533482 TRIM71 tripartite motif containing 71 2 2
MIRT533715 TMEM30A transmembrane protein 30A 2 2
MIRT534115 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT534473 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT536519 KCTD10 potassium channel tetramerization domain containing 10 2 2
MIRT537263 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537597 ESRP2 epithelial splicing regulatory protein 2 2 2
MIRT537918 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT538074 DIAPH2 diaphanous related formin 2 2 2
MIRT538707 CAPRIN2 caprin family member 2 2 4
MIRT546187 TPD52 tumor protein D52 2 4
MIRT546942 SFTPA1 surfactant protein A1 2 2
MIRT549590 TMEM101 transmembrane protein 101 2 2
MIRT551686 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT551948 RNF157 ring finger protein 157 2 2
MIRT553176 UBE2D2 ubiquitin conjugating enzyme E2 D2 2 2
MIRT555074 PURG purine rich element binding protein G 2 2
MIRT556214 MB21D2 Mab-21 domain containing 2 2 2
MIRT556476 LIPA lipase A, lysosomal acid type 2 2
MIRT556683 KLHL28 kelch like family member 28 2 2
MIRT556863 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT558402 DEPDC1 DEP domain containing 1 2 2
MIRT558716 CLCN3 chloride voltage-gated channel 3 2 2
MIRT559512 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT566872 LRP12 LDL receptor related protein 12 2 2
MIRT567038 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT574515 PRC1 protein regulator of cytokinesis 1 2 2
MIRT642220 RABAC1 Rab acceptor 1 2 2
MIRT651915 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT654128 RPL14 ribosomal protein L14 2 2
MIRT654344 RBM27 RNA binding motif protein 27 2 2
MIRT669250 C4orf36 chromosome 4 open reading frame 36 2 2
MIRT683176 UBL3 ubiquitin like 3 2 2
MIRT718768 ABHD15 abhydrolase domain containing 15 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4473 Plx-4720 24180719 NSC757438 resistant High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-4473 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-4473 Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-4473 Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-4473 Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-4473 Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-4473 Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-mir-4473 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-4473 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4473 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4473 Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil resistant tissue (myasthenia gravis)

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