pre-miRNA Information
pre-miRNA hsa-mir-569   
Genomic Coordinates chr3: 171106664 - 171106759
Synonyms MIRN569, hsa-mir-569, MIR569
Description Homo sapiens miR-569 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-569
Sequence 61| AGUUAAUGAAUCCUGGAAAGU |81
Evidence Experimental
Experiments SAGE
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN23021417 4 COSMIC
COSN1083370 8 COSMIC
COSN30455038 12 COSMIC
COSN24300323 13 COSMIC
COSN32068274 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs752673293 5 dbSNP
rs1218920077 8 dbSNP
rs745722313 12 dbSNP
rs1368837885 14 dbSNP
Putative Targets

Gene Information
Gene Symbol RNF6   
Synonyms -
Description ring finger protein 6
Transcript NM_183043   
Other Transcripts NM_005977 , NM_183044   
Expression
Putative miRNA Targets on RNF6
3'UTR of RNF6
(miRNA target sites are highlighted)
>RNF6|NM_183043|3'UTR
   1 GGTGATGGGATCTACTCAAATACTGTTTTTTAGTAGAACTGAATGTTCAAGCATTGTTTTGCTGAGTTATTTGTGATTAG
  81 CTAACCAGGATGAAAAATAACAGATTATATATAGTTTGAACTATTTTTCGTGTGCTTTTTTAAACTTGTTAAAAAGAAAT
 161 TTATATAAAATTTAAAATACAAATGTTAAATTATCCAGAAATACAGAATAGTTAATATTGCTAGAACCAAATAACCTCTA
 241 AAATGTTTTTATTTTGGTAATTTTGTCATGCTAAGCACTTTTGTATCTGCACAATTCAGTAGGTTAAGAATCAATCTTCT
 321 TTTTCTTAATAGTACAGCAGACTTTAGCTTCAAGTTTCATAGGCTTAGTACTTATATCTAGACATTTGTGTCTAAATAAG
 401 CTTTTCATTAACTTTTTATTTTAAGGACAGTATCTTTTCATGAAAGAGTATTTGGCTGAATGTTTGCTATATATATGTTA
 481 CTTGAAATGTTAAATTTAATATGCAGCATACCATAGGTGTATATATAGGTATATAATTTTAAGGTTAAAATATTCAGTCT
 561 ACAAGTTTGGTTCTTATTTAAGCTTTTGGGCTAATACTGCATATGGCACAATGTTTAATATTGGCAAGTTCATCTCAGAG
 641 AAAGGGGATTCAGATATAATTTTAAAGTAGAGATAATTTACTGAAGCGTCTCTGACAATCTAACTTATTAGACAGCAAGC
 721 AATATATAATACTGAAAAAGTATTCAGAAATGGAAAATTTACATCATATAGGTTATTTAACTTGTGTTCAGCCTTTTTGT
 801 AACTTTTTTGAAAGTGCAAACAATTCTTTGGATTATTAAATAAGGTATACAGTATGCATGGTTTCTCAAATTTAGTTTTA
 881 AAATCTAAAAGTCTATAAAGAATCAGATGCATAGGCAATATGTTAAGTTCACTTGGAGGCTAAAAATCTCCAGTGAAAAC
 961 AAAACGAAAACCTTTAAGAGAATGTAGAGTTTATATAAACACAAAGTATGCATTGAAGATCTGTTTCTACCAATAAACAT
1041 TAAAACAAAGACTGTAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugaaagguccuAAGUAAUUGa 5'
                     ||||||||| 
Target 5' taaataagcttTTCATTAACt 3'
393 - 413 150.00 -8.80
2
miRNA  3' ugAAAGGUCCUAA---GUAAUUga 5'
            ||||:|  | |   ||||||  
Target 5' tgTTTCTACCAATAAACATTAAaa 3'
1022 - 1045 135.00 -5.40
3
miRNA  3' ugaAAGGUCCUAAGUAAUUga 5'
             |||:  |: |:|||||  
Target 5' caaTTCTTTGGATTATTAAat 3'
821 - 841 122.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28839471 5 COSMIC
COSN26992496 8 COSMIC
COSN30155891 12 COSMIC
COSN30497260 25 COSMIC
COSN30450218 36 COSMIC
COSN30157606 41 COSMIC
COSN30192840 76 COSMIC
COSN25921923 93 COSMIC
COSN30520592 129 COSMIC
COSN31527747 156 COSMIC
COSN31541278 186 COSMIC
COSN1157024 190 COSMIC
COSN31490232 282 COSMIC
COSN31590620 327 COSMIC
COSN28709719 351 COSMIC
COSN31517749 400 COSMIC
COSN6225124 430 COSMIC
COSN31563688 469 COSMIC
COSN29801544 573 COSMIC
COSN31569151 606 COSMIC
COSN31608165 640 COSMIC
COSN29303819 757 COSMIC
COSN31571393 826 COSMIC
COSN28202262 849 COSMIC
COSN28791184 850 COSMIC
COSN31585768 966 COSMIC
COSN32055796 997 COSMIC
COSN31485938 1036 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1394916990 1 dbSNP
rs753573634 2 dbSNP
rs779802161 7 dbSNP
rs1387316134 15 dbSNP
rs755801417 17 dbSNP
rs1410335680 20 dbSNP
rs1023159518 21 dbSNP
rs1470080680 23 dbSNP
rs1236831609 24 dbSNP
rs768476849 26 dbSNP
rs1196023137 31 dbSNP
rs1367191172 32 dbSNP
rs1469219973 33 dbSNP
rs767215878 34 dbSNP
rs1464011477 38 dbSNP
rs761872332 39 dbSNP
rs1319491889 44 dbSNP
rs751397041 48 dbSNP
rs539577278 52 dbSNP
rs1400472123 53 dbSNP
rs1410010291 68 dbSNP
rs1328789586 69 dbSNP
rs990383358 78 dbSNP
rs772288038 84 dbSNP
rs1228626855 86 dbSNP
rs1311782065 89 dbSNP
rs1319823946 102 dbSNP
rs1172301245 105 dbSNP
rs1220448982 111 dbSNP
rs957529973 114 dbSNP
rs1031833747 116 dbSNP
rs143463322 123 dbSNP
rs901594315 129 dbSNP
rs557296912 130 dbSNP
rs1181604846 132 dbSNP
rs537066819 139 dbSNP
rs1254568141 140 dbSNP
rs780374785 142 dbSNP
rs1234792019 144 dbSNP
rs1172104750 167 dbSNP
rs1182667639 167 dbSNP
rs1464600733 168 dbSNP
rs888819117 172 dbSNP
rs753373197 179 dbSNP
rs1448355411 190 dbSNP
rs1302022531 195 dbSNP
rs1441908302 198 dbSNP
rs549165464 203 dbSNP
rs548604120 220 dbSNP
rs930587083 221 dbSNP
rs1278697225 233 dbSNP
rs528684972 238 dbSNP
rs1036206304 240 dbSNP
rs1280872319 244 dbSNP
rs940095471 251 dbSNP
rs1209747409 265 dbSNP
rs529390690 269 dbSNP
rs1254628938 276 dbSNP
rs549133085 283 dbSNP
rs928724072 283 dbSNP
rs1263041891 285 dbSNP
rs1208562342 298 dbSNP
rs1184227351 301 dbSNP
rs981578106 314 dbSNP
rs1414669810 317 dbSNP
rs948708377 319 dbSNP
rs749246409 322 dbSNP
rs1280721885 323 dbSNP
rs990352333 329 dbSNP
rs1298612183 332 dbSNP
rs185318248 345 dbSNP
rs957624877 346 dbSNP
rs192302916 353 dbSNP
rs187933051 358 dbSNP
rs1368477422 359 dbSNP
rs543363701 375 dbSNP
rs529658384 378 dbSNP
rs965797117 383 dbSNP
rs1356154689 393 dbSNP
rs1019100019 403 dbSNP
rs1007333209 410 dbSNP
rs888782286 411 dbSNP
rs1027358204 418 dbSNP
rs1376466039 421 dbSNP
rs1478036054 424 dbSNP
rs182162193 439 dbSNP
rs1392834565 446 dbSNP
rs1399285079 449 dbSNP
rs1158999617 450 dbSNP
rs897762582 457 dbSNP
rs1417778438 458 dbSNP
rs1410518452 462 dbSNP
rs1350416607 469 dbSNP
rs1435791683 471 dbSNP
rs1159310097 497 dbSNP
rs1472513994 499 dbSNP
rs1255443748 503 dbSNP
rs17083434 509 dbSNP
rs1352050394 516 dbSNP
rs1003773861 521 dbSNP
rs1486640890 526 dbSNP
rs191406434 529 dbSNP
rs1250647733 530 dbSNP
rs116536064 543 dbSNP
rs1178935720 545 dbSNP
rs1379304514 549 dbSNP
rs948863890 555 dbSNP
rs1285930037 558 dbSNP
rs1223928461 560 dbSNP
rs1323949882 561 dbSNP
rs1402623435 568 dbSNP
rs1447790259 569 dbSNP
rs572430294 586 dbSNP
rs1330854995 601 dbSNP
rs1374981756 604 dbSNP
rs1247387198 609 dbSNP
rs1333559492 610 dbSNP
rs1356231871 611 dbSNP
rs1227161475 613 dbSNP
rs775178274 616 dbSNP
rs544824990 620 dbSNP
rs1198746295 625 dbSNP
rs1234567581 627 dbSNP
rs1356702168 636 dbSNP
rs1189326443 638 dbSNP
rs554226164 641 dbSNP
rs1472419907 642 dbSNP
rs1429128184 645 dbSNP
rs1347254128 646 dbSNP
rs188188192 647 dbSNP
rs924881097 650 dbSNP
rs1425696590 657 dbSNP
rs1466162693 674 dbSNP
rs1170099992 677 dbSNP
rs1394561602 678 dbSNP
rs1319269465 687 dbSNP
rs1335256175 699 dbSNP
rs879076698 701 dbSNP
rs182868386 702 dbSNP
rs1415931097 708 dbSNP
rs72166737 711 dbSNP
rs1475574900 713 dbSNP
rs191490411 719 dbSNP
rs1256917738 725 dbSNP
rs966595694 729 dbSNP
rs1201882387 762 dbSNP
rs912102506 769 dbSNP
rs986276802 776 dbSNP
rs1414521374 781 dbSNP
rs953116628 783 dbSNP
rs1265196306 790 dbSNP
rs866454495 793 dbSNP
rs1478129913 797 dbSNP
rs1193011884 802 dbSNP
rs537405505 807 dbSNP
rs1371464277 810 dbSNP
rs186584983 816 dbSNP
rs1474305778 823 dbSNP
rs994516703 826 dbSNP
rs746407951 829 dbSNP
rs1243590666 832 dbSNP
rs1216090527 833 dbSNP
rs961734559 853 dbSNP
rs1361701568 854 dbSNP
rs367558929 870 dbSNP
rs560052205 870 dbSNP
rs1294218943 874 dbSNP
rs1830 876 dbSNP
rs1215089919 888 dbSNP
rs1234789534 895 dbSNP
rs1334900078 897 dbSNP
rs906349236 907 dbSNP
rs535377034 908 dbSNP
rs867074043 910 dbSNP
rs1215885073 914 dbSNP
rs1488568173 914 dbSNP
rs1259577391 916 dbSNP
rs1013375855 917 dbSNP
rs1199699027 927 dbSNP
rs1271190862 929 dbSNP
rs755722685 947 dbSNP
rs1440593109 963 dbSNP
rs894583735 965 dbSNP
rs747682798 966 dbSNP
rs1160804791 970 dbSNP
rs1361642693 980 dbSNP
rs935992793 992 dbSNP
rs1287565546 1002 dbSNP
rs757645036 1005 dbSNP
rs753120786 1012 dbSNP
rs566258396 1019 dbSNP
rs1240869057 1023 dbSNP
rs1042359669 1050 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 6049.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugaaagguccuAAGUAAUUGa 5'
                     ||||||||| 
Target 5' --------cuuUUCAUUAACu 3'
1 - 13
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000346166.3 | 3UTR | CUUUUCAUUAACUUUUUAUUUUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21849 B cell lymphoma -0.536 1.4e-3 -0.433 9.5e-3 29 Click to see details
GSE28544 Breast cancer -0.469 1.0e-2 -0.492 7.3e-3 24 Click to see details
GSE28260 Renal cortex and medulla -0.519 3.5e-2 -0.352 1.2e-1 13 Click to see details
GSE17306 Multiple myeloma 0.241 4.8e-2 0.528 4.8e-5 49 Click to see details
GSE14794 Lymphoblastoid cells 0.171 5.4e-2 0.189 3.7e-2 90 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.298 7.4e-2 0.222 1.4e-1 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.207 1.7e-1 0.161 2.3e-1 24 Click to see details
GSE32688 Pancreatic cancer 0.092 3.1e-1 0.109 2.8e-1 32 Click to see details
GSE27834 Pluripotent stem cells -0.115 3.4e-1 -0.191 2.4e-1 16 Click to see details
GSE42095 Differentiated embryonic stem cells -0.088 3.4e-1 -0.086 3.5e-1 23 Click to see details
GSE21687 Ependynoma primary tumors 0.043 3.7e-1 -0.008 4.7e-1 64 Click to see details
GSE17498 Multiple myeloma -0.054 3.7e-1 0.034 4.2e-1 40 Click to see details
GSE38226 Liver fibrosis 0.068 3.8e-1 0.065 3.9e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.001 5.0e-1 -0.568 4.5e-3 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.001 5.0e-1 -0.568 4.5e-3 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.001 5.0e-1 -0.568 4.5e-3 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.001 5.0e-1 -0.568 4.5e-3 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
58 hsa-miR-569 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004827 SPI1 Spi-1 proto-oncogene 2 1
MIRT086537 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086545 MOB4 MOB family member 4, phocein 2 2
MIRT154349 PARD6B par-6 family cell polarity regulator beta 2 4
MIRT182174 POU2F1 POU class 2 homeobox 1 2 2
MIRT190452 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT191410 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT199846 CSNK1G2 casein kinase 1 gamma 2 2 2
MIRT208376 SLC25A36 solute carrier family 25 member 36 2 2
MIRT275677 CARKD NAD(P)HX dehydratase 2 2
MIRT275764 TFDP1 transcription factor Dp-1 2 2
MIRT280470 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2 2
MIRT296592 FAM217B family with sequence similarity 217 member B 2 4
MIRT306847 FYTTD1 forty-two-three domain containing 1 2 2
MIRT443764 HLF HLF, PAR bZIP transcription factor 2 2
MIRT448026 GSR glutathione-disulfide reductase 2 2
MIRT448659 NCALD neurocalcin delta 2 2
MIRT449142 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT449225 RAD51B RAD51 paralog B 2 2
MIRT462421 TWISTNB TWIST neighbor 2 2
MIRT468478 SESN3 sestrin 3 2 4
MIRT478170 DENND5B DENN domain containing 5B 2 2
MIRT478577 VSIG2 V-set and immunoglobulin domain containing 2 2 2
MIRT481300 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 16
MIRT485894 ZFP36 ZFP36 ring finger protein 2 2
MIRT497242 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT500282 ZNF703 zinc finger protein 703 2 8
MIRT509536 RSBN1L round spermatid basic protein 1 like 2 4
MIRT511835 GPATCH8 G-patch domain containing 8 2 4
MIRT522437 MON1B MON1 homolog B, secretory trafficking associated 2 2
MIRT523538 GLO1 glyoxalase I 2 4
MIRT527631 MYBPC1 myosin binding protein C, slow type 2 4
MIRT528059 OLAH oleoyl-ACP hydrolase 2 2
MIRT532549 TXNL1 thioredoxin like 1 2 2
MIRT545503 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT546724 RNF6 ring finger protein 6 2 2
MIRT546737 RNF141 ring finger protein 141 2 2
MIRT550889 ACTA1 actin, alpha 1, skeletal muscle 2 2
MIRT554180 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT555878 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT558458 DCUN1D1 defective in cullin neddylation 1 domain containing 1 2 2
MIRT560375 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT562672 AKT3 AKT serine/threonine kinase 3 2 2
MIRT563810 TUBA1B tubulin alpha 1b 2 2
MIRT564607 ZNF711 zinc finger protein 711 2 2
MIRT564881 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT566724 MSL2 MSL complex subunit 2 2 2
MIRT566900 CSRP3 cysteine and glycine rich protein 3 2 2
MIRT570002 COL1A2 collagen type I alpha 2 chain 2 2
MIRT612300 ZFP14 ZFP14 zinc finger protein 2 2
MIRT618334 ZNF813 zinc finger protein 813 2 2
MIRT627658 RSBN1 round spermatid basic protein 1 2 2
MIRT630660 PLAG1 PLAG1 zinc finger 2 2
MIRT640802 MYCL1 MYCL proto-oncogene, bHLH transcription factor 1 1
MIRT651370 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT709227 GPSM2 G protein signaling modulator 2 2 2
MIRT712058 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT725006 ZPBP zona pellucida binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-569 Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-569 Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-569 Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (50nM)
hsa-miR-569 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (50nM)
hsa-mir-569 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-mir-569 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-569 Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-569 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-569 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-569 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-569 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-569 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-569 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)

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