pre-miRNA Information
pre-miRNA hsa-mir-16-2   
Genomic Coordinates chr3: 160404745 - 160404825
Description Homo sapiens miR-16-2 stem-loop
Comment This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-16-2-3p
Sequence 53| CCAAUAUUACUGUGCUGCUUUA |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30477465 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs746992239 2 dbSNP
rs775368833 4 dbSNP
rs373202341 10 dbSNP
rs768780684 13 dbSNP
rs1341798864 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RAB1A   
Synonyms RAB1, YPT1
Description RAB1A, member RAS oncogene family
Transcript NM_004161   
Other Transcripts NM_015543   
Expression
Putative miRNA Targets on RAB1A
3'UTR of RAB1A
(miRNA target sites are highlighted)
>RAB1A|NM_004161|3'UTR
   1 AATTTGCCTCCATCCTTTTCTCACAGCAATGAATTTGCAATCTGAACCCAAGTGAAAAAACAAAATTGCCTGAATTGTAC
  81 TGTATGTAGCTGCACTACAACAGATTCTTACCGTCTCCACAAAGGTCAGAGATTGTAAATGGTCAATACTGACTTTTTTT
 161 TTATTCCCTTGACTCAAGACAGCTAACTTCATTTTCAGAACTGTTTTAAACCTTTGTGTGCTGGTTTATAAAATAATGTG
 241 TGTAATCCTTGTTGCTTTCCTGATACCAGACTGTTTCCCGTGGTTGGTTAGAATATATTTTGTTTTGATGTTTATATTGG
 321 CATGTTTAGATGTCAGGTTTAGTCTTCTGAAGATGAAGTTCAGCCATTTTGTATCAAACAGCACAAGCAGTGTCTGTCAC
 401 TTTCCATGCATAAAGTTTAGTGAGATGTTATATGTAAGATCTGATTTGCTAGTTCTTCCTTGTAGAGTTATAAATGGAAA
 481 GATTACACTATCTGATTAATAGTTTCTTCATACTCTGCATATAATTTGTGGCTGCAGAATATTGTAATTTGTTGCACACT
 561 ATGTAACAAAACAACTGAAGATATGTTTAATAAATATTGTACTTATTGGAAGTAATATCAAACTGTATGGTGATAAGTAT
 641 TGTTTTGATTCTTATGGTTAAAGGGAAATAGAGCCTTGCATTATATTCAACACAGCCATTTGTGTGTGCACAATGCAAAC
 721 TAAGGTATTCTAGACCTATCTTAGAGCAGCATCCAGTATTTGCTTTCTAGATAATATGCCCAATAACATGACCTAGAGGG
 801 GCTTCTGTGCTGTGTAGGGATTTAACCAACTTCAGTGGTTCAGGGAGCTCAAACTATATGTAAAACAAGTTTAGAATGTA
 881 TGCTATCTAGCCCGTTATCTCTGATCCTTCTCTAAAACCATTTGAAATAGCTTCATTGATCAACATTTCATAAATGCATC
 961 TGTGGTAGAGGTAGAAAGCAGCACCTTTCCTAATTGGCAAATGATCAGACTAATGTGTGCTAATGTTTTTCTTCCATGCT
1041 TTCAGTCAGATTCAACTATTTTATCCTCCACAGTTGCTTAACTTGGTGTTGGAGGAGGGTTTAAGCATTAAGATAGGAAG
1121 CAGGAAATTTGATTGCTCTAAATTTAGAAATTATATCCCTAAAAATTAAAACATGAATACTGGGTGGTAATGATAATTGA
1201 GGCAAATGTATTTATTTTGGTGACATTTTGCATATATGAAGATTTTCTGAAATAGGACCTTCAAGATCCTAGGGGGTTTT
1281 GTTTGGTTTTTAATTGTGAGGAATAAAAAATCTTCTGCCCACACTGGCATTTTAAGGTGACTGAGGTCAAACGTTGTTTC
1361 CTTAGGTTGAAATAGCAGCCAAAACATTCTTCACGCAGGGGCTTGGGATATGGCTGCTGGCAACACATTTTGTTGTGGGC
1441 TCCTTAATTTAATGATAAAATTTAAGCTAAACACAAGCCAAAAATGAATAGGTTTTTTTAATTTTTATTTTTCACTAAAC
1521 AGGCAATTGAAATACATGGTACAAAAATAAGTGGTAAGATAATTGTAAAATGAAATGGACAGAATATTCAATTTTCCATC
1601 TATGAAAATTTCACAATAAAAATCATAGTTTACTTTGTAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' auuuCGUCG-UGUCAUUAUAACc 5'
              |::|| :||| ||||||| 
Target 5' atttGTGGCTGCAG-AATATTGt 3'
524 - 545 157.00 -10.60
2
miRNA  3' auUUCGUCGUGUCA----UUAUAACc 5'
            || | |:|::||    |:||||| 
Target 5' tcAAACTGTATGGTGATAAGTATTGt 3'
618 - 643 142.00 -7.51
3
miRNA  3' auUUCGUCGUGUCAUUAUAAcc 5'
            || ::| |||| ||||||  
Target 5' tgAAATGG-ACAG-AATATTca 3'
1571 - 1590 138.00 -6.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20074432 11 COSMIC
COSN14003094 12 COSMIC
COSN26547594 16 COSMIC
COSN30168076 131 COSMIC
COSN31518915 153 COSMIC
COSN20921966 262 COSMIC
COSN26669297 279 COSMIC
COSN6190397 680 COSMIC
COSN5508723 690 COSMIC
COSN31528285 763 COSMIC
COSN31589442 845 COSMIC
COSN28202089 1236 COSMIC
COSN31518100 1501 COSMIC
COSN31568100 1550 COSMIC
COSN26577326 1614 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1227489017 7 dbSNP
rs751426005 10 dbSNP
rs1369863651 15 dbSNP
rs763943567 18 dbSNP
rs1289725745 20 dbSNP
rs1405445822 24 dbSNP
rs759806008 25 dbSNP
rs755397579 29 dbSNP
rs1402114237 33 dbSNP
rs750059070 35 dbSNP
rs566920211 40 dbSNP
rs1159522600 43 dbSNP
rs369450925 47 dbSNP
rs1410209424 49 dbSNP
rs1358562591 52 dbSNP
rs947790261 61 dbSNP
rs1272606404 62 dbSNP
rs1465549585 75 dbSNP
rs1013327225 76 dbSNP
rs1479070092 77 dbSNP
rs917630989 82 dbSNP
rs764977210 95 dbSNP
rs1369056179 96 dbSNP
rs886880838 99 dbSNP
rs761186202 100 dbSNP
rs1443384907 107 dbSNP
rs938818436 109 dbSNP
rs1205477937 111 dbSNP
rs924919188 112 dbSNP
rs898710762 113 dbSNP
rs1313872835 117 dbSNP
rs1344645645 126 dbSNP
rs760395230 129 dbSNP
rs150872549 135 dbSNP
rs1329882642 140 dbSNP
rs1315966384 141 dbSNP
rs530260936 146 dbSNP
rs1021575731 148 dbSNP
rs1051076490 150 dbSNP
rs946118671 155 dbSNP
rs975350684 159 dbSNP
rs1256569228 162 dbSNP
rs1185657876 163 dbSNP
rs1277519006 163 dbSNP
rs964100076 166 dbSNP
rs1416552887 167 dbSNP
rs913359801 175 dbSNP
rs1361768091 187 dbSNP
rs1452584251 189 dbSNP
rs1342046796 192 dbSNP
rs1303837131 202 dbSNP
rs1331725714 213 dbSNP
rs1404755859 214 dbSNP
rs1395079391 217 dbSNP
rs987928104 221 dbSNP
rs1474346224 223 dbSNP
rs561046036 226 dbSNP
rs1020093668 228 dbSNP
rs1312746582 229 dbSNP
rs1008089773 235 dbSNP
rs886922704 244 dbSNP
rs957867128 247 dbSNP
rs925166736 248 dbSNP
rs1316604668 252 dbSNP
rs544342002 260 dbSNP
rs1256400360 263 dbSNP
rs1346801183 276 dbSNP
rs1208655759 277 dbSNP
rs760664390 279 dbSNP
rs995821367 290 dbSNP
rs1183782815 295 dbSNP
rs1024625141 297 dbSNP
rs1172162757 308 dbSNP
rs1463625462 310 dbSNP
rs898378884 313 dbSNP
rs1422058560 314 dbSNP
rs1170599244 315 dbSNP
rs1433177387 317 dbSNP
rs75669866 318 dbSNP
rs1473297326 327 dbSNP
rs15048 328 dbSNP
rs1013296486 346 dbSNP
rs1371779458 352 dbSNP
rs538067960 359 dbSNP
rs775634911 361 dbSNP
rs1185950580 373 dbSNP
rs1372648623 375 dbSNP
rs569183939 379 dbSNP
rs1442025436 381 dbSNP
rs1044752935 387 dbSNP
rs947676104 390 dbSNP
rs1303601874 391 dbSNP
rs771978220 400 dbSNP
rs1332610590 404 dbSNP
rs191115996 410 dbSNP
rs1056605960 418 dbSNP
rs1456527200 420 dbSNP
rs1257276206 430 dbSNP
rs1342838152 431 dbSNP
rs1228837049 439 dbSNP
rs1249140679 459 dbSNP
rs1358461354 461 dbSNP
rs898682013 468 dbSNP
rs770810440 481 dbSNP
rs1040332039 486 dbSNP
rs1452172912 487 dbSNP
rs938888808 488 dbSNP
rs1391138114 492 dbSNP
rs1377115715 496 dbSNP
rs1332982827 498 dbSNP
rs1354024320 498 dbSNP
rs924773827 500 dbSNP
rs1295355911 502 dbSNP
rs891397304 502 dbSNP
rs1051046187 505 dbSNP
rs1406454102 531 dbSNP
rs1302457420 532 dbSNP
rs1416638936 535 dbSNP
rs1216274671 542 dbSNP
rs1293275010 544 dbSNP
rs946087291 559 dbSNP
rs1221738594 560 dbSNP
rs1266676224 561 dbSNP
rs1212637935 563 dbSNP
rs1466890055 563 dbSNP
rs913287450 567 dbSNP
rs1472688674 568 dbSNP
rs1451657289 572 dbSNP
rs1185289779 575 dbSNP
rs1381109234 576 dbSNP
rs745699162 580 dbSNP
rs1054487105 585 dbSNP
rs977738315 587 dbSNP
rs947647748 597 dbSNP
rs1392332537 599 dbSNP
rs774675538 606 dbSNP
rs1321404987 609 dbSNP
rs1389111662 611 dbSNP
rs1432720764 613 dbSNP
rs1286887707 615 dbSNP
rs1361248966 618 dbSNP
rs565303305 621 dbSNP
rs1437847353 625 dbSNP
rs1228786888 627 dbSNP
rs925125479 630 dbSNP
rs975404401 633 dbSNP
rs1232315167 643 dbSNP
rs969329904 648 dbSNP
rs981034396 648 dbSNP
rs1214162398 651 dbSNP
rs1241866934 652 dbSNP
rs1483885463 654 dbSNP
rs771209043 655 dbSNP
rs1453225785 663 dbSNP
rs544940077 668 dbSNP
rs758933604 671 dbSNP
rs1354149603 674 dbSNP
rs987287004 680 dbSNP
rs951279994 690 dbSNP
rs1310916322 696 dbSNP
rs1025907313 700 dbSNP
rs1316012628 702 dbSNP
rs995297197 708 dbSNP
rs1237489384 711 dbSNP
rs1344346808 722 dbSNP
rs185120684 728 dbSNP
rs1448699368 736 dbSNP
rs898431234 738 dbSNP
rs1023527355 740 dbSNP
rs1375776157 741 dbSNP
rs991788234 744 dbSNP
rs1274890292 747 dbSNP
rs114374370 750 dbSNP
rs1438046979 755 dbSNP
rs7600616 763 dbSNP
rs995269200 769 dbSNP
rs1221681409 780 dbSNP
rs1284042296 783 dbSNP
rs1322182218 793 dbSNP
rs573919976 795 dbSNP
rs777915934 796 dbSNP
rs896137078 814 dbSNP
rs1213654476 821 dbSNP
rs962806145 822 dbSNP
rs762483968 823 dbSNP
rs142285918 825 dbSNP
rs1254033433 827 dbSNP
rs1417317708 834 dbSNP
rs891372138 835 dbSNP
rs182541222 836 dbSNP
rs571130525 838 dbSNP
rs1406994907 848 dbSNP
rs1160889804 850 dbSNP
rs1175275008 855 dbSNP
rs756216859 856 dbSNP
rs947535161 858 dbSNP
rs1433999450 860 dbSNP
rs1308151258 865 dbSNP
rs1336970835 871 dbSNP
rs557753719 876 dbSNP
rs1407585011 880 dbSNP
rs534357331 884 dbSNP
rs748644728 885 dbSNP
rs1244838347 886 dbSNP
rs912545635 888 dbSNP
rs936079194 891 dbSNP
rs567133381 892 dbSNP
rs374680749 893 dbSNP
rs1347843754 894 dbSNP
rs781703250 897 dbSNP
rs986784154 898 dbSNP
rs1275233776 899 dbSNP
rs1488609328 901 dbSNP
rs755301364 904 dbSNP
rs1436095343 905 dbSNP
rs1181366352 907 dbSNP
rs1247579050 918 dbSNP
rs1287887383 929 dbSNP
rs546937502 933 dbSNP
rs1195317457 946 dbSNP
rs11884205 956 dbSNP
rs973914819 957 dbSNP
rs778379087 958 dbSNP
rs1278924419 964 dbSNP
rs1398018933 968 dbSNP
rs1407785197 969 dbSNP
rs879147058 978 dbSNP
rs1220415583 983 dbSNP
rs1350162158 986 dbSNP
rs1364882142 989 dbSNP
rs917799397 992 dbSNP
rs992096131 994 dbSNP
rs1370654198 1000 dbSNP
rs1229805732 1002 dbSNP
rs1273528205 1006 dbSNP
rs1272364357 1009 dbSNP
rs1338013572 1019 dbSNP
rs1023581585 1022 dbSNP
rs1470024021 1024 dbSNP
rs1012169747 1025 dbSNP
rs1212011443 1037 dbSNP
rs1250928113 1039 dbSNP
rs929600609 1044 dbSNP
rs566816269 1054 dbSNP
rs974170034 1058 dbSNP
rs960438411 1062 dbSNP
rs1474375284 1069 dbSNP
rs1018477735 1073 dbSNP
rs985614645 1085 dbSNP
rs1035106918 1086 dbSNP
rs999164025 1087 dbSNP
rs955543354 1091 dbSNP
rs1029839301 1094 dbSNP
rs1394212609 1097 dbSNP
rs1436363015 1100 dbSNP
rs565463078 1106 dbSNP
rs902281424 1112 dbSNP
rs1227301949 1119 dbSNP
rs567529027 1124 dbSNP
rs550614244 1129 dbSNP
rs1272862881 1140 dbSNP
rs893301824 1143 dbSNP
rs1039965126 1157 dbSNP
rs756944908 1158 dbSNP
rs912772058 1163 dbSNP
rs531050039 1176 dbSNP
rs1416183269 1181 dbSNP
rs753219163 1183 dbSNP
rs1000639279 1194 dbSNP
rs1423132840 1197 dbSNP
rs1175876146 1206 dbSNP
rs1162163356 1209 dbSNP
rs1416789129 1216 dbSNP
rs1478088860 1225 dbSNP
rs929963542 1226 dbSNP
rs565269611 1229 dbSNP
rs1160693333 1232 dbSNP
rs1383202769 1234 dbSNP
rs905913280 1245 dbSNP
rs1044876768 1258 dbSNP
rs1357449163 1269 dbSNP
rs1413077068 1272 dbSNP
rs918695647 1274 dbSNP
rs36072792 1276 dbSNP
rs962577299 1277 dbSNP
rs916410755 1282 dbSNP
rs990619641 1297 dbSNP
rs1487858749 1299 dbSNP
rs960911044 1309 dbSNP
rs1204484881 1311 dbSNP
rs1258223558 1313 dbSNP
rs1034923279 1316 dbSNP
rs929860717 1317 dbSNP
rs1256156447 1322 dbSNP
rs1310138100 1330 dbSNP
rs1183470467 1352 dbSNP
rs1362432633 1353 dbSNP
rs1453407931 1354 dbSNP
rs1174645471 1355 dbSNP
rs1277295083 1365 dbSNP
rs749087321 1367 dbSNP
rs760319470 1379 dbSNP
rs1319187171 1380 dbSNP
rs966391668 1385 dbSNP
rs1022026256 1386 dbSNP
rs1010602261 1387 dbSNP
rs900225642 1389 dbSNP
rs11884049 1394 dbSNP
rs1361709331 1395 dbSNP
rs910936046 1400 dbSNP
rs1007035308 1413 dbSNP
rs1350013137 1416 dbSNP
rs1194448134 1417 dbSNP
rs891385487 1418 dbSNP
rs767595124 1427 dbSNP
rs1279016866 1432 dbSNP
rs985625202 1432 dbSNP
rs191217466 1435 dbSNP
rs1197184259 1437 dbSNP
rs929990585 1438 dbSNP
rs1418131743 1443 dbSNP
rs1194700722 1445 dbSNP
rs1357684708 1453 dbSNP
rs542949916 1462 dbSNP
rs1173500852 1466 dbSNP
rs552982555 1466 dbSNP
rs1463654761 1474 dbSNP
rs1296511292 1481 dbSNP
rs1466227289 1488 dbSNP
rs1425637449 1491 dbSNP
rs555788919 1499 dbSNP
rs1441875239 1500 dbSNP
rs11546467 1507 dbSNP
rs897153220 1512 dbSNP
rs1372848393 1513 dbSNP
rs186268150 1517 dbSNP
rs1232003306 1525 dbSNP
rs1302499087 1530 dbSNP
rs557212318 1533 dbSNP
rs1168452316 1535 dbSNP
rs1038498808 1536 dbSNP
rs1480126832 1543 dbSNP
rs543511407 1548 dbSNP
rs1427643565 1558 dbSNP
rs1255300733 1563 dbSNP
rs181533930 1567 dbSNP
rs1414237399 1569 dbSNP
rs557598369 1577 dbSNP
rs1193399472 1589 dbSNP
rs1430787742 1591 dbSNP
rs1168475053 1598 dbSNP
rs990673548 1605 dbSNP
rs1462184904 1609 dbSNP
rs956282613 1615 dbSNP
rs138999104 1616 dbSNP
rs1396411832 1617 dbSNP
rs1183453879 1620 dbSNP
rs571987447 1623 dbSNP
rs1242203669 1625 dbSNP
rs1198673502 1628 dbSNP
rs1216220076 1639 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5861.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000409892.1 | 3UTR | AAUAUUGUAAUUUGUUGCACACUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.652 9.2e-4 0.792 1.6e-5 20 Click to see details
GSE42095 Differentiated embryonic stem cells -0.53 4.6e-3 -0.520 5.5e-3 23 Click to see details
GSE28544 Breast cancer 0.443 1.5e-2 0.534 3.6e-3 24 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.69 2.0e-2 0.600 4.4e-2 9 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.333 5.2e-2 0.353 4.2e-2 25 Click to see details
GSE19536 Breast cancer -0.127 1.0e-1 -0.123 1.1e-1 100 Click to see details
GSE38226 Liver fibrosis 0.275 1.1e-1 0.341 6.5e-2 21 Click to see details
GSE19783 ER+ ER+ breast cancer -0.269 1.3e-1 -0.388 4.5e-2 20 Click to see details
GSE17498 Multiple myeloma 0.174 1.4e-1 0.028 4.3e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.123 2.8e-1 0.146 2.5e-1 24 Click to see details
GSE19783 ER- ER- breast cancer -0.063 2.9e-1 -0.070 2.7e-1 79 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.069 3.7e-1 0.139 2.5e-1 25 Click to see details
GSE32688 Pancreatic cancer 0.059 3.7e-1 0.056 3.8e-1 32 Click to see details
GSE28260 Renal cortex and medulla 0.078 4.0e-1 0.225 2.3e-1 13 Click to see details
GSE21687 Ependynoma primary tumors 0.024 4.3e-1 0.064 3.1e-1 64 Click to see details
GSE19350 CNS germ cell tumors 0.058 4.3e-1 0.070 4.1e-1 12 Click to see details
GSE21032 Prostate cancer -0.012 4.6e-1 -0.010 4.6e-1 83 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.606 0 0.582 0 31 Click to see details
CHOL -0.757 0.01 -0.683 0.02 9 Click to see details
PAAD -0.981 0.01 -0.800 0.1 4 Click to see details
UCEC -0.496 0.02 -0.418 0.04 19 Click to see details
LUAD 0.46 0.07 0.315 0.16 12 Click to see details
HNSC 0.226 0.08 0.337 0.01 42 Click to see details
ESCA 0.433 0.09 0.391 0.12 11 Click to see details
KIRP 0.241 0.09 0.156 0.2 32 Click to see details
PRAD -0.185 0.1 -0.262 0.04 48 Click to see details
THCA -0.133 0.16 -0.099 0.23 59 Click to see details
KIRC 0.111 0.18 0.171 0.08 68 Click to see details
CESC -0.768 0.22 -0.500 0.33 3 Click to see details
LUSC -0.1 0.28 -0.182 0.14 38 Click to see details
LIHC -0.082 0.29 -0.109 0.23 49 Click to see details
KICH 0.112 0.3 -0.002 0.5 25 Click to see details
BLCA 0.114 0.33 0.323 0.1 18 Click to see details
PCPG 0.292 0.41 0.500 0.33 3 Click to see details
BRCA -0.001 0.5 -0.001 0.5 83 Click to see details
BRCA -0.001 0.5 -0.001 0.5 83 Click to see details
BRCA -0.001 0.5 -0.001 0.5 83 Click to see details
75 hsa-miR-16-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004488 RARB retinoic acid receptor beta 3 1
MIRT038707 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 1 1
MIRT057208 PPIF peptidylprolyl isomerase F 2 4
MIRT058726 RSBN1 round spermatid basic protein 1 2 8
MIRT074502 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 4
MIRT081544 ZNF431 zinc finger protein 431 2 4
MIRT096893 ERBB2IP erbb2 interacting protein 2 2
MIRT105124 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT107898 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT109432 KLHL15 kelch like family member 15 2 6
MIRT166742 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 6
MIRT171257 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 2 2
MIRT192760 B2M beta-2-microglobulin 2 2
MIRT194905 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT215599 SUB1 SUB1 homolog, transcriptional regulator 2 2
MIRT223632 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT241605 AMOTL1 angiomotin like 1 2 4
MIRT291174 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT444286 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT463285 ZFX zinc finger protein, X-linked 2 4
MIRT471759 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT479611 CDC25A cell division cycle 25A 2 2
MIRT481497 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 8
MIRT483117 SH3BP5 SH3 domain binding protein 5 2 2
MIRT502279 GRPEL2 GrpE like 2, mitochondrial 2 8
MIRT507838 CCNT1 cyclin T1 2 2
MIRT508179 MTRNR2L6 MT-RNR2-like 6 2 4
MIRT510576 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 6
MIRT517853 RPS4X ribosomal protein S4, X-linked 2 4
MIRT521690 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT525070 FRK fyn related Src family tyrosine kinase 2 2
MIRT527082 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT529552 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530426 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT533909 TBC1D15 TBC1 domain family member 15 2 2
MIRT536627 IPO7 importin 7 2 2
MIRT537647 ERGIC2 ERGIC and golgi 2 2 4
MIRT538512 CLCN3 chloride voltage-gated channel 3 2 2
MIRT539219 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT539348 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT539954 CCT4 chaperonin containing TCP1 subunit 4 2 2
MIRT541208 HOXA10 homeobox A10 2 2
MIRT543216 TMEM117 transmembrane protein 117 2 2
MIRT543399 DROSHA drosha ribonuclease III 2 2
MIRT546648 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT546852 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT549917 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT552998 USP46 ubiquitin specific peptidase 46 2 2
MIRT555254 PREPL prolyl endopeptidase-like 2 2
MIRT555956 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT557095 HOXA9 homeobox A9 2 2
MIRT561396 TUBB2A tubulin beta 2A class IIa 2 2
MIRT561654 RNF219 ring finger protein 219 2 2
MIRT563101 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT565979 RNF44 ring finger protein 44 2 2
MIRT572396 CCDC14 coiled-coil domain containing 14 2 2
MIRT574400 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT607623 VSNL1 visinin like 1 2 2
MIRT610645 CTGF connective tissue growth factor 2 2
MIRT623379 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT624687 AR androgen receptor 2 2
MIRT632089 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT644216 CBS cystathionine-beta-synthase 2 2
MIRT647841 BID BH3 interacting domain death agonist 2 2
MIRT651649 WASF2 WAS protein family member 2 2 2
MIRT689064 AGMAT agmatinase 2 2
MIRT698150 TNPO1 transportin 1 2 2
MIRT700516 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT704081 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT705970 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT715694 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT717184 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT724607 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT724854 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT725401 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-16-2 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-16-2-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-16-2-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-16-2-3p Bortezomib 387447 NSC681239 approved resistant Low Multiple Myeloma tissue
hsa-miR-16-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-16-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-16-2-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-16-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (HCT8)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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