miRTarBase - #MIRT547038


—
pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol POGZ   
Synonyms MRD37, WHSUS, ZNF280E, ZNF635, ZNF635m
Description pogo transposable element derived with ZNF domain
Transcript NM_015100   
Other Transcripts NM_145796 , NM_207171   
Expression
Putative miRNA Targets on POGZ
3'UTR of POGZ
(miRNA target sites are highlighted)		 
>POGZ|NM_015100|3'UTR
   1 GTGTTGGGGTCATGAGGGGGTGTGGAGTGAGGGTGGGAACATGTGAGGGAGGGTAAAGGGGCTTAGGGAAAAGGGGGCAT
  81 ACCAGGTGGGGTATTTGGTTTCTATTTTTTAATTTTATACCACCACTCCCCCCTGAAGTTGACTTACACTTCCCTGTGGA
 161 TTTGTGGATTAATTAGGAAAACCAATAGTAATCACGTCTGAGCCAAGGAGCTGGCCCATTGGTCATTCACTTCTGCTAAA
 241 AACAGGTTTTTGTGACTTTTTTTTTTTTTAAATTTAAATCACTGTGTTTGGTATTTTTCTGACAAAATTAAGAAAAAGAA
 321 AAAAAATTATTTGTGGGCAAATGTTAAATTTTTTTGTTTCCCCTTTTACCTCAATTGTATCATAGTACTGGGTTTTTTTG
 401 TTTGTTTTATTGTGTGGCCAATGTCTTTGGGCATGATGCTATCTAATCATTGTTAATGTGAGAACATTTCTGAAGATGGG
 481 AAAGACAAATTATGTAGCTCACAAACTGGTTTATTATATATATGGATAAAAAACTTTTTTCATTGTGGTCTTAACACTTT
 561 TATATAAAAATGAAAATGGAAAAAAAGTCCCACTGAACTCTCTCTTCCTTCTCCTTTTCTTTCCTTCCCTCTCCAGAGAT
 641 GTTGGTTTCTACAGCAACCCTAGATATAAAATTGTGGCTTTAAAAATGCATGAAACCACCTTTAATTATCCAGAATGAAT
 721 AGATTTGTCTTTTCCTCACCACCTTCCCTCCAAAACATGACATAAACAATATTTTTTGCACTTGTGATCCTTGGCCCCTT
 801 TCCCCATTCTCAACACCATCCATCCCTCTGGACAAAGGATCATACAGGTGTTATTAGCAAGCAAGAGATACTGAAGCGAT
 881 CAAACAGTTTTAGGGTGGAAGCCATTCCCAGTTTGAGTCTTCATCCTGTAAGCCCCCAGGGGCAGTCCCTGCTTTACTGA
 961 ACTTCATCCTGTTAGATGGAGAGCATGCCTGTTTAAGGGATTACTGGTCCTACAGCCAGGAGCTAATTGTTCAAGAAGTG
1041 TTGAACTTTAAAAAGACAAGACCACTTGTTGAAATCCAGCGTGCTCTGTGGCTTTCCCCTATTTCTCTTAATACTTAGGG
1121 AAGAATCTGACAGGAAGAAGCGCACAGGGGTGTGCACAAAGAAAATGACATGAATCTTTATTTTTCACTGCCAGCTTCAA
1201 GGAAAGAAAATTTTTTCTACAATTTGCATGAGGGATTTTTTTAATTGTATGTACTCATGGTTGTAAACCAAAACGTACTG
1281 TACCGTACAGAGAAAAGGAGCAAAAAACCAAGTCTTCTGTTTATCCTGAGGCTTTCCACAATGTTCCCCTCCTGTGAGCC
1361 AAGGAGGCAAACTGCACAAGCTTGTAAATGGTTCGTCTTTAAAATGTACATAAGTGGAACATTTAATAAAATGAGGGGAA
1441 ATGGATTTATAAACTTGTTTTTTTTCTAGGTGACCCTGTTTAATAGGCTTTCACAGACTGGGGAATGCTCAAGATGTGAT
1521 GGGCCTGGTGGTACAGGTGTGACATTTGTTACCACCCATTTCTCCCACCCCACCCTGCTTTTTTGTTTGTTTGTTTTTTC
1601 ATCCCCCAGCACACTATAATATAGTGAACTGGAAAAGTCCCTTCCAGAAACAGCTTGGCCAGCTTTGTGAACCTTTGACA
1681 TCTGAAAACAACCAAGGATCCATCTGGGCTTCTCTTCCCCAGCTTTTTGCCTGATGCCATTTTATTGACAGACAATGGAC
1761 TTTGAAGTCAGCCTTTGCCTTTGAGAAAGTTCAAGAACTATGGTTGGTCACGTCTATCTACAACCTAATCCTACTCTTTG
1841 GTAGTCTCTGCAGCAGCCACAGCCTTAGCAGAGCTGGGGTTCCTGTCTTCTGCACACGATTGACTTTCTTGATGGGTAAT
1921 TTTTTTTAAGATTATACCAACAGTGGATCAGCTGGGTTTTGGCCAGGAAGTTGTCTTTGTGGACTCTGCCTGCATGGCTT
2001 AGTAGTAGAAGGAAATTTTTTTTTGGTTTTGTTTTTTATAATTCAGTTTAATCAATAAACATGTATTTATTGACTGTTAA
2081 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augCGGUCAGUUA--UGGAACACu 5'
             |||||  |:|   |:||||| 
Target 5' ttgGCCAGGAAGTTGTCTTTGTGg 3'
 1959 - 1982 141.00 -19.00
2 
miRNA  3' augCGGUCAGUUAUGGAACACu 5'
             ||: | | | :|:||||| 
Target 5' acaGCTTGGCCA-GCTTTGTGa 3'
 1650 - 1670 134.00 -14.50
3 
miRNA  3' augcggucaguuaugGAACACu 5'
                         |||||| 
Target 5' acaatattttttgcaCTTGTGa 3'
 766 - 787 120.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1196316 270 ClinVar
COSN25773725 28 COSMIC
COSN30519413 45 COSMIC
COSN30100359 104 COSMIC
COSN28192160 153 COSMIC
COSN30165922 162 COSMIC
COSN31514894 214 COSMIC
COSN28201329 269 COSMIC
COSN31607082 270 COSMIC
COSN31576856 327 COSMIC
COSN31487363 541 COSMIC
COSN20090358 632 COSMIC
COSN22469086 780 COSMIC
COSN21774101 781 COSMIC
COSN22765075 1081 COSMIC
COSN28686882 1173 COSMIC
COSN15586231 1192 COSMIC
COSN22645072 1193 COSMIC
COSN28645422 1203 COSMIC
COSN24096942 1207 COSMIC
COSN28650276 1211 COSMIC
COSN17075910 1395 COSMIC
COSN31568536 1452 COSMIC
COSN30172116 1457 COSMIC
COSN32082753 1632 COSMIC
COSN26554720 1723 COSMIC
COSN31523178 1770 COSMIC
COSN31526480 1792 COSMIC
COSN26564183 1824 COSMIC
COSN6002644 1836 COSMIC
COSN30177102 1911 COSMIC
COSN15661071 2053 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs762862639 3 dbSNP
rs565910039 5 dbSNP
rs1423218622 7 dbSNP
rs1262321744 9 dbSNP
rs746222426 15 dbSNP
rs774043161 16 dbSNP
rs966762792 19 dbSNP
rs1021355092 20 dbSNP
rs1293398872 21 dbSNP
rs1368948128 21 dbSNP
rs770589404 22 dbSNP
rs748855637 23 dbSNP
rs1361004196 28 dbSNP
rs899803652 29 dbSNP
rs6667714 30 dbSNP
rs1243393917 31 dbSNP
rs769125530 33 dbSNP
rs1298355033 34 dbSNP
rs1005601110 40 dbSNP
rs748097042 42 dbSNP
rs773099326 43 dbSNP
rs199586607 45 dbSNP
rs1363913937 46 dbSNP
rs1163068928 51 dbSNP
rs1220953869 58 dbSNP
rs1335076988 63 dbSNP
rs569625425 67 dbSNP
rs1489445540 69 dbSNP
rs549332677 75 dbSNP
rs888625395 77 dbSNP
rs1047256996 78 dbSNP
rs1400664581 78 dbSNP
rs1160841854 82 dbSNP
rs1172048950 83 dbSNP
rs759920419 84 dbSNP
rs536271605 96 dbSNP
rs1350947266 102 dbSNP
rs558068815 104 dbSNP
rs1306552182 105 dbSNP
rs539726466 110 dbSNP
rs1410840151 111 dbSNP
rs1290390516 117 dbSNP
rs996643505 128 dbSNP
rs900999005 132 dbSNP
rs375749581 133 dbSNP
rs896044026 135 dbSNP
rs940491890 143 dbSNP
rs878916804 147 dbSNP
rs1273835312 150 dbSNP
rs1483228043 151 dbSNP
rs1184108162 154 dbSNP
rs761830850 158 dbSNP
rs1215362450 171 dbSNP
rs1472286359 179 dbSNP
rs886802620 185 dbSNP
rs1048028244 195 dbSNP
rs191000036 196 dbSNP
rs1206859900 197 dbSNP
rs1167194201 214 dbSNP
rs926920349 225 dbSNP
rs570941251 226 dbSNP
rs1331337466 234 dbSNP
rs1272301444 241 dbSNP
rs547509977 243 dbSNP
rs890287635 252 dbSNP
rs527876824 255 dbSNP
rs772705385 257 dbSNP
rs947128354 257 dbSNP
rs913107874 258 dbSNP
rs879063879 269 dbSNP
rs1342826589 270 dbSNP
rs1384998654 270 dbSNP
rs542767502 270 dbSNP
rs923196184 270 dbSNP
rs954680615 270 dbSNP
rs974664617 280 dbSNP
rs1378082349 288 dbSNP
rs1441477270 291 dbSNP
rs552009447 293 dbSNP
rs1299548211 299 dbSNP
rs1460115864 312 dbSNP
rs1353417924 318 dbSNP
rs1447075927 320 dbSNP
rs1187420874 322 dbSNP
rs1164795478 324 dbSNP
rs1390065958 326 dbSNP
rs1005674652 327 dbSNP
rs1169994628 327 dbSNP
rs552957484 327 dbSNP
rs964393614 327 dbSNP
rs1335033703 328 dbSNP
rs1425986180 333 dbSNP
rs1383376910 337 dbSNP
rs1408604332 356 dbSNP
rs952753473 356 dbSNP
rs1432941907 363 dbSNP
rs1055464410 364 dbSNP
rs1440131276 371 dbSNP
rs1025845955 374 dbSNP
rs1343954165 376 dbSNP
rs1219603729 381 dbSNP
rs1179179163 382 dbSNP
rs1479748697 384 dbSNP
rs774421041 385 dbSNP
rs1248169268 392 dbSNP
rs1195870649 400 dbSNP
rs1465740972 400 dbSNP
rs1376445841 402 dbSNP
rs1173562808 408 dbSNP
rs543651432 408 dbSNP
rs938214079 413 dbSNP
rs1431679916 418 dbSNP
rs532006681 421 dbSNP
rs895959518 427 dbSNP
rs1389563709 435 dbSNP
rs982407073 439 dbSNP
rs1361643800 440 dbSNP
rs1384005145 441 dbSNP
rs1321449684 451 dbSNP
rs1330478964 452 dbSNP
rs1436889825 453 dbSNP
rs945594282 478 dbSNP
rs1290281879 481 dbSNP
rs1245822905 483 dbSNP
rs1326623792 491 dbSNP
rs1227472384 492 dbSNP
rs913915571 495 dbSNP
rs1352144247 502 dbSNP
rs769148921 509 dbSNP
rs989447393 521 dbSNP
rs1001758376 524 dbSNP
rs1200002872 529 dbSNP
rs905569297 532 dbSNP
rs866848487 533 dbSNP
rs1042703090 534 dbSNP
rs947164086 534 dbSNP
rs766087470 543 dbSNP
rs1389333224 548 dbSNP
rs1389896017 550 dbSNP
rs1405939196 562 dbSNP
rs958111664 564 dbSNP
rs1028450781 570 dbSNP
rs1348322616 580 dbSNP
rs1409003208 587 dbSNP
rs912972084 587 dbSNP
rs1337196358 588 dbSNP
rs1372228966 589 dbSNP
rs1264405249 595 dbSNP
rs1356248377 600 dbSNP
rs760264302 604 dbSNP
rs1052847272 606 dbSNP
rs1482247731 607 dbSNP
rs933168058 607 dbSNP
rs1406283723 609 dbSNP
rs563195406 609 dbSNP
rs1251470414 612 dbSNP
rs1421156019 612 dbSNP
rs1185489324 613 dbSNP
rs1367900675 630 dbSNP
rs923089525 631 dbSNP
rs552525751 632 dbSNP
rs1368609821 634 dbSNP
rs188171000 634 dbSNP
rs1308365156 642 dbSNP
rs1398210530 649 dbSNP
rs1393872566 653 dbSNP
rs964616045 658 dbSNP
rs1340620155 660 dbSNP
rs1365341791 662 dbSNP
rs1156739938 667 dbSNP
rs1019849980 668 dbSNP
rs1004152887 673 dbSNP
rs886999410 681 dbSNP
rs1340612489 690 dbSNP
rs911248477 699 dbSNP
rs1026618043 705 dbSNP
rs1252195034 713 dbSNP
rs995170338 721 dbSNP
rs1199016747 722 dbSNP
rs1250129781 725 dbSNP
rs574015320 726 dbSNP
rs894135489 728 dbSNP
rs1445366622 729 dbSNP
rs1055496205 733 dbSNP
rs1200382339 734 dbSNP
rs371665201 735 dbSNP
rs1003015803 739 dbSNP
rs1388280862 742 dbSNP
rs1026167881 757 dbSNP
rs906718878 761 dbSNP
rs1374511311 766 dbSNP
rs1046971557 769 dbSNP
rs1301951510 775 dbSNP
rs994222918 782 dbSNP
rs1454149970 783 dbSNP
rs1317901807 789 dbSNP
rs1363664735 793 dbSNP
rs1228228286 794 dbSNP
rs945655617 795 dbSNP
rs914117025 803 dbSNP
rs1237418587 804 dbSNP
rs1231498904 817 dbSNP
rs1316663883 818 dbSNP
rs1301598534 826 dbSNP
rs1224914284 828 dbSNP
rs1255671452 836 dbSNP
rs1461911699 839 dbSNP
rs771595149 842 dbSNP
rs936689900 843 dbSNP
rs183280013 845 dbSNP
rs1343106063 846 dbSNP
rs1246204343 847 dbSNP
rs921253954 854 dbSNP
rs975519560 869 dbSNP
rs1035853746 871 dbSNP
rs1002230617 877 dbSNP
rs906107846 878 dbSNP
rs1429588147 881 dbSNP
rs965822658 884 dbSNP
rs578035903 886 dbSNP
rs1011212289 887 dbSNP
rs1387362488 887 dbSNP
rs1435172869 906 dbSNP
rs1290021308 917 dbSNP
rs576129369 922 dbSNP
rs866208316 922 dbSNP
rs1300959345 923 dbSNP
rs1324551504 931 dbSNP
rs982989915 932 dbSNP
rs951335561 935 dbSNP
rs1266467148 938 dbSNP
rs1470333189 941 dbSNP
rs1026889956 944 dbSNP
rs1053283244 950 dbSNP
rs1216556120 962 dbSNP
rs1243810730 966 dbSNP
rs761699453 970 dbSNP
rs1487438921 983 dbSNP
rs995368269 987 dbSNP
rs558291238 988 dbSNP
rs538463675 990 dbSNP
rs901708834 994 dbSNP
rs958387499 999 dbSNP
rs1198861397 1001 dbSNP
rs1410741676 1007 dbSNP
rs1400823028 1009 dbSNP
rs367686859 1010 dbSNP
rs1160602993 1013 dbSNP
rs1347485095 1015 dbSNP
rs774327604 1016 dbSNP
rs1447649660 1018 dbSNP
rs1264526418 1019 dbSNP
rs1203874157 1020 dbSNP
rs1456786667 1022 dbSNP
rs1033951306 1033 dbSNP
rs1293310161 1037 dbSNP
rs575904611 1038 dbSNP
rs1346609781 1039 dbSNP
rs1038864332 1040 dbSNP
rs1485756495 1042 dbSNP
rs1002638537 1044 dbSNP
rs1350065228 1055 dbSNP
rs1224431532 1060 dbSNP
rs1286365964 1070 dbSNP
rs768361102 1070 dbSNP
rs556072573 1074 dbSNP
rs749073596 1076 dbSNP
rs1010188867 1080 dbSNP
rs535860230 1081 dbSNP
rs984682898 1083 dbSNP
rs1250657112 1091 dbSNP
rs1054069908 1096 dbSNP
rs1321047299 1099 dbSNP
rs931302187 1101 dbSNP
rs1410899115 1112 dbSNP
rs936889916 1114 dbSNP
rs1422723162 1118 dbSNP
rs918559919 1121 dbSNP
rs1227574198 1126 dbSNP
rs921285379 1131 dbSNP
rs1426987320 1132 dbSNP
rs534734726 1141 dbSNP
rs1040083654 1142 dbSNP
rs944145633 1144 dbSNP
rs567300938 1158 dbSNP
rs1281487344 1168 dbSNP
rs982876300 1173 dbSNP
rs1036293688 1180 dbSNP
rs951244729 1180 dbSNP
rs1315693223 1184 dbSNP
rs919739817 1184 dbSNP
rs980228970 1186 dbSNP
rs1202790159 1198 dbSNP
rs12566673 1203 dbSNP
rs958586036 1204 dbSNP
rs1206261102 1211 dbSNP
rs12566457 1211 dbSNP
rs1002913022 1212 dbSNP
rs571377366 1216 dbSNP
rs3088297 1217 dbSNP
rs747219419 1222 dbSNP
rs1167108155 1225 dbSNP
rs1020487082 1228 dbSNP
rs1410868731 1239 dbSNP
rs551974555 1242 dbSNP
rs1031329338 1243 dbSNP
rs997715721 1244 dbSNP
rs1384923004 1250 dbSNP
rs1374814543 1252 dbSNP
rs1225996354 1254 dbSNP
rs770238137 1257 dbSNP
rs1339898044 1260 dbSNP
rs1039164280 1270 dbSNP
rs1276111068 1274 dbSNP
rs531968750 1275 dbSNP
rs1001131901 1278 dbSNP
rs900052907 1279 dbSNP
rs1039712154 1280 dbSNP
rs1463159325 1282 dbSNP
rs943201817 1283 dbSNP
rs944079061 1284 dbSNP
rs563162709 1285 dbSNP
rs1169966878 1288 dbSNP
rs549693312 1292 dbSNP
rs1195971254 1300 dbSNP
rs1423352980 1301 dbSNP
rs1469430737 1304 dbSNP
rs1177251996 1308 dbSNP
rs1408472290 1317 dbSNP
rs529271487 1340 dbSNP
rs919772297 1341 dbSNP
rs929197781 1347 dbSNP
rs1326919416 1348 dbSNP
rs1432670582 1349 dbSNP
rs1272805884 1357 dbSNP
rs1322412882 1370 dbSNP
rs746253635 1373 dbSNP
rs1340904273 1376 dbSNP
rs1249044686 1378 dbSNP
rs560453105 1390 dbSNP
rs1383509708 1393 dbSNP
rs189940613 1394 dbSNP
rs1207519802 1397 dbSNP
rs972739317 1410 dbSNP
rs769220619 1411 dbSNP
rs927241204 1417 dbSNP
rs758473126 1420 dbSNP
rs1195799714 1421 dbSNP
rs1245277877 1431 dbSNP
rs1480311547 1433 dbSNP
rs1200489386 1436 dbSNP
rs748651479 1443 dbSNP
rs928750418 1448 dbSNP
rs1158023004 1451 dbSNP
rs1450231774 1455 dbSNP
rs1385603582 1458 dbSNP
rs567211686 1460 dbSNP
rs1381736194 1461 dbSNP
rs1336342465 1462 dbSNP
rs1344707092 1466 dbSNP
rs980134328 1466 dbSNP
rs1410703489 1471 dbSNP
rs1348198858 1472 dbSNP
rs540277903 1477 dbSNP
rs1279575251 1488 dbSNP
rs1398729892 1491 dbSNP
rs1270269972 1495 dbSNP
rs1352038371 1499 dbSNP
rs145848446 1506 dbSNP
rs1290198231 1509 dbSNP
rs988978188 1532 dbSNP
rs150277366 1548 dbSNP
rs1223640555 1556 dbSNP
rs1271358269 1562 dbSNP
rs1461543492 1566 dbSNP
rs1032513164 1568 dbSNP
rs1181189105 1572 dbSNP
rs114922608 1573 dbSNP
rs1443190099 1575 dbSNP
rs899992089 1585 dbSNP
rs1364857815 1588 dbSNP
rs1018969072 1589 dbSNP
rs1425102466 1589 dbSNP
rs750686782 1592 dbSNP
rs1439131939 1593 dbSNP
rs1008469297 1594 dbSNP
rs1247961801 1595 dbSNP
rs1337075372 1597 dbSNP
rs767411277 1597 dbSNP
rs1241955070 1601 dbSNP
rs1313602877 1603 dbSNP
rs1359497937 1607 dbSNP
rs879839064 1609 dbSNP
rs1359296059 1612 dbSNP
rs1293919045 1618 dbSNP
rs1294324195 1620 dbSNP
rs891135426 1620 dbSNP
rs1047036801 1622 dbSNP
rs185917242 1631 dbSNP
rs556180690 1634 dbSNP
rs1358501053 1639 dbSNP
rs930065691 1646 dbSNP
rs755328510 1648 dbSNP
rs1038409754 1660 dbSNP
rs1165247292 1671 dbSNP
rs6694569 1677 dbSNP
rs796365526 1677 dbSNP
rs538128247 1682 dbSNP
rs757470543 1682 dbSNP
rs887641750 1682 dbSNP
rs1393822708 1690 dbSNP
rs1444096875 1693 dbSNP
rs3811409 1694 dbSNP
rs1327069467 1698 dbSNP
rs897730046 1701 dbSNP
rs1409345011 1703 dbSNP
rs756986163 1710 dbSNP
rs1306174636 1723 dbSNP
rs1056758241 1724 dbSNP
rs1252143572 1728 dbSNP
rs41271653 1737 dbSNP
rs1166052309 1738 dbSNP
rs1242543612 1755 dbSNP
rs938716182 1756 dbSNP
rs1185403420 1759 dbSNP
rs1385021835 1760 dbSNP
rs949969024 1770 dbSNP
rs1427746343 1807 dbSNP
rs1159566645 1811 dbSNP
rs912906233 1812 dbSNP
rs928589924 1814 dbSNP
rs1464175980 1817 dbSNP
rs1175091610 1820 dbSNP
rs144038653 1822 dbSNP
rs1361745645 1827 dbSNP
rs569824821 1838 dbSNP
rs1180619143 1843 dbSNP
rs1490375986 1844 dbSNP
rs1382033574 1845 dbSNP
rs1270357719 1848 dbSNP
rs768987668 1850 dbSNP
rs957115570 1854 dbSNP
rs1032794455 1856 dbSNP
rs1262735017 1858 dbSNP
rs1324422631 1863 dbSNP
rs1205608203 1864 dbSNP
rs1258923426 1871 dbSNP
rs1485473335 1873 dbSNP
rs1284868074 1877 dbSNP
rs745876324 1880 dbSNP
rs533573323 1885 dbSNP
rs1263500729 1891 dbSNP
rs974485054 1894 dbSNP
rs571341709 1895 dbSNP
rs964591784 1896 dbSNP
rs112398205 1897 dbSNP
rs1370789685 1898 dbSNP
rs557923830 1903 dbSNP
rs551734971 1908 dbSNP
rs1018417786 1920 dbSNP
rs1008915311 1922 dbSNP
rs1227975278 1927 dbSNP
rs1346234995 1928 dbSNP
rs976700867 1937 dbSNP
rs1289964541 1938 dbSNP
rs1304973993 1942 dbSNP
rs372687358 1949 dbSNP
rs1403168949 1954 dbSNP
rs1387669371 1964 dbSNP
rs1403467812 1965 dbSNP
rs955613272 1971 dbSNP
rs1346344776 1974 dbSNP
rs965748100 1974 dbSNP
rs1026074373 1994 dbSNP
rs1017270631 1998 dbSNP
rs1316270027 2002 dbSNP
rs533234131 2003 dbSNP
rs994164011 2005 dbSNP
rs1319520583 2012 dbSNP
rs61818040 2013 dbSNP
rs1007353508 2015 dbSNP
rs1489811024 2017 dbSNP
rs1221413655 2021 dbSNP
rs1269186951 2025 dbSNP
rs368865352 2025 dbSNP
rs898499494 2025 dbSNP
rs951756031 2025 dbSNP
rs1383191509 2026 dbSNP
rs1157999127 2031 dbSNP
rs1027517486 2035 dbSNP
rs1406696022 2035 dbSNP
rs1160531223 2044 dbSNP
rs1430802348 2050 dbSNP
rs538434319 2060 dbSNP
rs897632184 2061 dbSNP
rs1366439010 2063 dbSNP
rs755885441 2063 dbSNP
rs1479807919 2076 dbSNP
rs1242687031 2078 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 23126.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augcggucaGUUAUGGAACACu 5'
                   |||||::|| || 
Target 5' --acauaaaCAAUAUUUUUUGc 3'
 		1 - 20
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000392723.1 | 3UTR | UGACAUAAACAAUAUUUUUUGCACUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000392723.1 | 3UTR | ACAUAAACAAUAUUUUUUGCACUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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